mining

Summary

Top Publications

  1. pmc Outbreak of fatal childhood lead poisoning related to artisanal gold mining in northwestern Nigeria, 2010
    Carrie A Dooyema
    Healthy Homes and Lead Poisoning Prevention Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Health Perspect 120:601-7. 2012
  2. pmc Intellectual function in Mexican children living in a mining area and environmentally exposed to manganese
    Horacio Riojas-Rodriguez
    Dirección de Salud Ambiental, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    Environ Health Perspect 118:1465-70. 2010
  3. ncbi Evidence of declining STD prevalence in a South African mining community following a core-group intervention
    R Steen
    AIDSCAP Family Health International, Nairobi, Kenya
    Sex Transm Dis 27:1-8. 2000
  4. ncbi Cause of death and presence of respiratory disease at autopsy in an HIV-1 seroconversion cohort of southern African gold miners
    Jill Murray
    National Institute for Occupational Health, PO Box 4788, Johannesburg2000, South Africa
    AIDS 21:S97-S104. 2007
  5. ncbi Lineages of acidophilic archaea revealed by community genomic analysis
    Brett J Baker
    Department of Earth and Planetary Sciences, University of California, Berkeley, CA 94720, USA
    Science 314:1933-5. 2006
  6. ncbi Mercury as a serious health hazard for children in gold mining areas
    Stephan Bose-O'Reilly
    Institute of Public Health, Medical Decision Making and Health Technology Assessment, UMIT University for Health Sciences, Medical Informatics and Technology, Eduard Wallnoefer Zentrum I, A 6060 Hall i T, Austria
    Environ Res 107:89-97. 2008
  7. ncbi HIV and STIs in clients and female sex workers in mining regions of Gejiu City, China
    Jun Jie Xu
    National Center for AIDS STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
    Sex Transm Dis 35:558-65. 2008
  8. ncbi Heterogeneity of malaria prevalence in alluvial gold mining areas in Northern Mato Grosso State, Brazil
    Alisson Flávio Barbieri
    Centro de Desenvolvimento e Planejamento Regional, Universidade Federal de Minas Gerais, Rua Curitiba 832, Belo Horizonte, MG 30170, Brazil
    Cad Saude Publica 23:2878-86. 2007
  9. pmc The diesel exhaust in miners study: I. Overview of the exposure assessment process
    Patricia A Stewart
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
    Ann Occup Hyg 54:728-46. 2010
  10. ncbi Changing patterns of knowledge, reported behaviour and sexually transmitted infections in a South African gold mining community
    Brian G Williams
    16 rue de la Canonniere, Geneva 1202, Switzerland
    AIDS 17:2099-107. 2003

Detail Information

Publications377 found, 100 shown here

  1. pmc Outbreak of fatal childhood lead poisoning related to artisanal gold mining in northwestern Nigeria, 2010
    Carrie A Dooyema
    Healthy Homes and Lead Poisoning Prevention Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Health Perspect 120:601-7. 2012
    ..In May 2010, a team of national and international organizations was assembled to investigate children's deaths due to lead poisoning in villages in northwestern Nigeria...
  2. pmc Intellectual function in Mexican children living in a mining area and environmentally exposed to manganese
    Horacio Riojas-Rodriguez
    Dirección de Salud Ambiental, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    Environ Health Perspect 118:1465-70. 2010
    ..Excessive exposure to manganese (Mn), an essential trace element, has been shown to be neurotoxic, especially when inhaled. Few studies have examined potential effects of Mn on cognitive functions of environmentally exposed children...
  3. ncbi Evidence of declining STD prevalence in a South African mining community following a core-group intervention
    R Steen
    AIDSCAP Family Health International, Nairobi, Kenya
    Sex Transm Dis 27:1-8. 2000
    To reduce the prevalence of curable sexually transmitted diseases (STDs) in a South African mining community through provision of STD treatment services, including periodic presumptive treatment and prevention education to a core group of ..
  4. ncbi Cause of death and presence of respiratory disease at autopsy in an HIV-1 seroconversion cohort of southern African gold miners
    Jill Murray
    National Institute for Occupational Health, PO Box 4788, Johannesburg2000, South Africa
    AIDS 21:S97-S104. 2007
    ..To describe causes of death and respiratory infections in HIV-infected miners in the pre-antiretroviral era, by duration of HIV infection...
  5. ncbi Lineages of acidophilic archaea revealed by community genomic analysis
    Brett J Baker
    Department of Earth and Planetary Sciences, University of California, Berkeley, CA 94720, USA
    Science 314:1933-5. 2006
    ..45 micrometers in diameter is dominated by these organisms. Transmission electron microscope images revealed that the cells are pleomorphic with unusual folded membrane protrusions and have apparent volumes of <0.006 cubic micrometer...
  6. ncbi Mercury as a serious health hazard for children in gold mining areas
    Stephan Bose-O'Reilly
    Institute of Public Health, Medical Decision Making and Health Technology Assessment, UMIT University for Health Sciences, Medical Informatics and Technology, Eduard Wallnoefer Zentrum I, A 6060 Hall i T, Austria
    Environ Res 107:89-97. 2008
    In many developing countries, mercury is used to extract gold from ore in small-scale mining areas...
  7. ncbi HIV and STIs in clients and female sex workers in mining regions of Gejiu City, China
    Jun Jie Xu
    National Center for AIDS STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
    Sex Transm Dis 35:558-65. 2008
    To investigate HIV/sexually transmitted infections (STIs) among female sex workers (FSWs) and clients in a mining region of China.
  8. ncbi Heterogeneity of malaria prevalence in alluvial gold mining areas in Northern Mato Grosso State, Brazil
    Alisson Flávio Barbieri
    Centro de Desenvolvimento e Planejamento Regional, Universidade Federal de Minas Gerais, Rua Curitiba 832, Belo Horizonte, MG 30170, Brazil
    Cad Saude Publica 23:2878-86. 2007
    This paper analyzes factors affecting the risk of malaria among individuals working in wildcat gold mining camps (garimpos) in northern Mato Grosso State in the Brazilian Amazon...
  9. pmc The diesel exhaust in miners study: I. Overview of the exposure assessment process
    Patricia A Stewart
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
    Ann Occup Hyg 54:728-46. 2010
    ..Air monitoring surveys at seven of the eight study mining facilities were conducted between 1998 and 2001 and provided reference personal REC exposure levels and ..
  10. ncbi Changing patterns of knowledge, reported behaviour and sexually transmitted infections in a South African gold mining community
    Brian G Williams
    16 rue de la Canonniere, Geneva 1202, Switzerland
    AIDS 17:2099-107. 2003
    In 1998, a major HIV intervention project was started in a mining community in Carletonville, South Africa...
  11. pmc Metabolic diversity among main microorganisms inside an arsenic-rich ecosystem revealed by meta- and proteo-genomics
    Philippe N Bertin
    Genetique Moleculaire, Génomique et Microbiologie, UMR7156 CNRS and UdS, Strasbourg, France
    ISME J 5:1735-47. 2011
    ....
  12. pmc Vermiculite, respiratory disease, and asbestos exposure in Libby, Montana: update of a cohort mortality study
    Patricia A Sullivan
    Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Environ Health Perspect 115:579-85. 2007
    ..Asbestos-contaminated Libby vermiculite was used in loose-fill attic insulation that remains in millions of homes in the United States, Canada, and other countries...
  13. ncbi Health assessment of artisanal gold miners in Tanzania
    Stephan Bose-O'Reilly
    Institute of Public Health, Medical Decision Making and Health Technology Assessment, UMIT University for Health Sciences, Medical Informatics and Technology, Eduard Wallnoefer Center I, A 6060 Hall i T, Austria
    Sci Total Environ 408:796-805. 2010
    ..Nations Industrial Development Organization) conducted an environmental and health assessment in a small-scale mining area in Tanzania. BGS (British Geological Survey) performed the environmental assessment...
  14. pmc Geomicrobiology of La Zarza-Perrunal acid mine effluent (Iberian Pyritic Belt, Spain)
    Elena Gonzalez-Toril
    Centro de Astrobiología INTA CSIC, Carretera de Ajalvir Km 4, Torrejon de Ardoz, 28850 Madrid, Spain
    Appl Environ Microbiol 77:2685-94. 2011
    ..Taking into consideration the characteristics of this acidic extreme environment and the physiological properties and spatial distribution of the identified microorganisms, a geomicrobiological model of this ecosystem is advanced...
