seeds

Summary

Summary: The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.

Top Publications

  1. pmc LEAFY COTYLEDON1-LIKE defines a class of regulators essential for embryo development
    Raymond W Kwong
    Section of Plant Biology, Division of Biological Sciences, One Shields Avenue, University of California, Davis, California 95616, USA
    Plant Cell 15:5-18. 2003
  2. pmc Abscisic acid signaling in seeds and seedlings
    Ruth R Finkelstein
    Department of Molecular, Cellular, and Developmental Biology, University of California at Santa Barbara, Santa Barbara, CA 93106, USA
    Plant Cell 14:S15-45. 2002
  3. pmc Identification of miRNAs and their target genes in developing soybean seeds by deep sequencing
    Qing Xin Song
    State Key Laboratory of Plant Genomics, Genome Biology Center, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, PR China
    BMC Plant Biol 11:5. 2011
  4. ncbi NRT/PTR transporters are essential for translocation of glucosinolate defence compounds to seeds
    Hussam Hassan Nour-Eldin
    Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, 1871Frederiksberg C, Denmark
    Nature 488:531-4. 2012
  5. pmc F-box proteins in rice. Genome-wide analysis, classification, temporal and spatial gene expression during panicle and seed development, and regulation by light and abiotic stress
    Mukesh Jain
    Interdisciplinary Centre for Plant Genomics and Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110 021, India
    Plant Physiol 143:1467-83. 2007
  6. ncbi ABA induction of miR159 controls transcript levels of two MYB factors during Arabidopsis seed germination
    Jose L Reyes
    Laboratory of Plant Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Plant J 49:592-606. 2007
  7. pmc Association mapping of kernel size and milling quality in wheat (Triticum aestivum L.) cultivars
    Flavio Breseghello
    Department of Plant Breeding and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genetics 172:1165-77. 2006
  8. ncbi Seed dormancy and the control of germination
    William E Finch-Savage
    Warwick HRI, Warwick University, Wellesbourne, Warwick CV35 9EF, UK
    New Phytol 171:501-23. 2006
  9. pmc The Arabidopsis cytochrome P450 CYP707A encodes ABA 8'-hydroxylases: key enzymes in ABA catabolism
    Tetsuo Kushiro
    Plant Science Center, RIKEN, Yokohama, Japan
    EMBO J 23:1647-56. 2004
  10. ncbi Cereal seed storage proteins: structures, properties and role in grain utilization
    Peter R Shewry
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, Long Ashton, Bristol BS41 9AF, UK
    J Exp Bot 53:947-58. 2002

Detail Information

Publications303 found, 100 shown here

  1. pmc LEAFY COTYLEDON1-LIKE defines a class of regulators essential for embryo development
    Raymond W Kwong
    Section of Plant Biology, Division of Biological Sciences, One Shields Avenue, University of California, Davis, California 95616, USA
    Plant Cell 15:5-18. 2003
    ..Our results also suggest that LEC1-type HAP3 subunits arose from a common origin uniquely in plants. Thus, L1L, an essential regulator of embryo development, defines a unique class of plant HAP3 subunits...
  2. pmc Abscisic acid signaling in seeds and seedlings
    Ruth R Finkelstein
    Department of Molecular, Cellular, and Developmental Biology, University of California at Santa Barbara, Santa Barbara, CA 93106, USA
    Plant Cell 14:S15-45. 2002
  3. pmc Identification of miRNAs and their target genes in developing soybean seeds by deep sequencing
    Qing Xin Song
    State Key Laboratory of Plant Genomics, Genome Biology Center, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, PR China
    BMC Plant Biol 11:5. 2011
    ....
  4. ncbi NRT/PTR transporters are essential for translocation of glucosinolate defence compounds to seeds
    Hussam Hassan Nour-Eldin
    Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, 1871Frederiksberg C, Denmark
    Nature 488:531-4. 2012
    ..in the plant model Arabidopsis, in which the major defence compounds, glucosinolates, are translocated to seeds on maturation...
  5. pmc F-box proteins in rice. Genome-wide analysis, classification, temporal and spatial gene expression during panicle and seed development, and regulation by light and abiotic stress
    Mukesh Jain
    Interdisciplinary Centre for Plant Genomics and Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110 021, India
    Plant Physiol 143:1467-83. 2007
    ..The structure and function of F-box proteins in plants is discussed in light of these results and the published information. These data will be useful for prioritization of F-box proteins for functional validation in rice...
  6. ncbi ABA induction of miR159 controls transcript levels of two MYB factors during Arabidopsis seed germination
    Jose L Reyes
    Laboratory of Plant Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Plant J 49:592-606. 2007
    ..Here, we show that, in germinating Arabidopsis thaliana seeds, ABA induces the accumulation of microRNA 159 (miR159) in an ABI3-dependent fashion, and miRNA159 mediates ..
  7. pmc Association mapping of kernel size and milling quality in wheat (Triticum aestivum L.) cultivars
    Flavio Breseghello
    Department of Plant Breeding and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genetics 172:1165-77. 2006
    ..Our results demonstrated that association mapping could complement and enhance previous QTL information for marker-assisted selection...
  8. ncbi Seed dormancy and the control of germination
    William E Finch-Savage
    Warwick HRI, Warwick University, Wellesbourne, Warwick CV35 9EF, UK
    New Phytol 171:501-23. 2006
    ..We argue that adaptation has taken place on a theme rather than via fundamentally different paths and identify similarities underlying the extensive diversity in the dormancy response to the environment that controls germination...
  9. pmc The Arabidopsis cytochrome P450 CYP707A encodes ABA 8'-hydroxylases: key enzymes in ABA catabolism
    Tetsuo Kushiro
    Plant Science Center, RIKEN, Yokohama, Japan
    EMBO J 23:1647-56. 2004
    ..Consistent with the expression analyses, cyp707a2 mutants exhibited hyperdormancy in seeds and accumulated six-fold greater ABA content than wild type...
  10. ncbi Cereal seed storage proteins: structures, properties and role in grain utilization
    Peter R Shewry
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, Long Ashton, Bristol BS41 9AF, UK
    J Exp Bot 53:947-58. 2002
    ..The role of the gluten proteins of wheat in determining the quality of the grain for breadmaking and how their amount and composition can be manipulated leading to changes in dough mixing properties is also discussed...
  11. pmc Arabidopsis cytokinin receptor mutants reveal functions in shoot growth, leaf senescence, seed size, germination, root development, and cytokinin metabolism
    Michael Riefler
    Institute of Biology Applied Genetics, Free University of Berlin, Germany
    Plant Cell 18:40-54. 2006
    ..Mutant seeds had more rapid germination, reduced requirement for light, and decreased far-red light sensitivity, unraveling ..
  12. ncbi Three Arabidopsis SnRK2 protein kinases, SRK2D/SnRK2.2, SRK2E/SnRK2.6/OST1 and SRK2I/SnRK2.3, involved in ABA signaling are essential for the control of seed development and dormancy
    Kazuo Nakashima
    Biological Resources Division, Japan International Research Center for Agricultural Sciences JIRCAS, Ibaraki, Japan
    Plant Cell Physiol 50:1345-63. 2009
    ..Microarray experiments revealed that 48 and 30% of the down-regulated genes in abi5 and abi3 seeds were suppressed in the triple mutant seeds, respectively...
  13. ncbi Molecular networks regulating Arabidopsis seed maturation, after-ripening, dormancy and germination
    Michael J Holdsworth
    Department of Agricultural and Environmental Sciences, School of Biosciences, University of Nottingham, Nottingham LE12 5RD, UK
    New Phytol 179:33-54. 2008
    ..Combined postgenomics, physiology and molecular genetics approaches are beginning to provide an unparalleled understanding of the molecular processes underlying dormancy and germination...
  14. ncbi A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
    Xian Jun Song
    National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institute for Biological Sciences, The Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China
    Nat Genet 39:623-30. 2007
    ..The functional characterization of GW2 provides insight into the mechanism of seed development and is a potential tool for improving grain yield in crops...
