beta synuclein


Summary: A synuclein that is closely related to ALPHA-SYNUCLEIN. It may play a neuroprotective role against some of the toxic effects of aggregated ALPHA-SYNUCLEIN.

Top Publications

  1. Wersinger C, Sidhu A. Partial regulation of serotonin transporter function by gamma-synuclein. Neurosci Lett. 2009;453:157-61 pubmed publisher
    ..These studies document a novel physiological role for gamma-Syn in regulating 5-HT synaptic availability and homeostasis, and may be of relevance in depression and mood disorders, where SERT function is dysregulated. ..
  2. Fujita M, Sekigawa A, Sekiyama K, Sugama S, Hashimoto M. Neurotoxic conversion of beta-synuclein: a novel approach to generate a transgenic mouse model of synucleinopathies?. J Neurol. 2009;256 Suppl 3:286-92 pubmed publisher
    ..Furthermore, it is expected that a bigenic mouse model for mutant beta-syn/alpha-syn might be characterized by a more accelerated phenotype of synucleinopathies. ..
  3. JEANNOTTE A, McCarthy J, Sidhu A. Desipramine induced changes in the norepinephrine transporter, alpha- and gamma-synuclein in the hippocampus, amygdala and striatum. Neurosci Lett. 2009;467:86-9 pubmed publisher
  4. Mbefo M, Paleologou K, Boucharaba A, Oueslati A, Schell H, Fournier M, et al. Phosphorylation of synucleins by members of the Polo-like kinase family. J Biol Chem. 2010;285:2807-22 pubmed publisher
  5. Adamczyk A, Czapski G, Kaźmierczak A, Strosznajder J. Effect of N-methyl-D-aspartate (NMDA) receptor antagonists on alpha-synuclein-evoked neuronal nitric oxide synthase activation in the rat brain. Pharmacol Rep. 2009;61:1078-85 pubmed
    ..We suggest that nitric oxide liberated by the over-activated neuronal isoform of NOS could react with superoxide to form peroxynitrite, which modulates the function of a variety of biomolecules including proteins, lipids, and DNA. ..
  6. Varkey J, Isas J, Mizuno N, Jensen M, Bhatia V, Jao C, et al. Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins. J Biol Chem. 2010;285:32486-93 pubmed publisher
    ..How cellular safeguarding mechanisms prevent such potentially toxic events and whether they go awry in disease remains to be determined. ..
  7. Zibaee S, Fraser G, Jakes R, Owen D, Serpell L, Crowther R, et al. Human beta-synuclein rendered fibrillogenic by designed mutations. J Biol Chem. 2010;285:38555-67 pubmed publisher
    ..The implications for filament formation and the pathogenesis of neurodegenerative diseases are discussed. ..
  8. Kela Madar N, de Rosbo N, Ronen A, Mor F, Ben Nun A. Autoimmune spread to myelin is associated with experimental autoimmune encephalomyelitis induced by a neuronal protein, beta-synuclein. J Neuroimmunol. 2009;208:19-29 pubmed publisher
  9. Faure J, Hattingh S, Stein D, Daniels W. Proteomic analysis reveals differentially expressed proteins in the rat frontal cortex after methamphetamine treatment. Metab Brain Dis. 2009;24:685-700 pubmed publisher
    ..Proteomic research may be useful in exploring the complex underlying molecular mechanisms of MA dependence. ..

More Information


  1. Fuller B, Gold M, Wang K, Ottens A. Effects of environmental tobacco smoke on adult rat brain biochemistry. J Mol Neurosci. 2010;41:165-71 pubmed publisher
    ..These findings demonstrate that ETS exposure alters the neuroproteome of the adult rat brain, and suggest modulation of inflammatory and cell death processes. ..
  2. Nishioka K, Wider C, Vilariño Güell C, Soto Ortolaza A, Lincoln S, Kachergus J, et al. Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease. Arch Neurol. 2010;67:970-5 pubmed publisher
    ..To determine the association of the genes that encode alpha-, beta-, and gamma-synuclein (SNCA, SNCB, and SNCG, respectively) with diffuse Lewy body disease (DLBD)...
  3. Larsen K, Frandsen P, Madsen L, Bendixen C. Molecular cloning, characterization and developmental expression of porcine beta-synuclein. Mol Biol Rep. 2010;37:1439-49 pubmed publisher
    ..The subcellular localization of recombinant porcine beta-synuclein was determined in three different cell types and shown to be cytoplasmic. ..
  4. Wei J, Fujita M, Nakai M, Waragai M, Sekigawa A, Sugama S, et al. Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies. Am J Pathol. 2009;174:1891-909 pubmed publisher
    ..These data suggest that endogenous gangliosides may play protective roles against the lysosomal pathology of synucleinopathies. ..
  5. Ito S, Nakaso K, Imamura K, Takeshima T, Nakashima K. Endogenous catecholamine enhances the dysfunction of unfolded protein response and alpha-synuclein oligomerization in PC12 cells overexpressing human alpha-synuclein. Neurosci Res. 2010;66:124-30 pubmed publisher
    ..Therefore, these findings suggest that the coexistence of human alpha-synuclein with catecholamine enhances the endoplasmic reticulum stress-related toxicity in PD pathogenesis. ..
  6. Ye Q, Wang T, Peng Y, Xie J, Feng B, Qiu M, et al. Expression of alpha-, beta- and gamma-synuclein in colorectal cancer, and potential clinical significance in progression of the disease. Oncol Rep. 2010;23:429-36 pubmed
  7. Greten Harrison B, Polydoro M, Morimoto Tomita M, Diao L, Williams A, Nie E, et al. αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction. Proc Natl Acad Sci U S A. 2010;107:19573-8 pubmed publisher
    ..Our results demonstrate that synucleins contribute importantly to the long-term operation of the nervous system and that alterations in their physiological function could contribute to the development of Parkinson's disease. ..