Summary: Pain in the adjacent areas of the teeth.

Top Publications

  1. Skaret E, Berg E, Kvale G, Raadal M. Psychological characteristics of Norwegian adolescents reporting no likelihood of visiting a dentist in a situation with toothache. Int J Paediatr Dent. 2007;17:430-8 pubmed
    ..of 18-year-old adolescents: (i) subjects reporting no likelihood of visiting the dentist in a situation with toothache (avoiders); and (ii) subjects who definitely would see the dentist in the same situation (non-avoiders)...
  2. Versloot J, Veerkamp J, Hoogstraten J. The Dental Discomfort Questionnaire: the basis of a 'Toothache Traffic Light'. Eur Arch Paediatr Dent. 2009;10:67-70 pubmed
    ..the studies done with the Dental Discomfort Questionnaires (DDQ) and second to present a behaviour checklist, a 'Toothache Traffic Light', based on the DDQ, which could possibly be used to raise awareness for toothache among parents ..
  3. Barrêtto E, Paiva S, Pordeus I, Ferreira e Ferreira E. Validation of a child dental pain questionnaire instrument for the self-reporting of toothache in Children. Pediatr Dent. 2011;33:228-32 pubmed
    ..The child-DPQ is structured to measure toothache using 3 subscales: (1) prevalence; (2) severity; and (3) impact on daily life...
  4. Bastos J, Gigante D, Peres K, Nedel F. [Social determinants of odontalgia in epidemiological studies: theoretical review and proposed conceptual model]. Cien Saude Colet. 2007;12:1611-21 pubmed
    ..Aspects of the social structure are highlighted in order to relate them to odontalgia, stressing their importance in discussions of causal relationships in oral health research. ..
  5. Baad Hansen L. Atypical odontalgia - pathophysiology and clinical management. J Oral Rehabil. 2008;35:1-11 pubmed publisher
    ..Two illustrative cases are presented. ..
  6. Nixdorf D, Moana Filho E, Law A, McGuire L, Hodges J, John M. Frequency of persistent tooth pain after root canal therapy: a systematic review and meta-analysis. J Endod. 2010;36:224-30 pubmed publisher
    ..The frequency of all-cause persistent tooth pain after endodontic procedures was estimated to be 5.3%, with higher report quality studies suggesting >7%. ..
  7. Nissenbaum M, Kaban L, Troulis M. Toothache, paresthesia, and Horner syndrome: an unusual presentation of disseminated Burkitt's lymphoma. J Oral Maxillofac Surg. 2007;65:1395-401 pubmed
  8. List T, Leijon G, Svensson P. Somatosensory abnormalities in atypical odontalgia: A case-control study. Pain. 2008;139:333-41 pubmed publisher
    ..More generalized sensitization of the nociceptive system may also be part of AO pathophysiology. ..
  9. Mukherjee B, Roy G, Ghosh S. Development of Denticap, a matrix based sustained release formulation for treatment of toothache, dental infection and other gum problem. Curr Drug Deliv. 2009;6:199-207 pubmed
    b>Toothache is a serious problem worldwide. To give relief from this intolerable toothache, doctors prescribe painkillers along with antibiotics...

More Information


  1. Bastos J, Peres M, Peres K, Araujo C, Menezes A. Toothache prevalence and associated factors: a life course study from birth to age 12 yr. Eur J Oral Sci. 2008;116:458-66 pubmed publisher
    This study estimated the lifetime prevalence of toothache at ages 6 and 12 yr, the prevalence of toothache during the last month, and their association with social, behavioural and clinical exposures in the course of life of 339 12-yr-..
  2. Freire M, Leles C, Sardinha L, Paludetto Junior M, Malta D, Peres M. [Dental pain and associated factors in Brazilian adolescents: the National School-Based Health Survey (PeNSE), Brazil, 2009]. Cad Saude Publica. 2012;28 Suppl:s133-45 pubmed
    ..Dental pain was thus associated with socio-demographic factors and health-related behaviors. ..
  3. Peres M, Peres K, Frias A, Antunes J. Contextual and individual assessment of dental pain period prevalence in adolescents: a multilevel approach. BMC Oral Health. 2010;10:20 pubmed publisher
    ..Students from areas with low Human Development Index had higher prevalence of dental pain than those from the more developed areas regardless of individual characteristics. ..
