cardiac resynchronization therapy


Summary: The restoration of the sequential order of contraction and relaxation of the HEART ATRIA and HEART VENTRICLES by atrio-biventricular pacing.

Top Publications

  1. Sassone B, Bertini M, Beltrami M, Malagù M, Pasanisi G, Kuwornu H, et al. Relation of QRS Duration to Response to Cardiac Resynchronization Therapy in Patients With Left Bundle Branch Block. Am J Cardiol. 2017;119:1803-1808 pubmed publisher
    Left ventricular (LV) dyssynchrony (LVdys) is a necessary condition for successful cardiac resynchronization therapy (CRT)...
  2. Daubert J, Saxon L, Adamson P, Auricchio A, Berger R, Beshai J, et al. 2012 EHRA/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management. Heart Rhythm. 2012;9:1524-76 pubmed publisher
  3. Motonaga K, Dubin A. Cardiac resynchronization therapy for pediatric patients with heart failure and congenital heart disease: a reappraisal of results. Circulation. 2014;129:1879-91 pubmed publisher
  4. Neubauer S, Redwood C. New mechanisms and concepts for cardiac-resynchronization therapy. N Engl J Med. 2014;370:1164-6 pubmed publisher
  5. Janousek J, Kovanda J, Ložek M, Tomek V, Vojtovic P, Gebauer R, et al. Pulmonary Right Ventricular Resynchronization in Congenital Heart Disease: Acute Improvement in Right Ventricular Mechanics and Contraction Efficiency. Circ Cardiovasc Imaging. 2017;10: pubmed publisher
    ..We sought to evaluate changes in RV function after temporary RV cardiac resynchronization therapy. Twenty-five patients aged median 12...
  6. Priori S, Wilde A, Horie M, Cho Y, Behr E, Berul C, et al. Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. Heart Rhythm. 2013;10:e85-108 pubmed publisher
  7. Nassif M, Tang Y, Cleland J, Abraham W, Linde C, Gold M, et al. Precision Medicine for Cardiac Resynchronization: Predicting Quality of Life Benefits for Individual Patients-An Analysis From 5 Clinical Trials. Circ Heart Fail. 2017;10: pubmed publisher
    Clinical trials have established the average benefit of cardiac resynchronization therapy (CRT), but estimating benefit for individual patients remains difficult because of the heterogeneity in treatment response...
  8. Gwag H, Chun K, Hwang J, Park K, On Y, Kim J, et al. Comparison of De Novo versus Upgrade Cardiac Resynchronization Therapy; Focused on the Upgrade for Pacing-Induced Cardiomyopathy. Yonsei Med J. 2017;58:703-709 pubmed publisher
    This study aimed to determine whether upgrade cardiac resynchronization therapy (CRT) shows better outcomes than de novo CRT...
  9. Larue Grondin S, Philippon F, Sarrazin J, Dubois Sénéchal S, Dubois M, Senechal M. Very Late Continued Reverse Remodelling After Cardiac Resynchronization Therapy in Patients With Extreme Left Ventricular Dilatation. Can J Cardiol. 2017;33:831.e1-831.e3 pubmed publisher
    Response to cardiac resynchronization therapy (CRT) varies greatly among patients...

More Information


  1. Winnik S, Elsener C, Seifert B, Starck C, Straub A, Saguner A, et al. "Real world" experience in Cardiac Resynchronization Therapy at a Swiss Tertiary Care Center. Swiss Med Wkly. 2017;147:w14425 pubmed publisher
    ..Our data are consistent with large multicentre trials and indicate that CRT is similarly effective in a real-world setting in Switzerland. ..
  2. McAloon C, Theodoreson M, Hayat S, Osman F. Cardiac resynchronization therapy and its role in the management of heart failure. Br J Hosp Med (Lond). 2017;78:312-319 pubmed publisher
    ..Over the last two decades, cardiac resynchronization therapy has revolutionized the treatment of selected patients who have heart failure...