  15. ncbi Biogeochemical changes induced in uranium mining waste pile samples by uranyl nitrate treatments under anaerobic conditions
    A Geissler
    Institute of Radiochemistry, Forschungszentrum Dresden Rossendorf, Dresden, Germany
    Geobiology 7:282-94. 2009
    Response of the subsurface soil bacterial community of a uranium mining waste pile to treatments with uranyl nitrate over different periods of time was studied under anaerobic conditions...
  16. ncbi Health assessment of artisanal gold miners in Indonesia
    Stephan Bose-O'Reilly
    Institute of Public Health, Medical Decision Making and Health Technology Assessment, UMIT University for Health Sciences, Medical Informatics and Technology, Eduard Wallnoefer Center I, A 6060 Hall i T, Austria
    Sci Total Environ 408:713-25. 2010
    ..Less exposed mineral processors and the general population in the mining areas were also intoxicated to a high percentage.
  17. pmc Linking geological and health sciences to assess childhood lead poisoning from artisanal gold mining in Nigeria
    Geoffrey S Plumlee
    US Geological Survey, Denver, Colorado 80225, USA
    Environ Health Perspect 121:744-50. 2013
    ..In 2010, Médecins Sans Frontières discovered a lead poisoning outbreak linked to artisanal gold processing in northwestern Nigeria. The outbreak has killed approximately 400 young children and affected thousands more...
  18. ncbi Exposure and toxic effects of elemental mercury in gold-mining activities in Ecuador
    Raul Harari
    Corporación Para el Desarrollo de la Producción y el Medio Ambiente Laboral Institute for the Development of Production and the Work Environment, P O Box 17 08 8386, Domingo de Brieva N38 107 y Villalengua, Urbanización Granda Centeno, Quito, Ecuador
    Toxicol Lett 213:75-82. 2012
    Traditional gold mining, using metallic mercury (Hg(0)) to form gold amalgam, followed by burning to remove the Hg(0), is widely used in South America, Africa and Asia...
  19. ncbi Metal contamination of soils and crops affected by the Chenzhou lead/zinc mine spill (Hunan, China)
    Hongyu Liu
    LMTG, CNRS Université Paul Sabatier IRD UMR 5563, 14 Avenue Edouard Belin, 31400 Toulouse, France
    Sci Total Environ 339:153-66. 2005
    In 1985, the collapse of the tailing dam in Chenzhou lead/zinc mine (Hunan, southern China) led to the spread of mining waste spills on the farmland along the Dong River...
  20. ncbi Copper mining in Streptomyces: enzymes, natural products and development
    Jonathan A R Worrall
    Department of Biological Sciences, University of Essex, Colchester, CO4 3SQ, UK
    Nat Prod Rep 27:742-56. 2010
    ....
  21. ncbi South African experience with asbestos related environmental mesothelioma: is asbestos fiber type important?
    Neil White
    UCT Lung Institute and Department of Medicine, University of Cape Town, P O Box 34560, Groote Schuur 7937, South Africa
    Regul Toxicol Pharmacol 52:S92-6. 2008
    ..In the vast majority of these cases, exposure was linked to crocidolite mining activities in the Northern Cape Province...
  22. ncbi Control of malaria vectors with the insect growth regulator pyriproxyfen in a gem-mining area in Sri Lanka
    A M Yapabandara
    Regional Office, Anti-Malaria Campaign, Matale, Sri Lanka
    Acta Trop 80:265-76. 2001
    ....
  23. ncbi Asbestos exposure and mesothelioma in South Africa
    D Rees
    National Centre for Occupational Health, University of the Witwatersrand, Johannesburg
    S Afr Med J 89:627-34. 1999
    ....
  24. pmc A new chemolithoautotrophic arsenite-oxidizing bacterium isolated from a gold mine: phylogenetic, physiological, and preliminary biochemical studies
    J M Santini
    Department of Microbiology, La Trobe University, Bundoora, Victoria 3083, Australia
    Appl Environ Microbiol 66:92-7. 2000
    ..This recently discovered organism is the most rapidly growing chemolithoautotrophic arsenite oxidizer known...
  25. pmc Macroscopic streamer growths in acidic, metal-rich mine waters in north wales consist of novel and remarkably simple bacterial communities
    Kevin B Hallberg
    School of Biological Sciences, University of Wales, Bangor LL57 2UW, United Kingdom
    Appl Environ Microbiol 72:2022-30. 2006
    ....
  26. pmc Contemporary environmental variation determines microbial diversity patterns in acid mine drainage
    Jia Liang Kuang
    State Key Laboratory of Biocontrol and Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat Sen University, Guangzhou, People s Republic of China
    ISME J 7:1038-50. 2013
    ..Collectively, our results suggest that microbial diversity patterns are better predicted by contemporary environmental variation rather than geographical distance in extreme AMD systems...
  27. ncbi AMD biofilms: using model communities to study microbial evolution and ecological complexity in nature
    Vincent J Denef
    Department of Earth and Planetary Science, University of California, Berkeley, CA, USA
    ISME J 4:599-610. 2010
    ..We discuss the value and limitations of tractable model microbial communities in developing molecular methods for microbial ecology and in uncovering principles that may explain behavior in more complex systems...
  28. doi Mining and other threats to the New Caledonia biodiversity hotspot
    Michel Pascal
    INRA, Station SCRIBE, Campus de Beaulieu, F 35 042 Rennes Cedex, France
    Conserv Biol 22:498-9. 2008
  29. ncbi Oscillating migration and the epidemics of silicosis, tuberculosis, and HIV infection in South African gold miners
    David Rees
    Occupational Medicine Division, National Institute for Occupational Health, National Health Laboratory Service, Johannesburg, South Africa
    Am J Ind Med 53:398-404. 2010
    ..This is termed oscillating or circular migration. Today we have serious interrelated epidemics of silicosis, tuberculosis, and HIV infection in the gold mining industry.
  30. ncbi Mercury exposure and public health
    Jack C Clifton
    Great Lakes Center for Children s Environmental Health, John H Stroger, Jr Hospital of Cook County, Chicago, IL, USA
    Pediatr Clin North Am 54:237-69, viii. 2007
    ....
  31. pmc The Diesel Exhaust in Miners Study: II. Exposure monitoring surveys and development of exposure groups
    Joseph B Coble
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
    Ann Occup Hyg 54:747-61. 2010
    Air monitoring surveys were conducted between 1998 and 2001 at seven non-metal mining facilities to assess exposure to respirable elemental carbon (REC), a component of diesel exhaust (DE), for an epidemiologic study of miners exposed to ..
  32. ncbi The Mt. Diwata study on the Philippines 1999--assessing mercury intoxication of the population by small scale gold mining
    G Drasch
    Institute for Forensic Medicine, Ludwig Maximilians University, Munich, Germany
    Sci Total Environ 267:151-68. 2001
    ..A reduction of the external Hg burden on Mt. Diwata is urgently recommended. An attempt to treat the intoxicated participants with the chelating agent dimercaptopropanesulfonic acid (DMPS) is planned...
  33. pmc The Diesel Exhaust in Miners study: a cohort mortality study with emphasis on lung cancer
    Michael D Attfield
    ERS Inc, Morgantown, WV, USA
    J Natl Cancer Inst 104:869-83. 2012
    ..Current information points to an association between diesel exhaust exposure and lung cancer and other mortality outcomes, but uncertainties remain...
  34. ncbi In situ evolutionary rate measurements show ecological success of recently emerged bacterial hybrids
    Vincent J Denef
    Department of Earth and Planetary Science, University of California, Berkeley, CA 94720, USA
    Science 336:462-6. 2012
    ..The ecological success of hybrid bacterial types highlights the role of evolutionary processes in rapid adaptation within natural microbial communities...
  35. ncbi High percentage inorganic arsenic content of mining impacted and nonimpacted Chinese rice
    Y G Zhu
    Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Environ Sci Technol 42:5008-13. 2008
    ..Two of the sites were within mining and smeltery districts, and the third was devoid of large-scale metal processing industries...
