Top Publications

  1. ncbi Does the architecture of hospital facilities influence nosocomial infection rates? A systematic review
    M Dettenkofer
    Institute of Environmental Medicine and Hospital Epidemiology, University Hospital of Freiburg, Freiburg, Germany
    Infect Control Hosp Epidemiol 25:21-5. 2004
  2. ncbi New dimensions for future health care facilities
    Romano Del Nord
    University of Florence, Italy
    World Hosp Health Serv 43:23-6. 2007
  3. ncbi The patient room
    Dagmara Scalise
    Hosp Health Netw 78:34-8, 40, 49-51. 2004
  4. ncbi Guidelines and health care buildings
    Fani Vavili
    School of Architecture, Faculty of Technology, Aristotle University of Thessaloniki, Greece
    World Hosp Health Serv 39:24-5, 28-31, 42 pasim. 2003
  5. ncbi Designing for "the little convalescents": children's hospitals in Toronto and Montreal, 1875-2006
    Annmarie Adams
    School of Architecture, McGill University
    Can Bull Med Hist 19:201-43. 2002
  6. ncbi [Directions in hospital assistance in Rio de Janeiro (1923-31)]
    Gisele Sanglard
    Hist Cienc Saude Manguinhos 11:107-42. 2004
  7. ncbi The role of the architectural environment in community health: an evidence-based initiative
    Stephen Verderber
    School of Architecture, Department of Health Systems Management, Tulane University, New Orleans, Louisiana 70118, USA
    J Public Health Manag Pract 11:79-89. 2005
  8. ncbi Medical facilities as moral worlds
    L Turner
    Biomedical Ethics Unit and Department of Social Studies and Medicine, McGill University, McGill University, Montreal, Quebec, Canada
    Med Humanit 28:19-22. 2002
  9. pmc Henry Currey FRIBA (1820-1900): leading Victorian hospital architect, and early exponent of the "pavilion principle"
    G C Cook
    Wellcome Trust Centre for the History of Medicine at UCL, 183 Euston Road, London, NW1 2BE, UK
    Postgrad Med J 78:352-9. 2002
  10. ncbi Architectural design of a secure forensic state psychiatric hospital
    Joel A Dvoskin
    University of Arizona College of Medicine, 5174 N Via de la Lanza, Tucson, AZ 85750 7077, USA
    Behav Sci Law 20:481-93. 2002

Detail Information

Publications263 found, 100 shown here

  1. ncbi Does the architecture of hospital facilities influence nosocomial infection rates? A systematic review
    M Dettenkofer
    Institute of Environmental Medicine and Hospital Epidemiology, University Hospital of Freiburg, Freiburg, Germany
    Infect Control Hosp Epidemiol 25:21-5. 2004
    ..To review the evidence regarding the effects of interventions to improve hospital design and construction on the occurrence of nosocomial infections...
  2. ncbi New dimensions for future health care facilities
    Romano Del Nord
    University of Florence, Italy
    World Hosp Health Serv 43:23-6. 2007
  3. ncbi The patient room
    Dagmara Scalise
    Hosp Health Netw 78:34-8, 40, 49-51. 2004
  4. ncbi Guidelines and health care buildings
    Fani Vavili
    School of Architecture, Faculty of Technology, Aristotle University of Thessaloniki, Greece
    World Hosp Health Serv 39:24-5, 28-31, 42 pasim. 2003
  5. ncbi Designing for "the little convalescents": children's hospitals in Toronto and Montreal, 1875-2006
    Annmarie Adams
    School of Architecture, McGill University
    Can Bull Med Hist 19:201-43. 2002
    This paper explores more than a century of changing ideas about the health of Canadian children through the architecture of pediatric hospitals in Montreal and Toronto...
  6. ncbi [Directions in hospital assistance in Rio de Janeiro (1923-31)]
    Gisele Sanglard
    Hist Cienc Saude Manguinhos 11:107-42. 2004
    ..taking place at a critical moment, when there was a shortage of hospital beds throughout Rio, at the same time that adoption of the traditional pavilion structure was hindered by the advances introduced by modern architecture in block.
  7. ncbi The role of the architectural environment in community health: an evidence-based initiative
    Stephen Verderber
    School of Architecture, Department of Health Systems Management, Tulane University, New Orleans, Louisiana 70118, USA
    J Public Health Manag Pract 11:79-89. 2005
    ..The SFI process is discussed as an evidence-based means to foster greater systemic success in capital improvement efforts within public sector health agencies in the United States and in international contexts...
  8. ncbi Medical facilities as moral worlds
    L Turner
    Biomedical Ethics Unit and Department of Social Studies and Medicine, McGill University, McGill University, Montreal, Quebec, Canada
    Med Humanit 28:19-22. 2002
    ..To discuss the ethos of place is to focus on the character or atmosphere of particular dwellings. Architecture, interior design, and the interior creation of built environments have moral, spiritual, and aesthetic ..
  9. pmc Henry Currey FRIBA (1820-1900): leading Victorian hospital architect, and early exponent of the "pavilion principle"
    G C Cook
    Wellcome Trust Centre for the History of Medicine at UCL, 183 Euston Road, London, NW1 2BE, UK
    Postgrad Med J 78:352-9. 2002
    ..One of the leading exponents of this style of hospital architecture was Henry Currey (1820-1900) whose greatest achievement was undoubtedly the design for the new St Thomas's ..
  10. ncbi Architectural design of a secure forensic state psychiatric hospital
    Joel A Dvoskin
    University of Arizona College of Medicine, 5174 N Via de la Lanza, Tucson, AZ 85750 7077, USA
    Behav Sci Law 20:481-93. 2002
    ..The heart of the facility is a large treatment mall, designed to foster the acquisition of social, emotional, cognitive, and behavioral skills that will help patients to safely return to their communities...
  11. ncbi Tradition and modernity in upgrading the new "Meyer" Children Hospital in Florence
    Romano Del Nord
    University of Florence
    World Hosp Health Serv 39:23-6, 32-3. 2003
    ..The presence of a monumental garden area, all around the building, has been used as a generator-input of the functional organization and, in this sense, has resulted particularly successful for the Public Client Organization...
  12. ncbi Anatomy meets architecture: designing new laboratories for new anatomists
    Robert B Trelease
    Division of Integrative Anatomy, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, CA 90095, USA
    Anat Rec B New Anat 289:241-51. 2006
    General notions of architecture are familiar to anatomists, and they frequently use the word in describing the functional structures of cells, tissues, and whole organisms...
  13. pmc Experience-based design: from redesigning the system around the patient to co-designing services with the patient
    Paul Bate
    Centre for Health Informatics and Multiprofessional Education, Royal Free and University College Medical School, University College London, London, UK
    Qual Saf Health Care 15:307-10. 2006
  14. ncbi Neuroscience and architecture: seeking common ground
    Esther M Sternberg
    Integrative Neural Immune Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 127:239-42. 2006
  15. ncbi Architectural design and the collaborative research environment
    Roger N Goldstein
    Goody Clancy, Boston, MA 02116, USA
    Cell 127:243-6. 2006
    ..Given that science is a collaborative endeavor, architects are striving to design new research buildings that not only provide a more pleasant work space but also facilitate interactions among researchers...
  16. ncbi [Standardised environmental conditions for neurocognitive laboratories]
    M Matamoros-Tuma
    Departamento de Diseño Instituto Superior Politécnico José Antonio Echevarría Facultad de Arquitectura, Marianao, Cuba
    Rev Neurol 35:895-9. 2002
    ..This gives rise to two types of drawbacks: interferences in the patient s concentration and low reproducibility of the results in other laboratories...
  17. ncbi Why the future of architecture doesn't need us
    Lance Hosey
    William McDonough and Partners
    World Hosp Health Serv 38:31-3, 42, 44. 2002
    ..Traditional standards of architectural theory may become altogether irrelevant...
