extracellular matrix


Summary: A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.

Top Publications

  1. pmc The extracellular matrix: not just pretty fibrils
    Richard O Hynes
    Howard Hughes Medical Institute, David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 326:1216-9. 2009
  2. ncbi Matrix elasticity directs stem cell lineage specification
    Adam J Engler
    Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, 19104, USA
    Cell 126:677-89. 2006
  3. pmc Mechanisms of hepatic fibrogenesis
    Scott L Friedman
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Gastroenterology 134:1655-69. 2008
  4. pmc Control of stem cell fate by physical interactions with the extracellular matrix
    Farshid Guilak
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Cell Stem Cell 5:17-26. 2009
  5. pmc Growth factors, matrices, and forces combine and control stem cells
    Dennis E Discher
    Biophysical Engineering and Nanobiopolymers Laboratory, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 324:1673-7. 2009
  6. doi Role of YAP/TAZ in mechanotransduction
    Sirio Dupont
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua School of Medicine, viale Colombo 3, 35131 Padua, Italy
    Nature 474:179-83. 2011
  7. ncbi Formation and function of the myofibroblast during tissue repair
    Boris Hinz
    Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    J Invest Dermatol 127:526-37. 2007
  8. ncbi Role of integrins in cell invasion and migration
    John D Hood
    Scripps Research Institute, Departments of Immunology and Vascular Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Cancer 2:91-100. 2002
  9. ncbi Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
    Cedric Gaggioli
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Nat Cell Biol 9:1392-400. 2007
  10. doi Integrins: masters and slaves of endocytic transport
    Patrick T Caswell
    Beatson Institute for Cancer Research, Cancer Research UK, Glasgow, G61 3BX, Scotland
    Nat Rev Mol Cell Biol 10:843-53. 2009

Detail Information

Publications495 found, 100 shown here

  1. pmc The extracellular matrix: not just pretty fibrils
    Richard O Hynes
    Howard Hughes Medical Institute, David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 326:1216-9. 2009
    The extracellular matrix (ECM) and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases. The ECM has many effects beyond providing structural support...
  2. ncbi Matrix elasticity directs stem cell lineage specification
    Adam J Engler
    Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, 19104, USA
    Cell 126:677-89. 2006
    ..The results have significant implications for understanding physical effects of the in vivo microenvironment and also for therapeutic uses of stem cells...
  3. pmc Mechanisms of hepatic fibrogenesis
    Scott L Friedman
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Gastroenterology 134:1655-69. 2008
    ..Clinical and translational implications of these advances have become clear, and have begun to impact significantly on the management and outlook of patients with chronic liver disease...
  4. pmc Control of stem cell fate by physical interactions with the extracellular matrix
    Farshid Guilak
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Cell Stem Cell 5:17-26. 2009
    ..In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM ..
  5. pmc Growth factors, matrices, and forces combine and control stem cells
    Dennis E Discher
    Biophysical Engineering and Nanobiopolymers Laboratory, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 324:1673-7. 2009
    ..Multifaceted technologies are increasingly required to produce and interrogate cells ex vivo, to build predictive models, and, ultimately, to enhance stem cell integration in vivo for therapeutic benefit...
  6. doi Role of YAP/TAZ in mechanotransduction
    Sirio Dupont
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua School of Medicine, viale Colombo 3, 35131 Padua, Italy
    Nature 474:179-83. 2011
    ..microenvironment not only through soluble signals but also through physical and mechanical cues, such as extracellular matrix (ECM) stiffness or confined adhesiveness...
  7. ncbi Formation and function of the myofibroblast during tissue repair
    Boris Hinz
    Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    J Invest Dermatol 127:526-37. 2007
    ..and more recently discovered markers of the myofibroblast cytoskeleton, membrane surface proteins, and the extracellular matrix. Moreover, intervening with myofibroblast stress perception and transmission offers novel strategies to ..
  8. ncbi Role of integrins in cell invasion and migration
    John D Hood
    Scripps Research Institute, Departments of Immunology and Vascular Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Cancer 2:91-100. 2002
    ..The attachment is mediated by cell-surface receptors known as integrins, which bind to components of the extracellular matrix. Integrins are crucial for cell invasion and migration, not only for physically tethering cells to the ..
  9. ncbi Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
    Cedric Gaggioli
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Nat Cell Biol 9:1392-400. 2007
    ..reveals that the leading cell is always a fibroblast and that carcinoma cells move within tracks in the extracellular matrix behind the fibroblast...
  10. doi Integrins: masters and slaves of endocytic transport
    Patrick T Caswell
    Beatson Institute for Cancer Research, Cancer Research UK, Glasgow, G61 3BX, Scotland
    Nat Rev Mol Cell Biol 10:843-53. 2009
    ..Furthermore, integrins can exert control over the trafficking of other receptors in a way that drives cancer cell invasion and tumour angiogenesis...
  11. pmc Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis
    Muhammad H Zaman
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:10889-94. 2006
    ..Our experimental findings here represent, to our knowledge, discovery of a previously undescribed set of balances of cell and matrix properties that govern the ability of tumor cells to migration in 3D environments...
  12. pmc The C terminus of talin links integrins to cell cycle progression
    Pengbo Wang
    Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Manchester M13 9PT, England, UK
    J Cell Biol 195:499-513. 2011
    Integrins are cell adhesion receptors that sense the extracellular matrix (ECM) environment...
  13. ncbi Myofibroblasts and mechano-regulation of connective tissue remodelling
    James J Tomasek
    Department of Cell Biology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Nat Rev Mol Cell Biol 3:349-63. 2002
  14. pmc Plasticity of cell migration: a multiscale tuning model
    Peter Friedl
    Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, 6500 HB Nijmegen, Netherlands
    J Cell Biol 188:11-9. 2010
    ..Using a multiparameter tuning model, we describe how dimension, density, stiffness, and orientation of the extracellular matrix together with cell determinants-including cell-cell and cell-matrix adhesion, cytoskeletal polarity and ..
  15. ncbi Macrophages: obligate partners for tumor cell migration, invasion, and metastasis
    John Condeelis
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell 124:263-6. 2006
    ..Thus, macrophages are at the center of the invasion microenvironment and are an important drug target for cancer therapy...
  16. ncbi Tumor stroma and regulation of cancer development
    Thea D Tlsty
    Department of Pathology and Comprehensive Cancer Center, University of California, San Francisco, California 94115, USA
    Annu Rev Pathol 1:119-50. 2006
    ..that, like organogenesis during embryonic development and tissue repair in adult mammals, are regulated by interactions between epithelial cells, activated stromal cells, and soluble and insoluble components of the extracellular matrix.
