Summary: The design or construction of objects greatly reduced in scale.
Publications252 found, 100 shown here
- Optical-transparent and flexible glucose sensor with ITO electrodeKohji Mitsubayashi
Department of Human and Information Science, School of Engineering, Tokai University, 1117 Kitakaname, Hiratsuka, Kanagawa 259 1292, Japan
Biosens Bioelectron 19:67-71. 2003..The sensor was possible to be used for measuring glucose from 0.06 to 1.24 mmol/l (correlation coefficient: 0.999), including the reported concentration of tear glucose in normal (0.14 mmol/l), with good reproducibility...
- Point-of-care testing and molecular diagnostics: miniaturization requiredFrederick L Kiechle
Department of Pathology, Pathology Consultants of South Broward, LLP, Memorial Regional Hospital, Hollywood, FL 33021, USA
Clin Lab Med 29:555-60. 2009..The creation of such a device requires miniaturization of current technologies and the use of microfluidics, microarrays, and small-diameter capillary tubes to ..
- Application of microbioreactors in fermentation process development: a reviewDaniel Schäpper
Department of Chemical and Biochemical Engineering, Technical University of Denmark, 2800, Lyngby, Denmark
Anal Bioanal Chem 395:679-95. 2009..Current microbioreactor technology is analyzed in this review paper, focusing on its industrial applicability, and directions for future research are presented...
- Microtiter plates as mini-bioreactors: miniaturization of fermentation methodsWouter A Duetz
Enzyscreen, Biopartner Center Leiden, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
Trends Microbiol 15:469-75. 2007..In this review, I will discuss these fundamental issues and describe the current applications of microtiter plates in microbiology. Microtiter plates can now be considered a mature alternative to Erlenmeyer shake flasks...
- Miniaturization of biological assays -- overview on microwell devices for single-cell analysesSara Lindstrom
Division of Nanobiotechnology, School of Biotechnology, AlbaNova University Center, Royal Institute of Technology, Stockholm, Sweden
Biochim Biophys Acta 1810:308-16. 2011..However, cellular heterogeneity implies the importance of studying how individual cells respond, one by one, in order to learn more about drug targeting and cellular behavior...
- Miniaturization and validation of a sensitive multiparametric cell-based assay for the concomitant detection of microtubule-destabilizing and microtubule-stabilizing agentsEmilie Vassal
Universite Joseph Fourier, INSERM U366 CS DRDC CEA Grenoble, France
J Biomol Screen 11:377-89. 2006..This assay was validated using known compounds. This new cell-based assay represents an alternative to both global cytotoxicity assays and in vitro tubulin assembly assays commonly used for the detection of microtubule poisons...
- A new stoichiometric miniaturization strategy for screening of industrial microbial strains: application to cellulase hyper-producing Trichoderma reesei strainsEtienne Jourdier
IFP Energies nouvelles, 1 et 4 Avenue de Bois Préau, 92852 Rueil Malmaison, France
Microb Cell Fact 11:70. 2012..To ensure an effective high-throughput screening, miniaturized laboratory conditions must mimic industrial conditions, especially for oxygen transfer, feeding capacity and pH stabilization...
- Effects of circuit miniaturization in reducing inflammatory response to infant cardiopulmonary bypass by elimination of allogeneic blood productsEdward Hickey
Division of Pediatric Cardiac Surgery, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
Ann Thorac Surg 81:S2367-72. 2006..This would suggest an advantage for eliminating blood use in infant cardiopulmonary bypass through circuit miniaturization. In this article, we review the data supporting this rationale and provide the results from studies in our ..
- Droplet-based microfluidic platforms for the encapsulation and screening of Mammalian cells and multicellular organismsJenifer Clausell-Tormos
Institut de Science et d Ingenierie Supramoleculaires, Universite Louis Pasteur, Strasbourg Cedex, France
Chem Biol 15:427-37. 2008..However, further miniaturization of conventional microtiter plate technology is problematic due to evaporation and capillary action...
- In vivo fiber-optic confocal reflectance microscope with an injection-molded plastic miniature objective lensKristen Carlson
Department of Biomedical Engineering, The University of Texas at Austin, 1 University Station, C0800 ENS10, Austin, Texas 78712, USA
Appl Opt 44:1792-7. 2005..Confocal images of ex vivo cervical tissue biopsies and in vivo human lip taken at 15 frames/s demonstrate the microscope's capability of imaging cell morphology and tissue architecture...
- Miniaturization of fluorescence microscopes using fibre opticsFritjof Helmchen
Abteilung Zellphysiologie, Max Planck Insitut für medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany
Exp Physiol 87:737-45. 2002..Here, we review technological approaches to build miniaturized fluorescence microscopes and discuss their potential applications...
- Miniaturization (0.2 g) and evaluation of attachment techniques of telemetry transmittersB Naef-Daenzer
Swiss Ornithological Institute, CH 6204 Sempach, Switzerland
J Exp Biol 208:4063-8. 2005..The new design is also suitable for miniature implants and signal modulation with sensors...
- Towards the miniaturization of GPCR-based live-cell screening assaysSofia A M Martins
IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Department of Bioengineering, Instituto Superior Tecnico, Technical University of Lisbon, 1049 001 Lisbon, Portugal
Trends Biotechnol 30:566-74. 2012..screening platforms are well established, microarray and microfluidic technologies hold potential for miniaturization, automation, and biosensor integration that may well redefine the format of GPCR screening assays...
