quality control

Summary

Summary: A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)

Top Publications

  1. pmc The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
    Leming Shi
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA
    Nat Biotechnol 28:827-38. 2010
  2. pmc Quality control and preprocessing of metagenomic datasets
    Robert Schmieder
    Department of Computer Science, Computational Science Research Center, San Diego State University, San Diego, CA 92182, USA
    Bioinformatics 27:863-4. 2011
  3. pmc The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews
    Penny Whiting
    Centre for Reviews and Dissemination, University of York, England, UK
    BMC Med Res Methodol 3:25. 2003
  4. pmc NGS QC Toolkit: a toolkit for quality control of next generation sequencing data
    Ravi K Patel
    Functional Genomics and Bioinformatics Laboratory, National Institute of Plant Genome Research NIPGR, New Delhi, India
    PLoS ONE 7:e30619. 2012
  5. ncbi A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    B M Bolstad
    Group in Biostatistics, University of California, Berkeley, CA 94720, USA
    Bioinformatics 19:185-93. 2003
  6. ncbi RSeQC: quality control of RNA-seq experiments
    Liguo Wang
    Division of Biostatistics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Bioinformatics 28:2184-5. 2012
  7. ncbi Empirical studies assessing the quality of health information for consumers on the world wide web: a systematic review
    Gunther Eysenbach
    Centre for Global eHealth Innovation, Toronto General Hospital, 190 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    JAMA 287:2691-700. 2002
  8. ncbi Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors
    Pamela Nicholson
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland
    Cell Mol Life Sci 67:677-700. 2010
  9. pmc Genome wide association studies for milk production traits in Chinese Holstein population
    Li Jiang
    Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 5:e13661. 2010
  10. pmc Data quality control in genetic case-control association studies
    Carl A Anderson
    Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Protoc 5:1564-73. 2010

Research Grants

Detail Information

Publications368 found, 100 shown here

  1. pmc The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
    Leming Shi
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA
    Nat Biotechnol 28:827-38. 2010
    ..The conclusions and recommendations from MAQC-II should be useful for regulatory agencies, study committees and independent investigators that evaluate methods for global gene expression analysis...
  2. pmc Quality control and preprocessing of metagenomic datasets
    Robert Schmieder
    Department of Computer Science, Computational Science Research Center, San Diego State University, San Diego, CA 92182, USA
    Bioinformatics 27:863-4. 2011
    Here, we present PRINSEQ for easy and rapid quality control and data preprocessing of genomic and metagenomic datasets...
  3. pmc The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews
    Penny Whiting
    Centre for Reviews and Dissemination, University of York, England, UK
    BMC Med Res Methodol 3:25. 2003
    ..The aim of this project was to combine empirical evidence and expert opinion in a formal consensus method to develop a tool to be used in systematic reviews to assess the quality of primary studies of diagnostic accuracy...
  4. pmc NGS QC Toolkit: a toolkit for quality control of next generation sequencing data
    Ravi K Patel
    Functional Genomics and Bioinformatics Laboratory, National Institute of Plant Genome Research NIPGR, New Delhi, India
    PLoS ONE 7:e30619. 2012
    ..However, quality control (QC) of sequence data generated from these technologies is extremely important for meaningful downstream ..
  5. ncbi A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    B M Bolstad
    Group in Biostatistics, University of California, Berkeley, CA 94720, USA
    Bioinformatics 19:185-93. 2003
    ..Normalization is a process for reducing this variation. It is common to see non-linear relations between arrays and the standard normalization provided by Affymetrix does not perform well in these situations...
  6. ncbi RSeQC: quality control of RNA-seq experiments
    Liguo Wang
    Division of Biostatistics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Bioinformatics 28:2184-5. 2012
    RNA-seq has been extensively used for transcriptome study. Quality control (QC) is critical to ensure that RNA-seq data are of high quality and suitable for subsequent analyses...
  7. ncbi Empirical studies assessing the quality of health information for consumers on the world wide web: a systematic review
    Gunther Eysenbach
    Centre for Global eHealth Innovation, Toronto General Hospital, 190 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    JAMA 287:2691-700. 2002
    ..The quality of consumer health information on the World Wide Web is an important issue for medicine, but to date no systematic and comprehensive synthesis of the methods and evidence has been performed...
  8. ncbi Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors
    Pamela Nicholson
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland
    Cell Mol Life Sci 67:677-700. 2010
    ..However, as we review here, NMD is far from being a simple quality control mechanism; it also regulates the stability of many wild-type transcripts...
  9. pmc Genome wide association studies for milk production traits in Chinese Holstein population
    Li Jiang
    Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 5:e13661. 2010
    ....
  10. pmc Data quality control in genetic case-control association studies
    Carl A Anderson
    Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Protoc 5:1564-73. 2010
    ..Issues concerning study design and marker selection in case-control studies have been discussed in our earlier protocols. This protocol, which is routinely used in our labs, should take approximately 8 h to complete...
  11. pmc The RIN: an RNA integrity number for assigning integrity values to RNA measurements
    Andreas Schroeder
    Agilent Technologies, Hewlett Packard Strasse 8, 76337 Waldbronn, Germany
    BMC Mol Biol 7:3. 2006
    ..The advent of microcapillary electrophoretic RNA separation provides the basis for an automated high-throughput approach, in order to estimate the integrity of RNA samples in an unambiguous way...
  12. pmc Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies
    Daniah Trabzuni
    Reta Lilla Weston Laboratories and Departments of Molecular Neuroscience, UCL Institute of Neurology, London, UK
    J Neurochem 119:275-82. 2011
    ..We assessed the accuracy of the array data using QuantiGene, as an independent non-PCR-based method. These quality control parameters will allow database users to assess data accuracy...
  13. pmc Principles of cotranslational ubiquitination and quality control at the ribosome
    Stefanie Duttler
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Mol Cell 50:379-93. 2013
    ..The extent to which nascent chains are subject to cotranslational quality control and degradation remains unclear...
  14. pmc Evaluation of QUADAS, a tool for the quality assessment of diagnostic accuracy studies
    Penny F Whiting
    MRC Health Services Research Collaboration, Department of Social Medicine, Canynge Hall, Whiteladies Road, Bristol, UK
    BMC Med Res Methodol 6:9. 2006
    ..Although QUADAS has been used in several systematic reviews, it has not been formally validated. The objective was to evaluate the validity and usefulness of QUADAS...
  15. ncbi Comparative proteomic analysis identifies a role for SUMO in protein quality control
    Michael H Tatham
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Sci Signal 4:rs4. 2011
    ..Together, these findings suggest multiple, proteasome-independent roles for SUMOs in the cellular response to the accumulation of misfolded proteins...
  16. pmc The relationship of previous training and experience of journal peer reviewers to subsequent review quality
    Michael L Callaham
    Division of Emergency Medicine, University of California, San Francisco, United States of America
    PLoS Med 4:e40. 2007
    ..More objective selection of peer reviewers might improve the journal peer review process and thus the quality of published science...
