tissues

Summary

Summary: Collections of differentiated CELLS, such as EPITHELIUM; CONNECTIVE TISSUE; MUSCLES; and NERVE TISSUE. Tissues are cooperatively arranged to form organs with specialized functions such as RESPIRATION; DIGESTION; REPRODUCTION; MOVEMENT; and others.

Top Publications

  1. Gimpl G, Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol Rev. 2001;81:629-83 pubmed
    ..However, OT is also synthesized in peripheral tissues, e.g., uterus, placenta, amnion, corpus luteum, testis, and heart...
  2. Tutar Y. miRNA and cancer; computational and experimental approaches. Curr Pharm Biotechnol. 2014;15:429 pubmed
    ..Wang and his presented work predicts cancer-related miRNAs by using expression profiles in tumor tissues. The work relies on R-squared method to investigate miRNA-mRNA regulatory relationship between miRNAs and mRNAs ..
  3. Roy S, Esmaeilniakooshkghazi A, Patnaik S, Wang Y, George S, Ahrorov A, et al. Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation. Gastroenterology. 2018;154:1405-1420.e2 pubmed publisher
    ..Distal ileum tissues were collected from mice; IECs and enteroids were cultured and analyzed by histology, immunoblots, phalloidin ..
  4. Pacak K. Phaeochromocytoma: a catecholamine and oxidative stress disorder. Endocr Regul. 2011;45:65-90 pubmed
    ..The concentrations of catecholamines in pheochromocytoma tissues are enormous, potentially creating a volcano that can erupt at any time...
  5. Müderris T, Ürkmez F, Kucuker S, Sağlam M, Yilmaz G, Guner R, et al. [Bacteremia caused by ciprofloxacin-resistant Salmonella serotype Kentucky: a case report and the review of literature]. Mikrobiyol Bul. 2016;50:598-605 pubmed
    ..On the 15th day of SCF treatment, LVAD was taken out, and tissue cultures taken from the fibrillar tissues between pericardial layers during surgery, also yielded S. Kentucky growth...
  6. Bawahab M, Assiri A, Maksoud W, Patel A, Kadoumi O, Zaman G, et al. Effects of Weight Reduction After Sleeve Gastrectomy on Metabolic Variables in Saudi Obese Subjects in Aseer Province of Kingdom of Saudi Arabia. Obes Surg. 2017;27:2005-2014 pubmed publisher
    ..The staging concept of sleeve gastrectomy is a safe and effective approach with remarkable efficacy in sustaining weight loss and bringing back normal metabolism of variables in tissues over a 1-year follow-up period.
  7. Sil R, Ray D, Chakraborti A. Glycyrrhizin ameliorates metabolic syndrome-induced liver damage in experimental rat model. Mol Cell Biochem. 2015;409:177-89 pubmed publisher
    ..After 2 weeks of treatment, rats were sacrificed to collect blood samples and liver tissues. Compared to normal, elevated activities of serum alanine transaminase, alkaline phosphatase and aspartate ..
  8. Song X, Zhu S, Xie Y, Liu J, Sun L, Zeng D, et al. JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice. Gastroenterology. 2018;154:1480-1493 pubmed publisher
    ..We compared gene and protein expression levels between human pancreatic cancer tissues and patient survival times using online R2 genomic or immunohistochemistry analyses...
  9. Hu X, Deng J, Yu T, Chen S, Ge Y, Zhou Z, et al. ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides. Gastroenterology. 2019;156:1098-1111 pubmed publisher
    ..Human and mouse ileal and colon tissues were analyzed by quantitative real-time polymerase chain reaction, immunoblots, and immunohistochemistry...

More Information

Publications97

  1. Gao P, Yang B, Yu H, Meng R, Si J. Carvedilol alleviates the biliary cirrhosis through inhibiting the endoplasmic reticulum stress. Eur Rev Med Pharmacol Sci. 2017;21:5813-5820 pubmed publisher
    ..After modeling, the survival rate of mice in each group was detected, and the blood and liver tissues were taken for detection...
  2. Bleecker M. Carbon monoxide intoxication. Handb Clin Neurol. 2015;131:191-203 pubmed publisher
    ..200 times greater than oxygen that leads to decreased oxygen-carrying capacity and decreased release of oxygen to tissues leading to tissue hypoxia...
  3. Cutolo M. Sex hormone adjuvant therapy in rheumatoid arthritis. Rheum Dis Clin North Am. 2000;26:881-95 pubmed
    ..immune-suppressive activities exerted by CSA, at least in RA and at the level of sensitive target cells and tissues (i.e., synovial macrophages)...
  4. Li S, He Y, Zhao H, Wang Y, Liu J, Shao Y, et al. Assessment of 28 trace elements and 17 amino acid levels in muscular tissues of broiler chicken (Gallus gallus) suffering from arsenic trioxide. Ecotoxicol Environ Saf. 2017;144:430-437 pubmed publisher
    The contents of 28 trace elements, 17 amino acid were evaluated in muscular tissues (wings, crureus and pectoralis) of chickens in response to arsenic trioxide (As2O3)...
