Research Topics
Genomes and Genes | hemoperfusionSummarySummary: Removal of toxins or metabolites from the circulation by the passing of blood, within a suitable extracorporeal circuit, over semipermeable microcapsules containing adsorbents (e.g., activated charcoal) or enzymes, other enzyme preparations (e.g., gel-entrapped microsomes, membrane-free enzymes bound to artificial carriers), or other adsorbents (e.g., various resins, albumin-conjugated agarose). Top Publications
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Publications
- Uriu K, Osajima A, Hiroshige K, Watanabe H, Aibara K, Inada Y, et al. Endotoxin removal by direct hemoperfusion with an adsorbent column using polymyxin B-immobilized fiber ameliorates systemic circulatory disturbance in patients with septic shock. Am J Kidney Dis. 2002;39:937-47 pubmedDirect hemoperfusion (DHP) with an adsorbent column using polymyxin B-immobilized fiber (PMX-F) has been shown to improve the state of shock in patients with septic shock...
- Ueno T, Sugino M, Nemoto H, Shoji H, Kakita A, Watanabe M. Effect over time of endotoxin adsorption therapy in sepsis. Ther Apher Dial. 2005;9:128-36 pubmed..In recent years, endotoxin adsorption therapy (PMX-DHP, polymyxin-direct hemoperfusion) has been widely used in Japan to remove endotoxin, a causative agent of sepsis...
- Koo J, Kim J, Yoon J, Kim G, Jeon R, Kim H, et al. Failure of continuous venovenous hemofiltration to prevent death in paraquat poisoning. Am J Kidney Dis. 2002;39:55-9 pubmed..The amount ingested was 2.1 +/- 1.0 mouthfuls (as 20% concentrate). All patients were treated with hemoperfusion (HP; duration, 6.4 +/- 3...
- Kojika M, Sato N, Yaegashi Y, Suzuki Y, Suzuki K, Nakae H, et al. Endotoxin adsorption therapy for septic shock using polymyxin B-immobilized fibers (PMX): evaluation by high-sensitivity endotoxin assay and measurement of the cytokine production capacity. Ther Apher Dial. 2006;10:12-8 pubmed..The 28-day mortality rate was 12%. PMX-direct hemoperfusion (PMX-DHP) was associated with elevation of the mean arterial pressure and urine output, reduction in the mean ..
- Nakamura T, Kawagoe Y, Matsuda T, Shoji H, Ueda Y, Tamura N, et al. Effect of polymyxin B-immobilized fiber on blood metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels in acute respiratory distress syndrome patients. Blood Purif. 2004;22:256-60 pubmed..01, TIMP-1 220.6 +/- 30.5 ng/ml, p < 0.01). These data suggest that MMP-9 and TIMP-1 may play a role in the pathogenesis of ARDS and that PMX-F treatment ameliorated increased MMP-9 and TIMP-1 levels in ARDS patients. ..
- Nakamura T, Ushiyama C, Suzuki Y, Osada S, Inoue T, Shoji H, et al. Hemoperfusion with polymyxin B-immobilized fiber in septic patients with methicillin-resistant Staphylococcus aureus-associated glomerulonephritis. Nephron Clin Pract. 2003;94:c33-9 pubmed..PMX-F treatment may be effective in reducing urinary protein and urinary podocyte excretion in septic patients with MRSA-associated glomerulonephritis. ..
- Nakamura T, Kawagoe Y, Matsuda T, Ebihara I, Koide H. Effects of polymyxin B-immobilized fiber hemoperfusion on amino acid imbalance in septic encephalopathy. Blood Purif. 2003;21:282-6 pubmed..acids is altered in patients with septic encephalopathy and whether polymyxin B-immobilized fiber (PMX-F) hemoperfusion affects this balance...
- Kushi H, Miki T, Okamaoto K, Nakahara J, Saito T, Tanjoh K. Early hemoperfusion with an immobilized polymyxin B fiber column eliminates humoral mediators and improves pulmonary oxygenation. Crit Care. 2005;9:R653-61 pubmedThe objective of this study was to clarify the efficacy and mechanism of action of direct hemoperfusion with an immobilized polymyxin B fiber column (DHP-PMX) in patients with acute lung injury or acute respiratory distress syndrome ..