  17. pmc Balancing forces: architectural control of mechanotransduction
    Christopher C DuFort
    Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco UCSF, CA, USA
    Nat Rev Mol Cell Biol 12:308-19. 2011
    ..Furthermore, sustained disruptions in tensional homeostasis can be caused by alterations in the extracellular matrix, allowing it to serve as a mechanically based memory-storage device that can perpetuate a disease or ..
  18. pmc Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism
    D Riveline
    Laboratory of Physical Spectrometry (CNRS, UMR 5588, Joseph Fourier University, French National Center for Scientific Research, BP87, , France
    J Cell Biol 153:1175-86. 2001
    ..Our experiments show that integrin-containing focal complexes behave as individual mechanosensors exhibiting directional assembly in response to local force...
  19. ncbi The matrix corroded: podosomes and invadopodia in extracellular matrix degradation
    Stefan Linder
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Pettenkoferstr 9, 80336 Munchen, Germany
    Trends Cell Biol 17:107-17. 2007
    ..actin-rich adhesions that establish close contact to the substratum but can also degrade components of the extracellular matrix. Accordingly, matrix degradation localized at podosomes or invadopodia is thought to contribute to cellular ..
  20. ncbi The extracellular matrix guides the orientation of the cell division axis
    Manuel Thery
    Biologie du cycle cellulaire et de la motilité, UMR144, CNRS, Institut Curie, 26 rue d Ulm 75248 Paris Cedex 05, France
    Nat Cell Biol 7:947-53. 2005
    ..The cell environment is composed of an extracellular matrix (ECM), which is connected to the intracellular actin cytoskeleton via transmembrane proteins...
  21. ncbi Podosomes: adhesion hot-spots of invasive cells
    Stefan Linder
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Pettenkoferstrasse 9, 80336 Munich, Germany
    Trends Cell Biol 13:376-85. 2003
    ..Here, we summarize and discuss the known structural, regulatory and functional features of podosomes, our aim being to stimulate further research into these unique structures...
  22. ncbi Integrin signalling during tumour progression
    Wenjun Guo
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, Weill Graduate School of Medical Sciences, Sloan Kettering Institute Cornell University, New York, New York, USA
    Nat Rev Mol Cell Biol 5:816-26. 2004
    ..The effect of these integrins might be especially important in cancer cells that have activating mutations, or amplifications, of the genes that encode these RTKs...
  23. ncbi Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
    Tony Yeung
    Institute for Medicine and Engineering, University of Pennsylvania, PA 19104, USA
    Cell Motil Cytoskeleton 60:24-34. 2005
    ..These results support the hypothesis that mechanical factors impact different cell types in fundamentally different ways, and can trigger specific changes similar to those stimulated by soluble ligands...
  24. pmc Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation
    Ana M Pasapera
    Cell Biology and Physiology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 188:877-90. 2010
    ..of both the cytoskeletal adapter protein vinculin and the tyrosine kinase FA kinase (FAK) are myosin II and extracellular matrix (ECM) stiffness dependent...
  25. pmc Three-dimensional culture models of normal and malignant breast epithelial cells
    Genee Y Lee
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nat Methods 4:359-65. 2007
    b>Extracellular matrix is a key regulator of normal homeostasis and tissue phenotype. Important signals are lost when cells are cultured ex vivo on two-dimensional plastic substrata...
  26. pmc Nanoscale architecture of integrin-based cell adhesions
    Pakorn Kanchanawong
    National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 468:580-4. 2010
    Cell adhesions to the extracellular matrix (ECM) are necessary for morphogenesis, immunity and wound healing...
  27. doi Role of the extracellular matrix in regulating stem cell fate
    Fiona M Watt
    King s College London Centre for Stem Cells and Regenerative Medicine, London, UK
    Nat Rev Mol Cell Biol 14:467-73. 2013
    ..One of those signals is from the extracellular matrix (ECM)...
  28. ncbi Extracellular matrix remodelling: the role of matrix metalloproteinases
    Ivan Stamenkovic
    Experimental Pathology Division, Institut Universitaire de Pathologie, Universite de Lausanne, 25 Rue du Bagnon, CH 1011 Lausanne, Switzerland
    J Pathol 200:448-64. 2003
    ..MMPs) are a growing family of metalloendopeptidases that cleave the protein components of the extracellular matrix and thereby play a central role in tissue remodelling...
  29. pmc ECM remodeling in hypertensive heart disease
    Bradford C Berk
    Cardiovascular Research Institute and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    J Clin Invest 117:568-75. 2007
    ..Recent research suggests that therapies targeting the expression, synthesis, or activation of the enzymes responsible for ECM homeostasis might represent novel opportunities to modify the natural progression of HHD...
  30. pmc Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality
    Timothy C Wong
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Circulation 126:1206-16. 2012
    b>Extracellular matrix expansion may be a fundamental feature of adverse myocardial remodeling, it appears to be treatable, and its measurement may improve risk stratification...
  31. ncbi Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
    M P Lutolf
    Integrative Biosciences Institute, Ecole Polytechnique Federale de Lausanne EPFL, Building AA B 039, CH 1015 Lausanne, Switzerland
    Nat Biotechnol 23:47-55. 2005
  32. ncbi Basement membranes: structure, assembly and role in tumour angiogenesis
    Raghu Kalluri
    Center for Matrix Biology, Department of Medicine, Dana 514, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Rev Cancer 3:422-33. 2003
    In recent years, the basement membrane (BM)--a specialized form of extracellular matrix (ECM)--has been recognized as an important regulator of cell behaviour, rather than just a structural feature of tissues...
  33. ncbi Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function
    Vira V Artym
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical School, Washington, District of Columbia 20057 1469, USA
    Cancer Res 66:3034-43. 2006
    Metastatic tumor cells that actively migrate and invade surrounding tissues rely on invadopodia to degrade extracellular matrix (ECM) barriers. Invadopodia are membrane protrusions that localize enzymes required for ECM degradation...
  34. ncbi Differential transmission of actin motion within focal adhesions
    Ke Hu
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 315:111-5. 2007
  35. pmc Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ
    John P Iredale
    Medical Research Council University of Edinburgh Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Invest 117:539-48. 2007
    ..This Review highlights the manner in which studies of models of liver fibrosis have contributed to the paradigm of dynamic wound healing in this solid organ...
  36. doi Breaching the basement membrane: who, when and how?
    R Grant Rowe
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, The Life Sciences Institute, University of Michigan, 210 Washtenaw, Ann Arbor, MI 48109 2216, USA
    Trends Cell Biol 18:560-74. 2008
    The basement membrane (BM), a specialized network of extracellular matrix macromolecules, surrounds epithelial, endothelial, muscle, fat and nerve cells...
