ischemic postconditioning


Summary: The application of repeated, brief periods of vascular occlusion at the onset of REPERFUSION to reduce REPERFUSION INJURY that follows a prolonged ischemic event. The techniques are similar to ISCHEMIC PRECONDITIONING but the time of application is after the ischemic event instead of before.

Top Publications

  1. Maslov L, Mrochek A, Barzakh E, Lishmanov A, Gorbunov A, Tsibul nikov S, et al. [Trigger mechanism of adaptive phenomenon of ischemic heart postconditioning]. Ross Fiziol Zh Im I M Sechenova. 2012;98:1053-69 pubmed
    ..It is shown that B-type natriuretic peptide, transforming growth factor-beta1, cardiotrophin-1, urocortin, acetylcholine, insulin and carbon monoxide can mimic postconditioning phenomenon. ..
  2. Costa F, Yamaki V, Teixeira R, Feijó D, Valente A, Carvalho L, et al. Perconditioning combined with postconditioning on kidney ischemia and reperfusion. Acta Cir Bras. 2017;32:599-606 pubmed publisher
    ..There was no additive protection when postconditioning and perconditioning were combined. ..
  3. Zaugg M, Lou P, Lucchinetti E, Gandhi M, Clanachan A. Postconditioning with Intralipid emulsion protects against reperfusion injury in post-infarct remodeled rat hearts by activation of ROS-Akt/Erk signaling. Transl Res. 2017;186:36-51.e2 pubmed publisher
    ..Our data provide a rationale for the clinical evaluation of ILE postconditioning where ILE is administered as a bolus at the onset of reperfusion. ..
  4. Maslov L, Podoksenov A, Khaliulin I. [The phenomenon of ischaemic postconditioning of the heart. Analysis of clinical data]. Angiol Sosud Khir. 2017;23:21-28 pubmed
  5. Wang Y, Li T, Liu Y, Liu B, Hu X, Wang Y, et al. [Effect of the ischemic post-conditioning on the prevention of the cardio-renal damage in patients with acute ST-segment elevation myocardial infarction after primary percutaneous coronary intervention]. Zhonghua Xin Xue Guan Bing Za Zhi. 2017;45:277-282 pubmed publisher
    ..06%(18/128)?p?0.034]??????1???????????????????[7.32%(9/123)?15.63%(20/128)?p?0.040]? ??? stemi???ppci????ipc?????????????????????????1??????????????????????????????????????????????????chictr?icr?15006590?. ..
  6. Wever K, Menting T, Masereeuw R, van der Vliet J, Rongen G, Warlé M. Local and remote ischemic postconditionings have synergistic protective effects on renal ischemia-reperfusion injury. Transplantation. 2012;94:e1-2 pubmed publisher
  7. Seewald M, Coles J, Sigg D, Iaizzo P. Featured Article: Pharmacological postconditioning with delta opioid attenuates myocardial reperfusion injury in isolated porcine hearts. Exp Biol Med (Maywood). 2017;242:986-995 pubmed publisher
    ..Such agents may have a potential role in minimizing reperfusion injury associated with coronary stenting, bypass surgery, myocardial infarction, cardiac transplantation, or with the utilization of heart preservation systems. ..
  8. McCafferty K, Byrne C, Yaqoob M. Renal postconditioning...pause for thought? Correspondence regarding "Protection against renal ischemia-reperfusion injury by ischemic postconditioning". Transplantation. 2013;96:e51-3 pubmed publisher
  9. Gao W, Zhao B, Liu L, Yuan Q, Wu X, Xia Z. Myocardial ischemic post-conditioning protects the lung against myocardial ischemia/reperfusion-induced damage by activating GSK-3?. Acta Cir Bras. 2017;32:376-387 pubmed publisher
    ..Myocardial ischemia reperfusion injury induces acute lung injury by induction of inflammation and cell apoptosis. Ischemic post-conditioning protects the lung from ALI following MIRI by increasing p-GSK-3?. ..

More Information


  1. Fang R, Zhang L, Zhang L, Li W, Li M, Wen K. Sphingosine 1-Phosphate Postconditioning Protects Against Myocardial Ischemia/reperfusion Injury in Rats via Mitochondrial Signaling and Akt-Gsk3? Phosphorylation. Arch Med Res. 2017;48:147-155 pubmed publisher
    ..These results suggest that S1P postconditioning protects against MIRI by regulating mitochondrial signaling and Akt/Gsk3? phosphorylation. ..
  2. Cui C, Lin H, Shi Y, Pan R. Hypoxic postconditioning attenuates apoptosis via inactivation of adenosine A2a receptor through NDRG3-Raf-ERK pathway. Biochem Biophys Res Commun. 2017;491:277-284 pubmed publisher
    ..However, the protective effect of hypoxia postconditioning treatment could be inhibited by adding CGS21680, a selective adenosine A2a receptor agonist (all P values < 0.05). ..
  3. Fong D, Cummings L. Mathematical Modeling of Ischemia-Reperfusion Injury and Postconditioning Therapy. Bull Math Biol. 2017;79:2474-2511 pubmed publisher
  4. Hahn J, Song Y, Kim E, Yu C, Bae J, Chung W, et al. Response to letters regarding article, "Ischemic postconditioning during primary percutaneous coronary intervention: the effects of postconditioning on myocardial reperfusion in patients with ST-segment elevation myocardial infarction (POST) ran. Circulation. 2014;130:e54-5 pubmed publisher
  5. Heusch G, Kleinbongard P, Skyschally A. Myocardial infarction and coronary microvascular obstruction: an intimate, but complicated relationship. Basic Res Cardiol. 2013;108:380 pubmed publisher
  6. Lefer D, Marbán E. Is Cardioprotection Dead?. Circulation. 2017;136:98-109 pubmed publisher
    ..The recognition that cell therapy may be cardioprotective, and not just regenerative, merits further exploration before we abandon the pursuit entirely. ..
  7. Gao Y, Yang H, Chi J, Xu Q, Zhao L, Yang W, et al. Hydrogen Gas Attenuates Myocardial Ischemia Reperfusion Injury Independent of Postconditioning in Rats by Attenuating Endoplasmic Reticulum Stress-Induced Autophagy. Cell Physiol Biochem. 2017;43:1503-1514 pubmed publisher
    ..To study the effect of inhaling hydrogen gas on myocardial ischemic/reperfusion(I/R) injury in rats...
  8. Heusch G. Critical Issues for the Translation of Cardioprotection. Circ Res. 2017;120:1477-1486 pubmed publisher
    ..Future trials must focus on interventions/agents with robust preclinical evidence, have solid phase II dosing and timing data, and recruit patients who have truly a chance to benefit from adjunct cardioprotection. ..
  9. Wang Z, Wang N, Harmouche S, Philip T, Pang X, Bai F, et al. Postconditioning attenuates coronary perivascular and interstitial fibrosis through modulating angiotensin II receptors and angiotensin-converting enzyme 2 after myocardial infarction. J Surg Res. 2017;211:178-190 pubmed publisher
    ..These results suggest that Postcon could be selected as an adjunctive intervention with other existing therapeutic drugs to treat the fibrosis-derived heart failure patients after myocardial infarction. ..