antibiotic prophylaxis

Summary

Summary: Use of antibiotics before, during, or after a diagnostic, therapeutic, or surgical procedure to prevent infectious complications.

Webpages

  1. pediatric terrorism and disaster preparedness: chapter 4. biological terrorism
    www.ahrq.gov/research/pedprep/pedchap4.htm
  2. ahrq webm&m: case & commentary
    webmm.ahrq.gov/case.aspx?caseID=2
  3. nosocomial infections
    www.iph.fgov.be/epidemio/epien/prog7.htm
  4. gbsscreen - newborn nursery at lpch - stanford university school of medicine
    newborns.stanford.edu/GBSscreen.html
  5. special cases to consider - clinical assessment and guidelines | module 1: advanced pain control and sedation | aegd
    ccnmtl.columbia.edu/projects/aegd/mod01_cag_spec.html
  6. service delivery guidelines: intrauterine devices
    www.reproline.jhu.edu/english/6read/6multi/sdg/id.htm
  7. complications from local anesthesia - advanced techniques and local anesthesia | module 1: advanced pain control and sedation | aegd
    ccnmtl.columbia.edu/projects/aegd/mod01_resources.html
  8. search of: cefazolin - list results - clinicaltrials.gov
    clinicaltrials.gov/ct2/results?term=cefazolin
  9. bacterial endocarditis and orthodontics
    www.rcsed.ac.uk/journal/vol45_3/4530002.htm#THE RISK OF ANTI ...
  10. um evidence-based pediatrics web site
    www.med.umich.edu/pediatrics/ebm/topics/cards.htm

Research Grants

  1. EFFECT OF CRANBERRY CONSTITUENTS ON UTI PATHOGENESIS
    Scott J Hultgren; Fiscal Year: 2007
  2. FOCUS
    Jeffrey L Carson; Fiscal Year: 2007
  3. FOCUS Data Coordinating Center
    Michael L Terrin; Fiscal Year: 2007
  4. Immunoprotective monoclonals to B. anthracis spores
    ALISON D O'BRIEN; Fiscal Year: 2003
  5. Peptides surface modification to prevent stent blockage
    Joseph W Leung; Fiscal Year: 2006
  6. Bacteremia from Dental Extraction vs. Oral Hygiene
    Peter B Lockhart; Fiscal Year: 2004
  7. Clinical Trial of Prophylactic Antibiotics for Children*
    Ron Keren; Fiscal Year: 2007
  8. Clinical Trial of Prophylactic Antibiotics for Children with Vesicoureteral Reflu
    Ron Keren; Fiscal Year: 2008
  9. Hemifacial Microsomia: Psychosocial and Other Sequelae
    Martha M Werler; Fiscal Year: 2008
  10. Hemifacial Microsomia: Psychosocial and Other Sequelae
    Martha M Werler; Fiscal Year: 2007

Publications

  1. [Surgical site infection after total knee arthroplasty: a monocenter analysis of 923 first-intention implantations]
    R DeBarge
    Service de Chirurgie Orthopédique et Traumatologique, Centre Albert Trillat, rue Margnolles, 69300 Caluire
    Rev Chir Orthop Reparatrice Appar Mot 93:582-7
  2. Administration of cefazolin prior to skin incision is superior to cefazolin at cord clamping in preventing postcesarean infectious morbidity: a randomized, controlled trial
    Scott A Sullivan
    Department of Obstetrics Gynecology, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Obstet Gynecol 196:455.e1-5
  3. Are routine peritoneal fluid cultures during appendicectomy justified?
    M N Khan
    Department of General Surgery, North Hampshire Hospital, Basingstoke, UK
    Ir J Med Sci 176:37-40
  4. [Antibiotic prophylaxis in surgery: news and controversies]
    Silvano Esposito
    Clinica Malattie Infettive, Seconda Universita degli Studi di Napoli, Italy
    Infez Med 10:131-44
  5. Standardized incidence rates of surgical site infection: a multicenter study in Thailand
    Nongyao Kasatpibal
    Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    Am J Infect Control 33:587-94
  6. [Prophylactic antibiotics in neurosurgery]
    G Iacob
    Universitatea de Medicină şi Farmacie Carol Davila Bucureşti, Facultatea de Medicina, Spitalul Universitar de Urgenţă Bucureşti, Clinica de Neurochirurgie
    Rev Med Chir Soc Med Nat Iasi 111:643-8
  7. Role of perioperative antibiotics in endoscopic skull base surgery
    Seth M Brown
    Department of Otorhinolaryngology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Laryngoscope 117:1528-32
  8. The influence of local instillation of fusidic acid on the development of microbial complications after lung resection
    N Baltayiannis
    Department of Thoracic Surgery, Metaxa Cancer Hospital, Piraeus, Greece
    J Chemother 18:285-92
  9. [A questionnaire survey on the theory of postoperative infection prophylaxis in urology]
    Nagao Shinagawa
    Department of Surgery, Nagoya Midori Municipal Hospital
    Jpn J Antibiot 55:500-13
  10. [Perioperative antibiotic prophylaxis in transperitoneal tumor nephrectomy: does it lower the rate of clinically significant postoperative infections?]
    T Steiner
    Klinik und Poliklinik für Urologie der Friedrich Schiller Universität Jena
    Urologe A 42:34-7