  37. ncbi Role of tissue stroma in cancer cell invasion
    Olivier De Wever
    Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    J Pathol 200:429-47. 2003
  38. pmc Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin
    Hideki Yamaguchi
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 168:441-52. 2005
    ..These results indicate that EGF receptor signaling regulates invadopodium formation through the N-WASP-Arp2/3 pathway and cofilin is necessary for the stabilization and maturation of invadopodia...
  39. ncbi Keratinocyte-fibroblast interactions in wound healing
    Sabine Werner
    Institute of Cell Biology, Eidgenossische Technische Hochschule Zurich, Honggerberg, Zurich, Switzerland
    J Invest Dermatol 127:998-1008. 2007
    ..tissue, mesenchymal cells are maximally activated, cells proliferate, and synthesize huge amounts of extracellular matrix. Epithelial cells also proliferate and migrate over the provisional matrix of the underlying granulation ..
  40. pmc Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging
    Cyrus M Ghajar
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 8206, USA
    Histochem Cell Biol 130:1105-18. 2008
    The extracellular matrix (ECM), once thought to solely provide physical support to a tissue, is a key component of a cell's microenvironment responsible for directing cell fate and maintaining tissue specificity...
  41. doi Differential gene regulation under altered gravity conditions in follicular thyroid cancer cells: relationship between the extracellular matrix and the cytoskeleton
    Claudia Ulbrich
    Institute of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Cell Physiol Biochem 28:185-98. 2011
    b>Extracellular matrix proteins, adhesion molecules, and cytoskeletal proteins form a dynamic network interacting with signalling molecules as an adaptive response to altered gravity...
  42. ncbi Reactivation of ocular dominance plasticity in the adult visual cortex
    Tommaso Pizzorusso
    Scuola Normale Superiore, 56100 Pisa, Italy
    Science 298:1248-51. 2002
    ..Chondroitin sulphate proteoglycans (CSPGs) are components of the extracellular matrix (ECM) inhibitory for axonal sprouting...
  43. ncbi Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization
    George E Davis
    Department of Pathology, Texas A and M University System Health Science Center, College Station, USA
    Circ Res 97:1093-107. 2005
    The extracellular matrix (ECM) is critical for all aspects of vascular biology...
  44. pmc Two genetic loci produce distinct carbohydrate-rich structural components of the Pseudomonas aeruginosa biofilm matrix
    Lisa Friedman
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Bacteriol 186:4457-65. 2004
    Pseudomonas aeruginosa forms biofilms, which are cellular aggregates encased in an extracellular matrix. Molecular genetics studies of three common autoaggregative phenotypes, namely wrinkled colonies, pellicles, and solid-surface-..
  45. ncbi Paxillin: adapting to change
    Michael C Brown
    Dept of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Physiol Rev 84:1315-39. 2004
    ..recruits both structural and signaling molecules to focal adhesions, sites of integrin engagement with the extracellular matrix, where it performs a critical role in transducing adhesion and growth factor signals to elicit changes in ..
  46. ncbi Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion
    Katarina Wolf
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Nat Cell Biol 9:893-904. 2007
    Invasive cell migration through tissue barriers requires pericellular remodelling of extracellular matrix (ECM) executed by cell-surface proteases, particularly membrane-type-1 matrix metalloproteinase (MT1-MMP/MMP-14)...
  47. ncbi Cell-matrix adhesion
    Allison L Berrier
    Katrina Visiting Faculty Program, National Center on Minority Health and Health Disparities, National Institutes of Health, Bethesda, Maryland, USA
    J Cell Physiol 213:565-73. 2007
    The complex interactions of cells with extracellular matrix (ECM) play crucial roles in mediating and regulating many processes, including cell adhesion, migration, and signaling during morphogenesis, tissue homeostasis, wound healing, ..
  48. pmc Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix
    Pierre Jean Wipff
    Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    J Cell Biol 179:1311-23. 2007
    ..Using cultured myofibroblasts and conditions that permit tension modulation on the extracellular matrix (ECM), we establish that myofibroblast contraction functions as a mechanism to directly activate TGF-beta1 ..
  49. pmc Dynamin participates in focal extracellular matrix degradation by invasive cells
    Massimiliano Baldassarre
    Department of Cell Biology and Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, S Maria Imbaro Chieti, 66030 Italy
    Mol Biol Cell 14:1074-84. 2003
    The degradation of extracellular matrix (ECM) by matrix metalloproteases is crucial in physiological and pathological cell invasion alike...
  50. pmc The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages
    Liliana Schaefer
    Department of Medicine D, Interdisciplinary Center of Clinical Research, Muenster, University of Muenster, Muenster, Germany
    J Clin Invest 115:2223-33. 2005
    ..These findings are potentially relevant for the development of new strategies in the treatment of sepsis...
  51. doi Cancer invasion and the microenvironment: plasticity and reciprocity
    Peter Friedl
    Department of Cell Biology, Radboud University Nijmegen Medical Centre, 6500 HC Nijmegen, The Netherlands
    Cell 147:992-1009. 2011
    ..The resulting "plasticity" contributes to the generation of diverse cancer invasion routes and programs, enhanced tumor heterogeneity, and ultimately sustained metastatic dissemination...
  52. pmc Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method
    Jianhua Zhang
    Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
    Circ Res 111:1125-36. 2012
    ..However, extracellular matrix is also fundamentally involved in cardiac development from the earliest morphogenetic events, such as ..
  53. ncbi Matrigel: basement membrane matrix with biological activity
    Hynda K Kleinman
    NIH, NIDCR, 30 433, 30 Convent Dr MSC 4370, Bethesda, MD 20892 4370, USA
    Semin Cancer Biol 15:378-86. 2005
    The basement membrane extracellular matrix contacts epithelial, endothelial, fat and smooth muscle cells. Because this extracellular matrix is so thin, it had been hard to study its composition, structure, and function...
  54. pmc Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
    Kevin K Kim
    Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, 94143, USA
    Proc Natl Acad Sci U S A 103:13180-5. 2006
    ..These data reveal alveolar epithelial cells as progenitors for fibroblasts in vivo and implicate the provisional extracellular matrix as a key regulator of epithelial transdifferentiation during fibrogenesis.
  55. pmc Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited
    Farideh Sabeh
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 185:11-9. 2009
  56. pmc An overview of tissue and whole organ decellularization processes
    Peter M Crapo
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biomaterials 32:3233-43. 2011
    Biologic scaffold materials composed of extracellular matrix (ECM) are typically derived by processes that involve decellularization of tissues or organs...
  57. pmc Functions and mechanisms of action of CCN matricellular proteins
    Chih Chiun Chen
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago College of Medicine, Chicago, IL 60607, United States
    Int J Biochem Cell Biol 41:771-83. 2009
    Members of the CCN (CYR61/CTGF/NOV) family have emerged as dynamically expressed, extracellular matrix-associated proteins that play critical roles in cardiovascular and skeletal development, injury repair, fibrotic diseases and cancer...
