Summary: Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.

Top Publications

  1. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
  2. ncbi International physical activity questionnaire: 12-country reliability and validity
    Cora L Craig
    Canadian Fitness and Lifestyle Research Institute, Ottawa, Canada
    Med Sci Sports Exerc 35:1381-95. 2003
  3. ncbi Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:1343-50. 2001
  4. ncbi Compendium of physical activities: an update of activity codes and MET intensities
    B E Ainsworth
    Department of Epidemiology and Biostatistics, School of Public Health, University of South Carolina, Columbia 29208, USA
    Med Sci Sports Exerc 32:S498-504. 2000
  5. pmc Health benefits of physical activity: the evidence
    Darren E R Warburton
    School of Human Kinetics, University of British Columbia, and the Healthy Heart Program, St Paul s Hospital, Vancouver, BC
    CMAJ 174:801-9. 2006
  6. ncbi Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association
    William L Haskell
    Stanford University School of Medicine, Stanford, CA 94305 5705, USA
    Med Sci Sports Exerc 39:1423-34. 2007
  7. ncbi Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association
    William L Haskell
    Stanford University, USA
    Circulation 116:1081-93. 2007
  8. ncbi Obesity in children and young people: a crisis in public health
    T Lobstein
    IASO International Obesity TaskForce, 231 North Gower Street, London NW1 2NS, UK
    Obes Rev 5:4-104. 2004
  9. ncbi Effective techniques in healthy eating and physical activity interventions: a meta-regression
    Susan Michie
    Centre for Outcomes Research and Effectiveness, University College London, UK
    Health Psychol 28:690-701. 2009
  10. ncbi Calibration of two objective measures of physical activity for children
    Kelly R Evenson
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill 27514 USA
    J Sports Sci 26:1557-65. 2008

Detail Information

Publications322 found, 100 shown here

  1. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
    ..We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes...
  2. ncbi International physical activity questionnaire: 12-country reliability and validity
    Cora L Craig
    Canadian Fitness and Lifestyle Research Institute, Ottawa, Canada
    Med Sci Sports Exerc 35:1381-95. 2003
    ..The International Physical Activity Questionnaire (IPAQ) was developed as an instrument for cross-national monitoring of physical activity and inactivity...
  3. ncbi Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:1343-50. 2001
    ..Whether type 2 diabetes can be prevented by interventions that affect the lifestyles of subjects at high risk for the disease is not known...
  4. ncbi Compendium of physical activities: an update of activity codes and MET intensities
    B E Ainsworth
    Department of Epidemiology and Biostatistics, School of Public Health, University of South Carolina, Columbia 29208, USA
    Med Sci Sports Exerc 32:S498-504. 2000
    ..The updated version includes two new major headings of volunteer and religious activities, extends the number of specific activities from 477 to 605, and provides updated MET intensity levels for selected activities...
  5. pmc Health benefits of physical activity: the evidence
    Darren E R Warburton
    School of Human Kinetics, University of British Columbia, and the Healthy Heart Program, St Paul s Hospital, Vancouver, BC
    CMAJ 174:801-9. 2006
    ..There appears to be a linear relation between physical activity and health status, such that a further increase in physical activity and fitness will lead to additional improvements in health status...
  6. ncbi Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association
    William L Haskell
    Stanford University School of Medicine, Stanford, CA 94305 5705, USA
    Med Sci Sports Exerc 39:1423-34. 2007
    ..The Committee on Exercise and Cardiac Rehabilitation of the American Heart Association endorsed and supported these recommendations...
  7. ncbi Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association
    William L Haskell
    Stanford University, USA
    Circulation 116:1081-93. 2007
    ..The Committee on Exercise and Cardiac Rehabilitation of the American Heart Association endorsed and supported these recommendations...
  8. ncbi Obesity in children and young people: a crisis in public health
    T Lobstein
    IASO International Obesity TaskForce, 231 North Gower Street, London NW1 2NS, UK
    Obes Rev 5:4-104. 2004
  9. ncbi Effective techniques in healthy eating and physical activity interventions: a meta-regression
    Susan Michie
    Centre for Outcomes Research and Effectiveness, University College London, UK
    Health Psychol 28:690-701. 2009
    ..This study aimed to assess the effectiveness of active BC interventions designed to promote physical activity and healthy eating and investigate whether theoretically specified BC techniques improve outcome...
  10. ncbi Calibration of two objective measures of physical activity for children
    Kelly R Evenson
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill 27514 USA
    J Sports Sci 26:1557-65. 2008
    ..This calibration study, using indirect calorimetry, suggests that the two accelerometers can be used to distinguish differing levels of physical activity intensity as well as inactivity among children 5 to 8 years of age...
