superior colliculus


Top Publications

  1. Honda H. Competition between retinal ganglion axons for targets under the servomechanism model explains abnormal retinocollicular projection of Eph receptor-overexpressing or ephrin-lacking mice. J Neurosci. 2003;23:10368-77 pubmed
    ..The retina has an increasing nasal-to-temporal gradient of Eph receptor density, and the optic tectum/superior colliculus has an increasing rostral-to-caudal gradient of membrane-bound ephrin ligand...
  2. Feldheim D, Nakamoto M, Osterfield M, Gale N, DeChiara T, Rohatgi R, et al. Loss-of-function analysis of EphA receptors in retinotectal mapping. J Neurosci. 2004;24:2542-50 pubmed
  3. Hindges R, McLaughlin T, Genoud N, Henkemeyer M, O Leary D. EphB forward signaling controls directional branch extension and arborization required for dorsal-ventral retinotopic mapping. Neuron. 2002;35:475-87 pubmed
    ..required for mapping the dorsal-ventral (D-V) retinal axis along the lateral-medial (L-M) axis of the superior colliculus (SC)...
  4. Nuschke A, Farrell S, Levesque J, Chauhan B. Assessment of retinal ganglion cell damage in glaucomatous optic neuropathy: Axon transport, injury and soma loss. Exp Eye Res. 2015;141:111-24 pubmed publisher
    ..Retrograde tracers can be used to quantify RGC populations in rodents via application to the superior colliculus (SC)...
  5. Wang Y, Huang P, Ung A, Blendy J, Liu Chen L. Reduced expression of the μ opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G. Neuroscience. 2012;205:178-84 pubmed publisher
    ..accumbens core and shell, hypothalamus, thalamus, amygdala, periaqueductal gray, superficial gray of superior colliculus, and ventral tegmental area...
  6. Chiasseu M, Alarcón Martínez L, Belforte N, Quintero H, Dotigny F, Destroismaisons L, et al. Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer's disease. Mol Neurodegener. 2017;12:58 pubmed publisher
    ..of the cholera toxin beta subunit followed by quantification of tracer accumulation in the contralateral superior colliculus. RGC survival was analyzed on whole-mounted retinas using cell-specific markers...
  7. Elkins E, Walti K, Newberry K, Lema S. Identification of an oxytocinase/vasopressinase-like leucyl-cystinyl aminopeptidase (LNPEP) in teleost fish and evidence for hypothalamic mRNA expression linked to behavioral social status. Gen Comp Endocrinol. 2017;250:58-69 pubmed publisher
  8. Cavdar S, Ozgur M, Cakmak Y, Kuvvet Y, Kunt S, Sağlam G. Afferent projections of the subthalamic nucleus in the rat: emphasis on bilateral and interhemispheric connections. Acta Neurobiol Exp (Wars). 2018;78:251-263 pubmed
    ..thalamic (thalamic reticular nucleus), epithalamic (habenular nucleus), and brainstem structures (superior colliculus, substantia nigra, spinal nucleus of the trigeminal nerve, red nucleus, dorsal raphe nucleus, ..
  9. Tuziak S, Rise M, Volkoff H. An investigation of appetite-related peptide transcript expression in Atlantic cod (Gadus morhua) brain following a Camelina sativa meal-supplemented feeding trial. Gene. 2014;550:253-63 pubmed publisher