- Miniaturization technologies for molecular diagnosticsR C McGlennen
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455, USA
Clin Chem 47:393-402. 2001Molecular diagnostics devices are becoming smaller. With the advancement of miniaturization technologies, microchip-based systems will soon be available for genetic testing...
- Organic photodiodes for biosensor miniaturizationJason R Wojciechowski
Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, DC 20375, USA
Anal Chem 81:3455-61. 2009..b>Miniaturization of biosensors is essential for use in the field or at the point of care...
- Miniaturization and globalization of clinical laboratory activitiesMurilo R Melo
Department of Physiology, Santa Casa de Sao Paulo Medical School, Sao Paulo, Brazil
Clin Chem Lab Med 49:581-6. 2011..Within the clinical laboratory industry the impetus for change has come from technological development (miniaturization, nanotechnology, and their collective effect on point-of-care testing; POCT) and the increasingly global ..
- Low-severity metacarpal and phalangeal fractures treated with miniature plates and screwsCarlo Trevisan
Clinica Ortopedica Università degli Studi Milano Bicocca, Azienda Ospedale S Gerardo, Via Donizetti, 106 20052 Monza, Italy
Arch Orthop Trauma Surg 124:675-80. 2004..The aim of our study was to evaluate the functional results after low-severity metacarpal and phalangeal fractures treated by miniature plates and screws...
- Miniaturization of cell-based beta-lactamase-dependent FRET assays to ultra-high throughput formats to identify agonists of human liver X receptorsJayne Chin
Department of Atherosclerosis and Endocrinology, Merck Research Laboratories, Rahway, NJ 07065, USA
Assay Drug Dev Technol 1:777-87. 2003..Clonal LXRbeta-GAL4-beta-lactamase cells were miniaturized into an ultra high throughput (3456-well nanoplates) screening format...
- Integrating whole transcriptome assays on a lab-on-a-chip for single cell gene profilingN Bontoux
Laboratoire de Neurobiologie et Diversité Cellulaire, CNRS UMR 7637, ESPCI, Paris Cedex 05, France
Lab Chip 8:443-50. 2008..This demonstrates the outstanding sensitivity of the microfluidic method...
- Miniaturization in functional genomics and proteomicsSascha Sauer
Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, Ihnestrasse 73, D 14195 Berlin, Germany
Nat Rev Genet 6:465-76. 2005..b>Miniaturization of biological assays is an important prerequisite to achieve these goals in the near future.
- Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II)Thomas Schröter
Department of Molecular Therapeutics and Drug Discovery, Scripps Florida, Jupiter, Florida 33458, USA
J Biomol Screen 13:17-28. 2008..It can be concluded that both assay formats are suitable for the discovery of ROCK-II inhibitors, and the choice of assay format depends on reagents and/or screening technology available...
- Simple absorbance-based assays for ultra-high throughput screeningP Lavery
Molecular Interactions and New Assay Technologies, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Essex, UK
J Biomol Screen 6:3-9. 2001..We also demonstrate the utility of kinetics measurements in miniaturized format with improvements in assay quality and the ability to extract detailed mechanistic information about inhibitors...
- SU-8 as a structural material for labs-on-chips and microelectromechanical systemsPatrick Abgrall
Singapore MIT Alliance, Nanyang Technological University, Singapore
Electrophoresis 28:4539-51. 2007..First, this article aims to review the different techniques and provides guidelines to the use of SU-8 as a structural material. Second, practical examples from our respective labs are presented...
- Recent advances in microcontact printingArjan P Quist
Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA
Anal Bioanal Chem 381:591-600. 2005..In this review, we describe the evolution of microcontact printing over the past five years. The review is categorized into three main sections: the improvements made to the technique, new variations, and new applications...
- Miniature near-infrared dual-axes confocal microscope utilizing a two-dimensional microelectromechanical systems scannerJonathan T C Liu
Edward L Ginzton Laboratory, Stanford University, Stanford, California 94305, USA
Opt Lett 32:256-8. 2007..Reflectance and fluorescence images are obtained with a laser source at 785 nm, demonstrating the ability to perform real-time optical biopsy...
- Miniaturization of intracellular calcium functional assays to 1536-well plate format using a fluorometric imaging plate readerPeter Hodder
Department of Automated Biotechnology, Merck Research Laboratories, North Wales, PA 19454, USA
J Biomol Screen 9:417-26. 2004..The focus of the research described in this article is the miniaturization of an intracellular calcium assay to 1536-well plate format...
- The Moore's Law of microbiology - towards bacterial culture miniaturization with the micro-Petri chipOrit Gefen
Racah Institute of Physics and the Center for Nanoscience and Nanotechnology, Hebrew University, Givat Ram, Jerusalem 91904, Israel
Trends Biotechnol 26:345-7. 2008....
- Handheld subcellular-resolution single-fiber confocal microscope using high-reflectivity two-axis vertical combdrive silicon microscannerKarthik Kumar
Department of Electrical and Computer Engineering, University of Texas at Austin, Austin, TX, 78712, USA
Biomed Microdevices 10:653-60. 2008..With improvements to objective numerical aperture, our probe can enable precise evaluation of nuclear size, density, nucleus-to-cytoplasm ratio and cell density, which are important visual identifiers of epithelial precancers...
- Adaptive liquid microlenses activated by stimuli-responsive hydrogelsLiang Dong
Department of Electrical and Computer Engineering, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Nature 442:551-4. 2006..But in recent years, advances in miniaturization technology have led to optical systems that no longer require complicated mechanical systems to tune and ..