  15. pmc Genetic structure and domestication history of the grape
    Sean Myles
    Institute for Genomic Diversity, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 108:3530-5. 2011
    ..The grape currently faces severe pathogen pressures, and the long-term sustainability of the grape and wine industries will rely on the exploitation of the grape's tremendous natural genetic diversity...
  16. ncbi Molecular aspects of seed dormancy
    Ruth Finkelstein
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, California 93106 9610, USA
    Annu Rev Plant Biol 59:387-415. 2008
    ..The net result is a slightly heterogeneous response, thereby providing more temporal options for successful germination...
  17. ncbi GS3, a major QTL for grain length and weight and minor QTL for grain width and thickness in rice, encodes a putative transmembrane protein
    Chuchuan Fan
    National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research Wuhan, Huazhong Agricultural University, 430070 Wuhan, China
    Theor Appl Genet 112:1164-71. 2006
    ..Cloning of such a gene provided the opportunity for fully characterizing the regulatory mechanism and related processes during grain development...
  18. pmc Ectopic expression of BABY BOOM triggers a conversion from vegetative to embryonic growth
    Kim Boutilier
    Plant Research International, Wageningen, The Netherlands
    Plant Cell 14:1737-49. 2002
    ..to the AP2/ERF family of transcription factors and is expressed preferentially in developing embryos and seeds. Ectopic expression of BBM in Arabidopsis and Brassica led to the spontaneous formation of somatic embryos and ..
  19. ncbi ABI5 acts downstream of ABI3 to execute an ABA-dependent growth arrest during germination
    Luis Lopez-Molina
    Laboratory of Plant Molecular Biology, Laboratory for Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Plant J 32:317-28. 2002
    ..Although ABI5 is consistently located in the nucleus, chromosomal immunoprecipitation (ChIP) experiments revealed that ABA increases ABI5 occupancy on the AtEm6 promoter...
  20. pmc Global analysis of gene activity during Arabidopsis seed development and identification of seed-specific transcription factors
    Brandon H Le
    Department of Molecular, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:8063-70. 2010
    ..To identify TF genes expressed at specific stages of seed development, including those unique to seeds, we used Affymetrix GeneChips to profile Arabidopsis genes active in seeds from fertilization through maturation ..
  21. ncbi Genetics and biochemistry of seed flavonoids
    Loic Lepiniec
    Seed Biology, Institut Jean Pierre Bourgin IJPB, INRA, 78026 Versailles, France
    Annu Rev Plant Biol 57:405-30. 2006
    Flavonoids are secondary metabolites that accumulate in most plant seeds and are involved in physiological functions such as dormancy or viability...
  22. pmc MOTHER OF FT AND TFL1 regulates seed germination through a negative feedback loop modulating ABA signaling in Arabidopsis
    Wanyan Xi
    Department of Biological Sciences and Temasek Life Sciences Laboratory, National University of Singapore, 117543, Singapore
    Plant Cell 22:1733-48. 2010
    ..In germinating seeds, MFT expression is directly regulated by ABA-INSENSITIVE3 (ABI3) and ABI5, two key transcription factors in ABA ..
  23. pmc Large-scale production of functional human serum albumin from transgenic rice seeds
    Yang He
    Engineering Research Center for Plant Biotechnology and Germplasm Utilization, Ministry of Education, State Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan 430072, China
    Proc Natl Acad Sci U S A 108:19078-83. 2011
    ..Here, we report the production of Oryza sativa recombinant HSA (OsrHSA) from transgenic rice seeds. The level of OsrHSA reached 10.58% of the total soluble protein of the rice grain...
  24. ncbi Characterization of metabolite quantitative trait loci and metabolic networks that control glucosinolate concentration in the seeds and leaves of Brassica napus
    Ji Feng
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China
    New Phytol 193:96-108. 2012
    ..dissected through analysis of total glucosinolate concentration and its individual components in both leaves and seeds of a doubled-haploid (DH) mapping population of oilseed rape/canola (Brassica napus)...
  25. pmc Tung tree DGAT1 and DGAT2 have nonredundant functions in triacylglycerol biosynthesis and are localized to different subdomains of the endoplasmic reticulum
    Jay M Shockey
    U S Department of Agriculture, Agricultural Research Service, Southern Regional Research Center, New Orleans, Louisiana 70124, USA
    Plant Cell 18:2294-313. 2006
    b>Seeds of the tung tree (Vernicia fordii) produce large quantities of triacylglycerols (TAGs) containing approximately 80% eleostearic acid, an unusual conjugated fatty acid...
  26. ncbi An SNP caused loss of seed shattering during rice domestication
    Saeko Konishi
    Institute of the Society for Techno Innovation of Agriculture, Forestry, and Fisheries, 446 1 Ippaizuka, Kamiyokoba Tsukuba, Ibaraki 305 0854, Japan
    Science 312:1392-6. 2006
    ....
  27. pmc CYP707A1 and CYP707A2, which encode abscisic acid 8'-hydroxylases, are indispensable for proper control of seed dormancy and germination in Arabidopsis
    Masanori Okamoto
    RIKEN Plant Science Center, Yokohama, Kanagawa 230 0045, Japan
    Plant Physiol 141:97-107. 2006
    ..encode ABA 8'-hydroxylases, and that the cyp707a2 mutants showed an increase in ABA levels in dry and imbibed seeds. In this study, we showed that the cyp707a1 mutant accumulated ABA to higher levels in dry seeds than the cyp707a2 ..
  28. pmc Identification and characterization of maize microRNAs involved in the very early stage of seed germination
    Liwen Wang
    State Key Laboratory of Crop Biology, Shandong Agricultural University, Taian, Shandong 271018, PR China
    BMC Genomics 12:154. 2011
    ..However, the number of miRNAs discovered in maize is relatively low and little is known about miRNAs involved in the very early stage during seed germination...
  29. ncbi Arabidopsis LEAFY COTYLEDON1 is sufficient to induce embryo development in vegetative cells
    T Lotan
    Division of Biological Sciences, University of California, Davis 95616, USA
    Cell 93:1195-205. 1998
    ..Our results suggest that LEC1 is an important regulator of embryo development that activates the transcription of genes required for both embryo morphogenesis and cellular differentiation...
  30. ncbi The AtGenExpress hormone and chemical treatment data set: experimental design, data evaluation, model data analysis and data access
    Hideki Goda
    RIKEN Plant Science Center, Tsurumi, Yokohama, Kanagawa 230 0045, Japan
    Plant J 55:526-42. 2008
    ..The data set presented here will be a versatile resource for future hormone studies, and constitutes a reference for genome-wide gene expression in Arabidopsis...
  31. ncbi A comparative linkage map of oilseed rape and its use for QTL analysis of seed oil and erucic acid content
    D Qiu
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, 1 Shizishan, 430070, Wuhan, China
    Theor Appl Genet 114:67-80. 2006
    ..The results provide new insights into the genetic control of seed oil and erucic acid content in oilseed rape, and demonstrate the utility of the linkage map and population...
  32. pmc Genome-wide network model capturing seed germination reveals coordinated regulation of plant cellular phase transitions
    George W Bassel
    Division of Plant and Crop Sciences, School of Biosciences and Centre for Plant Integrative Biology, University of Nottingham, Loughborough LE12 5RD, United Kingdom
    Proc Natl Acad Sci U S A 108:9709-14. 2011
    ..SeedNet is available as a community resource (http://vseed.nottingham.ac.uk) to aid dissection of this complex trait and gene function in diverse processes...
  33. pmc LEAFY COTYLEDON2 encodes a B3 domain transcription factor that induces embryo development
    S L Stone
    Section of Plant Biology, Division of Biological Sciences, University of California, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 98:11806-11. 2001
    ..that LEC2 shares greatest similarity with the B3 domain transcription factors that act primarily in developing seeds, VIVIPAROUS1/ABA INSENSITIVE3 and FUSCA3...
