vagus nerve stimulation


Summary: An adjunctive treatment for PARTIAL EPILEPSY and refractory DEPRESSION that delivers electrical impulses to the brain via the VAGUS NERVE. A battery implanted under the skin supplies the energy.

Top Publications

  1. Amarasiri D, Pathmeswaran A, de Silva H, Ranasinha C. Response of the airways and autonomic nervous system to acid perfusion of the esophagus in patients with asthma: a laboratory study. BMC Pulm Med. 2013;13:33 pubmed publisher
    ..Gastro-esophageal reflux disease (GERD) predisposes to airway disease through a vagally-mediated esophago-bronchial reflex. This study investigates this vagal response to esophageal acid perfusion...
  2. Tisi G, Franzini A, Messina G, Savino M, Gambini O. Vagus nerve stimulation therapy in treatment-resistant depression: a series report. Psychiatry Clin Neurosci. 2014;68:606-11 pubmed
    The purpose of this study was to evaluate the efficacy of vagus nerve stimulation (VNS) as a therapeutic option for treatment-resistant depression (TRD), with follow-up periods of 1, 3 and 5 years after VNS surgery...
  3. Inoue T, Abe C, Sung S, Moscalu S, Jankowski J, Huang L, et al. Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through ?7nAChR+ splenocytes. J Clin Invest. 2016;126:1939-52 pubmed publisher
    ..antiinflammatory pathway regulates innate and adaptive immunity, and modulation of this reflex by vagus nerve stimulation (VNS) is effective in various inflammatory disease models, such as rheumatoid arthritis and inflammatory ..
  4. Kawai K. [Vagus nerve stimulation for intractable epilepsy: implantation of vagus nerve stimulator]. No Shinkei Geka. 2008;36:979-89 pubmed
  5. Koopman F, van Maanen M, Vervoordeldonk M, Tak P. Balancing the autonomic nervous system to reduce inflammation in rheumatoid arthritis. J Intern Med. 2017;282:64-75 pubmed publisher
    ..have found that stimulation of the so-called cholinergic anti-inflammatory pathway by efferent electrical vagus nerve stimulation (VNS) or pharmacological activation of the alpha7 subunit of nicotinic acetylcholine receptors (α7nAChR) ..
  6. Jin H, Guo J, Liu J, Lyu B, Foreman R, Yin J, et al. Anti-inflammatory effects and mechanisms of vagal nerve stimulation combined with electroacupuncture in a rodent model of TNBS-induced colitis. Am J Physiol Gastrointest Liver Physiol. 2017;313:G192-G202 pubmed publisher
    ..View this article's corresponding video summary at ..
  7. Liu H, Yang Z, Huang L, Qu W, Hao H, Li L. Heart-rate variability indices as predictors of the response to vagus nerve stimulation in patients with drug-resistant epilepsy. Epilepsia. 2017;58:1015-1022 pubmed publisher
    ..electrocardiography (ECG) for drug-resistant epilepsy and to relate the findings to the outcome of vagus nerve stimulation (VNS) treatment...
  8. Voors A, Ruschitzka F. The year in cardiology: heart failure 2014. Eur Heart J. 2015;36:421-4 pubmed publisher
  9. Edwards C, Kouzani A, Lee K, Ross E. Neurostimulation Devices for the Treatment of Neurologic Disorders. Mayo Clin Proc. 2017;92:1427-1444 pubmed publisher
    ..This review provides an overview of the increasingly common stimulation systems, their clinical indications, and enabling technologies. ..

More Information


  1. Bonaz B, Sinniger V, Pellissier S. Vagus nerve stimulation: a new promising therapeutic tool in inflammatory bowel disease. J Intern Med. 2017;282:46-63 pubmed publisher
    ..tone and plasma TNFα level in patients with CD, and have reported, for the first time, that chronic vagus nerve stimulation has anti-inflammatory properties in a rat model of colitis and in a pilot study performed in seven ..
  2. Giordano F, Zicca A, Barba C, Guerrini R, Genitori L. Vagus nerve stimulation: Surgical technique of implantation and revision and related morbidity. Epilepsia. 2017;58 Suppl 1:85-90 pubmed publisher
    Indications for vagus nerve stimulation (VNS) therapy include focal, multifocal epilepsy, drop attacks (tonic/atonic seizures), Lennox-Gastaut syndrome, tuberous sclerosis complex (TSC)-related multifocal epilepsy, and unsuccessful ..
  3. Buchholz B, Donato M, Perez V, Ivalde F, Hocht C, Buitrago E, et al. Preischemic efferent vagal stimulation increases the size of myocardial infarction in rabbits. Role of the sympathetic nervous system. Int J Cardiol. 2012;155:490-1 pubmed publisher
  4. Schlaepfer T, George M, Mayberg H. WFSBP Guidelines on Brain Stimulation Treatments in Psychiatry. World J Biol Psychiatry. 2010;11:2-18 pubmed publisher
  5. Camm A, Savelieva I. Vagal nerve stimulation in heart failure. Eur Heart J. 2015;36:404-6 pubmed publisher
  6. Sundman E, Olofsson P. Neural control of the immune system. Adv Physiol Educ. 2014;38:135-9 pubmed
    ..production and alleviates experimental shock and autoimmune disease, and recent data have suggested that vagus nerve stimulation can improve symptoms in human rheumatoid arthritis...
  7. Beaumont E, Campbell R, Andresen M, Scofield S, Singh K, Libbus I, et al. Cervical vagus nerve stimulation augments spontaneous discharge in second- and higher-order sensory neurons in the rat nucleus of the solitary tract. Am J Physiol Heart Circ Physiol. 2017;313:H354-H367 pubmed publisher
    b>Vagus nerve stimulation (VNS) currently treats patients with drug-resistant epilepsy, depression, and heart failure...
  8. Yuan W, Williams B. Long-term vagus nerve stimulation for severe refractory depression: a case study with a six-year follow-up. J Neuropsychiatry Clin Neurosci. 2012;24:E50-1 pubmed publisher
  9. Bayasgalan B, Matsuhashi M, Fumuro T, Nohira H, Nakano N, Iida K, et al. We could predict good responders to vagus nerve stimulation: A surrogate marker by slow cortical potential shift. Clin Neurophysiol. 2017;128:1583-1589 pubmed publisher
    We investigated whether vagus nerve stimulation (VNS) induces a positive shift of slow cortical potentials (SCPs) in patients with >50% seizure reduction (responders) but not in non-responders...