quality control

Summary

Summary: A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)

Top Publications

  1. pmc The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
    Leming Shi
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA
    Nat Biotechnol 28:827-38. 2010
  2. ncbi A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    B M Bolstad
    Group in Biostatistics, University of California, Berkeley, CA 94720, USA
    Bioinformatics 19:185-93. 2003
  3. pmc The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews
    Penny Whiting
    Centre for Reviews and Dissemination, University of York, England, UK
    BMC Med Res Methodol 3:25. 2003
  4. pmc Quality control and preprocessing of metagenomic datasets
    Robert Schmieder
    Department of Computer Science, Computational Science Research Center, San Diego State University, San Diego, CA 92182, USA
    Bioinformatics 27:863-4. 2011
  5. pmc NGS QC Toolkit: a toolkit for quality control of next generation sequencing data
    Ravi K Patel
    Functional Genomics and Bioinformatics Laboratory, National Institute of Plant Genome Research NIPGR, New Delhi, India
    PLoS ONE 7:e30619. 2012
  6. ncbi Empirical studies assessing the quality of health information for consumers on the world wide web: a systematic review
    Gunther Eysenbach
    Centre for Global eHealth Innovation, Toronto General Hospital, 190 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    JAMA 287:2691-700. 2002
  7. doi Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors
    Pamela Nicholson
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland
    Cell Mol Life Sci 67:677-700. 2010
  8. pmc The RIN: an RNA integrity number for assigning integrity values to RNA measurements
    Andreas Schroeder
    Agilent Technologies, Hewlett Packard Strasse 8, 76337 Waldbronn, Germany
    BMC Mol Biol 7:3. 2006
  9. pmc Evaluation of QUADAS, a tool for the quality assessment of diagnostic accuracy studies
    Penny F Whiting
    MRC Health Services Research Collaboration, Department of Social Medicine, Canynge Hall, Whiteladies Road, Bristol, UK
    BMC Med Res Methodol 6:9. 2006
  10. pmc The relationship of previous training and experience of journal peer reviewers to subsequent review quality
    Michael L Callaham
    Division of Emergency Medicine, University of California, San Francisco, United States of America
    PLoS Med 4:e40. 2007

Detail Information

Publications328 found, 100 shown here

  1. pmc The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
    Leming Shi
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA
    Nat Biotechnol 28:827-38. 2010
    ..The conclusions and recommendations from MAQC-II should be useful for regulatory agencies, study committees and independent investigators that evaluate methods for global gene expression analysis...
  2. ncbi A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    B M Bolstad
    Group in Biostatistics, University of California, Berkeley, CA 94720, USA
    Bioinformatics 19:185-93. 2003
    ..Normalization is a process for reducing this variation. It is common to see non-linear relations between arrays and the standard normalization provided by Affymetrix does not perform well in these situations...
  3. pmc The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews
    Penny Whiting
    Centre for Reviews and Dissemination, University of York, England, UK
    BMC Med Res Methodol 3:25. 2003
    ..The aim of this project was to combine empirical evidence and expert opinion in a formal consensus method to develop a tool to be used in systematic reviews to assess the quality of primary studies of diagnostic accuracy...
  4. pmc Quality control and preprocessing of metagenomic datasets
    Robert Schmieder
    Department of Computer Science, Computational Science Research Center, San Diego State University, San Diego, CA 92182, USA
    Bioinformatics 27:863-4. 2011
    Here, we present PRINSEQ for easy and rapid quality control and data preprocessing of genomic and metagenomic datasets...
  5. pmc NGS QC Toolkit: a toolkit for quality control of next generation sequencing data
    Ravi K Patel
    Functional Genomics and Bioinformatics Laboratory, National Institute of Plant Genome Research NIPGR, New Delhi, India
    PLoS ONE 7:e30619. 2012
    ..However, quality control (QC) of sequence data generated from these technologies is extremely important for meaningful downstream ..
  6. ncbi Empirical studies assessing the quality of health information for consumers on the world wide web: a systematic review
    Gunther Eysenbach
    Centre for Global eHealth Innovation, Toronto General Hospital, 190 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    JAMA 287:2691-700. 2002
    ..The quality of consumer health information on the World Wide Web is an important issue for medicine, but to date no systematic and comprehensive synthesis of the methods and evidence has been performed...
  7. doi Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors
    Pamela Nicholson
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland
    Cell Mol Life Sci 67:677-700. 2010
    ..However, as we review here, NMD is far from being a simple quality control mechanism; it also regulates the stability of many wild-type transcripts...
  8. pmc The RIN: an RNA integrity number for assigning integrity values to RNA measurements
    Andreas Schroeder
    Agilent Technologies, Hewlett Packard Strasse 8, 76337 Waldbronn, Germany
    BMC Mol Biol 7:3. 2006
    ..The advent of microcapillary electrophoretic RNA separation provides the basis for an automated high-throughput approach, in order to estimate the integrity of RNA samples in an unambiguous way...
  9. pmc Evaluation of QUADAS, a tool for the quality assessment of diagnostic accuracy studies
    Penny F Whiting
    MRC Health Services Research Collaboration, Department of Social Medicine, Canynge Hall, Whiteladies Road, Bristol, UK
    BMC Med Res Methodol 6:9. 2006
    ..Although QUADAS has been used in several systematic reviews, it has not been formally validated. The objective was to evaluate the validity and usefulness of QUADAS...
  10. pmc The relationship of previous training and experience of journal peer reviewers to subsequent review quality
    Michael L Callaham
    Division of Emergency Medicine, University of California, San Francisco, United States of America
    PLoS Med 4:e40. 2007
    ..More objective selection of peer reviewers might improve the journal peer review process and thus the quality of published science...
  11. pmc Data quality control in genetic case-control association studies
    Carl A Anderson
    Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Protoc 5:1564-73. 2010
    ..Issues concerning study design and marker selection in case-control studies have been discussed in our earlier protocols. This protocol, which is routinely used in our labs, should take approximately 8 h to complete...
  12. pmc Laboratory evolution of fast-folding green fluorescent protein using secretory pathway quality control
    Adam C Fisher
    School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 3:e2351. 2008
    ..This prompted us to hypothesize that the folding quality control inherent to this secretory pathway could be used as a platform for engineering similar 'superfolded' proteins...
  13. ncbi Does the CONSORT checklist improve the quality of reports of randomised controlled trials? A systematic review
    Amy C Plint
    Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada
    Med J Aust 185:263-7. 2006
    ..To determine whether the adoption of the CONSORT checklist is associated with improvement in the quality of reporting of randomised controlled trials (RCTs)...
  14. doi Comparative proteomic analysis identifies a role for SUMO in protein quality control
    Michael H Tatham
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Sci Signal 4:rs4. 2011
    ..Together, these findings suggest multiple, proteasome-independent roles for SUMOs in the cellular response to the accumulation of misfolded proteins...
  15. ncbi Adjustment of systematic microarray data biases
    Monica Benito
    Department of Statistics and Econometrics, University of Carlos III, Madrid, Spain
    Bioinformatics 20:105-14. 2004
    ..These systematic effects present a substantial hurdle to the analysis of microarray data...
  16. ncbi NORDCAN--a Nordic tool for cancer information, planning, quality control and research
    Gerda Engholm
    NORDCAN Secretariat, Department of Cancer Prevention and Documentation, Danish Cancer Society, Strandboulevarden 49, Copenhagen Ø, Denmark
    Acta Oncol 49:725-36. 2010
    ....
  17. pmc Quality control and quality assurance in genotypic data for genome-wide association studies
    Cathy C Laurie
    Department of Biostatistics, University of Washington, Seattle, Washington, USA
    Genet Epidemiol 34:591-602. 2010
    ..attention to data quality has been appreciated for some time in this field, and a number of strategies for quality control and quality assurance (QC/QA) have been developed...
  18. ncbi Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses
    L L Kjaergard
    Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshospitalet, DK 2100 Copenhagen, Denmark
    Ann Intern Med 135:982-9. 2001
    ..To explore whether reported methodologic quality affects estimated intervention effects in randomized trials and contributes to discrepancies between the results of large randomized trials and small randomized trials in meta-analyses...