  34. pmc Metabolic engineering plant seeds with fish oil-like levels of DHA
    James R Petrie
    CSIRO Food Futures National Research Flagship, Canberra, Australian Capital Territory, Australia
    PLoS ONE 7:e49165. 2012
    ....
  35. pmc The tomato homolog of CORONATINE-INSENSITIVE1 is required for the maternal control of seed maturation, jasmonate-signaled defense responses, and glandular trichome development
    Lei Li
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Cell 16:126-43. 2004
    ..These findings indicate that the JA/COI1 signaling pathway regulates distinct developmental processes in different plants and suggest a role for JA in the promotion of glandular trichome-based defenses...
  36. pmc MicroRNAs regulate the timing of embryo maturation in Arabidopsis
    Matthew R Willmann
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Plant Physiol 155:1871-84. 2011
    ..Mature seeds are dormant and desiccated, with accumulated storage products that are to be used by the seedling after ..
  37. ncbi Genome-wide analysis of endogenous abscisic acid-mediated transcription in dry and imbibed seeds of Arabidopsis using tiling arrays
    Masanori Okamoto
    RIKEN Plant Science Center, Yokohama, Kanagawa 230 0045, Japan
    Plant J 62:39-51. 2010
    ..To understand how endogenous ABA regulates the transcriptomes in seeds, we performed comprehensive expression analyses using whole-genome Affymetrix tiling arrays in two ABA metabolism ..
  38. pmc Unraveling the complex trait of crop yield with quantitative trait loci mapping in Brassica napus
    Jiaqin Shi
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China
    Genetics 182:851-61. 2009
    ..The idea of estimating indicator QTL for yield QTL and identifying potential candidate genes for yield provides an advance in methodology for complex traits...
  39. pmc MicroRNAs prevent precocious gene expression and enable pattern formation during plant embryogenesis
    Michael D Nodine
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Genes Dev 24:2678-92. 2010
    ..We propose that, by preventing precocious expression of differentiation-promoting transcription factors, miRNAs enable proper embryonic patterning...
  40. ncbi Increasing seed oil content in oil-seed rape (Brassica napus L.) by over-expression of a yeast glycerol-3-phosphate dehydrogenase under the control of a seed-specific promoter
    Helene Vigeolas
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Plant Biotechnol J 5:431-41. 2007
    ..dehydrogenase activity led to a three- to fourfold increase in the level of glycerol-3-phosphate in developing seeds, resulting in a 40% increase in the final lipid content of the seed, with the protein content remaining ..
  41. ncbi Comparative organization of chloroplast, mitochondrial and nuclear diversity in plant populations
    Remy J Petit
    INRA, UMR Biodiversity, Genes and Ecosystems, 69 route d Arcachon, F 33612 Cestas cedex, France
    Mol Ecol 14:689-701. 2005
    ....
  42. pmc The Arabidopsis abscisic acid response gene ABI5 encodes a basic leucine zipper transcription factor
    R R Finkelstein
    Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, California 93106, USA
    Plant Cell 12:599-609. 2000
    ..Comparison of seed and ABA-inducible vegetative gene expression in wild-type and abi5-1 plants indicates that ABI5 regulates a subset of late embryogenesis-abundant genes during both developmental stages...
  43. ncbi Genome-wide profiling of stored mRNA in Arabidopsis thaliana seed germination: epigenetic and genetic regulation of transcription in seed
    Kazumi Nakabayashi
    Plant Science Center, RIKEN, Suehiro cho 1 7 22, Tsurumi, Yokohama, Kanagawa 230 0045, Japan
    Plant J 41:697-709. 2005
    ..Statistical analysis revealed that promoters of highly expressed genes in wild-type dry seeds overrepresented abscisic acid-responsive elements (ABREs) containing the core motif ACGT...
  44. pmc A postgermination developmental arrest checkpoint is mediated by abscisic acid and requires the ABI5 transcription factor in Arabidopsis
    L Lopez-Molina
    Laboratory of Plant Molecular Biology, The Rockefeller University, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 98:4782-7. 2001
    ..Understanding how seeds break dormancy and initiate growth is also of great agricultural and biotechnological interest...
  45. pmc Seed-specific over-expression of an Arabidopsis cDNA encoding a diacylglycerol acyltransferase enhances seed oil content and seed weight
    C Jako
    Seed Oil Biotechnology Group, National Research Council of Canada, Plant Biotechnology Institute, 110 Gymnasium Place, Saskatoon, Saskatchewan S7N 0W9, Canada
    Plant Physiol 126:861-74. 2001
    ..The DGAT activity in developing seed of transgenic lines was enhanced by 10% to 70%. Thus, the current study confirms the important role of DGAT in regulating the quantity of seed triacylglycerols and the sink size in developing seeds.
  46. pmc A cytosolic acyltransferase contributes to triacylglycerol synthesis in sucrose-rescued Arabidopsis seed oil catabolism mutants
    M Luisa Hernandez
    Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, United Kingdom
    Plant Physiol 160:215-25. 2012
    ..We show that TAG composition changes significantly in Suc-rescued seedlings compared with that found in dry seeds, with 18:2 and 18:3 accumulating...
  47. pmc The time required for dormancy release in Arabidopsis is determined by DELAY OF GERMINATION1 protein levels in freshly harvested seeds
    Kazumi Nakabayashi
    Department of Plant Breeding and Genetics, Max Planck Institute for Plant Breeding Research, 50829 Cologne, Germany
    Plant Cell 24:2826-38. 2012
    ..Freshly harvested seeds usually show a high level of dormancy, which is gradually released during dry storage (after-ripening)...
  48. ncbi Transgenic maize plants expressing a fungal phytase gene
    Rumei Chen
    Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, P R China
    Transgenic Res 17:633-43. 2008
    Maize seeds are the major ingredient of commercial pig and poultry feed. Phosphorus in maize seeds exists predominantly in the form of phytate...
  49. ncbi Identification of reference genes for RT-qPCR expression analysis in Arabidopsis and tomato seeds
    Bas J W Dekkers
    Wageningen Seed Laboratory, Laboratory of Plant Physiology, Wageningen University, Wageningen, The Netherlands
    Plant Cell Physiol 53:28-37. 2012
    ..Since transcriptomes of seeds are different from other plant tissues, we aimed to identify reference genes specifically for RT-qPCR analyses in ..
  50. pmc Insecticidal activity of the essential oil from fruits and seeds of Schinus terebinthifolia Raddi against African malaria vectors
    Eliningaya J Kweka
    Tropical Pesticides Research Institute, Division of Livestock and Human Disease Vectors Control, Mosquitoes Section, POBox 3024, Arusha, Tanzania
    Parasit Vectors 4:129. 2011
    ..In this study, mosquitocidal activity of Schinus terebinthifolia essential oil against Anopheles gambiae s.s., An. arabiensis and Culex quinquefasciatus was assessed in laboratory, semi- field and full- field conditions..
  51. pmc Gene expression analysis of flax seed development
    Prakash Venglat
    Plant Biotechnology Institute, NRC, 110 Gymnasium Place, Saskatoon, Saskatchewan, S7N 0W9, Canada
    BMC Plant Biol 11:74. 2011
    ..is an important crop whose seed oil and stem fiber have multiple industrial applications. Flax seeds are also well-known for their nutritional attributes, viz...
  52. ncbi Expression of ER quality control-related genes in response to changes in BiP1 levels in developing rice endosperm
    Yuhya Wakasa
    Transgenic Crop Research and Development Center, National Institute of Agrobiological Sciences, Kannondai 2 1 2, Tsukuba, Ibaraki 305 8602, Japan
    Plant J 65:675-89. 2011
    ..Judicious modification of BiP1 levels in transgenic rice can provide suitable conditions for the production of secretory proteins by alleviating ER stress...
  53. ncbi Repression of AUXIN RESPONSE FACTOR10 by microRNA160 is critical for seed germination and post-germination stages
    Po Pu Liu
    Department of Horticulture, Oregon State University, Corvallis, OR 97331, USA
    Plant J 52:133-46. 2007
    ..During sensu stricto germination and post-germination, mARF10 mutant seeds and plants were hypersensitive to ABA in a dose-dependent manner...
