drug therapy


Summary: The use of DRUGS to treat a DISEASE or its symptoms. One example is the use of ANTINEOPLASTIC AGENTS to treat CANCER.

Top Publications

  1. Stolk W, Ten Bosch Q, de Vlas S, Fischer P, Weil G, Goldman A. Modeling the impact and costs of semiannual mass drug administration for accelerated elimination of lymphatic filariasis. PLoS Negl Trop Dis. 2013;7:e1984 pubmed publisher
    ..Semiannual MDA is likely to shorten the time and lower the cost required for LF elimination in countries where it can be implemented. This strategy may improve prospects for global elimination of LF by the target year 2020. ..
  2. Kemper E, Merkus M, Wierenga P, Van Rijn P, Van der Werff D, Lie A Huen L, et al. Towards evidence-based pharmacotherapy in children. Paediatr Anaesth. 2011;21:183-9 pubmed publisher
    ..The goals of this paper are to review the current problems in daily practice and to address the needs for evidence based pharmacotherapy in children. ..
  3. Kim Kjærulff S, Wich L, Kringelum J, Jacobsen U, Kouskoumvekaki I, Audouze K, et al. ChemProt-2.0: visual navigation in a disease chemical biology database. Nucleic Acids Res. 2013;41:D464-9 pubmed publisher
    ..Filtering options were included in order to facilitate and to guide dynamic search of specific queries. ..
  4. Sera L, McPherson M. Pharmacokinetics and pharmacodynamic changes associated with aging and implications for drug therapy. Clin Geriatr Med. 2012;28:273-86 pubmed publisher
    ..Consideration of initial dose adjustment, along with frequent medication reconciliation and analysis of the medication list, are keys to providing optimal pharmaceutical care for elderly patients. ..
  5. Zhao X, Iskar M, Zeller G, Kuhn M, van Noort V, Bork P. Prediction of drug combinations by integrating molecular and pharmacological data. PLoS Comput Biol. 2011;7:e1002323 pubmed publisher
    ..We believe that our proposed approach can help to limit the search space of drug combinations and provide a new way to effectively utilize existing drugs for new purposes. ..
  6. Pulcini C, Bush K, Craig W, Frimodt Møller N, Grayson M, Mouton J, et al. Forgotten antibiotics: an inventory in Europe, the United States, Canada, and Australia. Clin Infect Dis. 2012;54:268-74 pubmed publisher
    ..Fourteen of 33 antibiotics are potentially active against either resistant Gram-positive or Gram-negative bacteria. Urgent measures are then needed to ensure better availability of these antibiotics on a global scale. ..
  7. Gyssens I. Antibiotic policy. Int J Antimicrob Agents. 2011;38 Suppl:11-20 pubmed publisher
    ..The value and support of antibiotic committees, guidelines, ID consultants and/or antimicrobial stewardship teams to prolong the efficacy of available antibiotics will be discussed. ..
  8. Kelly Hope L, Thomas B, Bockarie M, Molyneux D. Lymphatic filariasis in the Democratic Republic of Congo; micro-stratification overlap mapping (MOM) as a prerequisite for control and surveillance. Parasit Vectors. 2011;4:178 pubmed publisher
    ..It is important to analyse these and other factors, such as soil transmitted helminths (STH) and malaria co-endemicity, which will impact on LF elimination...
  9. Bell C, Brener S, Gunraj N, Huo C, Bierman A, Scales D, et al. Association of ICU or hospital admission with unintentional discontinuation of medications for chronic diseases. JAMA. 2011;306:840-7 pubmed publisher
    ..Admission to the ICU was generally associated with an even higher risk of medication discontinuation. ..