  36. pmc The Diesel Exhaust in Miners Study: IV. Estimating historical exposures to diesel exhaust in underground non-metal mining facilities
    Roel Vermeulen
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
    Ann Occup Hyg 54:774-88. 2010
    ..for an epidemiologic study of mortality, including lung cancer, among diesel-exposed miners at eight non-metal mining facilities [the Diesel Exhaust in Miners Study (DEMS)]...
  37. pmc Mercury exposure, serum antinuclear/antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study
    Renee M Gardner
    Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, Baltimore, MD 21205, USA
    Environ Res 110:345-54. 2010
    ..We have reported elevated levels of ANA and ANoA in human populations exposed to mercury in artisanal gold mining, though other confounding variables that may also modulate ANA/ANoA levels were not well controlled...
  38. pmc Methylmercury neurotoxicity in Amazonian children downstream from gold mining
    P Grandjean
    Department of Environmental Medicine, Odense University, Odense, Denmark
    Environ Health Perspect 107:587-91. 1999
    In widespread informal gold mining in the Amazon Basin, mercury is used to capture the gold particles as amalgam. Releases of mercury to the environment have resulted in the contamination of freshwater fish with methylmercury...
  39. pmc Characterization of Ferroplasma isolates and Ferroplasma acidarmanus sp. nov., extreme acidophiles from acid mine drainage and industrial bioleaching environments
    Mark Dopson
    School of Biological Sciences Centre for Ecology, Evolution and Conservation, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    Appl Environ Microbiol 70:2079-88. 2004
    ..F. acidarmanus" Fer1(T) groups separately, and we propose the new species "F. acidarmanus" Fer1(T) sp. nov...
  40. ncbi An archaeal iron-oxidizing extreme acidophile important in acid mine drainage
    K J Edwards
    Department of Geology and Geophysics, University of Wisconsin Madison, 1215 West Dayton Street, Madison, WI 53706, USA
    Science 287:1796-9. 2000
    ..The presence of this and other closely related Thermoplasmales suggests that these acidophiles are important contributors to acid mine drainage and may substantially impact iron and sulfur cycles...
  41. ncbi Diversity and community structure of culturable arsenic-resistant bacteria across a soil arsenic gradient at an abandoned tungsten-tin mining area
    Angel Valverde
    Instituto de Recursos Naturales y Agrobiología de Salamanca CSIC, Apartado 257, 37071 Salamanca, Spain
    Chemosphere 85:129-34. 2011
    ..It was also shown that, under aerobic conditions, strains with relatively enhanced tolerance to As(III) predominated over the most As(V)-tolerant ones...
  42. pmc Fluid losses and hydration status of industrial workers under thermal stress working extended shifts
    D J Brake
    Occup Environ Med 60:90-6. 2003
    ....
  43. pmc The asbestos cancer epidemic
    Joseph LaDou
    Division of Occupational and Environmental Medicine, University of California San Francisco School of Medicine, 350 Parnassus Avenue, Suite 609, San Francisco, CA 94117, USA
    Environ Health Perspect 112:285-90. 2004
    ..The WHO and the ILO continue to fail to address the problem of asbestos mining, manufacturing, and use and world trade of a known human carcinogen...
  44. pmc Spatial and temporal analysis of the microbial community in the tailings of a Pb-Zn mine generating acidic drainage
    Li Nan Huang
    Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, Sun Yat Sen Zhongshan University, Guangzhou 510275, People s Republic of China
    Appl Environ Microbiol 77:5540-4. 2011
    ..were consistently present in the acidic tailings, acidophilic archaea, mostly Ferroplasma acidiphilum, were predominant in the oxidized zones and the oxidation front, indicating their importance to generation of acid mine drainage...
  45. ncbi Impacts of lead/zinc mining and smelting on the environment and human health in China
    Xiuwu Zhang
    Department of Environmental Geography and Human Health, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Science, Beijing, 100101, China
    Environ Monit Assess 184:2261-73. 2012
    b>Mining and smelting are important economic activities. However, mining-related industries are also some of the largest sources of environmental pollution from heavy metals...
  46. ncbi Could the bug Triatoma sherlocki be vectoring Chagas disease in small mining communities in Bahia, Brazil?
    C E Almeida
    Laboratório de Biodiversidade Entomológica, Instituto Oswaldo Cruz FIOCRUZ IOC Fiocruz, Rio de Janeiro, Brazil
    Med Vet Entomol 23:410-7. 2009
    ..was described in the municipality of Gentio do Ouro, in the state of Bahia, Brazil, and in a small artisan quarry-mining community approximately 13 km distant in a remote area of the same municipality...
  47. ncbi The prokaryotic community of a historically mining-impacted tropical stream sediment is as diverse as that from a pristine stream sediment
    Mariana P Reis
    Departamento de Biologia Geral, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, Belo Horizonte, MG, Brazil
    Extremophiles 17:301-9. 2013
    b>Mining negatively affects the environment by producing large quantities of metallic tailings, such as those contaminated with arsenic, with harmful consequences for human and aquatic life...
  48. ncbi Health risk associated with dietary co-exposure to high levels of antimony and arsenic in the world's largest antimony mine area
    Fengchang Wu
    State Key Laboratory of Environmental Criteria and Risk Assessment, State Environmental Protection Key Laboratory for Lake Pollution Control, Chinese Research Academy of Environmental Sciences, Beijing 100012, China
    Sci Total Environ 409:3344-51. 2011
    ..In addition, this pilot study did not consider the possible Sb and As combined effects...
  49. ncbi Environmental impacts and metal exposure of aquatic ecosystems in rivers contaminated by small scale gold mining: the Puyango River basin, southern Ecuador
    N H Tarras-Wahlberg
    Graduate School, Department of Geography, University of Cambridge, United Kingdom
    Sci Total Environ 278:239-61. 2001
    Gold mining in the Portovelo-Zaruma district in southern Ecuador is causing considerable environmental impacts; the most important ones are related to the discharge of cyanide, mercury and metal rich tailings into rivers of the Puyango ..
  50. ncbi Bacterial diversity based on 16S rRNA and gyrB genes at Yinshan mine, China
    Huaqun Yin
    School of Minerals Processing and Bioengineering, Central South University, Changsha, Hunan, China
    Syst Appl Microbiol 31:302-11. 2008
    ..Moreover, the Mantel test showed that the geochemical characteristics, especially the pH value and the concentration of iron, strongly influenced the composition of the microbial communities...
  51. ncbi Heavy metal contamination from mining sites in South Morocco: 1. Use of a biotest to assess metal toxicity of tailings and soils
    Ali Boularbah
    Departement de Biologie, Faculté des Sciences et Techniques Guéliz, Universite Cadi Ayyad, Boulevard Abdelkrim Khattabi, BP 549, 40 000 Marrakech, Morocco
    Chemosphere 63:802-10. 2006
    ..Therefore, the MetPAD test can be used as a rapid and sensitive predictive tool to assess the heavy metal availability in soils highly contaminated by mining activities.
  52. ncbi Genetic influences on the retention of inorganic mercury
    Hipolito M Custodio
    Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
    Arch Environ Occup Health 60:17-23. 2005
    ..These results indicate that genotypes with decreased GSH availability for mercury conjugation affect the metabolism of inorganic mercury...
  53. ncbi Characterization of Fe plaque and associated metals on the roots of mine-waste impacted aquatic plants
    C M Hansel
    Department of Geological and Environmental Sciences, Stanford University, California 94305, USA
    Environ Sci Technol 35:3863-8. 2001
    ..As such, hydrated iron oxides, bacterial biofilms, and metal carbonates will influence the availability and mobility of metals within the rhizosphere of aquatic plants...
  54. pmc How a masculine work ethic and economic circumstances affect uptake of HIV treatment: experiences of men from an artisanal gold mining community in rural eastern Uganda
    Godfrey E Siu
    MRC Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK
    J Int AIDS Soc 15:1-9. 2012
    ....
  55. ncbi Geomicrobiology of extremely acidic subsurface environments
    David Barrie Johnson
    School of Biological Sciences, Bangor University, Bangor, UK
    FEMS Microbiol Ecol 81:2-12. 2012
    ..Wooden pit props, submerged in the underground lake, act as a slow-release source of organic carbon in the subterranean Mynydd Parys lake, supporting a microbial community that is more enriched with heterotrophic microorganisms...