  54. pmc Genomic diversity and introgression in O. sativa reveal the impact of domestication and breeding on the rice genome
    Keyan Zhao
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, USA
    PLoS ONE 5:e10780. 2010
    ..However, genetic uniformity surrounding key domestication genes across divergent subpopulations suggests cultural exchange of genetic material among ancient farmers...
  55. ncbi Differential expression of the microRNAs in superior and inferior spikelets in rice (Oryza sativa)
    Ting Peng
    Research Center for Rice Engineering and Key Laboratory of Physiology, Ecology and Genetic Improvement of Food Crops in Henan Province, Henan Agricultural University, Zhengzhou, 450002, China
    J Exp Bot 62:4943-54. 2011
    ..The results indicate that the slow grain-filling and low grain weight of rice inferior spikelets are attributed partly to differences in expression and function between superior and inferior spikelet miRNAs...
  56. pmc Cytokinin regulates the activity of reproductive meristems, flower organ size, ovule formation, and thus seed yield in Arabidopsis thaliana
    Isabel Bartrina
    Institute of Biology Applied Genetics, Dahlem Centre of Plant Sciences, Freie Universitat Berlin, D 14195 Berlin, Germany
    Plant Cell 23:69-80. 2011
    ..Together, the results underpin the important role of cytokinin in reproductive development. The increased cytokinin content caused an ~55% increase in seed yield, highlighting the relevance of sink strength as a yield factor...
  57. ncbi Long-distance dispersal of plants
    Ran Nathan
    Movement Ecology Laboratory, Department of Evolution, Systematics and Ecology, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Givat Ram, 91904 Jerusalem, Israel
    Science 313:786-8. 2006
    ..Nonstandard" mechanisms such as extreme climatic events and generalized LDD vectors seem to hold the greatest explanatory power for the drastic deviations from the mean trend, deviations that make the nearly impossible LDD a reality...
  58. pmc The calcium sensor calcineurin B-like 9 modulates abscisic acid sensitivity and biosynthesis in Arabidopsis
    Girdhar K Pandey
    Department of Plant and Microbial Biology, University of California, Berkeley 94720, USA
    Plant Cell 16:1912-24. 2004
    ..This study has identified a calcium sensor as a common element in the ABA signaling and stress-induced ABA biosynthesis pathways...
  59. ncbi The AUXIN RESPONSE FACTOR 2 gene of Arabidopsis links auxin signalling, cell division, and the size of seeds and other organs
    Marie C Schruff
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Development 133:251-61. 2006
    ..The mutant phenotype also illustrates the importance of growth of the ovule before fertilization in determining final size of the seed...
  60. ncbi The plant hormone abscisic acid mediates the drought-induced expression but not the seed-specific expression of rd22, a gene responsive to dehydration stress in Arabidopsis thaliana
    K Yamaguchi-Shinozaki
    Laboratory of Plant Molecular Biology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Mol Gen Genet 238:17-25. 1993
    ..thaliana genome, while the gene for USP from V. faba is actually a family of genes with 10 to 20 members.(ABSTRACT TRUNCATED AT 250 WORDS)..
  61. pmc Transcriptome analysis of grain development in hexaploid wheat
    Yongfang Wan
    Rothamsted Research, Harpenden, Hertfordshire, UK
    BMC Genomics 9:121. 2008
    ..Molecular understanding of the biology of the developing grain will assist the improvement of yield and quality traits for different environments. High quality transcriptomics is a powerful method to increase this understanding...
  62. ncbi Family life at close quarters: communication and constraint in angiosperm seed development
    Gwyneth Christina Ingram
    Institute of Molecular Plant Sciences, University of Edinburgh, Edinburgh, UK
    Protoplasma 247:195-214. 2010
    The formation of viable angiosperm seeds involves the co-ordinated growth and development of three genetically distinct organisms, the maternally derived seed coat and the zygotic embryo and endosperm...
  63. ncbi Arabidopsis NF-YB subunits LEC1 and LEC1-LIKE activate transcription by interacting with seed-specific ABRE-binding factors
    Akiko Yamamoto
    Bioscience and Biotechnology Center, Nagoya University, Chikusa ku, Nagoya, Japan
    Plant J 58:843-56. 2009
    ..These results demonstrate a novel plant-specific mechanism for NF-Y subunit function that enables LEC1 and L1L to regulate a defined developmental network...
  64. pmc Genome-wide analysis of genes targeted by PHYTOCHROME INTERACTING FACTOR 3-LIKE5 during seed germination in Arabidopsis
    Eunkyoo Oh
    Department of Biological Sciences, KAIST, Daejeon 305 701, Korea
    Plant Cell 21:403-19. 2009
    ..Taken together, our data indicate that PIL5 inhibits seed germination not just through GA and ABA, but also by coordinating hormone signals and modulating cell wall properties in imbibed seeds.
  65. pmc The gibberellic acid signaling repressor RGL2 inhibits Arabidopsis seed germination by stimulating abscisic acid synthesis and ABI5 activity
    Urszula Piskurewicz
    Universite de Geneve, Département de Biologie Végétale, 1211 Geneva 4, Switzerland
    Plant Cell 20:2729-45. 2008
    ..In sleepy1 mutant seeds, RGL2 overaccumulates; germination of these seeds can occur under conditions that produce low ABI5 expression...
  66. pmc A novel transcriptional cascade regulating expression of heat stress proteins during seed development of Arabidopsis
    Sachin Kotak
    Institute of Molecular Biosciences, Biocenter N200 R306, Goethe University, D 60439 Frankfurt, Germany
    Plant Cell 19:182-95. 2007
    ..Consequently, the most abundant heat stress proteins (Hsps) in seeds (Hsp17.4-CI, Hsp17...
  67. pmc Genetic analysis of functions involved in adhesion of Pseudomonas putida to seeds
    M Espinosa-Urgel
    Department of Plant Biochemistry, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, E 18008 Granada, Spain
    J Bacteriol 182:2363-9. 2000
    ..require the establishment of efficient bacterial populations in the rhizosphere, for which colonization of plant seeds often constitutes a critical first step...
  68. pmc Gibberellin regulates Arabidopsis seed germination via RGL2, a GAI/RGA-like gene whose expression is up-regulated following imbibition
    Sorcheng Lee
    Institute of Molecular Agrobiology, National University of Singapore, Singapore 117604
    Genes Dev 16:646-58. 2002
    The germination of Arabidopsis seeds is promoted by gibberellin (GA). Arabidopsis GAI, and RGA are genes encoding key GA signal-transduction components (GAI and RGA) that mediate GA regulation of stem elongation...
  69. pmc Function and characterization of starch synthase I using mutants in rice
    Naoko Fujita
    Department of Biological Production, Akita Prefectural University, Akita City, Japan
    Plant Physiol 140:1070-84. 2006
    ..of SSI, despite being a major SS isozyme in the developing endosperm, had no effect on the size and shape of seeds and starch granules and the crystallinity of endosperm starch, suggesting that other SS enzymes are probably ..
  70. pmc Suppression of sucrose synthase gene expression represses cotton fiber cell initiation, elongation, and seed development
    Yong Ling Ruan
    Commonwealth Scientific and Industrial Research Organization Plant Industry, Canberra, ACT 2601, Australia
    Plant Cell 15:952-64. 2003
    ..By 25 DAA, a portion of the seeds in the fruit showed Sus suppression only in the seed coat fibers and transfer cells but not in the endosperm and ..
  71. pmc High-resolution analysis of parent-of-origin allelic expression in the Arabidopsis Endosperm
    Philip Wolff
    Department of Biology and Zurich Basel Plant Science Center, Swiss Federal Institute of Technology, Zurich, Switzerland
    PLoS Genet 7:e1002126. 2011
    ..to identify novel imprinted genes in Arabidopsis thaliana, we generated deep sequencing RNA profiles of F1 hybrid seeds derived after reciprocal crosses of Arabidopsis Col-0 and Bur-0 accessions...
