miniaturization

Summary

Summary: The design or construction of objects greatly reduced in scale.

Top Publications

  1. ncbi Optical-transparent and flexible glucose sensor with ITO electrode
    Kohji Mitsubayashi
    Department of Human and Information Science, School of Engineering, Tokai University, 1117 Kitakaname, Hiratsuka, Kanagawa 259 1292, Japan
    Biosens Bioelectron 19:67-71. 2003
  2. ncbi Point-of-care testing and molecular diagnostics: miniaturization required
    Frederick L Kiechle
    Department of Pathology, Pathology Consultants of South Broward, LLP, Memorial Regional Hospital, Hollywood, FL 33021, USA
    Clin Lab Med 29:555-60. 2009
  3. ncbi Miniaturization of nervous systems and neurons
    Jeremy E Niven
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Curr Biol 22:R323-9. 2012
  4. pmc High-speed, miniaturized fluorescence microscopy in freely moving mice
    Benjamin A Flusberg
    James H Clark Center for Biomedical Engineering and Sciences, Stanford University, 318 Campus Drive, Stanford, California 94305, USA
    Nat Methods 5:935-8. 2008
  5. pmc Compact, light-weight and cost-effective microscope based on lensless incoherent holography for telemedicine applications
    Onur Mudanyali
    Electrical Engineering Department, University of California, Los Angeles, CA 90095, USA
    Lab Chip 10:1417-28. 2010
  6. ncbi Droplet-based microfluidic platforms for the encapsulation and screening of Mammalian cells and multicellular organisms
    Jenifer Clausell-Tormos
    Institut de Science et d Ingenierie Supramoleculaires, Universite Louis Pasteur, Strasbourg Cedex, France
    Chem Biol 15:427-37. 2008
  7. ncbi Refractive index sensing based on higher-order mode reflection of a microfiber Bragg grating
    Yu Zhang
    Wuhan National Laboratory for Optoelectronics and Institute of Optoelectronics Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
    Opt Express 18:26345-50. 2010
  8. ncbi The use of microimplants in orthodontic anchorage
    Chung Ho Chen
    Department of Oral and Maxillofacial Surgery, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Oral Maxillofac Surg 64:1209-13. 2006
  9. ncbi Integrating whole transcriptome assays on a lab-on-a-chip for single cell gene profiling
    N Bontoux
    Laboratoire de Neurobiologie et Diversité Cellulaire, CNRS UMR 7637, ESPCI, Paris Cedex 05, France
    Lab Chip 8:443-50. 2008
  10. ncbi Supported microfiber loops for optical sensing
    Xin Guo
    Department of Optical Engineering, State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, China
    Opt Express 16:14429-34. 2008

Detail Information

Publications293 found, 100 shown here

  1. ncbi Optical-transparent and flexible glucose sensor with ITO electrode
    Kohji Mitsubayashi
    Department of Human and Information Science, School of Engineering, Tokai University, 1117 Kitakaname, Hiratsuka, Kanagawa 259 1292, Japan
    Biosens Bioelectron 19:67-71. 2003
    ..The sensor was possible to be used for measuring glucose from 0.06 to 1.24 mmol/l (correlation coefficient: 0.999), including the reported concentration of tear glucose in normal (0.14 mmol/l), with good reproducibility...
  2. ncbi Point-of-care testing and molecular diagnostics: miniaturization required
    Frederick L Kiechle
    Department of Pathology, Pathology Consultants of South Broward, LLP, Memorial Regional Hospital, Hollywood, FL 33021, USA
    Clin Lab Med 29:555-60. 2009
    ..The creation of such a device requires miniaturization of current technologies and the use of microfluidics, microarrays, and small-diameter capillary tubes to ..
  3. ncbi Miniaturization of nervous systems and neurons
    Jeremy E Niven
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Curr Biol 22:R323-9. 2012
    ..Despite these adaptations, we argue that limitations on information processing are likely to affect the behaviour generated by miniaturized nervous systems...
  4. pmc High-speed, miniaturized fluorescence microscopy in freely moving mice
    Benjamin A Flusberg
    James H Clark Center for Biomedical Engineering and Sciences, Stanford University, 318 Campus Drive, Stanford, California 94305, USA
    Nat Methods 5:935-8. 2008
    ..We describe a miniaturized (1.1 g mass) epifluorescence microscope for cellular-level brain imaging in freely moving mice, and its application to imaging microcirculation and neuronal Ca(2+) dynamics...
  5. pmc Compact, light-weight and cost-effective microscope based on lensless incoherent holography for telemedicine applications
    Onur Mudanyali
    Electrical Engineering Department, University of California, Los Angeles, CA 90095, USA
    Lab Chip 10:1417-28. 2010
    ....
  6. ncbi Droplet-based microfluidic platforms for the encapsulation and screening of Mammalian cells and multicellular organisms
    Jenifer Clausell-Tormos
    Institut de Science et d Ingenierie Supramoleculaires, Universite Louis Pasteur, Strasbourg Cedex, France
    Chem Biol 15:427-37. 2008
    ..However, further miniaturization of conventional microtiter plate technology is problematic due to evaporation and capillary action...
  7. ncbi Refractive index sensing based on higher-order mode reflection of a microfiber Bragg grating
    Yu Zhang
    Wuhan National Laboratory for Optoelectronics and Institute of Optoelectronics Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
    Opt Express 18:26345-50. 2010
    ..The measured maximum sensitivity is ~102 nm/RIU (RI unit) at an RI value of 1.378 in an MFBG with a diameter of 6 μm...
  8. ncbi The use of microimplants in orthodontic anchorage
    Chung Ho Chen
    Department of Oral and Maxillofacial Surgery, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Oral Maxillofac Surg 64:1209-13. 2006
    ..The aim of this study is to determine the incidence of anchor retention after orthodontic force application for moving teeth, and to determine the relationship of microimplant length to retention rate...
  9. ncbi Integrating whole transcriptome assays on a lab-on-a-chip for single cell gene profiling
    N Bontoux
    Laboratoire de Neurobiologie et Diversité Cellulaire, CNRS UMR 7637, ESPCI, Paris Cedex 05, France
    Lab Chip 8:443-50. 2008
    ..This demonstrates the outstanding sensitivity of the microfluidic method...
  10. ncbi Supported microfiber loops for optical sensing
    Xin Guo
    Department of Optical Engineering, State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, China
    Opt Express 16:14429-34. 2008
    ..8 x 10(-5)...
  11. ncbi Mechanical stability assessment of novel orthodontic mini-implant designs: Part 2
    Christine Hong
    Section on Orthodontics, University of California, Los Angeles, USA
    Angle Orthod 81:1001-9. 2011
    ..To evaluate the mean buccal bone thickness of maxillary and mandibular posterior teeth using cone-beam computed tomography (CBCT)...
  12. ncbi Miniscrews in orthodontic treatment: review and analysis of published clinical trials
    Adriano G Crismani
    Department of Orthodontics, School of Dentistry, Medical University of Vienna, Vienna, Austria
    Am J Orthod Dentofacial Orthop 137:108-13. 2010
    ..A systematic review of effects related to patient, screw, surgery, and loading on the stability of miniscrews was conducted...
  13. ncbi Impact of bone quality, implant type, and implantation site preparation on insertion torques of mini-implants used for orthodontic anchorage
    B Wilmes
    Department of Orthodontics, University of Duesseldorf, Germany
    Int J Oral Maxillofac Surg 40:697-703. 2011
    ..Compacta thickness, implant design and preparation of implant site affect the insertion torque of mini-implants for orthodontic anchorage. To avoid fractures and high bone stresses, optimum pre-drilling diameters should be chosen...
  14. ncbi Organic photodiodes for biosensor miniaturization
    Jason R Wojciechowski
    Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, DC 20375, USA
    Anal Chem 81:3455-61. 2009
    ..b>Miniaturization of biosensors is essential for use in the field or at the point of care...