  58. doi The impact of the extracellular matrix on inflammation
    Lydia Sorokin
    Institute of Physiological Chemistry and Pathobiochemistry, University of Munster, 48149 Munster, Germany
    Nat Rev Immunol 10:712-23. 2010
    ..and intravital analyses of leukocyte movement in tissues has drawn attention to the previously neglected extracellular matrix (ECM) and its role in modulating immune cell behaviour in inflamed tissues...
  59. pmc The extracellular matrix: a dynamic niche in cancer progression
    Pengfei Lu
    Breakthrough Breast Cancer Research Unit, University of Manchester, Manchester M20 4BX, England, UK
    J Cell Biol 196:395-406. 2012
    ..A major component of the niche is the extracellular matrix (ECM), a complex network of macromolecules with distinctive physical, biochemical, and biomechanical ..
  60. ncbi Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix
    O Ibraghimov-Beskrovnaya
    Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City 52242
    Nature 355:696-702. 1992
    ..the 156K DAG is a new laminin-binding glycoprotein which may provide a linkage between the sarcolemma and extracellular matrix. These results support the hypothesis that the dramatic reduction in the 156K DAG in Duchenne muscular ..
  61. pmc beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
    Valerie M Weaver
    Department of Pathology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cancer Cell 2:205-16. 2002
    ..These results indicate that integrin-induced polarity may drive tumor cell resistance to apoptosis-inducing agents via effects on NFkappaB...
  62. pmc Regulation of matrix biology by matrix metalloproteinases
    Joni D Mott
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Curr Opin Cell Biol 16:558-64. 2004
    ..Until recently, it has been thought that MMPs participate in these processes simply by degrading extracellular matrix (ECM) molecules...
  63. pmc A cancer cell metalloprotease triad regulates the basement membrane transmigration program
    Kevin Hotary
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 20:2673-86. 2006
    ..invasive pseudopodia through breaches in the basement membrane (BM), a specialized barrier of cross-linked, extracellular matrix macromolecules that underlies epithelial cells and ensheaths blood vessels...
  64. doi Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia
    Renaud Poincloux
    CNRS, UMR144, Membrane and Cytoskeleton Dynamics, and Institut Curie, Paris, France
    J Cell Sci 122:3015-24. 2009
    When migrating away from a primary tumour, cancer cells interact with and remodel the extracellular matrix (ECM)...
  65. pmc The extracellular matrix: an active or passive player in fibrosis?
    Thomas N Wight
    Hope Heart Matrix Biology Program, Benaroya Research Institute, 1201 Ninth Ave, Seattle, WA 98101, USA
    Am J Physiol Gastrointest Liver Physiol 301:G950-5. 2011
    Fibrosis is characterized by excessive accumulation of collagen and other extracellular matrix (ECM) components, and this process has been likened to aberrant wound healing...
  66. pmc Extracellular matrix, inflammation, and the angiogenic response
    Alicia G Arroyo
    Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Melchor Fernandez Almagro 3, Madrid 28029, Spain
    Cardiovasc Res 86:226-35. 2010
    ..This inflammation-induced angiogenesis and the subsequent remodelling steps are in large part mediated by extracellular matrix (ECM) proteins and proteases...
  67. ncbi Cell migration in tumors
    Hideki Yamaguchi
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Curr Opin Cell Biol 17:559-64. 2005
    ..migration of cancer cells, steered by protrusive activity of the cell membrane and its attachment to the extracellular matrix. Recent advances in intravital imaging and the development of an in vivo invasion assay have provided new ..
  68. pmc Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice
    F N Ziyadeh
    Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA 19104 6144, USA
    Proc Natl Acad Sci U S A 97:8015-20. 2000
    ..We conclude that chronic inhibition of the biologic actions of TGF-beta with a neutralizing monoclonal antibody in db/db mice prevents the glomerulosclerosis and renal insufficiency resulting from type 2 diabetes...
  69. pmc The extracellular matrix in development and morphogenesis: a dynamic view
    Tania Rozario
    Department of Cell Biology and the Morphogenesis and Regenerative Medicine Institute, University of Virginia, PO Box 800732, School of Medicine, Charlottesville, VA 22908, USA
    Dev Biol 341:126-40. 2010
    The extracellular matrix (ECM) is synthesized and secreted by embryonic cells beginning at the earliest stages of development...
  70. pmc How matrix metalloproteinases regulate cell behavior
    M D Sternlicht
    Department of Anatomy, University of California, San Francisco, California 94143 0452, USA
    Annu Rev Cell Dev Biol 17:463-516. 2001
    ..factor-binding proteins, cell surface receptors, cell-cell adhesion molecules, and virtually all structural extracellular matrix proteins. Thus MMPs are able to regulate many biologic processes and are closely regulated themselves...
  71. ncbi The myofibroblast in wound healing and fibrocontractive diseases
    G Gabbiani
    Department of Pathology, CMU University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Pathol 200:500-3. 2003
    ..Myofibroblasts synthesize extracellular matrix components such as collagen types I and III and during normal wound healing disappear by apoptosis when ..
  72. ncbi A matrix metalloproteinase expressed on the surface of invasive tumour cells
    H Sato
    Department of Molecular Virology and Oncology, School of Medicine, Kanazawa University, Ishikawa, Japan
    Nature 370:61-5. 1994
    ..by tumour stroma cells and is believed to be crucial for their invasion and metastasis, acting by degrading extracellular matrix macro-molecules such as type IV collagen...
  73. ncbi A hybrid mathematical model of solid tumour invasion: the importance of cell adhesion
    Alexander R A Anderson
    Division of Mathematics, University of Dundee, Dundee DD1 4HN, UK
    Math Med Biol 22:163-86. 2005
    ..we develop focuses on four key variables implicated in the invasion process: tumour cells, host tissue (extracellular matrix), matrix-degradative enzymes and oxygen...
  74. pmc Extracellular matrix turnover and outflow resistance
    Kate E Keller
    Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239 4197, USA
    Exp Eye Res 88:676-82. 2009
    Normal homeostatic adjustment of elevated intraocular pressure (IOP) involves remodeling the extracellular matrix (ECM) of the trabecular meshwork (TM)...
  75. doi Invadopodia: specialized tumor cell structures for the focal degradation of the extracellular matrix
    Roberto Buccione
    Department of Cell Biology and Oncology, Tumor Cell Invasion Laboratory, Consorzio Mario Negri Sud, S Maria Imbaro, Chieti, 66030, Italy
    Cancer Metastasis Rev 28:137-49. 2009
    Invasive tumor-derived or transformed cells, cultured on a flat extracellular matrix substratum, extend specialized proteolytically active plasma membrane protrusions...
