heavy ion radiotherapy


Summary: The use of a heavy ion particle beam for radiotherapy, such as the HEAVY IONS of CARBON.

Top Publications

  1. Shiba S, Saitoh J, Irie D, Shirai K, Abe T, Kubota Y, et al. Potential Pitfalls of a Fiducial Marker-matching Technique in Carbon-ion Radiotherapy for Lung Cancer. Anticancer Res. 2017;37:5673-5680 pubmed
    ..To analyze the accuracy of patient positioning and dose distribution quality using a fiducial marker-matching technique in carbon-ion radiotherapy (C-ion RT) for stage I lung cancer...
  2. Wozny A, Lauret A, Battiston Montagne P, Guy J, Beuve M, Cunha M, et al. Differential pattern of HIF-1α expression in HNSCC cancer stem cells after carbon ion or photon irradiation: one molecular explanation of the oxygen effect. Br J Cancer. 2017;116:1340-1349 pubmed publisher
    ..Hypoxia-inducible factor-1α plays a main role in the response of CSCs and non-CSCs to carbon ion and photon irradiations, which makes the HIF-1α targeting an attractive therapeutic challenge. ..
  3. Yamazaki H, Demizu Y, Okimoto T, Ogita M, Himei K, Nakamura S, et al. Reirradiation for recurrent head and neck cancers using charged particle or photon radiotherapy. Strahlenther Onkol. 2017;193:525-533 pubmed publisher
    ..Tumor volume, primary site (nasopharyngeal), and prescribed dose were identified as survival factors. Younger patients with a larger PTV experienced toxicity grade ?3. ..
  4. Demizu Y, Jin D, Sulaiman N, Nagano F, Terashima K, Tokumaru S, et al. Particle Therapy Using Protons or Carbon Ions for Unresectable or Incompletely Resected Bone and Soft Tissue Sarcomas of the Pelvis. Int J Radiat Oncol Biol Phys. 2017;98:367-374 pubmed publisher
    ..Nevertheless, a longer follow-up period is needed to confirm these results. ..
  5. Saitoh J, Koto M, Demizu Y, Suefuji H, Ohno T, Tsuji H, et al. A Multicenter Study of Carbon-Ion Radiation Therapy for Head and Neck Adenocarcinoma. Int J Radiat Oncol Biol Phys. 2017;99:442-449 pubmed publisher
    ..C-ion RT resulted in excellent local control. C-ion RT could become a curative treatment option for HN adenocarcinoma with acceptable toxicities. ..
  6. Shirai K, Saitoh J, Musha A, Abe T, Kobayashi D, Takahashi T, et al. Prospective observational study of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck. Cancer Sci. 2017;108:2039-2044 pubmed publisher
    ..However, the late mucosal adverse events were not rare, and meticulous treatment planning is required. Trial registration no. UMIN000007886. ..
  7. Kasuya G, Kato H, Yasuda S, Tsuji H, Yamada S, Haruyama Y, et al. Progressive hypofractionated carbon-ion radiotherapy for hepatocellular carcinoma: Combined analyses of 2 prospective trials. Cancer. 2017;123:3955-3965 pubmed publisher
    ..8 Gy (RBE) in 4 fractions established as the recommended treatment course for eligible HCC patients. Cancer 2017;123:3955-65. © 2017 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. ..
  8. Prall M, Lehmann H, Prokesch H, Richter D, Graeff C, Kaderka R, et al. Treatment of arrhythmias by external charged particle beams: a Langendorff feasibility study. Biomed Tech (Berl). 2015;60:147-56 pubmed publisher
    ..Second, our pilot study seems to suggest that no adverse effects have to be expected immediately during heavy ion irradiation in performing subsequent experiments with doses of 30-60 Gy and intact pigs. ..
  9. Shiba S, Okonogi N, Kato S, Wakatsuki M, Kobayashi D, Kiyohara H, et al. Clinical Impact of Re-irradiation with Carbon-ion Radiotherapy for Lymph Node Recurrence of Gynecological Cancers. Anticancer Res. 2017;37:5577-5583 pubmed
    ..To evaluate the safety and efficacy of re-irradiation with carbon-ion radiotherapy (C-ion RT) for lymph node recurrence of gynecological cancers after definitive radiotherapy...