  4. Lewis C, Stout J. Toothache in US children. Arch Pediatr Adolesc Med. 2010;164:1059-63 pubmed publisher
    To describe the prevalence of and risk factors for recent toothache among US children and to estimate frequency of contact between children with toothache and their pediatric primary care providers (PPCP)...
  5. Pau A, Khan S, Babar M, Croucher R. Dental pain and care-seeking in 11-14-yr-old adolescents in a low-income country. Eur J Oral Sci. 2008;116:451-7 pubmed publisher
    ..The findings substantiate dental pain as an important dental public health concern in Pakistan and support the hypothesis that assessment of dental pain characteristics can add to the accuracy of dental need estimation. ..
  6. Lin M, Xu F, Lu T, Bai B. A review of heat transfer in human tooth--experimental characterization and mathematical modeling. Dent Mater. 2010;26:501-13 pubmed publisher
    ..Limitations of the current experimental and mathematical methodologies are discussed and potential solutions are suggested. Interpretation of TTP in terms of thermally stimulated dentinal fluid flow is also discussed...
  7. List T, Leijon G, Helkimo M, Oster A, Dworkin S, Svensson P. Clinical findings and psychosocial factors in patients with atypical odontalgia: a case-control study. J Orofac Pain. 2007;21:89-98 pubmed
    ..Significant limitation in jaw function and significantly lower scores on quality of life measures were found for AO patients compared with controls. ..
  8. Moure Leite F, Ramos Jorge J, Ramos Jorge M, Paiva S, Vale M, Pordeus I. Impact of dental pain on daily living of five-year-old Brazilian preschool children: prevalence and associated factors. Eur Arch Paediatr Dent. 2011;12:293-7 pubmed
    ..001), missing teeth (p<0.001), filled teeth (p<0.001) and caries involving pulp (p<0.001). The prevalence of difficulties performing tasks of daily living due to dental pain was relatively high among the children studied. ..
  9. Bastos J, Gigante D, Peres K. Toothache prevalence and associated factors: a population based study in southern Brazil. Oral Dis. 2008;14:320-6 pubmed
    The aim of this study was to estimate toothache prevalence and associated factors among adult residents in Pelotas, a southern Brazilian city...
  10. Baad Hansen L, Leijon G, Svensson P, List T. Comparison of clinical findings and psychosocial factors in patients with atypical odontalgia and temporomandibular disorders. J Orofac Pain. 2008;22:7-14 pubmed
    ..AO and TMD share some characteristics but differ significantly in report of dental trauma, jaw function, pain duration, and pain site. ..
  11. Goes P, Watt R, Hardy R, Sheiham A. Impacts of dental pain on daily activities of adolescents aged 14-15 years and their families. Acta Odontol Scand. 2008;66:7-12 pubmed publisher
    ..7 nights per week. Dental pain has considerable impact on the daily lives of adolescents and their families in Brazil. There are many more dental pain-related impacts in girls and in lower social class children. ..
  12. Cohen L, Bonito A, Akin D, Manski R, Macek M, Edwards R, et al. Toothache pain: a comparison of visits to physicians, emergency departments and dentists. J Am Dent Assoc. 2008;139:1205-16 pubmed
    ..Participants included low-income white, African-American and Hispanic adults who had experienced a toothache during the previous 12 months...
  13. Caviedes Bucheli J, Munoz H, Azuero Holguin M, Ulate E. Neuropeptides in dental pulp: the silent protagonists. J Endod. 2008;34:773-88 pubmed publisher
  14. Goes P, Watt R, Hardy R, Sheiham A. The prevalence and severity of dental pain in 14-15 year old Brazilian schoolchildren. Community Dent Health. 2007;24:217-24 pubmed
    ..1,052 individuals participated in the study. The prevalence of reported toothache in schoolchildren in the last six months was 33.6% (31.1-36.8, 95% CI)...
  15. Anderson R, Thomas D. 'Toothache stories': a qualitative investigation of why and how people seek emergency dental care. Community Dent Health. 2003;20:106-11 pubmed
    ..non-dentists, expectations concerning what work dentists should do, and what symptoms distinguish "simple toothache" from more serious problems...
