boron neutron capture therapy

Summary

Summary: A technique for the treatment of neoplasms, especially gliomas and melanomas in which boron-10, an isotope, is introduced into the target cells followed by irradiation with thermal neutrons.

Top Publications

  1. Suzuki M, Endo K, Satoh H, Sakurai Y, Kumada H, Kimura H, et al. A novel concept of treatment of diffuse or multiple pleural tumors by boron neutron capture therapy (BNCT). Radiother Oncol. 2008;88:192-5 pubmed publisher
    ..one with malignant pleural mesothelioma and one with a malignant short spindle cell tumor, received boron neutron capture therapy (BNCT). In each case, the tumors regressed or remained stable in size for 3-6 months following BNCT...
  2. Kawabata S, Miyatake S, Nonoguchi N, Hiramatsu R, Iida K, Miyata S, et al. Survival benefit from boron neutron capture therapy for the newly diagnosed glioblastoma patients. Appl Radiat Isot. 2009;67:S15-8 pubmed publisher
    Since 2002-2007, we applied boron neutron capture therapy (BNCT) to >50 cases of malignant gliomas (MGs) with epithermal neutron irradiations...
  3. Stenstam B, Pellettieri L, Sorteberg W, Rezaei A, Sköld K. BNCT for recurrent intracranial meningeal tumours - case reports. Acta Neurol Scand. 2007;115:243-7 pubmed
    The investigation was designed to explore the efficacy of boron neutron capture therapy (BNCT) as treatment for recurrent intracranial meningeal tumours.
  4. Justus E, Awad D, Hohnholt M, Schaffran T, Edwards K, Karlsson G, et al. Synthesis, liposomal preparation, and in vitro toxicity of two novel dodecaborate cluster lipids for boron neutron capture therapy. Bioconjug Chem. 2007;18:1287-93 pubmed
    ..liposomes are of high potential value as transporters of boron to tumor cells in treatments based on boron neutron capture therapy (BNCT). Liposomes prepared from B-6-14 were slightly less toxic in V79 Chinese hamster cells (IC50 5...
  5. Ito Y, Kimura Y, Shimahara T, Ariyoshi Y, Shimahara M, Miyatake S, et al. Disposition of TF-PEG-Liposome-BSH in tumor-bearing mice. Appl Radiat Isot. 2009;67:S109-10 pubmed publisher
    ..Results confirmed that (10)B concentration is higher in the TPLB group than in the BSH group and that TPLB is significantly effective as boron delivery system...
  6. Riley K, Binns P, Harling O, Albritton J, Kiger W, Rezaei A, et al. An international dosimetry exchange for BNCT part II: computational dosimetry normalizations. Med Phys. 2008;35:5419-25 pubmed
    The meaningful sharing and combining of clinical results from different centers in the world performing boron neutron capture therapy (BNCT) requires improved precision in dose specification between programs...
  7. Wu G, Barth R, Yang W, Lee R, Tjarks W, Backer M, et al. Boron containing macromolecules and nanovehicles as delivery agents for neutron capture therapy. Anticancer Agents Med Chem. 2006;6:167-84 pubmed
    b>Boron neutron capture therapy (BNCT) is based on the nuclear capture and fission reactions that occur when non-radioactive boron-10 is irradiated with low energy thermal neutrons to yield high linear energy transfer (LET) alpha particles ..
  8. Wittig A, Michel J, Moss R, Stecher Rasmussen F, Arlinghaus H, Bendel P, et al. Boron analysis and boron imaging in biological materials for Boron Neutron Capture Therapy (BNCT). Crit Rev Oncol Hematol. 2008;68:66-90 pubmed publisher
    b>Boron Neutron Capture Therapy (BNCT) is based on the ability of the stable isotope 10B to capture neutrons, which leads to a nuclear reaction producing an alpha- and a 7Li-particle, both having a high biological effectiveness and a very ..