  15. ncbi Application and effectiveness of a mini-implant- and tooth-borne rapid palatal expansion device: the hybrid hyrax
    Benedict Wilmes
    Department of Orthodontics, University of Duesseldorf, Duesseldorf, Germany
    World J Orthod 11:323-30. 2010
    ..Because this device is also attached to the first molars, it can be denominated as a bone- and tooth-borne appliance (hybrid hyrax). The objective of this clinical pilot study was to investigate its dental and skeletal effects...
  16. ncbi Diagnostic performance of handheld echocardiography for the assessment of basic cardiac morphology and function: a validation study in routine cardiac patients
    Christian Prinz
    Department of Cardiology, Heart Center North Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany
    Echocardiography 29:887-94. 2012
    ..To investigate the intra- and interrater variability of expert users in the interpretation of handheld echocardiographic studies (HAND)...
  17. pmc Bioprocess control in microscale: scalable fermentations in disposable and user-friendly microfluidic systems
    Matthias Funke
    AVT Biochemical Engineering, RWTH Aachen University, Worringerweg 1, D 52074 Aachen, Germany
    Microb Cell Fact 9:86. 2010
    ..To realize a user-friendly system for routine laboratory work, disposable microfluidic MTPs are utilized which are actuated by a user-friendly pneumatic hardware...
  18. ncbi Evaluation of orthodontic mini-implant anchorage in premolar extraction therapy in adolescents
    Judah S Garfinkle
    Department of Plastic Surgery and Orthodontics, Oregon Health and Science University, Portland, OR 97239, USA
    Am J Orthod Dentofacial Orthop 133:642-53. 2008
    ..The purpose of this study was to determine the success rate, positional stability, and patient evaluation of orthodontic mini-implants (OMIs)...
  19. ncbi Stability comparison between commercially available mini-implants and a novel design: part 1
    Christine Hong
    Section of Orthodontics, UCLA School of Dentistry, Los Angeles, CA 90095, USA
    Angle Orthod 81:692-9. 2011
    ....
  20. ncbi Miniaturization and validation of a sensitive multiparametric cell-based assay for the concomitant detection of microtubule-destabilizing and microtubule-stabilizing agents
    Emilie Vassal
    Universite Joseph Fourier, INSERM U366 CS DRDC CEA Grenoble, France
    J Biomol Screen 11:377-89. 2006
    ..This assay was validated using known compounds. This new cell-based assay represents an alternative to both global cytotoxicity assays and in vitro tubulin assembly assays commonly used for the detection of microtubule poisons...
  21. ncbi Application of microbioreactors in fermentation process development: a review
    Daniel Schäpper
    Department of Chemical and Biochemical Engineering, Technical University of Denmark, 2800, Lyngby, Denmark
    Anal Bioanal Chem 395:679-95. 2009
    ..Current microbioreactor technology is analyzed in this review paper, focusing on its industrial applicability, and directions for future research are presented...
  22. ncbi The use of pocket-size imaging devices: a position statement of the European Association of Echocardiography
    Rosa Sicari
    CNR, Institute of Clinical Physiology, Italy
    Eur J Echocardiogr 12:85-7. 2011
    ..4) The patient has to be informed that an examination with the current generation of pocket-size imaging devices does not replace a complete echocardiogram...
  23. ncbi Miniaturization in functional genomics and proteomics
    Sascha Sauer
    Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, Ihnestrasse 73, D 14195 Berlin, Germany
    Nat Rev Genet 6:465-76. 2005
    ..b>Miniaturization of biological assays is an important prerequisite to achieve these goals in the near future.
  24. ncbi Soft-tissue and cortical-bone thickness at orthodontic implant sites
    Hee Jin Kim
    Division in Anatomy and Developmental Biology, Department of Oral Biology, Oral Science Research Center, Brain Korea 21 Project for Medical Science, Yonsei University, College of Dentistry, Seoul, South Korea
    Am J Orthod Dentofacial Orthop 130:177-82. 2006
    ..To obtain sufficient stability of implants, the thickness of the soft tissue and the cortical bone in the placement site must be considered. However, the literature contains few anatomical studies of orthodontic implants...
  25. ncbi In vivo fiber-optic confocal reflectance microscope with an injection-molded plastic miniature objective lens
    Kristen Carlson
    Department of Biomedical Engineering, The University of Texas at Austin, 1 University Station, C0800 ENS10, Austin, Texas 78712, USA
    Appl Opt 44:1792-7. 2005
    ..Confocal images of ex vivo cervical tissue biopsies and in vivo human lip taken at 15 frames/s demonstrate the microscope's capability of imaging cell morphology and tissue architecture...
  26. ncbi A fluorescence confocal endomicroscope for in vivo microscopy of the upper- and the lower-GI tract
    Adrian L Polglase
    Cabrini Monash University Department of Surgery, Cabrini Medical Centre, Malvern, Victoria, Australia
    Gastrointest Endosc 62:686-95. 2005
    ..The work assessed the feasibility of performing in vivo microscopy at endoscopic examination and evaluated fluorescence imaging protocols...
  27. ncbi Miniaturization and parallelization of biological and chemical assays in microfluidic devices
    Saurabh Vyawahare
    Microfluidics Laboratory, Physical Sciences Oncology Center, Physics Department, Princeton University, Princeton, NJ 08544, USA
    Chem Biol 17:1052-65. 2010
    Microfluidic systems are an attractive solution for the miniaturization of biological and chemical assays...
  28. ncbi Miniaturization of a high-throughput pLDH-based Plasmodium falciparum growth inhibition assay for small volume samples from preclinical and clinical vaccine trials
    Elke S Bergmann-Leitner
    US Military Malaria Vaccine Program, Division of Malaria Vaccine Development, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
    Am J Trop Med Hyg 78:468-71. 2008
    ..This culture method can be extended beyond the pLDH-based readout to other techniques commonly used to determine growth/invasion inhibition...
  29. ncbi Diagnostic accuracy of a hand-held ultrasound scanner in routine patients referred for echocardiography
    Christian Prinz
    Department of Cardiology, University Hospital Gasthuisberg, Catholic University Leuven, Leuven, Belgium
    J Am Soc Echocardiogr 24:111-6. 2011
    ..The aim of this study was to investigate the imaging capabilities of recent hand-held ultrasound scanners...
  30. ncbi Parameters affecting primary stability of orthodontic mini-implants
    Benedict Wilmes
    Department of Orthodontics, Heinrich Heine Universitat Dusseldorf, Moorenstr 5, 40225, Dusseldorf, Germany
    J Orofac Orthop 67:162-74. 2006
    ..Sufficient primary stability is imperative to minimize implant loss rate. The aim of this study was to quantitatively analyze the factors influencing primary stability: bone quality, implant-design, diameter, and depth of pilot drilling...
  31. ncbi Human serum albumin adsorption study on 62-MHz miniaturized quartz gravimetric sensors
    Ping Kao
    Department of Electrical Engineering, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Anal Chem 80:5930-6. 2008
    ..03 x 10(6) M(-1), which is in agreement with the values reported in the literature. The high sensitivity of the miniaturized QCM devices can be a significant advantage in both vapor and solution adsorption analyses...
  32. ncbi Root proximity is a major factor for screw failure in orthodontic anchorage
    Shingo Kuroda
    Department of Orthodontics and Dentofacial Orthopedics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Am J Orthod Dentofacial Orthop 131:S68-73. 2007
    ..The purpose of this study was to evaluate root proximity as a risk factor for the failure of miniscrews used as orthodontic anchorage...
  33. ncbi Theory and operation of 2-D array piezoelectric micromachined ultrasound transducers
    David E Dausch
    RTI International, Center for Materials and Electronic Technologies, Research Triangle Park, NC, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 55:2484-92. 2008
    ..The pMUT arrays were attached directly to the Duke University T5 Phased Array Scanner to produce real-time pulse-echo B-mode images with the 2-D pMUT arrays...
  34. ncbi Maxillary molar distalization with miniplates assessed on digital models: a prospective clinical trial
    Marie A Cornelis
    Department of Orthodontics, Universite Catholique de Louvain, Brussels, Belgium
    Am J Orthod Dentofacial Orthop 132:373-7. 2007
    ..The purpose of this prospective study was to evaluate the effects of maxillary molar distalization in patients treated with a miniplate skeletal anchorage system...