  76. ncbi Structure and function of matrix metalloproteinases and TIMPs
    Hideaki Nagase
    Department of Matrix Biology, Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Cardiovasc Res 69:562-73. 2006
    ..This review introduces the members of the MMP family and discusses their domain structure and function, proenyme activation, the mechanism of inhibition by TIMPs and their significance in physiology and pathology...
  77. pmc Collagen reorganization at the tumor-stromal interface facilitates local invasion
    Paolo P Provenzano
    Department of Pharmacology, University of Wisconsin, Madison, WI, USA
    BMC Med 4:38. 2006
  78. doi Extracellular-matrix tethering regulates stem-cell fate
    Britta Trappmann
    Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Nat Mater 11:642-9. 2012
    ..Lower collagen anchoring density resulted in increased differentiation. We conclude that stem cells exert a mechanical force on collagen fibres and gauge the feedback to make cell-fate decisions...
  79. pmc Genome-wide analysis points to roles for extracellular matrix remodeling, the visual cycle, and neuronal development in myopia
    Amy K Kiefer
    23andMe, Mountain View, California, United States of America
    PLoS Genet 9:e1003299. 2013
    ..PRSS56, which has previously been linked to abnormally small eyes; one is in a gene that forms part of the extracellular matrix (LAMA2); two are in or near genes involved in the regeneration of 11-cis-retinal (RGR and RDH5); two are ..
  80. doi Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship
    Pierre Jean Wipff
    Laboratory of Cell Biophysics, Bâtiment SG AA B143, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Eur J Cell Biol 87:601-15. 2008
    ..is generated by dissociation from a large latent protein complex that sequesters latent TGF-beta1 in the extracellular matrix (ECM)...
  81. pmc Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators
    Karl E Kadler
    Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Faculty of Life Sciences, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Curr Opin Cell Biol 20:495-501. 2008
    Collagens are triple helical proteins that occur in the extracellular matrix (ECM) and at the cell-ECM interface...
  82. pmc Assembly of fibronectin extracellular matrix
    Purva Singh
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    Annu Rev Cell Dev Biol 26:397-419. 2010
    In the process of matrix assembly, multivalent extracellular matrix (ECM) proteins are induced to self-associate and to interact with other ECM proteins to form fibrillar networks...
  83. pmc Molecular regulation of lumen morphogenesis
    Anirban Datta
    Department of Anatomy, University of California San Francisco, CA 94143 2140, USA
    Curr Biol 21:R126-36. 2011
    ..We here discuss progress in understanding common design principles underpinning de novo lumen formation and expansion...
  84. pmc Nonpolarized signaling reveals two distinct modes of 3D cell migration
    Ryan J Petrie
    Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 197:439-55. 2012
    ..Thus, the relative polarization of intracellular signaling identifies two distinct modes of 3D cell migration governed intrinsically by RhoA, ROCK, and myosin II and extrinsically by the elastic behavior of the 3D extracellular matrix.
  85. doi The non-coding 3' UTR of CD44 induces metastasis by regulating extracellular matrix functions
    Zina Jeyapalan Rutnam
    Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada
    J Cell Sci 125:2075-85. 2012
    ..Genes encoding the extracellular matrix normally produce large mRNA transcripts including the 3' UTR...
  86. doi Perineuronal nets protect fear memories from erasure
    Nadine Gogolla
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Science 325:1258-61. 2009
    ..We show here that this protection is conferred by extracellular matrix chondroitin sulfate proteoglycans (CSPGs) in the amygdala...
  87. pmc Matrix rigidity regulates cancer cell growth and cellular phenotype
    Robert W Tilghman
    Department of Microbiology and Cancer Center, School of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 5:e12905. 2010
    The mechanical properties of the extracellular matrix have an important role in cell growth and differentiation...
  88. ncbi Collagens--structure, function, and biosynthesis
    K Gelse
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, D 91054 Erlangen, Germany
    Adv Drug Deliv Rev 55:1531-46. 2003
    The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions...
  89. pmc The myofibroblast: one function, multiple origins
    Boris Hinz
    Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne EPFL, Bâtiment SG AA B143, Station 15, CH 1015 Lausanne, Switzerland
    Am J Pathol 170:1807-16. 2007
    ..in wound healing and pathological organ remodeling is well established; the general mechanisms of extracellular matrix synthesis and of tension production by this cell have been amply clarified...
  90. doi Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
    Harald C Ott
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Med 14:213-21. 2008
    ..We decellularized hearts by coronary perfusion with detergents, preserved the underlying extracellular matrix, and produced an acellular, perfusable vascular architecture, competent acellular valves and intact chamber ..
  91. ncbi Biofilms: the matrix revisited
    Steven S Branda
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Trends Microbiol 13:20-6. 2005
    ..an important commonality among biofilms is that their structural integrity critically depends upon an extracellular matrix produced by their constituent cells...
  92. ncbi Capturing complex 3D tissue physiology in vitro
    Linda G Griffith
    Biological Engineering Division, Mechanical Engineering Department and Biotech Pharma Engineering Center, Massachusetts Institute of Technology, 16 429, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Rev Mol Cell Biol 7:211-24. 2006
    ..We emphasize applications that involve epithelial tissues for which 3D models could explain mechanisms of disease or aid in drug development...
  93. ncbi The stem-cell niche as an entity of action
    David T Scadden
    Massachusetts General Hospital Center for Regenerative Medicine, Harvard Stem Cell Institute, 185 Cambridge Street, CPZN 4265A, Boston, Massachusetts 02114, USA
    Nature 441:1075-9. 2006
    ..The interplay between stem cells and their niche creates the dynamic system necessary for sustaining tissues, and for the ultimate design of stem-cell therapeutics...
  94. pmc Hydrogels as extracellular matrix mimics for 3D cell culture
    Mark W Tibbitt
    Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO, USA
    Biotechnol Bioeng 103:655-63. 2009
    ..synthetic hydrogels that incorporate sophisticated biochemical and mechanical cues as mimics of the native extracellular matrix. Ultimately, advances in synthetic-biologic hydrogel hybrids are needed to provide robust platforms for ..
  95. pmc Tissue-engineered lungs for in vivo implantation
    Thomas H Petersen
    Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA
    Science 329:538-41. 2010
    ..lungs from adult rats using a procedure that removes cellular components but leaves behind a scaffold of extracellular matrix that retains the hierarchical branching structures of airways and vasculature...
  96. pmc Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis
    Nicholas O Deakin
    Department of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Mol Biol Cell 22:327-41. 2011
    ..Hic-5 was essential for adhesion formation in 3D ECMs, and analysis of adhesion dynamics and lifetime identified paxillin as a key regulator of 3D adhesion assembly, stabilization, and disassembly...