More Information


  1. Vercruysse J, Behnke J, Albonico M, Ame S, Angebault C, Bethony J, et al. Assessment of the anthelmintic efficacy of albendazole in school children in seven countries where soil-transmitted helminths are endemic. PLoS Negl Trop Dis. 2011;5:e948 pubmed publisher
    ..The objective of this study, therefore, was to define the efficacy of a single 400 milligram dose of albendazole (ALB) against these three STH using a standardized protocol...
  2. Mercier Darty M, Boutolleau D, Lepeule R, Rodriguez C, Burrel S. Utility of ultra-deep sequencing for detection of varicella-zoster virus antiviral resistance mutations. Antiviral Res. 2018;151:20-23 pubmed publisher
    ..mainly as a result of increasing age, malignancy, immunodeficiency, organ transplantation, or immunosuppressive drug therapy (Cohen, 2013; Koo et al., 2014; Pavlopoulou et al., 2015)...
  3. Buehler S, Madison B, Snyder S, Derzon J, Cornish N, Saubolle M, et al. Effectiveness of Practices To Increase Timeliness of Providing Targeted Therapy for Inpatients with Bloodstream Infections: a Laboratory Medicine Best Practices Systematic Review and Meta-analysis. Clin Microbiol Rev. 2016;29:59-103 pubmed publisher
    ..molecular techniques, polymerase chain reaction (PCR); in situ hybridization, fluorescence; treatment outcome; drug therapy; patient care team; pharmacy service, hospital; hospital information systems; Gram stain; pharmacy service; and ..
  4. Kaur T, Borse V, Sheth S, Sheehan K, Ghosh S, Tupal S, et al. Adenosine A1 Receptor Protects Against Cisplatin Ototoxicity by Suppressing the NOX3/STAT1 Inflammatory Pathway in the Cochlea. J Neurosci. 2016;36:3962-77 pubmed publisher
    ..by suppressing NOX3 and inflammation in the cochlea and could serve as an ideal target for otoprotective drug therapy. Cisplatin is a widely used chemotherapeutic agent for the treatment of solid tumors...
  5. MacKenzie M, Hall R. Pharmacogenomics and pharmacogenetics for the intensive care unit: a narrative review. Can J Anaesth. 2017;64:45-64 pubmed publisher
    Knowledge of how alterations in pharmacogenomics and pharmacogenetics may affect drug therapy in the intensive care unit (ICU) has received little study...
  6. Chiang C, Wang T, Ueng K, Lin T, Yeh H, Chen C, et al. 2015 guidelines of the Taiwan Society of Cardiology and the Taiwan Hypertension Society for the management of hypertension. J Chin Med Assoc. 2015;78:1-47 pubmed publisher
    ..0 gram/day may be harmful. When drug therapy is considered, a strategy called "PROCEED" was suggested (Previous experience, Risk factors, Organ damage, ..
  7. Nutescu E, Wittkowsky A, Burnett A, Merli G, Ansell J, Garcia D. Delivery of optimized inpatient anticoagulation therapy: consensus statement from the anticoagulation forum. Ann Pharmacother. 2013;47:714-24 pubmed publisher
    ..administration, program development/standards, quality improvement/organization and administration, thrombosis/ drug therapy, thrombosis/prevention and control, risk assessment/standards, patient safety/standards, and risk management/..
  8. McNamara D, Goldberger J, Berendsen M, Huffman M. Implantable defibrillators versus medical therapy for cardiac channelopathies. Cochrane Database Syst Rev. 2015;:CD011168 pubmed publisher
    ..Participants must have been randomized to ICD implantation and compared to antiarrhythmic drug therapy or usual care. Two authors independently selected studies for inclusion and extracted the data...
  9. David S, Lancaster T, Stead L, Evins A, Prochaska J. Opioid antagonists for smoking cessation. Cochrane Database Syst Rev. 2013;:CD003086 pubmed publisher
    ..We extracted data in duplicate on the study population, the nature of the drug therapy, the outcome measures, method of randomisation, and completeness of follow-up...
  10. Saito A, Ooki A, Nakamura T, Onodera S, Hayashi K, Hasegawa D, et al. Targeted reversion of induced pluripotent stem cells from patients with human cleidocranial dysplasia improves bone regeneration in a rat calvarial bone defect model. Stem Cell Res Ther. 2018;9:12 pubmed publisher