- Vincent J, Laterre P, Cohen J, Burchardi H, Bruining H, Lerma F, et al. A pilot-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection. Shock. 2005;23:400-5 pubmedEndotoxin is an important pathogenic trigger for sepsis. The polymyxin B-immobilized endotoxin removal hemoperfusion cartridge, Toraymyxin (hereafter PMX), has been shown to remove endotoxin in preclinical and open-label clinical studies...
- Uriu K, Osajima A, Kamochi M, Watanabe H, Aibara K, Kaizu K. The severity of hyperdynamic circulation may predict the effects of direct hemoperfusion with the adsorbent column using polymyxin B-immobilized fiber in patients with gram-negative septic shock. Ther Apher. 2001;5:25-30 pubmedIt has been reported that direct hemoperfusion with the adsorbent column using polymyxin B-immobilized fiber (DHP with PMX-F column) ameliorates hyperdynamic circulation in septic shock and improves survival rate...
- Ono S, Tsujimoto H, Matsumoto A, Ikuta S, Kinoshita M, Mochizuki H. Modulation of human leukocyte antigen-DR on monocytes and CD16 on granulocytes in patients with septic shock using hemoperfusion with polymyxin B-immobilized fiber. Am J Surg. 2004;188:150-6 pubmedb>Hemoperfusion with PMX-F (polymyxin B covalently immobilized on fibers) has been reported to be safe and effective for patients with septic shock. However, the molecular mechanism of this usefulness is not yet clear...
- Novelli G, Ferretti G, Ruberto F, Morabito V, Pugliese F. Early management of endotoxemia using the endotoxin activity assay and polymyxin B-based hemoperfusion. Contrib Nephrol. 2010;167:91-101 pubmed publisherWe evaluated the ability of the endotoxin activity (EA) assay to determine the need for early intervention for endotoxemia using polymyxin B-based hemoperfusion (PMX-DHP) on septic patients.
- Baumer W, Mertens A, Braun M, Kietzmann M. The isolated perfused bovine uterus as a model for mucous membrane irritation and inflammation. ALTEX. 2002;19:57-63 pubmed..In conclusion, the isolated perfused bovine uterus seems to be a promising in vitro model for mucous membrane irritancy as well as for inflammatory reactions. ..
- Kushi H, Miki T, Nakahara J, Okamoto K, Saito T, Tanjoh K. Hemoperfusion with an immobilized polymyxin B column reduces the blood level of neutrophil elastase. Blood Purif. 2006;24:212-7 pubmedWe investigated whether direct hemoperfusion with an immobilized polymyxin B column (DHP with PMX) could reduce the blood level of neutrophil elastase. 20 sepsis patients were enrolled in the study...
- Sato N, Kojima K, Horio Y, Goto E, Masunaga A, Ichiyasu H, et al. Successful treatment of severe amiodarone pulmonary toxicity with polymyxin B-immobilized fiber column direct hemoperfusion. Chest. 2013;143:1146-1150 pubmed publisher..Polymyxin B-immobilized fiber column direct hemoperfusion (PMX-DHP) is a medical device that reduces blood endotoxin levels in sepsis...
- Tojimbara T, Sato S, Nakajima I, Fuchinoue S, Akiba T, Teraoka S. Polymyxin B-immobilized fiber hemoperfusion after emergency surgery in patients with chronic renal failure. Ther Apher Dial. 2004;8:286-92 pubmedThe purpose of this study was to evaluate the effect of direct hemoperfusion using a Polymyxin B (PMX) immobilized fiber column in septic patients with chronic renal failure after emergency surgery...
- Tsushima K, Kubo K, Koizumi T, Yamamoto H, Fujimoto K, Hora K, et al. Direct hemoperfusion using a polymyxin B immobilized column improves acute respiratory distress syndrome. J Clin Apher. 2002;17:97-102 pubmed..We have studied whether direct hemoperfusion using a polymyxin B immobilized fiber column (PMX-DHP) is effective for acute lung injury (ALI) and ARDS...