  19. pmc Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies
    Daniah Trabzuni
    Reta Lilla Weston Laboratories and Departments of Molecular Neuroscience, UCL Institute of Neurology, London, UK
    J Neurochem 119:275-82. 2011
    ..We assessed the accuracy of the array data using QuantiGene, as an independent non-PCR-based method. These quality control parameters will allow database users to assess data accuracy...
  20. doi Strategies for quality control of Chinese medicines
    S P Li
    State Key Laboratory for Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China
    J Pharm Biomed Anal 55:802-9. 2011
    Chinese medicines (CM) have been attracting interest and acceptance in many countries. Quality control is vital for ensuring the safety and efficacy of CM...
  21. ncbi Simpleaffy: a BioConductor package for Affymetrix Quality Control and data analysis
    Claire L Wilson
    Paterson Institute for Cancer Research, Manchester M20 4BX, UK
    Bioinformatics 21:3683-5. 2005
    b>Quality Control is a fundamental aspect of successful microarray data analysis...
  22. ncbi Improved quality control method for Fufang Danshen preparations through simultaneous determination of phenolic acids, saponins and diterpenoid quinones by HPLC coupled with diode array and evaporative light scattering detectors
    Ying Jie Wei
    Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Ministry of Education, Nanjing 210009, China
    J Pharm Biomed Anal 45:775-84. 2007
    ..by various manufacturers with the raw materials from different sources, pose a serious challenge to the quality control of this herb medicine...
  23. doi Statistical issues in quality control of proteomic analyses: good experimental design and planning
    David A Cairns
    Clinical and Biomedical Proteomics Group, Section of Oncology and Clinical Research, Leeds Cancer Research UK Centre, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    Proteomics 11:1037-48. 2011
    b>Quality control is becoming increasingly important in proteomic investigations as experiments become more multivariate and quantitative. Quality control applies to all stages of an investigation and statistics can play a key role...
  24. pmc Quality control in microarray assessment of gene expression in human airway epithelium
    Tina Raman
    Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, USA
    BMC Genomics 10:493. 2009
    ..The focus of this study was to establish rigorous quality control parameters to ensure that microarray assessment of the airway epithelium is not confounded by experimental ..
  25. pmc Transcriptome sequencing of the Microarray Quality Control (MAQC) RNA reference samples using next generation sequencing
    Shrinivasrao P Mane
    Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA
    BMC Genomics 10:264. 2009
    ..As a preliminary evaluation of these promising technologies, we performed deep sequencing of cDNA synthesized from the Microarray Quality Control (MAQC) reference RNA samples using Roche's 454 Genome Sequencer FLX.
  26. doi Production, quality control, stability and pharmacotoxicity of cGMP-produced Plasmodium falciparum AMA1 FVO strain ectodomain expressed in Pichia pastoris
    Bart W Faber
    Department of Parasitology, Biomedical Primate Research Center, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
    Vaccine 26:6143-50. 2008
    ..These formulations also showed no pharmacotoxicity in rabbits. The final product conformed to preset criteria and was judged suitable for use in human clinical trials...
  27. pmc DrugBank: a comprehensive resource for in silico drug discovery and exploration
    David S Wishart
    Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E8
    Nucleic Acids Res 34:D668-72. 2006
    ..DrugBank is available at http://redpoll.pharmacy.ualberta.ca/drugbank/...
  28. pmc Randomized trials published in some Chinese journals: how many are randomized?
    Taixiang Wu
    Chinese Cochrane Centre, Chinese Evidence Based Medicine Centre, International Clinical Epidemiology Network INCLEN, West China Hospital, Sichuan University, Chengdu, PR China
    Trials 10:46. 2009
    ..We investigated the adequacy of randomization of clinical trials published in recent years in China to determine how many of them met acceptable standards for allocating participants to treatment groups...
  29. pmc The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Molndal, Sweden
    Alzheimers Dement 7:386-395.e6. 2011
    ..The Alzheimer's Association has initiated a global quality control program to estimate and monitor variability of measurements, quantify batch-to-batch assay variations, and ..
  30. ncbi Highly parallel SNP genotyping
    J B Fan
    llumina, Inc, San Diego, California 92121, USA
    Cold Spring Harb Symp Quant Biol 68:69-78. 2003
  31. pmc Anti-malarial drug quality in Lagos and Accra - a comparison of various quality assessments
    Roger Bate
    American Enterprise Institute, Washington, D C, USA
    Malar J 9:157. 2010
    ..Since intelligence provided by investigators indicates that some counterfeit producers may be adapting products to pass Minilab tests, the results are compared with those from a Raman spectrometer and discrepancies are discussed...
  32. ncbi The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials
    D Moher
    University of Ottawa, Thomas C Chalmers Centre for Systematic Reviews, Ottawa, Ontario, Canada
    Lancet 357:1191-4. 2001
    ..In sum, the CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results...
  33. pmc NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins
    Kim D Pruitt
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Rm 6An 12J, 45 Center Drive, Bethesda, MD 20892 6510, USA
    Nucleic Acids Res 35:D61-5. 2007
    ..The format of all RefSeq records is validated, and an increasing number of tests are being applied to evaluate the quality of sequence and annotation, especially in the context of complete genomic sequence...
  34. ncbi Quality control and data reduction procedures for accelerometry-derived measures of physical activity
    Rachel Colley
    Children s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario
    Health Rep 21:63-9. 2010
    This article describes four key quality control and data reduction issues that researchers should consider when using accelerometry to measure physical activity: monitor reliability, spurious data, monitor wear time, and number of valid ..
  35. ncbi Analytical methods for quality control of propolis
    P G Pietta
    C N R, I T B, V le F lli Cervi, 93, Segrate MI, Italy
    Fitoterapia 73:S7-20. 2002
    ..Direct analysis by APCI-IT-MS represents a valuable alternative to obtain typical fingerprints of propolis and a reliable identification of a large number of propolis components...
  36. pmc Guidelines on good clinical laboratory practice: bridging operations between research and clinical research laboratories
    J Ezzelle
    PPD Inc, 929 North Front Street, Wilmington, NC 28401 3331, United States
    J Pharm Biomed Anal 46:18-29. 2008
    ....
  37. ncbi The quality of reporting of trial abstracts is suboptimal: survey of major general medical journals
    Otavio Berwanger
    Research Institute of Heart Hospital IEP HCor, Sao Paulo SP, Brazil
    J Clin Epidemiol 62:387-92. 2009
    ..To evaluate the quality of reporting of abstracts describing randomized controlled trials (RCTs) published in four major general medical journals...
  38. doi mRNA and microRNA quality control for RT-qPCR analysis
    C Becker
    Physiology Weihenstephan, Technical University Munich, Freising, Germany
    Methods 50:237-43. 2010
    ..RNA quality control may also be integrated in the routine analysis of new applications like the investigation of microRNA (miRNA) ..
  39. doi Quality control for genome-wide association studies
    Michael E Weale
    Department of Medical and Molecular Genetics, King s College London, Guy s Hospital, London, UK
    Methods Mol Biol 628:341-72. 2010
    This chapter is a comprehensive review of quality control (QC) methods for SNP-based genotyping panels used in genome-wide association studies...
  40. doi No-go decay: a quality control mechanism for RNA in translation
    Yuriko Harigaya
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721 0106, USA
    Wiley Interdiscip Rev RNA 1:132-41. 2010
    Eukaryotic cells have evolved multiple quality control mechanisms that recognize and eliminate defective mRNA during the process of translation...
  41. doi Improving the quality of reporting alcohol outcome studies: effects of the CONSORT statement
    Benjamin O Ladd
    Center on Alcoholism, Substance Abuse, and Addictions CASAA, 2650 Yale Blvd SE, MSC11 6280, Albuquerque, NM 87106, USA
    Addict Behav 35:660-6. 2010
    ..Results suggest that efforts to improve reporting such as the CONSORT guidelines can be useful and influential...
  42. ncbi 111In-pentetreotide scintigraphy: procedure guidelines for tumour imaging
    Emilio Bombardieri
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Eur J Nucl Med Mol Imaging 37:1441-8. 2010
    ..The aim of this guideline is to assist nuclear medicine physicians in recommending, performing, reporting and interpreting the results of (111)In-pentetreotide scintigraphy...
