proton therapy


Summary: The use of an external beam of PROTONS as radiotherapy.

Top Publications

  1. Giantsoudi D, Seco J, Eaton B, Simeone F, Kooy H, Yock T, et al. Evaluating Intensity Modulated Proton Therapy Relative to Passive Scattering Proton Therapy for Increased Vertebral Column Sparing in Craniospinal Irradiation in Growing Pediatric Patients. Int J Radiat Oncol Biol Phys. 2017;98:37-46 pubmed publisher
    ..delivering vertebral body sparing (VBS) versus WVB CSI with passively scattered (PS) and intensity modulated proton therapy (IMPT) in growing children treated for medulloblastoma...
  2. Kralik S, Watson G, Shih C, Ho C, Finke W, Buchsbaum J. Radiation-Induced Large Vessel Cerebral Vasculopathy in Pediatric Patients With Brain Tumors Treated With Proton Radiation Therapy. Int J Radiat Oncol Biol Phys. 2017;99:817-824 pubmed publisher
    ..Further studies are necessary to determine potential risk factors for large vessel vasculopathy with proton radiation therapy in comparison with conventional photon radiation therapy. ..
  3. Angi M, Kalirai H, Taktak A, Hussain R, Groenewald C, Damato B, et al. Prognostic biopsy of choroidal melanoma: an optimised surgical and laboratory approach. Br J Ophthalmol. 2017;101:1143-1146 pubmed publisher
  4. Leeman J, Romesser P, Zhou Y, McBride S, Riaz N, Sherman E, et al. Proton therapy for head and neck cancer: expanding the therapeutic window. Lancet Oncol. 2017;18:e254-e265 pubmed publisher
    ..In this Review, we attempt to define the role of this method in the contemporary multidisciplinary management of various types of head and neck cancer. ..
  5. Riechardt A, Karle B, Cordini D, Heufelder J, Budach V, Joussen A, et al. Proton therapy of iris melanoma with 50 CGE : Influence of target volume on clinical outcome. Strahlenther Onkol. 2017;193:943-950 pubmed publisher
    ..Sector-based irradiation revealed a higher risk for local recurrence, but selected patients with well-circumscribed iris melanoma benefit from applying a lesion-based target volume when treated with sector-based PBT. ..
  6. Jones B. Proton beam therapy for medulloblastoma. Lancet Oncol. 2016;17:e173 pubmed publisher
  7. Chang J, Verma V, Li M, Zhang W, Komaki R, Lu C, et al. Proton Beam Radiotherapy and Concurrent Chemotherapy for Unresectable Stage III Non-Small Cell Lung Cancer: Final Results of a Phase 2 Study. JAMA Oncol. 2017;3:e172032 pubmed publisher
    ..Further optimization of proton therapy, particularly intensity-modulated proton therapy, is still needed.
  8. Davuluri R, Jiang W, Fang P, Xu C, Komaki R, Gomez D, et al. Lymphocyte Nadir and Esophageal Cancer Survival Outcomes After Chemoradiation Therapy. Int J Radiat Oncol Biol Phys. 2017;99:128-135 pubmed publisher
    ..This observation provides a rationale to prospectively test chemotherapeutic and radiation treatment strategies that may have a lower impact on host immunity. ..
  9. Weber D, Murray F, Correia D, Bolsi A, Frei Welte M, Pica A, et al. Pencil beam scanned protons for the treatment of patients with Ewing sarcoma. Pediatr Blood Cancer. 2017;64: pubmed publisher
    ..exist regarding the clinical outcome of patients with Ewing sarcoma (EWS) treated with pencil beam scanning proton therapy (PT)...

More Information


  1. Rwigema J, Verma V, Lin L, Berman A, Levin W, Evans T, et al. Prospective study of proton-beam radiation therapy for limited-stage small cell lung cancer. Cancer. 2017;123:4244-4251 pubmed publisher
    ..In the first prospective registry study and largest analysis to date of PBT for LS-SCLC, PBT was found to be safe with a limited incidence of high-grade toxicities. Cancer 2017;123:4244-4251. © 2017 American Cancer Society. ..