  11. ncbi An ecological approach to creating active living communities
    James F Sallis
    Department of Psychology, San Diego State University, San Diego, California 92103, USA
    Annu Rev Public Health 27:297-322. 2006
    ..Collaborations with policy researchers may improve the likelihood of translating research findings into changes in environments, policies, and practices...
  12. ncbi A review of correlates of physical activity of children and adolescents
    J F Sallis
    Joint Doctoral Program in Clinical Psychology, San Diego State University University of California, 92120, USA
    Med Sci Sports Exerc 32:963-75. 2000
    ..Understanding the factors that influence physical activity can aid the design of more effective interventions. Previous reviews of correlates of youth physical activity have produced conflicting results...
  13. ncbi Fitness effects on the cognitive function of older adults: a meta-analytic study
    Stanley Colcombe
    Beckman Institute and Department of Psychology, University of Illinois, Urbana, 61801, USA
    Psychol Sci 14:125-30. 2003
    ..The results are discussed in terms of recent neuroscientific and psychological data that indicate cognitive and neural plasticity is maintained throughout the life span...
  14. ncbi Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease
    Marc T Hamilton
    Department of Biomedical Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Diabetes 56:2655-67. 2007
    ..have reached the historical pinnacle of physical inactivity, even in cohorts where people already do not perform exercise. Our purpose here is to examine the role of sedentary behaviors, especially sitting, on mortality, cardiovascular ..
  15. ncbi The anti-inflammatory effect of exercise
    Anne Marie W Petersen
    Dept of Infectious Diseases, Rigshospitalet, Section 7641, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    J Appl Physiol 98:1154-62. 2005
    Regular exercise offers protection against all-cause mortality, primarily by protection against cardiovascular disease and Type 2 diabetes mellitus...
  16. ncbi Muscles, exercise and obesity: skeletal muscle as a secretory organ
    Bente K Pedersen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Rigshospitalet, Section 7641, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Nat Rev Endocrinol 8:457-65. 2012
  17. pmc Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy
    I Min Lee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Lancet 380:219-29. 2012
  18. pmc Amount of time spent in sedentary behaviors and cause-specific mortality in US adults
    Charles E Matthews
    Nutritional Epidemiology Branch, National Cancer Institute, Rockville, MD, USA
    Am J Clin Nutr 95:437-45. 2012
    ..Sedentary behaviors predominate modern life, yet we do not fully understand the adverse effects of these behaviors on mortality after considering the benefits of moderate-vigorous physical activity (MVPA)...
  19. pmc Exercise training increases size of hippocampus and improves memory
    Kirk I Erickson
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Proc Natl Acad Sci U S A 108:3017-22. 2011
    ..adults, and physical activity training increases hippocampal perfusion, but the extent to which aerobic exercise training can modify hippocampal volume in late adulthood remains unknown...
  20. ncbi Diet, lifestyle, and the risk of type 2 diabetes mellitus in women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 345:790-7. 2001
    ..Previous studies have examined individual dietary and lifestyle factors in relation to type 2 diabetes, but the combined effects of these factors are largely unknown...
  21. ncbi Effective exercise for the prevention of falls: a systematic review and meta-analysis
    Catherine Sherrington
    Musculoskeletal Division, The George Institute for International Health, University of Sydney, Sydney, Australia
    J Am Geriatr Soc 56:2234-43. 2008
    To determine the effects of exercise on falls prevention in older people and establish whether particular trial characteristics or components of exercise programs are associated with larger reductions in falls.
  22. pmc Neighborhood-based differences in physical activity: an environment scale evaluation
    Brian E Saelens
    Division of Psychology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, MLC 3015, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Am J Public Health 93:1552-8. 2003
    ..This study evaluated a neighborhood environment survey and compared the physical activity and weight status of the residents in 2 neighborhoods...
  23. ncbi Position statement. Part one: Immune function and exercise
    Neil P Walsh
    School of Sport, Health and Exercise Sciences, Bangor University, UK
    Exerc Immunol Rev 17:6-63. 2011
    ..volume of peer-reviewed publications speaks to the recent and rapid growth in both scope and understanding of exercise immunology...
  24. ncbi A brief review on correlates of physical activity and sedentariness in youth
    Klazine van der Horst
    EMGO Institute, Department of Public and Occupational Health, VU University Medical Center, Amsterdam, The Netherlands
    Med Sci Sports Exerc 39:1241-50. 2007
    ..The main goal of this systematic review is to summarize and update the existing literature on correlates of young people's physical activity, insufficient physical activity, and sedentary behavior...
  25. pmc FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise
    Joo Young Huh
    Division of Endocrinology, Diabetes, and Metabolism, BethIsrael Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Metabolism 61:1725-38. 2012
    ..prior study has shown that FNDC5 induces browning of subcutaneous fat in mice and mediates beneficial effects of exercise on metabolism, but a more recent study using gene expression arrays failed to detect a robust increase in FNDC5 ..