- Design and demonstration of a miniature catheter for a confocal microendoscopeAndrew R Rouse
Optical Science Center and the Department of Radiology, University of Arizona, Tucson, Arizona 85724, USA
Appl Opt 43:5763-71. 2004..The design and performance of the miniature objective and focus assembly are discussed. Primary applications of the system include diagnosis of disease in the gastrointestinal tract and female reproductive system...
- Progress in miniaturization of protein arrays--a step closer to high-density nanoarraysChrister Wingren
Department of Immunotechnology, Lund University, BMC D13, SE 221 84 Lund, Sweden
Drug Discov Today 12:813-9. 2007..This review describes the progress and key issues in designing miniaturized protein arrays...
- MinibioreactorsSathish Kumar
Biochemical Engineering Institute, Saarland University, 66123 Saarbruecken, Germany
Biotechnol Lett 26:1-10. 2004..g. membrane inlet mass spectrometry and NMR...
- Miniaturization of absorbance assays using the fluorescent properties of white microplatesPaul Zuck
Department of Automated Biotechnology, Merck and Company, 502 Louise Lane, North Wales, PA 19454, USA
Anal Biochem 342:254-9. 2005b>Miniaturization of high-throughput screening (HTS) assays has several obvious advantages, including increased throughput and lower cost by reduction in reagent consumption...
- Miniaturization of molecular biological techniques for gene assayKang Yi Lien
Institute of Nanotechnology and Microsystems Engineering, National Cheng Kung University, Tainan, 701, Taiwan
Analyst 135:1499-518. 2010..Some critical issues with the use of microfluidic-based systems for diagnosis of genetic diseases are also highlighted...
- Miniaturization and parallelization of biological and chemical assays in microfluidic devicesSaurabh Vyawahare
Microfluidics Laboratory, Physical Sciences Oncology Center, Physics Department, Princeton University, Princeton, NJ 08544, USA
Chem Biol 17:1052-65. 2010Microfluidic systems are an attractive solution for the miniaturization of biological and chemical assays...
- Fast-scanning two-photon fluorescence imaging based on a microelectromechanical systems two- dimensional scanning mirrorWibool Piyawattanametha
James H Clark Center for Biomedical Engineering and Sciences, Stanford University, Stanford, California 94305, USA
Opt Lett 31:2018-20. 2006..Using such scanners we demonstrated two-photon microscopy and microendoscopy with fast-axis acquisition rates up to 3.52 kHz...
- A personal ultrasound imager (ultrasound stethoscope). A revolution in the physical cardiac diagnosis!J R T C Roelandt
Department of Cardiology, Thoraxcentre, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
Eur Heart J 23:523-7. 2002
- A miniature head-mounted two-photon microscope. high-resolution brain imaging in freely moving animalsF Helmchen
Biological Computation Research Department, Bell Laboratories, Lucent Technologies, Murray Hill, NJ 07974, USA
Neuron 31:903-12. 2001..Capillary blood flow and dendritic calcium transients were measured with high time resolution using line scans. In awake, freely moving rats, stable imaging was possible except during sudden head movements...
- From micro- to nanofabrication with soft materialsS R Quake
Department of Applied Physics, MS 128 95, California Institute of Technology, Pasadena, CA 91125, USA
Science 290:1536-40. 2000....
- Ligand assays: from electrophoresis to miniaturized microarraysR P Ekins
Division of Molecular Endocrinology, University College London Medical School, United Kingdom
Clin Chem 44:2015-30. 1998..The latter--applicable both to immunoassay and to DNA/RNA analysis--are likely to revolutionize the diagnostic and pharmaceutical fields in the next decade...
- Miniaturization of asymmetrical flow field-flow fractionation and application to studies on lipoprotein aggregation and fusionGebrenegus Yohannes
Laboratory of Analytical Chemistry, Department of Chemistry, University of Helsinki, FIN 00014 Helsinki, Finland
Anal Biochem 354:255-65. 2006..2 to 7.4, but treatment of LDL with alpha-chymotrypsin, sphingomyelinase, or copper sulfate leads to the formation of aggregated and fused LDL particles...
- Miniaturization and validation of a high-throughput serine kinase assay using the AlphaScreen platformAchim Von Leoprechting
Perkin Elmer LAS Germany GmbH, Rodgau Jügesheim, Germany
J Biomol Screen 9:719-25. 2004..In this study, the authors describe the feasibility of miniaturization of a serine kinase assay using generic reagents in the AlphaScreen format...
- Hand-held echocardiography: added value in clinical cardiological assessmentGiovanna Giannotti
Division of Cardiology, University of Siena, Italy
Cardiovasc Ultrasound 3:7. 2005..The aim of the study was to verify if the routine use of a basic model of echocardiographic Hand Held Device (HHD) could be an important diagnostic tool during outpatient cardiologic consulting or in non-cardiologic hospital sections...
- On-chip culture system for observation of isolated individual cellsI Inoue
Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, 16-723A Komaba 3-8-1, Meguro, Tokyo, 153-8902, Japan
Lab Chip 1:50-5. 2001....
- Hand-carried cardiac ultrasound (HCU) device: recommendations regarding new technology. A report from the Echocardiography Task Force on New Technology of the Nomenclature and Standards Committee of the American Society of EchocardiographyJames B Seward
American Society of Echocardiography, 1500 Sunday Drive, Suite 102, Raleigh, NC 27607, USA
J Am Soc Echocardiogr 15:369-73. 2002..However, appropriate user-specific training (Level 1 at a minimum) and assumption of responsibility are essential to ensure the most accurate acquisition, interpretation, and use of the data...
