drug chronotherapy


Summary: The adaptation of drug administration to the known variations in biological RHYTHMICITY, such as CIRCADIAN RHYTHMS. The treatment is aimed at supporting normal rhythms, or modifying the timing of therapy to achieve maximal efficacy and minimal adverse effect.

Top Publications

  1. Spies C, Straub R, Cutolo M, Buttgereit F. Circadian rhythms in rheumatology--a glucocorticoid perspective. Arthritis Res Ther. 2014;16 Suppl 2:S3 pubmed publisher
    ..m. can inhibit proinflammatory sequelae of nocturnal inflammation better compared with GC administration in the morning but does not increase the risk of HPA axis insufficiency in RA. ..
  2. Ballesta A, Innominato P, Dallmann R, Rand D, Lévi F. Systems Chronotherapeutics. Pharmacol Rev. 2017;69:161-199 pubmed publisher
  3. Skolnik N, Jaffa F, Kalyani R, Johnson E, Shubrook J. Reducing CV risk in diabetes: An ADA update. J Fam Pract. 2017;66:300-308 pubmed
    ..This Q&A highlights changes to the ADA's 2017 Standards of Care to help you fine-tune your approach to patients who have, or are at risk for, atherosclerotic CV disease. ..