  5. Aragón Herrera A, Feijóo Bandín S, Abella V, Alvarez L, Roselló Lletí E, Portolés M, et al. Serelaxin (recombinant human relaxin-2) treatment affects the endogenous synthesis of long chain poly-unsaturated fatty acids and induces substantial alterations of lipidome and metabolome profiles in rat cardiac tissue. Pharmacol Res. 2019;144:51-65 pubmed publisher
    ..Atrial tissues from rats treated with relaxin-2 showed a significant increase in the mRNA levels of Srebf1, a transcription ..
  6. Zhao Z, Barcus M, Kim J, Lum K, Mills C, Lei X. High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs. J Nutr. 2016;146:1625-33 pubmed publisher
    ..expression profiles of lipid and protein metabolism and selenoproteins in plasma, liver, muscle, and adipose tissues were analyzed. In Expt...
  7. Dutkiewicz J, Mackiewicz B, Lemieszek M, Golec M, Milanowski J. Pantoea agglomerans: a mysterious bacterium of evil and good. Part IV. Beneficial effects. Ann Agric Environ Med. 2016;23:206-22 pubmed publisher
    ..P. agglomerans strains associated with both rhizosphere and plant tissues (as endophytes) efficiently promote the growth of many plants, including rice and wheat, which are the staple ..
  8. Simon Y, Kessler S, Gemperlein K, Bohle R, Müller R, Haybaeck J, et al. Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis. World J Gastroenterol. 2014;20:17839-50 pubmed publisher
    ..Additionally, nuclear localization of the nuclear factor kappa B (NF-κB) subunit p65 was examined in frozen tissues. Liver-specific overexpression of the insulin-like growth factor 2 mRNA binding protein 2-2 (IGF2BP2-2/IMP2-2/p62)..
  9. Navarro Valverde C, Quesada Gómez J. [Vitamin D, determinant of bone and extrabone health. Importance of vitamin D supplementation in milk and dairy products]. Nutr Hosp. 2015;31 Suppl 2:18-25 pubmed publisher
    ..stimulation, (1,25)OH)2D3 controls calcium homeostasis and bone health and, what is more, many other cells and tissues including skin, muscle, cardiovascular and immune systems as well as glucose homeostasis...
  10. Babizhayev M. Biochemical, Biomedical and Metabolic Aspects of Imidazole-Containing Dipeptides with the Inherent Complexity to Neurodegenerative Diseases and Various States of Mental Well-Being: A Challenging Correction and Neurotherapeutic Pharmaceutical Biotechn. Curr Pharm Biotechnol. 2014;15:738-78 pubmed
    ..N-acetylcarnosine, carcinine) is revealed presently in a surprisingly large amounts in long-lived human tissues to correct conformational abnormalities leading to distinct neurodegeneration and age-related disease states, ..
  11. Li J, Shi J, Li P, Guo X, Wang T, Liu A. Genipin attenuates hyperoxia-induced lung injury and pulmonary hypertension via targeting glycogen synthase kinase-3 β in neonatal rats. Nutrition. 2019;57:237-244 pubmed publisher
    ..The aim of this study was to show that genipin decreased the expression of GSK-3 β in lung tissues of hyperoxia-exposed rat pups...
  12. Lugea A, Gerloff A, Su H, Xu Z, Go A, Hu C, et al. The Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells. Gastroenterology. 2017;153:1674-1686 pubmed publisher
    ..Pancreatic tissues were collected and analyzed by histology and immunostaining techniques...
  13. Dutkiewicz J, Zając V, Sroka J, Wasiński B, Cisak E, Sawczyn A, et al. Streptococcus suis: a re-emerging pathogen associated with occupational exposure to pigs or pork products. Part II - Pathogenesis. Ann Agric Environ Med. 2018;25:186-203 pubmed publisher
    ..Both 'complementary' clones assist each other in the successful colonization of host's tissues and persistence therein. <i>S...
  14. Tao G, Pan L, Jing R, Lin F, Dai H, Ge W. [Study on Rac1/MAPK/ERK pathway mediated mechanism and role in rats with ventilator induced lung injury]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:249-254 pubmed publisher
    ..After 4-hour ventilation, heart blood, bronchoalveolar lavage fluid (BALF) and lung tissues were harvested...
  15. Bai R, Yin X, Feng X, Cao Y, Wu Y, Zhu Z, et al. Corydalis hendersonii Hemsl. protects against myocardial injury by attenuating inflammation and fibrosis via NF-?B and JAK2-STAT3 signaling pathways. J Ethnopharmacol. 2017;207:174-183 pubmed publisher
    ..tissue homogenate, protein expressions of signal-transduction proteins, p65, I?B?, JAK2, and STAT3 in heart tissues were measured by ELISA and Western blot analyses...