  3. Rickard J, Marine J. Do smaller hearts live longer? The significance of reverse ventricular remodeling for long-term outcomes with cardiac resynchronization therapy. Heart Rhythm. 2015;12:531-532 pubmed publisher
  4. Brignole M, Auricchio A, Baron Esquivias G, Bordachar P, Boriani G, Breithardt O, et al. 2013 ESC guidelines on cardiac pacing and cardiac resynchronization therapy: the task force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Associa. Europace. 2013;15:1070-118 pubmed publisher
  5. Akerström F, Arias M, Casares Medrano J, Pachon M, Puchol A, Rodríguez Picón B, et al. Biventricular pacing-induced torsade de pointes. J Am Coll Cardiol. 2012;60:e23 pubmed publisher
  6. Brunet Bernard A, Leclercq C, Donal E. Defining patients at-risk of non-response to cardiac resynchronization therapy. Value of rest and exercise echocardiography. Int J Cardiol. 2014;171:279-81 pubmed publisher
  7. Brignole M, Auricchio A, Baron Esquivias G, Bordachar P, Boriani G, Breithardt O, et al. 2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: the Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Associa. Eur Heart J. 2013;34:2281-329 pubmed publisher
  8. Gu M, Jin H, Hua W, Fan X, Ding L, Wang J, et al. Repetitive optimizing left ventricular pacing configurations with quadripolar leads improves response to cardiac resynchronization therapy: A single-center randomized clinical trial. Medicine (Baltimore). 2017;96:e8066 pubmed publisher
    ..left ventricular pacing configurations (LVPCs) with quadripolar leads (QUAD) can improve response to cardiac resynchronization therapy (CRT)...
  9. Kpaeyeh J, Divoky L, Hyer J, Daly D, Maran A, Waring A, et al. Impact of Renal Function on Survival After Cardiac Resynchronization Therapy. Am J Cardiol. 2017;120:262-266 pubmed publisher
    ..b>Cardiac resynchronization therapy (CRT) can potentially improve renal function...
  10. Lam C, Solomon S. The middle child in heart failure: heart failure with mid-range ejection fraction (40-50%). Eur J Heart Fail. 2014;16:1049-55 pubmed publisher
  11. Nauffal V, Zhang Y, Tanawuttiwat T, Blasco Colmenares E, Rickard J, Marine J, et al. Clinical decision tool for CRT-P vs. CRT-D implantation: Findings from PROSE-ICD. PLoS ONE. 2017;12:e0175205 pubmed publisher
    b>Cardiac resynchronization therapy (CRT) devices reduce mortality through pacing-induced cardiac resynchronization and implantable cardioverter defibrillator (ICD) therapy for ventricular arrhythmias (VAs)...
  12. Lam P, Taffet G, Ahmed A, Singh S. Cardiac Resynchronization Therapy in Older Adults with Heart Failure. Heart Fail Clin. 2017;13:581-587 pubmed publisher
    ..The advent of cardiac resynchronization therapy has led to a significant improvement in both survival and symptom management in patients with heart ..
  13. Walkey A, Hogarth D, Lip G. Optimizing atrial fibrillation management: from ICU and beyond. Chest. 2015;148:859-864 pubmed publisher
    ..We describe various strategies for the assessment and long-term management of patients with new-onset AF during critical illness. ..
  14. Han Z, Chen Z, Lan R, Di W, Li X, Yu H, et al. Sex-specific mortality differences in heart failure patients with ischemia receiving cardiac resynchronization therapy. PLoS ONE. 2017;12:e0180513 pubmed publisher
    ..studies have reported prognosis differences between male and female heart failure patients following cardiac resynchronization therapy (CRT)...
  15. Zeitler E, Friedman D, Daubert J, Al Khatib S, Solomon S, Biton Y, et al. Multiple Comorbidities and Response to Cardiac Resynchronization Therapy: MADIT-CRT Long-Term Follow-Up. J Am Coll Cardiol. 2017;69:2369-2379 pubmed publisher
    Data regarding cardiac resynchronization therapy (CRT) in patients with multiple comorbidities are limited...
  16. Allen L, Stevenson L, Grady K, Goldstein N, Matlock D, Arnold R, et al. Decision making in advanced heart failure: a scientific statement from the American Heart Association. Circulation. 2012;125:1928-52 pubmed publisher
  17. Kakizaki R, Nabeta T, Ishii S, Koitabashi T, Itatani K, Inomata T, et al. Cardiac resynchronization therapy reduces left ventricular energy loss. Int J Cardiol. 2016;221:546-8 pubmed publisher
  18. Wilkoff B, Fauchier L, Stiles M, Morillo C, Al Khatib S, Almendral J, et al. 2015 HRS/EHRA/APHRS/SOLAECE expert consensus statement on optimal implantable cardioverter-defibrillator programming and testing. Heart Rhythm. 2016;13:e50-86 pubmed publisher
  19. Topaz G, Haim M, Kusniec J, Kazum S, Goldenberg G, Golovchiner G, et al. Association between Red Cell Distribution Width and Mortality after Cardiac Resynchronization Therapy. Isr Med Assoc J. 2015;17:505-9 pubmed
    b>Cardiac resynchronization therapy (CRT) is a non-pharmacological option for patients with heart failure and interventricular dyssynchrony...