- First experiences with a new miniaturised life support system for mobile percutaneous cardiopulmonary bypassMatthias Arlt
Department of Anaesthesiology, University Hospital Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
Resuscitation 77:345-50. 2008....
- Silicon microsystems for neuroscience and neural prosthesesKensall D Wise
Department of Electrical Engineering and Computer Science, The University of Michigan, Ann Arbor, MI 48109 2122, USA
IEEE Eng Med Biol Mag 24:22-9. 2005
- Economy, speed and size matter: evolutionary forces driving nuclear genome miniaturization and expansionThomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Ann Bot 95:147-75. 2005....
- Towards miniaturization of a structural genomics pipeline using micro-expression and microcoil NMRWolfgang Peti
The Scripps Research Institute, Department of Molecular Biology and the Joint Center of Structural Genomics, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Struct Funct Genomics 6:259-67. 2005..Here, we outline ways towards miniaturization of a structural genomics pipeline with NMR screening for folded globular proteins, using a high-density micro-..
- Liquid phase interfacing and miniaturization in matrix-assisted laser desorption/ionization mass spectrometryFrantisek Foret
Institute of Analytical Chemistry, Czech Academy of Sciences, Brno, Czech Republic
Proteomics 2:360-72. 2002..This short review summarizes the state-of-the-art in the interface miniaturization and strategies for analysis of limited sample amounts by matrix assisted laser desorption/ionization mass ..
- Miniaturization of a high-throughput pLDH-based Plasmodium falciparum growth inhibition assay for small volume samples from preclinical and clinical vaccine trialsElke S Bergmann-Leitner
US Military Malaria Vaccine Program, Division of Malaria Vaccine Development, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
Am J Trop Med Hyg 78:468-71. 2008..This culture method can be extended beyond the pLDH-based readout to other techniques commonly used to determine growth/invasion inhibition...
- Noncontact infrared-mediated thermocycling for effective polymerase chain reaction amplification of DNA in nanoliter volumesA F Huhmer
Department of Chemistry, University of Virginia, Charlottesville 22901, USA
Anal Chem 72:5507-12. 2000..This sets the stage for microchip integration of the PCR process in the nanoliter volumes routinely manipulated in electrophoretic microchips...
- Exploiting the benefits of miniaturization for the enhancement of DNA microarraysJohan Vanderhoeven
Vrije Universiteit Brussel, Department of Chemical Engineering, Brussels, Belgium
Electrophoresis 25:3677-86. 2004..this task, as it allows to induce strongly enhanced lateral transport rates, independently of the degree of miniaturization of the hybridization chamber...
- Nanowire nanosensors for highly sensitive and selective detection of biological and chemical speciesY Cui
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
Science 293:1289-92. 2001..The small size and capability of these semiconductor nanowires for sensitive, label-free, real-time detection of a wide range of chemical and biological species could be exploited in array-based screening and in vivo diagnostics...
- Novel electrical detection of label-free disease marker proteins using piezoresistive self-sensing micro-cantileversKyung Wook Wee
Microsystem Research Center, Korea Institute of Science and Technology KIST, Seoul 136 791, Republic of Korea
Biosens Bioelectron 20:1932-8. 2005..This indicated that the self-sensing micro-cantilever approach is beneficial for detecting disease markers, and our piezoresistive micro-cantilever sensor system is applicable to miniaturized biosensor systems...
- A high density microelectrode array biosensor for detection of E. coli O157:H7Stephen M Radke
Biosystems and Agricultural Engineering, Michigan State University, 204 Farrall Hall, East Lansing, MI 48823, USA
Biosens Bioelectron 20:1662-7. 2005..coli O157:H7 detection in pure culture and inoculated food samples. The biosensor was able to discriminate between cellular concentrations of 10(4)-10(7)CFU/mL and has applications in detecting pathogens in food samples...
- A system-on-chip digital pH meter for use in a wireless diagnostic capsulePaul A Hammond
Department of Electronics and Electrical Engineering, University of Glasgow, Glasgow G12 8LT, UK
IEEE Trans Biomed Eng 52:687-94. 2005..The single-chip pH meter can be directly connected to a personal computer, and gives a response of 37 bits/pH, within an operating range of 7 pH units...
- Micro coulter counters with platinum black electroplated electrodes for human blood cell sensingSiyang Zheng
Department of Electrical Engineering, Division of Engineering and Applied Sciences, California Institute of Technology, Pasadena, CA 91125, USA
Biomed Microdevices 10:221-31. 2008..Further development of the devices can lead to the development of a highly-sensitive and high-throughput handheld blood counting system for point-of-care applications...
- Miniaturization of a biomedical gas sensorPeyman Mirtaheri
The Interventional Center, Rikshospitalet University Hospital, 0027 Oslo, Norway
Physiol Meas 25:1511-22. 2004..The result from this study will be applied for the industrial manufacturing of such a biomedical sensor as a clinical product...
- Miniaturized pH biosensors based on electrochemically modified electrodes with biocompatible polymersBoris Lakard
LCMI, UFR Sciences, Universite de Franche Comte, 16 route de Gray, Besançon 25030, France
Biosens Bioelectron 19:595-606. 2004..We have also successfully studied the potentiometric responses to pH changes of this device over a period of 1 month, and so we propose this new pH micro-biosensor as an alternative to classical pH sensors currently used in dermatology...