  35. ncbi A system of miniaturized stirred bioreactors for parallel continuous cultivation of yeast with online measurement of dissolved oxygen and off-gas
    Tobias Klein
    Biochemical Engineering Institute, Saarland University, Campus A1 5, D 66123 Saarbrucken, Germany
    Biotechnol Bioeng 110:535-42. 2013
    ..In all cases, an almost completely closed carbon balance was obtained proving the reliability of the experimental setup...
  36. ncbi Comparison of self-tapping and self-drilling orthodontic mini-implants: an animal study of insertion torque and displacement under lateral loading
    Yu Yu Su
    Department of Orthodontics, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Int J Oral Maxillofac Implants 24:404-11. 2009
    ..The aim of this study was to compare two types of orthodontic mini-implants, self-tapping and self-drilling, by measurement of the insertion torques and the displacements under lateral loading in an animal model...
  37. ncbi Impact of insertion depth and predrilling diameter on primary stability of orthodontic mini-implants
    Benedict Wilmes
    Department of Orthodontics, University of Duessseldorf, Duesseldorf, Germany
    Angle Orthod 79:609-14. 2009
    ..To test the hypothesis that the impact of the insertion depth and predrilling diameter have no effect on the primary stability of mini-implants...
  38. ncbi Effects of circuit miniaturization in reducing inflammatory response to infant cardiopulmonary bypass by elimination of allogeneic blood products
    Edward Hickey
    Division of Pediatric Cardiac Surgery, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
    Ann Thorac Surg 81:S2367-72. 2006
    ..This would suggest an advantage for eliminating blood use in infant cardiopulmonary bypass through circuit miniaturization. In this article, we review the data supporting this rationale and provide the results from studies in our ..
  39. ncbi Effect of screw diameter on orthodontic skeletal anchorage
    Chad Morarend
    Department of Preventive and Community Dentistry, College of Dentistry, University of Iowa, Iowa City 52242, USA
    Am J Orthod Dentofacial Orthop 136:224-9. 2009
    ....
  40. ncbi Microtiter plates as mini-bioreactors: miniaturization of fermentation methods
    Wouter A Duetz
    Enzyscreen, Biopartner Center Leiden, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
    Trends Microbiol 15:469-75. 2007
    ..In this review, I will discuss these fundamental issues and describe the current applications of microtiter plates in microbiology. Microtiter plates can now be considered a mature alternative to Erlenmeyer shake flasks...
  41. ncbi Effects of placement angle and direction of orthopedic force application on the stability of orthodontic miniscrews
    Jihye Lee
    Department of Orthodontics, College of Dentistry, Yonsei University, Seoul, Korea
    Angle Orthod 83:667-73. 2013
    ..To evaluate the influence of placement angle and direction of orthopedic force application on the stability of miniscrews...
  42. ncbi Miniaturization and validation of the Ellman's reaction based acetylcholinesterase inhibitory assay into 384-well plate format and screening of a chemical library
    Päivi P Järvinen
    Division of Pharmaceutical Biology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5E, P O Box 56, FIN 00014, Helsinki, Finland
    Comb Chem High Throughput Screen 13:278-84. 2010
    ..The miniaturized 384-well plate format of the Ellman's method was proven to be robust and to perform reliably...
  43. ncbi Inhibition of a basal transcription factor 3-like gene Osj10gBTF3 in rice results in significant plant miniaturization and typical pollen abortion
    Ya Wang
    Institute of Crop Science, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, PR China
    Plant Cell Physiol 53:2073-89. 2012
    ..Our demonstration of the important role of Osj10gBTF3 in rice growth and development provides new insights showing that more complex regulatory functions are associated with BTF3 in plants...
  44. ncbi Programmable assembly of a metabolic pathway enzyme in a pre-packaged reusable bioMEMS device
    Xiaolong Luo
    Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA
    Lab Chip 8:420-30. 2008
    ..We envision that this assembly strategy can be applied to rebuild metabolic pathways in microfluidic environments for antimicrobial drug discovery...
  45. ncbi Feasibility and clinical implementation of hand-held echocardiography
    Havard Dalen
    Levanger Hospital, Nord Trøndelag Health Trust, Norway
    Expert Rev Cardiovasc Ther 11:49-54. 2013
    ..However, the benefit relies on the level of competence of the users and tailored training is needed to answer specific questions...
  46. pmc A new stoichiometric miniaturization strategy for screening of industrial microbial strains: application to cellulase hyper-producing Trichoderma reesei strains
    Etienne Jourdier
    IFP Energies nouvelles, 1 et 4 Avenue de Bois Préau, 92852 Rueil Malmaison, France
    Microb Cell Fact 11:70. 2012
    ..To ensure an effective high-throughput screening, miniaturized laboratory conditions must mimic industrial conditions, especially for oxygen transfer, feeding capacity and pH stabilization...
  47. ncbi Fast track echo of abdominal aortic aneurysm using a real pocket-ultrasound device at bedside
    Marina Dijos
    Echocardiography Department, University of Bordeaux, Pessac, France
    Echocardiography 29:285-90. 2012
    ..We hypothesized that less expensive ultraportable devices could identify AAA with the same level of accuracy as conventional approaches...
  48. ncbi Biomechanical anchorage evaluation of mini-implants treated with sandblasting and acid etching in orthodontics
    Jorge H Calderón
    Centro de Estudios Superiores de Ortodoncia, Mexico
    Implant Dent 20:273-9. 2011
    ..The purpose of this study was to assess the stability of sandblasted and acid-etched miniscrew implants based on orthodontic mechanics for space closure after tooth extraction...
  49. ncbi Quantitative assessment of orthodontic mini-implant displacement: the effect of initial force application
    Alexandra Ioana Holst
    University Clinic Erlangen, Dental Clinic 3 Department of Orthodontics, Erlangen, Germany
    Quintessence Int 41:59-66. 2010
    ..The purpose of this study was to assess the behavior of orthodontic mini-implants upon initial load application...
  50. ncbi Comparison of the loading behavior of self-drilling and predrilled miniscrews throughout orthodontic loading
    Yu Chih Wang
    Department of Orthodontics and Craniofacial Dentistry, Chang Gung Memorial Hospital, Taipei, Taiwan
    Am J Orthod Dentofacial Orthop 133:38-43. 2008
    ..The purpose of this retrospective cephalometric study was to compare the loading behavior of predrilled and self-drilling miniscrews placed in the infrazygomatic crest of the maxilla...
  51. ncbi Root contact during insertion of miniscrews for orthodontic anchorage increases the failure rate: an animal study
    Yuan Hou Chen
    Department of Orthodontics, School of Dentistry, National Taiwan University, Taipei, Taiwan
    Clin Oral Implants Res 19:99-106. 2008
    ..However, potential problems of damaging adjacent roots and their consequences during mini-implant placement in the alveolar process have not been clearly described...
  52. ncbi Miniaturization of biological assays -- overview on microwell devices for single-cell analyses
    Sara Lindstrom
    Division of Nanobiotechnology, School of Biotechnology, AlbaNova University Center, Royal Institute of Technology, Stockholm, Sweden
    Biochim Biophys Acta 1810:308-16. 2011
    ..However, cellular heterogeneity implies the importance of studying how individual cells respond, one by one, in order to learn more about drug targeting and cellular behavior...
  53. ncbi Stability of immediately loaded 3- and 6-mm miniscrew implants in beagle dogs--a pilot study
    Micah G Mortensen
    Department of Orthodontics, Baylor College of Dentistry, Texas A and M University System Health Science Center, Dallas, Tex, USA
    Am J Orthod Dentofacial Orthop 136:251-9. 2009
    ..We compared the stability of 3- and 6-mm long miniscrew implants (MSIs) loaded with orthopedic force levels...
  54. ncbi Evaluation of the stability of self-drilling mini-implants for maxillary anchorage under immediate loading
    Abraham B Lifshitz
    Department of Orthodontics, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida 33328, USA
    World J Orthod 11:352-6. 2010
    ..To evaluate the stability of self-drilling mini-implants used for immediate en masse retraction of all anterior teeth...