  43. ncbi Simultaneous quantification of 14 ginsenosides in Panax ginseng C.A. Meyer (Korean red ginseng) by HPLC-ELSD and its application to quality control
    Su Na Kim
    Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 110 460, South Korea
    J Pharm Biomed Anal 45:164-70. 2007
    ..The amounts of the 14 ginsenosides in the various ginseng samples could be analyzed simultaneously. This validated HPLC method is expected to provide a new basis for the quality assessment of ginseng products...
  44. doi Identifying actives from HTS data sets: practical approaches for the selection of an appropriate HTS data-processing method and quality control review
    Tong Ying Shun
    University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA, USA
    J Biomol Screen 16:1-14. 2011
    ..Step 1 is to determine the most appropriate HTS data-processing method and establish criteria for quality control review and active identification from 3-day assay signal window and DMSO validation tests...
  45. doi Has the quality of abstracts for randomised controlled trials improved since the release of Consolidated Standards of Reporting Trial guideline for abstract reporting? A survey of four high-profile anaesthesia journals
    Ozlem S Can
    Department of Anaesthesiology and Intensive Care, Faculty of Medicine, Ankara University, Ankara, Turkey
    Eur J Anaesthesiol 28:485-92. 2011
    ..The current study assessed whether there has been an improvement in the quality of RCT abstracts published in main anaesthesia journals since this new guideline was introduced...
  46. ncbi Empirical evidence of design-related bias in studies of diagnostic tests
    J G Lijmer
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, The Netherlands
    JAMA 282:1061-6. 1999
    ..The literature contains a large number of potential biases in the evaluation of diagnostic tests. Strict application of appropriate methodological criteria would invalidate the clinical application of most study results...
  47. pmc A simple and fast two-locus quality control test to detect false positives due to batch effects in genome-wide association studies
    Sang Hong Lee
    Queensland Institute of Medical Research, Herston, Queensland, Australia
    Genet Epidemiol 34:854-62. 2010
    The impact of erroneous genotypes having passed standard quality control (QC) can be severe in genome-wide association studies, genotype imputation, and estimation of heritability and prediction of genetic risk based on single nucleotide ..
  48. doi DNA yield and quality of saliva samples and suitability for large-scale epidemiological studies in children
    A C Koni
    College of Medicine, Veterinary and Life Sciences, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland, UK
    Int J Obes (Lond) 35:S113-8. 2011
    ..To evaluate two saliva collection methods for DNA yield and quality as applied to a large, integrated, multicentre, European project involving the collection of biological material from children...
  49. pmc PRIDE: quality control in a proteomics data repository
    Attila Csordas
    EMBL Outstation, European Bioinformatics Institute EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
    Database (Oxford) 2012:bas004. 2012
    ..Here, we describe the PRIDE curation pipeline and its practical application in quality control of complex data depositions. DATABASE URL: http://www.ebi.ac.uk/pride/.
  50. ncbi Live cell quality control and utility of real-time cell electronic sensing for assay development
    Shelli L Kirstein
    ACEA Biosciences Inc, San Diego, CA 92121, USA
    Assay Drug Dev Technol 4:545-53. 2006
    ..that provide a quantitative account of cell behavior and can be used as a diagnostic tool for cellular quality control. The utility of the specific signature patterns was shown by demonstrating the significant differences in ..
  51. doi pH measurement as quality control on human post mortem brain tissue: a study of the BrainNet Europe consortium
    C M Monoranu
    Department of Neuropathology, Institute of Pathology, University of Wurzburg, Germany
    Neuropathol Appl Neurobiol 35:329-37. 2009
    ..Here we examine the influence of several premortem and post mortem factors on pH, and discuss the role of pH as a biochemical marker for brain tissue quality...
  52. ncbi Digital slides: present status of a tool for consultation, teaching, and quality control in pathology
    Rafael Rocha
    Department of Pathology Universidade Federal de Minas Gerais, Brazil
    Pathol Res Pract 205:735-41. 2009
    ..Overcoming this major drawback may revolutionize the surgical pathologist's activity and slide storing...
  53. pmc External quality assessment for KRAS testing is needed: setup of a European program and report of the first joined regional quality assessment rounds
    Ellen Bellon
    University of Leuven, Centre for Human Genetics, Research Unit Biomedical Quality Assurance Leuven, Herestraat 49, Box 602, 3000, Leuven, Belgium
    Oncologist 16:467-78. 2011
    ..We aim to further expand this program to more laboratories to provide a robust estimate of the quality of KRAS testing in Europe, and provide the basis for remedial measures and harmonization...
  54. ncbi Substandard tuberculosis drugs on the global market and their simple detection
    K F Laserson
    Division of TB Elimination, National Centers for HIV AIDS, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Int J Tuberc Lung Dis 5:448-54. 2001
    ..The prevalence of substandard anti-tuberculosis drugs is unknown. To maximize the effectiveness of tuberculosis (TB) control efforts, simple, inexpensive drug quality screening methods are needed...
  55. ncbi Recognition of errors in three-dimensional structures of proteins
    M J Sippl
    Center for Applied Molecular Engineering, University of Salzburg, Austria
    Proteins 17:355-62. 1993
    ..The techniques are even applicable in cases where only the C alpha trace of a protein conformation is available. The capabilities of the technique are demonstrated using correct and incorrect protein folds...
  56. pmc An endoribonuclease functionally linked to perinuclear mRNP quality control associates with the nuclear pore complexes
    Michal Skruzny
    Biochemie Zentrum der Universität Heidelberg BZH, Heidelberg, Germany
    PLoS Biol 7:e8. 2009
    ..Here we report that the conserved PIN domain protein Swt1 is an RNA endonuclease that participates in quality control of nuclear mRNPs and can associate with the nuclear pore complex (NPC)...
  57. ncbi Diagnostic challenges for multiplexed protein microarrays
    Stephen R Master
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Drug Discov Today 11:1007-11. 2006
    ..this new assay format presents several new operational issues for the clinical laboratory, such as the quality control of protein-microarray-based assays, the release of unrequested test data and the use of diagnostic algorithms ..
  58. ncbi Quality control of Cordyceps sinensis, a valued traditional Chinese medicine
    S P Li
    Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China
    J Pharm Biomed Anal 41:1571-84. 2006
    ..Therefore, quality control of C. sinensis and its products is very important to ensure their safety and efficacy...
  59. pmc Consistency of predictive signature genes and classifiers generated using different microarray platforms
    X Fan
    College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
    Pharmacogenomics J 10:247-57. 2010
    ..As part of the MicroArray Quality Control Phase II (MAQC-II) project, we show in this study 80-90% cross-platform prediction consistency using a large ..
  60. ncbi Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program
    J Gabert
    Department of Hematology Biology, Institut Paoli Calmettes, France
    Leukemia 17:2318-57. 2003
    ..During our program, three quality control rounds on a large series of coded RNA samples were performed including a balanced randomized assay, which ..
  61. ncbi Investigation of product quality between extemporaneously compounded progesterone vaginal suppositories and an approved progesterone vaginal gel
    Vorapann Mahaguna
    PharmaForm, LLC, Austin, TX 78758, USA
    Drug Dev Ind Pharm 30:1069-78. 2004
    ..This data indicates that pharmacy compounded delivery systems for progesterone should be used with caution...
  62. pmc Assessment of the quality of reporting in abstracts of randomized controlled trials published in five leading Chinese medical journals
    Yaolong Chen
    Chinese Cochrane Centre, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    PLoS ONE 5:e11926. 2010
    ..However, little is known about the quality of reporting in abstracts of RCTs published in medical journals in China...
  63. ncbi Validation and application of a liquid chromatographic-mass spectrometric method for determination of artesunate in pharmaceutical samples
    N Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Pharm Biomed Anal 45:149-53. 2007
    ..3 (70:30, v/v) at a flow rate of 1 mL/min. The assay was implemented for the analysis of artesunate for injection purchased from Guilin Pharmaceutical Company in China...
  64. doi Influence of trial registration on reporting quality of randomized trials: study from highest ranked journals
    L Reveiz
    Colombian Cochrane Branch, Fundación Universitaria Sanitas, Bogota, Colombia
    J Clin Epidemiol 63:1216-22. 2010
    ..To evaluate the reporting quality of key methodological items of randomized control trials (RCTs) in 55 of the highest ranked journals...