  17. pmc Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin
    Francisca E Reyes-Turcu
    Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Struct Mol Biol 18:1132-8. 2011
    ..We show that cells lacking Mlo3, a protein involved in mRNP biogenesis and RNA quality control, assemble functional heterochromatin in RNAi-deficient cells...
  18. ncbi Does the CONSORT checklist improve the quality of reports of randomised controlled trials? A systematic review
    Amy C Plint
    Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada
    Med J Aust 185:263-7. 2006
    ..To determine whether the adoption of the CONSORT checklist is associated with improvement in the quality of reporting of randomised controlled trials (RCTs)...
  19. ncbi Measuring and interpreting point spread functions to determine confocal microscope resolution and ensure quality control
    Richard W Cole
    Wadsworth Center, New York State Department of Health, Albany, New York, USA
    Nat Protoc 6:1929-41. 2011
    ..The microsphere sample preparation requires 2-3 h plus an overnight drying period. The microscope setup requires 2 h (1 h for laser warm up), whereas collecting and analyzing the PSF images require an additional 2-3 h...
  20. pmc Quality control mechanisms during ribosome maturation
    Katrin Karbstein
    Department of Cancer Biology, The Scripps Research Institute, 130 Scripps Way 2C2, Jupiter, FL 33458, USA
    Trends Cell Biol 23:242-50. 2013
    ..Together, these findings suggest that quality control mechanisms must be in place to survey nascent ribosomes and ensure their functionality...
  21. pmc The retrograde response: when mitochondrial quality control is not enough
    S Michal Jazwinski
    Tulane Center for Aging and Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Biochim Biophys Acta 1833:400-9. 2013
    ..Thus, continued mitochondrial activity requires maintenance. There are numerous means by which this quality control is ensured. Autophagy and selective mitophagy are among them...
  22. ncbi Adjustment of systematic microarray data biases
    Monica Benito
    Department of Statistics and Econometrics, University of Carlos III, Madrid, Spain
    Bioinformatics 20:105-14. 2004
    ..These systematic effects present a substantial hurdle to the analysis of microarray data...
  23. ncbi Quality control and data reduction procedures for accelerometry-derived measures of physical activity
    Rachel Colley
    Children s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario
    Health Rep 21:63-9. 2010
    This article describes four key quality control and data reduction issues that researchers should consider when using accelerometry to measure physical activity: monitor reliability, spurious data, monitor wear time, and number of valid ..
  24. ncbi Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses
    L L Kjaergard
    Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshospitalet, DK 2100 Copenhagen, Denmark
    Ann Intern Med 135:982-9. 2001
    ..To explore whether reported methodologic quality affects estimated intervention effects in randomized trials and contributes to discrepancies between the results of large randomized trials and small randomized trials in meta-analyses...
  25. pmc The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Molndal, Sweden
    Alzheimers Dement 7:386-395.e6. 2011
    ..The Alzheimer's Association has initiated a global quality control program to estimate and monitor variability of measurements, quantify batch-to-batch assay variations, and ..
  26. pmc Selectome update: quality control and computational improvements to a database of positive selection
    Sebastien Moretti
    Department of Ecology and Evolution, Biophore, University of Lausanne, CH 1015 Lausanne, Switzerland, Evolutionary Bioinformatics Group, SIB Swiss Institute of Bioinformatics, CH 1015 Lausanne, Switzerland, Vital IT Group, SIB Swiss Institute of Bioinformatics, CH 1015 Lausanne, Switzerland, Computational Phylogenetics group, SIB Swiss Institute of Bioinformatics, CH 1015 Lausanne, Switzerland, Division of Biosciences, Institute of Structural and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK and Swiss National Supercomputing Centre CSCS, CH 6900, Lugano, Switzerland
    Nucleic Acids Res 42:D917-21. 2014
    ..Since the original release of Selectome, we have benchmarked and implemented a thorough quality control procedure on multiple sequence alignments, aiming to provide minimum false-positive results...
  27. ncbi No-go decay: a quality control mechanism for RNA in translation
    Yuriko Harigaya
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721 0106, USA
    Wiley Interdiscip Rev RNA 1:132-41. 2010
    Eukaryotic cells have evolved multiple quality control mechanisms that recognize and eliminate defective mRNA during the process of translation...
  28. pmc Data exploration, quality control and testing in single-cell qPCR-based gene expression experiments
    Andrew McDavid
    Department of Statistics, University of Washington, Seattle, WA 98195, USA
    Bioinformatics 29:461-7. 2013
    ..However, few analytic tools have been developed specifically for the statistical and analytical challenges of single-cell quantitative polymerase chain reactions data...
  29. ncbi Reporting of noninferiority and equivalence randomized trials: an extension of the CONSORT statement
    Gilda Piaggio
    Statistics and Informatics Services Group, Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland
    JAMA 295:1152-60. 2006
    ..The intent is to improve reporting of noninferiority and equivalence trials, enabling readers to assess the validity of their results and conclusions...
  30. pmc Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality
    Rebecca L Zuvich
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA
    Genet Epidemiol 35:887-98. 2011
    ..In all, approximately 17,000 samples from across the five sites were genotyped. A unified quality control (QC) pipeline was developed by the eMERGE Genomics Working Group and used to ensure thorough cleaning of the ..
  31. pmc Randomized trials published in some Chinese journals: how many are randomized?
    Taixiang Wu
    Chinese Cochrane Centre, Chinese Evidence Based Medicine Centre, International Clinical Epidemiology Network INCLEN, West China Hospital, Sichuan University, Chengdu, PR China
    Trials 10:46. 2009
    ..We investigated the adequacy of randomization of clinical trials published in recent years in China to determine how many of them met acceptable standards for allocating participants to treatment groups...
  32. pmc RNA-SeQC: RNA-seq metrics for quality control and process optimization
    David S DeLuca
    Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Bioinformatics 28:1530-2. 2012
    ..In summary, RNA-SeQC provides quality control measures critical to experiment design, process optimization and downstream computational analysis.
  33. ncbi Completeness of safety reporting in randomized trials: an evaluation of 7 medical areas
    J P Ioannidis
    Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    JAMA 285:437-43. 2001
    ..Current standards for safety reporting in randomized trials should be revised to address this inadequacy...
  34. pmc Methods and dimensions of electronic health record data quality assessment: enabling reuse for clinical research
    Nicole Gray Weiskopf
    Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA
    J Am Med Inform Assoc 20:144-51. 2013
    ..To review the methods and dimensions of data quality assessment in the context of electronic health record (EHR) data reuse for research...
  35. pmc Quality control and quality assurance in genotypic data for genome-wide association studies
    Cathy C Laurie
    Department of Biostatistics, University of Washington, Seattle, Washington, USA
    Genet Epidemiol 34:591-602. 2010
    ..attention to data quality has been appreciated for some time in this field, and a number of strategies for quality control and quality assurance (QC/QA) have been developed...
  36. ncbi Strategies for quality control of Chinese medicines
    S P Li
    State Key Laboratory for Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China
    J Pharm Biomed Anal 55:802-9. 2011
    Chinese medicines (CM) have been attracting interest and acceptance in many countries. Quality control is vital for ensuring the safety and efficacy of CM...