  16. Yun S, Han Y, Lee J, Kim S, Lee S. Enhanced Susceptibility to 5-Fluorouracil in Human Colon Cancer Cells by Silencing of GRP78. Anticancer Res. 2017;37:2975-2984 pubmed
    ..In addition, in tumors, GRP78 expression is much higher than in normal tissues. Furthermore, high levels of GRP78 expression have been shown to increase the risk of malignancy and metastasis ..
  17. Cai H, Su S, Li Y, Zeng H, Zhu Z, Guo J, et al. Protective effects of Salvia miltiorrhiza on adenine-induced chronic renal failure by regulating the metabolic profiling and modulating the NADPH oxidase/ROS/ERK and TGF-?/Smad signaling pathways. J Ethnopharmacol. 2018;212:153-165 pubmed publisher
    ..and tubular atrophy, focal calcium deposits, interstitial fibrosis, interstitial inflammation, and renal tissues. By metabolomics analysis, fifty-nine metabolites (thirteen in plasma, twenty-seven in urine and nineteen in ..
  18. Viswanathan G, Dan V, Radhakrishnan N, Nair A, Rajendran Nair A, Baby S. Protection of mouse brain from paracetamol-induced stress by Centella asiatica methanol extract. J Ethnopharmacol. 2019;: pubmed publisher
    ..Cellular toxicity was investigated by apoptosis/necrosis in primary astrocytes isolated from brain tissues of mouse (which was challenged by CAM/Paracetamol) by flow cytometry and fluorescent microscopy...
  19. Liu T, Yang H, Fan W, Tu J, Li T, Wang J, et al. Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. Gastroenterology. 2018;155:557-571.e14 pubmed publisher
    ..We studied mechanisms of MAFG up-regulation in cholestatic tissues and the pathways by which S-adenosylmethionine (SAMe) and ursodeoxycholic acid (UDCA) prevent the increase in ..
  20. Calderone V, Gallego J, Fernández Miranda G, Garcia Pras E, Maillo C, Berzigotti A, et al. Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease. Gastroenterology. 2016;150:982-97.e30 pubmed publisher
    ..We obtained transjugular liver biopsies from patients with hepatitis C virus-associated cirrhosis or liver tissues removed during transplantation; healthy human liver tissue was obtained from a commercial source (control)...
  21. Shah N, Khan M, Nigussie D. Phytochemical investigation and nephroprotective potential of Sida cordata in rat. BMC Complement Altern Med. 2017;17:388 pubmed publisher
    ..01) of thiobarbituric acid reactive substances and histopathological injuries were noticed in the renal tissues of rats after the treatment with CCl4...
  22. Yilmaz H, Tekelioglu B, Gurel A, Bamac O, Ozturk G, Cizmecigil U, et al. Frequency, clinicopathological features and phylogenetic analysis of feline morbillivirus in cats in Istanbul, Turkey. J Feline Med Surg. 2017;19:1206-1214 pubmed publisher
    ..Results FmoPV RNA was detected in six cats (5.4%), including three sick (in the urine) and three dead cats (tissues). A significantly greater proportion of FmoPV RNA-positive cats had street access compared with non-infected cats...
  23. Traish A. Negative Impact of Testosterone Deficiency and 5?-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men. Adv Exp Med Biol. 2017;1043:473-526 pubmed publisher
    ..pathways of human physiology and plays a critical role in the growth and/or maintenance of functions in a host of tissues and organs...
  24. Khanra R, Dewanjee S, K Dua T, Sahu R, Gangopadhyay M, De Feo V, et al. Abroma augusta L. (Malvaceae) leaf extract attenuates diabetes induced nephropathy and cardiomyopathy via inhibition of oxidative stress and inflammatory response. J Transl Med. 2015;13:6 pubmed publisher
    ..T2DM altered the redox status, decreased the intracellular NAD and ATP concentrations in renal and myocardial tissues of experimental rats...
  25. Ma Y, Zhang Y, Liang X, Lou F, Oglesbee M, Krakowka S, et al. Origin, evolution, and virulence of porcine deltacoronaviruses in the United States. MBio. 2015;6:e00064 pubmed publisher
    ..High levels of viral RNA (8 to 11 log RNA copies/g) were detected in intestinal tissues/luminal contents and feces of infected piglets, whereas moderate RNA levels (2 to 5 log RNA copies/g) were ..
  26. Hua F, Shang S, Yang Y, Zhang H, Xu T, Yu J, et al. TRIB3 Interacts With β-Catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis. Gastroenterology. 2019;156:708-721.e15 pubmed publisher
    ..Intestinal tissues were collected and analyzed by histology, gene expression profiling, immunohistochemistry, and immunofluorescence...