  65. pmc Opportunities and challenges for improving the quality of reporting clinical research: CONSORT and beyond
    David Moher
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada
    CMAJ 171:349-50. 2004
  66. pmc Analysis of cell-based RNAi screens
    Michael Boutros
    Signaling and Functional Genomics, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Genome Biol 7:R66. 2006
    ..dkfz.de/signaling/cellHTS). The method is useful for the analysis and documentation of individual RNAi screens. Moreover, it is a prerequisite for the integration of multiple experiments...
  67. doi Quality control for quantitative PCR based on amplification compatibility test
    Ales Tichopad
    Technical University Munich, Physiology Weihenstephan, Weihenstephaner Berg 3, 85354 Freising Weihenstephan, Germany
    Methods 50:308-12. 2010
    ..Finally we stress that the performance of the amplification compatibility test as a quality control procedure depends on the quality of the reference set.
  68. pmc Microarray meta-analysis database (M(2)DB): a uniformly pre-processed, quality controlled, and manually curated human clinical microarray database
    Wei Chung Cheng
    Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan
    BMC Bioinformatics 11:421. 2010
    ..However, collecting data of special interest from public microarray repositories often present major practical problems. Moreover, including low-quality data may significantly reduce meta-analysis efficiency...
  69. ncbi AAPM/RSNA physics tutorial for residents: MR artifacts, safety, and quality control
    Jiachen Zhuo
    Department of Radiology, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201, USA
    Radiographics 26:275-97. 2006
    ....
  70. ncbi User attitudes in analyzing digital slides in a quality control test bed: a preliminary study
    Vincenzo Della Mea
    Department of Mathematics and Computer Science, University of Udine, via delle Scienze 206, 33100 Udine, Italy
    Comput Methods Programs Biomed 82:177-86. 2006
    ..Possible applications of digital slides are then discussed, including undergraduate and professional education, quality control, and image analysis on full samples as well as on tissue microarrays.
  71. pmc Identification and correction of abnormal, incomplete and mispredicted proteins in public databases
    Alinda Nagy
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, H 1113 Budapest, Hungary
    BMC Bioinformatics 9:353. 2008
    ..Here we describe the MisPred approach that may provide an efficient means for the quality control of databases...
  72. ncbi Challenges in routine implementation and quality control of rapid diagnostic tests for malaria--Rufiji District, Tanzania
    Meredith L McMorrow
    Malaria Branch, Division of Parasitic Diseases, National Center for Zoonotic Vector Borne and Enteric Diseases, US Centers for Disease Control and Prevention, USA
    Am J Trop Med Hyg 79:385-90. 2008
    ..Current World Health Organization (WHO) guidelines for quality control of RDTs provide detailed instructions on pre-field testing, but offer little guidance for quality assurance ..
  73. pmc In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing
    Steven D Brown
    The Clinical Microbiology Institute, 9725 SW Commerce Circle, Wilsonville, Oregon 97070, USA
    Antimicrob Agents Chemother 53:1271-4. 2009
    ..For the majority of species, the activity of ceftaroline was comparable or superior to that of ceftriaxone. MIC and/or disk diffusion quality control ranges of ceftaroline were determined for five standard ATCC reference strains.
  74. ncbi Mesenchymal content of fresh bone marrow: a proposed quality control method for cell therapy
    Richard Veyrat-Masson
    Hematology Biology Department, U F de Biologie et Caractérisation Cellulaires, Hotel Dieu, CHU, Clermont Ferrand, France
    Br J Haematol 139:312-20. 2007
    ..We propose a cell quality control on un-manipulated BM cell suspensions to quantify the mesenchymal compartment with regard to varying donor ..
  75. ncbi Quality control for functional magnetic resonance imaging using automated data analysis and Shewhart charting
    A Simmons
    Department of Clinical Neurosciences, Institute of Psychiatry, Maudsley Hospital, London, United Kingdom
    Magn Reson Med 41:1274-8. 1999
    A data acquisition and analysis protocol for quality control (QC) of functional magnetic resonance imaging studies is presented...
  76. ncbi The revised CONSORT statement for reporting randomized trials: explanation and elaboration
    D G Altman
    ICRF Medical Statistics Group, Centre for Statistics in Medicine, Institute of Health Sciences, Old Road, Headington, Oxford OX3 7LF, United Kingdom
    Ann Intern Med 134:663-94. 2001
    ..consort-statement.org ) should be helpful resources to improve reporting of randomized trials. Throughout the text, terms marked with an asterisk are defined at end of text...
  77. ncbi Protein N-glycosylation along the secretory pathway: relationship to organelle topography and function, protein quality control, and cell interactions
    Jürgen Roth
    Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Chem Rev 102:285-303. 2002
  78. doi Quality of reporting of randomized controlled trials in general endocrinology literature
    Lorena P Rios
    Father Sean O Sullivan Research Centre, St Joseph s Healthcare, Hamilton, Ontario, L8N 4A6 Canada
    J Clin Endocrinol Metab 93:3810-6. 2008
    ..The reporting quality of randomized controlled trials (RCTs) is poor in general medicine and several areas of specialization but unknown in endocrinology...
  79. doi How to interpret a genome-wide association study
    Thomas A Pearson
    Office of Population Genomics, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 2154, USA
    JAMA 299:1335-44. 2008
    ..This article describes the design, interpretation, application, and limitations of GWA studies for clinicians and scientists for whom this evolving science may have great relevance...
  80. pmc Quality control of ribosomal RNA mediated by polynucleotide phosphorylase and RNase R
    Zhuan Fen Cheng
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, FL 33101, USA
    Proc Natl Acad Sci U S A 100:6388-93. 2003
    ..The data are consistent with a model in which PNPase and RNase R mediate a previously unknown quality control process that normally removes defective rRNAs as soon as they are generated...
  81. pmc Production and validation of durable, high quality standardized malaria microscopy slides for teaching, testing and quality assurance during an era of declining diagnostic proficiency
    Jason D Maguire
    U S Naval Medical Research Unit No 2 NAMRU 2, Jakarta, Indonesia
    Malar J 5:92. 2006
    ..Sets of Giemsa-stained, blood smear slides with systematically verified composite diagnoses would contribute substantially to development of externally validated quality assurance systems for the microscopic diagnosis of malaria...
  82. ncbi Polycyclic aromatic hydrocarbon exposures of children in low-income families
    J C Chuang
    National Exposure Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    J Expo Anal Environ Epidemiol 9:85-98. 1999
    ..S. EPA's Integrated Risk System), most of which are of low volatility. The analysis of variance results showed that inner city participants had higher total exposure to B2 PAH than did rural participants...
  83. pmc PRISM framework: a paradigm shift for designing, strengthening and evaluating routine health information systems
    Anwer Aqil
    MEASURE Evaluation, 1616 N Fort Mayer Drive, Arlington, VA 22209, USA
    Health Policy Plan 24:217-28. 2009
    ....
  84. pmc Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES)
    Gunther Eysenbach
    J Med Internet Res 6:e34. 2004
    ..It is hoped that author adherence to the checklist will increase the usefulness of such reports...
  85. pmc Statistical analysis of real-time PCR data
    Joshua S Yuan
    Department of Plant Sciences, University of Tennessee, Knoxville, TN 37996, USA
    BMC Bioinformatics 7:85. 2006
    ..Based on the standard curve method and other useful data analysis methods, we present and compare four statistical approaches and models for the analysis of real-time PCR data...
  86. ncbi Computerised reminders and feedback in medication management: a systematic review of randomised controlled trials
    John W Bennett
    University Health Service, University of Queensland, Gordon Greenwood Building, Brisbane, Queensland 4072, Australia
    Med J Aust 178:217-22. 2003
    ..To systematically review randomised controlled trials (RCTs) of computer-generated medication reminders or feedback directed to healthcare providers or patients...
  87. pmc Where is the evidence that animal research benefits humans?
    Pandora Pound
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR
    BMJ 328:514-7. 2004
  88. pmc Incongruence between test statistics and P values in medical papers
    Emili García-Berthou
    Department of Environmental Sciences, University of Girona, E 17071 Girona, Spain
    BMC Med Res Methodol 4:13. 2004
    ..Given an observed test statistic and its degrees of freedom, one may compute the observed P value with most statistical packages. It is unknown to what extent test statistics and P values are congruent in published medical papers...