  20. Chen J, Lin K, Chang K, Chou C. The Shortest QRS Duration of an Electrocardiogram Might Be an Optimal Electrocardiographic Predictor for Response to Cardiac Resynchronization Therapy. Int Heart J. 2017;58:530-535 pubmed publisher
    QRS duration has been associated with the response to cardiac resynchronization therapy (CRT). However, the methods for defining QRS duration to predict the outcome of CRT have discrepancies in previous reports...
  21. Baron Esquivias G, Morillo C, Moya Mitjans A, Martínez Alday J, Ruiz Granell R, Lacunza Ruiz J, et al. Dual-Chamber Pacing With Closed Loop Stimulation in Recurrent Reflex Vasovagal Syncope: The SPAIN Study. J Am Coll Cardiol. 2017;70:1720-1728 pubmed publisher
    ..Closed Loop Stimulation for Neuromediated Syncope [SPAIN Study]; NCT01621464). ..
  22. Siontis K, Pantos I, Katritsis D. Comparison of the longevity of implantable cardioverter-defibrillator devices by different manufacturers. Int J Cardiol. 2014;175:380-2 pubmed publisher
  23. Masoudi F, Mi X, Curtis L, Peterson P, Curtis J, Fonarow G, et al. Comparative effectiveness of cardiac resynchronization therapy with an implantable cardioverter-defibrillator versus defibrillator therapy alone: a cohort study. Ann Intern Med. 2014;160:603-11 pubmed publisher
    Trials comparing implantable cardioverter-defibrillator (ICD) therapy with cardiac resynchronization therapy with a defibrillator (CRT-D) are limited to selected patients treated at centers with extensive experience...
  24. Dhesi S, Lockwood E, Sandhu R. Troubleshooting Cardiac Resynchronization Therapy in Nonresponders. Can J Cardiol. 2017;33:1060-1065 pubmed publisher
    ..Despite the advancements in pharmacotherapy, HF-related morbidity and mortality remains high. Cardiac resynchronization therapy (CRT) has been revolutionary in medically refractory, symptomatic HF patients with reduced ejection ..
  25. Moguilevitch M, Rufino M, Leff J, Delphin E. Novel approach for heart failure treatment after liver transplantation. Liver Transpl. 2015;21:1103-4 pubmed publisher
  26. Gu X, Zhu Y, Sun L, Zhang Y, Cao K, Cheng J. Impact of rate control during atrial fibrillation on the proarrhythmic and antiarrhythmic effects of biventricular pacing. Int J Cardiol. 2012;159:162-3 pubmed publisher
  27. McMurray J, Adamopoulos S, Anker S, Auricchio A, Bohm M, Dickstein K, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the . Eur Heart J. 2012;33:1787-847 pubmed publisher
  28. Sundaram V, Sahadevan J, Waldo A, Stukenborg G, Reddy Y, Asirvatham S, et al. Implantable Cardioverter-Defibrillators With Versus Without Resynchronization Therapy in Patients With a QRS Duration >180 ms. J Am Coll Cardiol. 2017;69:2026-2036 pubmed publisher
    More than 20% of Medicare beneficiaries receiving cardiac resynchronization therapy defibrillators (CRT-D) have a very wide (≥180 ms) QRS complex duration (QRSD)...
  29. Kim J, Hwang J, Choi J, Choi H, Kim M, Jung S, et al. Frequency and clinical impact of retained implantable cardioverter defibrillator lead materials in heart transplant recipients. PLoS ONE. 2017;12:e0176925 pubmed publisher
    End-stage heart failure patients with implantable cardioverter-defibrillator (ICD) with/without cardiac resynchronization therapy (CRT-D) often require heart transplantation (HTPL) as a last-resort treatment...
  30. Melczer C, Melczer L, Goják I, Kónyi A, Szabados S, Raposa L, et al. [Analysis of telemetry, on-line and non-telemetry data for characterization of the physical activity of patients with heart failure]. Orv Hetil. 2017;158:1390-1395 pubmed publisher
    ..Orv Hetil. 2017; 158(35): 1390-1395. ..