  18. ncbi Acoustic analysis in Mudejar-Gothic churches: experimental results
    Miguel Galindo
    Departamento de Fisica Aplicada II, Universidad de Sevilla, ETS de Arquitectura, Avda Reina Mercedes 2, 41012 Sevilla, Spain
    J Acoust Soc Am 117:2873-88. 2005
    ..Analysis of the quality of the spaces for music and speech is carried out according to the most widespread criteria for auditoria...
  19. ncbi Risky business. Organizations tackle infection control during construction
    Beth Burmhal
    Hosp Health Netw 77:78-82, 2. 2003
    ..Guidelines from three prominent organizations are finally helping hospitals understand how to prevent infections during those projects...
  20. ncbi [A study of the architectural factors and the infection rates of healthcare workers in isolation units for severe acute respiratory syndrome]
    Shan Ping Jiang
    Department of Medicine, The Second Affiliated Hospital, Sun Yat Sen University, Guangzhou 510120, China
    Zhonghua Jie He He Hu Xi Za Zhi 26:594-7. 2003
    ..To investigate measures to prevent the outbreak of severe acute respiratory syndrome (SARS) in healthcare workers in isolation units...
  21. ncbi New development of the University of Tokyo teaching hospital
    Yasushi Nagasawa
    University of Tokyo, Department of Architecture
    World Hosp Health Serv 38:34-9. 2002
  22. ncbi Pumped up prices? Advice on controlling scope creep in health care construction projects
    J Kenneth Upchurch
    Centre for Health Care Planning, Nashville, Tenn, USA
    Health Facil Manage 16:26-31. 2003
    ..While some are justified by factors that influence space requirements, such as changing market needs, new physicians or new technology, others inflate the cost of a construction project without adding significant benefits...
  23. ncbi [The hospital: architecture and technology]
    Roberto Palumbo
    Facoltà di Architettura Valle Giulia, Universita di Roma La Sapienza, I
    Med Secoli 14:243-58. 2002
    ..with the "morphological quality" of the hospital, so that it seems necessary to re-think its specific architecture according to the urban context, to requested better life conditions, to the humanizing process in which medical ..
  24. ncbi On the value of architecture and facility management in health administration education
    Stephen F Verderber
    School of Architecture, Tulane University, New Orleans, LA 70118, USA
    J Health Adm Educ 20:39-60. 2002
    This article discusses the role and function of architecture and facility management in health administration education vis-à-vis an interdisciplinary set of courses taught in a graduate-level health administration program...
  25. ncbi "Things that went well--no serious injuries or deaths": ethical reasoning in a normal engineering design process
    Peter Lloyd
    School of Industrial Design Engineering, TU Delft, Landbergstraat 15, 2628 CE Delft, The Netherlands
    Sci Eng Ethics 9:503-16. 2003
  26. ncbi Architecture and power: a family planning clinic as a case study
    Rosemary Gillespie
    School of Social and Historical Studies, University of Portsmouth, Hampshire PO1 3AS, UK
    Health Place 8:211-20. 2002
    This paper considers the interface between architecture and sociology...
  27. ncbi Architectural programming for the workplace and the careplace
    James G Easter
    Easter and Mason Healthcare Consulting, Nashville, TN, USA
    J Oncol Manag 11:18-23. 2002
    ..With this experienced team on board; following the proper steps, listening carefully to the answers and observing the daily process one can expect a successful product...
  28. ncbi Setting the space for sex: architecture, desire and health issues in gay bathhouses
    Dave Holmes
    Faculty of Health Sciences, School of Nursing, University of Ottawa, 451 Smyth Road, Ottawa, Ont, Canada K1H 8M5
    Int J Nurs Stud 44:273-84. 2007
  29. ncbi College students' perceptions of sexual orientation and gender given job descriptions and titles for interior decoration, interior design, and architecture
    B Jeanneane Wood-Nartker
    B Jeanneane Wood Nartker, Central Michigan University, Wightman 205, Mount Pleasant, MI 48859, USA
    Percept Mot Skills 104:1025-6. 2007
    ..Furthermore, the results also indicated that if the design professional was perceived to be male, there was a higher tendency that he would be perceived as homosexual, especially by a male respondent...
  30. ncbi Task demands and human capabilities in door use
    Shih Kai Chang
    Department of Industrial Engineering, University at Buffalo, Buffalo, NY 14260, USA
    Appl Ergon 38:325-35. 2007
    ..These results suggests that those specifying doors for building s use a restoring torque below 30 Nm and site the handle or push plate 250-350 mm from the door edge and 1000-1500 mm above the floor...
  31. ncbi [Tuberculosis and the modern ideal of living]
    T C Medici
    Universitat Zurich
    Praxis (Bern 1994) 92:1382-91. 2003
    ..The modern movement with all its facets including modern architecture is barely conceivable without it...
  32. ncbi Conservative restoration of the Augustus Arch of Fano: cleaning methodology as derived from preparatory analyses and sampling
    Luca Boiardi
    Dipartimento di Architettura e Pianificazione Territoriale, Universita di Bologna, Viale Risorgimento 2, 40136 Bologna, Italy
    Ann Chim 93:919-26. 2003
    ..Every intervention on such an important monument need to obtain at the same time the best result for materials conservation and the aim of image restore...
  33. ncbi The restoration of the Sangallo bastion in Fano: researches, surveyings, and conservation techniques
    Claudio Galli
    Dipartimento di Architettura e Pianificazione Territoriale, Universita di Bologna, Viale Risorgimento 2, 40136 Bologna, Italy
    Ann Chim 93:927-34. 2003
  34. ncbi [The Rome Policlinico Umberto I: an innovative project]
    Carla Serarcangeli
    Museo di Storia della Medicina, Dipartimento di Medicina Sperimentale e Patologia Universita degli Studi di Roma La Sapienza, Roma, I
    Med Secoli 14:155-75. 2002
    ..Guido Baccelli was the promoter of the project: his political and scientific commitment are proved by the imposing architectural structure and by the economic effort that were needed to build the Policlinico...
  35. ncbi Reasons for applying innovations for scaffolding work
    Annelise M de Jong
    Faculty of Industrial Design, Delft University of Technology, Delft, The Netherlands
    Int J Occup Saf Ergon 9:161-75. 2003
    ..The reason for not applying the innovations concerned specific situations, such as offshore work, in which innovations were not applicable...
  36. ncbi Monitoring the colonization of monuments by bacteria: cultivation versus molecular methods
    Leonila Laiz
    Instituto de Recursos Naturales y Agrobiologia, CSIC, Apartado 1052, Avenida Reina Mercedes, 10, 41012 Sevilla, Spain
    Environ Microbiol 5:72-4. 2003
    ..The data suggest that plating leads to an overestimation of the number of spore-forming bacteria with respect to quiescent vegetative forms; the latter are less easily cultured, but are readily detected by culture-independent techniques...
  37. pmc Building camps and work related injuries
    F Tuchsen
    National Institute of Occupational Health, Copenhagen, Denmark
    Occup Environ Med 61:370-1. 2004
    ..To focus on one possible predictor of reported work related injuries--the role of living in building-site camps versus daily commuting from home to construction sites...
  38. ncbi Ceiling baffles and reflectors for controlling lecture-room sound for speech intelligibility
    Wonyoung Yang
    Acoustics and Noise Research Group, School of Occupational and Environmental Hygiene, University of British Columbia, 2206 East Mall, Vancouver, BC, Canada V6T 1Z3
    J Acoust Soc Am 121:3517-26. 2007
    ..8 m long and randomly distributed, with flat side up or down, and reflective or absorptive top surfaces. The long reflectors with flat side down and no absorption were somewhat effective; the other configurations were not...