  2. Noble D, Ajithkumar T, Lambert J, Gleeson I, Williams M, Jefferies S. Highly Conformal Craniospinal Radiotherapy Techniques Can Underdose the Cranial Clinical Target Volume if Leptomeningeal Extension through Skull Base Exit Foramina is not Contoured. Clin Oncol (R Coll Radiol). 2017;29:439-447 pubmed publisher was to assess plan quality and dose coverage of posterior cranial fossa foramina with both photon and proton therapy. We analysed the radiotherapy plans of seven patients treated with CSI for medulloblastoma and primitive neuro-..
  3. Mohan R, Peeler C, Guan F, Bronk L, Cao W, Grosshans D. Radiobiological issues in proton therapy. Acta Oncol. 2017;56:1367-1373 pubmed publisher
    ..In the clinical practice of proton therapy, the RBE is assumed to have a fixed value of 1.1...
  4. Jones B. Patterns of failure after proton therapy in medulloblastoma. Int J Radiat Oncol Biol Phys. 2014;90:25-6 pubmed publisher
  5. Chang J, Kestin L, Barriger R, Chetty I, Ginsburg M, Kumar S, et al. ACR Appropriateness Criteria® nonsurgical treatment for locally advanced non-small-cell lung cancer: good performance status/definitive intent. Oncology (Williston Park). 2014;28:706-10, 712, 714 passim pubmed
    ..In instances in which evidence is lacking or not definitive, expert opinion may be used as the basis for recommending imaging or treatment. ..
  6. Gold A, Murray T, Markoe A, Ehlies F, Latiff A, Wildner A, et al. Uveal melanoma gene expression status post radiotherapy. Optom Vis Sci. 2014;91:e14-7 pubmed
    ..Gene expression profiling for uveal melanoma may be obtained from patients who were previously treated with radiotherapy; however, the implication of these results will benefit from ongoing clinical evaluation. ..
  7. Brower J, Indelicato D, Aldana P, Sandler E, Rotondo R, Mendenhall N, et al. A treatment planning comparison of highly conformal radiation therapy for pediatric low-grade brainstem gliomas. Acta Oncol. 2013;52:594-9 pubmed publisher
  8. Niedzielski J, Yang J, Mohan R, Titt U, Mirkovic D, Stingo F, et al. Differences in Normal Tissue Response in the Esophagus Between Proton and Photon Radiation Therapy for Non-Small Cell Lung Cancer Using In Vivo Imaging Biomarkers. Int J Radiat Oncol Biol Phys. 2017;99:1013-1020 pubmed publisher
    ..any significant difference in normal tissue toxicity between intensity modulated radiation therapy (IMRT) or proton therapy for the treatment of non-small cell lung cancer...
  9. Chang J, Zhang X, Knopf A, Li H, Mori S, Dong L, et al. Consensus Guidelines for Implementing Pencil-Beam Scanning Proton Therapy for Thoracic Malignancies on Behalf of the PTCOG Thoracic and Lymphoma Subcommittee. Int J Radiat Oncol Biol Phys. 2017;99:41-50 pubmed publisher
    Pencil-beam scanning (PBS) proton therapy (PT), particularly intensity modulated PT, represents the latest advanced PT technology for treating cancers, including thoracic malignancies...
  10. Yeung R, Chapman T, Bowen S, Apisarnthanarax S. Proton beam therapy for hepatocellular carcinoma. Expert Rev Anticancer Ther. 2017;17:911-924 pubmed publisher
    ..Future studies, including ongoing randomized cooperative group trials, will aim to determine the incremental benefit of PBT over photons and which patients are most suitable for PBT. ..
  11. Suzuki N, Azami A, Todate Y, Tada T, Waragai M, Honda M, et al. [A Case of Perianal Squamous Cell Carcinoma with Left Inguinal Lymph Node Metastasis That Showed a Complete Response More Than Five Years after Chemotherapy and Concomitant Proton Beam Therapy]. Gan To Kagaku Ryoho. 2017;44:525-528 pubmed
    ..The tumor disappeared completely 1 month after this treatment, and biopsy specimens confirmed the absence of any viable cancer cells. The patient has been alive with no sign of recurrence for 5 years. ..