  55. ncbi Miniaturization technologies for molecular diagnostics
    R C McGlennen
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Clin Chem 47:393-402. 2001
    Molecular diagnostics devices are becoming smaller. With the advancement of miniaturization technologies, microchip-based systems will soon be available for genetic testing...
  56. ncbi Miniaturization of fluorescence microscopes using fibre optics
    Fritjof Helmchen
    Abteilung Zellphysiologie, Max Planck Insitut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany
    Exp Physiol 87:737-45. 2002
    ..Here, we review technological approaches to build miniaturized fluorescence microscopes and discuss their potential applications...
  57. ncbi Towards the miniaturization of GPCR-based live-cell screening assays
    Sofia A M Martins
    IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Department of Bioengineering, Instituto Superior Tecnico, Technical University of Lisbon, 1049 001 Lisbon, Portugal
    Trends Biotechnol 30:566-74. 2012
    ..screening platforms are well established, microarray and microfluidic technologies hold potential for miniaturization, automation, and biosensor integration that may well redefine the format of GPCR screening assays...
  58. ncbi Miniaturization (0.2 g) and evaluation of attachment techniques of telemetry transmitters
    B Naef-Daenzer
    Swiss Ornithological Institute, CH 6204 Sempach, Switzerland
    J Exp Biol 208:4063-8. 2005
    ..The new design is also suitable for miniature implants and signal modulation with sensors...
  59. ncbi Miniaturization and globalization of clinical laboratory activities
    Murilo R Melo
    Department of Physiology, Santa Casa de Sao Paulo Medical School, Sao Paulo, Brazil
    Clin Chem Lab Med 49:581-6. 2011
    ..Within the clinical laboratory industry the impetus for change has come from technological development (miniaturization, nanotechnology, and their collective effect on point-of-care testing; POCT) and the increasingly global ..
  60. ncbi Miniaturization of cell-based beta-lactamase-dependent FRET assays to ultra-high throughput formats to identify agonists of human liver X receptors
    Jayne Chin
    Department of Atherosclerosis and Endocrinology, Merck Research Laboratories, Rahway, NJ 07065, USA
    Assay Drug Dev Technol 1:777-87. 2003
    ..Clonal LXRbeta-GAL4-beta-lactamase cells were miniaturized into an ultra high throughput (3456-well nanoplates) screening format...
  61. ncbi Low-severity metacarpal and phalangeal fractures treated with miniature plates and screws
    Carlo Trevisan
    Clinica Ortopedica Università degli Studi Milano Bicocca, Azienda Ospedale S Gerardo, Via Donizetti, 106 20052 Monza, Italy
    Arch Orthop Trauma Surg 124:675-80. 2004
    ..The aim of our study was to evaluate the functional results after low-severity metacarpal and phalangeal fractures treated by miniature plates and screws...
  62. ncbi A high density microelectrode array biosensor for detection of E. coli O157:H7
    Stephen M Radke
    Biosystems and Agricultural Engineering, Michigan State University, 204 Farrall Hall, East Lansing, MI 48823, USA
    Biosens Bioelectron 20:1662-7. 2005
    ..coli O157:H7 detection in pure culture and inoculated food samples. The biosensor was able to discriminate between cellular concentrations of 10(4)-10(7)CFU/mL and has applications in detecting pathogens in food samples...
  63. ncbi User-friendly, miniature biosensor flow cell for fragile high fundamental frequency quartz crystal resonators
    Brigitte P Sagmeister
    Institute of Experimental Physics, Soft Matter Physics Division, Johannes Kepler University, Altenbergerstrasse 69, 4040 Linz, Austria
    Biosens Bioelectron 24:2643-8. 2009
    ....
  64. ncbi Development of a multiplexed microbioreactor system for high-throughput bioprocessing
    Nicolas Szita
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, 66 566 Cambridge, MA 02139, USA
    Lab Chip 5:819-26. 2005
    ..Finally, the multiplexed system is used to compare two different reactor designs, demonstrating that the reproducibility of the system permits the quantification of microbioreactor performance...
  65. ncbi Recent advances in microcontact printing
    Arjan P Quist
    Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Anal Bioanal Chem 381:591-600. 2005
    ..In this review, we describe the evolution of microcontact printing over the past five years. The review is categorized into three main sections: the improvements made to the technique, new variations, and new applications...
  66. ncbi Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II)
    Thomas Schröter
    Department of Molecular Therapeutics and Drug Discovery, Scripps Florida, Jupiter, Florida 33458, USA
    J Biomol Screen 13:17-28. 2008
    ..It can be concluded that both assay formats are suitable for the discovery of ROCK-II inhibitors, and the choice of assay format depends on reagents and/or screening technology available...
  67. pmc Miniature near-infrared dual-axes confocal microscope utilizing a two-dimensional microelectromechanical systems scanner
    Jonathan T C Liu
    Edward L Ginzton Laboratory, Stanford University, Stanford, California 94305, USA
    Opt Lett 32:256-8. 2007
    ..Reflectance and fluorescence images are obtained with a laser source at 785 nm, demonstrating the ability to perform real-time optical biopsy...
  68. ncbi SU-8 as a structural material for labs-on-chips and microelectromechanical systems
    Patrick Abgrall
    Singapore MIT Alliance, Nanyang Technological University, Singapore
    Electrophoresis 28:4539-51. 2007
    ..First, this article aims to review the different techniques and provides guidelines to the use of SU-8 as a structural material. Second, practical examples from our respective labs are presented...
  69. ncbi Simple absorbance-based assays for ultra-high throughput screening
    P Lavery
    Molecular Interactions and New Assay Technologies, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Essex, UK
    J Biomol Screen 6:3-9. 2001
    ..We also demonstrate the utility of kinetics measurements in miniaturized format with improvements in assay quality and the ability to extract detailed mechanistic information about inhibitors...
  70. ncbi Miniaturization of asymmetrical flow field-flow fractionation and application to studies on lipoprotein aggregation and fusion
    Gebrenegus Yohannes
    Laboratory of Analytical Chemistry, Department of Chemistry, University of Helsinki, FIN 00014 Helsinki, Finland
    Anal Biochem 354:255-65. 2006
    ..2 to 7.4, but treatment of LDL with alpha-chymotrypsin, sphingomyelinase, or copper sulfate leads to the formation of aggregated and fused LDL particles...
  71. ncbi A personal ultrasound imager (ultrasound stethoscope). A revolution in the physical cardiac diagnosis!
    J R T C Roelandt
    Department of Cardiology, Thoraxcentre, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Eur Heart J 23:523-7. 2002
  72. ncbi A miniature head-mounted two-photon microscope. high-resolution brain imaging in freely moving animals
    F Helmchen
    Biological Computation Research Department, Bell Laboratories, Lucent Technologies, Murray Hill, NJ 07974, USA
    Neuron 31:903-12. 2001
    ..Capillary blood flow and dendritic calcium transients were measured with high time resolution using line scans. In awake, freely moving rats, stable imaging was possible except during sudden head movements...
  73. ncbi Miniaturization of absorbance assays using the fluorescent properties of white microplates
    Paul Zuck
    Department of Automated Biotechnology, Merck and Company, 502 Louise Lane, North Wales, PA 19454, USA
    Anal Biochem 342:254-9. 2005
    b>Miniaturization of high-throughput screening (HTS) assays has several obvious advantages, including increased throughput and lower cost by reduction in reagent consumption...
  74. ncbi From micro- to nanofabrication with soft materials
    S R Quake
    Department of Applied Physics, MS 128 95, California Institute of Technology, Pasadena, CA 91125, USA
    Science 290:1536-40. 2000
    ....
  75. ncbi Ligand assays: from electrophoresis to miniaturized microarrays
    R P Ekins
    Division of Molecular Endocrinology, University College London Medical School, United Kingdom
    Clin Chem 44:2015-30. 1998
    ..The latter--applicable both to immunoassay and to DNA/RNA analysis--are likely to revolutionize the diagnostic and pharmaceutical fields in the next decade...