  37. ncbi Simpleaffy: a BioConductor package for Affymetrix Quality Control and data analysis
    Claire L Wilson
    Paterson Institute for Cancer Research, Manchester M20 4BX, UK
    Bioinformatics 21:3683-5. 2005
    b>Quality Control is a fundamental aspect of successful microarray data analysis...
  38. ncbi Improved quality control method for Fufang Danshen preparations through simultaneous determination of phenolic acids, saponins and diterpenoid quinones by HPLC coupled with diode array and evaporative light scattering detectors
    Ying Jie Wei
    Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Ministry of Education, Nanjing 210009, China
    J Pharm Biomed Anal 45:775-84. 2007
    ..by various manufacturers with the raw materials from different sources, pose a serious challenge to the quality control of this herb medicine...
  39. ncbi Statistical issues in quality control of proteomic analyses: good experimental design and planning
    David A Cairns
    Clinical and Biomedical Proteomics Group, Section of Oncology and Clinical Research, Leeds Cancer Research UK Centre, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    Proteomics 11:1037-48. 2011
    b>Quality control is becoming increasingly important in proteomic investigations as experiments become more multivariate and quantitative. Quality control applies to all stages of an investigation and statistics can play a key role...
  40. pmc Transcriptome sequencing of the Microarray Quality Control (MAQC) RNA reference samples using next generation sequencing
    Shrinivasrao P Mane
    Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA
    BMC Genomics 10:264. 2009
    ..As a preliminary evaluation of these promising technologies, we performed deep sequencing of cDNA synthesized from the Microarray Quality Control (MAQC) reference RNA samples using Roche's 454 Genome Sequencer FLX.
  41. pmc Quality control in microarray assessment of gene expression in human airway epithelium
    Tina Raman
    Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, USA
    BMC Genomics 10:493. 2009
    ..The focus of this study was to establish rigorous quality control parameters to ensure that microarray assessment of the airway epithelium is not confounded by experimental ..
  42. ncbi NORDCAN--a Nordic tool for cancer information, planning, quality control and research
    Gerda Engholm
    NORDCAN Secretariat, Department of Cancer Prevention and Documentation, Danish Cancer Society, Strandboulevarden 49, Copenhagen Ø, Denmark
    Acta Oncol 49:725-36. 2010
    ....
  43. ncbi Production, quality control, stability and pharmacotoxicity of cGMP-produced Plasmodium falciparum AMA1 FVO strain ectodomain expressed in Pichia pastoris
    Bart W Faber
    Department of Parasitology, Biomedical Primate Research Center, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
    Vaccine 26:6143-50. 2008
    ..These formulations also showed no pharmacotoxicity in rabbits. The final product conformed to preset criteria and was judged suitable for use in human clinical trials...
  44. pmc DrugBank: a comprehensive resource for in silico drug discovery and exploration
    David S Wishart
    Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E8
    Nucleic Acids Res 34:D668-72. 2006
    ..DrugBank is available at http://redpoll.pharmacy.ualberta.ca/drugbank/...
  45. pmc Cell-specific differences in the requirements for translation quality control
    Noah M Reynolds
    Department of Microbiology, Center for RNA Biology, Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 107:4063-8. 2010
    ..These striking differences reveal unexpectedly divergent requirements for quality control in different cell compartments and suggest that the limits of translational accuracy may be largely ..
  46. ncbi How to interpret a genome-wide association study
    Thomas A Pearson
    Office of Population Genomics, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 2154, USA
    JAMA 299:1335-44. 2008
    ..This article describes the design, interpretation, application, and limitations of GWA studies for clinicians and scientists for whom this evolving science may have great relevance...
  47. pmc Laboratory evolution of fast-folding green fluorescent protein using secretory pathway quality control
    Adam C Fisher
    School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 3:e2351. 2008
    ..This prompted us to hypothesize that the folding quality control inherent to this secretory pathway could be used as a platform for engineering similar 'superfolded' proteins...
  48. ncbi Nuclear quality control of RNA polymerase II transcripts
    Manfred Schmid
    Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology, Aarhus University, C F Møllers Alle, Bldg 130, 8000 Aarhus C, Denmark
    Wiley Interdiscip Rev RNA 1:474-85. 2010
    ..Cells, therefore, employ nuclear RNA quality control mechanisms to rapidly degrade, actively retain, or transcriptionally silence unwanted RNAs...
  49. pmc An R package suite for microarray meta-analysis in quality control, differentially expressed gene analysis and pathway enrichment detection
    Xingbin Wang
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Bioinformatics 28:2534-6. 2012
    ..In this article, we present MetaOmics, a suite of three R packages MetaQC, MetaDE and MetaPath, for quality control, differentially expressed gene identification and enriched pathway detection for microarray meta-analysis...
  50. pmc Posttranslational modification and quality control
    Xuejun Wang
    Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, 414 East Clark St, Vermillion, SD 57069, USA
    Circ Res 112:367-81. 2013
    Protein quality control functions to minimize the level and toxicity of misfolded proteins in the cell. Protein quality control is performed by intricate collaboration among chaperones and target protein degradation...
  51. pmc A cotranslational ubiquitination pathway for quality control of misfolded proteins
    Feng Wang
    Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Mol Cell 50:368-78. 2013
    ..These results indicate that ubiquitination of nascent polypeptides occurs in two contexts and define CTU(A) as a component of a quality control system that marks proteins for destruction while they are being synthesized.
  52. ncbi Staying cool in difficult times: mitochondrial dynamics, quality control and the stress response
    Timothy E Shutt
    University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, Canada K1Y 4W7
    Biochim Biophys Acta 1833:417-24. 2013
    ..in damage to lipids, protein and mtDNA, which must be repaired through essential pathways in mitochondrial quality control. It has long been established that intrinsic protease pathways within the matrix and intermembrane space ..
  53. pmc Improved quality control processing of peptide-centric LC-MS proteomics data
    Melissa M Matzke
    Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Bioinformatics 27:2866-72. 2011
    ..g. analysis of variance (ANOVA)] rely upon accurate estimates of sample variance, and their results are influenced by extreme values...
  54. ncbi Protein N-glycosylation along the secretory pathway: relationship to organelle topography and function, protein quality control, and cell interactions
    Jürgen Roth
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Chem Rev 102:285-303. 2002
  55. ncbi Highly parallel SNP genotyping
    J B Fan
    llumina, Inc, San Diego, California 92121, USA
    Cold Spring Harb Symp Quant Biol 68:69-78. 2003
  56. ncbi The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials
    D Moher
    University of Ottawa, Thomas C Chalmers Centre for Systematic Reviews, Ottawa, Ontario, Canada
    Lancet 357:1191-4. 2001
    ..In sum, the CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results...
  57. ncbi Quality of clinical practice guidelines in dermatological oncology
    E R M de Haas
    Department of Dermatology, Erasmus MC, Rotterdam, The Netherlands
    J Eur Acad Dermatol Venereol 21:1193-8. 2007
    ..To determine the quality of guidelines the Appraisal of Guidelines and Research and Evaluation (AGREE) instrument was developed and introduced in 2001. The AGREE instrument consists of 23 criteria, grouped in six domains...