  39. ncbi Forensic analysis of architectural finishes using fourier transform infrared and Raman spectroscopy, part II: white paint
    Steven E J Bell
    School of Chemistry, Queen s University, Belfast, BT9 5AG, U K
    Appl Spectrosc 59:1340-6. 2005
    ..The combination of increased discrimination and higher sample throughput means that the Raman method is superior to FT-IR for samples of this type...
  40. ncbi Forensic analysis of architectural finishes using fourier transform infrared and Raman spectroscopy, part I: the resin bases
    Steven E J Bell
    School of Chemistry, Queen s University, Belfast, BT9 5AG, U K
    Appl Spectrosc 59:1333-9. 2005
  41. ncbi Temperament profiles in physicians, lawyers, managers, industrialists, architects, journalists, and artists: a study in psychiatric outpatients
    Kareen K Akiskal
    International Mood Center, San Diego USA and French Depressive and Manic Depressive Association, Rennes, France
    J Affect Disord 85:201-6. 2005
    ..With the possible exception of cyclothymia in artists, there is a paucity of data in the literature on the temperament in different professions...
  42. ncbi Possible association of body dysmorphic disorder with an occupation or education in art and design
    David Veale
    Department of Psychiatry and Behavioural Sciences, Royal Free Campus, Royal Free and University College School of Medicine, University of London, London, England, UK
    Am J Psychiatry 159:1788-90. 2002
  43. ncbi Dr William Thornton (1759-1828) a savant of colonial America
    Norman G Schneeberg
    J Med Biogr 14:163-8. 2006
    ..He is not well known to medical historians and 21st century physicians and is remembered principally as the amateur architect who designed the Capitol in Washington, DC and the Library Company of Philadelphia...
  44. ncbi Concerns about infectious hepatitis and Delacorte's Welfare Island Fountain
    Allen D Spiegel
    State University of New York, Downstate Medical Center, College of Medicine, Brooklyn, New York 11203, USA
    J Community Health 29:245-64. 2004
    ..quot; Eventually, Delacorte gave up. In the late 1980s, the fountain ceased spouting and was finally dismantled...
  45. ncbi Blurring the boundaries of space: shaping nursing lives at the Red Cross outposts in Ontario, 1922-1945
    Jayne Elliott
    Department of History at Queen s University, Kingston
    Can Bull Med Hist 21:303-25. 2004
    Historians and other scholars interested in the history of hospitals have investigated the links between medical architecture and the organization of space with the evolution of modern medicine...
  46. ncbi The application of the biosphere reserve concept to urban areas: the case of green rooftops for habitat network in Seoul
    Kwi Gon Kim
    Department of Landscape Architecture, Seoul National University, Seoul 151 742, Korea
    Ann N Y Acad Sci 1023:187-214. 2004
    ..Based on the Seoul example, as well as urban biosphere reserve models suggested by the MAB Urban Group, we suggest several principles to be applied for a green rooftops to qualify as a category of urban biosphere reserves...
  47. ncbi The weathering of natural and artificial stones in the baroque church of S. Pietro in Valle (Fano-Italy)
    Michela Maione
    Universita degli Studi di Urbino, Istituto di Scienze Chimiche, Piazza Rinascimento 6, 61029 Urbino, Italy
    Ann Chim 93:415-20. 2003
  48. ncbi Acoustic energy relations in Mudejar-Gothic churches
    Teófilo Zamarreño
    Departamento de Fisica Aplicada II, Universidad de Sevilla, ETS de Arquitectura IUCC, Avda Reina Mercedes 2, 41012 Sevilla, Spain
    J Acoust Soc Am 121:234-50. 2007
  49. ncbi Evaluation of stage acoustics in Seoul Arts Center Concert Hall by measuring stage support
    Jin Yong Jeon
    School of Architectural Engineering, Hanyang University, Seoul 133 791, Korea
    J Acoust Soc Am 117:232-9. 2005
    ..Conclusions are drawn both relating to the Seoul Concert Hall stage and stages in general...
  50. ncbi Chronological analysis of architectural and acoustical indices in music performance halls
    Youngmin Kwon
    Architecture Technology Research Center School of Architecture, University of Florida, 231 ARCH, P O Box 115702, Gainesville, Florida 32611, USA
    J Acoust Soc Am 121:2691-9. 2007
    ..Some indices appear correlated with each other...
  51. pmc Clinical neurosciences in the decade of the brain: hypotheses in neuro-oncology. VEG/PF acts upon the actin cytoskeleton and is inhibited by dexamethasone: relevance to tumor angiogenesis and vasogenic edema
    G R Criscuolo
    Yale University Medical Center, New Haven, Connecticut, USA
    Yale J Biol Med 69:337-55. 1996
    HYPOTHESIS: We have proposed that VEG/PF acts by transforming the cytoskeletal architecture of microvascular endothelial cells...
  52. ncbi Angiogenic histogenesis of stromal cells in hemangioblastoma: ultrastructural and immunohistochemical study
    B Lach
    Department of Laboratory Medicine and Pathology, University of Ottawa, Canada
    Ultrastruct Pathol 23:299-310. 1999
    ..of SC in hemangioblastoma could be related to a limited ability of angioformative stromal cells to develop an architecture of capillary lumina integrated with the vascular network of the tumor...
  53. ncbi Differences in sleep variables, blood adenosine, and body temperature between hypothyroid and euthyroid rats before and after REM sleep deprivation
    R J Salin-Pascual
    , Facultad de Medicina, , Mexico
    Sleep 20:957-62. 1997
    ..rats by surgical removal of thyroid glands without extirpation of the parathyroid; 2) to observe the sleep architecture in euthyroid (Etx) and hypothyroid (Htx) rats, both before and after rapid eye movement (REM) sleep deprivation ..
  54. ncbi Experimental infection of cattle with Trypanosoma brucei rhodesiense
    B T Wellde
    Walter Reed Project, Veterinary Research Laboratory, Ministry of Agriculture and Livestock Development, Kabete, Kenya
    Ann Trop Med Parasitol 83:133-50. 1989
    ..consisted of large numbers of astrocytes, rarefaction of the parenchyma, and areas of necrosis with loss of normal architecture. Demyelination was limited to perivascular areas. Occasionally a moderate to severe pancarditis was found.
  55. ncbi The functions of laminins: lessons from in vivo studies
    M C Ryan
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Matrix Biol 15:369-81. 1996
    ..The ultrastructure of the epithelium appears normal, as does the architecture of the papillary dermis. Only the anchoring complex itself is aberrant...
  56. ncbi Compression-induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element study
    J C Lotz
    Department of Orthopaedic Surgery, University of California, San Francisco, California, USA
    Spine (Phila Pa 1976) 23:2493-506. 1998
    ..Discs loaded at the lowest stress recovered anular architecture but not cellularity after 1 month of recuperation...
  57. pmc The genesis of peritumoral vasogenic brain edema and tumor cysts: a hypothetical role for tumor-derived vascular permeability factor
    G R Criscuolo
    Brain Edema Research Laboratory, Yale University School of Medicine Street, New Haven, Connecticut 06510
    Yale J Biol Med 66:277-314. 1993
    ..Departure from the typical blood-brain barrier microvascular architecture may only partially explain the occurrence of edema and tumor cyst formation...
  58. pmc The architecture of the connective tissue in the musculoskeletal system-an often overlooked functional parameter as to proprioception in the locomotor apparatus
    Jaap van der Wal
    University Maastricht, Faculty of Health, Medicine and Life Sciences, Department of Anatomy and Embryology, Maastricht, Netherlands
    Int J Ther Massage Bodywork 2:9-23. 2009
    The architecture of the connective tissue, including structures such as fasciae, sheaths, and membranes, is more important for understanding functional meaning than is more traditional anatomy, whose anatomical dissection method neglects ..