  27. Nie Y, Yang D, Trivett A, Han Z, Xin H, Chen X, et al. Development of a Curative Therapeutic Vaccine (TheraVac) for the Treatment of Large Established Tumors. Sci Rep. 2017;7:14186 pubmed publisher
    ..caused homing of tumor-infiltrating DC to draining lymph nodes and increased infiltration of T cells into tumor tissues. Cytoxan in this regimen could be replaced by anti-CTLA4) or anti-PD-L1...
  28. Hui F, Nguyen C, He Z, Vingrys A, Gurrell R, Fish R, et al. Retinal and Cortical Blood Flow Dynamics Following Systemic Blood-Neural Barrier Disruption. Front Neurosci. 2017;11:568 pubmed publisher
    ..Our results show that systemic disruption of blood-neural barriers causes vascular leakage in both tissues but earlier in the retina suggesting that pharmacological blood-neural barrier disruption may be detected earlier ..
  29. Steven Howe M, Richards D. Surgical regenerative treatment of peri-implantitis. Evid Based Dent. 2017;18:79-81 pubmed publisher
    ..treatment is a predictable option in managing peri-implantitis and improving clinical parameters of peri-implant tissues. There is no fundamental advantage of membrane use for bone graft coverage or submergence of the healing site on ..
  30. Ozyurtkan M, Kaba E, Toker A. Technological innovation in video-assisted thoracic surgery. J Vis Surg. 2017;3:20 pubmed publisher
    ..Three-dimensional VATS systems facilitated faster and more accurate grasping, suturing, and dissection of the tissues by restoring natural 3D vision and the perception of depth...
  31. Rai V, Agrawal D. Role of Vitamin D in Cardiovascular Diseases. Endocrinol Metab Clin North Am. 2017;46:1039-1059 pubmed publisher
    Vitamin D is critical in mineral homeostasis and skeletal health and plays a regulatory role in nonskeletal tissues. Vitamin D deficiency is associated with chronic inflammatory diseases, including diabetes and obesity, both strong risk ..
  32. Wang Q, Zhao H, Jiang J, Xu J, Xie W, Fu X, et al. Genetic Architecture of Natural Variation in Rice Nonphotochemical Quenching Capacity Revealed by Genome-Wide Association Study. Front Plant Sci. 2017;8:1773 pubmed publisher
    ..i>OsPsbS1 had specific and high-level expression in green tissues of rice. However, we didn't find significant function for OsPsbS2, the other rice PsbS homologue...
  33. Sun Y, Chen K, Imamura Kawasawa Y, Salzberg A, Cooper T, Caruso C, et al. Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene. PLoS ONE. 2017;12:e0186873 pubmed publisher
    ..formation could be considered as a consequence of cancer development and thus changes in normal or premalignant tissues which had been exposed to oral carcinogens such as Dibenzo[def,p]chrysene (DBP) may better serve as predictive ..
  34. Su P, Guan H, Zhang Y, Wang X, Gao L, Zhao Y, et al. Probing the Single Key Amino Acid Responsible for the Novel Catalytic Function of ent-Kaurene Oxidase Supported by NADPH-Cytochrome P450 Reductases in Tripterygium wilfordii. Front Plant Sci. 2017;8:1756 pubmed publisher
    ..wilfordii root, stem, leaf, and flower tissues. Co-expression of both a TwCPR and TwKO in yeast showed that TwCPR3 has a slightly better activity for providing ..
  35. Eckl J, Sima S, Marcus K, Lindemann C, Richter K. Hsp90-downregulation influences the heat-shock response, innate immune response and onset of oocyte development in nematodes. PLoS ONE. 2017;12:e0186386 pubmed publisher
    ..expressed immune response genes skr-5, dod-24 and clec-60 we observe that their activity in intestinal tissues is influenced by Hsp90-depletion. Instead, effects on the development are evident in both gonad arms...
  36. Akhtar A, Shah S, Sheikh A, Nasrullah A, Haq S, Ghazanfar H, et al. Sarcoma Arising from the Chest Wall : A Case Report. Cureus. 2017;9:e1604 pubmed publisher
    Chest wall contains a wide array of tissues ranging from soft tissues like skin and muscle to bone. A variety of sarcomas can present with a painful or painless mass, which often requires histological testing for diagnosis...
  37. Chikara S, Mamidi S, Sreedasyam A, Chittem K, Pietrofesa R, Zuppa A, et al. Flaxseed Consumption Inhibits Chemically Induced Lung Tumorigenesis and Modulates Expression of Phase II Enzymes and Inflammatory Cytokines in A/J Mice. Cancer Prev Res (Phila). 2018;11:27-37 pubmed publisher
    ..oxidative stress and inflammation in lung injury models and has shown anticancer effects for breast and prostate tissues. However, the chemopreventive potential of flaxseed remains unexplored for lung cancer...
  38. Passerini L, Bacchetta R. Forkhead-Box-P3 Gene Transfer in Human CD4+ T Conventional Cells for the Generation of Stable and Efficient Regulatory T Cells, Suitable for Immune Modulatory Therapy. Front Immunol. 2017;8:1282 pubmed publisher
    The development of novel approaches to control immune responses to self- and allogenic tissues/organs represents an ambitious goal for the management of autoimmune diseases and in transplantation...