  76. ncbi Design and demonstration of a miniature catheter for a confocal microendoscope
    Andrew R Rouse
    Optical Science Center and the Department of Radiology, University of Arizona, Tucson, Arizona 85724, USA
    Appl Opt 43:5763-71. 2004
    ..The design and performance of the miniature objective and focus assembly are discussed. Primary applications of the system include diagnosis of disease in the gastrointestinal tract and female reproductive system...
  77. ncbi Miniaturization of intracellular calcium functional assays to 1536-well plate format using a fluorometric imaging plate reader
    Peter Hodder
    Department of Automated Biotechnology, Merck Research Laboratories, North Wales, PA 19454, USA
    J Biomol Screen 9:417-26. 2004
    ..The focus of the research described in this article is the miniaturization of an intracellular calcium assay to 1536-well plate format...
  78. pmc Fast-scanning two-photon fluorescence imaging based on a microelectromechanical systems two- dimensional scanning mirror
    Wibool Piyawattanametha
    James H Clark Center for Biomedical Engineering and Sciences, Stanford University, Stanford, California 94305, USA
    Opt Lett 31:2018-20. 2006
    ..Using such scanners we demonstrated two-photon microscopy and microendoscopy with fast-axis acquisition rates up to 3.52 kHz...
  79. ncbi Minibioreactors
    Sathish Kumar
    Biochemical Engineering Institute, Saarland University, 66123 Saarbruecken, Germany
    Biotechnol Lett 26:1-10. 2004
    ..g. membrane inlet mass spectrometry and NMR...
  80. ncbi Adaptive liquid microlenses activated by stimuli-responsive hydrogels
    Liang Dong
    Department of Electrical and Computer Engineering, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Nature 442:551-4. 2006
    ..But in recent years, advances in miniaturization technology have led to optical systems that no longer require complicated mechanical systems to tune and ..
  81. ncbi Progress in miniaturization of protein arrays--a step closer to high-density nanoarrays
    Christer Wingren
    Department of Immunotechnology, Lund University, BMC D13, SE 221 84 Lund, Sweden
    Drug Discov Today 12:813-9. 2007
    ..This review describes the progress and key issues in designing miniaturized protein arrays...
  82. ncbi The Moore's Law of microbiology - towards bacterial culture miniaturization with the micro-Petri chip
    Orit Gefen
    Racah Institute of Physics and the Center for Nanoscience and Nanotechnology, Hebrew University, Givat Ram, Jerusalem 91904, Israel
    Trends Biotechnol 26:345-7. 2008
    ....
  83. ncbi Handheld subcellular-resolution single-fiber confocal microscope using high-reflectivity two-axis vertical combdrive silicon microscanner
    Karthik Kumar
    Department of Electrical and Computer Engineering, University of Texas at Austin, Austin, TX, 78712, USA
    Biomed Microdevices 10:653-60. 2008
    ..With improvements to objective numerical aperture, our probe can enable precise evaluation of nuclear size, density, nucleus-to-cytoplasm ratio and cell density, which are important visual identifiers of epithelial precancers...
  84. ncbi Miniaturization of molecular biological techniques for gene assay
    Kang Yi Lien
    Institute of Nanotechnology and Microsystems Engineering, National Cheng Kung University, Tainan, 701, Taiwan
    Analyst 135:1499-518. 2010
    ..Some critical issues with the use of microfluidic-based systems for diagnosis of genetic diseases are also highlighted...
  85. ncbi Towards miniaturization of a structural genomics pipeline using micro-expression and microcoil NMR
    Wolfgang Peti
    The Scripps Research Institute, Department of Molecular Biology and the Joint Center of Structural Genomics, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Struct Funct Genomics 6:259-67. 2005
    ..Here, we outline ways towards miniaturization of a structural genomics pipeline with NMR screening for folded globular proteins, using a high-density micro-..
  86. ncbi Liquid phase interfacing and miniaturization in matrix-assisted laser desorption/ionization mass spectrometry
    Frantisek Foret
    Institute of Analytical Chemistry, Czech Academy of Sciences, Brno, Czech Republic
    Proteomics 2:360-72. 2002
    ..This short review summarizes the state-of-the-art in the interface miniaturization and strategies for analysis of limited sample amounts by matrix assisted laser desorption/ionization mass ..
  87. ncbi Silicon microsystems for neuroscience and neural prostheses
    Kensall D Wise
    Department of Electrical Engineering and Computer Science, The University of Michigan, Ann Arbor, MI 48109 2122, USA
    IEEE Eng Med Biol Mag 24:22-9. 2005
  88. ncbi First experiences with a new miniaturised life support system for mobile percutaneous cardiopulmonary bypass
    Matthias Arlt
    Department of Anaesthesiology, University Hospital Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Resuscitation 77:345-50. 2008
    ....
  89. pmc Hand-held echocardiography: added value in clinical cardiological assessment
    Giovanna Giannotti
    Division of Cardiology, University of Siena, Italy
    Cardiovasc Ultrasound 3:7. 2005
    ..The aim of the study was to verify if the routine use of a basic model of echocardiographic Hand Held Device (HHD) could be an important diagnostic tool during outpatient cardiologic consulting or in non-cardiologic hospital sections...
  90. ncbi Miniaturization and validation of a high-throughput serine kinase assay using the AlphaScreen platform
    Achim Von Leoprechting
    Perkin Elmer LAS Germany GmbH, Rodgau Jügesheim, Germany
    J Biomol Screen 9:719-25. 2004
    ..In this study, the authors describe the feasibility of miniaturization of a serine kinase assay using generic reagents in the AlphaScreen format...
  91. pmc Economy, speed and size matter: evolutionary forces driving nuclear genome miniaturization and expansion
    Thomas Cavalier-Smith
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Ann Bot 95:147-75. 2005
    ....
  92. ncbi On-chip culture system for observation of isolated individual cells
    I Inoue
    Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, 16-723A Komaba 3-8-1, Meguro, Tokyo, 153-8902, Japan
    Lab Chip 1:50-5. 2001
    ....
  93. ncbi Hand-carried cardiac ultrasound (HCU) device: recommendations regarding new technology. A report from the Echocardiography Task Force on New Technology of the Nomenclature and Standards Committee of the American Society of Echocardiography
    James B Seward
    American Society of Echocardiography, 1500 Sunday Drive, Suite 102, Raleigh, NC 27607, USA
    J Am Soc Echocardiogr 15:369-73. 2002
    ..However, appropriate user-specific training (Level 1 at a minimum) and assumption of responsibility are essential to ensure the most accurate acquisition, interpretation, and use of the data...
  94. ncbi Noncontact infrared-mediated thermocycling for effective polymerase chain reaction amplification of DNA in nanoliter volumes
    A F Huhmer
    Department of Chemistry, University of Virginia, Charlottesville 22901, USA
    Anal Chem 72:5507-12. 2000
    ..This sets the stage for microchip integration of the PCR process in the nanoliter volumes routinely manipulated in electrophoretic microchips...
  95. ncbi Exploiting the benefits of miniaturization for the enhancement of DNA microarrays
    Johan Vanderhoeven
    Vrije Universiteit Brussel, Department of Chemical Engineering, Brussels, Belgium
    Electrophoresis 25:3677-86. 2004
    ..this task, as it allows to induce strongly enhanced lateral transport rates, independently of the degree of miniaturization of the hybridization chamber...
  96. ncbi Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species
    Y Cui
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Science 293:1289-92. 2001
    ..The small size and capability of these semiconductor nanowires for sensitive, label-free, real-time detection of a wide range of chemical and biological species could be exploited in array-based screening and in vivo diagnostics...
  97. ncbi Flat-chip microanalytical enzyme sensor for salivary amylase activity
    Masaki Yamaguchi
    Department of Material Systems Engineering and Life Science, Faculty of Engineering, Toyama University, 3190 Gofuku, Toyama 930 8555, Japan
    Biomed Microdevices 7:295-300. 2005
    ..97 was fabricated with a sample volume of 50 microl. This research indicates the possibility of a wearable biosensor for continuous monitoring of salivary amylase activity...