  12. Sellam A, Coscas F, Lumbroso Le Rouic L, Dendale R, Lupidi M, Coscas G, et al. Optical Coherence Tomography Angiography of Macular Features After Proton Beam Radiotherapy for Small Choroidal Melanoma. Am J Ophthalmol. 2017;181:12-19 pubmed publisher
    ..0001). Patients treated with PBR for CM (with 100% of the dose given to the macula) present major changes at both plexuses but also a vascular rarefaction of the choriocapillaris. ..
  13. Hua C, Yao W, Kidani T, Tomida K, Ozawa S, Nishimura T, et al. A robotic C-arm cone beam CT system for image-guided proton therapy: design and performance. Br J Radiol. 2017;90:20170266 pubmed publisher
    ..Our novel gantry-independent robotic CBCT system provides high-accuracy volumetric image guidance for proton therapy. Advances in knowledge: Ceiling-mounted robotic CBCT provides a viable option than CT on-rails for partial ..
  14. Oshiro Y, Mizumoto M, Okumura T, Sugahara S, Fukushima T, Ishikawa H, et al. Clinical results of proton beam therapy for advanced neuroblastoma. Radiat Oncol. 2013;8:142 pubmed publisher
    ..PBT may be a better alternative to photon radiotherapy for children with advanced neuroblastoma, and may be conducted safely for patients with neuroblastoma that is difficult to manage using photon beams. ..
  15. Grosshans D, Mohan R, Gondi V, Shih H, Mahajan A, Brown P. The role of image-guided intensity modulated proton therapy in glioma. Neuro Oncol. 2017;19:ii30-ii37 pubmed publisher
    ..For patients with both favorable and unfavorable prognoses, intensity modulated proton therapy (IMPT) may offer significant, yet unproven benefits...
  16. Amini A, Raben D, Crawford E, Flaig T, Kessler E, Lam E, et al. Patient characterization and usage trends of proton beam therapy for localized prostate cancer in the United States: A study of the National Cancer Database. Urol Oncol. 2017;35:438-446 pubmed publisher
    ..2%). PBT for men with localized prostate cancer significantly increased in the United States from 2004 to 2013. Significant demographic and prognostic differences between those men treated with photons and protons were identified. ..
  17. Thariat J, Maschi C, Lanteri S, Peyrichon M, Baillif S, Herault J, et al. Dry Eye Syndrome After Proton Therapy of Ocular Melanomas. Int J Radiat Oncol Biol Phys. 2017;98:142-151 pubmed publisher
    To investigate whether proton therapy (PT) performs safely in superotemporal melanomas, in terms of risk of dry-eye syndrome (DES)...
  18. Ning M, Tang L, Gomez D, Xu T, Luo Y, Huo J, et al. Incidence and Predictors of Pericardial Effusion After Chemoradiation Therapy for Locally Advanced Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys. 2017;99:70-79 pubmed publisher
    ..effusion (PCE) in patients enrolled in a phase 2 prospective randomized study of intensity modulated RT versus proton therapy for locally advanced NSCLC...
  19. Lee C, Lee S, Lee S, Song H, Kim D, Cho S, et al. Monte Carlo simulation of secondary neutron dose for scanning proton therapy using FLUKA. PLoS ONE. 2017;12:e0186544 pubmed publisher
    b>Proton therapy is a rapidly progressing field for cancer treatment. Globally, many proton therapy facilities are being commissioned or under construction...
  20. Rancati T, Palorini F, Cozzarini C, Fiorino C, Valdagni R. Understanding urinary toxicity after radiotherapy for prostate cancer: first steps forward. Tumori. 2017;103:395-404 pubmed publisher
    ..The first results of these trials allow initial attempts at predictive modeling, which can serve as a basis for the optimization of patient selection and treatment planning...