  39. Zheng Q, Li Y, Zhang D, Cui X, Dai K, Yang Y, et al. ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats. Cell Death Dis. 2017;8:e3145 pubmed publisher
    ..level was lower in PCOS patients than that in healthy women, and it was also decreased in the serum and ovarian tissues of RU486-induced PCOS rats compared with the control rats...
  40. Morgan J, Morton H, Parker R. Nutrition of animal cells in tissue culture; initial studies on a synthetic medium. Proc Soc Exp Biol Med. 1950;73:1-8 pubmed
  41. Barbash S, Lorenzen E, Persson T, Huber T, Sakmar T. GPCRs globally coevolved with receptor activity-modifying proteins, RAMPs. Proc Natl Acad Sci U S A. 2017;114:12015-12020 pubmed publisher
    Receptor activity-modifying proteins (RAMPs) are widely expressed in human tissues and, in some cases, have been shown to affect surface expression or ligand specificity of G-protein-coupled receptors (GPCRs)...
  42. Zhu M, Zhang N, Tao W, Wang Z, He S. Pancreatic Tuberculosis with Vascular Involvement and Peritoneal Dissemination in a Young Man. Case Rep Med. 2017;2017:4396759 pubmed publisher
    ..Biopsies of pancreas, duodenum, lymph nodes, omentum, and adipose tissues were all performed, revealing tuberculosis infection in pancreas, hepatic portal vein infiltration, and ..
  43. Wang X, Bleher R, Wang L, Garcia J, Dudek S, Shekhawat G, et al. Imatinib Alters Agonists-mediated Cytoskeletal Biomechanics in Lung Endothelium. Sci Rep. 2017;7:14152 pubmed publisher
    ..as a size-selective barrier and tightly controls the fluid exchange from the circulation to the surrounding tissues. In this study, a multiplexed microscopy characterization is developed to study the spatio-temporal effects of ..
  44. Owen D, Fan J, Campioli E, Venugopal S, Midzak A, Daly E, et al. TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis. Biochem J. 2017;474:3985-3999 pubmed publisher
    ..with high affinity to cholesterol and numerous compounds, is expressed at high levels in steroid-synthesizing tissues, and mediates cholesterol import into mitochondria, which is the rate-limiting step in steroid formation...
  45. Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, et al. Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Cell Death Dis. 2017;8:e3153 pubmed publisher
    Circular RNAs (circRNAs) have been identified from various tissues and species, but their regulatory functions during developmental processes are not well understood...
  46. Olah G, Módis K, Töro G, Hellmich M, Szczesny B, Szabo C. Role of endogenous and exogenous nitric oxide, carbon monoxide and hydrogen sulfide in HCT116 colon cancer cell proliferation. Biochem Pharmacol. 2018;149:186-204 pubmed publisher
    ..We measured the expression of NO and CO and H2S generating enzymes in primary colon cancer tissues and HCT116 colon cancer cells, and evaluated the effect of their pharmacological inhibition or pharmacological ..
  47. Du M, Jacobsen C. Relative merits and limiting factors for x-ray and electron microscopy of thick, hydrated organic materials. Ultramicroscopy. 2018;184:293-309 pubmed publisher
    ..offers superior characteristics for imaging thicker specimen such as whole eukaryotic cells, thick-sectioned tissues, and organs...
  48. Voisin M, de Medina P, Mallinger A, Dalenc F, Huc Claustre E, Leignadier J, et al. Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor. Proc Natl Acad Sci U S A. 2017;114:E9346-E9355 pubmed publisher
    ..showed significant increased OCDO levels and greater ChEH and 11?HSD2 protein expression compared with normal tissues. The analysis of several human BC mRNA databases indicated that 11?HSD2 and ChEH overexpression correlated with a ..
  49. Wedenoja S, Khamaysi A, Shimshilashvili L, Anbtawe Jomaa S, Elomaa O, Toppari J, et al. A missense mutation in SLC26A3 is associated with human male subfertility and impaired activation of CFTR. Sci Rep. 2017;7:14208 pubmed publisher
    ..family 26 member 3 (SLC26A3) and cystic fibrosis transmembrane conductance regulator (CFTR) are crucial for many tissues including sperm and epithelia of the male reproductive tract...
  50. Paim R, Benjamin S, Rondina D, Marques M, Viana D, Gonzaga M, et al. Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia. Evid Based Complement Alternat Med. 2017;2017:6376173 pubmed publisher
    ..to normal values, and significantly inhibited the changes of lipid peroxidation and inflammation in the liver tissues. The renal parameters analyzed (urea and creatinine) altered by diet were reverted to normal values...