  16. Pau A, Croucher R, Marcenes W. Perceived inability to cope and care-seeking in patients with toothache: a qualitative study. Br Dent J. 2000;189:503-6 pubmed
    ..the subjective experience of a sample of patients attending a dental teaching hospital emergency clinic with toothache. Subjects 21 female and 14 male dental patients, of different ages, marital status, employment status and levels ..
  17. Versloot J, Veerkamp J, Hoogstraten J. Dental Discomfort Questionnaire: predicting toothache in preverbal children. Eur J Paediatr Dent. 2004;5:170-3 pubmed
    In the present study the value of the Dental Discomfort Questionnaire in predicting toothache in young children is analysed. The Dental Discomfort Questionnaire (DDQ-8; Cronbach's alpha 0...
  18. Hellmann D. Temporal arteritis: a cough, toothache, and tongue infarction. JAMA. 2002;287:2996-3000 pubmed
    ..The condition is illustrated in this article by the case of a 79-year-old woman with a dry cough, toothache, tongue infarction, and vision loss...
  19. Moncada E, Graff Radford S. Cough headache presenting as a toothache: a case report. Headache. 1993;33:240-3 pubmed
    ..experienced in BCH are subarachnoid hemorrhage, increased intracranial pressure, intracranial tumors, and even toothache. Careful evaluation must be carried out in order to differentiate between these conditions...
  20. Madinier I. Illicit drugs for toothache. Br Dent J. 2002;192:120 pubmed
  21. Gupta V, Chandrasekar T, Ramani P. Determining toothache severity in pediatric patients: A study. J Indian Soc Pedod Prev Dent. 2006;24:140-3 pubmed
    To correlate sodium-potassium levels in saliva of pediatric patients having different intensities of toothache assessed by Visual Analogue Scale (VAS) in age group 3-14 yrs...
  22. Duncan R, Gilbert G, Peek C, Heft M. The dynamics of toothache pain and dental services utilization: 24-month incidence. J Public Health Dent. 2003;63:227-34 pubmed
    The aims of this study were twofold: (1) to describe patterns of change in reported toothache pain, and (2) to examine the impact of toothache pain on dental care utilization and vice versa...
  23. Hersh E, DeRossi S, Ciarrocca K, Secreto S, Ghassemi A. Efficacy and tolerability of an intraoral benzocaine patch in the relief of spontaneous toothache pain. J Clin Dent. 2003;14:1-6 pubmed
    ..patch was evaluated in 60 patients who presented to the Dental School's emergency clinic with spontaneous toothache pain of at least a moderate intensity...
  24. Okajima Y, Hirai A, Higashi M, Harigaya K. Vasospastic angina in a 13-year-old female patient whose only symptom was toothache. Pediatr Cardiol. 2007;28:68-71 pubmed
    ..The patient's only symptom was recurrent toothache, which began when she was 10 years old...
  25. Kreiner M, Okeson J. Toothache of cardiac origin. J Orofac Pain. 1999;13:201-7 pubmed
    ..This article reviews the literature concerning referred pain of cardiac origin and presents a case report of toothache of cardiac origin.
  26. Adulyanon S, Vourapukjaru J, Sheiham A. Oral impacts affecting daily performance in a low dental disease Thai population. Community Dent Oral Epidemiol. 1996;24:385-9 pubmed
    ..1%) for almost every performance except Smiling. Toothache was the major causal oral condition (32.7%) of almost all aspects of performance...
  27. Rodd H, Boissonade F. Substance P expression in human tooth pulp in relation to caries and pain experience. Eur J Oral Sci. 2000;108:467-74 pubmed
    ..These data would suggest that the expression of SP within pulpal nerves undergoes dynamic changes following caries, which may have an important clinical significance in terms of inflammation and pain experience. ..
  28. Lavigne G, Woda A, Truelove E, Ship J, Dao T, Goulet J. Mechanisms associated with unusual orofacial pain. J Orofac Pain. 2005;19:9-21 pubmed
  29. Okullo I, Astrøm A, Haugejorden O. Social inequalities in oral health and in use of oral health care services among adolescents in Uganda. Int J Paediatr Dent. 2004;14:326-35 pubmed
    ..urban resident was associated with higher odds for having dental caries (dmft > 0), seeking care because of toothache (delayed treatment demand) and being dissatisfied with one's own oral health status [adjusted odds ratio (OR) = ..