  89. ncbi MicroPreP: a cDNA microarray data pre-processing framework
    Sacha A F T van Hijum
    Molecular Genetics, University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute, Haren, The Netherlands
    Appl Bioinformatics 2:241-4. 2003
    ..The main features of this software are: LOWESS normalisation; merging of DNA microarray data from changing slide versions; outlier detection; and slide quality assessment...
  90. doi Extended guidelines for mtDNA typing of population data in forensic science
    Walther Parson
    Institute of Legal Medicine, Innsbruck Medical University, Innsbruck, Austria
    Forensic Sci Int Genet 1:13-9. 2007
    ..guidelines became necessary in regard to sample selection, amplification and sequencing strategies, as well as a posteriori quality control of mtDNA profiles. The notation of sequence data should thus reflect this growing knowledge.
  91. pmc Improving the reporting quality of nonrandomized evaluations of behavioral and public health interventions: the TREND statement
    Don C Des Jarlais
    Baron Edmond de Rothschild Chemical Dependency Institute, Beth Israel Medical Center, New York City, USA
    Am J Public Health 94:361-6. 2004
    ..These guidelines emphasize the reporting of theories used and descriptions of intervention and comparison conditions, research design, and methods of adjusting for possible biases in evaluation studies that use nonrandomized designs...
  92. ncbi Mapping of quantitative trait loci affecting quality and production traits in egg layers
    M Tuiskula-Haavisto
    Animal Production Research, Animal Breeding, MTT Agrifood Research Finland, Jokioinen
    Poult Sci 81:919-27. 2002
    ..The most significant QTL explains 25.8% of the phenotypic variance in F2 of body weight. An area affecting the age at first egg, egg weight, and the number of eggs was located on chromosome Z...
  93. pmc Gene expression profiles from formalin fixed paraffin embedded breast cancer tissue are largely comparable to fresh frozen matched tissue
    Lorenza Mittempergher
    Divisions of Experimental Therapy, Molecular Biology, Surgical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    PLoS ONE 6:e17163. 2011
    ..To this end we profiled, in duplicate, 20 FFPE tissues and 20 matched FF tissues and evaluated the concordance of the DASL results from FFPE and matched FF material...
  94. doi Dried tube specimens: a simple and cost-effective method for preparation of HIV proficiency testing panels and quality control materials for use in resource-limited settings
    Bharat S Parekh
    International Laboratory Branch, Division of Global AIDS, Centers for Disease Control and Prevention, Atlanta, GA 30345, USA
    J Virol Methods 163:295-300. 2010
    ..Traditional PT programs and quality control reagents use serum or plasma specimens requiring stringent conditions for storage and transportation...
  95. pmc Quantitative expression profiling in formalin-fixed paraffin-embedded samples by affymetrix microarrays
    Diana Abdueva
    Department of Pathology, Children s Hospital Los Angeles, Research Institute and Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    J Mol Diagn 12:409-17. 2010
    ..This study provides guidelines for application of these methods in the discovery, validation, and clinical application of microarray expression profiling with FFPE material...
  96. ncbi Protein extraction from formalin-fixed, paraffin-embedded tissue sections: quality evaluation by mass spectrometry
    Shan Rong Shi
    Department of Pathology, University of Southern California Keck School of Medicine HMR 204, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    J Histochem Cytochem 54:739-43. 2006
    ....
  97. pmc k-Nearest neighbor models for microarray gene expression analysis and clinical outcome prediction
    R M Parry
    Biomedical Engineering Department, Georgia Institute of Technology and Emory University, Atlanta, GA, USA
    Pharmacogenomics J 10:292-309. 2010
    ..appealing, large performance variations were found among experienced data analysis teams in the MicroArray Quality Control Phase II (MAQC-II) project...
  98. ncbi Comparison of three management strategies for patients with atypical squamous cells of undetermined significance: baseline results from a randomized trial
    D Solomon
    Breast and Gynecologic Cancer Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    J Natl Cancer Inst 93:293-9. 2001
    ..Effective colposcopy triage strategies are needed to identify the minority of women who have clinically significant disease while avoiding excessive follow-up evaluation for others...
  99. doi The World Health Organization African region laboratory accreditation process: improving the quality of laboratory systems in the African region
    Guy Michel Gershy-Damet
    Regional Program on AIDS, Inter Country Support Team West Africa, World Health Organization Regional Office for Africa, Ouagadougou 03, Burkina Faso
    Am J Clin Pathol 134:393-400. 2010
    ..We believe that the WHO-AFRO approach for laboratory accreditation is affordable, sustainable, effective, and scalable...
  100. doi Online verification of human cell line identity by STR DNA typing
    Wilhelm G Dirks
    DSMZ Deutsche Sammlung von Mikroorganismen und Zellkulturen, Braunschweig, Germany
    Methods Mol Biol 731:45-55. 2011
    ..nibio.go.jp/cellbank_e.html , http://www.dsmz.de/STRanalysis ). The following sections describe a rapid, practical, inexpensive, and reliable method available to students, technicians, and scientists...
  101. pmc Effect of open peer review on quality of reviews and on reviewers' recommendations: a randomised trial
    S van Rooyen
    BMJ Editorial, BMA House, London WC1H 9JR, UK
    BMJ 318:23-7. 1999
    ..To examine the effect on peer review of asking reviewers to have their identity revealed to the authors of the paper...

Research Grants97

  1. Cardiac Physiology and Imaging Core for Mouse in Vivo
    Kirk Peterson; Fiscal Year: 2009
    ..He also is experienced in data quality control, data analysis, development of animal models, and experimental design. Jeff Omens, Ph.D...
  2. Tissue Culture Laboratory
    Joseph Goldstein; Fiscal Year: 2009
    ..We have learned that certain aspects of quality control are essential in obtaining reproducible results for metabolic experiments in tissue culture cells...
  3. Latin American Center for Malaria Research and Control
    SOCRATES HERRERA VALENCIA; Fiscal Year: 2010
    ..The study team will provide technical assistance for helping NMCPs improve surveillance operations, including quality control and assurance of data with respect to diagnostics...
  4. Plasmodium Genus and P. falciparum - P. vivax FISH Assays
    Jyotsna Shah; Fiscal Year: 2009
    ..In Phase I, we optimized the fixation and hybridization conditions and set up Quality Control Procedures for the FISH assays...
  5. Research and Development of a Novel System to Produce Polysaccharide Conjugate Va
    Peng George Wang; Fiscal Year: 2012
    ..glycoconjugate vaccines for the clinical use, it still suffers variable batch-to-batch composition, difficult quality control, inconsistent potency and high production cost...
  6. ROBBINS Glycosylation and Glycosidases-Cell and Molecular Biology
    Phillips W Robbins; Fiscal Year: 2010
    ..while the truncated N-glycan precursors of Entamoeba and Trichomonas are sufficient for N- glycan-dependent quality control (QC) of protein folding, N-glycan-dependent QC is absent from Giardia and Plasmodium...
  7. ROBBINS Glycosylation and Glycosidases-Cell and Molecular Biology
    PHILLIPS ROBBINS; Fiscal Year: 2009
    ..while the truncated N-glycan precursors of Entamoeba and Trichomonas are sufficient for N- glycan-dependent quality control (QC) of protein folding, N-glycan-dependent QC is absent from Giardia and Plasmodium...
  8. Production of a Lung Surfactant SP-B Mimic
    Gary Fujii; Fiscal Year: 2009
    ....
  9. Photonic Crystal Surfaces for Label-Free Detection and Fluorescence Amplification
    Brian Cunningham; Fiscal Year: 2009
    ..we describe how replacement of the glass surface with a special-purpose optical transducer can provide quality control information on the interspot and intraspot density of microarray spots that is currently completely lacking ..
  10. Photonic Crystal Surfaces for Label-Free Detection and Fluorescence Amplification
    LILA OTT VODKIN; Fiscal Year: 2010
    ..we describe how replacement of the glass surface with a special-purpose optical transducer can provide quality control information on the interspot and intraspot density of microarray spots that is currently completely lacking ..