  9. Yamamoto T, Nakai K, Matsumura A. Boron neutron capture therapy for glioblastoma. Cancer Lett. 2008;262:143-52 pubmed publisher
    b>Boron neutron capture therapy (BNCT) theoretically allows the preferential destruction of tumor cells while sparing the normal tissue, even if the cells have microscopically spread to the surrounding normal brain...

More Information

Publications62

  1. Kamida A, Fujita Y, Kato I, Iwai S, Ono K, Suzuki M, et al. Effect of neutron capture therapy on the cell cycle of human squamous cell carcinoma cells. Int J Radiat Biol. 2008;84:191-9 pubmed publisher
    The effects of boronophenylalanine (BPA)-mediated boron neutron capture therapy (BNCT) on the growth potential and cell cycle of human oral squamous cell carcinoma (SCC) cells were examined...
  2. Pisarev M, Dagrosa M, Juvenal G. Boron neutron capture therapy in cancer: past, present and future. Arq Bras Endocrinol Metabol. 2007;51:852-6 pubmed
    ..b>Boron neutron capture therapy (BNCT) is based on the selective uptake of certain boron non-radioactive compounds by a tumor, and the ..
  3. Backer M, Gaynutdinov T, Patel V, Bandyopadhyaya A, Thirumamagal B, Tjarks W, et al. Vascular endothelial growth factor selectively targets boronated dendrimers to tumor vasculature. Mol Cancer Ther. 2005;4:1423-9 pubmed
    Tumor neovasculature is a potential but, until very recently, unexplored target for boron neutron capture therapy (BNCT) of cancer...
  4. Pietrangeli D, Ricciardi G. Neutral and polyanionic carboranylporphyrazines: synthesis and physico-chemical properties. Appl Radiat Isot. 2009;67:S97-S100 pubmed publisher
    Among the challenges precluding the widespread use of boron neutron capture therapy (BNCT) has been the difficulty in achieving selective delivery of large quantities of boron to malignant cells...
  5. Kabalka G, Yao M, Marepally S, Chandra S. Biological evaluation of boronated unnatural amino acids as new boron carriers. Appl Radiat Isot. 2009;67:S374-9 pubmed publisher
    There is a pressing need for new and more efficient boron delivery agents to tumor cells for use in boron neutron capture therapy (BNCT)...
  6. Altieri S, Balzi M, Bortolussi S, Bruschi P, Ciani L, Clerici A, et al. Carborane derivatives loaded into liposomes as efficient delivery systems for boron neutron capture therapy. J Med Chem. 2009;52:7829-35 pubmed publisher
    b>Boron neutron capture therapy (BNCT) is an anticancer therapy based on the incorporation of (10)B in tumors, followed by neutron irradiation...
  7. Miyata S, Kawabata S, Hiramatsu R, Doi A, Ikeda N, Yamashita T, et al. Computed tomography imaging of transferrin targeting liposomes encapsulating both boron and iodine contrast agents by convection-enhanced delivery to F98 rat glioma for boron neutron capture therapy. Neurosurgery. 2011;68:1380-7; discussion 1387 pubmed publisher
    To achieve potent tumor-selective antitumor efficacy by boron neutron capture therapy (BNCT), it is important to have a significant differential uptake of 10B between tumor cells and normal cells...
  8. Faião Flores F, Coelho P, Arruda Neto J, Camillo M, Maria Engler S, Rici R, et al. Boron uptake in normal melanocytes and melanoma cells and boron biodistribution study in mice bearing B16F10 melanoma for boron neutron capture therapy. Radiat Environ Biophys. 2012;51:319-29 pubmed publisher
    Information on (10)B distribution in normal tissues is crucial to any further development of boron neutron capture therapy (BNCT)...
  9. Lin Y, Hwang J, Wang S, Yang B, Chang C, Hsiao M, et al. Macro- and microdistributions of boron drug for boron neutron capture therapy in an animal model. Anticancer Res. 2012;32:2657-64 pubmed
    ..blood, rather than in normal tissue, is often used as the reference to calculate the BC in tumor for boron neutron capture therapy (BNCT)...