- Hong S, Yang J, Lee E, Kim S. Effect of haemoperfusion on plasma paraquat concentration in vitro and in vivo. Toxicol Ind Health. 2003;19:17-23 pubmed..3+/-19.9 versus 67.2+/-19.2%, P <0.01), we concluded that adequate HP appears to be an indispensable treatment for patients with acute PQ poisoning. ..
- Kushi H, Nakahara J, Miki T, Okamoto K, Saito T, Tanjo K. Hemoperfusion with an immobilized polymyxin B fiber column inhibits activation of vascular endothelial cells. Ther Apher Dial. 2005;9:303-7 pubmed..We therefore investigated whether direct hemoperfusion (DHP) with a polymyxin B immobilized fiber column (PMX) could reduce the level of plasminogen activator ..
- Sato T, Shoji H, Koga N. Endotoxin adsorption by polymyxin B immobilized fiber column in patients with systemic inflammatory response syndrome: the Japanese experience. Ther Apher Dial. 2003;7:252-8 pubmed..Further studies are needed to clarify the mechanisms of PMX treatment and to strengthen the scientific basis of this treatment. ..
- Ronco C. The place of early haemoperfusion with polymyxin B fibre column in the treatment of sepsis. Crit Care. 2005;9:631-3 pubmed..This commentary considers whether the available evidence allows us to establish an appropriate role for PMX-F treatment in sepsis and what further work is needed. ..
- Nemoto H, Nakamoto H, Okada H, Sugahara S, Moriwaki K, Arai M, et al. Newly developed immobilized polymyxin B fibers improve the survival of patients with sepsis. Blood Purif. 2001;19:361-8; discussion 368-9 pubmed..However, in severe sepsis, this therapy does not improve the survival rate. ..
- Cruz D, Perazella M, Bellomo R, De Cal M, Polanco N, Corradi V, et al. Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review. Crit Care. 2007;11:R47 pubmed..We performed a systematic review to describe the effect in septic patients of direct hemoperfusion with PMX-F on outcomes of blood pressure, use of vasoactive drugs, oxygenation, and mortality reported in ..
- Tsujimoto H, Ono S, Hiraki S, Majima T, Kawarabayashi N, Sugasawa H, et al. Hemoperfusion with polymyxin B-immobilized fibers reduced the number of CD16+ CD14+ monocytes in patients with septic shock. J Endotoxin Res. 2004;10:229-37 pubmedCD16+ CD14+ monocytes dramatically increase in number in patients with severe infection. Hemoperfusion with PMX-F (direct hemoperfusion with polymyxin B immobilized fibers) has been reported to be a safe and effective treatment for ..
- Yamamoto T, Ono T, Ito T, Yamanoi A, Maruyama I, Tanaka T. Hemoperfusion with a high-mobility group box 1 adsorption column can prevent the occurrence of hepatic ischemia-reperfusion injury in rats. Crit Care Med. 2010;38:879-85 pubmed publisher..b>Hemoperfusion therapy using a cellulofine sulfate bead column (high-mobility group box 1 adsorption column) was performed ..
- Yantasee W, Fryxell G, Porter G, Pattamakomsan K, Sukwarotwat V, Chouyyok W, et al. Novel sorbents for removal of gadolinium-based contrast agents in sorbent dialysis and hemoperfusion: preventive approaches to nephrogenic systemic fibrosis. Nanomedicine. 2010;6:1-8 pubmed publisher..those of activated carbon and zirconium phosphate currently used in the state-of-the-art sorbent dialysis and hemoperfusion systems...
- Nakamura T, Sugaya T, Koide H. Urinary liver-type fatty acid-binding protein in septic shock: effect of polymyxin B-immobilized fiber hemoperfusion. Shock. 2009;31:454-9 pubmed publisher..in patients with septic shock or severe sepsis without shock and whether polymyxin B-immobilized fiber (PMX-F) hemoperfusion affects these levels...
- Murakami M, Miyauchi Y, Nishida M, Okada H, Hamano K. Direct hemoperfusion using polymyxin-B immobilized fiber for septic shock after cardiac surgery. Circ J. 2009;73:658-61 pubmedThe factors contributing to the efficacy and outcome of direct hemoperfusion using polymyxin-B immobilized fiber (PMX-DHP) after cardiac surgery were investigated...