Scientific Experts

Detail Information

Webpages36 found, 30 most recent shown here

  1. pediatric terrorism and disaster preparedness: chapter 4. biological terrorism
    www.ahrq.gov/research/pedprep/pedchap4.htm
  2. ahrq webm&m: case & commentary
    webmm.ahrq.gov/case.aspx?caseID=2
  3. nosocomial infections
    www.iph.fgov.be/epidemio/epien/prog7.htm
  4. gbsscreen - newborn nursery at lpch - stanford university school of medicine
    newborns.stanford.edu/GBSscreen.html
  5. special cases to consider - clinical assessment and guidelines | module 1: advanced pain control and sedation | aegd
    ccnmtl.columbia.edu/projects/aegd/mod01_cag_spec.html
  6. service delivery guidelines: intrauterine devices
    www.reproline.jhu.edu/english/6read/6multi/sdg/id.htm
  7. complications from local anesthesia - advanced techniques and local anesthesia | module 1: advanced pain control and sedation | aegd
    ccnmtl.columbia.edu/projects/aegd/mod01_resources.html
  8. search of: cefazolin - list results - clinicaltrials.gov
    clinicaltrials.gov/ct2/results?term=cefazolin
  9. bacterial endocarditis and orthodontics
    www.rcsed.ac.uk/journal/vol45_3/4530002.htm#THE RISK OF ANTI ...
  10. um evidence-based pediatrics web site
    www.med.umich.edu/pediatrics/ebm/topics/cards.htm
  11. channing laboratory - richard platt, md
    www.channing.harvard.edu/platt.htm
  12. bacteroides fragilis
    lib.bioinfo.pl/meid:39151
  13. antrhax - news & journal articles - center for the study of bioterrorism - saint louis university,school of public health
    bioterrorism.slu.edu/anthrax/news.htm
  14. publication: antibiotic prophylaxis: update on common clinical uses
    www.fred.psu.edu/ds/retrieve/fred/publication/8379488
  15. streptococcal infections
    lib.bioinfo.pl/meid:17697
  16. urinary tract infection - children - overview
    www.umm.edu/ency/article/000505.htm
  17. qut eprints
    eprints.qut.edu.au/archive/00005696/
  18. dental care for chronically ill
    buchta.lib.bioinfo.pl/meid:120215
  19. resources | aegd
    ccnmtl.columbia.edu/projects/aegd/resources.html
  20. a randomized controlled trial on antibiotic prophylaxis in children with vesico-ureteral reflux - full text view - clinicaltrials.gov
    clinicaltrials.gov/ct2/show/NCT00382343
  21. dennis e. niewoehner, md - med - dom - pulmonary allergy sleep med, university of minnesota
    www.med.umn.edu/pacc/faculty/niewoehner/home.html
  22. colonoscopy clinical resources
    cchs-dl.slis.ua.edu/clinical/gastroenterology/procedures/col ...
  23. the section of epidemiology, anthrax information
    www.epi.hss.state.ak.us/bt/anthrax/anthrax.stm
  24. cidrap >> anthrax decontamination workers should get vaccine or antibiotics, cdc says
    www.cidrap.umn.edu/cidrap/content/bt/anthrax/news/deconwork. ...
  25. gillian sanders's publications - sprie
    sprie.stanford.edu/people/publications/gilliandsanders
  26. the dave project - gastroenterology - atlas of endoscopy
    dave1.mgh.harvard.edu/SearchResults.cfm?criteria=Anna Ruther ...
  27. ada.org: a-z topics: antibiotic prophylaxis
    www.ada.org/prof/resources/topics/antibiotic.asp
  28. cdc - epidemiologic responses to anthrax outbreaks: a review of field investigations, 1950–2001
    www.cdc.gov/ncidod/eid/vol8no10/02-0223.htm
  29. gillian sanders's publications - fce
    ef.stanford.edu/people/publications/gilliandsanders