  56. ncbi Environmental assessment of mercury contamination from the Rwamagasa artisanal gold mining centre, Geita District, Tanzania
    H Taylor
    British Geological Survey, Geochemistry, Minerals and Hydrology, Kingsley Dunham Centre, Keyworth, Nothingham, NG12 5GG, UK
    Sci Total Environ 343:111-33. 2005
    ..presents the results of an environmental assessment of mercury (Hg) contamination in the Rwamagasa artisanal gold mining area, northwest Tanzania, and the potential downstream dispersion along the River Malagarasi to Lake Tanganyika...
  57. ncbi Leukemia and exposure to ionizing radiation among German uranium miners
    Matthias Möhner
    Federal Institute for Occupational Safety and Health BAuA, Berlin, Germany
    Am J Ind Med 49:238-48. 2006
    ..It is well known that uranium miners are at an increased risk of lung cancer. Whether they also have an increased risk for other cancer sites remains under discussion. The aim of this study was to examine the leukemia risk among miners...
  58. ncbi Acid mine drainage remediation options: a review
    D Barrie Johnson
    School of Biological Sciences, University of Wales, Bangor LL57 2UW, UK
    Sci Total Environ 338:3-14. 2005
    Acid mine drainage (AMD) causes environmental pollution that affects many countries having historic or current mining industries...
  59. ncbi Cadmium and lead in bovine milk in the mining area of the Caudal River (Spain)
    José Ramiro González-Montaña
    Medicine, Surgery and Anatomy Veterinary Department, Veterinary Faculty, University of Leon, Campus de Vegazana, 24071, Leon, Spain
    Environ Monit Assess 184:4029-34. 2012
    ..All the farms were located in Asturias (Spain), a zone of great industrial and mining activity in the proximities of the Caudal River...
  60. pmc Systematics and species-specific response to pH of Oxytricha acidotolerans sp. nov. and Urosomoida sp. (Ciliophora, Hypotricha) from acid mining lakes
    Thomas Weisse
    Institute for Limnology of the Austrian Academy of Sciences, 5310 Mondsee, Austria
    Eur J Protistol 49:255-71. 2013
    ..nov. and Urosomoida sp. (Ciliophora, Hypotricha) isolated from two chemically similar acid mining lakes (pH~2.6) located at Langau, Austria, and in Lusatia, Germany. Oxytricha acidotolerans sp. nov...
  61. ncbi Assessment of Hg contamination and exposure to miners and schoolchildren at a small-scale gold mining and recovery operation in Thailand
    S Umbangtalad
    Environmental Engineering and Management Program, School of Environment Resources and Development, Asian Institute of Technology, Pathumthani, Thailand
    J Environ Sci Health A Tox Hazard Subst Environ Eng 42:2071-9. 2007
    ..Small-scale gold mining operations have been carried out since the year 2000 in Phanom Pha District, Phichit Province, Thailand...
  62. ncbi Occupational health hazards in mining: an overview
    A M Donoghue
    Alcoa World Alumina Australia, Applecross, Perth, WA 6953, Australia
    Occup Med (Lond) 54:283-9. 2004
    ..article outlines the physical, chemical, biological, ergonomic and psychosocial occupational health hazards of mining and associated metallurgical processes...
  63. pmc Asbestos-related disease in South Africa: the social production of an invisible epidemic
    Lundy Braun
    Department of Africana Studies and Pathology and Laboratory Medicine, Brown University, Providence, RI 02910, USA
    Am J Public Health 96:1386-96. 2006
    ..As a consequence of particularly exploitative social conditions, former workers and residents of mining regions suffered--and continue to suffer--from a serious yet still largely undocumented burden of asbestos-related ..
  64. ncbi Biodiversity and geochemistry of an extremely acidic, low-temperature subterranean environment sustained by chemolithotrophy
    Sakurako Kimura
    School of Biological Sciences, College of Natural Sciences, Bangor University, Deiniol Road, Bangor, LL57 2UW, UK
    Environ Microbiol 13:2092-104. 2011
    ..ferrivorans and acidophilic iron-oxidizing Betaproteobacteria) in mediating mineral oxidation and redox transformations of iron in acidic, low-temperature environments...
  65. ncbi Ecology. Danger of deep-sea mining
    Jochen Halfar
    Department of Chemical and Physical Sciences, University of Toronto at Mississauga, Mississauga, Ontario, Canada, L5L 1C6
    Science 316:987. 2007
  66. ncbi Cultivation-dependent and cultivation-independent characterization of the microbial community in acid mine drainage associated with acidic Pb/Zn mine tailings at Lechang, Guangdong, China
    Gui Liang Tan
    State Key Laboratory of Biocontrol, School of Life Sciences, University of Wales, UK
    FEMS Microbiol Ecol 59:118-26. 2007
    ..Thus, the present study extends our knowledge of the biodiversity of microorganisms populating highly acidic AMD environments...
  67. pmc GeoChip-based analysis of the functional gene diversity and metabolic potential of microbial communities in acid mine drainage
    Jianping Xie
    School of Mineral Processing and Bioengineering, Central South University, Changsha, Hunan 410083, China
    Appl Environ Microbiol 77:991-9. 2011
    ..This study presents an overview of functional gene diversity and the structure of AMD microbial communities and also provides insights into our understanding of metabolic potential in AMD ecosystems...
  68. ncbi Contamination status of arsenic and other trace elements in drinking water and residents from Tarkwa, a historic mining township in Ghana
    Kwadwo Ansong Asante
    Center for Marine Environmental Studies, Ehime University, Bunkyo cho 2 5, Matsuyama, Ehime 790 8577, Japan
    Chemosphere 66:1513-22. 2007
    ..assess the contamination status of 22 trace elements, especially As in water and residents in Tarkwa, a historic mining town in Ghana...
  69. ncbi High human exposure to cobalt and other metals in Katanga, a mining area of the Democratic Republic of Congo
    Célestin Lubaba Nkulu Banza
    Unité de Toxicologie et Environnement, Ecole de Santé Publique, Université de Lubumbashi, Democratic Republic of Congo
    Environ Res 109:745-52. 2009
    The human health impact of the historic and current mining and processing of non-ferrous metals in the African Copperbelt is not known...
  70. ncbi HIV/AIDS prevalence testing--merits, methodology and outcomes of a survey conducted at a large mining organisation in South Africa
    W Stevens
    Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg
    S Afr Med J 96:134-9. 2006
    ..To determine the HIV prevalence rate at Anglo Platinum, a large, multinational organisation operating in South Africa (Gauteng, Limpopo and North-West), and to assess the merits, methodology and outcomes of the survey...
  71. ncbi The influence of radon exposures on lung cancer mortality in German uranium miners, 1946-2003
    Linda Walsh
    Federal Office for Radiation Protection, Department Radiation Protection and Health, 85764 Oberschleissheim, Germany
    Radiat Res 173:79-90. 2010
    Extensive uranium extraction took place from 1946 until 1990 at the former Wismut mining company in East Germany...
  72. pmc In situ proteo-metabolomics reveals metabolite secretion by the acid mine drainage bio-indicator, Euglena mutabilis
    David Halter
    UMR7156 Université de Strasbourg CNRS, Genetique Moleculaire, Génomique et Microbiologie, Département Micro organismes, Génomes, Environnement, Strasbourg, France
    ISME J 6:1391-402. 2012
    ..mutabilis. Consequently, this protist may have an indirect but important role in AMD ecosystems but also in other ecological niches often described as nitrogen-limited...
  73. ncbi Decreases in depression over 20 years in a mining area of Sardinia: due to selective migration?
    Mauro Giovanni Carta
    Centro di Psichiatria di Consultazione e Psicosomatica, Azienda Ospedaliero Universitaria di Cagliari, University of Cagliari, Italy
    J Affect Disord 141:255-60. 2012
    ..The objective of the study was to determine if community surveys, conducted 3 times over a period of 20 years in a small district of Sardinia (Italy), confirm the increase in depressive disorders reported in the recent literature...
  74. ncbi Role of methylmercury exposure (from fish consumption) on growth and neurodevelopment of children under 5 years of age living in a transitioning (tin-mining) area of the western Amazon, Brazil
    Rejane C Marques
    Escola de Enfermagem Anna Nery, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Arch Environ Contam Toxicol 62:341-50. 2012
    Human occupation of the Amazon region has recently increased, bringing deforestation for agriculture and open-cast mining, activities that cause environmental degradation and pollution...