  58. ncbi Fit-for-purpose method development and validation for successful biomarker measurement
    Jean W Lee
    Formerly MDS Pharma Services, Lincoln, Nebraska, USA
    Pharm Res 23:312-28. 2006
    ..Sample analysis within this context of fit-for-purpose method development and validation are well suited for successful biomarker implementation, allowing increased use of biomarkers in drug development...
  59. ncbi Quality control for functional magnetic resonance imaging using automated data analysis and Shewhart charting
    A Simmons
    Department of Clinical Neurosciences, Institute of Psychiatry, Maudsley Hospital, London, United Kingdom
    Magn Reson Med 41:1274-8. 1999
    A data acquisition and analysis protocol for quality control (QC) of functional magnetic resonance imaging studies is presented...
  60. ncbi Pathogenesis of ER storage disorders: modulating Russell body biogenesis by altering proximal and distal quality control
    Riccardo Ronzoni
    Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy
    Traffic 11:947-57. 2010
    ..synthesis/translocation) and exit from (secretion/degradation) ESC, and can be also a consequence of altered quality control (QC) mechanisms...
  61. pmc Quality control trial for human immunodeficiency virus type 1 drug resistance testing using clinical samples reveals problems with detecting minority species and interpretation of test results
    Klaus Korn
    Institute of Clinical and Molecular Virology, German National Reference Centre for Retroviruses, University of Erlangen Nurnberg, D 91054 Erlangen, Germany
    J Clin Microbiol 41:3559-65. 2003
    Between January and March 2000, a quality control panel for human immunodeficiency virus (HIV) drug resistance testing was analyzed by 20 laboratories in five countries...
  62. pmc Anti-malarial drug quality in Lagos and Accra - a comparison of various quality assessments
    Roger Bate
    American Enterprise Institute, Washington, D C, USA
    Malar J 9:157. 2010
    ..Since intelligence provided by investigators indicates that some counterfeit producers may be adapting products to pass Minilab tests, the results are compared with those from a Raman spectrometer and discrepancies are discussed...
  63. pmc NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins
    Kim D Pruitt
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Rm 6An 12J, 45 Center Drive, Bethesda, MD 20892 6510, USA
    Nucleic Acids Res 35:D61-5. 2007
    ..The format of all RefSeq records is validated, and an increasing number of tests are being applied to evaluate the quality of sequence and annotation, especially in the context of complete genomic sequence...
  64. ncbi Mistakes in a stat laboratory: types and frequency
    M Plebani
    Servizio di Medicina di Laboratorio, Azienda Ospedaliera di Padova, Italy
    Clin Chem 43:1348-51. 1997
    ..The promotion of quality control and continuous improvement of the total testing process, including pre- and postanalytical phases, seems to ..
  65. ncbi The quality of reporting of trial abstracts is suboptimal: survey of major general medical journals
    Otavio Berwanger
    Research Institute of Heart Hospital IEP HCor, Sao Paulo SP, Brazil
    J Clin Epidemiol 62:387-92. 2009
    ..To evaluate the quality of reporting of abstracts describing randomized controlled trials (RCTs) published in four major general medical journals...
  66. pmc Guidelines on good clinical laboratory practice: bridging operations between research and clinical research laboratories
    J Ezzelle
    PPD Inc, 929 North Front Street, Wilmington, NC 28401 3331, United States
    J Pharm Biomed Anal 46:18-29. 2008
    ....
  67. ncbi mRNA and microRNA quality control for RT-qPCR analysis
    C Becker
    Physiology Weihenstephan, Technical University Munich, Freising, Germany
    Methods 50:237-43. 2010
    ..RNA quality control may also be integrated in the routine analysis of new applications like the investigation of microRNA (miRNA) ..
  68. ncbi Reliability of malaria microscopy in epidemiological studies: results of quality control
    A H Kilian
    Basic Health Services Project, Gesellschaft für Technische Zusammenarbeit mbH GTZ, Fort Portal, Uganda
    Trop Med Int Health 5:3-8. 2000
    ..proportion of samples above various parasite density cut-off levels were almost identical in the routine and quality control readings...
  69. ncbi Current technologies for HER2 testing in breast cancer
    C B Moelans
    Department of Pathology, University Medical Center Utrecht, The Netherlands
    Crit Rev Oncol Hematol 80:380-92. 2011
    ..g. ELISA), at the RNA level (RT-PCR, microarray) and at the DNA level (fluorescence in situ hybridization, chromogenic in situ hybridization (ISH), silver in situ hybridization or multiplex ligation-dependent probe amplification)...
  70. pmc Implementation of basic quality control tests for malaria medicines in Amazon Basin countries: results for the 2005-2010 period
    Victor S Pribluda
    Promoting the Quality of Medicines Program, United States Pharmacopeia, Rockville, MD 20852, USA
    Malar J 11:202. 2012
    ....
  71. pmc Kraken: a set of tools for quality control and analysis of high-throughput sequence data
    Matthew P A Davis
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
    Methods 63:41-9. 2013
    ..Sequences can be trimmed and filtered based on length, quality and complexity. Quality control plots track sequence length, composition and summary statistics with respect to genomic annotation...
  72. ncbi Phenotypic and genetic characterization of the 2008 WHO Neisseria gonorrhoeae reference strain panel intended for global quality assurance and quality control of gonococcal antimicrobial resistance surveillance for public health purposes
    Magnus Unemo
    Department of Clinical Microbiology, Orebro University Hospital, Sweden
    J Antimicrob Chemother 63:1142-51. 2009
    ..gonorrhoeae strains used in quality control and assurance aspects of the national, WHO regional and international programmes for AMR surveillance it ..
  73. ncbi Evaluation of quality control strategies in Scutellaria herbal medicines
    Susanne P Boyle
    School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen AB10 1FR, United Kingdom
    J Pharm Biomed Anal 54:951-7. 2011
    ..It is proposed that the PAC value alone or in combination with a chromatographic fingerprint of key biomarkers [e.g. baicalin or (baicalin+baicalein)] may be useful indicators to adopt for the quality control of S. baicalensis.
  74. ncbi htSeqTools: high-throughput sequencing quality control, processing and visualization in R
    Evarist Planet
    Biostatistics and Bioinformatics Unit, Institute for Research in Biomedicine of Barcelona, Barcelona, Spain
    Bioinformatics 28:589-90. 2012
    ..It includes detection of outliers and biases, inefficient immuno-precipitation and overamplification artifacts, de novo identification of read-rich genomic regions and visualization of the location and coverage of genomic region lists...
  75. ncbi Consistent manufacturing and quality control of a highly complex recombinant polyclonal antibody product for human therapeutic use
    Torben P Frandsen
    Symphogen A S, Elektrovej Building 375, 2800 Lyngby, Denmark
    Biotechnol Bioeng 108:2171-81. 2011
    ....