  31. Dickstein K, Vardas P, Auricchio A, Daubert J, Linde C, McMurray J, et al. 2010 focused update of ESC Guidelines on device therapy in heart failure: an update of the 2008 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure and the 2007 ESC Guidelines for cardiac and resynchronization therapy. D. Eur J Heart Fail. 2010;12:1143-53 pubmed publisher
  32. Leyva F, Zegard A, Acquaye E, Gubran C, Taylor R, Foley P, et al. Outcomes of Cardiac Resynchronization Therapy With or Without Defibrillation in Patients With Nonischemic Cardiomyopathy. J Am Coll Cardiol. 2017;70:1216-1227 pubmed publisher
    Recent studies have cast doubt on the benefit of cardiac resynchronization therapy (CRT) with defibrillation (CRT-D) versus pacing (CRT-P) for patients with nonischemic cardiomyopathy (NICM)...
  33. Yin F, Fan C, Guo Y, Zhu H, Wang Z. The impact of gender difference on clinical and echocardiographic outcomes in patients with heart failure after cardiac resynchronization therapy: A systematic review and meta-analysis. PLoS ONE. 2017;12:e0176248 pubmed publisher
    b>Cardiac resynchronization therapy(CRT) has been recommended as a standard treatment for patients with advanced heart failure...
  34. Mizia Stec K, Wita K, Mizia M, Szwed H, Nowalany Kozielska E, Chrzanowski Ł, et al. Preserved contractile reserve in a dobutamine test for the prediction of a response to resynchronisation therapy in ischaemic and non-ischaemic cardiomyopathy--a multicenter ViaCRT study. Int J Cardiol. 2014;172:476-7 pubmed publisher
  35. Bhatt H, Fischer G. Atrial Fibrillation: Pathophysiology and Therapeutic Options. J Cardiothorac Vasc Anesth. 2015;29:1333-40 pubmed publisher
  36. Vidula H, Kutyifa V, McNitt S, Goldenberg I, Solomon S, Moss A, et al. Long-Term Survival of Patients With Left Bundle Branch Block Who Are Hypo-Responders to Cardiac Resynchronization Therapy. Am J Cardiol. 2017;120:825-830 pubmed publisher
    Guidelines support cardiac resynchronization therapy with a defibrillator (CRT-D) in mild heart failure (HF) patients with left bundle branch block (LBBB)...
  37. Skaf S, Thibault B, Khairy P, O Meara E, Fortier A, Vakulenko H, et al. Impact of Left Ventricular vs Biventricular Pacing on Reverse Remodelling: Insights From the Evaluation of Resynchronization Therapy for Heart Failure (EARTH) Trial. Can J Cardiol. 2017;33:1274-1282 pubmed publisher
    Studies comparing biventricular (BiV) cardiac resynchronization therapy (CRT) and left ventricular (LV) pacing alone have yielded conflicting results...
  38. . Guidelines for Non-Pharmacotherapy of Cardiac Arrhythmias (JCS 2011). Circ J. 2013;77:249-74 pubmed
  39. Santos Díaz A, Valdes Cristerna R, Vallejo E, Hernandez S, Jimenez Angeles L. Automated Classification of Severity in Cardiac Dyssynchrony Merging Clinical Data and Mechanical Descriptors. Comput Math Methods Med. 2017;2017:3087407 pubmed publisher
    b>Cardiac resynchronization therapy (CRT) improves functional classification among patients with left ventricle malfunction and ventricular electric conduction disorders...
  40. Liu K, Hua B, Guo T, Pu L. The assessment of the long-term effects of elective CRT-D of coronary heart disease after PCI. Eur Rev Med Pharmacol Sci. 2017;21:1313-1317 pubmed
    The present study was planned to evaluate the long-term effects of elective cardiac resynchronization therapy devices (CRT-D) of coronary heart disease after percutaneous coronary intervention (PCI)...
  41. Derval N, Duchateau J, Mahida S, Eschalier R, Sacher F, Lumens J, et al. Distinctive Left Ventricular Activations Associated With ECG Pattern in Heart Failure Patients. Circ Arrhythm Electrophysiol. 2017;10: pubmed publisher
    ..and nonspecific intraventricular conduction delay (NICD) display a relatively limited response to cardiac resynchronization therapy. We sought to compare left ventricular (LV) activation patterns in heart failure patients with ..