  26. ncbi Reproducibility and relative validity of the short questionnaire to assess health-enhancing physical activity
    G C Wanda Wendel-Vos
    Department for Chronic Diseases Epidemiology, National Institute for Public Health and the Environment, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    J Clin Epidemiol 56:1163-9. 2003
    ..The purpose of this study is to determine reproducibility and relative validity of the Short QUestionnaire to ASsess Health-enhancing physical activity (SQUASH)...
  27. ncbi Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 289:1785-91. 2003
    Current public health campaigns to reduce obesity and type 2 diabetes have largely focused on increasing exercise, but have paid little attention to the reduction of sedentary behaviors.
  28. ncbi Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study
    Chi Pang Wen
    Institute of Population Science, National Health Research Institutes, Zhunan, Taiwan
    Lancet 378:1244-53. 2011
    The health benefits of leisure-time physical activity are well known, but whether less exercise than the recommended 150 min a week can have life expectancy benefits is unclear...
  29. ncbi Moderate-to-vigorous physical activity from ages 9 to 15 years
    Philip R Nader
    Department of Pediatrics, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0927, USA
    JAMA 300:295-305. 2008
    ..Although at least 60 minutes per day of moderate-to-vigorous physical activity (MVPA) is recommended, few longitudinal studies have determined the recent patterns of physical activity of youth...
  30. ncbi Muscle as an endocrine organ: focus on muscle-derived interleukin-6
    Bente K Pedersen
    The Centre of Inflammation and Metabolism at Department of Infectious Diseases, Rigshospitalet, The Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Physiol Rev 88:1379-406. 2008
    ..as a myokine because of the observation that it increases up to 100-fold in the circulation during physical exercise. Identification of IL-6 production by skeletal muscle during physical activity generated renewed interest in the ..
  31. ncbi Be smart, exercise your heart: exercise effects on brain and cognition
    Charles H Hillman
    Charles H Hillman is at the Department of Kinesiology and Community Health, 213 Louise Freer Hall, 906 South Goodwin Avenue, University of Illinois, Urbana, Illinois 61801, USA
    Nat Rev Neurosci 9:58-65. 2008
    ..literature has documented the beneficial influence of physical activity engendered through aerobic exercise on selective aspects of brain function...
  32. pmc Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
    Physiol Rev 88:1243-76. 2008
    The first suggestion that physical exercise results in free radical-mediated damage to tissues appeared in 1978, and the past three decades have resulted in a large growth of knowledge regarding exercise and oxidative stress...
  33. ncbi Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
    Nicholas J Wareham
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Robinson Way, CB2 2SR, UK
    Public Health Nutr 6:407-13. 2003
  34. ncbi Spinal and supraspinal factors in human muscle fatigue
    S C Gandevia
    Prince of Wales Medical Research Institute, Prince of Wales Hospital and University of New South Wales, Randwick, Sydney, Australia
    Physiol Rev 81:1725-89. 2001
    Muscle fatigue is an exercise-induced reduction in maximal voluntary muscle force...
  35. ncbi Objectively measured sedentary time, physical activity, and metabolic risk: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab)
    Genevieve N Healy
    School of Population Health, University of Queensland, Brisbane, Australia
    Diabetes Care 31:369-71. 2008
    ..We examined the associations of objectively measured sedentary time and physical activity with continuous indexes of metabolic risk in Australian adults without known diabetes...
  36. ncbi Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes: a systematic review and meta-analysis
    Daniel Umpierre
    Exercise Pathophysiology Research Laboratory, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    JAMA 305:1790-9. 2011
    Regular exercise improves glucose control in diabetes, but the association of different exercise training interventions on glucose control is unclear.
  37. ncbi Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association
    Miriam E Nelson
    John Hancock Center for Physical Activity and Nutrition, Tufts University, Boston, MA, USA
    Med Sci Sports Exerc 39:1435-45. 2007
    ..To issue a recommendation on the types and amounts of physical activity needed to improve and maintain health in older adults...
  38. ncbi Using pedometers to increase physical activity and improve health: a systematic review
    Dena M Bravata
    Center for Primary Care and Outcomes Research, Stanford University, Stanford, California, USA
    JAMA 298:2296-304. 2007
    ..Without detailed evidence of their effectiveness, pedometers have recently become popular as a tool for motivating physical activity...
  39. ncbi Physical activity from childhood to adulthood: a 21-year tracking study
    Risto Telama
    LIKES Research Center, Keltavuokko 4C, 40520 Jyväskylä, Finland
    Am J Prev Med 28:267-73. 2005
  40. ncbi Aerobic exercise training increases brain volume in aging humans
    Stanley J Colcombe
    Beckman Institute, Department of Psychology, University of Illinois, 405 N Mathews Ave, Urbana, IL 61801, USA
    J Gerontol A Biol Sci Med Sci 61:1166-70. 2006
    ..The present study examined whether aerobic fitness training of older humans can increase brain volume in regions associated with age-related decline in both brain structure and cognition...