  59. ncbi Retinal vascular architecture is maintained in retinal degeneration: corrosion cast and electron microscope study
    I A Bhutto
    Department of Ophthalmology, Nagasaki University School of Medicine, Japan
    Eye (Lond) 15:531-8. 2001
    To demonstrate the changes of the retinal vascular architecture in the diffusely degenerated thin retina.
  60. pmc The complete chloroplast DNA sequence of the green alga Oltmannsiellopsis viridis reveals a distinctive quadripartite architecture in the chloroplast genome of early diverging ulvophytes
    Jean Francois Pombert
    Departement de Biochimie et de Microbiologie, Universite Laval, Quebec, Canada
    BMC Biol 4:3. 2006
    ..genome of Pseudendoclonium (Ulvophyceae), in particular, is characterized by an atypical quadripartite architecture that deviates from the ancestral type by a large inverted repeat (IR) featuring an inverted rRNA operon and a ..
  61. ncbi Human brain evolution and the "Neuroevolutionary Time-depth Principle:" Implications for the Reclassification of fear-circuitry-related traits in DSM-V and for studying resilience to warzone-related posttraumatic stress disorder
    H Stefan Bracha
    Department of Veterans Affairs, Pacific Islands Health Care System, and Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A Burns School of Medicine, University of Hawaii, Honolulu 96813 2830, USA
    Prog Neuropsychopharmacol Biol Psychiatry 30:827-53. 2006
    ..Genetic architecture-charting of fear-circuitry-related traits has been challenging...
  62. ncbi Astroglial architecture of the carp (Cyprinus carpio) brain as revealed by immunohistochemical staining against glial fibrillary acidic protein (GFAP)
    M Kalman
    Department of Anatomy, Histology and Embryology, Semmelweis University of Medicine, Budapest, Hungary
    Anat Embryol (Berl) 198:409-33. 1998
    ..g., the telencephalon. The results show that the teleost brain has a varied and highly specialized astroglial architecture. The primary system is made up of radial glia, which are of ependymal origin and cover the pial surface with ..
  63. ncbi Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death
    D T Finegood
    Diabetes Research Laboratory, School of Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada
    Diabetes 50:1021-9. 2001
    ..leptin receptor-deficient (fa/fa) Zucker diabetic fatty (ZDF) rat is associated with disruption of normal islet architecture, beta-cell degranulation, and increased beta-cell death...
  64. ncbi [Changes in bone micro-architecture and bone mineral density following experimental osteonecrosis of femoral head by local injection of ethanol in canines]
    Hongshuai Li
    Department of Orthopaedics, 6th People s Hospital Affiliated to Shanghai Jiaotong University, Shanghai, 200233, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 22:281-9. 2008
    To measure the changes of bone mineral density and bone micro-architecture of the femoral head that harvested from the three-foot bearing ethanol destroyed canine model for osteonecrosis of femoral head, and discuss the influences of ..
  65. ncbi The geometric architecture of the subtalar and midtarsal joints in rheumatoid arthritis based on magnetic resonance imaging
    James Woodburn
    Rheumatology and Rehabilitation Research Unit, University of Leeds, Leeds, UK
    Arthritis Rheum 46:3168-77. 2002
    To compare in vivo the 3-dimensional (3-D) geometric architecture of the subtalar and midtarsal joints in normal and rheumatoid arthritic (RA) feet, using magnetic resonance imaging (MRI) analysis.
  66. ncbi The structural architecture of adult mammalian articular cartilage evolves by a synchronized process of tissue resorption and neoformation during postnatal development
    E B Hunziker
    University of Bern, ITI Research Institute for Dental and Skeletal Biology, Murtenstrasse 35, PO Box 54, Bern, Switzerland
    Osteoarthritis Cartilage 15:403-13. 2007
    ..a fundamental process of structural reorganization from an immature isotropic to a mature (adult) anisotropic architecture. However, the mechanism underlying this structural transformation is unknown...
  67. ncbi Sleep architecture in term and preterm infants beyond the neonatal period: the influence of gestational age, steroids, and ventilatory support
    Toke Hoppenbrouwers
    Department of Pediatrics, Division of Neonatology and Neonatal Medicine, University of Southern California, Keck School of Medicine, Los Angeles, USA
    Sleep 28:1428-36. 2005
    To examine (1) sleep architecture of infants at varied risk for sudden infant death syndrome, (2) delays or advances in preterm infants at term postmenstrual age, (3) whether ventilatory support and gestational age alter sleep, (4) ..
  68. ncbi Hydraulic architecture and photosynthetic capacity as constraints on release from suppression in Douglas-fir and western hemlock
    Heidi J Renninger
    Department of Wood Science and Engineering, Oregon State University, 119 Richardson Hall, Corvallis, OR 97331, USA
    Tree Physiol 27:33-42. 2007
    We compared hydraulic architecture, photosynthesis and growth in Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco), a shade-intolerant species, and western hemlock (Tsuga heterophylla (Raf.) Sarg...
  69. pmc Chloroplast DNA sequence of the green alga Oedogonium cardiacum (Chlorophyceae): unique genome architecture, derived characters shared with the Chaetophorales and novel genes acquired through horizontal transfer
    Jean Simon Brouard
    Departement de Biochimie et de Microbiologie, Universite Laval, Quebec, QC G1V 0A6, Canada
    BMC Genomics 9:290. 2008
    ..Scenedesmus (Sphaeropleales), and Stigeoclonium (Chaetophorales) revealed tremendous variability in their architecture, the retention of only few ancestral gene clusters, and derived clusters shared by Chlamydomonas and ..
  70. pmc A role for auxin redistribution in the responses of the root system architecture to phosphate starvation in Arabidopsis
    Philippe Nacry
    Laboratoire de Biochimie and Physiologie Moléculaire des Plantes, Unité Mixte de Recherche 5004, Institut National de la Recherche Agronomique, Universite Montpellier 2, F 34060 Montpellier Cedex 1, France
    Plant Physiol 138:2061-74. 2005
    The changes in root system architecture (RSA) triggered by phosphate (P) deprivation were studied in Arabidopsis (Arabidopsis thaliana) plants grown for 14 d on 1 mM or 3 microM P...
  71. ncbi Benzodiazepines in congestive heart failure: effects of temazepam on arousability and Cheyne-Stokes respiration
    D J Biberdorf
    Department of Respiratory Medicine, University of Manitoba, Winnipeg, Canada
    Sleep 16:529-38. 1993
    ..SD] in a double-blind crossover trial to determine the effects of temazepam 15 mg on arousability, sleep architecture, Cheyne-Stokes respiration (CSR) and nighttime oxygen saturation...
  72. ncbi Comparison of cross-sectional geometry of the proximal femur in white and black women from Detroit and Johannesburg
    Dorothy A Nelson
    Department of Internal Medicine, Wayne State University, Detroit, Michigan 48201, USA
    J Bone Miner Res 19:560-5. 2004
    There are known black-white differences in bone density measured by DXA but less is known about bone architecture. We compared cross-sectional geometric properties of the proximal femur in U.S...
  73. pmc In vivo magnetic resonance detects rapid remodeling changes in the topology of the trabecular bone network after menopause and the protective effect of estradiol
    Felix W Wehrli
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Bone Miner Res 23:730-40. 2008
  74. ncbi Design and function of molecular and bioelectronics devices
    Predrag Krstic
    Oak Ridge National Laboratory
    Nanotechnology 18:420201. 2007
    ..symposium Nano and Giga Challenges in Electronics and Photonics: From Atoms to Materials to Devices to System Architecture (12-16 March, 2007, Phoenix, Arizona, USA), as well as from original and novel scientific contributions of ..