  51. Goldin A, Muzykewicz D, Dwek J, Mubarak S. The aetiology of the non-ossifying fibroma of the distal femur and its relationship to the surrounding soft tissues. J Child Orthop. 2017;11:373-379 pubmed publisher
    ..We aim to retrospectively evaluate patients with non-ossifying fibroma (NOF) of the distal femur by radiographs, CT and MRI, and to provide a theory describing the reasoning for the distal femur NOF's location and aetiology...
  52. Tang Y, Xie C, Zhang Y, Qin Y, Zhang W. Overexpression of mRNA-decapping enzyme 1a predicts disease-specific survival in malignant melanoma. Melanoma Res. 2017;: pubmed publisher
    ..The average relative mRNA level of DCP1A was significantly (P=0.002) higher in the MM tissues (0.159±0.007) than that shown in the BN tissues (0.122±0.009)...
  53. Vijayakumar N, Parikh P, Mian S, Tennant B, Grossman G, Albrecht B, et al. Donor cornea tissue in cases of drowning or water submersion: eye banks practice patterns and tissue outcomes. Cell Tissue Bank. 2018;19:1-8 pubmed publisher
    ..or submersion secondary to death) remains controversial due to limited evidence about the quality of these tissues. To assess the safety of donor corneal tissue from victims of water submersion, an investigation of eye banks' ..
  54. Jia H, Zhan L, Wang X, He X, Chen G, Zhang Y, et al. Transcriptome analysis of sheep oral mucosa response to Orf virus infection. PLoS ONE. 2017;12:e0186681 pubmed publisher
    ..the expression level of DEGs involved in apoptotic pathways, in order to reach a homeostasis of oral mucosa tissues during the exposure to ORFV infection...
  55. Papaccio F, Paino F, Regad T, Papaccio G, Desiderio V, Tirino V. Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer Development. Stem Cells Transl Med. 2017;: pubmed publisher
    ..In fact, MSCs are recruited to the site of wound healing to repair damaged tissues, an event that is also associated with tumorigenesis...
  56. Song Z, Shan B, Tang W. Evaluating the diffusive gradients in thin films technique for the prediction of metal bioaccumulation in plants grown in river sediments. J Hazard Mater. 2018;344:360-368 pubmed publisher
    ..There were significant negative correlations between the content of Ni in the plant tissues and the contents of the other metals...
  57. Wu N, Zhang Z, Zhou J, Sun Z, Deng Y, Lin G, et al. The biocompatibility studies of polymer dots on pregnant mice and fetuses. Nanotheranostics. 2017;1:261-271 pubmed publisher
    ..Distributions of Pdots on maternal major organs and tissues were examined in frozen tissue sections...
  58. Bick A, Wakimoto H, Kamer K, Sancak Y, Goldberger O, Axelsson A, et al. Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter. Proc Natl Acad Sci U S A. 2017;114:E9096-E9104 pubmed publisher
    ..RNA sequencing (RNA-seq) of Micu2-/- ventricular tissues revealed markedly reduced transcripts encoding the apelin receptor (Micu2-/- vs...
  59. He X, Gong F, Chen Y, Zhou Z, Gong Z, Gao X. Calreticulin Fragment 39-272 Promotes B16 Melanoma Malignancy through Myeloid-Derived Suppressor Cells In Vivo. Front Immunol. 2017;8:1306 pubmed publisher
    ..The B16-CRT-bearing mice showed increased Gr1+ MDSC infiltration in tumor tissues, accelerated proliferation of CD11b+Ly6G+Ly6Clow (G-MDSC) precursors in bone ..
  60. Faramarzi B, Lantz L, Lee D, Khamas W. Histological and functional characterizations of the digital cushion in Quarter horses. Can J Vet Res. 2017;81:285-291 pubmed
    ..The percentage of samples in which chondrocytes and adipose tissues were either present or absent was calculated...
  61. Good M, Montoya T, Shi H, Zhou J, Huang Y, Tang L, et al. Thermosensitive hydrogels deliver bioactive protein to the vaginal wall. PLoS ONE. 2017;12:e0186268 pubmed publisher
    ..Prior studies have shown the protease MMP-9, a key player of ECM degradation, is upregulated in vaginal tissues from both mice and women with POP...
  62. Hashimoto S, Tabuchi Y, Yurino H, Hirohashi Y, Deshimaru S, Asano T, et al. Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues. Sci Rep. 2017;7:14225 pubmed publisher
    ..M-side) and the endometrial side (E-side) of a human endometrioid adenocarcinoma with squamous differentiation tissues. We also analyzed spherogenic cultures derived from the same tissue to identify putative regulators of stemness ..
  63. Gajaria P, Maheshwari U, Borkar D, Dhar R, Pancholi V. Buccal Mucosa Exfoliative Cell Prussian Blue Stain Co-Relates with Iron Overload in ?-Thalassemia Major Patients. Indian J Hematol Blood Transfus. 2017;33:559-564 pubmed publisher
    Thalassemics require regular blood transfusion therapy leading to iron overload in the body tissues, which is a major cause of morbidity and mortality in these patients...