- Multiwell micromechanical cantilever array reader for biotechnologyR Zhang
Max Planck Institute for Polymer Research, Ackermannweg 10, D 55128, Mainz, Germany
Rev Sci Instrum 78:084103. 2007..Using this device, the adsorption of thiolated DNA molecules and 6-mercapto-1-hexanol on gold surfaces was performed to test the nanomechanical response of MCS...
- Integrated potentiostat for neurotransmitter sensing. A high sensitivity, wide range VLSI design and chipKartikeya Murari
Johns Hopkins School of Medicine, Baltimore, Maryland, USA
IEEE Eng Med Biol Mag 24:23-9. 2005
- Flat-chip microanalytical enzyme sensor for salivary amylase activityMasaki Yamaguchi
Department of Material Systems Engineering and Life Science, Faculty of Engineering, Toyama University, 3190 Gofuku, Toyama 930 8555, Japan
Biomed Microdevices 7:295-300. 2005..97 was fabricated with a sample volume of 50 microl. This research indicates the possibility of a wearable biosensor for continuous monitoring of salivary amylase activity...
- Development of a nanomechanical biosensor for analysis of endocrine disrupting chemicalsPampa Dutta
Department of Chemistry, University of Tennessee, 420 Buehler Hall, Knoxville, Tennessee 37996 1600, USA
Lab Chip 7:1184-91. 2007..Calibration plots for a MC functionalized with anti-17-beta-estradiol Ab show responses in the range of 1 x 10(-11) through 1 x 10(-7) M for 17-beta-estradiol with a linear portion extending over two orders of magnitude in concentration...
- Considerations in the design and sensitivity optimization of the micro tactile sensorYoshinobu Murayama
College of Engineering, Nihon University, Koriyama, Fukushima 963 8642, Japan
IEEE Trans Ultrason Ferroelectr Freq Control 52:434-8. 2005Although miniaturization has been considered the only technology with which to increase sensitivity of tactile sensors, we recently developed the micro tactile sensor (MTS) that performs with high sensitivity without microfabrication...
- Novel micromachined silicon sensor for continuous glucose monitoringG Piechotta
Fraunhofer Institute for Silicon Technology, Fraunhoferstr 1, 25524 Itzehoe, Germany
Biosens Bioelectron 21:802-8. 2005..In clinical trials the sensor measured continuously in interstitial fluid for up to 18 h without any signal drift and with good correlation to blood glucose reference values...
- Economic bismuth-film microsensor for anodic stripping analysis of trace heavy metals using differential pulse voltammetrySophie Legeai
Laboratoire d Electrochimie Analytique, Universite Claude Bernard Lyon I, 69622 Villeurbanne Cedex, France
Anal Bioanal Chem 383:839-47. 2005..Moreover, further study should be conducted to evaluate the potential of BiFE for analysis of several pollutants of interest that are usually determined electrochemically by using mercury-based electrodes...
- A novel micro tensile tester with feed-back control for viscoelastic analysis of single isolated smooth muscle cellsKazuaki Nagayama
Biomechanics Laboratory, Department of Mechanical Engineering, Nagoya Institute of Technology, Gokiso cho, Showa Ku, Nagoya 466 8555, Japan
Med Eng Phys 29:620-8. 2007..E.M.) which was over six times longer than that reported for vascular endothelial cells and fibroblasts...
- Micromachined sensor for lactate monitoring in salivaC G J Schabmueller
Fraunhofer Institut for Silicon Technology, Fraunhoferstrasse 1, 25524 Itzehoe, Germany
Biosens Bioelectron 21:1770-6. 2006..The novel approach enables a location independent, permanent real-time measurement of the lactate concentration during exercise...
- A compact electric potential sensor array for the acquisition and reconstruction of the 7-lead electrocardiogram without electrical charge contact with the skinC J Harland
Centre for Physical Electronics and Quantum Technology, School of Science and Technology, University of Sussex, Brighton, Sussex BN1 9QT, UK
Physiol Meas 26:939-50. 2005..We suggest that these ECG arrays, which are simple to apply, should prove to be a valuable tool in providing useful information about the state of the heart...
- In vivo chemical investigation of human skin using a confocal Raman fiber optic microprobeL Chrit
L Oreal Recherche, Aulanay sous Bois, France
J Biomed Opt 10:44007. 2005..Further improvement of the confocal probe would be to adapt a 360-deg configuration enabling access to other anatomical sites...
- A novel piezoelectric quartz micro-array immunosensor for detection of immunoglobulinEChunyan Yao
Department of Clinical Laboratory, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
J Nanosci Nanotechnol 6:3828-34. 2006..The correlation coefficient is 0.94 between ELISA and PZ immunosensor. After regeneration with NaOH the coated immunosensor can be reused 6 times without appreciable loss of activity...
- Towards a truly biomimetic olfactory microsystem: an artificial olfactory mucosaJ A Covington
University of Warwick, School of Engineering, Coventry, UK
IET Nanobiotechnol 1:15-21. 2007..We believe such emulation of the olfactory system can lead to improved odour discrimination within the field of electronic noses...
- Electrical detection of human immunoglobulins G from human serum using a microbiosensorLionel Marcon
Institut d Electronique de Microelectronique et de Nanotechnologie, UMR CNRS 8520, Dpt ISEN, 41 Bd Vauban, 59046 Lille Cedex, France
Biosens Bioelectron 23:81-7. 2007..Different capture efficiencies could be easily distinguished. The biosensor described here is easy to use and thus can be applied to real detection experiments...