  98. ncbi Planar microcoil-based microfluidic NMR probes
    C Massin
    Institute of Microelectronics and Microsystems, EPFL Swiss Federal Institute of Technology Lausanne, BM 3 108, Lausanne CH 1015, Switzerland
    J Magn Reson 164:242-55. 2003
    ..Finally, based on the presented model and measured data, future performance of planar microcoil-based microfluidic NMR probes is extrapolated and discussed...
  99. ncbi A novel piezoelectric quartz micro-array immunosensor for detection of immunoglobulinE
    Chunyan Yao
    Department of Clinical Laboratory, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    J Nanosci Nanotechnol 6:3828-34. 2006
    ..The correlation coefficient is 0.94 between ELISA and PZ immunosensor. After regeneration with NaOH the coated immunosensor can be reused 6 times without appreciable loss of activity...
  100. ncbi Nucleic acid purification using microfabricated silicon structures
    Nathaniel C Cady
    Department of Microbiology, Cornell University, 317 Stocking Hall, Ithaca, NY 14853, USA
    Biosens Bioelectron 19:59-66. 2003
    ....
  101. ncbi Patterning of photosensitive polyimide LB film and its application in the fabrication of biomolecular microphotodiode array
    Se Young Oh
    Department of Chemical Engineering, Sogang University, 1 Shinsoo Dong, Mapo gu, Seoul 121 742, Republic of Korea
    Biosens Bioelectron 19:103-8. 2003
    ..Especially, current-voltage characteristics of the protein multilayers were investigated by scanning tunneling microscopy (STM) and its application in biomolecular photodiode was also examined...

Research Grants81

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  2. Needle-Implantable, Wireless Multi-Sensor for Continuous Glucose Monitoring
    Santhisagar Vaddiraju; Fiscal Year: 2010
    ..The underlying principle in developing this miniaturized sensor hinges on extreme miniaturization utilizing light, both as a powering source and a communication link...
  3. Fast accurate ultrasensitive in vitro assay to determine BoNT potency &stability
    ARMIN H REITMAIR; Fiscal Year: 2012
    ..with 2c-ALEX spectroscopy for quantification of enzymatic activity, a new breakthrough approach for assay miniaturization and increased throughput termed "single molecule optofluidics"...
  4. Multiplex ALEX-based Test for Protease Activity Profiling in Arthritic Joints
    ARMIN H REITMAIR; Fiscal Year: 2013
    ..of microfluidics-based sample handling with ALEX spectroscopy, a new breakthrough approach for assay miniaturization termed "single molecule optofluidics", and ii) enhanced throughput using a multifoci excitation/detection ..
  5. Parallel en-face optical coherence microscopy with adaptive focus
    Guoqiang Li; Fiscal Year: 2012
    ..b>Miniaturization and portability of the system will be considered in the future...
  6. Parallel en-face optical coherence microscopy with adaptive focus
    Guoqiang Li; Fiscal Year: 2011
    ..b>Miniaturization and portability of the system will be considered in the future...
  7. RAPID NEURAL DIFFERENTIATION OF HUMAN STEM CELLS: A NOVEL DRUG DISCOVERY PLATFORM
    MARIA INES MORANO; Fiscal Year: 2010
    ..In addition to increasing the efficiency of high-throughput screening (HTS) by assay miniaturization and multiplexing, various initiatives have been taken to improve the science of predicting toxicity and ..
  8. High-throughput assay development for molecular probes targeting the ULK1 kinase
    DEREK RONALD DUCKETT; Fiscal Year: 2013
    ..This assay uses a bead-based proximity format ideally suited for miniaturization and high-throughput screening (HTS)...
  9. Multiplexed Protein &miRNA Biomarker-based Next-gen Test for Alzheimers Disease
    ARMIN H REITMAIR; Fiscal Year: 2013
    ..of microfluidics- based sample handling with ALEX spectroscopy, a new breakthrough approach for assay miniaturization termed "single molecule opt fluidics", and ii) enhanced throughput using a multifocal excitation/detection ..
  10. Vesicular retrieval and reuse at CNS nerve terminals
    Richard W Tsien; Fiscal Year: 2012
    ..nervous system (CNS) relies critically on an abundance of synapses and has thus benefitted from their extreme miniaturization. However, the ~1 micrometer size of typical CNS synapses poses great challenges for their cell biology and ..
  11. Development of a Pediatric Ventricular Assist Device
    Robert Jarvik; Fiscal Year: 2009
    ..We will rapidly implement dramatic miniaturization of the Jarik 2000 hear and apply it to pediatric patients...
  12. Evaluation, Validation, and Implementation of Acoustic Droplet Ejector Technology
    Martin E Adelson; Fiscal Year: 2010
    ..human health, numerous internal benefits would be achievable such as significant cost savings due to a miniaturization process and improved environmental policies from decreased plastic consumption...
  13. The role of prostaglandin d2 in hair follicle biology
    LUIS ANDRES GARZA; Fiscal Year: 2012
    ..K14-COX2 transgenic) and man (androgenetic alopecia) of elevations in PGDa levels and the phenotype of hair miniaturization and sebaceous hyperplasia. Our hypothesis is that PGD2 mediates these effects...
  14. Technology for detection and quantitation of telomeric DNA aberrations in cancer
    Harold C Riethman; Fiscal Year: 2012
    ..In addition, it is amenable to future refinement to permit miniaturization and multiplexing of the assays...
  15. Acoustic Behavior - Neural and Comparative Bases
    Ronald R Hoy; Fiscal Year: 2013
    ..A goal of this work is to reveal the basic principles behind auditory function at all size scales. Miniaturization is coveted goal in practical engineering...
  16. ALEX for fast ultrasensitive multiplexed detection &quantification of microRNAs
    ARMIN H REITMAIR; Fiscal Year: 2013
    ..of microfluidics-based sample handling with ALEX spectroscopy, a new breakthrough approach for assay miniaturization termed "single molecule optofluidics", and ii) enhanced throughput using a multifoci excitation/detection ..
  17. Multiplex platform for point of care newborn screening of hyperbilirubinemia
    NICHOLAS TROTTA; Fiscal Year: 2013
    ..The digital microfluidic technology enables miniaturization of assays and significantly reduces reagent and sample volumes, lowering not only the costs but also the ..
  18. Targeted Multi-Spectral Dual Axes Confocal Imaging of In Vivo Molecular Expressio
    Thomas D Wang; Fiscal Year: 2013
    ..Post-objective scanning provides a large field-of-view as well as scalability and miniaturization of the optics, and a replicated parabolic mirror directs collimated, multi-spectral beams to a common focus...
  19. Biosensing in electrochemically controlled nano-junctions
    Krzysztof Slowinski; Fiscal Year: 2013
    ..The future development of the biochip methods depends on further miniaturization. It is clear, furthermore, that the processing of readout from biochips based on light intensity is ..
  20. Micro-Liver Platform Development for Evaluating Drug Disposition and Toxicity In
    SALMAN KHETANI; Fiscal Year: 2010
    ..II project is to further develop and optimize these microscale human liver cultures and couple them with miniaturization strategies and assay technologies for cost-effective high-throughput in vitro screening...
  21. Point of Care Ultrasound for Maternal Health
    LOWELL SCOTT SMITH; Fiscal Year: 2010
    ..Driven by advances in electronic miniaturization and computing power, medical ultrasound is trending toward smaller, portable, lower cost systems with real-..
  22. Force spectroscopy platform for label free genome sequencing
    DMITRI VEZENOV; Fiscal Year: 2010
    ..The development of force spectroscopy in the highly parallel format allows for further miniaturization of the sequencing device and automation of the procedures by employing microfluidics for steps involving SNA ..
  23. Rapid point of care HIV PCR diagnostic device
    JOHN CHARLES GERDES; Fiscal Year: 2010
    ..We propose the miniaturization and automation of nucleic acid testing methods to enable low cost, near patient testing.