  76. ncbi Quality control technique to reduce the variability of longitudinal measurement of hemoglobin mass
    C E Gough
    Department of Physiology, Australian Institute of Sport, Belconnen, Australian Capital Territory, Australia
    Scand J Med Sci Sports 21:e365-71. 2011
    ..7%. The majority of between-laboratory variation in Hb(mass) originated from the difference between hemoximeters, which could be eliminated using appropriate quality controls...
  77. pmc MetaQC: objective quality control and inclusion/exclusion criteria for genomic meta-analysis
    Dongwan D Kang
    Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Nucleic Acids Res 40:e15. 2012
    Genomic meta-analysis to combine relevant and homogeneous studies has been widely applied, but the quality control (QC) and objective inclusion/exclusion criteria have been largely overlooked...
  78. ncbi Quality control for genome-wide association studies
    Michael E Weale
    Department of Medical and Molecular Genetics, King s College London, Guy s Hospital, London, UK
    Methods Mol Biol 628:341-72. 2010
    This chapter is a comprehensive review of quality control (QC) methods for SNP-based genotyping panels used in genome-wide association studies...
  79. ncbi A pair of new statistical parameters for quality control in RNA interference high-throughput screening assays
    Xiaohua Douglas Zhang
    Biometrics Research, Merck Research Laboratories, West Point, PA 19486, USA
    Genomics 89:552-61. 2007
    ..To obtain high-quality HTS assays, there is a strong need for an easily interpretable and theoretically based quality control (QC) metric...
  80. pmc A framework for quality control and parameter optimization in diffusion tensor imaging: theoretical analysis and validation
    Khader M Hasan
    Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston Medical School, Houston, TX 77030, USA
    Magn Reson Imaging 25:1196-202. 2007
    In this communication, a theoretical framework for quality control and parameter optimization in diffusion tensor imaging (DTI) is presented and validated...
  81. pmc Sorting out the trash: the spatial nature of eukaryotic protein quality control
    Emily M Sontag
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Curr Opin Cell Biol 26:139-46. 2014
    ..Here we discuss emerging evidence that the pathways of protein quality control (PQC) are intimately linked to cell architecture, and sequester proteins into spatially and functionally ..
  82. ncbi Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program
    J Gabert
    Department of Hematology Biology, Institut Paoli Calmettes, France
    Leukemia 17:2318-57. 2003
    ..During our program, three quality control rounds on a large series of coded RNA samples were performed including a balanced randomized assay, which ..
  83. ncbi Analytical methods for quality control of propolis
    P G Pietta
    C N R, I T B, V le F lli Cervi, 93, Segrate MI, Italy
    Fitoterapia 73:S7-20. 2002
    ..Direct analysis by APCI-IT-MS represents a valuable alternative to obtain typical fingerprints of propolis and a reliable identification of a large number of propolis components...
  84. pmc Some essential considerations in the design and conduct of non-inferiority trials
    Thomas R Fleming
    Department of Biostatistics, University of Washington, Seattle, WA 98195 7232, USA
    Clin Trials 8:432-9. 2011
    ..Formally, the non-inferiority trial usually is designed to rule out a non-inferiority margin, defined as the minimum threshold for what would constitute an unacceptable loss of efficacy...
  85. ncbi TuBaFrost 2: Standardising tissue collection and quality control procedures for a European virtual frozen tissue bank network
    M M Morente
    Centro Nacional de Investigaciones Oncologicas, Melchor Fernandez Almagro, 3, E 28029 Madrid, Spain
    Eur J Cancer 42:2684-91. 2006
    ..The operational framework for TuBaFrost has drawn upon the best practice of standard workflows and operating procedures employed by members of the TuBaFrost project and key initiatives worldwide...
  86. ncbi Simultaneous quantification of 14 ginsenosides in Panax ginseng C.A. Meyer (Korean red ginseng) by HPLC-ELSD and its application to quality control
    Su Na Kim
    Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 110 460, South Korea
    J Pharm Biomed Anal 45:164-70. 2007
    ..The amounts of the 14 ginsenosides in the various ginseng samples could be analyzed simultaneously. This validated HPLC method is expected to provide a new basis for the quality assessment of ginseng products...
  87. ncbi Live cell quality control and utility of real-time cell electronic sensing for assay development
    Shelli L Kirstein
    ACEA Biosciences Inc, San Diego, CA 92121, USA
    Assay Drug Dev Technol 4:545-53. 2006
    ..that provide a quantitative account of cell behavior and can be used as a diagnostic tool for cellular quality control. The utility of the specific signature patterns was shown by demonstrating the significant differences in ..
  88. ncbi DNA yield and quality of saliva samples and suitability for large-scale epidemiological studies in children
    A C Koni
    College of Medicine, Veterinary and Life Sciences, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland, UK
    Int J Obes (Lond) 35:S113-8. 2011
    ..To evaluate two saliva collection methods for DNA yield and quality as applied to a large, integrated, multicentre, European project involving the collection of biological material from children...
  89. pmc A simple and fast two-locus quality control test to detect false positives due to batch effects in genome-wide association studies
    Sang Hong Lee
    Queensland Institute of Medical Research, Herston, Queensland, Australia
    Genet Epidemiol 34:854-62. 2010
    The impact of erroneous genotypes having passed standard quality control (QC) can be severe in genome-wide association studies, genotype imputation, and estimation of heritability and prediction of genetic risk based on single nucleotide ..
  90. ncbi Has the quality of abstracts for randomised controlled trials improved since the release of Consolidated Standards of Reporting Trial guideline for abstract reporting? A survey of four high-profile anaesthesia journals
    Ozlem S Can
    Department of Anaesthesiology and Intensive Care, Faculty of Medicine, Ankara University, Ankara, Turkey
    Eur J Anaesthesiol 28:485-92. 2011
    ..The current study assessed whether there has been an improvement in the quality of RCT abstracts published in main anaesthesia journals since this new guideline was introduced...
  91. ncbi Empirical evidence of design-related bias in studies of diagnostic tests
    J G Lijmer
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, The Netherlands
    JAMA 282:1061-6. 1999
    ..The literature contains a large number of potential biases in the evaluation of diagnostic tests. Strict application of appropriate methodological criteria would invalidate the clinical application of most study results...
  92. pmc PRIDE: quality control in a proteomics data repository
    Attila Csordas
    EMBL Outstation, European Bioinformatics Institute EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
    Database (Oxford) 2012:bas004. 2012
    ..Here, we describe the PRIDE curation pipeline and its practical application in quality control of complex data depositions. DATABASE URL: http://www.ebi.ac.uk/pride/.
  93. ncbi Identifying actives from HTS data sets: practical approaches for the selection of an appropriate HTS data-processing method and quality control review
    Tong Ying Shun
    University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA, USA
    J Biomol Screen 16:1-14. 2011
    ..Step 1 is to determine the most appropriate HTS data-processing method and establish criteria for quality control review and active identification from 3-day assay signal window and DMSO validation tests...
  94. ncbi pH measurement as quality control on human post mortem brain tissue: a study of the BrainNet Europe consortium
    C M Monoranu
    Department of Neuropathology, Institute of Pathology, University of Wurzburg, Germany
    Neuropathol Appl Neurobiol 35:329-37. 2009
    ..Here we examine the influence of several premortem and post mortem factors on pH, and discuss the role of pH as a biochemical marker for brain tissue quality...