  11. Photonic Crystal Surfaces for Label-Free Detection and Fluorescence Amplification
    Brian Cunningham; Fiscal Year: 2009
    ..we describe how replacement of the glass surface with a special-purpose optical transducer can provide quality control information on the interspot and intraspot density of microarray spots that is currently completely lacking ..
  12. BIOCHEMISTRY OF PRE-MRNA SPLICING
    ADRIAN KRAINER; Fiscal Year: 2009
    ..The proposed studies are aimed at understanding basic cellular mechanisms of gene expression, and may provide the basis for developing or improving diagnostic tools and therapeutic agents for these diseases. ..
  13. BIOCHEMISTRY OF PRE-MRNA SPLICING
    ADRIAN KRAINER; Fiscal Year: 2007
    ..The proposed studies are aimed at understanding basic cellular mechanisms of gene expression, and may provide the basis for developing or improving diagnostic tools and therapeutic agents for these diseases. ..
  14. DEVELOPMENT OF AN IMPLANTABLE EMG MICRO-TELEMETER
    DAVID EDELL; Fiscal Year: 2006
    ..e. wrist, thumb, fingers) could be accomplished if multiple sources of high quality control signals were available...
  15. DEVELOPMENT OF AN IMPLANTABLE EMG MICRO-TELEMETER
    DAVID EDELL; Fiscal Year: 2005
    ..e. wrist, thumb, fingers) could be accomplished if multiple sources of high quality control signals were available...
  16. Replication of Association Signals Identified in Ulcerative Colitis GWAS
    Richard H Duerr; Fiscal Year: 2010
    ..ulcerative colitis GWAS using Illumina genotyping beadchip data from 977 cases and 2,122 controls that passed quality control and were matched, by gender and ancestry...
  17. Replication of Association Signals Identified in Ulcerative Colitis GWAS
    Richard Duerr; Fiscal Year: 2009
    ..ulcerative colitis GWAS using Illumina genotyping beadchip data from 977 cases and 2,122 controls that passed quality control and were matched, by gender and ancestry...
  18. BIOCHEMISTRY OF PRE-MRNA SPLICING
    Adrian R Krainer; Fiscal Year: 2010
    ..The proposed studies are aimed at understanding basic cellular mechanisms of gene expression, and may provide the basis for developing or improving diagnostic tools and therapeutic agents for these diseases. ..
  19. Simian Virus 40 (SV40) uncoating and penetration
    Daniel Hebert; Fiscal Year: 2009
    ..The ER also possesses a quality control activity that ensures that only properly folded and assembled proteins are exported through the secretory ..
  20. A Screen for Small Molecule Compounds that Inhibit Bacterial Toxins
    David Haslam; Fiscal Year: 2007
    ..This recently discovered pathway likely represents a recycling and cellular quality control mechanism that has as yet been poorly characterized...
  21. Proteasome, protein oxidation, and cardiomyocyte function.
    SAUL POWELL; Fiscal Year: 2009
    ..Given the major role that proteasome plays in protein quality control and removal of oxidized/damaged proteins, it seems reasonable to suggest that one consequence of proteasome ..
  22. Proteasome, protein oxidation, and cardiomyocyte function.
    Xuejun Wang; Fiscal Year: 2010
    ..Given the major role that proteasome plays in protein quality control and removal of oxidized/damaged proteins, it seems reasonable to suggest that one consequence of proteasome ..
  23. A Phase l Study of Pyrimethamine in patients with GM-2 Gangliosidosis
    Bijan Almassian; Fiscal Year: 2007
    ..to obtain and/or retain its native 3-dimensional fold in the endoplasmic reticulum (ER) where intracellular quality control is performed to retain and degrade defective enzymes...
  24. Autophagy and protein translation in neural function & neurodegeneration
    Albert La Spada; Fiscal Year: 2009
    ..autophagy maintains normal cellular function by degrading aggregate-prone proteins and by supporting protein quality control. Reduced TOR signaling, imposed by rapamycin or dietary restriction, can delay neurological disease onset and ..
  25. Autophagy and protein translation in neural function & neurodegeneration
    Albert R La Spada; Fiscal Year: 2010
    ..autophagy maintains normal cellular function by degrading aggregate-prone proteins and by supporting protein quality control. Reduced TOR signaling, imposed by rapamycin or dietary restriction, can delay neurological disease onset and ..
  26. Myocyte signaling and the response to stress
    WINSTON C PATTERSON; Fiscal Year: 2010
    ..by our laboratory in 1999, and we have recently shown that this protein has a key role in regulating protein quality control in the setting of cellular and physiologic stress, such as myocardial infarction...
  27. Delayed Rectifier K Channel Biogenesis is Unveiled in Models of Long QT Syndrome
    BRIAN DELISLE; Fiscal Year: 2009
    ..that hypothesis: The ER retention of LQT1 and LQT2 mutations is regulated by different components of cellular quality control, and Kv7.1 and Kv11.1 traffic in distinct vesicular transport pathways...
  28. Delayed Rectifier K Channel Biogenesis is Unveiled in Models of Long QT Syndrome
    BRIAN DELISLE; Fiscal Year: 2009
    ..that hypothesis: The ER retention of LQT1 and LQT2 mutations is regulated by different components of cellular quality control, and Kv7.1 and Kv11.1 traffic in distinct vesicular transport pathways...
  29. 2012 Intrinsically Disordered Proteins Gordon Research Conference
    Rohit V Pappu; Fiscal Year: 2012
    ..such as transcriptional regulation, signal transduction, protein trafficking, protein homeostasis and quality control. Most biological functions are based on molecular recognition and complex networks are organized around a ..
  30. Bioassay Guided Isolation of Hypoglycemic Compounds from Philippine Medicinal Pla
    Leah Tolosa; Fiscal Year: 2010
    ..The latter will provide a means of fact-based quality control of herbal medicines that at present is not always available even in the US...
  31. Bioassay Guided Isolation of Hypoglycemic Compounds from Philippine Medicinal Pla
    Leah Tolosa; Fiscal Year: 2011
    ..The latter will provide a means of fact-based quality control of herbal medicines that at present is not always available even in the US...
  32. Screening for Inhibitors of the Integrated Stress Response
    David Ron; Fiscal Year: 2007
    ..the ER can have important pathophysiological consequences: For example, evidence suggests that loosening the quality control in the ER might allow mildly misfolded proteins that are otherwise functional to escape ER retention and ..
  33. Neonatal Chest Phantom for Computed Radiography Testing
    Steven Don; Fiscal Year: 2005
    ..to reduce the risk of induced malignancy from radiation exposure, In practice this requires a rigorous quality control process for clinical operations in radiology...
  34. Disruption of Cellular Messenger RNA Processing Events by the Kaposi's Sarcoma-As
    Britt A Glaunsinger; Fiscal Year: 2010
    ..the nascent hyperadenylated cellular mRNAs are not exported, and we predict they are destroyed by cellular quality control mechanisms...
  35. Neonatal Chest Phantom for Computed Radiography Testing
    Steven Don; Fiscal Year: 2006
    ..to reduce the risk of induced malignancy from radiation exposure, In practice this requires a rigorous quality control process for clinical operations in radiology...
  36. TRANSIENT GLUCOSYLATION OF GLYCOPROTEINS
    Armando Parodi; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The quality control (QC) of glycoprotein folding in the endoplasmic reticulum (ER) involves the interplay of a glucosyltransferase (GT) that only glycosylates not properly folded glycoprotein ..
  37. PROTEIN QUALITY CONTROL IN THE ENDOPLASMIC RETICULUM
    KARL WITTRUP; Fiscal Year: 1999
    ..abstract]: Misfolded and unassembled proteins are retained in the endoplasmic reticulum via a process termed "quality control," ensuring that only native proteins are secreted to the extracellular space...
  38. PROTEIN QUALITY CONTROL IN THE ENDOPLASMIC RETICULUM
    KARL WITTRUP; Fiscal Year: 2000
    ..abstract]: Misfolded and unassembled proteins are retained in the endoplasmic reticulum via a process termed "quality control," ensuring that only native proteins are secreted to the extracellular space...
  39. PROTEIN QUALITY CONTROL IN THE ENDOPLASMIC RETICULUM
    KARL WITTRUP; Fiscal Year: 1999
    ..abstract]: Misfolded and unassembled proteins are retained in the endoplasmic reticulum via a process termed "quality control," ensuring that only native proteins are secreted to the extracellular space...