Research Grants22

  1. EFFECT OF CRANBERRY CONSTITUENTS ON UTI PATHOGENESIS
    Scott J Hultgren; Fiscal Year: 2007
    ..Because of the rise in antibiotic-resistant bacteria and the deleterious effects of long-term antibiotic prophylaxis, alternative therapies for UTIs are needed...
  2. FOCUS
    Jeffrey L Carson; Fiscal Year: 2007
    ..wrong patient, mislabeling of samples for type and cross match, use of whole blood instead of packed red cells), failure to use thromboembolism prophylaxis, incorrect antibiotic prophylaxis, wrong site surgery and femoral shaft fracture.
  3. FOCUS Data Coordinating Center
    Michael L Terrin; Fiscal Year: 2007
    ..use of whole blood instead of packed red cells), failure to use thromboembolism prophylaxis, incorrect antibiotic prophylaxis, wrong site surgery, and femoral shaft fracture. ..
  4. Immunoprotective monoclonals to B. anthracis spores
    ALISON D O'BRIEN; Fiscal Year: 2003
    ..A remaining health concern is that the people who received antibiotic prophylaxis may still present with inhalation anthrax after conclusion of their therapy as dormant viable spores ..
  5. Peptides surface modification to prevent stent blockage
    Joseph W Leung; Fiscal Year: 2006
    ..including use of different plastic materials, changing stent designs, biocide impregnation and systemic antibiotic prophylaxis. However, none of these methods have produced significant clinical benefits...
  6. Bacteremia from Dental Extraction vs. Oral Hygiene
    Peter B Lockhart; Fiscal Year: 2004
    DESCRIPTION: (provided by applicant): The use of antibiotic prophylaxis to prevent distant site infections (DSI) from oral pathogens remains a controversial issue in clinical practice...
  7. Clinical Trial of Prophylactic Antibiotics for Children*
    Ron Keren; Fiscal Year: 2007
    ..We will also determine whether antibiotic prophylaxis increases the rate of gastrointestinal (Gl) colonization with antibiotic resistant E...
  8. Clinical Trial of Prophylactic Antibiotics for Children with Vesicoureteral Reflu
    Ron Keren; Fiscal Year: 2008
    ..We will also determine whether antibiotic prophylaxis increases the rate of gastrointestinal (Gl) colonization with antibiotic resistant E...
  9. Hemifacial Microsomia: Psychosocial and Other Sequelae
    Martha M Werler; Fiscal Year: 2008
    ..g., orthognathic), treatments (e.g., antibiotic prophylaxis), interventions (e.g., hearing aids), and other speciality consultations...
  10. Hemifacial Microsomia: Psychosocial and Other Sequelae
    Martha M Werler; Fiscal Year: 2007
    ..g., orthognathic), treatments (e.g., antibiotic prophylaxis), interventions (e.g., hearing aids), and other speciality consultations...
  11. Targeting protein synthesis in AML
    ARTHUR FRANKEL; Fiscal Year: 2005
    ..binding and inducing cytokine release from patient monocytes have occurred, necessitating steroid and antibiotic prophylaxis. Further, some patients failed to show leukemic cytoreductions...
  12. Reservoirs of Antibiotic Resistance--Bioinformatics
    Michael Feldgarden; Fiscal Year: 2006
    ..tools and the research activities that they facilitate will have applications in the management of antibiotic prophylaxis and therapy in human disease, animal husbandry and horticulture and in management of genetically modified ..
  13. Reservoirs of Antibiotic Resistance--Bioinformatics
    KARIN U TRAVERS; Fiscal Year: 2002
    ..tools and the research activities that they facilitate will have applications in the management of antibiotic prophylaxis and therapy in human disease, animal husbandry and horticulture and in management of genetically modified ..
  14. Primary Vesicoureteral Reflux in Children
    Tej K Mattoo; Fiscal Year: 2007
    ..Despite the widespread use of antibiotic prophylaxis in children with VUR, there are no placebo-controlled studies demonstrating its clinical benefit in ..
  15. Primary Vesicoureteral Reflux in Children
    Tej K Mattoo; Fiscal Year: 2008
    ..Despite the widespread use of antibiotic prophylaxis in children with VUR, there are no placebo-controlled studies demonstrating its clinical benefit in ..
  16. Virulence regulation in group B Streptococcus
    Michael R Wessels; Fiscal Year: 2008
    DESCRIPTION (provided by applicant): Despite progress in maternal prenatal screening and peripartum antibiotic prophylaxis, group B Streptococcus (Streptococcus agalactiae or GBS) infection remains a leading cause of neonatal sepsis and ..
  17. Virulence regulation in group B Streptococcus
    Michael R Wessels; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Despite progress in maternal prenatal screening and peripartum antibiotic prophylaxis, group B Streptococcus (Streptococcus agalactiae or GBS) infection remains a leading cause of neonatal sepsis and ..
  18. CLINICAL STUDY OF VESICOURETERAL REFLUX IN CHILDREN
    Myra A Carpenter; Fiscal Year: 2008
    ..Candidate interventions are open surgery, endoscopic surgery, or antibiotic prophylaxis. We propose a randomized, placebo-controlled clinical trial of prophlaxic [sic] antibiotic therapy to ..
  19. CLINICAL STUDY OF VESICOURETERAL REFLUX IN CHILDREN
    Myra A Carpenter; Fiscal Year: 2007
    ..Candidate interventions are open surgery, endoscopic surgery, or antibiotic prophylaxis. We propose a randomized, placebo-controlled clinical trial of prophlaxic [sic] antibiotic therapy to ..
  20. POET Study: A Randomized Multi-institutional Clinical Trial of Girls with Reflux
    Saul P Greenfield; Fiscal Year: 2008
    ..While long term antibiotic prophylaxis works well in preventing urinary infection, it has been proposed that it may not be necessary in this ..
  21. POET Study: A Randomized Multi-institutional Clinical T*
    Saul P Greenfield; Fiscal Year: 2007
    ..While long term antibiotic prophylaxis works well in preventing urinary infection, it has been proposed that it may not be necessary in this ..
  22. CONSEQUENCES OF GROUP B STREPTOCOCCAL PROPHYLAXIS
    Anushua Sinha; Fiscal Year: 2004
    ..The research builds on Dr. Sinha's NIAID-funded work to investigate the impact of maternal antibiotic prophylaxis against neonatal group B streptococcus on non-GBS infectious outcomes of both infants and mothers...