  10. Kimura Y, Ariyoshi Y, Shimahara M, Miyatake S, Kawabata S, Ono K, et al. Boron neutron capture therapy for recurrent oral cancer and metastasis of cervical lymph node. Appl Radiat Isot. 2009;67:S47-9 pubmed publisher
    ..The clinical response in our patients ranged from CR to PD. In 5 cases, spontaneous pain decreased immediately after BNCT. Three of the 6 are alive at the time of writing and we found that BNCT contributed to QOL improvement in all...
  11. Alkins R, Brodersen P, Sodhi R, Hynynen K. Enhancing drug delivery for boron neutron capture therapy of brain tumors with focused ultrasound. Neuro Oncol. 2013;15:1225-35 pubmed publisher
    ..Therapies need to penetrate the CNS but avoid collateral tissue injury. Boron neutron capture therapy (BNCT) is a treatment whereby a (10)B-containing drug preferentially accumulates in malignant cells ..
  12. Faião Flores F, Coelho P, Muniz R, Souza G, Arruda Neto J, Maria D. Antitumor potential induction and free radicals production in melanoma cells by Boron Neutron Capture Therapy. Appl Radiat Isot. 2011;69:1748-51 pubmed publisher
    Antiproliferative and oxidative damage effects occurring in Boron Neutron Capture Therapy (BNCT) in normal fibroblasts and melanoma cell lines were analyzed...
  13. Riley K, Binns P, Harling O, Kiger W, González S, Casal M, et al. Unifying dose specification between clinical BNCT centers in the Americas. Med Phys. 2008;35:1295-8 pubmed
    A dosimetry intercomparison between the boron neutron capture therapy groups of the Massachusetts Institute of Technology (MIT) and the Comisión Nacional de Energía Atómica (CNEA), Argentina was performed to enable combined analyses ..
  14. Winum J, Cecchi A, Montero J, Innocenti A, Scozzafava A, Supuran C. Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic. Bioorg Med Chem Lett. 2005;15:3302-6 pubmed
    ..inhibitors with high affinity for the tumor-associated CA isozymes may lead to important advances in boron neutron capture therapy (BNCT) applications targeting such tumors, which are non-responsive to both classical chemo- and ..
  15. Kawabata S, Miyatake S, Hiramatsu R, Hirota Y, Miyata S, Takekita Y, et al. Phase II clinical study of boron neutron capture therapy combined with X-ray radiotherapy/temozolomide in patients with newly diagnosed glioblastoma multiforme--study design and current status report. Appl Radiat Isot. 2011;69:1796-9 pubmed publisher
    Recently, we reported our clinical experiences of boron neutron capture therapy (BNCT) for the newly diagnosed glioblastoma...
  16. Harling O. Fission reactor based epithermal neutron irradiation facilities for routine clinical application in BNCT--Hatanaka memorial lecture. Appl Radiat Isot. 2009;67:S7-11 pubmed publisher
    ..Some comments are provided on the current status of reactor versus accelerator based epithermal neutron sources for BNCT. This paper concludes with a summary and a few personal observations on BNCT by the author. ..
  17. Barth R, Joensuu H. Boron neutron capture therapy for the treatment of glioblastomas and extracranial tumours: as effective, more effective or less effective than photon irradiation?. Radiother Oncol. 2007;82:119-22 pubmed
  18. Pitois A, de las Heras L, Zampolli A, Menichetti L, Carlos R, Lazzerini G, et al. Capillary electrophoresis-electrospray mass spectrometry and HR-ICP-MS for the detection and quantification of 10B-boronophenylalanine (10B-BPA) used in boron neutron capture therapy. Anal Bioanal Chem. 2006;384:751-60 pubmed
    b>Boron neutron capture therapy (BNCT) is a bimodal radiotherapeutic treatment based on the irradiation of neoplastic tissues with neutrons after the tissues have selectively accumulated molecules loaded with nuclides with large neutron ..