  75. ncbi Sleep and circadian rhythms in mining operators: limited evidence of adaptation to night shifts
    Sally A Ferguson
    Centre for Sleep Research, University of South Australia, Australia
    Appl Ergon 43:695-701. 2012
    ..The current study followed twenty-nine operators at a live-in mining operation working to a seven-day, seven-night shift pattern who collected saliva samples for melatonin measurement,..
  76. ncbi Retrospective exposure assessment for respirable and inhalable dust, crystalline silica and arsenic in the former German uranium mines of SAG/SDAG Wismut
    D Dahmann
    Institut für Gefahrstoff Forschung, IGF, Bochum, Germany
    Int Arch Occup Environ Health 81:949-58. 2008
    ..to the end of the 1990s, an extensive series of retrospective exposure investigations for the East German uranium mining industry was performed in order to provide information about the exposure situation of the miners towards ..
  77. ncbi The Mt. Diwata study on the Philippines 2000-treatment of mercury intoxicated inhabitants of a gold mining area with DMPS (2,3-dimercapto-1-propane-sulfonic acid, Dimaval)
    S Bose-O'Reilly
    Institute of Forensic Medicine, Ludwig Maximilians University, Munich, Germany
    Sci Total Environ 307:71-82. 2003
    Ninty-five inhabitants of the gold mining area of Mt. Diwata (on Mindanao, Philippines), who were diagnosed to be mercury (Hg) intoxicated, were orally treated with 2 x 200 mg of the chelating agent DMPS (Dimaval, Co...
  78. ncbi Comparison of ferric iron generation by different species of acidophilic bacteria immobilized in packed-bed reactors
    Owen F Rowe
    School of Biological Sciences, University of Wales, Bangor LL57 4UF, UK
    Syst Appl Microbiol 31:68-77. 2008
    ....
  79. ncbi Evaluation of genotoxic effects of heavy metals and arsenic in wild nestling white storks (Ciconia ciconia) and black kites (Milvus migrans) from southwestern Spain after a mining accident
    Raquel Baos
    Department of Applied Biology, Estación Biológica de Doñana C S I C, Avda Ma Luisa s n Pabellón del Perú, 41013 Sevilla, Spain
    Environ Toxicol Chem 25:2794-803. 2006
    Studies of birds from Doñana (southwestern Spain) after the Aznalcóllar mining accident (April 1998) have reported high levels of genetic damage when compared to conspecifics from reference areas...
  80. ncbi Ischemic heart disease mortality among miners and other potentially silica-exposed workers
    Jan Weiner
    Swedish Work Environment Authority, Solna, Sweden
    Am J Ind Med 50:403-8. 2007
    ..Some previous studies have observed an increased mortality regarding ischemic heart disease (IHD) among miners and industrial sand workers. The purpose was to study the occurrence of IHD mortality among silica-exposed workers...
  81. ncbi Use of fluoroquinolone antibiotics leads to tuberculosis treatment delay in a South African gold mining community
    C Y Jeon
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Int J Tuberc Lung Dis 15:77-83. 2011
    ..Empiric use of fluoroquinolone (FQ) antibiotics could delay tuberculosis (TB) treatment and lead to FQ-resistant TB...
  82. pmc Gold mining in the Peruvian Amazon: global prices, deforestation, and mercury imports
    Jennifer J Swenson
    Nicholas School of the Environment, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 6:e18875. 2011
    ..We find that since 2003, recent mining deforestation in Madre de Dios, Peru is increasing nonlinearly alongside a constant annual rate of increase in ..
  83. pmc Incidence of leukemia, lymphoma, and multiple myeloma in Czech uranium miners: a case-cohort study
    Vladimír Rericha
    Health Institute of the Uranium Industry, Príbram, Czech Republic
    Environ Health Perspect 114:818-22. 2006
    ..Uranium miners are chronically exposed to low levels of radon and its progeny. We investigated whether radon exposure is associated with increased incidence of leukemia, lymphoma, or multiple myeloma in this population...
  84. ncbi Heavy metal pollution of soils affected by the Guadiamar toxic flood
    F Cabrera
    Instituto de Recursos Naturales y Agrobiología de Sevilla CSIC, Spain
    Sci Total Environ 242:117-29. 1999
    ....
  85. ncbi Microbial diversity in uranium mining-impacted soils as revealed by high-density 16S microarray and clone library
    Gurdeep Rastogi
    Department of Chemical and Biological Engineering, South Dakota School of Mines and Technology, Rapid City, SD 57701, USA
    Microb Ecol 59:94-108. 2010
    Microbial diversity was characterized in mining-impacted soils collected from two abandoned uranium mine sites, the Edgemont and the North Cave Hills, South Dakota, using a high-density 16S microarray (PhyloChip) and clone libraries...
  86. pmc Community-level social support responses in a slow-motion technological disaster: the case of Libby, Montana
    Rebecca J W Cline
    School of Communication Studies, Kent State University, Kent, OH 44242, USA
    Am J Community Psychol 46:1-18. 2010
    ..Specifically, community-level conflict appears to interfere with previously established social support patterns. The observed phenomenon can be understood as the deterioration of a previously supportive community...
  87. pmc The Diesel Exhaust in Miners Study: III. Interrelations between respirable elemental carbon and gaseous and particulate components of diesel exhaust derived from area sampling in underground non-metal mining facilities
    Roel Vermeulen
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
    Ann Occup Hyg 54:762-73. 2010
    ..historical components of DE from side-by-side area measurements taken in underground operations of seven non-metal mining facilities...
  88. ncbi Factors associated with an increased case-fatality rate in HIV-infected and non-infected South African gold miners with pulmonary tuberculosis
    G J Churchyard
    Aurum Health Research, Welkom, Free State, South Africa
    Int J Tuberc Lung Dis 4:705-12. 2000
    A gold mining company in the Free State Province, South Africa.
  89. ncbi Estimating historical respirable crystalline silica exposures for Chinese pottery workers and iron/copper, tin, and tungsten miners
    Z Zhuang
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, US Department of Health and Human Services, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Ann Occup Hyg 45:631-42. 2001
    ..The exposure matrix of the historical Chinese total dust concentrations was multiplied by these conversion factors to obtain an exposure matrix of historical respirable crystalline silica concentrations...
  90. ncbi Use of the modified BCR three-step sequential extraction procedure for the study of trace element dynamics in contaminated soils
    M Pueyo
    Departament de Quimica Analitica, Universitat de Barcelona, Marti i Franques 1 11, E 08028 Barcelona, Spain
    Environ Pollut 152:330-41. 2008
    ..Thus, the effectiveness of the BCR procedure has proved to be a useful tool for predicting short- and long-term mobility of trace elements, even in complex environmental scenarios...
  91. ncbi Inorganic carbon limitation and mixotrophic growth in Chlamydomonas from an acidic mining lake
    Jörg Tittel
    Institute of Biochemistry and Biology, University of Potsdam, Maulbeerallee 2, 14469 Potsdam, Germany
    Protist 156:63-75. 2005
    Plankton communities in acidic mining lakes (pH 2.5-3.3) are species-poor because they face extreme environmental conditions, e.g. 150mg l(-1) Fe2+ +Fe3+...
  92. ncbi Effect of HIV on work-related injury rates in South African gold miners
    Jill Murray
    National Institute for Occupational Health, National Health Laboratory Service, Johannesburg, South Africa
    AIDS 19:2019-24. 2005
    ..The objective was to calculate the effect of HIV on the rate and severity of work-related injuries by duration of infection...
  93. pmc Behavioural development of school-aged children who live around a multi-metal sulphide mine in Guangdong province, China: a cross-sectional study
    Qing Song Bao
    Department of Food Safe Supervision, Health Inspection and Supervision Center, 205 Renmin South Road, Yixing, PR China
    BMC Public Health 9:217. 2009
    ..The present study aimed to estimate relationships between measured multi-metal exposures and the presence of behavioural problems for the school-aged children in the polluted area...