  75. ncbi Comparative analysis of masseter fiber architecture in tree-gouging (Callithrix jacchus) and nongouging (Saguinus oedipus) callitrichids
    Andrea B Taylor
    Department of Community and Family Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Morphol 261:276-85. 2004
    ..We compared the fiber architecture of the masseter muscle in tree-gouging Callithrix jacchus (n = 10) to nongouging Saguinus oedipus (n = 8) to ..
  76. ncbi Site specificity of bone architecture between the distal radius and distal tibia in children and adolescents: An HR-pQCT study
    Danmei Liu
    Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada
    Calcif Tissue Int 87:314-23. 2010
    High-resolution quantitative computerized tomography permits evaluation of site specific differences in bone architecture. The purpose of this study was to compare bone architecture between distal radius and distal tibia...
  77. ncbi Restraint increases prolactin and REM sleep in C57BL/6J mice but not in BALB/cJ mice
    P Meerlo
    Department of Neurobiology and Physiology, Northwestern University, 2153 North Campus Dr, Evanston, IL 60208, USA
    Am J Physiol Regul Integr Comp Physiol 281:R846-54. 2001
    Sleep is generally considered to be a recovery from prior wakefulness. The architecture of sleep not only depends on the duration of wakefulness but also on its quality in terms of specific experiences...
  78. ncbi Effects of salmon calcitonin on trabecular microarchitecture as determined by magnetic resonance imaging: results from the QUEST study
    Charles H Chesnut
    Osteoporosis Research Group, Department of Radiology UWMC ORG, University of Washington Medical Center, Seattle, Washington 98105 4631, USA
    J Bone Miner Res 20:1548-61. 2005
    ..MRI analyses of os calcis or microCT/histomorphometric analyses of bone biopsies did not reveal consistent differences in architecture between CT-NS and placebo.
  79. ncbi Long-term prediction of three-dimensional bone architecture in simulations of pre-, peri- and post-menopausal microstructural bone remodeling
    Ralph Muller
    Institute for Biomedical Engineering, Swiss Federal Institute of Technology ETH and University of Zurich
    Osteoporos Int 16:S25-35. 2005
    ..The aim of this project was to investigate if changes in the trabecular architecture as observed with age-related bone loss and osteoporosis can be predicted from a computer model that simulates ..
  80. pmc Molecular architecture of the fruit fly's airway epithelial immune system
    Christina Wagner
    Forschungszentrum Borstel, Department of Immunology and Cell Biology, Borstel, Germany
    BMC Genomics 9:446. 2008
    ..To elucidate the molecular architecture of the innate immune system of airway epithelial cells, we choose the fruit fly Drosophila melanogaster as a ..
  81. ncbi Trabecular bone architecture in the distal radius using magnetic resonance imaging in subjects with fractures of the proximal femur. Magnetic Resonance Science Center and Osteoporosis and Arthritis Research Group
    S Majumdar
    Department of Radiology, and Department of Internal Medicine, University of California, San Francisco, California, USA
    Osteoporos Int 10:231-9. 1999
    To determine whether magnetic resonance (MR)-derived measures of trabecular bone architecture in the distal radius are predictive for prevalent hip fractures, 20 subjects with hip fractures and 19 age-matched postmenopausal controls were ..
  82. ncbi Zoledronic acid treatment results in retention of femoral head structure after traumatic osteonecrosis in young Wistar rats
    David G Little
    Orthopaedic Research Unit, The Children s Hospital at Westmead, Westmead, New South Wales, Sydney, Australia
    J Bone Miner Res 18:2016-22. 2003
    Osteonecrosis (ON) of the femoral head in childhood can lead to loss of femoral head architecture and subsequent deformity...
  83. ncbi Both hPTH(1-34) and bFGF increase trabecular bone mass in osteopenic rats but they have different effects on trabecular bone architecture
    Nancy E Lane
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143, USA
    J Bone Miner Res 18:2105-15. 2003
    ..The purpose of this study was to compare how trabecular bone architecture, bone cell activity, and strength are altered by two different bone anabolic agents, bFGF and hPTH(1-34), in an ..
  84. ncbi The evolution of genetic architecture. I. Diversification of genetic backgrounds by genetic drift
    Reinaldo A De Brito
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Evolution 59:2333-42. 2005
    The genetic architecture of a phenotype plays a critical role in determining phenotypic evolution through its effects on patterns of genetic variation...
  85. ncbi Inappropriate P-cadherin expression in the mouse mammary epithelium is compatible with normal mammary gland function
    Glenn L Radice
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Differentiation 71:361-73. 2003
    Cadherins comprise a family of cell-cell adhesion proteins critical to the architecture and function of tissues...
  86. pmc A preliminary analysis of the relationship between jaw-muscle architecture and jaw-muscle electromyography during chewing across primates
    Christopher J Vinyard
    Department of Anatomy and Neurobiology, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA
    Anat Rec (Hoboken) 293:572-82. 2010
    ..Recent work on primate jaw-muscle architecture demonstrates significant associations with dietary variation and feeding behaviors...
  87. pmc Jaw-muscle fiber architecture in tufted capuchins favors generating relatively large muscle forces without compromising jaw gape
    Andrea B Taylor
    Doctor of Physical Therapy Division, Department of Community and Family Medicine, Duke University School of Medicine, Box 104002, Durham, NC 27708, USA
    J Hum Evol 57:710-20. 2009
    ..We compared fiber architecture of the masseter and temporalis muscles between C. apella (n=12) and two "untufted" capuchins (C...
  88. ncbi Assembly of transverse tubule architecture in the middle and myotendinous junctional regions in developing rat skeletal muscle fibers
    Susumu Yamashita
    Department of Physiological Sciences, National Institute of Fitness and Sports, 1, Shiromizu, Kanoya 891 2393 Kagoshima, Japan
    J Muscle Res Cell Motil 28:141-51. 2007
    ..the myotendinous junction (MTJ) during development, no specific model exists for the assembly of new t-tubule architecture at the MTJ...
  89. pmc Wellbeing of professionals at entry into the labour market: a follow up survey of medicine and architecture students
    P Virtanen
    Medical School, 33014 University of Tampere, Finland
    J Epidemiol Community Health 55:831-5. 2001
    ..Knowledge about changes in wellbeing during the passage from professional studies to working life is scarce and controversial. This study examined these changes among university graduates with good and poor employment prospects...
  90. ncbi ATMTN: a telemammography network architecture
    Ehsan O Sheybani
    University of South Florida, Tampa, FL 33620 USA
    IEEE Trans Biomed Eng 49:1438-43. 2002
    ..This research describes asynchronous transfer mode telemammography network (ATMTN) architecture for real-time, online screening, detection and diagnosis of breast cancer...
  91. pmc Age-related changes of nuclear architecture in Caenorhabditis elegans
    Erin Haithcock
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 102:16690-5. 2005
    ..It has been shown that HGPS cells in culture undergo age-dependent progressive changes in nuclear architecture. However, it is unknown whether similar changes in nuclear architecture occur during the normal aging process...
  92. ncbi Micro-compression: a novel technique for the nondestructive assessment of local bone failure
    R Muller
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Technol Health Care 6:433-44. 1998
    ..However, the relative importance of bone density and architecture in the etiology of these fractures is poorly understood...
  93. ncbi Migration of the Japanese healthcare enterprise from a financial to integrated management: strategy and architecture
    M Akiyama
    Department of Medical Informatics, International Medical Center of Japan, Tokyo, 162 8655, Japan
    Stud Health Technol Inform 84:715-8. 2001
    The Hospital Information System (HIS) has been positioned as the hub of the healthcare information management architecture. In Japan, the billing system assigns an "insurance disease names" to performed exams based on the diagnosis type...