  41. ncbi What proportion of youth are physically active? Measurement issues, levels and recent time trends
    Ulf Ekelund
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrookes Hospital, Box 285, Cambridge CB2 0QQ, UK
    Br J Sports Med 45:859-65. 2011
    ..Current levels and temporal trends in PA and sport participation and the effect of assessment method on data interpretation will be summarised...
  42. pmc Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise
    K Stenlof
    Clinical Trial Center, Sahlgrenska University Hospital, Gothenburg, Sweden
    Diabetes Obes Metab 15:372-82. 2013
    Canagliflozin is a sodium glucose co-transporter 2 inhibitor in development for type 2 diabetes mellitus (T2DM). The efficacy and safety of canagliflozin were evaluated in subjects with T2DM inadequately controlled with diet and exercise.
  43. ncbi Understanding environmental influences on walking; Review and research agenda
    Neville Owen
    Cancer Prevention Research Centre, School of Population Health, University of Queensland, Brisbane, Queensland, Australia
    Am J Prev Med 27:67-76. 2004
    ..Walking is the most common physical activity behavior of adults; environmental innovations may be able to influence rates of participation...
  44. ncbi Comparison of overweight and obesity prevalence in school-aged youth from 34 countries and their relationships with physical activity and dietary patterns
    I Janssen
    Department of Community Health and Epidemiology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Obes Rev 6:123-32. 2005
    ..Increasing physical activity participation and decreasing television viewing should be the focus of strategies aimed at preventing and treating overweight and obesity in youth...
  45. ncbi Acute exercise remodels promoter methylation in human skeletal muscle
    Romain Barres
    Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Cell Metab 15:405-11. 2012
    DNA methylation is a covalent biochemical modification controlling chromatin structure and gene expression. Exercise elicits gene expression changes that trigger structural and metabolic adaptations in skeletal muscle...
  46. ncbi The International Physical Activity Questionnaire (IPAQ): a study of concurrent and construct validity
    Maria Hagstromer
    Unit for Preventive Nutrition Novum, Department of Biosciences, Karolinska Institutet, S 141 57 Huddinge, Sweden
    Public Health Nutr 9:755-62. 2006
    ..The short version of the IPAQ has been tested extensively and is now used in many international studies. The present study aimed to explore the validity characteristics of the long-version IPAQ...
  47. pmc Antioxidants prevent health-promoting effects of physical exercise in humans
    Michael Ristow
    Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena D 07743, Germany
    Proc Natl Acad Sci U S A 106:8665-70. 2009
    b>Exercise promotes longevity and ameliorates type 2 diabetes mellitus and insulin resistance. However, exercise also increases mitochondrial formation of presumably harmful reactive oxygen species (ROS)...
  48. ncbi Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
    Salim Yusuf
    Population Health Research Institute, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    Lancet 364:937-52. 2004
    ..Therefore, the effect of such factors on risk of coronary heart disease in most regions of the world is unknown...
  49. ncbi Neighborhood environment and physical activity among youth a review
    Ding Ding
    Graduate School of Public Health, San Diego State University, California, USA
    Am J Prev Med 41:442-55. 2011
    ..An updated review of literature is needed to summarize the current evidence base, and to inform policies and environmental interventions to promote active lifestyles among young people...
  50. pmc The role of exercise and PGC1alpha in inflammation and chronic disease
    Christoph Handschin
    Institute of Physiology and Zurich Center for Integrative Human Physiology ZIHP, University of Zurich, CH 8057 Zurich, Switzerland
    Nature 454:463-9. 2008
    ..The transcriptional coactivator PGC1alpha has recently been shown to regulate several exercise-associated aspects of muscle function...
  51. pmc Cardiovascular fitness, cortical plasticity, and aging
    Stanley J Colcombe
    The Beckman Institute, and Neuroscience Program, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 101:3316-21. 2004
    ..These data suggest that increased cardiovascular fitness can affect improvements in the plasticity of the aging human brain, and may serve to reduce both biological and cognitive senescence in humans...
  52. pmc Agreement between activPAL and ActiGraph for assessing children's sedentary time
    Nicola D Ridgers
    Centre for Physical Activity and Nutrition Research, Deakin University, 221 Burwood Hwy, Burwood 3125 Melbourne, Australia
    Int J Behav Nutr Phys Act 9:15. 2012
  53. pmc Leisure time spent sitting in relation to total mortality in a prospective cohort of US adults
    Alpa V Patel
    Epidemiology Research Program, American Cancer Society, 250 Williams Street NW, Atlanta, GA 30303, USA
    Am J Epidemiol 172:419-29. 2010
    ..The time spent sitting was independently associated with total mortality, regardless of physical activity level. Public health messages should include both being physically active and reducing time spent sitting...