  94. ncbi Community proteomics of a natural microbial biofilm
    Rachna J Ram
    Department of Environmental Science, Policy, and Management, University of California at Berkeley, Berkeley, CA 94720, USA
    Science 308:1915-20. 2005
    ..We validated and estimated the relative abundance and cellular localization of 357 unique and 215 conserved novel proteins and determined that one abundant novel protein is a cytochrome central to iron oxidation and AMD formation...
  95. ncbi Radon: a likely carcinogen at all exposures
    S Darby
    Clinical Trial Service Unit, University of Oxford, UK
    Ann Oncol 12:1341-51. 2001
    ..Radon is a well-established lung carcinogen that has been extensively studied. Very high concentrations can occur in some underground mines. Concentrations also tend to build up in homes...
  96. ncbi Soil As contamination and its risk assessment in areas near the industrial districts of Chenzhou City, Southern China
    Xiao yong Liao
    Center for Environmental Remediation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, PR China
    Environ Int 31:791-8. 2005
    ..Hence proper treatments for As contaminated soils are urgently needed to reduce the contamination...
  97. ncbi Microbial and mineralogical characterizations of soils collected from the deep biosphere of the former Homestake gold mine, South Dakota
    Gurdeep Rastogi
    Department of Chemical and Biological Engineering, South Dakota School of Mines and Technology, Rapid City, SD 57701, USA
    Microb Ecol 60:539-50. 2010
    ..High-density microarrays revealed the greatest prokaryotic diversity ever reported from deep subsurface habitat of gold mines...
  98. ncbi Incidence of tuberculosis and HIV and progression of silicosis and lung function impairment among former Basotho gold miners
    Harriet H Park
    International AIDS Vaccine Initiative, New York, New York, USA
    Am J Ind Med 52:901-8. 2009
    ..Pulmonary tuberculosis and HIV incidence, mortality, and the progression of silicosis and lung function impairment are described over a 1-year period in migrant ex-gold miners from Lesotho...
  99. ncbi Heavy metal mining using microbes
    Douglas E Rawlings
    Department of Microbiology, University of Stellenbosch, Private Bag X1, South Africa
    Annu Rev Microbiol 56:65-91. 2002
    ..The development of higher-temperature processes will extend the variety of minerals that can be commercially processed...
  100. ncbi A review of the federal government's health activities in response to asbestos-contaminated ore found in Libby, Montana
    Kevin Horton
    Agency for Toxic Substances and Disease Registry, Division of Health Studies, Surveillance and Registries Branch, Atlanta, Georgia 30333, USA
    Inhal Toxicol 18:925-40. 2006
    ..This article presents the various follow-up activities that have been conducted to date by ATSDR and partnering state health departments...
  101. pmc Exposure to silica and silicosis among tin miners in China: exposure-response analyses and risk assessment
    W Chen
    Department of Labor Health and Occupational Diseases, School of Public Health, Tonji Medical University, 13 Hang Kong Lu, Wuhan, Hubei, People s Republic of China
    Occup Environ Med 58:31-7. 2001
    ..To investigate the risk of silicosis among tin miners and to investigate the relation between silicosis and cumulative exposure to dust (Chinese total dust and respirable crystalline silica dust)...

Research Grants81

  1. Immunomodulatory and regenerative effects of mesenchymal stem cells on allografts
    Norma S Kenyon; Fiscal Year: 2013
    ..This team will provide a powerful mechanism for data mining and analysis, thereby resulting in acceleration of the discovery process, as compared to the outcome of a single ..
  2. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..To evaluate and compare exposure to diesel and biodiesel emissions and acute health effects in underground mining. Background: Despite mine ventilation and emission controls, underground miners are exposed to concentrations of ..
  3. Dietary Lipids and Silica-Accelerated Autoimmunity
    James J Pestka; Fiscal Year: 2013
    ..g. mining, construction, custodial and manufacturing industries) to silica...
  4. Endotoxin, the airway transcriptome, and obstructive lung disease
    PEGGY SUE LAI; Fiscal Year: 2013
    ..are to obtain further didactic training in environmental epidemiology, advanced biostatistics, genomics, and data mining, as well as practical skills in building a cohort, exposure assessment, obtaining biospecimens, nucleic extraction,..
  5. UNDERSTANDING VIBRATION INJURY
    Danny A Riley; Fiscal Year: 2013
    ..5 million workers use powered tools in the construction, manufacturing, agriculture-forestry and fishing, and mining Sectors and are currently exposed to levels of hand-arm vibration putting them at risk for developing hand-arm ..
  6. Expanded Testing Methods for Elements and Metals in Animal Diagnostic Specimens
    Timothy Baszler; Fiscal Year: 2013
    ..proposal have 14 extensive experience animal contamination events associated with the long established mineral 15 mining industry in the western United States...
  7. Biosynthesis of Microbial Isoprenoids
    David E Cane; Fiscal Year: 2013
    ..emphasis on the mechanistic and structural characterization of three broad classes of proteins uncovered by mining of genomic databases and functional gene expression that present novel structural, mechanistic, or biological ..
  8. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2012
    ..project we will build upon an ongoing birth cohort study of 750 mothers and their children at a former hard rock mining community, the Tar Creek, OK, Superfund mega-site...
  9. TNF-alpha Signaling in Silica-Induced Lung Fibrosis
    Luis A Ortiz; Fiscal Year: 2012
    ..a much higher mortality due to silicosis when compared to the rest of the country and clusters of counties (where mining is an important activity) around the city of Pittsburgh are identifiable that contribute disproportionably (>14...
  10. Role of AIB1 in malignant progression
    Anna Tate Riegel; Fiscal Year: 2013
    ..We will use data mining of human breast cancer array sets to determine if there are changes in the levels of the repressor associated with ..
  11. A Systems Biology Approach to the Model Apicomplexan Toxoplasma gondii
    William J Sullivan Jr; Fiscal Year: 2010
    ..genomics and other high throughput technologies (thematic area 1) with a systems-level integration, analysis and mining of large datasets with the overarching goal of translating our discoveries into new insights into therapy and ..
  12. Identification and Validation of Alcohol Biomarker Signatures by Proteomics
    Emanuel Rubin; Fiscal Year: 2010
    ..iv) To perform biostatistical and bioinformatics data mining for differential analysis of proteomic expression from rat and human samples, correlate global protein changes ..
  13. Abnormality in Gene Expression of Key Mediators of Vitamin A Action in COPD
    Salil K Das; Fiscal Year: 2010
    ..b>Mining of existing GEO datasets with microarray data from human COPD studies revealed expression differences for CRBP-1 ..
  14. Ionic Liquid Gas Sensors for Detection of Flammable Gases In Workplace
    Xiangqun Zeng; Fiscal Year: 2010
    ..are essential in occupational health and safety to prevent fire or explosion in gas facilities and underground mining. Three things are needed to support a fire or explosion: a source of fuel (e.g...
  15. Epigenomic regulation of metabolism in muscle by circadian clock and environment
    Zheng Sun; Fiscal Year: 2013
    ..This unbiased method will produce comprehensive datasets, from which data mining and motif analysis will generate new hypotheses regarding novel transcription networks that respond to exercise...
  16. DC-SIGN Inhibitors for the Treatment of HIV Infection
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ..three sources: HTS of in-house library, virtual screening of Zinc database, and "binding-site directed lipophilic mining" approach...
  17. Utilization of calcite for the reduction of coal mine dust toxicity
    Xi Huang; Fiscal Year: 2010
    ..be simultaneously achieved through multidisciplinary collaboration of Investigators from environmental medicine, mining and engineering, as well as geology...
  18. Virtual Screening Development to Complement Experimental Screening for PPAR Modul
    Stephanie N Lewis; Fiscal Year: 2012
    ..Therefore, we propose focusing drug discovery and design techniques on mining for natural compounds that bind to PPAR(...
  19. International Training and Research in Environmental and Occupational Health
    NELSON K STEENLAND; Fiscal Year: 2012
    ..Water contamination by metals is an important problem in both Peru and Chile, where mining has increased and mine wastes have contaminated water and soils Ongoing Fogarty studies funded under our current ..
  20. Developing, Validating, and Implementing a CKD Predictive Model (DELVECKD)
    KHALED A ABDEL-KADER; Fiscal Year: 2013
    ..This project will provide the applicant with valuable experience in data mining, medical informatics, decision analysis, health services research, and clinical trial design and implementation...
  21. Mining open chromatin to define molecular mechanisms of CF modifier genes
    WANDA K O'NEAL; Fiscal Year: 2013
    ....