More Information


  1. Wilson G, Smith M, Inman D, Dengler Crish C, Crish S. Early Cytoskeletal Protein Modifications Precede Overt Structural Degeneration in the DBA/2J Mouse Model of Glaucoma. Front Neurosci. 2016;10:494 pubmed
    ..145/150 kDa), ?-tubulin, and amyloid-?42 proteins based on age and transport outcome to the superior colliculus (SC; the main retinal target in mice)...
  2. Rodriguez V, Mendoza Trejo M, Hernandez Plata I, Giordano M. Behavioral effects and neuroanatomical targets of acute atrazine exposure in the male Sprague-Dawley rat. Neurotoxicology. 2017;58:161-170 pubmed publisher
    ..and increases in the number of c-Fos-positive cells in thalamus, central amygdala, subthalamic nucleus, superior colliculus, and substantia nigra, TH positive cells were not selectively activated by ATR...
  3. Weaver C, Terzi A, Roeder H, Gurol T, Deng Q, Leung Y, et al. nox2/cybb Deficiency Affects Zebrafish Retinotectal Connectivity. J Neurosci. 2018;38:5854-5871 pubmed publisher
    ..Using mutant zebrafish embryos, this study shows that a specific Nox isoform, Nox2/Cybb, is important for the establishment of axonal connections between retinal ganglion cells and the optic tectum. ..
  4. Muthuraju S, Talbot T, Brandão M. Dopamine D2 receptors regulate unconditioned fear in deep layers of the superior colliculus and dorsal periaqueductal gray. Behav Brain Res. 2016;297:116-23 pubmed publisher
    Electrical and chemical stimulation of the dorsal periaqueductal gray (dPAG), deep layers of the superior colliculus (dlSC), and inferior colliculus (IC) causes freezing and escape behavior in rodents...
  5. Kim B, Silverman S, Liu Y, Wordinger R, Pang I, Clark A. In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells. Mol Neurodegener. 2016;11:30 pubmed publisher
    ..Retinal function was measured by scotopic flash electroretinography (ERG). Volumetric measurement of the superior colliculus (SC) as well as VGLUT2 and PSD95 expression were studied...
  6. Aliaga Guerrero M, Paullada Salmerón J, Piquer V, Mañanós E, Muñoz Cueto J. Gonadotropin-inhibitory hormone in the flatfish, Solea senegalensis: molecular cloning, brain localization and physiological effects. J Comp Neurol. 2017;: pubmed publisher
  7. Cacialli P, Gueguen M, Coumailleau P, D angelo L, Kah O, Lucini C, et al. BDNF Expression in Larval and Adult Zebrafish Brain: Distribution and Cell Identification. PLoS ONE. 2016;11:e0158057 pubmed publisher
    ..Our results provide the first demonstration that the brain of zebrafish expresses bdnf mRNAs in neurons and open new fields of research on the role of the BDNF factor in brain mechanisms in normal and brain repairs situations. ..
  8. Simmons A, Bloomsburg S, Billingslea S, Merrill M, Li S, Thomas M, et al. Pou4f2 knock-in Cre mouse: A multifaceted genetic tool for vision researchers. Mol Vis. 2016;22:705-17 pubmed
    ..recombination in about 15% of cells within the superchiasmatic nucleus, lateral geniculate nucleus, and superior colliculus. Pou4f2(Cre) provides multiple uses for the vision researcher's genetic toolkit...
  9. You S, Hellström M, Pollett M, LeVaillant C, Moses C, Rigby P, et al. Large-scale reconstitution of a retina-to-brain pathway in adult rats using gene therapy and bridging grafts: An anatomical and behavioral analysis. Exp Neurol. 2016;279:197-211 pubmed publisher
    ..sciatic nerve was sutured onto the transected ON and the distal end immediately inserted into contralateral superior colliculus (SC). Control rats received intraocular injections of saline or adeno-associated virus (AAV) encoding GFP...
  10. Phang Y, Soga T, Kitahashi T, Parhar I. Cloning and functional expression of novel cholesterol transporters ABCG1 and ABCG4 in gonadotropin-releasing hormone neurons of the tilapia. Neuroscience. 2012;203:39-49 pubmed publisher
  11. Kittilson J, Slagter B, Martin L, Sheridan M. Isolation, characterization, and distribution of somatostatin receptor subtype 2 (SSTR 2) mRNA in rainbow trout (Oncorhynchus mykiss), and regulation of its expression by glucose. Comp Biochem Physiol A Mol Integr Physiol. 2011;160:237-44 pubmed publisher
    ..These findings contribute to the understanding of the evolution of the SSTR family and provide insight into the roles of SSTR 2 in fish. ..
  12. Velaz Faircloth M, McGraw T, alandro M, Fremeau R, Kilberg M, Anderson K. Characterization and distribution of the neuronal glutamate transporter EAAC1 in rat brain. Am J Physiol. 1996;270:C67-75 pubmed
    ..EAAC1 mRNA had the highest density in the cerebellar granule cell layer, hippocampus, superior colliculus, and neocortex...
  13. Almada R, Roncon C, Elias Filho D, Coimbra N. Endocannabinoid signaling mechanisms in the substantia nigra pars reticulata modulate GABAergic nigrotectal pathways in mice threatened by urutu-cruzeiro venomous pit viper. Neuroscience. 2015;303:503-14 pubmed publisher
    ..acid (GABA)-ergic neurons and connected to the mesencephalic tectum (MT) structures, such as the superior colliculus and dorsal periaqueductal gray matter...
  14. Tingaud Sequeira A, Raldúa D, Lavie J, Mathieu G, Bordier M, Knoll Gellida A, et al. Functional validation of ABHD12 mutations in the neurodegenerative disease PHARC. Neurobiol Dis. 2017;98:36-51 pubmed publisher
    ..Zebrafish may provide a suitable vertebrate model for ABHD12 insufficiency and the study of functional impairment and potential therapeutic rescue of this rare, neurodegenerative disease. ..
  15. Abaei M, Sagar D, Stockley E, Spicer C, Prior M, Chapman V, et al. Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain. Mol Pain. 2016;12: pubmed publisher
    ..Taken together, our data support altered neural pain processing as a result of peripheral and central pain sensitization in this model. ..
  16. De Groef L, Dekeyster E, Geeraerts E, Lefevere E, Stalmans I, Salinas Navarro M, et al. Differential visual system organization and susceptibility to experimental models of optic neuropathies in three commonly used mouse strains. Exp Eye Res. 2016;145:235-247 pubmed publisher
    ..ganglion cell density, also the retinofugal projections to the dorsal lateral geniculate nucleus and the superior colliculus revealed striking differences, potentially underlying diverging optokinetic tracking responses and visual ..
  17. Downs A, Scholles K, Hollis D. Localization of rem2 in the central nervous system of the adult rainbow trout (Oncorhynchus mykiss). J Chem Neuroanat. 2016;78:87-95 pubmed publisher
    ..These data indicate that rem2 gene expression is broadly distributed and likely influences diverse functions in the adult fish central nervous system. ..
  18. Stonestreet B, McKnight A, Sadowska G, Petersson K, Oen J, Patlak C. Effects of duration of positive-pressure ventilation on blood-brain barrier function in premature lambs. J Appl Physiol (1985). 2000;88:1672-7 pubmed
    ..min (mean), 162-474 min (range)] in the cerebral cortex, cerebellum, medulla, caudate nucleus, hippocampus, superior colliculus, inferior colliculus, thalamus, pons, cervical spinal cord, and choroid plexus, but not in the pituitary ..