  97. doi Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor
    Soo Hyun Kim
    Division of Biomedical Sciences, St George s Medical School, University of London, Cranmer Terrace, London, UK
    J Endocrinol 209:139-51. 2011
  98. pmc Biology of Streptococcus mutans-derived glucosyltransferases: role in extracellular matrix formation of cariogenic biofilms
    W H Bowen
    Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
    Caries Res 45:69-86. 2011
    ..Clearly, conformational changes and reactions of Gtfs on surfaces are complex and modulate the pathogenesis of dental caries in situ, deserving further investigation...
  99. doi Degrading devices: invadosomes in proteolytic cell invasion
    Stefan Linder
    Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Eppendorf, 20246 Hamburg, Germany
    Annu Rev Cell Dev Biol 27:185-211. 2011
    ..Invadosomes recruit and secrete proteinases and are thus able to lyse extracellular matrix components...
  100. pmc Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development
    Sanja Ivkovic
    Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095, USA
    Development 130:2779-91. 2003
    Coordinated production and remodeling of the extracellular matrix is essential during development...
  101. pmc Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone
    Monzur Murshed
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, Houston, TX 77030, USA
    Genes Dev 19:1093-104. 2005
    b>Extracellular matrix (ECM) mineralization is a physiological process in bone and a pathological one in soft tissues. The mechanisms determining the spatial restriction of ECM mineralization to bone physiologically are poorly understood...

Research Grants78

  1. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..metalloproteinase production by IL-12-stimulated human gingival fibroblasts, and AGE-induced inhibition of extracellular matrix production by gingival fibroblasts...
  2. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..the characteristic histopathology in patients with SSc, includes increased production of collagen and other extracellular matrix (ECM) components, and accumulation of alpha smooth muscle actin (ASMA) positive myofibroblasts...
  3. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..myogenic gene expression, membrane fusion, satellite cell activation, muscle membrane structure and extracellular matrix processing...
  4. Inhibition of human neutrophil function by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2012
    ..recent study demonstrate that matrix metalloprotease-9 is upregulated by Ft and that subsequent cleavage of extracellular matrix generates a chemoattractant that drives neutrophil migration into the lung...
  5. Lung Lysyl Oxidase Regulation by Metal Ion Homeostasis
    Wande Li; Fiscal Year: 2013
    ..g., collagen, elastin and histone H1, essential for organization and stabilization of the extracellular matrix (ECM) and the cell nucleus...
  6. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012
    ..of a NRSA awarded to this investigator, and will provide data towards future goals of characterizing the extracellular matrix contribution to cytokine rich niches in development and disease...
  7. Rac GTPase signaling during embryonic salivary gland branching morphogenesis
    Sharon Sequeira; Fiscal Year: 2012
    ..Abbreviations used in proposal: 2D, two-dimensional;3D, three-dimensional;BM, basement membrane;ECM, extracellular matrix;GEF, guanine nucleotide exchange factor;GTPase, guanosine triphosphate hydroxylase;IB, immunoblotting;IF, ..
    JERROLD MICHAEL OLEFSKY; Fiscal Year: 2013
    ..To- wards this end, we have identified novel secretory and extracellular matrix proteins (biglycan and galectin 3) and a new GPCR (GPR105) which are differentially highly expressed in ..
  9. CHIH CHANG KEVIN WEI; Fiscal Year: 2014
    ..events in the cardiac interstitial fluid (ISF) space that interact with cell surface molecules to dictate extracellular matrix (ECM) turnover with subsequent maladaptive left ventricular (LV) remodeling...
  10. Bi-functional Therapeutics for Allergy-BFTA
    Swey Shen Chen; Fiscal Year: 2010
    ..inflammatory responses with regard to airway hyperreactivity (AHR), airway remodeling via changes of extracellular matrix (ECM) and contractile issues, and inflammatory cell infiltrate and cytokines...
  11. Brian F Volkman; Fiscal Year: 2016
    ..Chemokines function through at least three distinct types of interactions: dimerization, extracellular matrix glycosaminoglycan (GAG) binding, and GPCR activation...
  12. Gautam Bhave; Fiscal Year: 2016
    ..We recently discovered that peroxidasin, a protein embedded in extracellular matrix, converts H2O2 to highly reactive hypobromous (HOBr) and hypochlorous (HOCl) acid, collectively denoted as ..
  13. Tumor Microenvironment Interactions in Brain Tumors
    Eric C Holland; Fiscal Year: 2010
    ..to other tissues, the brain microenvironment represents a number of unique features, including a distinct extracellular matrix and several specialized host cells such as astrocytes, neurons, oligodendrocytes and the microglia...
  14. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    ..macrophages and T cells), expansion of vascular smooth muscle cells (vSMCs) and buildup of cholesterol and extracellular matrix within the inner lining of arteries...
  15. Targeting AP-1 proteins in COPD
    SEKHAR M POTHIREDDY; Fiscal Year: 2010
    ..Abnormal lung cell proliferation and apoptosis, as well as extracellular matrix degradation, can alter lung cell homeostasis and architecture, leading to the development and progression ..
  16. Howard B Lieberman; Fiscal Year: 2016
    ..that reflect metastasis, including migration towards fibronectin, invasion, cell adhesion to various extracellular matrix proteins, and metastatic behavior in an in vivo model...
  17. Karen Block; Fiscal Year: 2015
    ..Histologically, diabetic nephropathy is characterized as an excessive accumulation of extracellular matrix proteins (Fibronectin and Collagens)...
  18. AIMALIE LYNNETTE HARDAWAY; Fiscal Year: 2014
    ..determine how adipocyte and macrophage-derived CXCL1 and CXCL2 affect tumor cell proliferation, invasion, extracellular matrix degradation and cytokine profiles in vitro, and how the changes in tumor cell aggressiveness ultimately ..
  19. IGFBP-5 and Hsp70 in Extracellular Matrix Homeostasis and Fibrosis
    Kristen L Veraldi; Fiscal Year: 2013
    ..Furthermore, over-expression of IGFBP-5 in vitro and in vivo results in aberrant extracellular matrix (ECM) production, a hallmark of fibrotic disease...
  20. Hypertension and Collagen: Effect of Ac-SDKP
    Nour Eddine Rhaleb; Fiscal Year: 2010
    ..cardiovascular and renal diseases. Inflammation and components of the extracellular matrix (EM) have a negative impact on the physiology and function of end target organs such as the arteries, heart ..
  21. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2010
    ..HEALTH RELEVANCE: Scleroderma also known as systemic sclerosis (SSc) is a disease caused by a surplus of extracellular matrix protein localized in the skin, or it may become systemic with excess collagen collecting in the kidneys, ..
  22. Cyr61/CCN1-Induced Angiogenesis and Vasculogenesis in the Retina
    Brahim Chaqour; Fiscal Year: 2010
    ..Components of the vascular extracellular matrix (ECM) coordinate the execution of multiple angiogenic and vasculogenic activities...