  22. Non-invasive evaluation of Non-alcoholic Steatohepatitis
    Michelle Lai; Fiscal Year: 2013
    ..prediction and predictive modeling, cost-effectiveness and cost-benefit analysis, pharmacoeconomics, data mining, database and genetics and genomics...
  23. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
    ..confirm additional genes that promote neuronal plasticity and intracellular trafficking in the raphe, extend data mining of the current array results and probe new rhesus microarrays with laser captured serotonin neurons...
  24. HCMR Novel Markers of Prognosis in Hypertrophic Cardiomyopathy
    Stefan Neubauer; Fiscal Year: 2013
    ..the Specific Aim is to develop a predictive model of cardiovascular outcomes in HCM by: 1) using exploratory data mining methods to identify demographic, clinical, and novel CMR, genetic and biomarker variables associated with the ..
  25. Highly finished chromosome-based genome assembly for Anopheles gambiae
    Igor V Sharakhov; Fiscal Year: 2012
    ..The scientific community will be able to access the new assembly from VectorBase for further mining and functional characterization of the An. gambiae genome...
  26. In Silico Model for Acute Lung Injury Prediction and Clinical Trial Design
    Ognjen Gajic; Fiscal Year: 2010
    ..b) a rule based model to capture clinicians'putative knowledge and expertise, and c) a probabilistic/data mining model derived from empirical evidence extracted from electronic medical records and clinical trial databases...
  27. Molecular Phenotyping of NOD Mice
    Ivan C Gerling; Fiscal Year: 2010
    ..cluster analysis on combined molecular phenotype data files (using and further developing some novel analysis and mining approaches). Specific Aim 4...
  28. Chaperone Mining of the Chlamydia Type Three Secretion System
    ELLENA MARIE PETERSON; Fiscal Year: 2010
    ..Having an understanding of the critical elements of the Chlamydia TTS system should lead to the development of strategies to subvert the TTS system with the ultimate goal of attenuating or preventing infections with this pathogen. ..
  29. Research Training on Chronic Lung Diseases in Southern Africa
    Thomas G Robins; Fiscal Year: 2013
    ..g., silica associated with mining &construction industries, respirable dust in coal mines, allergens and endotoxin associated with agriculture ..
  30. Global Predictions and Tests of Erythroid Regulation
    Yu Zhang; Fiscal Year: 2013
    ..Our studies collecting genome-wide data on many biochemical features associated with gene regulation, mining the data deeply to predict functional DNA sequences, and experimentally testing those bioinformatic predictions ..
  31. Second Generation Small Molecule Inhibitors of Botulinum Neurotoxins
    Sina Bavari; Fiscal Year: 2013
    ..combine X-ray crystallography, in vitro and in vivo biological testing, molecular modeling and 3-D database mining, and organic chemistry to guide SMNPI discovery and optimization (i.e...
  32. Mechanisms of particulate chromium lung carcinogenesis
    SUSAN M CERYAK; Fiscal Year: 2011
    ..basic zinc chromate (ZnCrO44Zn(OH)2), which is an intermediately water soluble chromate typically encountered in mining and chromate production facilities and is also present as an environmental atmospheric contaminant in urban areas ..
  33. Family History, Genes, Environment and G X E Interaction in Predicting RA Risk
    Elizabeth W Karlson; Fiscal Year: 2013
    ..used an advanced informatics infrastructure to extract clinical data on RA diagnostic features through database mining and NLP. A highly specific algorithm was used to identify RA cases and collect samples from cases and controls...
  34. Catalytic Approach to Treatment of Cyanide Poisoning
    SIGRIDUR G SUMAN; Fiscal Year: 2010
    ..It is used industrially in tasks such as fumigation, electroplating, and mining, and accidental exposure can be life-threatening...
  35. Improving Methods for Comparative Effectiveness Research in Cardiovascular Care
    SOKO SETOGUCHI-IWATA; Fiscal Year: 2012
    ..HF and 2) develop and evaluate models for 3 analytic techniques A) high dimensional propensity score using data mining techniques, B) instrumental variable analysis, and C) propensity score calibration to combat bias due to lack of ..
  36. Comprehensive Clinical Decision Support for the Primary Care of Premature Infants
    Robert W Grundmeier; Fiscal Year: 2010
    ..The intervention will consist of (1) a real-time data mining tool functioning in the EHR that will organize large amounts of health information visually in a succinct time-..
  37. The translational program in oocyte and early embryo development
    Marco Conti; Fiscal Year: 2013
    ..By mining these data sets as well as published data, it is emerging that the oocyte synthesizes the machinery utilized in ..
  38. Identification of Responders to the FES Interventions in Stroke Population
    Rakesh Pilkar; Fiscal Year: 2013
    ..Finally, we will employ Principal Component Analysis (PCA) - an advanced data mining technique to track and quantify the overall gait recovery process of individuals with stroke using pattern ..
  39. Pursuing purine pathways to clinical trials for Parkinson's disease
    Michael A Schwarzschild; Fiscal Year: 2012
    ..clinical trial of the urate precursor inosine (designed to assess its safety and ability to elevate CSF urate) by mining the trial's biological and clinical databases, and by developing a Phase III efficacy trial based on its ..
  40. Effect of Crohn's Disease Risk Alleles on Enteric Microbiota
    Ellen Li; Fiscal Year: 2010
    ..Genetic probes for pathogenic commensal organisms developed by mining the bacterial genome data and shotgun sequencing data will be used to test the hypothesis that increased numbers ..
  41. Therapeutics that target processivity complex proteins of pox and other viruses
    ROBERT PAUL RICCIARDI; Fiscal Year: 2013
    ..Additional new analogs will be obtained by in silico Compound Mining. Medicinal Chemistry of select LEAD compounds will generate inhibitors of superior anti-viral potency and safety...
  42. One Health Innovation Fellowships for Zoonotic Disease Research In Mongolia
    GREGORY CHARLES GRAY; Fiscal Year: 2013
    ..Since moving to a market economy in 1992, Mongolia has undergone rapid change with increases in mining operations and animal production of sheep, goats, and cattle...
  43. Metabolomic Markers for Early Detection of Prostate Cancer
    Arun Sreekumar; Fiscal Year: 2010
    ..b>Mining this compendium has resulted in metabolomic signatures for localized prostate cancer and advanced disease...
  44. The role of SPARC in lung fibrosis
    Elizabeth A Putnam; Fiscal Year: 2013
    ..For almost 60 years Libby miners and residents were exposed to asbestos- contaminated vermiculite from a mining operation near town...
  45. Multiscale Framework for Molecular Heterogeneity Analysis
    Lee Cooper; Fiscal Year: 2013
    ..will be integrated through the Pathology Analytic Imaging Standards (PAIS) database to provide support for data mining analysis...
  46. Carbon Black Induced Activation of Lung APCs
    DAVID BRIAN CORRY; Fiscal Year: 2013
    ..g., tobacco) and constitutes an important form of pollution (e.g., through coal mining, the wearing of rubber tires, diesel exhaust, etc...
  47. Clinically Relevant Genome Variation Database
    Sharon E Plon; Fiscal Year: 2013
    ..will be disseminated through a user-friendly web Portal (vetted by Genetic Counseling WG), web services for data mining, and consensus clinical guidelines to the appropriate clinical and research communities...
  48. Mining the Multiple Sclerosis miRNome for Disease Markers
    Amy E Lovett Racke; Fiscal Year: 2010
    ..This study is designed to identify normally occurring microRNA that may be dysregulating, promoting autoimmunity. The data will enable us to identify new therapeutic targets and disease biomarkers for MS. ..
  49. Gene-Environment Interactions in an Autism Birth Cohort
    W Ian Lipkin; Fiscal Year: 2013
    ..and other iatrogenic factors;oxidative stress responses) and heritable susceptibilities, and prospective mining of the maternal and cord blood transcriptome and proteome for ASD biomarkers;(3) Investigate trajectories of ASD ..
  50. Developing Myxovirus Inhibitors with Expanded Pathogen Target Range
    Richard K Plemper; Fiscal Year: 2013
    ..In addition, a novel, innovative high-throughput screening protocol and data-mining of system-wide host-influenza interaction screens will be implemented to identify independent host targets and ..