  54. ncbi An update of controlled physical activity trials in cancer survivors: a systematic review and meta-analysis
    Rebecca M Speck
    Division of Clinical Epidemiology, University of Pennsylvania, Philadelphia, PA, USA
    J Cancer Surviv 4:87-100. 2010
    ..Activity prescriptions for cancer survivors rely on evidence as to whether exercise during or after treatment results in improved health outcomes...
  55. ncbi Potential environmental determinants of physical activity in adults: a systematic review
    W Wendel-Vos
    Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Obes Rev 8:425-40. 2007
    ..However, most studies used cross-sectional designs and non-validated measures of environments and/or behaviour. Therefore, no strong conclusions can be drawn and more research of better quality is clearly needed...
  56. ncbi Weight-loss outcomes: a systematic review and meta-analysis of weight-loss clinical trials with a minimum 1-year follow-up
    Marion J Franz
    Nutrition Concepts by Franz, Inc, Minneapolis, MN 55439, USA
    J Am Diet Assoc 107:1755-67. 2007
  57. pmc Effect of school-based interventions on physical activity and fitness in children and adolescents: a review of reviews and systematic update
    S Kriemler
    Swiss Tropical and Public Health Institute, University of Basel, Socinstr 59, 4002 Basel, Switzerland
    Br J Sports Med 45:923-30. 2011
    ..School-based interventions are thought to be the most universally applicable and effective way to counteract low physical activity (PA) and fitness although there is controversy about the optimal strategy to intervene...
  58. pmc Limits to the measurement of habitual physical activity by questionnaires
    R J Shephard
    Br J Sports Med 37:197-206; discussion 206. 2003
    ..However, attempts at detailed interpretation in terms of exercise dosage and the extent of resulting health benefits seem premature...
  59. ncbi Environmental contributions to the obesity epidemic
    J O Hill
    Colorado Clinical Nutrition Research Unit, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Science 280:1371-4. 1998
    ..Because obesity is difficult to treat, public health efforts need to be directed toward prevention...
  60. ncbi Tracking of sedentary behaviours of young people: a systematic review
    Stuart J H Biddle
    School of Sport, Exercise and Health Sciences, Loughborough University, UK
    Prev Med 51:345-51. 2010
    ..To review the empirical evidence concerning the strength of tracking of sedentary behaviours from childhood and adolescence...
  61. ncbi Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial
    Lawrence J Appel
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Md 21205 2233, USA
    JAMA 289:2083-93. 2003
    ..The Dietary Approaches to Stop Hypertension (DASH) diet also lowers BP. To date, no trial has evaluated the effects of simultaneously implementing these lifestyle recommendations...
  62. pmc Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans
    Kirsten A Burgomaster
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    J Physiol 586:151-60. 2008
    ..reached following traditional endurance training (ET) but no study has examined metabolic adaptations during exercise after these different training strategies...
  63. ncbi Television viewing time and mortality: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab)
    D W Dunstan
    Baker IDI Heart and Diabetes Institute, 250 Kooyong Rd, Caulfield, Victoria, Australia 3162
    Circulation 121:384-91. 2010
    ..We examined the associations of prolonged television viewing time with all-cause, cardiovascular disease (CVD), cancer, and non-CVD/noncancer mortality in Australian adults...
  64. ncbi Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial
    Nicola T Lautenschlager
    WA Centre for Health and Ageing, University of Western Australia, Melbourne, Australia
    JAMA 300:1027-37. 2008
    ..Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking...
  65. ncbi Physical activity level and health-related quality of life in the general adult population: a systematic review
    Raphael Bize
    Centre for Health Promotion Studies, School of Public Health, University of Alberta, Edmonton, Canada
    Prev Med 45:401-15. 2007
    ..Little is known regarding health-related quality of life and its relation with physical activity level in the general population. Our primary objective was to systematically review data examining this relationship...
  66. ncbi The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease
    Michael Gleeson
    Inflammation, Exercise and Metabolism Research Group, School of Sport, Exercise and Health Sciences, Loughborough University, Ashby Road, Loughborough, Leicestershire LE11 3TU, UK
    Nat Rev Immunol 11:607-15. 2011
    Regular exercise reduces the risk of chronic metabolic and cardiorespiratory diseases, in part because exercise exerts anti-inflammatory effects...
  67. ncbi Physical activity and television watching in relation to risk for type 2 diabetes mellitus in men
    F B Hu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Arch Intern Med 161:1542-8. 2001
    ..Television (TV) watching, a major sedentary behavior in the United States, has been associated with obesity. We hypothesized that prolonged TV watching may increase risk for type 2 diabetes...