  23. GARY ANDREW WEISMAN; Fiscal Year: 2016
    ..networks enable the P2Y2R to regulate cellular responses, including migration and proliferation, integrin/extracellular matrix interactions, cytoskeletal rearrangements and the expression of cell adhesion molecules and tight junction ..
  24. Use of umbilical cord as a unique stem cell source for tissue regeneration
    Xiao Dong Chen; Fiscal Year: 2013
    ..Our previous studies demonstrated that cellular extracellular matrix (ECM) made by bone marrow cells enhanced MSC attachment and proliferation, and retained their stem cell ..
  25. Marc B Hershenson; Fiscal Year: 2015
    ..stromal cells express high levels of mRNAs encoding matricellular proteins, a subfamily of non-structural extracellular matrix proteins that regulate cell-matrix interactions and fiber deposition...
  26. Evaluating Novel Multi-kinase Peptide Inhibitors as a Treatment for Rheumatoid Ar
    DAVID MEN HWEI TSAI; Fiscal Year: 2013
    ..RA- FLS) has features of tumor-like transformation including anchorage-independent growth, adhesion to the extracellular matrix of cartilage, resistance to apoptotic signaling, and invasiveness to cartilage and bone...
  27. New Molecular and Cellular Mechanisms of Glaucoma
    Andrei Surguchov; Fiscal Year: 2013
    ..One of the targets of g- synuclein is the matrix metalloproteinase-9 (MMP-9) gene. MMP-9 modulates extracellular matrix (ECM) and the alteration of ECM is a key step in glaucomatous damage in the ON...
  28. Dianne Little; Fiscal Year: 2015
    ..Suture repair is the clinical standard of care but re- tear rates of 34-94% have been reported. Extracellular matrix (ECM) scaffolds are used for augmentation of rotator cuff repair because they contain bioactive molecules ..
  29. Aldosterone, Autophagy, and Arterial Stiffness
    Jane A Leopold; Fiscal Year: 2013
    ..the molecular and cellular consequences of aldosterone-induced autophagy for VSMC phenotype, function, and extracellular matrix synthesis under conditions of pulsatile and non-pulsatile flow;ii) examine the effect of aldosterone-..
  30. YVES CLAUDE GORIN; Fiscal Year: 2014
    ..The role of these pathways in hypertrophy, fibrogenic cytokine expression extracellular matrix accumulation and nuclear factor-kappaB activation will be explored in vitro and in vivo...
  31. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2012
    Genetic Analysis of FAK Activity Binding interactions between extracellular matrix proteins such as fibronectin and integrins play fundamental roles during development by controlling cell adhesion, motility, and survival...
  32. Biophysics of the morphology and motility of Borrelia burgdorferi in diverse envi
    Charles W Wolgemuth; Fiscal Year: 2013
    ..burgdorferi is then inoculated into the skin of its mammalian host where it must translocate through the extracellular matrix in order to access small vessels which provide portals for dissemination through the blood...
  33. Devendra K Agrawal; Fiscal Year: 2016
    ..Since atherosclerotic lesions result from inflammation and extracellular matrix formation that are exaggerated by obesity, there is a poor outcome in obese atherosclerotic patients ..
  34. Maha Abdellatif; Fiscal Year: 2016
    ..g. contractile, extracellular matrix, immune response.....
  35. Edgar A Jaimes; Fiscal Year: 2014
    ..an important role in the pathogenesis of end organ injury in hypertension by promoting oxidative stress, extracellular matrix deposition, cell proliferation and inflammation...
  36. Adhesion of Leptospira interrogans to Human Cell Surface Receptors
    Jenifer L Coburn; Fiscal Year: 2010
    ..Adhesion to host cell surfaces and extracellular matrix (ECM) is critical to the pathogenesis of disease for many pathogens...
  37. Bethany B Moore; Fiscal Year: 2016
    ..disorder of the lung that is characterized by the accumulation of myofibroblasts and the deposition of extracellular matrix leading to respiratory failure...
  38. JONATHAN NOAH THON; Fiscal Year: 2014
    ..goals by familiarizing me with the cytoskeletal mechanics, contribution of environmental factors such as extracellular matrix (ECM) components and shear forces, and the signaling pathways that orchestrate PLT formation and regulate ..
  39. Caveolins in the Pathogenesis of Idiopathic Pulmonary Fibrosis
    Dan N Predescu; Fiscal Year: 2010
    ..patients, and ii) #2 To investigate the functional consequences of cav-2 deficiency on TGF? signaling and extracellular matrix production in lung specimens of IPF patients...
  40. ECM compliance and cell cycle control
    RICHARD ASSOIAN; Fiscal Year: 2012
    The extracellular matrix (ECM) controls a large number of physiological processes including differentiation, apoptosis, and proliferation...
  41. Thrombospondin 4 A1
    JOHN W LAWLER; Fiscal Year: 2010
    ..of the thrombospondins (TSPs), including cartilage oligomeric matrix protein (COMP), in the regulation of extracellular matrix (ECM) structure and cellular behavior during tissue genesis and repair is the long-term goal of the ..
  42. KELLY ANNE BURKE; Fiscal Year: 2014
    ..The 3D tissue is also hypothesized have enhanced cell-extracellular matrix (ECM) interactions from a greater amount of ECM that may be deposited around the cells...
  43. Yan Zhang; Fiscal Year: 2016
    ..TGF-[unreadable] family including BMPs and their roles in cell differentiation, tissue morphogenesis, and extracellular matrix production...
  44. Anna Tate Riegel; Fiscal Year: 2015
    ..poor healing of full-thickness skin wounds, defective neo-angiogenesis of wounds, macrophage invasion and extracellular matrix remodeling that was also observed in subcutaneous Matrigel plug colonization assays...
    ..The effectiveness of small molecules, developmental transcription factors, exogenous growth factors, and extracellular matrix materials to induce the renal progenitor cell fate will be evaluated...
  46. Identification of Mechanoresponsive Promoter Elements in Chondrogenesis
    Dominik R Haudenschild; Fiscal Year: 2013
    ..Target genes of mechanotransduction pathways in cartilage include extracellular matrix genes such as Aggrecan and type II collagen and Cartilage Oligomeric Matrix Protein (COMP)...
  47. Lina Lu; Fiscal Year: 2014
    ..cells in the body and are known to be actively involved in liver repair and regeneration by synthesizing extracellular matrix protein and secretion of cytokines and growth factors...
  48. Experimental engineering of ovarian grafting to promote angiogenesis for fertilit
    GLENN LEWIS SCHATTMAN; Fiscal Year: 2010
    ..and cellular quantification of vascular growth, angiogenic factors, follicular survival and factors in the extracellular matrix. In Aim 2, we will test two experimental strategies for improving vascular perfusion and follicle survival ..