  19. Miyatake S, Kawabata S, Yokoyama K, Kuroiwa T, Michiue H, Sakurai Y, et al. Survival benefit of Boron neutron capture therapy for recurrent malignant gliomas. J Neurooncol. 2009;91:199-206 pubmed publisher
    We have applied boron neutron capture therapy (BNCT) to malignant brain tumors. Here we evaluated the survival benefit of BNCT for recurrent malignant glioma (MG). Since 2002, we have treated 22 cases of recurrent MG with BNCT...
  20. Kankaanranta L, Seppälä T, Koivunoro H, Välimäki P, Beule A, Collan J, et al. L-boronophenylalanine-mediated boron neutron capture therapy for malignant glioma progressing after external beam radiation therapy: a Phase I study. Int J Radiat Oncol Biol Phys. 2011;80:369-76 pubmed publisher
    To investigate the safety of boronophenylalanine-mediated boron neutron capture therapy (BNCT) in the treatment of malignant gliomas that progress after surgery and conventional external beam radiation therapy.
  21. Henriksson R, Capala J, Michanek A, Lindahl S, Salford L, Franzen L, et al. Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA). Radiother Oncol. 2008;88:183-91 pubmed publisher
    To evaluate the efficacy and safety of boron neutron capture therapy (BNCT) for glioblastoma multiforme (GBM) using a novel protocol for the boronophenylalanine-fructose (BPA-F) infusion...
  22. Suzuki M, Sakurai Y, Masunaga S, Kinashi Y, Nagata K, Maruhashi A, et al. A preliminary experimental study of boron neutron capture therapy for malignant tumors spreading in thoracic cavity. Jpn J Clin Oncol. 2007;37:245-9 pubmed
    The purpose of the present study is to verify the treatment effects of boron neutron capture therapy (BNCT) in ectopic tumors implanted in the thoracic cavity mimicking malignant pleural mesothelioma (MPM)...
  23. Perona M, Pontiggia O, Carpano M, Thomasz L, Thorp S, Pozzi E, et al. In vitro studies of cellular response to DNA damage induced by boron neutron capture therapy. Appl Radiat Isot. 2011;69:1732-6 pubmed publisher
    ..Different cellular responses were observed for each irradiated group. The decrease of Ku70 in the neutrons +BOPP group could play a role in the increase of sensitization to radiation. ..
  24. Menichetti L, De Marchi D, Calucci L, Ciofani G, Menciassi A, Forte C. Boron nitride nanotubes for boron neutron capture therapy as contrast agents in magnetic resonance imaging at 3 T. Appl Radiat Isot. 2011;69:1725-7 pubmed publisher
    ..The r(2) value was comparable to those of commercial superparamagnetic iron oxide nanoparticles, indicating that Fe-containing BNNTs have the potential to be used as T(2) contrast-enhancement agents in MRI at 3T. ..
  25. Kawabata S, Hiramatsu R, Kuroiwa T, Ono K, Miyatake S. Boron neutron capture therapy for recurrent high-grade meningiomas. J Neurosurg. 2013;119:837-44 pubmed publisher
    ..In this study, the authors used boron neutron capture therapy (BNCT), a tumor-selective intensive particle radiation modality, to treat high-grade meningioma...
  26. Kimura Y, Ariyoshi Y, Miyatake S, Shimahara M, Kawabata S, Ono K. Boron neutron capture therapy for papillary cystadenocarcinoma in the upper lip: a case report. Int J Oral Maxillofac Surg. 2009;38:293-5 pubmed publisher
    b>Boron neutron capture therapy (BNCT) is a tumor-selective radiation therapy using alpha and (7)Li particles, which are produced by the reaction of neutron with boron ((10)B), and taken up by the tumor...