  68. ncbi Physical activity and clustered cardiovascular risk in children: a cross-sectional study (The European Youth Heart Study)
    Lars Bo Andersen
    Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway
    Lancet 368:299-304. 2006
    ..This study's aim was to assess the associations of objectively measured physical activity with clustering of cardiovascular disease risk factors in children and derive guidelines on the basis of this analysis...
  69. ncbi The ABC of Physical Activity for Health: a consensus statement from the British Association of Sport and Exercise Sciences
    Gary O'Donovan
    School of Sport and Health Sciences, University of Exeter, Exeter, UK
    J Sports Sci 28:573-91. 2010
    ..Therefore, the British Association of Sport and Exercise Sciences convened a panel of experts to review the literature and produce guidelines that health professionals ..
  70. ncbi Exercise to prevent falls in older adults: an updated meta-analysis and best practice recommendations
    Catherine Sherrington
    Musculoskeletal Division, The George Institute for Global Health, The University of Sydney, Australia
    N S W Public Health Bull 22:78-83. 2011
    This systematic review update includes 54 randomised controlled trials and confirms that exercise as a single intervention can prevent falls (pooled rate ratio 0.84, 95% CI 0.77-0.91)...
  71. ncbi Global physical activity levels: surveillance progress, pitfalls, and prospects
    Pedro C Hallal
    Universidade Federal de Pelotas, Brazil
    Lancet 380:247-57. 2012
    ..Continued improvement in monitoring of physical activity would help to guide development of policies and programmes to increase activity levels and to reduce the burden of non-communicable diseases...
  72. ncbi Systematic review of school-based interventions that focus on changing dietary intake and physical activity levels to prevent childhood obesity: an update to the obesity guidance produced by the National Institute for Health and Clinical Excellence
    T Brown
    School of Health and Social Care, University of Teesside, Middlesbrough, UK
    Obes Rev 10:110-41. 2009
    ..Physical activity interventions, particularly in girls in primary schools, may help to prevent these children from becoming overweight in the short term...
  73. ncbi Objectively measured light-intensity physical activity is independently associated with 2-h plasma glucose
    Genevieve N Healy
    Cancer Prevention Research Centre, School of Population Health, The University of Queensland, Brisbane, Australia
    Diabetes Care 30:1384-9. 2007
    ..We examined the associations of objectively measured sedentary time, light-intensity physical activity, and moderate- to vigorous-intensity activity with fasting and 2-h postchallenge plasma glucose in Australian adults...
  74. ncbi Global nutrition dynamics: the world is shifting rapidly toward a diet linked with noncommunicable diseases
    Barry M Popkin
    University of North Carolina, Chapel Hill, NC, USA
    Am J Clin Nutr 84:289-98. 2006
    ..The challenge to global health is clear...
  75. ncbi Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials
    Rod S Taylor
    Department of Epidemiology and Public Health, University of Birmingham, Birmingham, United Kingdom
    Am J Med 116:682-92. 2004
    To review the effectiveness of exercise-based cardiac rehabilitation in patients with coronary heart disease.
  76. pmc Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men
    Vinod Kumar
    University of Nottingham, School of Graduate Entry Medicine and Health, City Hospital, Uttoxeter Road, Derby, DE22 3DT, UK
    J Physiol 587:211-7. 2009
    ..We investigated how myofibrillar protein synthesis (MPS) and muscle anabolic signalling were affected by resistance exercise at 20-90% of 1 repetition maximum (1 RM) in two groups (25 each) of post-absorptive, healthy, young (24 +/- 6 ..
  77. ncbi Reducing children's television viewing to prevent obesity: a randomized controlled trial
    T N Robinson
    Department of Pediatrics, Stanford Center for Research in Disease Prevention, Stanford University School of Medicine, Palo Alto, Calif 94304, USA
    JAMA 282:1561-7. 1999
    ..Some observational studies have found an association between television viewing and child and adolescent adiposity...
  78. pmc Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults
    Thomas P J Solomon
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave NE 40, Cleveland, OH 44195, USA
    J Appl Physiol (1985) 104:1313-9. 2008
    Older, obese, and sedentary individuals are at high risk of developing diabetes and cardiovascular disease. Exercise training improves metabolic anomalies associated with such diseases, but the effects of caloric restriction in addition ..
  79. pmc Effectiveness of interventions to promote physical activity in children and adolescents: systematic review of controlled trials
    Esther M F van Sluijs
    Medical Research Council Epidemiology Unit, Institute of Metabolic Sciences, Addenbrooke s Hospital, Cambridge CB2 0QQ
    BMJ 335:703. 2007
    ..To review the published literature on the effectiveness of interventions to promote physical activity in children and adolescents...