  24. A New Integrated Endoscope System
    Lih Y Lin; Fiscal Year: 2012
    ..and 3-dismentional imaging capability;(2) maintaining high resolution over various imaging depths;(3) probe miniaturization;(4) the weak intrinsic contrast between normal tissue and pre- or early cancers;and (5) the lack of molecular ..
  25. SmartStop: Programmable Transdermal Nicotine Replacement Therapy
    Kuowei Chang; Fiscal Year: 2013
    ..Technical innovations include (i) automated "on-off" for nicotine administration, (ii) miniaturization combined with full functionality and visual appeal, and (iii) key safety features including insulation of the ..
  26. JCIMPT-Complexes
    Raymond C Stevens; Fiscal Year: 2013
    ..b>Miniaturization and automation are the major themes in the systematic development of new technologies to study membrane ..
  27. Automated crystallization of biological macromolecules
    Andrzej Weichsel; Fiscal Year: 2010
    ..Recent developments in automation and miniaturization technology have helped to overcome these limitations and have proven to be very successful in obtaining ..
  28. Mitigating risk in a closed loop system by exercise detection and miniaturization
    Peter G Jacobs; Fiscal Year: 2013
    ..This miniaturized system will be tested in inpatient and outpatient closed loop studies. ..
  29. Compact, cost-effective, and operator-friendly fundus camera for early detection
    DAVID MAXWELL KLEINMAN; Fiscal Year: 2010
    ..project is a small bench top prototype platform with a hand- held unit that will serve as a launching pad for miniaturization efforts scheduled in Phase II...
  30. Compact microfluidic PET probe concentrator for preclinical and in vitro imaging
    ROBERT MICHAEL VAN DAM; Fiscal Year: 2013
    ..Such a system would enable on-demand production of diverse probes at affordable cost. Current miniaturization efforts have focused primarily on the synthesis itself, and not on downstream processes such as purification ..
  31. Multiplexed Onchip Nanomagnetic Immunoassay for TOxin Reporting (MONITOR)
    John Collins; Fiscal Year: 2012
    ..This miniaturization will enable simple, multiplexed, high sensitivity, high specificit, integrated automated rapid total analysis ..
  32. Nanoporous Membranes for cellular microarrays and in vitro assays
    Thomas R Gaborski; Fiscal Year: 2011
    ..Missing from this miniaturization, however, are cell culture microarrays...
  33. Miniaturized Laser Sources for Optical Neuroprostheses
    MATTHEW DUMMER; Fiscal Year: 2012
    ..However, the practical implementation of INS requires substantial miniaturization, with the key missing piece being an optical source that can be incorporated into an implantable device...
  34. Development of Near Real-Time, Multiplexed Diagnostics for Viral Hemorrhagic Feve
    John H Connor; Fiscal Year: 2013
    ..Photonics systems have the advantage of being rapid, label-free systems with an established record of miniaturization and inexpensive manufacture...
  35. Self-Applied Wearable Ultrasound Therapy for Osteoarthritis Management in Rural C
    GEORGE KENNETH LEWIS; Fiscal Year: 2013
    ..The system relies on aggressive miniaturization and integration of the ultrasound transducer, electronics, and power supply to produce an iPod- sized low-..
  36. Line-scanned MEMS-based dual-axis confocal microscopy to detect oral lesions in v
    JONATHAN TENG CHIEH LIU; Fiscal Year: 2013
    ..However, miniaturization is a challenge and previous in vivo systems have necesitated trade-offs between critical parameters such as ..
  37. Blur, Accommodation, and Vision
    Martin S Banks; Fiscal Year: 2013
    ..One set of experiments will use miniaturization effects developed in photography...
  38. New Materials for High Efficiency Protein Separations
    Mary J Wirth; Fiscal Year: 2011
    ..The combined miniaturization and higher field promises a combined 100-fold increase in speed along each dimension of the separation to ..
  39. Subdermal EEG Recorder: A Lifelong Monitor for Epilepsy and Other Brain Disorders
    KEITH BRAFFORD; Fiscal Year: 2012
    ..completion of Phase I will lead to a Phase II study of surgery methods, mechanical reliability and electronic miniaturization with a Phase II goal of an animal-model demonstration of a pre-clinical prototype...
  40. Non-invasive Hemodynamic Monitoring of Physiological Parameter
    Aaron M Dentinger; Fiscal Year: 2010
    Driven by advances in electronic miniaturization, probe construction techniques and computing power, medical ultrasound is experiencing a trend toward smaller, lower cost systems with real-time volumetric imaging capabilities...
  41. Ultra-Compact MRI: A new cost-effective tool optimized for developmental biology
    Andrew F McDowell; Fiscal Year: 2011
    ..rugged, and of modest cost, the accomplishment of these aims will show that this new, technically innovative miniaturization of MRI technology is fully capable of research-quality imaging in the hands of typical researchers...
  42. Dynamic Imaging of EMT in the Breast Cancer Microenvironment
    Frank B Gertler; Fiscal Year: 2013
    ..capable of detecting multiple markers of disease progression, and its novel architecture has enabled radical miniaturization conducive to implantation in rodent models for continuous study of the microenvironment...
  43. HTS assay development for bacterial transcription factors
    Richard E Wolf; Fiscal Year: 2013
    ..This will establish the applicability of the screens to HTS, and will determine their suitability for miniaturization. We will validate and characterize putative CR and SoxS inhibitors using a battery of well-established in ..
  44. High Throughput Screening for compounds reducing cell surface prion protein
    Corinne Ida Lasmezas; Fiscal Year: 2013
    ..Assay miniaturization and screening will be performed at the MLPCN laboratory of Scripps Florida led by Peter Hodder...
  45. Thalamic infusions as a treatment of limbic epilepsy
    EDWARD HILTNER BERTRAM; Fiscal Year: 2010
    ..This development has been made possible in part by the progressive miniaturization of electronics...
  46. Instacortisol: A realtime and continuous assessment of cortisol in ISF
    MANJU GROVER VENUGOPAL; Fiscal Year: 2012
    ..cortisol sensor clotting mitigation, cortisol sensor electronic Interface board development, cortisol sensor miniaturization efforts, clinical validation and the design integration feasibility...
  47. Distance Bounded Impulse Radio For Continuous Glucose Sensor
    GREGORY JOHN SEIFERT; Fiscal Year: 2013
    ..and microprocessors, due to improved silicon technologies, has dramatically increased the capabilities and miniaturization of sensors for health monitoring...
  48. Noninvasive Blood Flow Mapping for Surgical Guidance of Vascular Birthmarks
    Bernard Choi; Fiscal Year: 2010
    ..Due to the potentially low cost and feasible miniaturization of the imaging technology, a quantitative demonstration of improved treatment efficacy with real-time blood-..
  49. Towards a Miniaturized Human Liver Array for High-throughput Screening
    SALMAN KHETANI; Fiscal Year: 2010
    ..Here, we propose to further develop and optimize these microscale human liver cultures and couple them with miniaturization strategies and assay technologies for cost-effective high-throughput screening (HTS) applications...
  50. Ultraminiaturized microfluidics-based drug toxicity screening platform using iPSC
    Zhizhong Yin; Fiscal Year: 2013
    ..assays in general, successful application of these cells for high-throughput drug screening requires miniaturization. Miniaturization reduces the number of cells required thereby increasing throughput per batch of ..
  51. MULTI IMAGER COMPATIBLE ROBOT FOR PROSTATE ACCESS
    Dan Stoianovici; Fiscal Year: 2001
    ..Innovative engineering research will address design miniaturization, adequate material selection and manufacturing...
  52. MULTI IMAGER COMPATIBLE ROBOT FOR PROSTATE ACCESS
    Dan Stoianovici; Fiscal Year: 2004
    ..Innovative engineering research will address design miniaturization, adequate material selection and manufacturing...
  53. Hexalog: A Rapid-Acting Ultra-Concentrated Insulin Formulation
    BRUCE HILL FRANK; Fiscal Year: 2013
    ..U-500 formulation would extend by fivefold the reservoir life of current disposable pumps and/or would enable miniaturization of these disposable pumps without decreasing reservoir life...