Publications62

  1. [Surgical site infection after total knee arthroplasty: a monocenter analysis of 923 first-intention implantations]
    R DeBarge
    Service de Chirurgie Orthopédique et Traumatologique, Centre Albert Trillat, rue Margnolles, 69300 Caluire
    Rev Chir Orthop Reparatrice Appar Mot 93:582-7
    ..Age and body mass index did not differ between patients with and without surgical site infection. CONCLUSION: The analysis of our series demonstrated the difficulties in conducting long-term surveillance...
  2. Administration of cefazolin prior to skin incision is superior to cefazolin at cord clamping in preventing postcesarean infectious morbidity: a randomized, controlled trial
    Scott A Sullivan
    Department of Obstetrics Gynecology, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Obstet Gynecol 196:455.e1-5
    ..This dosing did not result in increased neonatal septic workups or complications...
  3. Are routine peritoneal fluid cultures during appendicectomy justified?
    M N Khan
    Department of General Surgery, North Hampshire Hospital, Basingstoke, UK
    Ir J Med Sci 176:37-40
    ..7%) were the recorded complications in group II. Antibiotics were modified in 3 out of 109 patients. CONCLUSION: Intra-operative peritoneal cultures during appendicectomy do not significantly contribute towards patient management...
  4. [Antibiotic prophylaxis in surgery: news and controversies]
    Silvano Esposito
    Clinica Malattie Infettive, Seconda Universita degli Studi di Napoli, Italy
    Infez Med 10:131-44
    ..adeguate for the situation in question: evidence from several sources would extend the advisability of antibiotic prophylaxis to other clean surgeries; the current classification of surgical procedures does not consider the "..
  5. Standardized incidence rates of surgical site infection: a multicenter study in Thailand
    Nongyao Kasatpibal
    Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    Am J Infect Control 33:587-94
    ..of this study was to estimate the incidence of SSI in 9 hospitals, together with patterns of surgical antibiotic prophylaxis, risk factors for SSI, and common causative pathogens...
  6. [Prophylactic antibiotics in neurosurgery]
    G Iacob
    Universitatea de Medicină şi Farmacie Carol Davila Bucureşti, Facultatea de Medicina, Spitalul Universitar de Urgenţă Bucureşti, Clinica de Neurochirurgie
    Rev Med Chir Soc Med Nat Iasi 111:643-8
    ..Clinical studies emphasized that the most important factors influencing the choice of antibiotic prophylaxis in neurosurgery is the patient's immune status, virulence of the pathogens and the type of surgery ("..
  7. Role of perioperative antibiotics in endoscopic skull base surgery
    Seth M Brown
    Department of Otorhinolaryngology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Laryngoscope 117:1528-32
    ..CONCLUSIONS: Despite direct contamination of the intracranial cavity during endoscopic, endonasal skull base surgery, the risk of CNS infections is low. Limited use of a single perioperative antibiotic may be sufficient prophylaxis...
  8. The influence of local instillation of fusidic acid on the development of microbial complications after lung resection
    N Baltayiannis
    Department of Thoracic Surgery, Metaxa Cancer Hospital, Piraeus, Greece
    J Chemother 18:285-92
    ..838; P <0.001, respectively). These results indicate that local instillation of fusidic acid in the pleural space prior to lung resection seems effective in reducing the rate of septic complications as well as of wound infections...
  9. [A questionnaire survey on the theory of postoperative infection prophylaxis in urology]
    Nagao Shinagawa
    Department of Surgery, Nagoya Midori Municipal Hospital
    Jpn J Antibiot 55:500-13
    ..The most commonly used agent for clean operations are cefazolin (CEZ), followed by cefotiam (CTM) and piperacillin (PIPC), in this order. For clean-contaminated operations, the most commonly used agent is CTM, followed by PIPC and CEZ...
  10. [Perioperative antibiotic prophylaxis in transperitoneal tumor nephrectomy: does it lower the rate of clinically significant postoperative infections?]
    T Steiner
    Klinik und Poliklinik für Urologie der Friedrich Schiller Universität Jena
    Urologe A 42:34-7
    ..prospective randomized study was designed to determine the efficacy of single-shot perioperative antibiotic prophylaxis with 1 g ceftriaxone i.v. in transperitoneal tumor nephrectomy...
  11. Abdominal surgical site infections: incidence and risk factors at an Iranian teaching hospital
    Seyd Mansour Razavi
    Community Medicine Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    BMC Surg 5:2
    ....