  80. ncbi Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study
    Ulrik Wisløff
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Olav Kyrres gt 9, 7489 Trondheim, Norway
    Circulation 115:3086-94. 2007
    b>Exercise training reduces the symptoms of chronic heart failure. Which exercise intensity yields maximal beneficial adaptations is controversial...
  81. ncbi Effect of beta-alanine supplementation on muscle carnosine concentrations and exercise performance
    Craig Sale
    School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, UK
    Amino Acids 39:321-33. 2010
    High-intensity exercise results in reduced substrate levels and accumulation of metabolites in the skeletal muscle. The accumulation of these metabolites (e.g...
  82. pmc Test-retest reliability and construct validity of the ENERGY-child questionnaire on energy balance-related behaviours and their potential determinants: the ENERGY-project
    Amika S Singh
    VU University Medical Center, EMGO Institute for Health and Care Research, Dpt, of Public and Occupational Health, Amsterdam, The Netherlands
    Int J Behav Nutr Phys Act 8:136. 2011
    ..Therefore, reliable and valid tools to measure these variables in large-scale population research are needed...
  83. ncbi Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials
    N G Boulé
    Clinical Epidemiology Unit, Ottawa Health Research Institute, 1053 Carling Ave, Ottawa, Ontario, Canada K1Y 4E9
    JAMA 286:1218-27. 2001
    b>Exercise is widely perceived to be beneficial for glycemic control and weight loss in patients with type 2 diabetes...
  84. ncbi Exercise: a behavioral intervention to enhance brain health and plasticity
    Carl W Cotman
    Institute for Brain Aging and Dementia, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4540, USA
    Trends Neurosci 25:295-301. 2002
    Extensive research on humans suggests that exercise could have benefits for overall health and cognitive function, particularly in later life...
  85. pmc The diseasome of physical inactivity--and the role of myokines in muscle--fat cross talk
    Bente K Pedersen
    Centre of Inflammation and Metabolism, Rigshospitalet Section 7641, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    J Physiol 587:5559-68. 2009
    ..Evidence suggests that the protective effect of exercise may to some extent be ascribed to the anti-inflammatory effect of regular exercise, which can be mediated via a ..
  86. ncbi The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review
    Christos Kasapis
    Department of Internal Medicine, University of Connecticut, Farmington, Connecticut, USA
    J Am Coll Cardiol 45:1563-9. 2005
    ..We searched PubMed for articles published between 1975 through May 2004 using the terms exercise, physical activity, or physical fitness combined with C-reactive protein, inflammation, inflammatory markers, or ..
  87. ncbi Exercise, glucose transport, and insulin sensitivity
    L J Goodyear
    Research Division, Joslin Diabetes Center, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Annu Rev Med 49:235-61. 1998
    Physical exercise can be an important adjunct in the treatment of both non-insulin-dependent diabetes mellitus and insulin-dependent diabetes mellitus...
  88. ncbi Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery
    Lars Sjöström
    Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    N Engl J Med 351:2683-93. 2004
    ..Weight loss is associated with short-term amelioration and prevention of metabolic and cardiovascular risk, but whether these benefits persist over time is unknown...
  89. pmc Older adults, chronic disease and leisure-time physical activity
    Maureen C Ashe
    Rehabilitation Research Laboratory, GF Strong Rehabilitation Centre, University of British Columbia, Canada
    Gerontology 55:64-72. 2009
    ..However, there is limited information on current physical activity levels for older adults and even less for those with chronic diseases...
  90. ncbi Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials
    Seamus P Whelton
    Tulane University, New Orleans, Louisiana 70112, USA
    Ann Intern Med 136:493-503. 2002
    ..This meta-analysis of randomized, controlled trials was conducted to determine the effect of aerobic exercise on blood pressure.
  91. pmc Defining accelerometer thresholds for activity intensities in adolescent girls
    Margarita S Treuth
    Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Med Sci Sports Exerc 36:1259-66. 2004
  92. ncbi Sedentary behaviour and obesity development in children and adolescents
    Juan Pablo Rey-López
    HELENA Study Group, School of Health Sciences, University of Zaragoza, Edificio Cervantes, 2nd Floor, C Corona de Aragón 42, 50009 Zaragoza, Spain
    Nutr Metab Cardiovasc Dis 18:242-51. 2008
    ..Mechanisms that explain the link between sedentariness and obesity are also discussed. Finally, future studies should take into account important mediators such as socioeconomic status and family structure...