  54. Integrated Optical Particle Trap for Biomolecule Analysis and Manipulation
    Holger Schmidt; Fiscal Year: 2010
    b>Miniaturization is a growing trend for bioanalytical instruments...
  55. WIRELESS IN VIVO OPTICAL CONTROL OF STRESS NEURAL CIRCUITS AND GPCR SIGNALING
    Michael R Bruchas; Fiscal Year: 2013
    ..We propose to: 1) Develop and refine micro-ILED devices by further miniaturization and adding additional functions to the semiconductor platform 2) to dissect hypothalamic and central amygalar ..
  56. Multiplexed screening of protein expression libraries
    LAWRENCE KAUVAR; Fiscal Year: 2009
    ..The identified clones were too rare for recovery by conventional means lacking the extreme miniaturization of the Trellis approach (100,000 fold reduction)...
  57. Droplet based screening of molecular libraries in a microfluidic device
    Darren R Link; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Miniaturization of laboratory operations in biology and chemistry has reduced reaction volumes from a few milliliters (in ..
  58. Optogenetic Multiparametric Assay for HT Cardiotoxicity Testing
    Fabio Cerignoli; Fiscal Year: 2013
    ..myocytes for Calcium Transients, but are still limited by use of electrode devices for pacing that prevents miniaturization beyond 96- well format...
  59. Miniature, rapid, and 3-dimensional OCT scanner for dental imaging
    GUANGHAI JIN; Fiscal Year: 2009
    ..This will enable the miniaturization of the two dimensional probe, so that dentist need only hold a probe in a fixed position against a tooth and ..
  60. High Thruput EM Sample Preparation for Structural Biology
    Clinton S Potter; Fiscal Year: 2013
    ..We proposed to develop a novel approach to TEM specimen preparation, incorporating miniaturization and small volume (picoliter to nanoliter) dispensing that will enable TEM to be integrated seamlessly into ..
  61. Passive Flow Control for Integrated Genomic Analysis Microchips
    MATTHEW RICHARD BEGLEY; Fiscal Year: 2013
    ..in particular, microfluidic integrated genomic analysis chips), and represents a significant step towards miniaturization of instrumentation for point-of-care testing...
  62. Awareness Enhancement and Monitoring Device for Treatment of Trichotillomania
    Joseph Himle; Fiscal Year: 2007
    ..In Phase II, the technology will continue to be developed for miniaturization and manufacturability and we will extend this body of research with human studies conducted on individuals ..
  63. FUNCTION OF NOGGIN IN HAIR FOLLICLE GROWTH AND DISEASE
    Vladimir Botchkarev; Fiscal Year: 2006
    ..disorders (androgenic alopecia and alopecia areata) are characterized by the development of hair follicle miniaturization with significant elongation of the resting stage, shortening of the growth stage of hair cycle, and hair loss...
  64. A ROLE FOR NOGGIN AND BMP2/4 IN HAIR GROWTH CONTROL
    Vladimir Botchkarev; Fiscal Year: 2003
    ..most common hair growth disorder (androgenic alopecia and alopecia areata) are characterized by hair follicle miniaturization with significant elongation of the resting stage, shortening of the growth stage of the hair cycle, and hair ..
  65. Magnetic Nanoparticles for Advanced Hearing Devices
    Charles Seeney; Fiscal Year: 2002
    ..Clinical advancement of IHD technology could be achieved through miniaturization of the magnetic implants...
  66. POLYMER PARTICLES AS SEPARATION MEDIA FOR CHROMATOGRAPHY
    JEAN FRECHET; Fiscal Year: 2005
    ..trend of rapid decrease in size of samples available for separations, our research will push even further the miniaturization of polymer-based separation technology using microcolumns and packed capillaries...
  67. Novel Assay for Ethylene Glycol Toxicity
    HANS KLOEPFER; Fiscal Year: 2002
    ..To make such a level of miniaturization and simplicity feasible, we have developed a capillary fill sampling technique permitting specimen dosing, ..
  68. Microfluidics-Based Platform for Screening Combinatorial Drug Treatments
    Kaushal Rege; Fiscal Year: 2009
    ..to interrogate cells with combinatorial stimuli using microfluidics can lead to the parallelization and miniaturization of the secondary screening step...
  69. VAGAL GASTRIC MOTOR CONTROL IN MICE
    ELITA PARTOSEOEDARSO; Fiscal Year: 2002
    ..This proposal will enable us to surmount the difficulties associated with physiological miniaturization. Thus we will be able to exploit genetically engineered mice using state-of-the-art equipment for measuring ..
  70. Methyltransferase Drug Discovery
    Haiching Ma; Fiscal Year: 2009
    ..gold standard for HKMTs with large signal/background ratio;Aim 2 Reduce assay costs by ultra-miniaturization and streamline assay protocols for robust HTS;Aim 3 Conduct HTS and identify new compounds for an HKMT using ..
  71. Implantable PV ECG Telemetry System
    Huntly Millar; Fiscal Year: 2009
    ..The specific aims of this Phase II effort are: a) miniaturization of the application specific integrated circuit (ASIC), b...
  72. Development of a High Throughput Genotoxicity Assay
    NEAL HUEBOTTER; Fiscal Year: 2004
    ..Sensitive detection of mutagenically induced revertants allows for the miniaturization and incorporation of the assay into a 96- or 384-well format for rapid simultaneous genotoxicity screening of ..
  73. SUBCUTANEOUS GLUCOSE BIOSENSORS
    Adam Heller; Fiscal Year: 1999
    ..to provide sufficient specificity for glucose, for one-point in vivo calibration; the feasibility of further miniaturization, while the reliability, stability and operational life are improved; the feasibility of achieving >99% ..
  74. Micromachined Fluid Transfer Devices for Molecular Screening
    ROBERT HAUSHALTER; Fiscal Year: 2006
    ..High throughput experiments such as compound library reformatting, nanoliter fluid transfer, assay miniaturization and molecular library screening would all greatly benefit from a more accurate and faster fluid transfer ..
  75. Immunomagnetic Diffractometry for Rapid Biomolecular Detection
    Cagri Savran; Fiscal Year: 2009
    ..and required expertise for operation and renders these label-based platforms not necessarily suitable for miniaturization and high-throughput detection...
  76. ON-CHIP DNA PURIFICATION/PCR FOR CANCER DIAGNOSTICS
    James Landers; Fiscal Year: 2000
    ..In addition Co allowing for rapid separations as a result of miniaturization, the "chips" also provide a convenient platform for integrating pre-electrophoresis sample processing...
  77. Technological Development Towards a Cortical Prosthesis
    Patrick Rousche; Fiscal Year: 2005
    Forty years ago, exciting advances in neuroscience, biomaterials, electronics and miniaturization fueled development of the cochlear implant, the world's first and most successful auditory neuroprosthesis...
  78. NON-INVASIVE PNEUMOTHORAX DETECTOR
    ALAN GRESZLER; Fiscal Year: 2009
    ..The next steps in commercialization of this device are to complete the miniaturization and integration with the PDA, complete the clinical study, and apply to the FDA for 510(k) clearance to ..
  79. Thin Film Magnetic Sensors for Ultrathin Bronchoscope Navigation
    ERIK LANGE; Fiscal Year: 2006
    ..They are generally too large for use in ultrathin bronchoscopes and are unsuitable for further miniaturization. The proposed program uses solid-state thin-film giant magneto-resistive (GMR) magnetic field sensors to ..
  80. Micro-Robotics for Minimally-Invasive Neurosurgery
    JAMES GOLDIE; Fiscal Year: 2004
    ..Moreover, since there is a tradeoff between strength/stability and miniaturization, the project will show how the optimum design point in this tradeoff space depends on the particulars of the ..
  81. Micro-Robotics for Minimally-Invasive Neurosurgery
    JAMES GOLDIE; Fiscal Year: 2009
    ..will be developed and tested with phantoms to address a critical subset of these requirements: (1) sufficient miniaturization and degrees of freedom to allow conformance to five envisioned neurosurgical corridors, (2) safe levels of ..