  72. ncbi Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis
    De Yu Xie
    Plant Biology Division, Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
    Science 299:396-9. 2003
    ..Ectopic expression of BAN in tobacco flower petals and Arabidopsis leaves results in loss of anthocyanins and accumulation of CTs...
  73. pmc Gene coexpression clusters and putative regulatory elements underlying seed storage reserve accumulation in Arabidopsis
    Fred Y Peng
    Agricultural Lipid Biotechnology Program, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada
    BMC Genomics 12:286. 2011
    ..A more holistic view of this molecular interplay will help in the further study of the regulatory mechanisms controlling seed storage compound accumulation...
  74. pmc The tolerance-fecundity trade-off and the maintenance of diversity in seed size
    Helene C Muller-Landau
    Smithsonian Tropical Research Institute, DPO AA 34002 9998
    Proc Natl Acad Sci U S A 107:4242-7. 2010
    ..small-seeded species clearly have the advantage in fecundity, but what is the countervailing advantage of large seeds? Higher competitive ability combined with strong competitive asymmetry can in theory allow coexistence through a ..
  75. ncbi From the soil to the seeds: the long journey of nitrate in plants
    Julie Dechorgnat
    Institut Jean Pierre Bourgin, UMR 1318 INRA AgroParisTech, Institut National de la Recherche Agronomique, Route de St Cyr, F 78026 Versailles, France
    J Exp Bot 62:1349-59. 2011
    ..All these fluxes are controlled by key factors, the 'major tour operators' like the internal nutritional status of the plant but also by external abiotic factors...
  76. ncbi Pharmacological and toxicological properties of Nigella sativa
    B H Ali
    Department of Veterinary Medicine, King Saud University, Buraydah, Al Gaseem 81999, Saudi Arabia
    Phytother Res 17:299-305. 2003
    The seeds of Nigella sativa Linn...
  77. ncbi Natural variation in GS5 plays an important role in regulating grain size and yield in rice
    Yibo Li
    National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research, Huazhong Agricultural University, Wuhan, China
    Nat Genet 43:1266-9. 2011
    ..The results suggest that natural variation in GS5 contributes to grain size diversity in rice and may be useful in improving yield in rice and, potentially, other crops(2)...
  78. pmc Extensive demethylation of repetitive elements during seed development underlies gene imprinting
    Mary Gehring
    Howard Hughes Medical Institute HHMI, Fred Hutchinson Cancer Research Center FHCRC, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 324:1447-51. 2009
    ..These data suggest that imprinting in plants evolved from targeted methylation of transposable element insertions near genic regulatory elements followed by positive selection when the resulting expression change was advantageous...
  79. ncbi Expression profiling of genes involved in starch synthesis in sink and source organs of rice
    Takashi Ohdan
    Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Agency JST, 4 1 8, Honcho, Kawaguchi, Saitama 332 0012, Japan
    J Exp Bot 56:3229-44. 2005
    ..branching enzyme, starch debranching enzyme, starch phosphorylase, and disproportionating enzyme in developing seeds and leaves. The modes of gene expression were tissue- and developmental stage-specific...
  80. ncbi Early infection of scutellum tissue with Agrobacterium allows high-speed transformation of rice
    Seiichi Toki
    Plant Genetic Engineering Research Unit, National Institute of Agrobiological Sciences, 2 1 2 Kannondai, Tsukuba, Ibaraki 305 8602, Japan
    Plant J 47:969-76. 2006
    ..Here, we report the competency of scutellum tissue from 1-day pre-cultured seeds for Agrobacterium-mediated transformation...
  81. ncbi Apyap1 affects aflatoxin biosynthesis during Aspergillus parasiticus growth in maize seeds
    M Reverberi
    Universita degli Studi La Sapienza, 00165 Rome, Italy
    Food Addit Contam 24:1070-5. 2007
    ..This study suggests that an association between oxidative stress and aflatoxin biosynthesis also occurs in maize seeds. We used DeltaApyap1, a strain in which the gene Apyap1 was disrupted, to verify whether this oxidative stress-..
  82. ncbi High-throughput peptide mass fingerprinting of soybean seed proteins: automated workflow and utility of UniGene expressed sequence tag databases for protein identification
    Brian P Mooney
    Department of Biochemistry and Proteomics Center, University of Missouri Columbia, 125 Chemistry, Columbia, MO 65211, USA
    Phytochemistry 65:1733-44. 2004
    ..This survey of anonymous seed proteins will serve as the basis for future comparative analysis of seed-filling in soybean as well as comparisons with other soybean varieties...
  83. pmc Mutations in UDP-Glucose:sterol glucosyltransferase in Arabidopsis cause transparent testa phenotype and suberization defect in seeds
    Seth DeBolt
    Department of Horticulture, University of Kentucky, Lexington, Kentucky 40506, USA
    Plant Physiol 151:78-87. 2009
    ..An ancillary observation was that cellulose biosynthesis was unaffected in the double mutant, inconsistent with a predicted role for SGs in priming cellulose synthesis...
  84. ncbi Seed dormancy and germination
    Maarten Koornneef
    Laboratory of Genetics, Department of Plant Sciences, Wageningen University, Arboretumlaan 4, 6703 BD, Wageningen, The Netherlands
    Curr Opin Plant Biol 5:33-6. 2002
    ..These tools preferentially use Arabidopsis thaliana because of the molecular genetic resources available for this species. However, Solanaceae and cereals also provide important models for dormancy research...
  85. ncbi A conditionally fertile coi1 allele indicates cross-talk between plant hormone signalling pathways in Arabidopsis thaliana seeds and young seedlings
    Christine Ellis
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Planta 215:549-56. 2002
    ..We have used coi1-16 seeds to define novel interactions between JA and other hormone signalling pathways in seed germination and in the ..
  86. pmc Biochemical and genetic analysis of the effects of amylose-extender mutation in rice endosperm
    A Nishi
    Faculty of Agriculture, Kyushu University, Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Plant Physiol 127:459-72. 2001
    ..These results strongly suggest that BEIIb plays a specific role in the transfer of short chains, which might then be extended by SS to form the A and B(1) chains of amylopectin cluster in rice endosperm...
  87. pmc Endogenous, tissue-specific short interfering RNAs silence the chalcone synthase gene family in glycine max seed coats
    Jigyasa H Tuteja
    Department of Crop Sciences, University of Illinois, Urbana, Illinois 61801, USA
    Plant Cell 21:3063-77. 2009
    ....
  88. ncbi Arabidopsis seed secrets unravelled after a decade of genetic and omics-driven research
    Helen North
    INRA, Seed Biology Laboratory, Institut Jean Pierre Bourgin IJPB, UMR 204 INRA AgroParisTech, Versailles Cedex, France
    Plant J 61:971-81. 2010
    b>Seeds play a fundamental role in colonization of the environment by spermatophytes, and seeds harvested from crops are the main food source for human beings...
  89. pmc Class III homeodomain-leucine zipper gene family members have overlapping, antagonistic, and distinct roles in Arabidopsis development
    Michael J Prigge
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, An Arbor, Michigan 48109 1048, USA
    Plant Cell 17:61-76. 2005
    ..Differences in expression patterns explain some of these genetic interactions, whereas other interactions are likely attributable to differences in protein function as indicated by cross-complementation studies...
  90. pmc Strigolactones stimulate arbuscular mycorrhizal fungi by activating mitochondria
    Arnaud Besserer
    UMR 5546, Pôle de Biotechnologies Végétales, Castanet Tolosan, France
    PLoS Biol 4:e226. 2006
    ..intraradices. We conclude that strigolactones are important rhizospheric plant signals involved in stimulating both the pre-symbiotic growth of AM fungi and the germination of parasitic plants...
  91. ncbi Subcellular targeting is a key condition for high-level accumulation of cellulase protein in transgenic maize seed
    Elizabeth E Hood
    Arkansas State University, PO Box 2760, State University, AR 72467, USA
    Plant Biotechnol J 5:709-19. 2007
    ..Recovery of high levels of enzyme in T2 ears demonstrated that expression is likely to be stable over multiple generations. The enzymes were active in cleaving soluble substrate...