- Schmidt D, Neale J, Olson K. Clinical course of a fatal ingestion of diquat. J Toxicol Clin Toxicol. 1999;37:881-4 pubmed..We describe multiple metabolic abnormalities, an apparent artifact introduced by diquat in the laboratory assay for serum creatinine, serum diquat levels, and the need for emergency airway management. ..
- Kumagai T, Takeyama N, Yabuki T, Harada M, Miki Y, Kanou H, et al. Apheresis of activated leukocytes with an immobilized polymyxin B filter in patients with septic shock. Shock. 2010;34:461-6 pubmed publisherIn this study, we examined the effects of direct hemoperfusion through filters with immobilized polymyxin B (PMX-DHP) on leukocyte function and plasma levels of cytokines in patients with septic shock...
- Wood S. Use of charcoal hemoperfusion. Crit Care Nurse. 2002;22:18, 20; author reply 20 pubmed
- Estrera A, Rubenstein F, Miller C, Huynh T, Letsou G, Safi H. Descending thoracic aortic aneurysm: surgical approach and treatment using the adjuncts cerebrospinal fluid drainage and distal aortic perfusion. Ann Thorac Surg. 2001;72:481-6 pubmed
- Shalkham A, Kirrane B, Hoffman R, Goldfarb D, Nelson L. The availability and use of charcoal hemoperfusion in the treatment of poisoned patients. Am J Kidney Dis. 2006;48:239-41 pubmedCharcoal hemoperfusion (CHP) has been one of the preferred methods to enhance the elimination of certain toxins in selected poisoned patients...
- Erguven M, Yilmaz O, Deveci M, Aksu N, Dursun F, Pelit M, et al. Mushroom poisoning. Indian J Pediatr. 2007;74:847-52 pubmed..We aimed to review characteristics of mushrooms and mushroom poisoning and compare clinical picture, laboratory data, treatment modalities and prognostic factors in children with amanita intoxication and non-amanita mushroom poisoning...
- Thanacoody R. Extracorporeal elimination in acute valproic acid poisoning. Clin Toxicol (Phila). 2009;47:609-16 pubmed publisher..b>Hemoperfusion also enhances VPA elimination, but its effectiveness may be limited by column saturation...
- Oda S, Hirasawa H, Shiga H, Nakanishi K, Matsuda K, Nakamura M, et al. Cytokine adsorptive property of various adsorbents in immunoadsorption columns and a newly developed adsorbent: an in vitro study. Blood Purif. 2004;22:530-6 pubmed..Selective cytokine adsorption columns could be developed with improvement of currently available adsorbents. Such a new selective cytokine adsorption column could be clinically applied for the treatment of SIRS/sepsis. ..
- Chang T. Artificial cells containing detoxicants. 1972 [classical article]. Artif Cells Blood Substit Immobil Biotechnol. 2002;30:457-68 pubmed
- Kanno Y, Suzuki H. Selection of modality in continuous renal replacement therapy. Contrib Nephrol. 2010;166:167-72 pubmed publisherContinuous hemoperfusion therapies are now widely used in critical care, and could prove to be life-saving for patients unable to receive regular hemoperfusion treatments...
- Lai D, Wang J, Yao J, Wang Y, Cheng G. [The assessment of hemoperfusion for the treatment of acute methamidophos poisoning]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2011;29:440-2 pubmedTo explore the effect of hemoperfusion(HP) about the patients of methamidophos poisoning...
- Naruse K, Sakai Y, Natori T, Guo L, Shindoh J, Iida Y, et al. Xenogeneic direct hemoperfusion using whole swine liver for liver failure in dogs. J Surg Res. 2003;111:229-35 pubmedWe developed a new method of xenogeneic direct hemoperfusion of a bioartificial liver support system consisting of a leukocyte-adsorbent column, an immunoglobulin-adsorbent column, and the substitute unit for hepatic function...