  94. pmc Plastic architecture of bacterial genome revealed by comparative genomics of Photorhabdus variants
    Sophie Gaudriault
    INRA, UMR 1133, Laboratoire EMIP, Place Eugene Bataillon, F 34095 Montpellier, France
    Genome Biol 9:R117. 2008
    The phenotypic consequences of large genomic architecture modifications within a clonal bacterial population are rarely evaluated because of the difficulties associated with using molecular approaches in a mixed population...
  95. ncbi High-grade prostatic intraepithelial neoplasialike ductal adenocarcinoma of the prostate: a clinicopathologic study of 28 cases
    Fabio Tavora
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 32:1060-7. 2008
    Most of the prostatic ductal adenocarcinomas of the prostate are characterized by cribriform and/or papillary architecture lined by columnar pseudostratified malignant epithelium...
  96. ncbi Control of metal ion size-based selectivity through chelate ring geometry. metal ion complexing properties of 2,2'-biimidazole
    David Buist
    Department of Chemistry and Biochemistry, University of North Carolina at Wilmington, Wilmington, North Carolina 28403, USA
    Inorg Chem 49:5033-9. 2010
    ..51 A. This metal ion size-based preference of BIM suggests that ligands with such architecture could be used to produce selectivity (differences in log K(1)) for very large metal ions...
  97. ncbi Medical nanorobot architecture based on nanobioelectronics
    Adriano Cavalcanti
    CAN Center for Automation in Nanobiotech, Herminio Lemos 449, Sao Paulo, SP 01540 Brazil
    Recent Pat Nanotechnol 1:1-10. 2007
    This work describes an innovative medical nanorobot architecture based on important discoveries in nanotechnology, integrated circuit patents, and some publications, directly or indirectly related to one of the most challenging new fields ..
  98. ncbi Cerebrospinal hypocretin, daytime sleepiness and sleep architecture in Parkinson's disease dementia
    Yaroslau Compta
    Movement Disorders Unit, ICN, IDIBAPS, CIBERNED, Hospital Clinic, C Villarroel 170, 08036, Barcelona, Spain
    Brain 132:3308-17. 2009 dementia and clinical excessive daytime sleepiness, as well as to describe potentially related sleep architecture changes...
  99. ncbi Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats
    Patrick Ammann
    Service of Bone Diseases, World Health Organization Collaborating Center for Osteoporosis Prevention, Geneva 14 CH 1211, Switzerland
    J Bone Miner Res 19:2012-20. 2004
    ..intact rats at doses up to 900 mg/kg/day increases bone resistance, cortical and trabecular bone volume, micro-architecture, bone mass, and total ALP activity, thus indicating a bone-forming activity and an improvement of overall bone ..
  100. ncbi Interrelationships between bone microarchitecture and strength in ovariectomized monkeys treated with teriparatide
    Peiqi Chen
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Bone Miner Res 22:841-8. 2007
    ..measured at the iliac crest at 6 mo was confirmed to be a reasonable surrogate for, and a predictor of, architecture and strength of the femoral neck and lumbar vertebra after 18 mo of teriparatide treatment...
  101. ncbi Lymph node architecture preceding and following 6 months of potent antiviral therapy: follicular hyperplasia persists in parallel with p24 antigen restoration after involution and CD4 cell depletion in an AIDS patient
    J M Orenstein
    Department of Pathology, George Washington University Medical Center, Washington, DC 20037, USA
    AIDS 13:2219-29. 1999
    To evaluate changes in architecture, viral RNA, and viral protein over 6 months in lymph nodes from retroviral-naïve HIV-infected persons before and after commencing highly active antiretroviral therapy (HAART).

Research Grants72

  1. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  2. Structure and function of urea transporters
    Ming Zhou; Fiscal Year: 2013
    ..However, the current lack of structural information on UTs hampers our understanding of their architecture and function...
  3. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
    ..comprehension of immunological disorders that result from perturbation of signaling pathways and cellular architecture. Public Health Relevance: B cells respond to environmental pathogens such as bacteria and viruses by secreting ..
  4. Regulation of epithelial cell homeostasis by actin microfilaments
    Seema Khurana; Fiscal Year: 2010
    ..Apoptosis plays an important role in determining the architecture of intestinal epithelia and also a part of the stress response of intestinal epithelial cells to toxic stimuli...
  5. Bisphosphonates in the treatment of chronic kidney disease-mineral bone disease
    Sharon M Moe; Fiscal Year: 2013 early and late time points and determine the effect of serum measures of mineral homeostasis, bone turnover, architecture and biomechanics, and arterial calcification, aorta compliance and left ventricular mass index...
  6. Interplay Between Tissue Architecture and Nuclear Organization in the DNA Damage
    Pierre Alexandre Vidi; Fiscal Year: 2013
    ..A great challenge is to understand the DDR in the context of tissues and to define the influence of the tissue architecture (i.e., the organized assembly of multicellular structures) on the DDR...
  7. Targeting AP-1 proteins in COPD
    SEKHAR M POTHIREDDY; Fiscal Year: 2010
    ..proliferation and apoptosis, as well as extracellular matrix degradation, can alter lung cell homeostasis and architecture, leading to the development and progression of COPD...
  8. Nuclear-Cytoplasmic Shuttling of Foxc2 via 14-3-3 Determines Proximal Tubule Cell
    DIANA LYNNE GOLDEN; Fiscal Year: 2012
    ..Tubular regeneration restores normal tubular architecture and renal function following kidney injury...
  9. Mechanisms of Stem Cell Self-Renewal and Aging
    PAUL CHRISTIAN SCHILLER; Fiscal Year: 2013
    ..syndromes caused by accumulation of unprocessed farnesylated nuclear lamina protein lamin-A (key in nuclear architecture), due to alterations in the lamin A gene (LMNA) mRNA splicing, show features of age-related bone loss...
  10. Molecular Biology of Human Erythrocyte Alpha Spectrin
    Patrick G Gallagher; Fiscal Year: 2013 to identify and characterize the cis-sequences, trans-factors, and epigenetic state, including chromatin architecture, across the ?-spectrin gene locus that regulate its expression in erythroid and nonerythroid cells...
  11. Intracellular Serpin Regulation of Intestinal Cell Necrosis
    GARY ARTHUR SILVERMAN; Fiscal Year: 2012
    ..which leads to excessive intracellular proteolysis, loss of membrane integrity, dissolution of sub-cellular architecture and necrotic cell death...
    Sridhar Sunderam; Fiscal Year: 2013
    ..they monitor mainly locomotor activity without providing information about sleep-wake state and sleep architecture, which are important for investigating sleep disorders...
  13. Fall risk assessment and prevention in elderly with diabetes using wearable techn
    Bor Rong Chen; Fiscal Year: 2012
    ..In the first phase of this study, we will improve the overall architecture of our initial prototype system for measuring lower extremity position in real time using wearable technology...
  14. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    JENNIFER E contact VAN EYK; Fiscal Year: 2010
    ..prove that blocking the TGFbeta pathway in the mouse with losartan, an AT1-anatgonist, normalizes aortic wall architecture. We recently demonstrated that circulating TGFbeta levels in the mouse model are significantly higher than in ..
    PALMER WILLIAM TAYLOR; Fiscal Year: 2013
    ..Since these proteins are found at synapses in the nervous system and mediate signaling events and synaptic architecture, they are important potential drug targets and indicators of genetic predisposition to certain disorders in the ..
  16. Aligned Tendon or Ligament Derived Matrix Nanoscaffolds for Rotator Cuff Repair
    Dianne Little; Fiscal Year: 2013
    ..for tissue engineering of a rotator cuff patch because the fibers can be aligned to mimic the natural architecture and biomechanical properties of native tissue...