    ..strategy for osteoporosis, mesenchymal stem cell (MSC) transplantation therapy is performed in addition to drug therapy. However, MSC-based therapy for osteoporosis in CCD patients is difficult due to a reduction in the ability of ..
  11. John E, Katz K, Saxena M, Chokhavatia S, Katz S. Management of Inflammatory Bowel Disease in the Elderly. Curr Treat Options Gastroenterol. 2016;14:285-304 pubmed publisher
    ..No drug therapy is absolutely contraindicated in this population; however, special risk and benefit assessments should be made...
  12. Cong T, Hao D, Wen X, Li X, He G, Jiang X. From pathogenesis of acne vulgaris to anti-acne agents. Arch Dermatol Res. 2019;: pubmed publisher
    ..In addition to drug therapy, diet with no hyperglycemic carbohydrates, no milk and dairy products is also beneficial for treatment of acne.
  13. Kobow K, Blumcke I. Epigenetics in epilepsy. Neurosci Lett. 2018;667:40-46 pubmed publisher
    ..More than 30% of patients with epilepsy have inadequate control of their seizures with drug therapy. Any structural brain lesion can provoke epilepsy...
  14. van Gent R, Metselaar H, Kwekkeboom J. Immunomodulation by hyperimmunoglobulins after solid organ transplantation: Beyond prevention of viral infection. Transplant Rev (Orlando). 2017;31:78-86 pubmed publisher
    ..However, it may still be attractive to combine antiviral drug therapy with hyperimmunoglobulins after SOT, as there is some evidence that hyperimmunoglobulins, similar to high doses ..
  15. Bose P, Verstovsek S. Developmental Therapeutics in Myeloproliferative Neoplasms. Clin Lymphoma Myeloma Leuk. 2017;17S:S43-S52 pubmed publisher
    ..marked efficacy with regard to spleen volume and symptom reduction, have made ruxolitinib the cornerstone of drug therapy in MF...
  16. Michaud L. Managing cancer treatment-induced bone loss and osteoporosis in patients with breast or prostate cancer. Am J Health Syst Pharm. 2010;67:S20-30; quiz S31-3 pubmed publisher
    ..role in screening patients with a history of breast or prostate cancer for bone loss or osteoporosis, making drug therapy recommendations to address the problem, and counseling patients on modifiable risk factors for osteoporosis and ..
  17. Kang M, Das J, Gurunathan S, Park H, Song H, Park C, et al. The cytotoxic effects of dimethyl sulfoxide in mouse preimplantation embryos: a mechanistic study. Theranostics. 2017;7:4735-4752 pubmed publisher
    ..Dimethyl sulfoxide (DMSO) is commonly used as a solvent for water-insoluble substances, a vehicle for drug therapy, and a cryoprotectant for cultured cells...
  18. Grobost V, Khouatra C, Lazor R, Cordier J, Cottin V. Effectiveness of cladribine therapy in patients with pulmonary Langerhans cell histiocytosis. Orphanet J Rare Dis. 2014;9:191 pubmed publisher
    ..Smoking cessation is considered to be critical in management, but has variable effects on outcome. No drug therapy has been validated...
  19. Cai J, Wang L. [Looking back 2018--focused on colorectal cancer]. Zhonghua Wei Chang Wai Ke Za Zhi. 2019;22:9-16 pubmed
    ..to the detection results of tumor-related signaling pathways in patients, cross-guidance selection of targeted drug therapy is also the direction of research...
  20. Mattei R, Dalmarco E, Fröde T. Etanercept administration prevents the inflammatory response induced by carrageenan in the murine air pouch model. Naunyn Schmiedebergs Arch Pharmacol. 2015;388:1247-57 pubmed publisher
    ..The effect of etanercept upon neutrophils apoptosis may indicate the use of this drug therapy in the early stage of rheumatoid arthritis disease.
  21. Robertson L, Ghouri M, Kovács F. Antiplatelet and anticoagulant drugs for prevention of restenosis/reocclusion following peripheral endovascular treatment. Cochrane Database Syst Rev. 2012;:CD002071 pubmed publisher
    ..Interventions were anticoagulant, antiplatelet or other vasoactive drug therapy compared with no treatment, placebo or any other vasoactive drug...