  21. Blanchard P, Frank S. [Proton therapy for head and neck cancers]. Cancer Radiother. 2017;21:515-520 pubmed publisher
    The absence of exit dose and the sharp lateral penumbra are key assets for proton therapy, which are responsible for its dosimetric superiority over advanced photon radiotherapy...
  22. Sanford N, Yeap B, Larvie M, Daartz J, Munzenrider J, Liebsch N, et al. Prospective, Randomized Study of Radiation Dose Escalation With Combined Proton-Photon Therapy for Benign Meningiomas. Int J Radiat Oncol Biol Phys. 2017;99:787-796 pubmed publisher
    ..Further investigation is needed to better define the risk of late toxicities, including CVA after cranial radiation therapy. ..
  23. Hoppe B, Bryant C, Sandler H. Radiation for prostate cancer: intensity modulated radiation therapy versus proton beam. J Urol. 2015;193:1089-91 pubmed publisher
  24. Høyer M, Muren L, Glimelius B. The evolution of radiotherapy techniques in the management of prostate cancer. Acta Oncol. 2015;54:821-4 pubmed publisher
  25. Xie Y, Bentefour E, Janssens G, Smeets J, Vander Stappen F, Hotoiu L, et al. Prompt Gamma Imaging for In Vivo Range Verification of Pencil Beam Scanning Proton Therapy. Int J Radiat Oncol Biol Phys. 2017;99:210-218 pubmed publisher was used to record the prompt gamma signal emitted along the proton tracks during delivery of proton therapy for a brain cancer patient...
  26. Xi M, Lin S. Recent advances in intensity modulated radiotherapy and proton therapy for esophageal cancer. Expert Rev Anticancer Ther. 2017;17:635-646 pubmed publisher
    ..and clinical outcomes of intensity-modulated radiation therapy (IMRT), volumetric modulated arc therapy, proton therapy, and four-dimensional radiotherapy for esophageal cancer, and discusses the challenges and future development ..
  27. Matet A, Daruich A, Zografos L. Radiation Maculopathy After Proton Beam Therapy for Uveal Melanoma: Optical Coherence Tomography Angiography Alterations Influencing Visual Acuity. Invest Ophthalmol Vis Sci. 2017;58:3851-3861 pubmed publisher
    ..012), respectively, were associated with worse VA. VA of eyes with radiation maculopathy is influenced by structural and microvascular factors identified with OCTA, including FAZ area and DCP integrity. ..
  28. Giandini T, Tenconi C, Carrara M, Ciocca M, Russo S, Panaino C, et al. Physicists' views on hadrontherapy: a survey of members of the Italian Association of Medical Physics (AIFM). Tumori. 2017;103:430-437 pubmed publisher
    ..The survey was digitally submitted to the 991 members between the end of January and the beginning of April 2016...
  29. Vogel J, Lin L, Simone C, Berman A. Risk of major cardiac events following adjuvant proton versus photon radiation therapy for patients with thymic malignancies. Acta Oncol. 2017;56:1060-1064 pubmed publisher
    ..04). DS-PBT results in decreased dose to OARs and may reduce the risk of MCEs compared with IMRT. Long-term follow-up is required to assess for clinical benefit from DS-PBT. ..
  30. Shen C, Hu C, Ladra M, Narang A, Pollack C, Terezakis S. Socioeconomic factors affect the selection of proton radiation therapy for children. Cancer. 2017;123:4048-4056 pubmed publisher
    ..This study examined the impact of race and socioeconomic factors on the use of proton therapy in children with solid malignancies.
  31. Resch A, Landry G, Kamp F, Cabal G, Belka C, Wilkens J, et al. Quantification of the uncertainties of a biological model and their impact on variable RBE proton treatment plan optimization. Phys Med. 2017;36:91-102 pubmed publisher
    ..Firstly, intensity modulated proton therapy TPs assuming constant RBE were derived, and subsequently the variable RBE weighted dose (RWD), including the ..