  30. Ståhlnacke K, Soderfeldt B, Unell L, Halling A, Axtelius B. Perceived oral health: changes over 5 years in one Swedish age-cohort. Community Dent Oral Epidemiol. 2003;31:292-9 pubmed
    ..This index value was set as a dependent variable in a regression model. Reports of toothache were investigated in a separate logistic regression model...
  31. Lacerda J, Simionato E, Peres K, Peres M, Traebert J, Marcenes W. [Dental pain as the reason for visiting a dentist in a Brazilian adult population]. Rev Saude Publica. 2004;38:453-8 pubmed
    ..These factors are determined by social conditions and represented by the schooling level. ..
  32. Naidoo S, Chikte U, Sheiham A. Prevalence and impact of dental pain in 8-10-year-olds in the western Cape. SADJ. 2001;56:521-3 pubmed
    ..There is an urgent necessity for oral health to be given a greater priority within the district health system to improve access to integrated oral health care services with appropriate preventive and treatment measures. ..
  33. Fristad I, Bårdsen A, Knudsen G, Molven O. Prodromal herpes zoster--a diagnostic challenge in endodontics. Int Endod J. 2002;35:1012-6 pubmed
    ..Symptoms combined with inadequate technical standard of root fillings may confuse the diagnostics. * No available data support or suggest the use of antiviral treatment as a diagnostic tool. ..
  34. Pau A, Croucher R, Marcenes W. Prevalence estimates and associated factors for dental pain: a review. Oral Health Prev Dent. 2003;1:209-20 pubmed
    ..The prevalence estimates for 5 case definitions identified were: 'toothache' 7-32%, 'pain in teeth with hot, cold or sweet things' 25-38%, 'pain and discomfort needing medication or ..
  35. Turp J. [Atypical odontalgia - a little known phantom pain]. Schmerz. 2001;15:59-64 pubmed
    ..It is to be hoped that the suggested classification will stimulate reflection on these enigmatic orofacial pain disorders. ..
  36. Riley J, Gilbert G, Heft M. Socioeconomic and demographic disparities in symptoms of orofacial pain. J Public Health Dent. 2003;63:166-73 pubmed
    ..Consistent with findings for other subjective measures of oral health, persons of lower SES are at increased risk for orofacial pain and pain-related behavioral impact. ..
  37. Honkala E, Honkala S, Rimpela A, Rimpela M. The trend and risk factors of perceived toothache among Finnish adolescents from 1977 to 1997. J Dent Res. 2001;80:1823-7 pubmed
    b>Toothache is a subjective oral health indicator that should become uncommon when oral health is improving. The aim of this study was to assess changes in perceived toothache between 1977 and 1997 among Finnish adolescents...
  38. Riley J, Gilbert G, Heft M. Orofacial pain symptom prevalence: selective sex differences in the elderly?. Pain. 1998;76:97-104 pubmed
    ..Our findings for prevalence of each specific symptom (jaw joint pain, 7.7%; face pain, 6.9%; oral sores, 6.4%; toothache, 12.0%; burning mouth, 1...
  39. Jantsch H, Kemppainen P, Ringler R, Handwerker H, Forster C. Cortical representation of experimental tooth pain in humans. Pain. 2005;118:390-9 pubmed
  40. Slade G. Epidemiology of dental pain and dental caries among children and adolescents. Community Dent Health. 2001;18:219-27 pubmed
    ..computing correlation coefficients between community-level caries experience (dmft and DMFT) and prevalence of toothache in those communities...
  41. Needleman I, McGrath C, Floyd P, Biddle A. Impact of oral health on the life quality of periodontal patients. J Clin Periodontol. 2004;31:454-7 pubmed
    ..01), "drifting teeth" (p<0.01), "bad breath" (p<0.01) and "toothache" (p<0.01)...
  42. Ng S, Leung W. Oral health-related quality of life and periodontal status. Community Dent Oral Epidemiol. 2006;34:114-22 pubmed
    ..This study demonstrates a significant association between oral health-related QoL and periodontal disease. ..