  49. The Role of Leptin in Liver Fibrogenesis
    Frank A Anania; Fiscal Year: 2012
    ..reduced tissue inhibitor of metalloproteinase I [TIMP-I] expression that would favor dissolution of dense extracellular matrix, the basis for the pathogenesis of cirrhosis...
  50. Warren G Hill; Fiscal Year: 2014
    DESCRIPTION: Integrins are a broad family of cell surface adhesion and signaling molecules which link the extracellular matrix (ECM) to the cytoskeleton of the cell...
  51. Mechanical and Osmotic Signaling in Chondrocytes
    Farshid Guilak; Fiscal Year: 2013
    ..Biomechanical factors play an important role in the normal homeostatic maintenance of the cartilage extracellular matrix by chondrocytes, and under abnormal conditions, mechanical stress may be a significant factor in the ..
  52. Shared Mechanisms of Valvular and Vascular Calcification
    JOEL DAVID MORRISETT; Fiscal Year: 2012
    ..for therapeutic development, is the tissue retention of lipids by glycosaminoglycans, carbohydrate-based extracellular matrix molecules...
  53. Elucidating the JNK2-mediated redox regulation of cartilage matrix remdeling
    ..been observed in the cartilage of OA patients and may play a role in the stimulation of articular cartilage extracellular matrix (ECM) degradation...
    Gary W Conrad; Fiscal Year: 2012
    ..long-range goal of the proposed research is to understand the biological physical chemistry of the corneal extracellular matrix (ECM) during embryonic development and be able to repair that ECM in adults...
  55. Role of DDR2 in OA-like Pathogenesis in Osteochondrodysplasias
    Yefu Li; Fiscal Year: 2010
    ..changes in articular cartilage that are associated with osteochondrodysplasias caused by mutations in extracellular matrix proteins...
  56. John H Zhang; Fiscal Year: 2016
    ..Thrombin initiates inflammatory responses, gliosis and overproduction of extracellular matrix (ECM) proteins, which obstruct the cerebroventricular system and impair CSF drainage...
  57. Ofer Levy; Fiscal Year: 2016
    ..neonatal tissue construct (NTC) and a corresponding adult tissue construct (ATC), comprised of extracellular matrix, autologous plasma, and an overlying endothelium upon which cryopreserved cord blood- or peripheral blood-..
  58. RUBIE ANN RAKIAN; Fiscal Year: 2016
    ..Their local microenvironment composed of growth factors and extracellular matrix (ECM) is known to play a critical role in controlling the proliferation and differentiation fate of stem ..
  59. Role of Biophysical Cues in the Pathogenesis of Glaucoma
    Paul Russell; Fiscal Year: 2013
    ..determine how these biophysical properties modulate HTM mediated extracellular matrix production and remodeling...
  60. Christopher E Turner; Fiscal Year: 2016
    ..It is a highly dynamic process requiring exquisite spatial and temporal control of cell adhesion to the extracellular matrix (ECM) in coordination with remodeling of the actin cytoskeleton...
  61. Role of Meprin A in Acute Kidney Injury
    GUR PRASAD KAUSHAL; Fiscal Year: 2013
    ..that meprin A is the major matrix-degrading protease in the rat kidney cortex capable of degrading the extracellular matrix (ECM) proteins including collagen IV, fibronectin, laminin, and nidogen in vitro...
  62. Eukaryotic-type STK/STP-mediated modulation of enterococcal pathogenesis
    Vijay Pancholi; Fiscal Year: 2010
    ..those described for GAS and play an important role in the regulation of growth, metabolism, expression of extracellular matrix-binding surface proteins, and toxins, which are important in the development of enterococcal biofilms and ..
  63. Jeffrey B Kaplan; Fiscal Year: 2014
    ..The inherent protective nature of the biofilm matrix makes wound infections difficult to treat. The extracellular matrix of most biofilms contains polymers such as polysaccharides and DNA...
    L Windsor; Fiscal Year: 2001
    ..This erosion of the joint is likely due to an imbalance of extracellular matrix synthesis and metabolism induced, in part, by members of the matrix metalloproteinase (MMP) family...
  65. Chondroitin Sulfate Proteoglycan and Myelination in Intraventricular Hemorrhage
    Praveen Ballabh; Fiscal Year: 2010
    ..Myelination is a dynamic process that needs an appropriate microenvironment containing growth factors, extracellular matrix molecules and myelinating OL...
  66. Enabling Strategies for Growing Collagenous Tissues
    LAURA E contact NIKLASON; Fiscal Year: 2010
    Connective soft tissues, which include skin, fascia, ligament, tendon, blood vessel, etc, rely upon extracellular matrix to provide the bulk of their mechanical properties...
    TAUBE ROTHMAN; Fiscal Year: 2000
    ..reach the gut their differentiation is influenced by signals from the microenvironment, specifically, the extracellular matrix (ECM). Studies have shown that crest-derived cells express a receptor (LBPI 10) when they enter the bowel...
    VICTOR TERRANOVA; Fiscal Year: 1993
    ..b>Extracellular matrix proteins and various polypeptide growth factors have been shown to stimulate both chemotaxis and ..
  69. Studies of Collagen Gene Regulation in Two Murine Models
    Stephen Clark; Fiscal Year: 2005
    ..Both mutations display excessive accumulation of collagen and other extracellular matrix components in the skin, a hallmark feature of the human disease...
    Renny Franceschi; Fiscal Year: 2007
    ..by applicant): The transition from preosteoblasts to osteoblasts involves the secretion of a complex extracellular matrix containing bone morphogenetic proteins, growth factors and structural components that interact with cells ..
  71. Role of extracellular matrix proteins in Candida biofilm formation
    PRANAB KUMAR MUKHERJEE; Fiscal Year: 2010
    Candida albicans (CA) is the most commonly isolated fungus associated with biofilms [extracellular matrix (ECM)-encased microbial communities formed on indwelling medical devices which are resistant against commonly used antifungals...
    Vladimir Tsuprun; Fiscal Year: 2003
    DESCRIPTION (from applicant's abstract): The extracellular matrix, one of the basic constituents of the cochlea, encompasses all of the connective tissue structures of the cochlea (tectorial membrane, spiral limbus, basilar membrane, ..
    George Stricklin; Fiscal Year: 1993
    ..of dermal connective tissue is a feature of growth and development and conversely, destruction of this extracellular matrix is characteristic of neoplastic and inflammatory disorders...
  74. Poly (amino acid) as an Integrin Targeted Drug Carrier
    Xiaoling Li; Fiscal Year: 2005
    Integrins are found to play an important role in the adhesion of cancer cells to the extracellular matrix during cancer metastasis...