  12. Vancomycin versus cefazolin prophylaxis for cerebrospinal shunt placement in a hospital with a high prevalence of meticillin-resistant Staphylococcus aureus
    E Tacconelli
    Department of Infectious Diseases, Catholic University, Rome, Italy
    J Hosp Infect 69:337-44
    ..02). Our data suggest that use of vancomycin as prophylactic agent for cerebrospinal shunt placement reduces the rate of shunt infections in the context of high prevalence of MRSA...
  13. Perioperative antibiotic prophylaxis: a critical review
    Fausto de Lalla
    Department of Infectious Diseases, Ospedale S Bortolo, Vicenza, Italy
    Surg Infect (Larchmt) 7:S37-9
    ..CONCLUSION: Antibiotic prophylaxis is generally overprescribed (i.e., given for too long). Short-duration prophylaxis is effective and safe.
  14. Risk of Clostridium difficile infection after perioperative antibacterial prophylaxis before and during an outbreak of infection due to a hypervirulent strain
    Alex Carignan
    Department of Microbiology and Infectious Diseases, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada
    Clin Infect Dis 46:1838-43
    ..In situations in which the only purpose of PAP is to prevent infrequent and relatively benign infections, the risks may outweigh the benefits in some elderly patients...
  15. Selective antibiotic use to prevent postoperative wound infection after external dacryocystorhinostomy
    Bulent Yazici
    Lions Eye Institute, Department of Opthalmology, Albany Medical College, Albany, New York 12208, USA
    Ophthal Plast Reconstr Surg 18:331-5; discussion 335
    PURPOSE: The use of systemic antibiotic prophylaxis in lacrimal drainage surgery is controversial...
  16. The Society of Thoracic Surgeons Practice Guideline Series: Antibiotic Prophylaxis in Cardiac Surgery, Part I: Duration
    Fred H Edwards
    Division of Cardiothoracic Surgery, University of Florida, Jacksonville, Florida 32209, USA
    Ann Thorac Surg 81:397-404
  17. Amoxicillin/clavulanic acid versus cefotaxime for antimicrobial prophylaxis in abdominal surgery: a randomized trial
    F Tonelli
    Dipartimento di Fisiopatologia Clinica, Università degli Studi di Firenze, Italy
    J Chemother 14:366-72
    ..Its use in surgical prophylaxis may help decrease the cost of treatment and reduce the risk of resistance to antibiotics and superinfections...
  18. [Appropriate antibiotic prophylaxis and treatment in surgery--comparison of concepts in North America and Japan]
    Yoshio Takesue
    Department of Surgery, Programs for Applied Biomedicine, Hiroshima University, Hiroshima, Japan
    Nippon Geka Gakkai Zasshi 105:709-15
    ..Careful application of these concepts should allow surgeons to use more optimal dosing regimens in Japan...
  19. Infective complications according to duration of antibiotic treatment in acute abdomen
    Ana L M Gleisner
    General Surgery Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil
    Int J Infect Dis 8:155-62
    ..CONCLUSIONS: Shorter courses of antibiotic therapy based on the degree of contamination/infection seem to be safe. A prospective study should confirm this hypothesis...
  20. Prophylactic antibiotic use in oral surgery--a review of current concepts
    Ephraim Rikhotso
    Division of Maxillofacial Surgery, Baragwanath Hospital, University of the Witwatersrand, Johannesburg
    SADJ 57:408-13
  21. Single-dose and multi-dose clindamycin therapy fails to demonstrate efficacy in preventing infectious and inflammatory complications in third molar surgery
    T Kaczmarzyk
    Department of Oral Surgery, The Medical College of the Jagiellonian University, ul Montelupich 4, 31 155 Krakow, Poland
    Int J Oral Maxillofac Surg 36:417-22
    ..Clindamycin applied in a single preoperative dose of 600 mg with or without subsequent 5-day therapy does not demonstrate efficacy in prophylaxis for postoperative inflammatory complications after third molar surgery...
  22. Usage of prophylactic antibiotics in uncomplicated gynecologic abdominal surgery in Siriraj hospital
    Dittakarn Boriboonhirunsarn
    Department of Obstetrics and Gynecology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    J Med Assoc Thai 90:1068-73
    ..The rate of postoperative infection between control and study groups, as well as between single and other antibiotic prophylaxis were similar...
  23. Influence of broad-spectrum antibiotic prophylaxis on intracranial pressure monitor infections and subsequent infectious complications in head-injured patients
    Addison K May
    Division of Trauma and Surgical Critical Care, Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Surg Infect (Larchmt) 7:409-17
    BACKGROUND: The benefit of antibiotic prophylaxis for intracranial pressure (ICP) monitors remains controversial, and clinical practice varies widely...