  27. Fuwa N, Suzuki M, Sakurai Y, Nagata K, Kinashi Y, Masunaga S, et al. Treatment results of boron neutron capture therapy using intra-arterial administration of boron compounds for recurrent head and neck cancer. Br J Radiol. 2008;81:749-52 pubmed publisher
    The effect of boron neutron capture therapy (BNCT) is correlated with the density of boron in the tumour. BNCT using intra-arterial administration of boron compounds was performed for recurrent head and neck cancer...
  28. Nakagawa N, Akai F, Fukawa N, Fujita Y, Suzuki M, Ono K, et al. Early effects of boron neutron capture therapy on rat glioma models. Brain Tumor Pathol. 2007;24:7-13 pubmed
    Early effects of boron neutron capture therapy (BNCT) on malignant glioma are characterized by reduction of the enhancement area and regression of the peritumoral edema radiologically...
  29. Kageji T, Mizobuchi Y, Nagahiro S, Nakagawa Y, Kumada H. Clinical results of boron neutron capture therapy (BNCT) for glioblastoma. Appl Radiat Isot. 2011;69:1823-5 pubmed publisher
    ..1%, 17.4% and 5.8%, respectively. This clinical result of BNCT in patients with GBM is superior to that of single treatment of conventional radiotherapy compared with historical data of conventional treatment. ..
  30. Kato I, Fujita Y, Maruhashi A, Kumada H, Ohmae M, Kirihata M, et al. Effectiveness of boron neutron capture therapy for recurrent head and neck malignancies. Appl Radiat Isot. 2009;67:S37-42 pubmed publisher
    ..b>Boron neutron capture therapy (BNCT) is tumor-cell targeted radiotherapy that has significant superiority over conventional ..
  31. Aihara T, Hiratsuka J, Morita N, Uno M, Sakurai Y, Maruhashi A, et al. First clinical case of boron neutron capture therapy for head and neck malignancies using 18F-BPA PET. Head Neck. 2006;28:850-5 pubmed
    We investigated the application of boron neutron capture therapy (BNCT) to suitable cancers other than glioblastoma and melanoma. Head and neck malignancies were consequently selected as adaptable cancers...
  32. Aiyama H, Nakai K, Yamamoto T, Nariai T, Kumada H, Ishikawa E, et al. A clinical trial protocol for second line treatment of malignant brain tumors with BNCT at University of Tsukuba. Appl Radiat Isot. 2011;69:1819-22 pubmed publisher
    We have evaluated the efficacy and safety of boron neutron capture therapy (BNCT) for recurrent glioma and malignant brain tumor using a new protocol...
  33. Dagrosa M, Crivello M, Perona M, Thorp S, Santa Cruz G, Pozzi E, et al. First evaluation of the biologic effectiveness factors of boron neutron capture therapy (BNCT) in a human colon carcinoma cell line. Int J Radiat Oncol Biol Phys. 2011;79:262-8 pubmed publisher
    DNA lesions produced by boron neutron capture therapy (BNCT) and those produced by gamma radiation in a colon carcinoma cell line were analyzed...
  34. Uusi Simola J, Heikkinen S, Kotiluoto P, Serèn T, Seppälä T, Auterinen I, et al. MAGIC polymer gel for dosimetric verification in boron neutron capture therapy. J Appl Clin Med Phys. 2007;8:114-23 pubmed
    ..The measured and normalized dose distribution in the epithermal neutron beam was compared to the dose distribution calculated by computer simulation. The results support the feasibility MAGIC gel in BNCT dosimetry. ..
  35. Crossley E, Ziolkowski E, Coderre J, Rendina L. Boronated DNA-binding compounds as potential agents for boron neutron capture therapy. Mini Rev Med Chem. 2007;7:303-13 pubmed
    b>Boron Neutron Capture Therapy (BNCT) is a binary cancer treatment that exploits the short range particles released from a nuclear fission reaction involving the non-radioactive 10B nucleus and low-energy (thermal) neutrons for the ..