  42. Priori S, Blomstrom Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J, et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the E. Eur Heart J. 2015;36:2793-2867 pubmed publisher
  43. Alonso P, Sanz J, García Orts A, Reina S, Jimenez S, Osca J, et al. Usefulness of Sodium Bicarbonate for the Prevention of Contrast-Induced Nephropathy in Patients Undergoing Cardiac Resynchronization Therapy. Am J Cardiol. 2017;120:1584-1588 pubmed publisher
    The use of contrast media during cardiac resynchronization therapy (CRT) devices implantation is associated with the risk of contrast-induced nephropathy (CIN)...
  44. Voors A, Ruschitzka F. The year in cardiology: heart failure 2014. Eur Heart J. 2015;36:421-4 pubmed publisher
  45. Reddy V, Miller M, Neuzil P, Søgaard P, Butter C, Seifert M, et al. Cardiac Resynchronization Therapy With Wireless Left Ventricular Endocardial Pacing: The SELECT-LV Study. J Am Coll Cardiol. 2017;69:2119-2129 pubmed publisher
    A total of 30% to 40% of patients with congestive heart failure eligible for cardiac resynchronization therapy (CRT) either do not respond to conventional CRT or remain untreated due to an inability or impediment to coronary sinus (CS) ..
  46. Sardu C, Santamaria M, Funaro S, Sacra C, Barbieri M, Paolisso P, et al. Cardiac electrophysiological alterations and clinical response in cardiac resynchronization therapy with a defibrillator treated patients affected by metabolic syndrome. Medicine (Baltimore). 2017;96:e6558 pubmed publisher
    ..syndrome (MS) is a multifactorial disease that can affect clinical outcomes in patients treated by Cardiac Resynchronization Therapy with a defibrillator (CRT-d).Ninety-one patients received a CRT-d...
  47. Isnard R, Hammoudi N, Legrand L, Pousset F. [Main novelties of the last set of European guidelines for the management of heart failure]. Presse Med. 2017;46:758-765 pubmed publisher
    ..the management of comorbidities including iron deficiency, simplification of the indications for cardiac resynchronization therapy, and finally a growing attention to patient pathways and to the management of hospital discharge...
  48. Cronin E, Jones P, Seth M, Varma N. Right Ventricular Pacing Increases Risk of Appropriate Implantable Cardioverter-Defibrillator Shocks Asymmetrically: An Analysis of the ALTITUDE Database. Circ Arrhythm Electrophysiol. 2017;10: pubmed publisher
    ..We analyzed a large remote monitoring database to assess this question...
  49. Rodriguez Muñoz D, Moya Mur J, Moreno J, Fernandez Golfin C, Franco E, Berlot B, et al. Mitral-Aortic Flow Reversal in Cardiac Resynchronization Therapy: Coupling With Ejection and Impact of Variations in Atrioventricular Delay. Circ Arrhythm Electrophysiol. 2017;10:e004927 pubmed publisher
    ..Forty consecutive patients with cardiac resynchronization therapy underwent intracardiac flow analysis and AVD optimization...
  50. Dickstein K, Vardas P, Auricchio A, Daubert J, Linde C, McMurray J, et al. 2010 Focused Update of ESC Guidelines on device therapy in heart failure: an update of the 2008 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure and the 2007 ESC guidelines for cardiac and resynchronization therapy. D. Eur Heart J. 2010;31:2677-87 pubmed publisher
  51. Russo A, Stainback R, Bailey S, Epstein A, Heidenreich P, Jessup M, et al. ACCF/HRS/AHA/ASE/HFSA/SCAI/SCCT/SCMR 2013 appropriate use criteria for implantable cardioverter-defibrillators and cardiac resynchronization therapy: a report of the American College of Cardiology Foundation appropriate use criteria task force, Heart. J Am Coll Cardiol. 2013;61:1318-68 pubmed publisher
  52. Budts W, Borjesson M, Chessa M, van Buuren F, Trigo Trindade P, Corrado D, et al. Physical activity in adolescents and adults with congenital heart defects: individualized exercise prescription. Eur Heart J. 2013;34:3669-74 pubmed publisher
  53. Ellison K, Sharma P, Trohman R. Advances in cardiac pacing and defibrillation. Expert Rev Cardiovasc Ther. 2017;15:429-440 pubmed publisher
    ..Additional technological evolution promises to make the future of CIEDs exciting. ..