  24. Assessment of a protocol for prophylactic antibiotics to prevent perioperative infection in urological surgery: a preliminary study
    Sojun Kanamaru
    Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Int J Urol 11:355-63
    ..Thus, our protocol of prophylactic antibiotic therapy would be recommended as an appropriate method for preventing perioperative infection in urological surgery...
  25. Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial
    Orjan Friberg
    Department of Cardiothoracic Surgery, Orebro University Hospital, Orebro, Sweden
    Ann Thorac Surg 79:153-61; discussion 161-2
    ..CONCLUSIONS: Local collagen-gentamicin reduced the risk for postoperative sternal wound infections. Further studies are warranted to confirm these results, particularly with regard to deep infections...
  26. Surveillance of post-operative infections and management of antibiotic surgical prophylaxis in an Italian region
    S Esposito
    Dipartimento di Malattie Infettive, Seconda Università di Napoli, Italy
    J Chemother 16:160-5
    ..length of pre- and post-operative hospitalization, type of surgery, intervention duration, possible antibiotic prophylaxis and onset of post-surgical infections also monitored by post-discharge ambulatory controls...
  27. Ertapenem versus cefotetan prophylaxis in elective colorectal surgery
    Kamal M F Itani
    Veterans Affairs Boston Healthcare System and Boston University Medical School, Boston, MA 02132, USA
    N Engl J Med 355:2640-51
    ..METHODS: In this randomized, double-blind trial, we assessed the efficacy and safety of antibiotic prophylaxis with ertapenem, as compared with cefotetan, in patients undergoing elective colorectal surgery...
  28. Quality improvement of surgical prophylaxis in Dutch hospitals: evaluation of a multi-site intervention by time series analysis
    Marjo E E Van Kasteren
    Department of Internal Medicine, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    J Antimicrob Chemother 56:1094-102
    ..4% (95% CI: 4.3-6.5) and 4.6% (95% CI: 3.6-5.4), respectively. CONCLUSIONS: The intervention led to improved quality of surgical prophylaxis and to reduced antibiotic use and costs without impairment of patient outcome...
  29. Role of topical antibiotics in hip surgery. A prospective randomised study
    S Kamath
    Orthopaedics, Leighton Hospital, Crewe, CW1 4QJ, UK
    Injury 36:783-7
    ..However, this was not statistically significant to recommend its use in routine practice. A larger study should provide useful information on the role of topical antibiotic and its effect on postoperative wound infection...
  30. Prophylaxis versus pre-emptive treatment for infective and inflammatory complications of surgical third molar removal: a randomized, double-blind, placebo-controlled, clinical trial with sustained release amoxicillin/clavulanic acid (1000/62.5 mg)
    J M Lacasa
    Service of Internal Medicine, Hospital Mútua de Terrassa, University of Barcelona, Barcelona, Spain
    Int J Oral Maxillofac Surg 36:321-7
    ..Prophylaxis was beneficial in simpler procedures and may be indicated in cases where ostectomy is not performed...
  31. Risk factors for surgical-site infections in head and neck cancer surgery
    Carlos Jorge Lotfi
    Infectious Diseases Service, Hospital do Câncer A C Camargo, São Paulo, Brazil
    Otolaryngol Head Neck Surg 138:74-80
    ..surgery were those with cancer at advanced stages, those who were smokers, those presenting comorbidities, those who needed major reconstruction of the surgical wound, or those who were submitted to inadequate antibiotic prophylaxis.
  32. A prospective placebo-controlled double-blind trial of antibiotic prophylaxis in intraoral bone grafting procedures: a pilot study
    Jerome A H Lindeboom
    Department of Oral and Maxillofacial Surgery, Academic Medical Center and Academic Center for Dentistry, University of Amsterdam, The Netherlands
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:669-72
    ..of a single-dose preoperative prophylactic of the penicillin pheneticillin compared with placebo in the antibiotic prophylaxis of surgical wound infections in intra-oral bone grafting procedures...
  33. Risk factors for neurosurgical site infections after craniotomy: a critical reappraisal of antibiotic prophylaxis on 4,578 patients
    A M Korinek
    Neuroanaesthesia Unit, Department of Anaesthesiology, Pitié Salpêtrière Hospital, University of Paris VI, Paris, France
    Br J Neurosurg 19:155-62
    ..of this study was to evaluate incidence and risk factors of postoperative infections, with emphasis on antibiotic prophylaxis, in a series of 4578 craniotomies...
  34. Reduction in surgical antibiotic prophylaxis expenditure and the rate of surgical site infection by means of a protocol that controls the use of prophylaxis