  64. Wilson C, Mann D, Borthwick L. Epigenetic reprogramming in liver fibrosis and cancer. Adv Drug Deliv Rev. 2017;121:124-132 pubmed publisher
    ..Furthermore, improved technologies for the detection of epigenetic markers from patients' blood and tissues will vastly improve diagnosis, treatment options and prognostic tracking...
  65. Powell R, Hayward C, Snelgrove C, Polverino K, Park L, Chauhan R, et al. Pilot parallel randomised controlled trial of protective socks against usual care to reduce skin tears in high risk people: 'STOPCUTS'. Pilot Feasibility Stud. 2017;3:43 pubmed publisher
    ..The epidermis may separate from the dermis or both layers from underlying tissues leaving a skin flap or total loss of tissue, which is painful and prone to infection...
  66. Al Kadhi O, Melchini A, Mithen R, Saha S. Development of a LC-MS/MS Method for the Simultaneous Detection of Tricarboxylic Acid Cycle Intermediates in a Range of Biological Matrices. J Anal Methods Chem. 2017;2017:5391832 pubmed publisher
    ..A method for simultaneous qualitative and quantitative analysis of TCA cycle intermediates in body fluids, tissues, and cultured cell lines of human origin was developed using a common C18 reversed-phase column by LC-MS/MS ..
  67. van Rees W, Vouga E, Mahadevan L. Growth patterns for shape-shifting elastic bilayers. Proc Natl Acad Sci U S A. 2017;114:11597-11602 pubmed publisher
    Inspired by the differential-growth-driven morphogenesis of leaves, flowers, and other tissues, there is increasing interest in artificial analogs of these shape-shifting thin sheets made of active materials that respond to environmental ..
  68. Yan Z, Jia J, Yan X, Shi H, Han Y. Arabidopsis KHZ1 and KHZ2, two novel non-tandem CCCH zinc-finger and K-homolog domain proteins, have redundant roles in the regulation of flowering and senescence. Plant Mol Biol. 2017;95:549-565 pubmed publisher
    ..Both KHZ1 and KHZ2 were ubiquitously expressed throughout the tissues of Arabidopsis...
  69. Poulon F, Mehidine H, Juchaux M, Varlet P, Devaux B, Pallud J, et al. Optical properties, spectral, and lifetime measurements of central nervous system tumors in humans. Sci Rep. 2017;7:13995 pubmed publisher
    ..diffuse glioma, meningioma and metastasis) were discriminated from healthy brain and meninx control tissues. A threshold value was found for the scattering and absorption coefficient between tumoral and healthy groups...
  70. Rawat P, Agarwal S, Tripathi S. Effect of Addition of Antifungal Agents on Physical and Biological Properties of a Tissue Conditioner: An In-Vitro Study. Adv Pharm Bull. 2017;7:485-490 pubmed publisher
    b>Purpose: Tissue conditioners are used for healing of abused oral tissues. They may harbour microorganisms causing oral diseases such as candidiasis compromising the health of the patient...
  71. Kumar D, Hassan M, Pattnaik N, Mohapatra N, Dixit M. Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancers. PLoS ONE. 2017;12:e0186977 pubmed publisher
    ..These results were validated by immunohistochemistry in cancer tissues (stomach, prostate, brain, colorectal)...
  72. Dana N, Sowers T, Karpiouk A, Vanderlaan D, EMELIANOV S. Optimization of dual-wavelength intravascular photoacoustic imaging of atherosclerotic plaques using Monte Carlo optical modeling. J Biomed Opt. 2017;22:1-12 pubmed publisher
    ..We utilized a Monte Carlo optical model to simulate IVPA excitation in coronary tissues, identifying optimal wavelengths for plaque characterization...
  73. Zattara E, Macagno A, Busey H, Moczek A. Development of functional ectopic compound eyes in scarabaeid beetles by knockdown of orthodenticle. Proc Natl Acad Sci U S A. 2017;114:12021-12026 pubmed publisher
    ..space and time, yet understanding how complexity and integration emerge from uniform, undifferentiated precursor tissues remains limited...
  74. Song G, Choi H, Kim Y, Choi J, Ryu C. Seed defense biopriming with bacterial cyclodipeptides triggers immunity in cucumber and pepper. Sci Rep. 2017;7:14209 pubmed publisher
    ..Mortality of the insect pest Spodoptera litura increased when larvae fed on SDB-treated cucumber tissues. Analysis of the causative bacterial metabolites identified a leucine-proline cyclodipeptide and a commercially ..
  75. Scott I, Umair S, Savoian M, Simpson H. Abomasal dysfunction and cellular and mucin changes during infection of sheep with larval or adult Teladorsagia circumcincta. PLoS ONE. 2017;12:e0186752 pubmed publisher
    ..b>Tissues collected at necropsy were fixed in Bouin's fluid for light microscopy, immunocytochemistry and mucin staining ..