  40. PROTEIN QUALITY CONTROL IN THE ENDOPLASMIC RETICULUM
    KARL WITTRUP; Fiscal Year: 2001
    ..abstract]: Misfolded and unassembled proteins are retained in the endoplasmic reticulum via a process termed "quality control," ensuring that only native proteins are secreted to the extracellular space...
  41. Biostatistics and Data Management
    Helaine Resnick; Fiscal Year: 2007
    ..These systems will include numerous quality control features, as well as randomization functions for appropriate projects...
  42. The role of mitochondria-associated RING finger proteins in mitochondrial quality
    Mariusz Karbowski; Fiscal Year: 2009
    ..However, despite their importance, the mechanisms of mitochondrial quality control, as well as the signaling mechanisms between mitochondria and other cell compartments, are largely unknown...
  43. The role of mitochondria-associated RING finger proteins in mitochondrial quality
    Mariusz Karbowski; Fiscal Year: 2010
    ..However, despite their importance, the mechanisms of mitochondrial quality control, as well as the signaling mechanisms between mitochondria and other cell compartments, are largely unknown...
  44. The role of mitochondria-associated RING finger proteins in mitochondrial quality
    Mariusz Karbowski; Fiscal Year: 2009
    ..However, despite their importance, the mechanisms of mitochondrial quality control, as well as the signaling mechanisms between mitochondria and other cell compartments, are largely unknown...
  45. TRANSIENT GLUCOSYLATION OF GLYCOPROTEINS
    Armando Parodi; Fiscal Year: 2004
    The quality control of glycoprotein folding in the endoplasmic reticulum (ER) involves the interplay of a glucosyltransferase (GT) that only glycosylates not properly folded protein conformers, glucosidase lI (GII) that removes residues ..
  46. TRANSIENT GLUCOSYLATION OF GLYCOPROTEINS
    Armando Parodi; Fiscal Year: 2007
    The quality control of glycoprotein folding in the endoplasmic reticulum (ER) involves the interplay of a glucosyltransferase (GT) that only glycosylates not properly folded protein conformers, glucosidase lI (GII) that removes residues ..
  47. TRANSIENT GLUCOSYLATION OF GLYCOPROTEINS
    Armando Parodi; Fiscal Year: 2006
    The quality control of glycoprotein folding in the endoplasmic reticulum (ER) involves the interplay of a glucosyltransferase (GT) that only glycosylates not properly folded protein conformers, glucosidase lI (GII) that removes residues ..
  48. TRANSIENT GLUCOSYLATION OF GLYCOPROTEINS
    Armando Parodi; Fiscal Year: 2005
    The quality control of glycoprotein folding in the endoplasmic reticulum (ER) involves the interplay of a glucosyltransferase (GT) that only glycosylates not properly folded protein conformers, glucosidase lI (GII) that removes residues ..
  49. Metabolomics-Measured Urinary Metabolites, Diet & BP, 17 Population Samples: INTE
    Jeremiah Stamler; Fiscal Year: 2007
    ..2 from each of the 4, 680 participants plus 10% randomly selected, blinded split specimens for external quality control)...
  50. Metabolomics-Measured Urinary Metabolites, Diet & BP, 17 Population Samples: INTE
    Jeremiah Stamler; Fiscal Year: 2010
    ..2 from each of the 4, 680 participants plus 10% randomly selected, blinded split specimens for external quality control)...
  51. Metabolomics-Measured Urinary Metabolites, Diet & BP, 17 Population Samples: INTE
    Jeremiah Stamler; Fiscal Year: 2009
    ..2 from each of the 4, 680 participants plus 10% randomly selected, blinded split specimens for external quality control)...
  52. CELLULAR PROTEIN MATURATION AND DEGRADATION
    Daniel Hebert; Fiscal Year: 1999
    The overall goal of this proposal is to understand the biological processes involved in the protein folding, quality control and degradation of the membrane glycoprotein tyrosinase...
  53. CELLULAR PROTEIN MATURATION AND DEGRADATION
    Daniel Hebert; Fiscal Year: 2003
    The overall goal of this proposal is to understand the biological processes involved in the protein folding, quality control and degradation of the membrane glycoprotein tyrosinase...
  54. CELLULAR PROTEIN MATURATION AND DEGRADATION
    Daniel Hebert; Fiscal Year: 2002
    The overall goal of this proposal is to understand the biological processes involved in the protein folding, quality control and degradation of the membrane glycoprotein tyrosinase...
  55. CELLULAR PROTEIN MATURATION AND DEGRADATION
    Daniel Hebert; Fiscal Year: 2000
    The overall goal of this proposal is to understand the biological processes involved in the protein folding, quality control and degradation of the membrane glycoprotein tyrosinase...
  56. CELLULAR PROTEIN MATURATION AND DEGRADATION
    Daniel Hebert; Fiscal Year: 2001
    The overall goal of this proposal is to understand the biological processes involved in the protein folding, quality control and degradation of the membrane glycoprotein tyrosinase...
  57. Role of ER-Localized Chaperones in Toxin Pathogenesis
    David Haslam; Fiscal Year: 2005
    ..This recently discovered pathway from the endoplasmic reticulum lumen to the cytoplasm represents a cellular quality control mechanism responsible for degrading host proteins that misfold in the ER lumen (termed ER-associated ..
  58. Role of ER-Localized Chaperones in Toxin Pathogenesis
    David Haslam; Fiscal Year: 2004
    ..This recently discovered pathway from the endoplasmic reticulum lumen to the cytoplasm represents a cellular quality control mechanism responsible for degrading host proteins that misfold in the ER lumen (termed ER-associated ..
  59. Role of ER-Localized Chaperones in Toxin Pathogenesis
    David Haslam; Fiscal Year: 2003
    ..This recently discovered pathway from the endoplasmic reticulum lumen to the cytoplasm represents a cellular quality control mechanism responsible for degrading host proteins that misfold in the ER lumen (termed ER-associated ..
  60. ER-Localized Chaperones in Toxin Pathogenesis
    David Haslam; Fiscal Year: 2002
    ..This recently discovered pathway from the endoplasmic reticulum lumen to the cytoplasm represents a cellular quality control mechanism responsible for degrading host proteins that misfold in the ER lumen (termed ER-associated ..
  61. Role of ER-Localized Chaperones in Toxin Pathogenesis
    David Haslam; Fiscal Year: 2006
    ..This recently discovered pathway from the endoplasmic reticulum lumen to the cytoplasm represents a cellular quality control mechanism responsible for degrading host proteins that misfold in the ER lumen (termed ER-associated ..
  62. DATA COORDINATING CENTER FOR INTERSTITIAL CYSTITIS
    J Landis; Fiscal Year: 1992
    ..the DCC will develop and implement a data and patient specimen collection system, assure quality control and provide appropriate detailed data reports to the Steering Committee and to the External Advisory ..
  63. Innovative Systems & Educational Tools to Advance an Established Diabetic Retinop
    GARY GREGORY; Fiscal Year: 2009
    ..It features a validated robust telemedicine platform with sophisticated, quality control oversight and expert evaluation...
  64. Implementation of innovative RNA sample quality control methods
    JAMES C contact WILLEY; Fiscal Year: 2010
    ..Further, use of existing banks of biospecimens with variable RNA quality is limited due to inadequate RNA quality control (QC) measurement methods...
  65. Quality Control of Protein Translation
    A Wali Karzai; Fiscal Year: 2009
    ..One of the most fascinating quality control mechanisms involves tmRNA, also known as SsrA or 10Sa RNA...
  66. CELLULAR PROTEIN MATURATION AND DEGRADATION
    Daniel Hebert; Fiscal Year: 2004
    The overall goal of this proposal is to elucidate the role of N-linked glycans in the maturation and quality control of proteins that traverse the secretory pathway...
  67. CELLULAR PROTEIN MATURATION AND DEGRADATION
    Daniel Hebert; Fiscal Year: 2007
    ..The overall goal of this proposal is to elucidate the role of N-linked glycans in the maturation and quality control of proteins that traverse the secretory pathway...