    Marisa I Gomez
    Sanatorio Adventista del Plata, Facultad de Ciencias de la Salud de la Universidad Adventista del Plata, Libertador San Martín, Entre Ríos, Argentina
    Infect Control Hosp Epidemiol 27:1358-65
    ..protocol with an automatic stop of antimicrobial prophylaxis to improve hospital compliance with surgical antibiotic prophylaxis guidelines...
  35. Preventing postoperative Staphylococcus infections: an update
    Matthew Grady
    Department of Surgery, University of Iowa College of Medicine, and Veterans Affairs Medical Center, Iowa City, IA, USA
    Surg Technol Int 11:57-60
    ..Mupirocin, a topical antibiotic effective against Gram-positive organisms, was proved to be effective in reducing the rates of nasal colonization of S. aureus and decreased postoperative nosocomial infections due to S. aureus...
  36. Post-operative infection following hand surgery. Guidelines for antibiotic use
    A J Platt
    Department of Plastic Surgery, Northern General Hospital, Sheffield, UK
    J Hand Surg Br 20:685-90
    ..002). A postal questionnaire of members of the British Society for Surgery of the Hand revealed a wide variation in antibiotic usage. Guidelines for antibiotic use in patients undergoing hand surgery are presented...
  37. Recovery of the susceptibility of isolated bacterium achieved by giving long-established antibiotics as prophylaxis against postoperative infections
    Shinya Kusachi
    Third Department of Surgery, Toho University School of Medicine, 2-17-6 Ohashi, Meguro-ku, Tokyo 153-8515, Japan
    Surg Today 34:725-31
    ....
  38. Bacteria of preoperative urinary tract infections contaminate the surgical fields and develop surgical site infections in urological operations
    Ryoichi Hamasuna
    Department of Urology, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Int J Urol 11:941-7
    ..CONCLUSIONS: Preoperative UTI was the most important risk factor for SSI following urological operations. It is most likely that the bacteria in the urine contaminated the surgical fields and the AMP resistant strains produced SSI...
  39. Antibiotic prophylaxis in colorectal surgery
    Francesca Rovera
    Department of Surgical Sciences, University of Insubria, Azienda Ospedaliero Universitaria, Fondazione Macchi, Varese, Italy
    Expert Rev Anti Infect Ther 3:787-95
    ..It is reported that without antibiotic prophylaxis, wound infection after colorectal surgery develops in approximately 40% of patients...
  40. Factors associated with postoperative infection
    J D Scott
    Clinical Pharmacokinetics Laboratory, Millard Fillmore Hospital, Buffalo, New York, USA
    Infect Control Hosp Epidemiol 22:347-51
    ..Interestingly, albumin and age were significantly associated with death within 28 days, in addition to early infection, showing the predictive association between these factors and early death...
  41. Antimicrobial prophylaxis in the surgical patient
    Harrison G Weed
    Division of General Internal Medicine, The Ohio State University College of Medicine, 4510 UHC Cramblett Hall, 456 West 10th Avenue, Columbus, OH 43210, USA
    Med Clin North Am 87:59-75
    ..Although we do not have either the randomized, controlled trials or the detailed, patient-specific information to estimate this balance precisely, there are general guidelines to help the clinician choose treatment for most patients...
  42. The practice of perioperative antibiotic prophylaxis in eight German hospitals
    M Dettenkofer
    Institute of Environmental Medicine and Hospital Epidemiology, Freiburg University Hospital, Germany
    Infection 30:164-7
    ..Although there is consensus in the international literature on the benefits of using perioperative antibiotic prophylaxis (PAP), there is still considerable scope for improving its use in many hospitals...
  43. Infectious complications and antibiotic use in dermatologic surgery
    Eva A Hurst
    UCSF Dermatologic Surgery and Laser Center, San Francisco, CA 94115, USA
    Semin Cutan Med Surg 26:47-53
    ..In addition, recommendations surrounding endocarditis and prosthetic joint infection prophylaxis are presented as they apply to dermatologic surgery...
  44. Prevalence and predictors of surgical site infection in Tbilisi, Republic of Georgia
    S Brown
    Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    J Hosp Infect 66:160-6
    ..In a separate model, NNIS risk index was highly predictive of SSI. Antibiotic prophylaxis was rare (29.5% of operations), while postoperative antibiotic use was common...
  45. Intranasal mupirocin to prevent postoperative infections
    Christof von Eiff
    N Engl J Med 347:1207-8; author reply 1207-8
  46. Mupirocin to prevent S. aureus infections