  51. Beagle: A Supercomputer for Computational Biology, Simulation, and Data Analysis
    Ian Foster; Fiscal Year: 2010
    ..disease;the identification of genetic signatures for a wide array of inherited disorders;and large-scale text mining for both clinical discovery and characterization of knowledge creation and propagation in scientific communities...
  52. The Cardiopulmonary Effects of Particulate Exposure
    David C Christiani; Fiscal Year: 2013
    ..Our fourth aim is exploratory in which we will mine data mining from our existing gene expression results, and further assess the relationship between plasma profiles and the ..
  53. Can noise-induced TTS cause persistent impairment of speech understanding?
    Anthony Brammer; Fiscal Year: 2013
    ..and all NORA Sector Programs in which hearing loss may occur (Agriculture, Forestry, Construction, Manufacturing, Mining, and Transportation)...
  54. Proteome-wide cellular immunity approach to P. falciparum antigen identification
    ALESSANDRO D SETTE; Fiscal Year: 2012
    ..falciparum in the context of multiple genetic restrictions, by mining the P. falciparum genomic sequence...
  55. Pain Assessment & Intervention Needs (PAIN)
    Fern Fitzhenry; Fiscal Year: 2010
    ..The primary aim of the study is to analyze pain management by both hypothesis tests &data mining. Current pain management practice is informed with standards disseminated by the American Pain Society reflecting ..
  56. Genetics of struvite formation
    Leticia Reyes; Fiscal Year: 2010
    ..interdisciplinary group of mentors chosen for their approaches in infectious diseases, pathology, computer data mining, and bioinformatics...
  57. Tools for Linking and Mining image and Genomic Data in Non-Small Cell Lung Cancer
    SYLVIA KATINA PLEVRITIS; Fiscal Year: 2013
    ....
  58. Gene Dosage Imbalance in Neurodevelopmental Disorders
    David H Ledbetter; Fiscal Year: 2013
    ..genes responsible for these disorders with the following specific aims: 1) High-throughput CNV and phenotype data mining from large cohorts of patients with IDD/ASDs...
  59. Modulation of Biodefense Responses to Microbial Pathogens
    Anthony T Vella; Fiscal Year: 2013
    ..An innovative proteomic mining strategy will be used to test the novel hypothesis that T cell responses against enterotoxins guide a cell damage ..
  60. Algorithms and Image Analysis Software Tool for Automated Recognition and Identif
    JELENA KOVACEVIC; Fiscal Year: 2010
    ..While this trove hides answers to a host of important questions, mining it visually, as it is typically done, is an enormous and error-prone task wasting valuable resources...
  61. Yale SCOR on Gender-Sensitive Treatment for Tobacco Dependence
    SHERRY ANN MCKEE; Fiscal Year: 2013
    ..and gender differences in relation to smoking by providing expert consultation;supporting faculty training awards;mining national data on gender, smoking and health outcomes to inform health policy;and expanding our current program of ..
  62. CORE GRANT FOR VISION RESEARCH
    Christopher W Tyler; Fiscal Year: 2011
    ..research is the increasing reliance on highly computation-intensive analyses such as computational modeling, data mining and statistical analysis of large databases...
  63. International Program for Mining Health and Safety
    Jefferey Burgess; Fiscal Year: 2006
    ..DO NOT EXCEED THE SPACE PROVIDED. Objectives: To improve environmental and occupational health associated with mining operations andmineral processing in sub-Saharan Africa through training, research, prevention and intervention...
  64. Data Mining Assisted Discovery of Novel Organophosphorou
    Robert Turner; Fiscal Year: 2005
    ..Unfortunately, many if not most are not active organophosphate hydrolases. We have developed a data mining method for identifying active OPH's...
  65. Estrogenic activity of uranium in vitro and in vivo
    CHERYL DYER; Fiscal Year: 2007
    ..S. In the mid 1940's active uranium (U) mining began in the Four Corners region of the southwest U.S. where the Navajo Nation is located...
  66. Small Molecule Inhibitors of Anthrax Lethal Factor
    NORTON PEET; Fiscal Year: 2006
    ..molecule LF inhibitors through a combination of screening of chemical libraries and 3D sub-structure database mining. These inhibitors have been shown to specifically bind to LF with low (M potencies in enzymatic assays and to ..
  67. Advanced Computational Framework for Decision Support in Critically Ill Children
    Randall C Wetzel; Fiscal Year: 2010
    ..Using AI and automated computational methodology we will develop algorithms for data mining raw medical data from disparate clinical data sources...
  68. A SOCIAL NETWORK-BASED INTERVENTION TO REDUCE LEAD EXPOS
    Michelle Kegler; Fiscal Year: 2004
    ..effectiveness in mobilizing a Native American community to respond to heavy metal contamination from lead and zinc mining. Ottawa County Oklahoma, the site of the proposed research, was heavily mined for zinc and lead in the first half ..
  69. Arsenic Phytosensors
    Mark P Elless; Fiscal Year: 2010
    ..is often required to detect and monitor arsenic over large areas affected by activities such as pesticide use, mining, smelting, and construction with pressure-treated wood...
  70. EXPLOSION HAZARDS RELATED TO COMBUSTIBLE DUSTS
    CHARLES KAUFFMAN; Fiscal Year: 1992
    ..Traditionally these explosions have been associated with the agricultural and mining industries, but they have also occurred in other industries where a combustible dust is handled or generated, as ..
  71. Mining the Soil Metagenome for Novel Biodegradation Gen*
    Ronald Crawford; Fiscal Year: 2004
    ..abstract_text> ..
  72. Mining the Structural Genomics Initiative for Disorder
    A Dunker; Fiscal Year: 2009
    ..Alsoof importance is that this workwill significantly increase the sequence-function informationobtained from the structural genomics initiative with very little incremental increase over the current investment. ..
  73. Natural Language Processing for Cancer Research Network Surveillance Studies
    David Carrell; Fiscal Year: 2010
    ..HMO Cancer Research Network (CRN) of "industrial-strength" natural language processing (NLP) systems useful for mining valuable, research-grade information from unstructured clinical text...
  74. Root exudates as a new chemical-mining pool for isolation of novel antimicrobials
    Harsh P Bais; Fiscal Year: 2010
    ..It is expected that these novel efforts will lead to the development of new therapeutics for treatment of E. faecalis and E. faecium infections either by a stand-alone drug or by augmenting the effectiveness of existing drug therapies. ..
  75. SPATIALLY ORIENTED DATABASE FOR DIGITAL BRAIN IMAGES
    Edward H Herskovits; Fiscal Year: 2010
    ..First, our current data-mining approaches are designed to generate Bayesian networks that model a structure-function relationship;that is, these ..
  76. Droplet Compartmentalized Selection for Deep-Mining of Antibody Diversity
    JOHN HEYMAN; Fiscal Year: 2009
    ..Moreover, because the antibodies from a single cell can be detected, it becomes possible to directly screen non-immortalized cells instead of hybridomas, further increasing the antibody diversity that can be accessed. ..
  77. Using Electronic Data to Improve Care of Patients with Known or Suspected Cancer
    Hardeep Singh; Fiscal Year: 2010
    ..We will build upon our previous and ongoing work in innovative data mining techniques to identify patients likely to have delays in cancer diagnosis or treatment, and we will facilitate ..
  78. Multi-Hazard Sensor for Miners
    MICHAEL FRISH; Fiscal Year: 2006
    ..The mining industry presents particularly challenging safety and health needs...
  79. TGFB AND GENE THERAPY IN SILICA INDUCED LUNG FIBROSIS
    Patricia Sime; Fiscal Year: 2005
    Inhalation of silica in mining, sandblasting and quarrying occupations results in serious, potentially life threatening, pulmonary inflammatory and fibrotic pathologies including acute and chronic (nodular pulmonary fibrosis) silicosis...
  80. Phase II: Advanced Personal Gas Detectors for Mining Applications
    DMITRI ROUTKEVITCH; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The mining industry is one of the more challenging occupational sectors that involve adverse workers conditions, including ..
  81. POSTURAL STABILITY EFFECTS IN LOW SEAM MINING TASKS
    Amit Bhattacharya; Fiscal Year: 2001
    ..These findings will provide the framework within which future mining worker- population-based prospective studies can be designed to address the following issues...