  92. ncbi DEMETER, a DNA glycosylase domain protein, is required for endosperm gene imprinting and seed viability in arabidopsis
    Yeonhee Choi
    Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell 110:33-42. 2002
    ..In leaf, ectopic DME expression induces MEA and nicks the MEA promoter. Thus, a DNA glycosylase activates maternal expression of an imprinted gene in the central cell...
  93. pmc Genome-wide demethylation of Arabidopsis endosperm
    Tzung Fu Hsieh
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Science 324:1451-4. 2009
    ..Our findings demonstrate extensive reconfiguration of the endosperm methylation landscape that likely reinforces transposon silencing in the embryo...
  94. pmc Regulation of expression of starch synthesis genes by ethylene and ABA in relation to the development of rice inferior and superior spikelets
    Guohui Zhu
    College of Life Sciences, South China Agricultural University, Guangdong, China
    J Exp Bot 62:3907-16. 2011
    ....
  95. pmc Mobilization of vacuolar iron by AtNRAMP3 and AtNRAMP4 is essential for seed germination on low iron
    Viviane Lanquar
    Institut des Sciences du Vegetal, CNRS, Gif sur Yvette, France
    EMBO J 24:4041-51. 2005
    ..Mutant seeds have wild type Fe content, but fail to retrieve Fe from the vacuolar globoids...
  96. pmc Variation in expression and protein localization of the PIN family of auxin efflux facilitator proteins in flavonoid mutants with altered auxin transport in Arabidopsis thaliana
    Wendy Ann Peer
    Department of Horticulture, Purdue University, West Lafayette, Indiana 47907 2010, USA
    Plant Cell 16:1898-911. 2004
    ..In some auxin-accumulating tissues, flavonoid increases and changes in flavonoid speciation are subsequent to auxin accumulation...
  97. ncbi Transcriptional regulation of ABI3- and ABA-responsive genes including RD29B and RD29A in seeds, germinating embryos, and seedlings of Arabidopsis
    Kazuo Nakashima
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, JIRCAS, 1 1 Ohwashi, Tsukuba, 305 8686, Japan
    Plant Mol Biol 60:51-68. 2006
    ..analysis using abi3 and abi5 mutants showed that ABI3 and ABI5 play important roles in the expression of RD29B in seeds. Base-substitution analysis showed that two ABREs function strongly and one ABRE coupled with DRE functions weakly ..
  98. pmc Development of maternal seed tissue in barley is mediated by regulated cell expansion and cell disintegration and coordinated with endosperm growth
    Volodymyr Radchuk
    Leibniz Institut für Pflanzengenetik und Kulturpflanzenforschung, Corrensstraße 3, D 06466 Gatersleben, Germany
    J Exp Bot 62:1217-27. 2011
    ..Possible functions of PCD in the maternal tissues imply a potential nutritive role or the relief of a physical restraint for endosperm growth. PCD could also activate post-phloem transport functions...
  99. ncbi Iron accumulation does not parallel the high expression level of ferritin in transgenic rice seeds
    Le Qing Qu
    Laboratory of Genetic Engineering, Department of Plant Biotechnology, National Institute of Agrobiological Sciences, Kannondai 2 1 2, Tsukuba, Ibaraki 305 8602, Japan
    Planta 222:225-33. 2005
    To answer the question whether iron accumulation in transgenic rice seeds depends on the expression level of exogenous soybean ferritin, we generated two kinds of ferritin hyper-expressing rice lines by introducing soybean ferritin ..
  100. ncbi A phenylalanine in DGAT is a key determinant of oil content and composition in maize
    Peizhong Zheng
    Pioneer Hi Bred International Inc, A DuPont Company, 7300 NW 62nd Avenue, PO Box 1004, Johnston, Iowa 50131, USA
    Nat Genet 40:367-72. 2008
    ..This work provides insights into the molecular basis of natural variation of oil and oleic-acid contents in plants and highlights DGAT as a promising target for increasing oil and oleic-acid contents in other crops...
  101. pmc High temperature-induced abscisic acid biosynthesis and its role in the inhibition of gibberellin action in Arabidopsis seeds
    Shigeo Toh
    Department of Life Sciences, School of Agriculture, Meiji University, Kawasaki, Kanagawa, Japan
    Plant Physiol 146:1368-85. 2008
    ..Here, we show that ABA levels in imbibed seeds are elevated at high temperature and that this increase is correlated with up-regulation of the zeaxanthin ..

Research Grants68

  1. Recombinant Attenuated Salmonella Vaccines for Humans
    Roy Curtiss; Fiscal Year: 2012
    ..We will also develop our Master File, prepare and fully characterize candidate vaccine Master Seeds for stability and safety, prepare and submit protocols for IRB approvals, submit information necessary to obtain ..
  2. Salmonella Vaccines Against Bacterial Enteropathogens
    Roy Curtiss; Fiscal Year: 2013
    ..We will annually amend our Master File, prepare and fully characterize candidate vaccine Master Seeds for stability and safety, prepare and submit protocols for IRB approvals, and submit information to facilitate ..
  3. High affinity capturing agents for strychnine
    Kit S Lam; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Strychnine is a poisonous indole alkaloid isolated from the seeds of the Indian tree Strychnos nux vomica...
  4. Recombinant life attenuated vaccine against Argentine hemorrhagic fever
    Slobodan Paessler; Fiscal Year: 2013
    ..This advance has provided us with the unique opportunity to generate a genetically well-defined seeds of Candid1 (rJUNV/Candid1cSD) and Romero (rJUNV/Romero) strains of JUNV to be utilized in immunogenicity and ..
  5. Quercitrin functions as an antioxidant and protects UV-induced carcinogenesis
    Zhuo Zhang; Fiscal Year: 2012
    ..is a glycosylated form of flavonoid compounds, widely distributed in nature, and is ubiquitous in plants, fruits, seeds, and vegetables...
  6. cGMP manufacturing of PBI-220, a broad spectrum immunoadhesin therapeutic against
    LLOYD M YU; Fiscal Year: 2013
    ..which will describe, through written procedures (SOP), all production steps from the deployment of tobacco seeds to the shipping of product...
  7. Strategies for Heavy Metal Detoxification
    Gerard Parkin; Fiscal Year: 2013
    ..use of organomercurials as pesticides resulted in the death of ca 500 people in Iraq in the early 1970s when wheat seeds treated with these pesticides were used for making bread rather than for growing wheat...
  8. Crossing Borders: HIV and Substance use at the Gateway to North America
    Kimberly C Brouwer; Fiscal Year: 2013
    ..substance using FSWs;Round 2 will focus on the MSM population;and Round 3 will begin with peer recruiters ("seeds") drawn from "mobile" persons- including truck drivers, deportees and regional and international migrants...
  9. Proteogenomics of dysregulated protein interaction networks in MTB infection
    Mark R Chance; Fiscal Year: 2013
    ..The general hypothesis of this proposal is that proteomic seeds identify sub-networks of proteins that differentiate persons at different stages of MTB infection and disease, and ..
  10. A New Point of Use Decontamination Method for Fresh Produce
    ADRIAN J DENVIR; Fiscal Year: 2010
    ..Produce related outbreaks of foodborne illness have been attributed to sprouted seeds, leafy vegetables, tomatoes, melons, berries, and unpasteurized juices...
  11. New biomonitoring methodologies to measure DNA adducts in human tissues
    Robert J Turesky; Fiscal Year: 2013
    ..In the latter, exposure to AA involves ingestion of bread prepared from flour contaminated with seeds of Aristolochia clematitis...
  12. Recombinant Attenuated Bacterial Vaccines Against Biodefense Agents
    Roy Curtiss; Fiscal Year: 2013
    ..We will make Master Seeds of all candidate vaccines, validate their potency, safety, genetic purity and stability and amend our Master File ..