  95. ncbi Digital slides: present status of a tool for consultation, teaching, and quality control in pathology
    Rafael Rocha
    Department of Pathology Universidade Federal de Minas Gerais, Brazil
    Pathol Res Pract 205:735-41. 2009
    ..Overcoming this major drawback may revolutionize the surgical pathologist's activity and slide storing...
  96. pmc External quality assessment for KRAS testing is needed: setup of a European program and report of the first joined regional quality assessment rounds
    Ellen Bellon
    University of Leuven, Centre for Human Genetics, Research Unit Biomedical Quality Assurance Leuven, Herestraat 49, Box 602, 3000, Leuven, Belgium
    Oncologist 16:467-78. 2011
    ..We aim to further expand this program to more laboratories to provide a robust estimate of the quality of KRAS testing in Europe, and provide the basis for remedial measures and harmonization...
  97. ncbi Quality control in the yeast secretory pathway: a misfolded PMA1 H+-ATPase reveals two checkpoints
    Thierry Ferreira
    Department of Genetics and the Center for Cell and Molecular Imaging, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 277:21027-40. 2002
    ..to the cell surface via the secretory pathway and has recently emerged as an excellent system for identifying quality control mechanisms along the pathway...
  98. ncbi Improving the quality of reporting alcohol outcome studies: effects of the CONSORT statement
    Benjamin O Ladd
    Center on Alcoholism, Substance Abuse, and Addictions CASAA, 2650 Yale Blvd SE, MSC11 6280, Albuquerque, NM 87106, USA
    Addict Behav 35:660-6. 2010
    ..Results suggest that efforts to improve reporting such as the CONSORT guidelines can be useful and influential...
  99. ncbi 111In-pentetreotide scintigraphy: procedure guidelines for tumour imaging
    Emilio Bombardieri
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Eur J Nucl Med Mol Imaging 37:1441-8. 2010
    ..The aim of this guideline is to assist nuclear medicine physicians in recommending, performing, reporting and interpreting the results of (111)In-pentetreotide scintigraphy...
  100. ncbi Recognition of errors in three-dimensional structures of proteins
    M J Sippl
    Center for Applied Molecular Engineering, University of Salzburg, Austria
    Proteins 17:355-62. 1993
    ..The techniques are even applicable in cases where only the C alpha trace of a protein conformation is available. The capabilities of the technique are demonstrated using correct and incorrect protein folds...
  101. ncbi Substandard tuberculosis drugs on the global market and their simple detection
    K F Laserson
    Division of TB Elimination, National Centers for HIV AIDS, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Int J Tuberc Lung Dis 5:448-54. 2001
    ..The prevalence of substandard anti-tuberculosis drugs is unknown. To maximize the effectiveness of tuberculosis (TB) control efforts, simple, inexpensive drug quality screening methods are needed...

Research Grants76

  1. High Throughput Genotyping and DNA Sequencing for Studying the Genetic Contributi
    Sonia Dua; Fiscal Year: 2013
    ..by the COR and/or CSO, for storage and retrieval of clinical, pedigree, genotypic, reagent, project tracking, quality control and other laboratory data...
  2. Functional Genomics of the Mitochondrial Proteome
    Dennis R Winge; Fiscal Year: 2011
    ..be a disease gene for familial paraganglioma, Vms1 a novel stress-responsive system for mitochondrial protein quality control and Coa4 which are novel assembly factors for the biogenesis of cytochrome c reductase and cytochrome oxidase,..
  3. BIOCHEMISTRY OF PRE-MRNA SPLICING
    Adrian R Krainer; Fiscal Year: 2010
    ..The proposed studies are aimed at understanding basic cellular mechanisms of gene expression, and may provide the basis for developing or improving diagnostic tools and therapeutic agents for these diseases. ..
  4. Latin American Center for Malaria Research and Control
    SOCRATES HERRERA VALENCIA; Fiscal Year: 2013
    ..The study team will provide technical assistance for helping NMCPs improve surveillance operations, including quality control and assurance of data with respect to diagnostics...
  5. A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2012
    ..5. To develop the tools and infrastructure for data management, quality control, and research oversight. 6. To develop a data and safety monitoring plan...
  6. Respiration in Sepsis
    Claude A Piantadosi; Fiscal Year: 2013
    ..Understanding these fundamental regulatory mechanisms is needed to design forward-thinking therapeutic approaches to protect mitochondrial quality control during sepsis.
  7. MOUSE MODEL FOR DISEASES OF PROTEIN MISFOLDING
    P Michael Conn; Fiscal Year: 2012
    ..Misfolded mutant proteins are detected by the cellular quality control system (QCS) and are typically retained in the endoplasmic reticulum (ER) for either reprocessing or ..
  8. Characterization of the ER associated Biogenesis and Degradation of ENaC
    Teresa M Buck; Fiscal Year: 2013
    ..compartments has been extensively studied, there is currently little known about ENaC biosynthesis and quality control in the ER...
  9. Central Biochemistry Laboratory of the CKiD Consortium
    George J Schwartz; Fiscal Year: 2013
    ..odd number visits at which no iohexol study is performed, maintain the Manual of Procedures, assure the quality control of all assays, and provide continuity of biochemical assays through changes in instrumentation...
  10. Delivery of Polyphenols in Gum for Treatment of Gingivitis
    Craig S Miller; Fiscal Year: 2013
    ..A cGMP batch will be manufactured and Quality Control testing and Quality Assurance release will be performed...
  11. Identification of Inhibitors that Stabilize ER Degradation Substrates
    Domenico Tortorella; Fiscal Year: 2012
    ..by applicant): Newly synthesized endoplasmic reticulum (ER) proteins are subjected to inspection by the ER quality control machinery to ensure that only properly folded molecules can traffic to their final destination...
  12. North Carolina Birth Defects Study To Evaluate Pregnancy Exposures (NC BD-STEPS)
    Andrew Olshan; Fiscal Year: 2013
    ..including epidemiology, biostatistics, method development and pilot design, genetics, study conduct, and quality control for interviewing and laboratory procedures...
  13. CARDIA Echocardiography Reading Center
    Joao A C Lima; Fiscal Year: 2012
    ..outstanding database and specimen bank, and team of investigators, organizational structure, and quality control procedures...
  14. Defining the role of proteostasis pathways in cancer drug resistance
    ERICA LYNN CAIN; Fiscal Year: 2013
    ..following aims: 1) Characterize the dependence and effects of BRCA2 revertant protein expression on protein quality control and stress response pathways...
  15. CARDIA
    Sharina D Person; Fiscal Year: 2010
    ..outstanding database and specimen bank, and team of investigators, organizational structure, and quality control procedures...
  16. CARDIA ECHO RC
    Joao Lima; Fiscal Year: 2010
    ..outstanding database and specimen bank, and team of investigators, organizational structure, and quality control procedures...