  17. VITamin D and OmegA-3 TriaL: Effects on Bone Structure and Architecture
    MERYL SUSAN LEBOFF; Fiscal Year: 2013
    ..Recent advances in bone imaging make it possible to assess volumetric BMD (vBMD), structure, and micro- architecture non-invasively with high-resolution peripheral computed tomography (HR-pQCT)...
    Yoshio Yamaoka; Fiscal Year: 2013
    ..e., when the architecture of the gastric epithelium is disrupted in vivo)...
  19. Caveolins in the Pathogenesis of Idiopathic Pulmonary Fibrosis
    Dan N Predescu; Fiscal Year: 2010
    ..of extracellular material (mostly collagen like), that finally leads to irreversible destruction of lung architecture. The lack of knowledge of the mechanisms involved, along with the failure of all therapies used to date, are ..
  20. IGF-1, bone turnover and response to teriparatide in premenopausal women with IOP
    Adi Cohen; Fiscal Year: 2013
    ..The primary outcome variables of this trial are limited to BMD, micro- architecture and remodeling...
  21. The Role of the Nuclear Lamina in Chromatin Organization and Gene Expression in N
    Marcos Estecio; Fiscal Year: 2012
    ..Chromatin binding to the nuclear lamina dictates the genome architecture, bringing spatially close co-regulated genes and, through the action of insulators, compartmentalizes higher-..
  22. ECM compliance and cell cycle control
    RICHARD ASSOIAN; Fiscal Year: 2012
    ..The flexibility of an underlying substratum (its "compliance") has profound effects on cellular architecture, differentiation, and proliferation, raising the possibility that some of the signaling, differentiation, and ..
  23. Melanin-Concentrating Hormone: Ancestral Role in Feeding &Sleep Regulation
    Philippe Mourrain; Fiscal Year: 2013
    ..Finally, (iii) we will investigate the ancestral role for MCH in sleep- wake regulation by analyzing the sleep architecture during normal sleep, induced sleep, and after sleep deprivation...
    Katherine L Wilson; Fiscal Year: 2012
    ..the nuclear envelope, with functions that include signaling, chromatin silencing, gene regulation and nuclear architecture. Interestingly, emerin interacts with the DNA damage-response kinase, DNA-PK, in vivo, and emerin-downregulated ..
  25. Antigen receptor inputs: linking structural, molecular, and cellular responses
    Jonathan P Schneck; Fiscal Year: 2012
    ..the following areas: 1) Influence of TCR spatial organization on T cell responses, 2) Altered molecular architecture at the Immunological Synapse and T cell anergy, 3) Sprouty 1 as a novel inhibitor of T cell activation, 4) ..
    Philip B Wedegaertner; Fiscal Year: 2013
    ..proteins that couple diverse inputs to the activation of the small GTPase Rho and ultimately to dynamic cell architecture changes brought about by Rho's role in modifying a cell's actin cytoskeleton...
  27. Regulation of ENaC Transcription
    Bruce C Kone; Fiscal Year: 2013
    ..induced reprogramming at the ??ENaC promoter;and 3) Determine the dynamics, mediators, and roles of chromatin architecture in aldosterone-induced ??ENaC transcription...
  28. Structure and function of chloride channels and transporters
    Alessio Accardi; Fiscal Year: 2013
    ..It has been proposed that CLC transporters and channels share a common architecture. The third goal of this proposal is to test this hypothesis by transforming the former into the latter...
  29. Live cell imaging of IgH and c-Myc gene loci and the role of nuclear organization
    Mark T Groudine; Fiscal Year: 2010
    ..broad Challenge Area (15) Translational Science and specific Challenge Topic, 15-CA-101 The Role of Cellular Architecture in Normal and Tumor Cell Biology. The cell nucleus is a highly ordered organelle...
  30. Delayed pubertal development on the mechanism of bone loss at maturity
    Vanessa R Yingling; Fiscal Year: 2011
    ..Other factors including bone size, architecture and material properties must be considered...
  31. The Role of Long Non-coding RNAs in EMT and Cancer Stem Cells
    Jason I Herschkowitz; Fiscal Year: 2013 that many lncRNAs function through interactions with chromatin modifying complexes and control chromatin architecture. While a variety of functional roles for lncRNAs have been implicated in many biological processes, only in ..
  32. Function and Structure Adaptations in Forebrain Development
    PAT R LEVITT; Fiscal Year: 2013
    ..The goal of these studies is to define changes in dendritic and synaptic architecture, and in synaptic signaling systems...
  33. Osteoarthritis: Identification of Novel Imaging Biomarkers via 23Na/1H MRI at 7 T
    Gregory Chang; Fiscal Year: 2013
    ..thickness, volume, and proteoglycan content and subtle alterations in subchondral trabecular bone micro-architecture (trabecular thickness, number, separation, plate-to-rod ratio, and connectivity) in subjects with varying ..
  34. Role of Biophysical Cues in the Pathogenesis of Glaucoma
    Paul Russell; Fiscal Year: 2013
    ..This study would measure compliance of normal and glaucomatous HTM and then study HTM cell architecture, behavior and gene expression on surfaces that had similar compliances...
  35. Skin Regeneration with Stem Cells and Scaffolds
    SUSAN RENEE OPALENIK; Fiscal Year: 2013
    ..Healing by scarring results from the faulty, exuberant reconstruction of the dermal architecture and the formation of an epidermis lacking appendages...
  36. PTIP as an epigenetic regulator in male meiosis
    Guo Zhang Zhu; Fiscal Year: 2013 an epigenetic mark and is involved in the regulation of genome function through modifying chromatin architecture. Given dynamic chromatin remodeling in spermatogenesis, we recently generated a transgenic mouse model with ..
  37. Cytotoxic-T-Lymphocyte (CTL) Therapy of AML
    Bruce R Blazar; Fiscal Year: 2013
    ..receptor (LT[unreadable]R) mAb given to BMT recipients mediated restoration of CCL21 expression, improved LN architecture, increased LN size and T cell content, and augmented the endogenous immune response to pathogen, virus or AML ..
  38. The Thrifty Microbiome: The Role of the Gut Microbiota in Obesity in the Amish
    Alan R Shuldiner; Fiscal Year: 2010
    ..syndrome, and (iii) 50 nonobese subjects (BMI <25 kg/m2) without metabolic syndrome and characterize the architecture of the gut microbiota from the subjects enrolled in this study by high-throughput sequencing of 16S rRNA genes;(..
  39. Epidemiology of Putative Causal Variants in the Multiethnic Cohort
    Loic Le Marchand; Fiscal Year: 2012 RFA-HG-07-014, we propose to use the Multiethnic Cohort (MEC) study to characterize the "epidemiologic architecture" of putative causal variants identified in large-scale genomic association studies for a wide range of complex ..
  40. Identification of an Epigenetic Risk Marker for PTSD
    Rachel Yehuda; Fiscal Year: 2010
    ..provided by applicant): This grant responds to NIH Challenge 08-MH-103: Understanding the Genomic Risk Architecture of Mental Disorders...
  41. 3D human skin models
    Meenhard Herlyn; Fiscal Year: 2010
    ..Mouse skin is significantly different from human skin in its architecture and varies in response to environmental toxins (biological origin) and xenobiotics (synthetic chemicals)...
  42. Epigenome Mapping in Cortical Interneurons
    Schahram Akbarian; Fiscal Year: 2013
    ..histone methylation mapping of specific interneuron types is likely to provide radically novel insights into the developmental history and (epi)genomic architecture of cells ascribed a key role in schizophrenia and related disease.
  43. Noncoding RNAs as epigenomic modulators in Alzheimer's Disease
    CLAES ROBERT WAHLESTEDT; Fiscal Year: 2010
    ..Several functions proposed for ncRNA, among them regulation of chromatin architecture and epigenetic memory, have received much attention...