- Kanesaka S, Sasaki J, Kuzume M, Narihara K, Takahashi Y. Effect of direct hemoperfusion using polymyxin B immobilized fiber on inflammatory mediators in patients with severe sepsis and septic shock. Int J Artif Organs. 2008;31:891-7 pubmedThe objective of this study was to investigate retrospectively the effect of direct hemoperfusion using polymyxin B immobilized fiber (PMX-DHP) in a cartridge to remove endotoxin on inflammatory mediators in septic patients...
- Shimizu T, Hanasawa K, Sato K, Umeki M, Koga N, Naganuma T, et al. Direct hemoperfusion with polymyxin-B-immobilized fiber columns improves septic hypotension and reduces inflammatory mediators in septic patients with colorectal perforation. Langenbecks Arch Surg. 2009;394:303-11 pubmed publisherAlthough some studies have reported favorable effects of direct hemoperfusion with polymyxin-B-immobilized fiber columns (PMX) for the treatment of septic shock, few studies have demonstrated the efficacy of PMX in studies with a uniform ..
- Jung J, Eo E, Ahn K. A case of hemoperfusion and L-carnitine management in valproic acid overdose. Am J Emerg Med. 2008;26:388.e3-4 pubmed publisher..We report a patient with VPA overdose who was treated successfully with hemoperfusion with activated charcoal and L-carnitine...
- Gao Y, Chen Y, Deng H, Zhong F, Li Y. [Evaluation of charcoal hemoperfusion in dogs with acute fluoroacetamide poisoning]. Zhonghua Er Ke Za Zhi. 2007;45:661-4 pubmed..During the recent ten years the authors treated children with severe FAM poisoning with charcoal hemoperfusion (HP) and achieved better results...
- Sakka S, Kuethe F, Demme U, Huttemann E. [Intoxication with a tricyclic antidepressant]. Anaesthesist. 2007;56:581-6 pubmed..No life-threatening arrhythmia occurred at any time. On the advice of the poison information center, hemoperfusion was performed for extracorporeal elimination...
- Naruse K, Makuuchi M. Development and perspectives of bioartificial liver support. Hepatogastroenterology. 2002;49:91-5 pubmed..We developed a new system of xenogeneic direct hemoperfusion consisting of a leukocyte adsorbent, an immunoglobulin adsorbent, and a substitute unit for hepatic function, ..
- Cao N, Yu Y, Wang M, Chen C. In vitro study of a novel low-density lipoprotein adsorbent. Artif Cells Blood Substit Immobil Biotechnol. 2002;30:53-61 pubmed
- Meyer S, Kuhlmann M, Peters F, Limbach H, Lindinger A. Severe valproic acid intoxication is associated with atrial tachycardia: secondary detoxication by hemoperfusion. Klin Padiatr. 2005;217:82-5 pubmed..Secondary detoxication by hemodialysis or hemoperfusion has been employed successfully in valproic acid intoxication...
- Macia M, Avilés J, Navarro J, Morales S, Garcia J. Efficacy of molecular adsorbent recirculating system for the treatment of intractable pruritus in cholestasis. Am J Med. 2003;114:62-4 pubmed
- Hou G, Liu T, Wang H, Fu G, Yuan Z, Liu B, et al. Preparation of adsorbents for the removal of endotoxin. Artif Cells Blood Substit Immobil Biotechnol. 2005;33:227-37 pubmed..ligand and hexamethylendiamine as the spacer, was the best in adsorption capacity and was selected for hemoperfusion on rabbits...
- Ushida H, Koizumi S, Johnin K, Katoh K, Okada Y. [Experience of direct hemoperfusion using polymyxin B-immobilized fiber on patients with endotoxin shock from urosepsis]. Hinyokika Kiyo. 2001;47:329-31 pubmedWe report the effects of direct hemoperfusion using polymyxin B-immobilized fiber (PMX treatment) on two patients with endotoxin shock from urosepsis...
- Park S, Lee S, Park S, Gil H, Lee E, Yang J, et al. Concurrent Hemoperfusion and Hemodialysis in Patients with Acute Pesticide Intoxication. Blood Purif. 2016;42:329-336 pubmed..chemicals in the pesticide formulation may be eliminated more effectively in time if hemodialysis (HD) and hemoperfusion (HP) are performed concurrently...