- Microtubular conductometric biosensor for ethanol detectionA K Ajay
Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India
Biosens Bioelectron 23:281-4. 2007..The sensor shows minor interference with other functional groups and alcohols. The possible causes for such interference have been discussed...
- Evaluation of fully 3-D emission mammotomography with a compact cadmium zinc telluride detectorCaryl N Brzymialkiewicz
Multi Modality Imaging Laboratory, Department of Biomedical Engineering, Duke University Medical Center, DUMC 3949, Durham, NC 27710, USA
IEEE Trans Med Imaging 24:868-77. 2005..In practice, the sampling requirement may be less strict than initially anticipated...
- Miniaturized dynamic light scattering instrumentation for use in microfluidic applicationsThomas Q Chastek
Polymers Division, National Institute of Standards and Technology, 100 Bureau Drive Gaithersburg, Maryland 20899 8542, USA
Rev Sci Instrum 78:072201. 2007..Further capabilities include temperature control, demonstrated by identification of a critical micelle temperature of poly(ethylene oxide-b-propylene oxide-b-ethylene oxide), as well as multiangle DLS measurements...
- Investigating chorion softening of zebrafish embryos with a microrobotic force sensing systemDeok Ho Kim
Microsystems Research Center, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul 130 650, Republic of Korea
J Biomech 38:1359-3. 2005..The results mechanically quantitate "chorion softening" in zebrafish embryos due to protease activities subtly modifying the chorion structure, providing an understanding of zebrafish embryo development...
- Micromachined oxygen gas sensors for microscopic energy consumption measurement systemsC C Wu
Department of Electrical Engineering, National Cheng Kung University, Tainan, 701, Taiwan
J Med Eng Technol 29:278-87. 2005..These characteristics render the proposed sensor suitable for use within a microscopic energy consumption measurement system in either hospital or homecare environments...
- Quartz crystal microbalance based on torsional piezoelectric resonatorsW Bücking
Institute of Physical Chemistry, Clausthal University of Technology, Arnold Sommerfeld Strasse 4, D 38678 Clausthal Zellerfeld, Germany
Rev Sci Instrum 78:074903. 2007..Details of the geometry matter if the viscoelastic properties of the sample are of interest...
- Micromechanical cantilever array sensors for selective fungal immobilization and fast growth detectionNatalia Nugaeva
Institute of Physics, University of Basel, Klingelbergstrasse 82, Switzerland
Biosens Bioelectron 21:849-56. 2005..The measured shift is proportional to the mass of single fungal spores and can be used to evaluate spore contamination levels. Applications lie in the field of medical and agricultural diagnostics, food- and water-quality monitoring...
- Microchamber array based DNA quantification and specific sequence detection from a single copy via PCR in nanoliter volumesYasutaka Matsubara
School of Materials Science, Japan Advanced Institute of Science and Technology, 1 1 Asahidai, Tatsunokuchi, Nomi gun, Ishikawa 923 1292, Japan
Biosens Bioelectron 20:1482-90. 2005..Such a small device is surely a strong candidate for low-cost DNA amplification, and detected as little as 0.4 copies of target DNA...
- AMON: a wearable multiparameter medical monitoring and alert systemUrs Anliker
Wearable Laboratory, Electronics Laboratory, Swiss Federal Institute of Technology ETH Zentrum, Zurich CH 8092, Switzerland
IEEE Trans Inf Technol Biomed 8:415-27. 2004..The paper describes the main concepts behind the AMON system and presents details of the individual subsystems and solutions as well as the results of the medical validation...
- Calorimetric biosensors with integrated microfluidic channelsYuyan Zhang
Department of Electrical Engineering, The Pennsylvania State University, University Park, PA 16802, USA
Biosens Bioelectron 19:1733-43. 2004..This paper presents the design, fabrication and initial testing results from such a microthermopile-based thermal biosensor...
- A low-voltage wide-input CMOS comparator for sensor application using back-gate techniqueYu Cherng Hung
Department of Electrical Engineering, National Cheng Kung University, Tainan 70101, Taiwan, ROC
Biosens Bioelectron 20:53-9. 2004..Type-II comparator achieves 5 mV identified resolution. The input dynamic ranges of the comparators are approximately rail-to-rail...
- DNA detection by integrable electronicsC Guiducci
DEIS, University of Bologna, Bologna, Italy
Biosens Bioelectron 19:781-7. 2004..The sensitivity, the reliability, and the reproducibility of this device have been evaluated by experiments performed with a (non-integrated) prototype implementation, easily integrable in IC and/or micro-fabricated lab-on-a-chip...
- High frequency piezoelectric MEMS ultrasound transducersIoanna G Mina
Materials Research Laboratory, Pennsylvania State University, University Park, PA, USA
IEEE Trans Ultrason Ferroelectr Freq Control 54:2422-30. 2007..35-microm process technology. The ultrasound front-end chip contains beam-forming electronics, receiver circuitry, and analog-to-digital converters with 3-Kbyte on-chip buffer memory...
- Fabrication and characterization of annular thickness mode piezoelectric micro ultrasonic transducersRobert A Dorey
Microsystems and Nanotechnology Centre, Materials Department, Cranfield University, Cranfield, Bedfordshire, UK
IEEE Trans Ultrason Ferroelectr Freq Control 54:2462-8. 2007..Full analysis of these results will be conducted in later publications...