  44. Biomarkers in HPA axis and inflammatory pathways for suicidal behavior in youth
    Nadine M Melhem; Fiscal Year: 2013
    ..biological signatures, or biomarkers, for psychiatric diseases that will improve our understanding of their architecture of risk and methods of diagnosis and treatment, as their public health burden continues to grow alarmingly...
  45. Stem cells for novel gene delivery of nitric oxide in the gut
    Hiroshi Mashimo; Fiscal Year: 2013 the adult pylorus, these cells remained in the area, reconstituted the native tissues, respected the local architecture, and continued to express NO...
  46. Integration of Signaling Pathways Regulating Chondrocyte Differentiation
    Sherrill L Adams; Fiscal Year: 2010
    ..that alterations in binding of transcription factors and comodulators that alter promoter and chromatin architecture are responsible for the dramatic increase in Col10 that occur during chondrocyte maturation in vivo and in ..
  47. Identification of a Molecular Signature for Barrier Insulators
    LAURIE ANN STEINER; Fiscal Year: 2013
    ..sequencing (ChIP-seq) to create genome-wide maps of barrier insulator- associated factor binding and chromatin architecture in primary nucleated human erythoid cells...
  48. New Approaches to the Evaluation and Treatment of Acromegaly
    Pamela U Freda; Fiscal Year: 2013
    ..Utilizing the novel assessment of bone architecture by HRpQCT along will BMD, fracture prevalence and bone metabolism marker measurements we will determine, among ..
  49. RPE Phenotype and Oxidative Stress
    Janice M Burke; Fiscal Year: 2013
    ..called organelles, which must be effectively and continuously moved to achieve the most efficient cell architecture. Antioxidants will also be tested to see if binding them to organelles helps the RPE sustain normal organelle ..
  50. Targeted epigenetic silencing of oncogenic Transcription Factors (PQ18)
    Pilar Blancafort; Fiscal Year: 2013
    ..DNAme orchestrate other epigenetic modifications, shaping the architecture of the promoter and driving chromatin condensation and gene silencing...
  51. Role of Cofilin and Wnt Signaling in Neural Crest Development
    O apos NEIL WIGGAN; Fiscal Year: 2013
    ..We hypothesize that non canonical Wnt signaling dictates cell morphology, actin cytoskeleton architecture and polarized cell migration through regulation of cofilin activity...
  52. Mechanisms for the evolution of novel DNA specificity in a transcription factor f
    Joseph W Thornton; Fiscal Year: 2013
    ..This complete causal chain will elucidate how the biophysical architecture of extant proteins evolved and how that architecture structured the evolutionary genetic process...
    GEORGIRENE VLADUTIU; Fiscal Year: 2012
    ..Our hypothesis is that the genetic architecture of susceptibility to statin myopathy is complex and will include an increased prevalence of underlying ..
  54. CT imaging for the assessment of kidney injury distal to renal artery stenosis
    Lilach O Lerman; Fiscal Year: 2013
    ..The secondary hypothesis is that imaging techniques can resolve MV function and architecture to allow demonstration of the renal effects of MetS and exploration of its mechanisms...
  55. Recombinant Antibodies from the Sea Lamprey
    ZEEV contact PANCER; Fiscal Year: 2010
    ..These include the complex architecture of their antigen- binding sites, which complicates the generation of synthetic antibody libraries, and major ..
  56. Kinase/Phosphatase-mediated Mitochondrial Restructuring in Neuroprotection
    Stefan Strack; Fiscal Year: 2012
    ..Mitochondrial architecture, as determined by opposing fission and fusion reactions, has recently emerged as a critical determinant for ..
  57. The Pox Virion Molecular Interactome
    Paul D Gershon; Fiscal Year: 2013
    ..This intervening area may be referred to as the virion's "molecular architecture", or protein "interactome". In this R21 proposal, the P.I...
  58. Inhibition of HIV-Induced Synaptodentritic Damage
    Val S Goodfellow; Fiscal Year: 2013
    ..Tat-induced leukocyte infiltration and microglial activation, and reverses Tat-induced damage to synaptic architecture. Damage to synaptic architecture is the key pathological process of HAND in cognition and memory impairment...
  59. Self-Sensing Physiologic Control of a Rotary Mag Lev LVAD
    JAMES FARLEY WALTON; Fiscal Year: 2010
    ..The physiologic control algorithms and architecture developed under Phase I will be implemented in a dSpace digital control hardware system...
  60. Calcium Signaling, Metabolism, and EC Coupling in Heart
    Joshua I Goldhaber; Fiscal Year: 2013
    ..In particular, alterations in calcium spark and spike formation and cellular micro-architecture of the transverse-tubule system as a cause of the functional loss of couplons during metabolic inhibition will ..
  61. Light-Alarming Personal Noise Dosimeter System
    ALEXANDER MILOVANOV; Fiscal Year: 2013
    ..In Phase I POC will develop a LAND system architecture that provides accurate noise level and noise exposure measurement and effective visual alerts of sound hazard...
  62. Exploiting toxins to probe sensory signaling
    David Julius; Fiscal Year: 2012
    ..Little is currently known about TRP channel architecture or gating mechanisms, and comparison of our findings with data from the voltage-gated channel field will ..
  63. Expressions of Specialized Collagens in the Cornea
    Marion K Gordon; Fiscal Year: 2010
    The cornea uses extracellular matrix (ECM) molecules, in particular, collagens, to set up an architecture that serves two crucial functions: refraction and transmission of light...
    Dan Wiginton; Fiscal Year: 2006
    EXCEED THE SPACE PROVIDED. The epithelium of mammalian small intestine has a complex, but highly defined architecture. The primary components of this architecture are the crypt and villus...
    Csaba Horvath; Fiscal Year: 1993
    ..that on separation phenomena with polymeric sorbents and supports where the morphology, surface and molecular architecture as well as the dynamics of interaction between the functionalized polymer and sorbate are the major subjects of ..
  66. Structure and mechanism of the AMP-activated protein kinase
    Lawrence Shapiro; Fiscal Year: 2010
    ..This complex lacks the kinase catalytic domain, but reveals the conserved trimeric core architecture of AMPKs...
    Sharmila Majumdar; Fiscal Year: 1999
    ..therapies, one of the requirements will be the ability to assess non-invasively, measures of trabecular architecture and mechanical strength, and predict the efficacy of different therapeutic regimes...
  68. Quantification of Regional Lung Disease by Computed Tomography
    Cuneyt Yilmaz; Fiscal Year: 2010
    ..The unique features of the lung, i.e., its non-solid, elastic architecture, render the organ highly sensitive to volume change and to asymmetric distortion due to regional disease ..
  69. Visual-social cognition in neurodevelopmental disorders
    Nouchine Hadjikhani; Fiscal Year: 2004
    ..Neuroimaging techniques have the potential to reveal aspects of the underlying architecture and function of visual processing...
  70. Local Signals and Macromolecular Architecture in Heart
    Terry Rogers; Fiscal Year: 2006
    ..Project 1 will examine the role of phosphatases in control of cytoskeletal architecture at t-tubules (link to Project 2) and L-type Ca2+ channel function (link to Project 4)...
  71. From Pavilions to Skyscrapers: A History of Healthy Hospital Design in New York C
    JEANNE KISACKY; Fiscal Year: 2009
    ..Between the nineteenth and twentieth centuries in New York City, 'ideal'hospital architecture shifted from a self-purifying environment intended to minimize the internal spread of specific diseases to a ..
  72. Determinants of Phenotype in Retinal Pigment Epithelium
    Janice Burke; Fiscal Year: 2007
    ..adjacent retinal photoreceptors, an interaction which requires that RPE cells maintain a specific cellular architecture. How this architecture comes about is not well understood, and when it is lost as a consequence of injury or ..