  43. Bowles W, Withrow J, Lepinski A, Hargreaves K. Tissue levels of immunoreactive substance P are increased in patients with irreversible pulpitis. J Endod. 2003;29:265-7 pubmed
    ..7 +/- 34.0 pM versus 18.2 +/- 6.2 pM). These observations suggest that biochemical measures of inflammatory mediators exhibit significant change during irreversible pulpitis and may contribute to clinical signs and symptoms. ..
  44. Melis M, Lobo S, Ceneviz C, Zawawi K, Al Badawi E, Maloney G, et al. Atypical odontalgia: a review of the literature. Headache. 2003;43:1060-74 pubmed
    ..Atypical odontalgia is surprisingly common, of uncertain origin, and potentially treatable. ..
  45. Gherunpong S, Tsakos G, Sheiham A. The prevalence and severity of oral impacts on daily performances in Thai primary school children. Health Qual Life Outcomes. 2004;2:57 pubmed
    ..The main clinical causes of impacts were sensitive tooth (27.9%), oral ulcers (25.8%), toothache (25.1%) and an exfoliating primary tooth (23.4%)...
  46. Okunseri C, Hodges J, Born D. Self-reported toothache experience in an adult population in Benin City, Edo State, Nigeria. Oral Health Prev Dent. 2005;3:119-25 pubmed
    This pilot study was conducted to estimate the prevalence of self-reported toothache, bleeding gums and oral ulcer experiences, reasons for dental visits and associated sociodemographic factors among adults living in Benin City, Edo ..
  47. Park C, Kim M, Fang Z, Li H, Jung S, Choi S, et al. Functional expression of thermo-transient receptor potential channels in dental primary afferent neurons: implication for tooth pain. J Biol Chem. 2006;281:17304-11 pubmed
    ..Accordingly, blockade of thermo-TRP channels will provide a novel therapeutic intervention for the treatment of tooth pain. ..
  48. Henry M, Hargreaves K. Peripheral mechanisms of odontogenic pain. Dent Clin North Am. 2007;51:19-44, v pubmed
    ..Although many of these pain mechanisms apply throughout the body, we attempt to describe these mechanisms in the context of trigeminal pain. ..
  49. Vickers E, Cousins M. Neuropathic orofacial pain part 1--prevalence and pathophysiology. Aust Endod J. 2000;26:19-26 pubmed
  50. Nomura L, Bastos J, Peres M. Dental pain prevalence and association with dental caries and socioeconomic status in schoolchildren, Southern Brazil, 2002. Braz Oral Res. 2004;18:134-40 pubmed
    ..2-8.4, p = 0.02) more chances of having dental pain when compared with the ones whose families had higher income. High levels of caries attack, low mother schooling level and low family income were associated to dental pain. ..
  51. List T, Leijon G, Helkimo M, Oster A, Svensson P. Effect of local anesthesia on atypical odontalgia--a randomized controlled trial. Pain. 2006;122:306-14 pubmed
    ..The findings indicate that the spontaneous pain in AO patients only to some extent is dependent on peripheral afferent inputs and that sensitization of higher order neurons may be involved in the pathophysiology of AO. ..
  52. Baad Hansen L, Juhl G, Jensen T, Brandsborg B, Svensson P. Differential effect of intravenous S-ketamine and fentanyl on atypical odontalgia and capsaicin-evoked pain. Pain. 2007;129:46-54 pubmed
    ..Furthermore, in contrast to studies on various neuropathic pain conditions, fentanyl and S-ketamine in the present doses failed to attenuate AO pain. ..
  53. Woda A, Pionchon P. [Orofacial idiopathic pain: clinical signs, causes and mechanisms]. Rev Neurol (Paris). 2001;157:265-83 pubmed
    ..Indeed, each of these mechanisms can be observed in all types of orofacial idiopathic pain. This leads to the hypothesis that these different mechanisms may act on each target tissue but the details of interaction are still unknown. ..
  54. Chidchuangchai W, Vongsavan N, Matthews B. Sensory transduction mechanisms responsible for pain caused by cold stimulation of dentine in man. Arch Oral Biol. 2007;52:154-60 pubmed
    ..Separate in vitro observations were made on the effects of these procedures on fluid flow through the dentine...