    Barry M Farr
    N Engl J Med 346:1905-6
  47. Five day antibiotic prophylaxis for major lower limb amputation reduces wound infection rates and the length of in-hospital stay
    U Sadat
    Cambridge Vascular Unit, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Eur J Vasc Endovasc Surg 35:75-8
    ..77.5% vs. 55% P=0.033). CONCLUSIONS: This data supports the use of a prolonged 5-day course of combined antibiotics after major lower limb amputation. This appears to reduce stump infection rates leading to shorter in-hospital stay...
  48. A randomized, double-blind, placebo-controlled trial to determine effectiveness of antibiotic prophylaxis for tension-free mesh herniorrhaphy
    Anthony R Perez
    Department of Surgery, University of the Philippines College of Medicine and Philippine General Hospital, Manila, Philippines
    J Am Coll Surg 200:393-7; discussion 397-8
    ..Our results do not support use of antibiotic prophylaxis for tension-free mesh herniorrhaphy.
  49. Prophylactic antibiotics given within 24 hours of surgery, compared with antibiotics given for 72 hours perioperatively, increased the rate of methicillin-resistant Staphylococcus aureus isolated from surgical site infections
    Shinya Kusachi
    Third Department of Surgery, Toho University Ohashi Medical Center Hospital, 2 17 6 Ohashi, Meguro ku, Tokyo, Japan
    J Infect Chemother 14:44-50
    ..aureus (MSSA) were both significantly higher in period B patients (P < 0.005). We concluded that the administration of prophylactic antibiotics within 24 h of surgery increased the rate of isolation of MRSA...
  50. Comparison of routine prophylaxis with vancomycin or cefazolin for femoral neck fracture surgery: microbiological and clinical outcomes
    Jacques Merrer
    Unité de Lutte Contre les Infections Nosocomiales, Hôpital de Poissy St Germain en Laye, Poissy, France
    Infect Control Hosp Epidemiol 27:1366-71
    OBJECTIVE: To assess the impact of antibiotic prophylaxis on the emergence of vancomycin-resistant strains of Enterococcus faecium, Enterococcus faecalis, and Staphylococcus aureus and the incidence of surgical site infection (SSI) after ..
  51. Prospective randomized comparison of single-dose versus 1-day cefazolin for prophylaxis in gynecologic surgery
    Her-Young Su
    Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Acta Obstet Gynecol Scand 84:384-9
    ..Shortening the duration of antibiotics prophylaxis also reduced medical costs and microorganism resistance...
  52. Antimicrobial prophylaxis in laparotomic gynecologic surgery: a prospective randomized study comparing amoxicillin-clavulanic acid with cefazolin
    G Cormio
    Sezione di Ginecologia A, Dipartimento di Scienze Chirurgiche Generali e Specialistiche, Università degli Studi di Bari, Italy
    J Chemother 14:618-22
    ..It is concluded that ultra-short term prophylaxis with both amoxicillin-clavulanic acid and cefazolin is safe and effective in elective laparotomic gynecologic surgery...
  53. Cefazolin versus cefazolin plus metronidazole for antibiotic prophylaxis at cesarean section
    Norman L Meyer
    Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN 38103 2896, USA
    South Med J 96:992-5
    ..0064 versus P = 0.014) compared with cefazolin alone. The estimated antibiotic prophylaxis cost per person was less with cefazolin and metronidazole than with cefazolin alone (9...
  54. A pilot study to determine the feasibility of continuous cefazolin infusion
    Todd Waltrip
    Price Institute of Surgical Research, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Surg Infect (Larchmt) 3:5-9
    ....
  55. End-of-procedure cefazolin concentrations after administration for prevention of surgical-site infection
    Erin Koopman
    Saint Mary s Hospital, Mayo Clinic, Rochester, MN, USA
    Am J Health Syst Pharm 64:1927-34
    ..CONCLUSION: Noncompliance with antimicrobial prophylaxis guidelines was associated with low end-of-procedure antibiotic levels. Compliance with guidelines did not guarantee adequate levels...
  56. Elective intestinal operations in infants and children without mechanical bowel preparation: a pilot study
    Charles M Leys
    Department of Surgery, Vanderbilt Children's Hospital, Vanderbilt University Medical Center, Nashville, TN 37203, USA
    J Pediatr Surg 40:978-81; discussion 982
    ..These findings warrant a large, prospective, randomized clinical trial to validate our findings and to investigate further the necessity of MBP in the pediatric population...
  57. Successful control program to implement the appropriate antibiotic prophylaxis for Cesarean section
    Silvia Nunes Szente Fonseca
    Department of Infection Control, Ribeirão Preto, SP, Brazil
    Rev Inst Med Trop Sao Paulo 50:79-82
    ....