  17. CARDIA
    O Dale Williams; Fiscal Year: 2011
    ..outstanding database and specimen bank, and team of investigators, organizational structure, and quality control procedures...
  18. CARDIA ECHO RC
    Joao A C Lima; Fiscal Year: 2011
    ..outstanding database and specimen bank, and team of investigators, organizational structure, and quality control procedures...
  19. CARDIA ECHO RC CAN 9-8470189
    Joao Lima; Fiscal Year: 2009
    ..outstanding database and specimen bank, and team of investigators, organizational structure, and quality control procedures...
  20. Coronary Artery Risk Development in Young Adults (CARDIA) Study - CC
    James Shikany; Fiscal Year: 2012
    ..outstanding database and specimen bank, and team of investigators, organizational structure, and quality control procedures...
  21. Mitochondrial chaperones mortalin and Tid1 in protein degradation
    Carolyn K Suzuki; Fiscal Year: 2012
    ..The surveillance system that oversees mitochondrial protein quality control is composed of ATP-dependent proteases, which degrade misfolded and damaged proteins, as well as molecular ..
  22. Role of Autophagy in Cancer
    Eileen White; Fiscal Year: 2013
    ..This protein and organelle quality control function of autophagy is also highly conserved and required for homeostasis...
  23. Intravenous Protein Therapy for Treatment of Congenital Muscular Dystrophy
    Bradley L Hodges; Fiscal Year: 2010
    ..of stable cell lines for the production of the recombinant human laminin isoform, as well as the attendant quality control assays to verify the structure, purity, bioactivity, and stability of the recombinant human laminin isoform...
  24. Research and Development of a Novel System to Produce Polysaccharide Conjugate Va
    Peng George Wang; Fiscal Year: 2013
    ..glycoconjugate vaccines for the clinical use, it still suffers variable batch-to-batch composition, difficult quality control, inconsistent potency and high production cost...
  25. Randomized trial of active vitamin D, cholecalciferol and placebo for CKD-MBD
    Sharon M Moe; Fiscal Year: 2011
    ..the Data Coordinating Center will develop a web based data entry system, randomization protocol, and SOP and quality control (QC) procedures;b) the DXA coordinating center will develop SOP and QC procedures, data transfer methods, and ..
  26. Adiporedoxin, a Novel Player in Adipokine Secretion
    Paul F Pilch; Fiscal Year: 2013
    ..This very important area of quality control for proteins secreted from adipocytes has been minimally investigated, and the topic has important ..
  27. Examination of Reward Processing in the Treatment of Adolescent Major Depression
    Randy Patrick Auerbach; Fiscal Year: 2013
    ..The course addresses different aspects of clinical trials including study design, quality control, and biostatistical applications...
  28. Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field Center
    KIANG J LIU; Fiscal Year: 2013
    ..will take full advantage of CARDIA's outstanding database, specimen bank, team of investigators, quality control procedures, and organizational structure...
  29. RNA quality control and environmental stress
    Sandra L Wolin; Fiscal Year: 2013
    ....
  30. Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field Center
    KIANG J LIU; Fiscal Year: 2012
    ..will take full advantage of CARDIA's outstanding database, specimen bank, team of investigators, quality control procedures, and organizational structure...
  31. CARDIA
    KIANG J LIU; Fiscal Year: 2009
    ..will take full advantage of CARDIA's outstanding database, specimen bank, team of investigators, quality control procedures, and organizational structure...
  32. CARDIA
    KIANG J LIU; Fiscal Year: 2011
    ..will take full advantage of CARDIA's outstanding database, specimen bank, team of investigators, quality control procedures, and organizational structure...
  33. CARDIA
    KIANG J LIU; Fiscal Year: 2010
    ..will take full advantage of CARDIA's outstanding database, specimen bank, team of investigators, quality control procedures, and organizational structure...
  34. Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field Center
    Pamela Schreiner; Fiscal Year: 2012
    ..outstanding database and specimen bank, and our team of investigators, organizational structure, and quality control procedures...
  35. Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field Center
    Stephen Sidney; Fiscal Year: 2013
    ..outstanding database and specimen bank, and our team of investigators, organizational structure, and quality control procedures...
  36. Coronary Artery Risk Development in Young Adults (CARDIA) - Field Center
    Cora E Lewis; Fiscal Year: 2012
    ..outstanding database and specimen bank, and our team of investigators, organizational structure, and quality control procedures...
  37. Defining the interaction of FCRLA with immunoglobulin
    PETER DANIEL BURROWS; Fiscal Year: 2013
    ..FCRLA may thus play an essential role in the intracellular quality control system that ensures the correct production of antibodies...
  38. Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field Center
    Pamela Schreiner; Fiscal Year: 2013
    ..outstanding database and specimen bank, and our team of investigators, organizational structure, and quality control procedures...
  39. CARDIA
    Cora E Lewis; Fiscal Year: 2011
    ..outstanding database and specimen bank, and our team of investigators, organizational structure, and quality control procedures...
  40. Coronary Artery Risk Development in Young Adults (CARDIA) - Field Center
    Cora E Lewis; Fiscal Year: 2013
    ..outstanding database and specimen bank, and our team of investigators, organizational structure, and quality control procedures...
  41. CARDIA
    Pamela Schreiner; Fiscal Year: 2011
    ..outstanding database and specimen bank, and our team of investigators, organizational structure, and quality control procedures...
  42. CARDIA
    Stephen Sidney; Fiscal Year: 2010
    ..outstanding database and specimen bank, and our team of investigators, organizational structure, and quality control procedures...
  43. CARDIA
    Cora E Lewis; Fiscal Year: 2010
    ..outstanding database and specimen bank, and our team of investigators, organizational structure, and quality control procedures...
  44. CARDIA
    Cora E Lewis; Fiscal Year: 2009
    ..outstanding database and specimen bank, and our team of investigators, organizational structure, and quality control procedures...
  45. CARDIA
    Stephen Sidney; Fiscal Year: 2009
    ..outstanding database and specimen bank, and our team of investigators, organizational structure, and quality control procedures...
  46. CARDIA
    Stephen Sidney; Fiscal Year: 2011
    ..outstanding database and specimen bank, and our team of investigators, organizational structure, and quality control procedures...
  47. CARDIA
    Pamela J Schreiner; Fiscal Year: 2009
    ..outstanding database and specimen bank, and our team of investigators, organizational structure, and quality control procedures...
  48. CARDIA
    Sharina Person; Fiscal Year: 2009
    ..outstanding database and specimen bank, and our team of investigators, organizational structure, and quality control procedures...
  49. Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field Center
    Stephen Sidney; Fiscal Year: 2012
    ..outstanding database and specimen bank, and our team of investigators, organizational structure, and quality control procedures...
  50. CARDIA
    Pamela J Schreiner; Fiscal Year: 2010
    ..outstanding database and specimen bank, and our team of investigators, organizational structure, and quality control procedures...
  51. Genetics of Meiosis and Recombination in Mice
    John C Schimenti; Fiscal Year: 2013
    ..In sum, this project will elucidate the genetic quality control mechanisms operate in mammalian gametes...