More Information


  1. Sato K, Azuma R, Imai T, Shimokawa T. Enhancement of mTOR signaling contributes to acquired X-ray and C-ion resistance in mouse squamous carcinoma cell line. Cancer Sci. 2017;108:2004-2010 pubmed publisher
    ..Moreover, we found that activated mTOR signaling contributes to X-ray and C-ion resistance in the X60 cancer cells. ..
  2. Autsavapromporn N, Liu C, Konishi T. Impact of Co-Culturing with Fractionated Carbon-Ion-Irradiated Cancer Cells on Bystander Normal Cells and Their Progeny. Radiat Res. 2017;188:335-341 pubmed publisher
    ..These results indicate that dose fractionation reduced the late effect of carbon-ion exposure in the progeny of bystander cells compared to the effect in the initial bystander cells. ..
  3. Wei W, He J, Wang J, Ding N, Wang B, Lin S, et al. Serum microRNAs as Early Indicators for Estimation of Exposure Degree in Response to Ionizing Irradiation. Radiat Res. 2017;188:342-354 pubmed publisher
    ..In conclusion, we have identified a set of miRNAs that are quite sensitive to different radiation types in the early stages after exposure, demonstrating their potential use as effective indicators to predict the degree of exposure. ..
  4. He Y, Zhang H, Li H, Zhang Y, Jia Q, Li Z, et al. Differential Proteomics Reveals the Potential Injury Mechanism Induced by Heavy Ion Radiation in Mice Ovaries. Biomed Environ Sci. 2017;30:301-307 pubmed publisher
    ..The proteomics and biochemical results provide insight into the underlying mechanisms of CIR toxicity in ovarian tissues. ..
  5. Zhou C, Rong Y, Konishi T, Xiang Z, Zihui F, Hong M. Effect of Carbon-Ion Radiation on Drug Transporters Organic Anion Transporting Polypeptides in Breast Cancer Cells. Radiat Res. 2017;187:689-700 pubmed publisher
    ..Therefore, heavy ions, such as carbon, can affect expression of drug transporters and show promise in facilitating the delivery of antitumor drugs with greater efficiency. ..
  6. Wakatsuki M, Kato S, Ohno T, Kiyohara H, Karasawa K, Tamaki T, et al. Difference in distant failure site between locally advanced squamous cell carcinoma and adenocarcinoma of the uterine cervix after C-ion RT. J Radiat Res. 2015;56:523-8 pubmed
    ..507). In conclusion, there were high rates of distant failure after C-ion RT in AC cases regardless of PLN status, and there were high rates of distant failure after C-ion RT, especially PALN failure, in SqCC cases with positive PLNs. ..
  7. Xie Y, Si J, Wang Y, Li H, Di C, Yan J, et al. E2F is involved in radioresistance of carbon ion induced apoptosis via Bax/caspase 3 signal pathway in human hepatoma cell. J Cell Physiol. 2018;233:1312-1320 pubmed publisher
    ..Our study provides a scientific rationale for the clinical use of heavy ion as radiotherapy in patients with p53-deficient tumors, which are often resistant to radiotherapy. ..
  8. Shirai K, Koto M, Demizu Y, Suefuji H, Ohno T, Tsuji H, et al. Multi-institutional retrospective study of mucoepidermoid carcinoma treated with carbon-ion radiotherapy. Cancer Sci. 2017;108:1447-1451 pubmed publisher
    ..Carbon-ion radiotherapy was efficacious and safe for treating mucoepidermoid carcinoma in this multi-institutional retrospective study (registration no. UMIN000024473). We are currently undertaking a prospective multicenter study. ..