  68. CELLULAR PROTEIN MATURATION AND DEGRADATION
    Daniel Hebert; Fiscal Year: 2006
    ..The overall goal of this proposal is to elucidate the role of N-linked glycans in the maturation and quality control of proteins that traverse the secretory pathway...
  69. CELLULAR PROTEIN MATURATION AND DEGRADATION
    Daniel Hebert; Fiscal Year: 2005
    The overall goal of this proposal is to elucidate the role of N-linked glycans in the maturation and quality control of proteins that traverse the secretory pathway...
  70. The functions and mechanism of SHSP degradation in Escherichia coli
    Ellen Kloss; Fiscal Year: 2010
    ..This work will help define the role of sHSPs and sHSP turnover in the larger protein-quality control network. Finally, how sHSPs are recognized by proteases is unknown...
  71. 2010 Cold Spring Harbor Laboratory Conference on Molecular Chaperones and Stress
    David J Stewart; Fiscal Year: 2010
    ..between protein folding and proteolysis mediated by chaperones, (5) how the various protein folding and quality control systems in a cell function together to provide a robust protein folding environment and how the breakdown of ..
  72. Quality control mechanisms against misfolded rhodopsins in Drosophila.
    HYUNG D RYOO; Fiscal Year: 2010
    ..As most cells have robust quality control mechanisms that can help eliminate such misfolded proteins from the ER, a better understanding of these ..
  73. Resuscitation Outcomes Consortium (ROC) Data Coordinating Center
    Gerald van Belle; Fiscal Year: 2010
    ..and improve an efficient and secure information technology system for collection, processing, storage, and quality control of the data...
  74. Resuscitation Outcomes Consortium (ROC) Data Coordinating Center
    Gerald van Belle; Fiscal Year: 2010
    ..and improve an efficient and secure information technology system for collection, processing, storage, and quality control of the data...
  75. Resuscitation Outcomes Consortium (ROC) Data Coordinating Center
    Gerald van Belle; Fiscal Year: 2010
    ..and improve an efficient and secure information technology system for collection, processing, storage, and quality control of the data...
  76. TREATMENT OF PANIC DISORDER--LONG TERM STRATEGIES
    Scott Woods; Fiscal Year: 2001
    ..began somewhat later than we predicted because of rigorous attention to state-of-the-art assessment and quality control procedures. Careful thought about essential assessment domains appears to have been well worth the effort...
  77. TREATMENT OF PANIC DISORDER--LONG TERM STRATEGIES
    Scott Woods; Fiscal Year: 2002
    ..began somewhat later than we predicted because of rigorous attention to state-of-the-art assessment and quality control procedures. Careful thought about essential assessment domains appears to have been well worth the effort...
  78. TREATMENT OF PANIC DISORDER--LONG TERM STRATEGIES
    Scott Woods; Fiscal Year: 2003
    ..began somewhat later than we predicted because of rigorous attention to state-of-the-art assessment and quality control procedures. Careful thought about essential assessment domains appears to have been well worth the effort...
  79. TREATMENT OF PANIC DISORDER--LONG TERM STRATEGIES
    Scott Woods; Fiscal Year: 2000
    ..began somewhat later than we predicted because of rigorous attention to state-of-the-art assessment and quality control procedures. Careful thought about essential assessment domains appears to have been well worth the effort...
  80. DATA ACQUISITION & ANALYSIS CTR FOR BEHAVIORAL RESEARCH
    Tyler Hartwell; Fiscal Year: 1999
    ..in refining and developing the study materials; to develop and implement data collection systems; to oversee quality control; to conduct training of site staff; to prepare periodic reports for the Steering Committee; to develop and ..
  81. TREATMENT OF PANIC DISORDER--LONG TERM STRATEGIES
    Jack Gorman; Fiscal Year: 2000
    ..began somewhat later than we predicted because of rigorous attention to state-of-the -art assessment and quality control procedures. Careful thought about essential assessment domains appears to have been well worth the effort...
  82. TREATMENT OF PANIC DISORDER--LONG TERM STRATEGIES
    Jack Gorman; Fiscal Year: 2001
    ..began somewhat later than we predicted because of rigorous attention to state-of-the -art assessment and quality control procedures. Careful thought about essential assessment domains appears to have been well worth the effort...
  83. TREATMENT OF PANIC DISORDER--LONG TERM STRATEGIES
    Jack Gorman; Fiscal Year: 2002
    ..began somewhat later than we predicted because of rigorous attention to state-of-the -art assessment and quality control procedures. Careful thought about essential assessment domains appears to have been well worth the effort...
  84. TREATMENT OF PANIC DISORDER--LONG TERM STRATEGIES
    Jack Gorman; Fiscal Year: 2003
    ..began somewhat later than we predicted because of rigorous attention to state-of-the -art assessment and quality control procedures. Careful thought about essential assessment domains appears to have been well worth the effort...
  85. ABCA3 and the Response to Lung Injury
    RASHMIN SAVANI; Fiscal Year: 2009
    ..When this quality control system is overwhelmed, mutant protein accumulates in the ER and triggers the activation/expression of stress ..
  86. U10 APPLICATION CALCB SURGICAL MODALITY COMMITTEE
    David Sugarbaker; Fiscal Year: 1993
    ..Among the major functions of the Surgery Modality Committee will be to implement a comprehensive quality control and quality assurance program, which will be applied to all protocols which employ surgery...
  87. ABCA3 and the Response to Lung Injury
    RASHMIN SAVANI; Fiscal Year: 2009
    ..When this quality control system is overwhelmed, mutant protein accumulates in the ER and triggers the activation/expression of stress ..
  88. CYTOSOLIC GLYCOSYLATION
    Christopher West; Fiscal Year: 2003
    ..evidence for Skp 1-enzyme interactions, we hypothesize that the Skp1 modification pathway has chaperone/quality control activity that facilitates and monitors folding of Skp1 for entry into the SCF complex and ultimately the ..
  89. CYTOSOLIC GLYCOSYLATION
    Christopher West; Fiscal Year: 2004
    ..evidence for Skp 1-enzyme interactions, we hypothesize that the Skp1 modification pathway has chaperone/quality control activity that facilitates and monitors folding of Skp1 for entry into the SCF complex and ultimately the ..
  90. Proteostasis sensors to assess the cellular protein folding capacity
    RICHARD MORIMOTO; Fiscal Year: 2009
    ..The long-term health of all metazoan cells is inextricably linked to protein quality control. This is achieved by proteostasis, a complex network of molecular interactions that determines the health of ..
  91. CYTOSOLIC GLYCOSYLATION
    Christopher West; Fiscal Year: 2003
    ..evidence for Skp 1-enzyme interactions, we hypothesize that the Skp1 modification pathway has chaperone/quality control activity that facilitates and monitors folding of Skp1 for entry into the SCF complex and ultimately the ..
  92. CYTOSOLIC GLYCOSYLATION
    Christopher West; Fiscal Year: 2005
    ..evidence for Skp 1-enzyme interactions, we hypothesize that the Skp1 modification pathway has chaperone/quality control activity that facilitates and monitors folding of Skp1 for entry into the SCF complex and ultimately the ..
  93. Proteostasis sensors to assess the cellular protein folding capacity
    RICHARD I contact MORIMOTO; Fiscal Year: 2010
    ..The long-term health of all metazoan cells is inextricably linked to protein quality control. This is achieved by proteostasis, a complex network of molecular interactions that determines the health of ..
  94. CYTOSOLIC GLYCOSYLATION
    Christopher West; Fiscal Year: 2002
    ..evidence for Skp 1-enzyme interactions, we hypothesize that the Skp1 modification pathway has chaperone/quality control activity that facilitates and monitors folding of Skp1 for entry into the SCF complex and ultimately the ..
  95. Glycosylation of Thrombospondin Type 1 Repeats
    Robert S Haltiwanger; Fiscal Year: 2010
    ..Recent studies show that Pofutl is localized to the ER and may participate in quality control of EGF repeat folding...
  96. PATHOBIOGENESIS OF HERITABLE PULMONARY EMPHYSEMA
    Richard Sifers; Fiscal Year: 2000
    ..recognized that by "silencing" the posttranslational expression of mutant gene products, conformation-based quality control functions as a common basis for a diverse set of heritable pathologic conditions, each of which is caused by ..