- A micromachined capillary electrophoresis chip with fully integrated electrodes for separation and electrochemical detectionRalph Wilke
Institute for Microtechnology, Technical University of Braunschweig, Alte Salzdahlumer Str 203, 38124 Braunschweig, Germany
Biosens Bioelectron 19:149-53. 2003..All three oxidizable species could be detected in less than 70 s. Glucose was detected by performing an enzymatic reaction along the separation channel. The microsystem showed a very good reproducibility...
- A novel silicon array designed for intraoperative charged particle imagingMartin P Tornai
Section of Nuclear Medicine, Department of Radiology, Duke University Medical Center and Department of Biomedical Engineering, Duke University, Durham, North Carolina 27710, USA
Med Phys 29:2529-40. 2002....
- Miniature sensor suitable for electronic nose applicationsLal A Pinnaduwage
Oak Ridge National Laboratory, P O Box 2008, Oak Ridge, TN 37831 6122, USA
Rev Sci Instrum 78:055101. 2007..The sensor can detect parts-per-trillion concentrations of DMMP within 10 s exposure times. The small size of the sensor makes it ideally suited for electronic nose applications...
- Highly specific label-free protein detection from lysed cells using internally referenced microcantilever sensorsWenmiao Shu
Nanoscience Centre, University of Cambridge, 11 JJ Thomson Avenue, Cambridge CB3 0FF, UK
Biosens Bioelectron 24:233-7. 2008..Similar experiments conducted with quartz crystal microbalance (QCM) technology are consistent with the response observed using microcantilever sensors...
- Nucleic acid purification using microfabricated silicon structuresNathaniel C Cady
Department of Microbiology, Cornell University, 317 Stocking Hall, Ithaca, NY 14853, USA
Biosens Bioelectron 19:59-66. 2003....
- MOSFET dosimetry for microbeam radiation therapy at the European Synchrotron Radiation FacilityE Brauer-Krisch
European Synchrotron Radiation Facility, B P 220, 38043 Grenoble, France
Med Phys 30:583-9. 2003..These results lend credence to the use of MOSFET detector systems in edge-on mode for microplanar irradiation dosimetry...
- Planar microcoil-based microfluidic NMR probesC Massin
Institute of Microelectronics and Microsystems, EPFL Swiss Federal Institute of Technology Lausanne, BM 3 108, Lausanne CH 1015, Switzerland
J Magn Reson 164:242-55. 2003..Finally, based on the presented model and measured data, future performance of planar microcoil-based microfluidic NMR probes is extrapolated and discussed...
- Functionalized biomicroelectromechanical systems sensors for force response study at local adhesion sites of single living cells on substratesM Taher A Saif
Department of Mechanical and Industrial Engineering, University of Illinois at Urbana Champaign, 1206 W Green Street, Urbana, IL 61801, USA
Ann Biomed Eng 31:950-61. 2003..Their force-deformation response shows strong linearity. Several possible mechanisms are discussed to explain the linear response...
- Glucose microbiosensor based on alumina sol-gel matrix/electropolymerized composite membraneXiaohong Chen
Department of Chemistry, University of Kansas, Malott Hall, Lawrence, KS 66045 0046, USA
Biosens Bioelectron 17:1005-13. 2002..The resulting glucose sensor was characterized by a short response time (<10 s), high sensitivity (10.4 nA/mM mm(2)), low interference from endogenous electroactive species, and a working lifetime of at least 60 days...
- Single-step electrochemical method for producing very sharp Au scanning tunneling microscopy tipsDavid Gingery
Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA
Rev Sci Instrum 78:113703. 2007..The addition of perchloric acid to sodium chloride solutions drastically shortens etching times and is shown by transmission electron microscopy to produce very sharp tips with a mean radius of curvature of 15 nm...
- A new dynamic electrochemical transduction mechanism for interdigitated array microelectrodesXiaoshan Zhu
MicroSystems and BioMEMS Lab, Dept of Electrical and Computer Engineering and Computer Science, University of Cincinnati, OH 45221 0030, USA
Lab Chip 4:581-7. 2004..The detection limit of p-aminophenol was calculated to be approximately 4 x 10(-7) M for the sensor with the new dynamic transduction mechanism...
- High-sensitivity miniaturized immunoassays for tumor necrosis factor alpha using microfluidic systemsSandro Cesaro-Tadic
IBM Research GmbH, Zurich Research Laboratory, Saumerstrasse 4, CH 8803 Ruschlikon, Switzerland
Lab Chip 4:563-9. 2004..6 mm(2) on PDMS to detect TNF-alpha in 600 nL of a dendritic cell (DC) culture medium with a sensitivity of approximately 20 pg mL(-1)(1.14 pM)...
- Microfabricated high-throughput electronic particle detectorD K Wood
Department of Physics, University of California at Santa Barbara, Santa Barbara, California 93106, USA
Rev Sci Instrum 78:104301. 2007....
- MULTI IMAGER COMPATIBLE ROBOT FOR PROSTATE ACCESSDan Stoianovici; Fiscal Year: 2004..Innovative engineering research will address design miniaturization, adequate material selection and manufacturing...
- A New Integrated Endoscope SystemLih Y Lin; Fiscal Year: 2010..and 3-dismentional imaging capability;(2) maintaining high resolution over various imaging depths;(3) probe miniaturization;(4) the weak intrinsic contrast between normal tissue and pre- or early cancers;and (5) the lack of molecular ..