  55. Hashash J, Atweh L, Saliba T, Chakhachiro Z, Al Kutoubi A, Tawil A, et al. Acute NSAID-related transmural duodenitis and extensive duodenal ulceration. Clin Ther. 2007;29:2448-52 pubmed
    ..We report a patient who developed symptomatic severe transmural duodenitis and periduodenal mesenteric streaking, consistent with a complicated ulcer, probably associated with very short-term exposure to tiaprofenic acid. ..
  56. Fowler S, Fullmer S, Drum M, Reader A. Does acetaminophen/hydrocodone affect cold pulpal testing in patients with symptomatic irreversible pulpitis? A prospective, randomized, double-blind, placebo-controlled study. J Endod. 2014;40:1958-60 pubmed publisher
    ..Patients experienced moderate to severe pain and reactions to cold testing. ..
  57. Gernhofer K. Corticosteroid treatment for symptoms associated with infraorbital nerve dysesthesia/paresthesia. J Mich Dent Assoc. 2008;90:40, 42-4 pubmed
  58. Xia B, Wang C, Ge L. Factors associated with dental behaviour management problems in children aged 2-8 years in Beijing, China. Int J Paediatr Dent. 2011;21:200-9 pubmed publisher
    ..expectations of the child's behaviour during treatment, anxiety or shyness around strangers, and presence of toothache. Children aged 2.5-3.5 years who attended kindergarten showed better dental behaviour than those who did not...
  59. Pattussi M, Peres K, Boing A, Peres M, da Costa J. Self-rated oral health and associated factors in Brazilian elders. Community Dent Oral Epidemiol. 2010;38:348-59 pubmed publisher
    ..Assessment and understanding of self-rated oral health should take into account social factors, subjective and clinical oral symptoms. ..
  60. Horton S, Barker J. Rural Mexican immigrant parents' interpretation of children's dental symptoms and decisions to seek treatment. Community Dent Health. 2009;26:216-21 pubmed
  61. Al Omari Q, Al Omari W, Omar R. Factors associated with postoperative sensitivity of amalgam restorations. J Ir Dent Assoc. 2009;55:87-91 pubmed
    ..Regression analysis suggested that younger patients, females, and pre-operative sensitivity to cold might be predictive of postoperative sensitivity following placement of amalgam restorations. ..
  62. Shidara E, McGlothlin J, Kobayashi S. A vicious cycle in the oral health status of schoolchildren in a primary school in rural Cambodia. Int J Dent Hyg. 2007;5:165-73 pubmed
    ..Ultimately, this poor oral healthcare impacts an individual's quality of life and can lead to more serious health issues later in life. ..
  63. Jürgensen N, Petersen P. Oral health behaviour of urban and semi-urban schoolchildren in the Lao PDR. Community Dent Health. 2011;28:280-5 pubmed
    ..69% of the children reported toothache during the previous 12 months and 38% reported school absenteeism due to toothache...
  64. Riley J, Gibson E, Zsembik B, Duncan R, Gilbert G, Heft M. Acculturation and orofacial pain among Hispanic adults. J Pain. 2008;9:750-8 pubmed publisher
    ..This emphasizes the need to provide Hispanic patients with information in Spanish and the importance of having bilingual materials and staff in dental clinics. ..
  65. Xia B, Wang C, Zhang S. [Confirmatory study on the regression equation for children dental behavior in Beijing]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2013;48:726-9 pubmed
    ..Younger age, negative guardian expectations of the child's behavior during treatment, anxiety or shyness around strangers, and presence of toothache were four risk factors for children's dental BMP.
  66. Batista M, Perianes L, Hilgert J, Hugo F, Sousa M. The impacts of oral health on quality of life in working adults. Braz Oral Res. 2014;28: pubmed
    ..32) were most likely to impact OHRQoL. Therefore, socioeconomic and demographic status and use of dental services impacted OHRQoL. These results indicate that oral health promotion strategies should be included in work environments. ..
  67. Weinberg M, Gopinathan G. Recognition and treatment of migraine patient in dental practice. N Y State Dent J. 2009;75:28-33 pubmed
    ..Temporomandibular joint disorders, toothache, jaw and sinus pain often coexist with headaches...