  36. Hsieh C, Chen Y, Chen F, Hwang J, Chen J, Liu R, et al. Evaluation of pharmacokinetics of 4-borono-2-(18)F-fluoro-L-phenylalanine for boron neutron capture therapy in a glioma-bearing rat model with hyperosmolar blood-brain barrier disruption. J Nucl Med. 2005;46:1858-65 pubmed
    ..3) may afford enough radiation doses to destroy the tumor cells while sparing the normal tissues in boron neutron capture therapy. The pharmacokinetic parameters of k(el), k(12), k(21), and V(1) for intracarotid injection of (18)F-..
  37. Faião Flores F, Coelho P, Toledo Arruda Neto J, Maria Engler S, Tiago M, Capelozzi V, et al. Apoptosis through Bcl-2/Bax and cleaved caspase up-regulation in melanoma treated by boron neutron capture therapy. PLoS ONE. 2013;8:e59639 pubmed publisher
    b>Boron neutron capture therapy (BNCT) is a binary treatment involving selective accumulation of boron carriers in a tumor followed by irradiation with a thermal or epithermal neutron beam...
  38. Barth R, Vicente M, Harling O, Kiger W, Riley K, Binns P, et al. Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer. Radiat Oncol. 2012;7:146 pubmed publisher
    b>Boron neutron capture therapy (BNCT) is a biochemically targeted radiotherapy based on the nuclear capture and fission reactions that occur when non-radioactive boron-10, which is a constituent of natural elemental boron, is irradiated ..
  39. Renner M, Miura M, Easson M, Vicente M. Recent progress in the syntheses and biological evaluation of boronated porphyrins for boron neutron-capture therapy. Anticancer Agents Med Chem. 2006;6:145-57 pubmed
    ..New delivery modalities have also greatly improved the targeting potential of compounds previously deemed unsuitable for applications in BNCT. ..
  40. Kageji T, Nagahiro S, Matsuzaki K, Mizobuchi Y, Toi H, Nakagawa Y, et al. Boron neutron capture therapy using mixed epithermal and thermal neutron beams in patients with malignant glioma-correlation between radiation dose and radiation injury and clinical outcome. Int J Radiat Oncol Biol Phys. 2006;65:1446-55 pubmed
    To clarify the correlation between the radiation dose and clinical outcome of sodium borocaptate-based intraoperative boron neutron capture therapy in patients with malignant glioma.
  41. Wang L, Wang S, Chu P, Ho C, Jiang S, Liu Y, et al. BNCT for locally recurrent head and neck cancer: preliminary clinical experience from a phase I/II trial at Tsing Hua Open-Pool Reactor. Appl Radiat Isot. 2011;69:1803-6 pubmed publisher
    ..fraction for 2 fractions at 30 day interval can be given with sustained blood boron concentration and tolerable early toxicities for recurrent H & N cancer. ..
  42. Detta A, Cruickshank G. L-amino acid transporter-1 and boronophenylalanine-based boron neutron capture therapy of human brain tumors. Cancer Res. 2009;69:2126-32 pubmed publisher
    ..p-boronophenylalanine (BPA) into cells and may play a major role in the effectiveness of BPA-based boron neutron capture therapy. The functional status of LAT-1 and its relationship to cell proliferation were simultaneously ..
  43. Kankaanranta L, Seppälä T, Koivunoro H, Saarilahti K, Atula T, Collan J, et al. Boron neutron capture therapy in the treatment of locally recurred head and neck cancer. Int J Radiat Oncol Biol Phys. 2007;69:475-82 pubmed
    ..We evaluated safety and efficacy of boron neutron capture therapy (BNCT) in the treatment of such cancers...
  44. Yokoyama K, Miyatake S, Kajimoto Y, Kawabata S, Doi A, Yoshida T, et al. Analysis of boron distribution in vivo for boron neutron capture therapy using two different boron compounds by secondary ion mass spectrometry. Radiat Res. 2007;167:102-9 pubmed
    The efficiency of boron neutron capture therapy (BNCT) for malignant gliomas depends on the selective and absolute accumulation of (10)B atoms in tumor tissues. Only two boron compounds, BPA and BSH, currently can be used clinically...