- A New Integrated Endoscope SystemLIH LIN; Fiscal Year: 2009..and 3-dismentional imaging capability; (2) maintaining high resolution over various imaging depths; (3) probe miniaturization; (4) the weak intrinsic contrast between normal tissue and pre- or early cancers; and (5) the lack of ..
- Awareness Enhancement and Monitoring Device for Treatment of TrichotillomaniaJoseph Himle; Fiscal Year: 2007..In Phase II, the technology will continue to be developed for miniaturization and manufacturability and we will extend this body of research with human studies conducted on individuals ..
- FUNCTION OF NOGGIN IN HAIR FOLLICLE GROWTH AND DISEASEVladimir Botchkarev; Fiscal Year: 2006..disorders (androgenic alopecia and alopecia areata) are characterized by the development of hair follicle miniaturization with significant elongation of the resting stage, shortening of the growth stage of hair cycle, and hair loss...
- A ROLE FOR NOGGIN AND BMP2/4 IN HAIR GROWTH CONTROLVladimir Botchkarev; Fiscal Year: 2003..most common hair growth disorder (androgenic alopecia and alopecia areata) are characterized by hair follicle miniaturization with significant elongation of the resting stage, shortening of the growth stage of the hair cycle, and hair ..
- Magnetic Nanoparticles for Advanced Hearing DevicesCharles Seeney; Fiscal Year: 2002..Clinical advancement of IHD technology could be achieved through miniaturization of the magnetic implants...
- Label-free Immunoassay-based Sensor Array for Assessment of Exposure to PAHsJINSEONG KIM; Fiscal Year: 2007..Current trends in the development of immunoassay methodologies are miniaturization, multiple detection, and automation...
- POLYMER PARTICLES AS SEPARATION MEDIA FOR CHROMATOGRAPHYJEAN FRECHET; Fiscal Year: 2005..trend of rapid decrease in size of samples available for separations, our research will push even further the miniaturization of polymer-based separation technology using microcolumns and packed capillaries...
- Novel Assay for Ethylene Glycol ToxicityHANS KLOEPFER; Fiscal Year: 2002..To make such a level of miniaturization and simplicity feasible, we have developed a capillary fill sampling technique permitting specimen dosing, ..
- Blur, Accommodation, and VisionMartin S Banks; Fiscal Year: 2010..One set of experiments will use miniaturization effects developed in photography...
- VAGAL GASTRIC MOTOR CONTROL IN MICEELITA PARTOSEOEDARSO; Fiscal Year: 2002..This proposal will enable us to surmount the difficulties associated with physiological miniaturization. Thus we will be able to exploit genetically engineered mice using state-of-the-art equipment for measuring ..
- Development of a High Throughput Genotoxicity AssayNEAL HUEBOTTER; Fiscal Year: 2004..Sensitive detection of mutagenically induced revertants allows for the miniaturization and incorporation of the assay into a 96- or 384-well format for rapid simultaneous genotoxicity screening of ..
- Implantable PV ECG Telemetry SystemHuntly Millar; Fiscal Year: 2007..The specific aims of this Phase II effort are: a) miniaturization of the application specific integrated circuit (ASIC), b...
- New Materials for High Efficiency Protein SeparationsMary J Wirth; Fiscal Year: 2010..The combined miniaturization and higher field promises a combined 100-fold increase in speed along each dimension of the separation to ..
- Real-Time and Quantitative Determination of GenesWeihong Tan; Fiscal Year: 2006..The biosensor development will mainly emphasize purity of MB, new design for surface immobilization, miniaturizatIon, better understanding of the surface bound MBs in hybridization, better application of the MB sensors in a ..
- Micromachined Fluid Transfer Devices for Molecular ScreeningROBERT HAUSHALTER; Fiscal Year: 2006..High throughput experiments such as compound library reformatting, nanoliter fluid transfer, assay miniaturization and molecular library screening would all greatly benefit from a more accurate and faster fluid transfer ..
- Technological Development Towards a Cortical ProsthesisPatrick Rousche; Fiscal Year: 2005Forty years ago, exciting advances in neuroscience, biomaterials, electronics and miniaturization fueled development of the cochlear implant, the world's first and most successful auditory neuroprosthesis...
- Micro-Robotics for Minimally-Invasive NeurosurgeryJAMES GOLDIE; Fiscal Year: 2004..Moreover, since there is a tradeoff between strength/stability and miniaturization, the project will show how the optimum design point in this tradeoff space depends on the particulars of the ..
- Thin Film Magnetic Sensors for Ultrathin Bronchoscope NavigationERIK LANGE; Fiscal Year: 2006..They are generally too large for use in ultrathin bronchoscopes and are unsuitable for further miniaturization. The proposed program uses solid-state thin-film giant magneto-resistive (GMR) magnetic field sensors to ..
- NON-INVASIVE PNEUMOTHORAX DETECTORDANIEL KELSCH; Fiscal Year: 2007..The next steps in commercialization of this device are to complete the miniaturization and integration with the PDA, complete the clinical study, and apply to the FDA for 510(k) clearance to ..
- Insulating Coatings for Implant Devices and Ribbon CablesHELMUT ECKHARDT; Fiscal Year: 2007Summary Advancements in device miniaturization, integrated circuits packaging, microfabrication technologies, and biocompatible materials have made possible the development of complex neural prostheses designed to restore lost functions ..
- LIQUID CHROMATOGRAPHY OF BIOLOGICAL SUBSTANCESCsaba Horvath; Fiscal Year: 2003..Both capillaries and chips represent the trend of miniaturization of analytical instrumentation...