  13. A Novel Therapy for Staphylococcal Enterotoxin B Poisoning
    Kenneth J Piller; Fiscal Year: 2010
    ..Oral immunizations using soy milk formulations made from transgenic seeds expressing mutant SEB could elicit protective immunity in mice challenged with lethal doses of native toxin...
  14. Fabrication and validation of implantable MRI markers for prostate cancer treatme
    Andrew Bright; Fiscal Year: 2010
    ..Prostate brachytherapy (PB) is performed using tiny radioactive (0.1-10 mCi) titanium seeds implanted directly into the prostate gland...
  15. Clinical Development of Combination Plague/Smallpox Vaccine
    CHARALAMBOS PARTIDOS; Fiscal Year: 2011
    ..pestis V antigen (MVA/V). We propose here to manufacture GMP-quality vaccine seeds and conduct preclinical studies required for FDA approval under the Animal Rule (21 CFR, 314...
  16. Accuracy of Examining Cough Function and its Relationship to Airway Protection
    CHRISTINE M contact SAPIENZA; Fiscal Year: 2010
    ..Impaired airway clearance leads to penetration of foreign material which "seeds" the subglottic airways resulting in a high prevalence of aspiration pneumonia...
  17. Accuracy of Examining Cough Function and its Relationship to Airway Protection
    Christine M Sapienza; Fiscal Year: 2013
    ..Impaired airway clearance leads to penetration of foreign material which "seeds" the subglottic airways resulting in a high prevalence of aspiration pneumonia...
  18. Targeting HIF-1 alpha Dysfunction in Complications of Aging
    Geoffrey C Gurtner; Fiscal Year: 2013
    ..complex signaling mechanisms, ischemic tissue (the "soil") actively recruits circulating progenitor cells ("the seeds") out of the bone marrow and into the area of ischemia to initiate proliferation and differentiation of these ..
  19. Effects of Silymarin on the Metabolome
    Stephen J Polyak; Fiscal Year: 2013
    ..a new collaboration that will characterize the metabolomic response to silymarin (SM), an extract of milk thistle seeds, which prevents liver injury and disease progression in many animal models, and also blocks hepatitis C virus (HCV)..
  20. Prostate Edema in Permanent Interstitial Brachytherapy
    Zhe Chen; Fiscal Year: 2010
    ..Public Health Relevance: Permanent implantation of radioactive seeds containing iodine-125, palladium-103, or cesium-131 in the prostate, also called brachytherapy, has become a ..
  21. Mosquito Vector Control Using Bt Coupled to Seed Oil Bodies
    Mohd Amir Abdullah; Fiscal Year: 2009
    ..This Phase I application will test this hypothesis by coupling Bti and BtB to oleosins in the oil-rich seeds of Arabidopsis thaliana...
  22. Prostate Cancer In Vivo Using an Ultra Low Field MRI Device
    CHARLIE DANAHER; Fiscal Year: 2010
    ..of the location of tumors to guide biopsy;and 4) in situ monitoring of focal therapies, such as placement of the seeds during brachytherapy...
  23. Do Parental Conflict and Genomic Imprinting Cause Hybrid Lethality in Mimulus?
    Elen Oneal; Fiscal Year: 2011
    ..this project will examine whether maternal and paternal copies of genes are expressed at different levels in seeds, and whether abnormal expression patterns correlate with seed lethality...
  24. Prostate Cancer Prevention and Treatment by Silibinin
    Rajesh Agarwal; Fiscal Year: 2013
    ..In this regard, silibinin, isolated from the seeds of milk thistle (Silybum marianum), has shown promising anti-cancer effects in a number of cell culture and in ..
  25. Biology of Melanoma Metastasis
    MEENHARD FOLKENS HERLYN; Fiscal Year: 2013
    ..melanoma cells leads to a decrease in metastases, suggesting JARID1B-positive cells to be potential 'seeds'for tumor maintenance...
  26. Attenuated Live and Recombinant Yersinia pestis Vaccines
    Roy Curtiss; Fiscal Year: 2013
    ..safety, efficacy and immunogenicity features and provide data to secure an IND license from the FDA, make Master Seeds and validate their stability...
  27. Proteases in Spinal Cord Plasticity &Regeneration
    Nicholas W Seeds; Fiscal Year: 2010
    ..2R01 NS044129-06A2 Seeds, Nicholas
  28. Proanthocyanidins,Novel bioactive components for prevention of melanoma invasion
    Santosh Kumar Katiyar; Fiscal Year: 2013
    ..Proanthocyanidins, which are highly enriched in grape seeds, have anti-skin carcinogenic effects in mouse models, but their effects on metastasis have not been explored...
  29. High Throughput Technology for Assessing Global DSB Repair Capacity
    DAVID JONATHAN BRENNER; Fiscal Year: 2012
    ..and on a one- by-one sequential basis, the irradiator can be very compact, so low-activity 90Sr/90Y radioactive seeds can be used...
  30. Compounds blocking crystallin aggregation in vitro;path to anti-cataract agents
    JONATHAN ALAN KING; Fiscal Year: 2013
    ..In addition, fragments of human cataractous aggregates from surgical procedures will be used as seeds in the in vitro reaction, and screened for compounds that inhibit addition of crystallin chains to the seeds...
  31. Low cost production of rabies virus antigens in rice grain
    Ning Huang; Fiscal Year: 2011
    ..Using the constructed genes, we will develop transgenic rice plants to obtain transgenic seeds. After confirmed by viral glycoprotein expression analysis, devitalized transgenic rice grain will be fed in a ..
  32. Integrated Photoacoustic Ultrasound Real-time Imaging for Brachytherapy Treatment
    Everette C Burdette; Fiscal Year: 2013
    ..Permanent interstitial brachytherapy, the permanent placement of radioactive seeds in the prostate, is widely used in the treatment of prostate cancer...
  33. Transposons, RNA Interference and Heterochromatin
    Robert A Martienssen; Fiscal Year: 2013
    ..cell specification has profound implications for plant reproduction, including the production of clonal unreduced seeds (apomixis)...
  34. Integrated approaches to deriving predictive networks from public data sources
    John Quackenbush; Fiscal Year: 2010
    ..published literature, as well as from other sources, and to use that information to develop preliminary network "seeds" that can jump-start the process of building predictive network models...
  35. HIV and Substance Abuse Epidemiology among IDUs: Structural and Network Risk Fact
    ABBY ELISE RUDOLPH; Fiscal Year: 2013
    ..Sixteen "seeds" from 8 different colonias in Tijuana, Mexico will be selected from those recently enrolled in El Cuete to ..
  36. S. typhimiurium Vaccine Against Bacterial Enteropathogens
    Roy Curtiss; Fiscal Year: 2007
    ..will also collaboratively work to develop our Master File, prepare and fully characterize candidate vaccine Master Seeds for stability and safety, prepare and submit protocols for IRB approvals, submit information necessary to obtain ..
  37. Improved diagnostic and monitoring assays for thyroid cancer
    Kenneth J Piller; Fiscal Year: 2010
    ..problems plaguing FDA-approved thyroglobulin immunoassays by expressing human thyroglobulin in transgenic soybean seeds for use as a class II medical device analyte...
  38. Multimodal Imaging of Executive and Reward Networks Across the Psychosis Spectrum
    KATHERINE HELEN KARLSGODT; Fiscal Year: 2013
    ..Task-based regions of interes (ROIs) will be used as seeds for diffusion tensor imaging tractography and as ROIs in which to probe grey matter (GM) thickness...
  39. Consortium to Evaluate a Novel Violence Prevention Program on College Campuses
    Corrine M Williams; Fiscal Year: 2013
    ..a six to either hour bystander intervention training called Students Educating and Empowering to Develop Safety (SEEDS)...
  40. Childhood Predictors of Airway Structure, Function, and Disease in Adult Life
    Anne L Wright; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): It has become clear that the seeds of many adult diseases are sown in childhood...