  32. Thariat J, Jacob S, Caujolle J, Maschi C, Baillif S, Angellier G, et al. Cataract Avoidance With Proton Therapy in Ocular Melanomas. Invest Ophthalmol Vis Sci. 2017;58:5378-5386 pubmed publisher
    ..Contrary to other forms of radiotherapy, proton therapy (PT) can spare all or part of the lens due to accurate dose deposition...
  33. Verma V, Simone C, Mishra M. Quality of Life and Patient-Reported Outcomes Following Proton Radiation Therapy: A Systematic Review. J Natl Cancer Inst. 2018;110: pubmed publisher
    ..Evaluating quality of life (QOL) and patient-reported outcomes (PROs) is essential to establishing PBT's "value" in oncologic therapy. The goal of this systematic review was to assess QOL and PROs in patients treated with PBT...
  34. Zhang Y, Huth I, Wegner M, Weber D, Lomax A. Surface as a motion surrogate for gated re-scanned pencil beam proton therapy. Phys Med Biol. 2017;62:4046-4061 pubmed publisher
    ..effectiveness and treatment efficiency of surface motion guided gating of pencil beam scanning (PBS) proton therapy for liver tumour treatments...
  35. Vogel J, Lin L, Litzky L, Berman A, Simone C. Predicted Rate of Secondary Malignancies Following Adjuvant Proton Versus Photon Radiation Therapy for Thymoma. Int J Radiat Oncol Biol Phys. 2017;99:427-433 pubmed publisher
    ..compared with photon radiation therapy after resection of stage II thymic malignancies to determine whether proton therapy improves the risk-benefit ratio...
  36. Mohan R, Das I, Ling C. Empowering Intensity Modulated Proton Therapy Through Physics and Technology: An Overview. Int J Radiat Oncol Biol Phys. 2017;99:304-316 pubmed publisher
    Considering the clinical potential of protons attributable to their physical characteristics, interest in proton therapy has increased greatly in this century, as has the number of proton therapy installations...
  37. Demizu Y, Mizumoto M, Onoe T, Nakamura N, Kikuchi Y, Shibata T, et al. Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in Japan. Cancer Sci. 2017;108:972-977 pubmed publisher
    ..1%]). No treatment-related deaths occurred. Proton beam therapy is safe and effective for the treatment of bone sarcomas of the skull base and spine in Japan. However, larger prospective studies with a longer follow-up are warranted. ..
  38. Berman A, Teo B, Dolney D, Swisher McClure S, Shahnazi K, Both S, et al. An in-silico comparison of proton beam and IMRT for postoperative radiotherapy in completely resected stage IIIA non-small cell lung cancer. Radiat Oncol. 2013;8:144 pubmed publisher
    ..This study reports an in-silico comparative analysis of passive scattering proton therapy (PSPT)- and intensity modulated proton therapy (IMPT) with intensity modulated photon beam radiotherapy (IMRT) ..
  39. Crellin A, Burnet N. Proton beam therapy: the context, future direction and challenges become clearer. Clin Oncol (R Coll Radiol). 2014;26:736-8 pubmed publisher
  40. Hong T, Wo J, Borger D, Yeap B, McDonnell E, Willers H, et al. Phase II Study of Proton-Based Stereotactic Body Radiation Therapy for Liver Metastases: Importance of Tumor Genotype. J Natl Cancer Inst. 2017;109: pubmed publisher
    ..KRAS mutation is a strong predictor of poor LC, stressing the need for tumor genotyping prior to SBRT and treatment intensification in this patient subset. ..
  41. Demizu Y, Jin D, Sulaiman N, Nagano F, Terashima K, Tokumaru S, et al. Particle Therapy Using Protons or Carbon Ions for Unresectable or Incompletely Resected Bone and Soft Tissue Sarcomas of the Pelvis. Int J Radiat Oncol Biol Phys. 2017;98:367-374 pubmed publisher
    ..Nevertheless, a longer follow-up period is needed to confirm these results. ..
  42. Azria D, Bourgier C, Brengues M. One Size Fits All: Does the Dogma Stand in Radiation Oncology?. EBioMedicine. 2016;10:19-20 pubmed publisher