  52. Degradation of Endoplasmic Reticulum Chaperones by Chaperone-mediated Autophagy
    Roberta Kiffin; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Autophagy is a major mechanism for cellular quality control, as it is responsible for the elimination of altered intracellular components in lysosomes...
  53. Thermoscientific TSQ Vantage Mass Spectrometer
    Leland H Hartwell; Fiscal Year: 2010
    ..signaling pathways;measure the relationship between protein ubiquitination pathways and protein quality control;validate serum biomarkers in cancers of the breast, pancreas, prostate, ovary, and lung;and measure the serum ..
  54. Processing and consequences of DNA-protein crosslinks in E. coli
    Kenneth N Kreuzer; Fiscal Year: 2012
    ..Finally, in the fourth aim, we follow up on our recent observation that the tmRNA translational quality control system is important for survival after 5-azacytidine treatment...
  55. Drug-like small molecule modulators of the Integrated Stress Response
    David Ron; Fiscal Year: 2010
    ..mechanisms: Retention and degradation of misfolded mutant proteins by the endoplasmic reticulum's (ER) quality control machinery leads to loss-of-function phenotypes (exemplified by lysosomal storage diseases)...
  56. cGMP manufacturing of PBI-220, a broad spectrum immunoadhesin therapeutic against
    LLOYD M YU; Fiscal Year: 2013
    ..We will manufacture PBI-220 using cGMP by establishing Manufacturing, Facilities, Quality Assurance (QA) and Quality Control (QC) departments...
  57. Regulated biosynthesis and function of ABC-transport systems
    Patrick H Thibodeau; Fiscal Year: 2013
    ..Finally, what cellular systems regulate CFTR trafficking? Specific CFTR-quality control interactions regulate these post-translational modifications, ultimately regulating the biological fate of ..
  58. Regulation of RNA Surveillance
    MILES FROME WILKINSON; Fiscal Year: 2012
    ..This proposal addresses newly discovered mechanisms responsible for regulating NMD that are particularly relevant for understanding normal neurological function and the genetic basis for mental retardation. ..
  59. Characterization of purified myocilin: glaucoma as a protein misfolding disease
    Raquel L Lieberman; Fiscal Year: 2013
    ..We further hypothesize that these defects are recognized by ER quality control machinery, which prevents the mutant myocilins from being secreted to the TEM...
  60. Degradation of Short Lived Regulatory Protein in Yeast
    MARK W HOCHSTRASSER; Fiscal Year: 2013
    ..Substrates include naturally short-lived regulatory factors and aberrant "protein quality control" (PQC) substrates...
  61. Endoplasmic reticulum quality control of mutant HexA enzyme in Tay-Sachs disease
    Devin Dersh; Fiscal Year: 2013
    ..It is well described that many common HexA mutants never exit the endoplasmic reticulum (ER) due to quality control mechanisms that prevent the enzyme from proceeding in the secretory pathway...
  62. Plan for Cardiovascular Research Training in Advanced Biostatistics, Aging, and H
    Dorairaj Prabhakaran; Fiscal Year: 2013
    ..recruitment and retention, evaluation of appropriate didactic coursework, research project inventory, quality control/assurance training development, e.g...
  63. Plasmodium Genus and P. falciparum - P. vivax FISH Assays
    Jyotsna Shah; Fiscal Year: 2009
    ..In Phase I, we optimized the fixation and hybridization conditions and set up Quality Control Procedures for the FISH assays...
  64. DEVELOPMENT OF AN IMPLANTABLE EMG MICRO-TELEMETER
    DAVID EDELL; Fiscal Year: 2006
    ..e. wrist, thumb, fingers) could be accomplished if multiple sources of high quality control signals were available...
  65. Replication of Association Signals Identified in Ulcerative Colitis GWAS
    Richard H Duerr; Fiscal Year: 2010
    ..ulcerative colitis GWAS using Illumina genotyping beadchip data from 977 cases and 2,122 controls that passed quality control and were matched, by gender and ancestry...
  66. Simian Virus 40 (SV40) uncoating and penetration
    Daniel Hebert; Fiscal Year: 2009
    ..The ER also possesses a quality control activity that ensures that only properly folded and assembled proteins are exported through the secretory ..
  67. A Phase l Study of Pyrimethamine in patients with GM-2 Gangliosidosis
    Bijan Almassian; Fiscal Year: 2007
    ..to obtain and/or retain its native 3-dimensional fold in the endoplasmic reticulum (ER) where intracellular quality control is performed to retain and degrade defective enzymes...
  68. 2012 Intrinsically Disordered Proteins Gordon Research Conference
    Rohit V Pappu; Fiscal Year: 2012
    ..such as transcriptional regulation, signal transduction, protein trafficking, protein homeostasis and quality control. Most biological functions are based on molecular recognition and complex networks are organized around a ..
  69. Screening for Inhibitors of the Integrated Stress Response
    David Ron; Fiscal Year: 2007
    ..the ER can have important pathophysiological consequences: For example, evidence suggests that loosening the quality control in the ER might allow mildly misfolded proteins that are otherwise functional to escape ER retention and ..
  70. Neonatal Chest Phantom for Computed Radiography Testing
    Steven Don; Fiscal Year: 2006
    ..to reduce the risk of induced malignancy from radiation exposure, In practice this requires a rigorous quality control process for clinical operations in radiology...
  71. PROTEIN QUALITY CONTROL IN THE ENDOPLASMIC RETICULUM
    KARL WITTRUP; Fiscal Year: 2001
    ..abstract]: Misfolded and unassembled proteins are retained in the endoplasmic reticulum via a process termed "quality control," ensuring that only native proteins are secreted to the extracellular space...
  72. Role of ER-Localized Chaperones in Toxin Pathogenesis
    David Haslam; Fiscal Year: 2006
    ..This recently discovered pathway from the endoplasmic reticulum lumen to the cytoplasm represents a cellular quality control mechanism responsible for degrading host proteins that misfold in the ER lumen (termed ER-associated ..
  73. Innovative Systems & Educational Tools to Advance an Established Diabetic Retinop
    GARY GREGORY; Fiscal Year: 2009
    ..It features a validated robust telemedicine platform with sophisticated, quality control oversight and expert evaluation...
  74. TREATMENT OF PANIC DISORDER--LONG TERM STRATEGIES
    Scott Woods; Fiscal Year: 2003
    ..began somewhat later than we predicted because of rigorous attention to state-of-the-art assessment and quality control procedures. Careful thought about essential assessment domains appears to have been well worth the effort...
  75. TREATMENT OF PANIC DISORDER--LONG TERM STRATEGIES
    Jack Gorman; Fiscal Year: 2003
    ..began somewhat later than we predicted because of rigorous attention to state-of-the -art assessment and quality control procedures. Careful thought about essential assessment domains appears to have been well worth the effort...
  76. Proteostasis sensors to assess the cellular protein folding capacity
    RICHARD I contact MORIMOTO; Fiscal Year: 2010
    ..The long-term health of all metazoan cells is inextricably linked to protein quality control. This is achieved by proteostasis, a complex network of molecular interactions that determines the health of ..