  41. Online Respondent-Driven Sampling &Data Collection for Men who have Sex with Men
    EDWARD WILLIAM WHITE; Fiscal Year: 2012
    ..employ respondent-driven sampling (RDS) a chain-referral method that starts by selecting of initial respondents (seeds) who recruit peers (other members of the target population) as additional respondents...
  42. Functional Connectivity in Premanifest Huntington's Disease
    STEPHEN MARK RAO; Fiscal Year: 2013
    ..The main hypothesis is that connectivity strength of seeds will be progressively weakened as prHD individuals approach diagnosis...
  43. Formative research to understand high-risk community sex networks
    Chyvette T Williams; Fiscal Year: 2010
    ..These eligible members from Stage 1 will serve as seeds in an RDS chain...
  44. Medulloblastoma and Metastases
    William A Weiss; Fiscal Year: 2013
    ..Dissemination (metastasis) of MB through the cerebrospinal fluid seeds the leptomeningeal membranes that cover the brain and spinal cord...
  45. OTHER FUNCTIONS "DEVELOPMENT OF A UNI-DIRECTIONAL BRACHYTHERAPY DEVICE FOR THE T
    KRISTY PEREZ; Fiscal Year: 2012
    ..At present, brachytherapy devices used for lung cancer treatment consist of metal I-125 or Cs-131 seeds, originally designed for prostate cancer, sewn to a bio-absorbable vicryl mesh...
  46. Radioactive Stents for Brachytherapy of Esophageal Cancers
    YONGREN BENJAMIN PENG; Fiscal Year: 2013
    ..China and Korea), there have been reported clinical benefits of attaching sealed sources such as prostate seeds to the outside of an esophageal stent...
  47. Functional and Molecular Analysis of Scout Cell Awakening
    SLAVA SIMON EPSTEIN; Fiscal Year: 2013
    ..proposed that dormancy exit is not a response to environmental cues, a characteristic of microbial spores, resting seeds of plants, hibernating animals, among others, but a low frequency, epigenetic, noise-driven, and stochastic ..
  48. Small molecule inhibitors of ricin and shiga toxins
    Jon D Robertus; Fiscal Year: 2011
    Ricin is a potent class B protein toxin found in castor seeds. Its ease of preparation has made it a favorite agent for domestic and international terrorists...
  49. Pathogenicity of prion protein aggregates from uninfected cells and brains
    Wen Quan Zou; Fiscal Year: 2013
    ..Although the conversion of PrPC into PrPSc is known to be triggered by exogenous PrPSc seeds in the infectious prion disease, how it takes place in the spontaneous prion diseases, including sporadic and ..
  50. Cellular trafficking of pathogenic Abeta seeds in vitro and in vivo
    Lary C Walker; Fiscal Year: 2012
    ..Preliminary data implicate mononuclear phagocytes (macrophages) as the vectors of the seeds, in that A[unreadable]-seed- laden macrophages enter the circulation following the intraperitoneal injection of ..
  51. INTRACAVITARY HYPERTHERM & RADIATN OF ESOPHAGEAL CANCER
    C Chou; Fiscal Year: 1993
    ..esophageal multilumen polyurethane tube, which can accommodate six channels of temperature sensors or radiation seeds at the periphery, and a microwave antenna in the center of the tube...
  52. MR Image Guided Gynecologic Brachytherapy
    Akila Viswanathan; Fiscal Year: 2013
    ..The use of brachytherapy, the placement of radioactive seeds directly into the center of the tumor, after external beam radiation, permits dose escalation to the tumor, ..
  53. FASEB SRC on TGF beta Superfamily: Signaling in Development and Disease
    MICHAEL BRENDAN O'CONNOR; Fiscal Year: 2013
    ..Intimately intertwined is also the third objective of creating the informal and creative forum that continuously seeds the fertile soil for building national and international collaborations, especially between experts working on ..
  54. Walnuts vs. Walnut-Oil, Glucose Homeostasis, PCOS
    Sidika Kasim Karakas; Fiscal Year: 2007
    ..improves insulin sensitivity, these women are advised to increase polyunsaturated fat (PUFA) intake from nuts, seeds and fish-oil. This advice is not evidence based...
  55. Cellular trafficking of B-amyloid seeds
    AMARALLYS FRANCESCA CINTRON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cellular trafficking of amyloid seeds and the instigation of Alzheimer-like pathology in a transgenic mouse model The aggregation and intracerebral accumulation of beta-amyloid (A[unreadable]) is the ..
  56. Conformation and Dynamics of Cataract Mutants of human gammaD crystallin
    Angela M Gronenborn; Fiscal Year: 2013
    ..In particular, we will establish whether such partially folded intermediates are seeds for aggregation...
  57. Share2Quit: Web-based Peer-driven Referrals for Smoking Cessation
    Rajani Shankar Sadasivam; Fiscal Year: 2013
    ..The intervention will start with an initial set of seeds and we estimate a sample of 800-1200 smokers...
  58. Echinacea: Standardized Product & Supply Provision
    Xiping Wang; Fiscal Year: 2004
    ..The source of crude material for subsequent analytical chemistry testing will be first addressed: Echinacea seeds will be tested and identified for purity, then germinated and cultivated at different seasons/soil/field ..
  59. Linking pathways and function in anxious adolescents
    YOUNGSUN T CHO; Fiscal Year: 2012
    ..We will then use these anatomic results to create seeds for regions of interest in a connectivity analysis of the pre- frontal cortex, amygdala and striatum in human ..
  60. Structural Heterogeneity and Covalent Changes in Beta Amyloid Fibrils
    Stephen C Meredith; Fiscal Year: 2010
    ..we will examine wild type A131-40 fibrils made by cross-seeding, using D23N-AI3 and ~E22-AI3 fibrils as seeds. In all of these cases, results will be compared with data obtained previously and new data on brain-seeded AI3 ..
  61. Building an Infrastructure for Research Collaborations
    Erin L Dolan; Fiscal Year: 2011
    ..Scientists provide seeds from wild-type (with all functional genes) and mutant (with a disabled gene) Arabidopsis thaliana plants, and ..
  62. Building an Infrastructure for Research Collaborations
    Erin L Dolan; Fiscal Year: 2013
    ..Scientists provide seeds from wild-type (with all functional genes) and mutant (with a disabled gene) Arabidopsis thaliana plants, and ..
  63. Ferritin and Iron Nutrition in Health and Disease
    Elizabeth Theil; Fiscal Year: 2005
    ..Ferritin is a major source of iron in the early development of humans, other animals and plants. Legume seeds consumed by humans are rich in iron and ferritin...
  64. Visualization and real-time dosimetry for prostate brachytherapy using ultrasound
    Septimiu Salcudean; Fiscal Year: 2007
    ..This treatment involves the permanent placement of radioactive capsules (seeds) in the prostate, in a pattern that delivers a sufficient radiation dose to kill the cancer while maintaining a ..
  65. Geography, networks, and risk in disease transmission
    Richard Rothenberg; Fiscal Year: 2009
    ..We will use ethnographic methods to identify 3 "seeds" in each of 5 high-burden and 5 low-burden zip codes, and will use a chain-link design to construct 30 networks of ..
  66. Pre-clinical Studies on Lupinus termis Seeds Extract
    MIKHAIL ANTOUN; Fiscal Year: 2003
    ..is intended to carry out preliminary pharmacology-toxicology studies on an alcoholic extract obtained form the seeds of a plant which, in earlier clinical studies performed outside the US, demonstrated encouraging activity in the ..
  67. BREAST CANCER RISK--VEGETABLES AND SERUM PHYTOSTEROLS
    Paola Muti; Fiscal Year: 2000
    ..Phytosterols are abundant in fat soluble fractions of plants: seeds, nuts, cereals, beans, and legumes are rich sources of phytosterols...
  68. Gamma Ray Spectroscopy for Dose Rate Constants
    Ravinder Nath; Fiscal Year: 2006
    Permanent implantation of either iodine-125 seeds or palladium-103 radioactive seeds in the prostate has become a popular form of radiation therapy for carefully selected prostate cancer patients...