  45. Nakai K, Yamamoto T, Aiyama H, Takada T, Yoshida F, Kageji T, et al. Boron neutron capture therapy combined with fractionated photon irradiation for glioblastoma: a recursive partitioning analysis of BNCT patients. Appl Radiat Isot. 2011;69:1790-2 pubmed publisher
    ..4 months and 14.9 months. In the high risk patients (RPA class V), the median OS of the NCT(+) group tended to be better than that of NCT(-) group. 50% of BNCT patients were RPA class V. ..
  46. Cardoso J, Trivillin V, Heber E, Nigg D, Calzetta O, Blaumann H, et al. Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: towards a novel therapy for liver metastases. Int J Radiat Biol. 2007;83:699-706 pubmed
    The effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration was examined in the Wistar rat...
  47. Kumar S, Freytag S, Barton K, Burmeister J, Joiner M, Sedghi B, et al. A novel method of boron delivery using sodium iodide symporter for boron neutron capture therapy. J Radiat Res. 2010;51:621-6 pubmed
    b>Boron Neutron Capture Therapy (BNCT) effectiveness depends on the preferential sequestration of boron in cancer cells relative to normal tissue cells...
  48. Dagrosa M, Thomasz L, Longhino J, Perona M, Calzetta O, Blaumann H, et al. Optimization of boron neutron capture therapy for the treatment of undifferentiated thyroid cancer. Int J Radiat Oncol Biol Phys. 2007;69:1059-66 pubmed
    To analyze the possible increase in efficacy of boron neutron capture therapy (BNCT) for undifferentiated thyroid carcinoma (UTC) by using p-boronophenylalanine (BPA) plus 2,4-bis (alpha,beta-dihydroxyethyl)-deutero-porphyrin IX (BOPP) ..
  49. Barth R. Boron neutron capture therapy at the crossroads: challenges and opportunities. Appl Radiat Isot. 2009;67:S3-6 pubmed publisher
    Over the past 25 years research on boron neutron capture therapy (BNCT) has progressed relatively slowly but steadily with the greatest progress in the field of clinical studies...
  50. Miyatake S, Kawabata S, Nonoguchi N, Yokoyama K, Kuroiwa T, Matsui H, et al. Pseudoprogression in boron neutron capture therapy for malignant gliomas and meningiomas. Neuro Oncol. 2009;11:430-6 pubmed publisher
    ..We experienced a similar phenomenon in the treatment of malignant gliomas and meningiomas using boron neutron capture therapy (BNCT), a cell-selective form of particle radiation...
  51. Sakurai Y, Ono K, Miyatake S, Maruhashi A. Improvement effect on the depth-dose distribution by CSF drainage and air infusion of a tumour-removed cavity in boron neutron capture therapy for malignant brain tumours. Phys Med Biol. 2006;51:1173-83 pubmed
    b>Boron neutron capture therapy (BNCT) without craniotomy for malignant brain tumours was started using an epi-thermal neutron beam at the Kyoto University Reactor in June 2002...
  52. Chou F, Chung H, Liu H, Chi C, Lui W. Suitability of boron carriers for BNCT: accumulation of boron in malignant and normal liver cells after treatment with BPA, BSH and BA. Appl Radiat Isot. 2009;67:S105-8 pubmed publisher
    ..Therefore, boron neutron capture therapy (BNCT) may provide an alternative therapy for treatment of hepatocellular carcinoma...
  53. Sköld K, H Stenstam B, Diaz A, Giusti V, Pellettieri L, Hopewell J. Boron Neutron Capture Therapy for glioblastoma multiforme: advantage of prolonged infusion of BPA-f. Acta Neurol Scand. 2010;122:58-62 pubmed publisher
    To assess possible improved efficacy of Boron Neutron Capture Therapy (BNCT) for glioblastoma multiforme (GBM) using prolonged infusion and a correspondingly higher dose of l-boronophenylalanine, as the fructose complex (BPA-f).