  76. Tortarolo M, Lo Coco D, Veglianese P, Vallarola A, Giordana M, Marcon G, et al. Amyotrophic Lateral Sclerosis, a Multisystem Pathology: Insights into the Role of TNF?. Mediators Inflamm. 2017;2017:2985051 pubmed publisher
    ..Changes in TNF? levels are reported in blood, cerebrospinal fluid, and nerve tissues of ALS patients and animal models...
  77. Kang J, Lee D, Park S, Ha J, Kim J, Ha G, et al. Cognitive Function of Artemisia argyi H. Fermented by Monascus purpureus under TMT-Induced Learning and Memory Deficits in ICR Mice. Evid Based Complement Alternat Med. 2017;2017:5809370 pubmed publisher
    ..After behavioral tests, brain tissues were extracted to assess damage to brain tissue...
  78. Fourbon Y, Gueguinou M, Felix R, Constantin B, Uguen A, Fromont G, et al. Ca2+ protein alpha 1D of CaV1.3 regulates intracellular calcium concentration and migration of colon cancer cells through a non-canonical activity. Sci Rep. 2017;7:14199 pubmed publisher
    ..3 channel is overexpressed in colorectal cancer biopsies compared to normal tissues. Gene silencing experiments targeting ?1D reduced the migration and the basal cytosolic Ca2+ ..
  79. Camkurt M, Güneş S, Coşkun S, Fındıklı E. Peripheral Signatures of Psychiatric Disorders: MicroRNAs. Clin Psychopharmacol Neurosci. 2017;15:313-319 pubmed publisher
    ..There are numerous studies performed in peripheral tissues for psychiatric disorders...
  80. Hine C, Mitchell J. Endpoint or Kinetic Measurement of Hydrogen Sulfide Production Capacity in Tissue Extracts. Bio Protoc. 2017;7: pubmed publisher
    Hydrogen sulfide (H2S) gas is produced in cells and tissues via various enzymatic processes...
  81. Hadley E, Richardson L, Torloni M, Menon R. Gestational tissue inflammatory biomarkers at term labor: A systematic review of literature. Am J Reprod Immunol. 2018;79: pubmed publisher
    Parturition at term is characterized by inflammatory overload in both feto-maternal tissues. Despite the large number of individual studies on changes in inflammatory biomarkers linked to labor, a comprehensive profile of them in each of ..
  82. Yoo Y, Tang L, Brosch T, Li D, Kolind S, Vavasour I, et al. Deep learning of joint myelin and T1w MRI features in normal-appearing brain tissue to distinguish between multiple sclerosis patients and healthy controls. Neuroimage Clin. 2018;17:169-178 pubmed publisher
    ..focal lesions are the most visible signs of MS pathology on conventional MRI, it has been shown that even tissues that appear normal may exhibit decreased myelin content as revealed by myelin-specific images (i.e., myelin maps)...
  83. Li R, Zheng K, Yuan C, Chen Z, Huang M. Be Active or Not: the Relative Contribution of Active and Passive Tumor Targeting of Nanomaterials. Nanotheranostics. 2017;1:346-357 pubmed publisher
    ..The relative contribution of the EPR effect and the receptor-mediated targeting to NM accumulation in tumor tissues has not been clearly defined yet. Here, we tackle this fundamental issue by reviewing previous studies...
  84. He T, Zhang L, Kong Y, Huang Y, Zhang Y, Zhou D, et al. Long non-coding RNA CASC15 is upregulated in hepatocellular carcinoma and facilitates hepatocarcinogenesis. Int J Oncol. 2017;51:1722-1730 pubmed publisher
    ..The expression of CASC15 in HCC tissues was quantitated by the reverse-transcription quantitative polymerase chain reaction, which showed that CASC15 was ..
  85. Weiss P. Experiments on cell and axon orientation in vitro; the role of colloidal exudates in tissue organization. J Exp Zool. 1945;100:353-86 pubmed
  86. Chitgupi U, Qin Y, Lovell J. Targeted Nanomaterials for Phototherapy. Nanotheranostics. 2017;1:38-58 pubmed publisher
    Phototherapies involve the irradiation of target tissues with light. To further enhance selectivity and potency, numerous molecularly targeted photosensitizers and photoactive nanoparticles have been developed...
  87. Lawson J, Glenn W. Multiple oncogenic viruses are present in human breast tissues before development of virus associated breast cancer. Infect Agent Cancer. 2017;12:55 pubmed publisher
    ..Here we demonstrate that these four viruses may be present in normal and benign breast tissues 1 to 11 years before the development of same virus breast cancer in the same patients.
  88. Nanjappa M, Medrano T, Prins G, Chen H, Zirkin B, Cooke P. Transdifferentiation of adult rat stem Leydig cells into prostatic and uterine epithelium, but not epidermis. Andrology. 2017;5:1165-1173 pubmed publisher
    ..Various types of stem cells have shown the ability to differentiate into other tissues, but there is no information on the plasticity of adult rat SLCs (rSLCs)...