  93. ncbi European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by r
    Ian Graham
    Department of Cardiology, Adelaide and Meath Hospital, Dublin, Ireland
    Eur Heart J 28:2375-414. 2007
  94. ncbi Moderate exercise is an antioxidant: upregulation of antioxidant genes by training
    Mari Carmen Gomez-Cabrera
    Department of Physiology, Faculty of Medicine, University of Valencia, Blasco Ibañez, 15, 46010 Valencia, Spain
    Free Radic Biol Med 44:126-31. 2008
    b>Exercise causes oxidative stress only when exhaustive. Strenuous exercise causes oxidation of glutathione, release of cytosolic enzymes, and other signs of cell damage...
  95. ncbi Effects of exercise programs to prevent decline in health-related quality of life in highly deconditioned institutionalized elderly persons: a randomized controlled trial
    Arnaud Dechamps
    Department of Physical Activity and Exercise Psychology, LACES 4140, Faculte des Sciences du Sport, Bordeaux, France
    Arch Intern Med 170:162-9. 2010
    Our objective was to assess the effects of targeted exercise programs on health-related quality of life compared with usual care based on the ability to perform activities of daily living (ADL) and the Neuropsychiatric Inventory scores in ..
  96. ncbi Using self-determination theory to promote physical activity and weight control: a randomized controlled trial in women
    Marlene N Silva
    Faculty of Human Kinetics, Technical University of Lisbon, Estrada da Costa, Cruz Quebrada, 1495 688, Lisbon, Portugal
    J Behav Med 33:110-22. 2010
    ..intervention based on self-determination theory (SDT) on theory-based psychosocial mediators, physical activity/exercise, and body weight and composition. Participants were 239 women (37.6 +/- 7.1 years; 31.5 +/- 4...
  97. pmc Is housework good for health? Levels of physical activity and factors associated with activity in elderly women. Results from the British Women's Heart and Health Study
    D A Lawlor
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Epidemiol Community Health 56:473-8. 2002
    ..To determine the prevalence of achieving new recommended levels of physical activity, the types of activity involved, and their determinants among elderly British women...
  98. pmc Gene X environment interaction of vigorous exercise and body mass index among male Vietnam-era twins
    Jeanne M McCaffery
    Weight Control and Diabetes Research Center, Brown Medical School and The Miriam Hospital, Providence, RI 02903, USA
    Am J Clin Nutr 89:1011-8. 2009
    ..However, twin models that incorporate a gene-environment correlation and gene x environment interaction have not been applied to elucidate specific environmental factors that affect the heritability of BMI...
  99. ncbi Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn, USA
    JAMA 289:323-30. 2003
    ..The increasing prevalence of obesity is a major public health concern. Physical activity may promote weight and body fat loss...
  100. ncbi Exercise builds brain health: key roles of growth factor cascades and inflammation
    Carl W Cotman
    University of California, Irvine Institute for Brain Aging and Dementia, 1113 Gillespie Building, Irvine, CA 92617 4540, USA
    Trends Neurosci 30:464-72. 2007
    Human and other animal studies demonstrate that exercise targets many aspects of brain function and has broad effects on overall brain health...
  101. pmc Interventions to promote walking: systematic review
    David Ogilvie
    Medical Research Council Social and Public Health Sciences Unit, Glasgow G12 8RZ
    BMJ 334:1204. 2007
    ..To assess the effects of interventions to promote walking in individuals and populations...

Research Grants82

  1. Integrative Cardiovascular Control During Exercise in Hypertension
    DONAL S O apos LEARY; Fiscal Year: 2010
    ..Although the beneficial effects of daily exercise are well known, in patients with established hypertension abnormally large increases in sympathetic nerve ..
    Thomas A Platts Mills; Fiscal Year: 2010
    ..The participants will complete an exercise protocol with lung function and will be assessed for evidence of inflammation and allergic sensitization...
  3. Exercise training and blood pressure in hypertension: integrated mechanisms
    Noreen F Rossi; Fiscal Year: 2012
    ..Thus, it is important to seek alternative or adjunctive strategies. Regular exercise is a mainstay of rehabilitative strategies and is key to cardiovascular health...
  4. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012
    ..Resistance training (RT) is an important type of exercise that has been shown to induce positive physiological adaptations such as increasing lean mass and reducing ..
  5. Comparative Resistance Exercise Effects on Knee Osteoarthritis Pain, Functional I
    KEVIN ROBERT VINCENT; Fiscal Year: 2013
    ..The proposed investigation will be the first to rigorously evaluate the influence of two modes of resistance exercise (RX) on knee OA pain and functional impairment...
  6. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
    ..4) Evaluate combinations of exercise or CR-mimetic drugs with mADF, to assess amplification of beneficial effects...
  7. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
    ..They are viable and fertile, but have marked exercise intolerance, reduced collagen fibril diameter in tendons, and overly compliant great vessels of the heart...
  8. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..As a result there will be multiple repercussions to their defects or failures. It can be anticipated, therefore, that our research will have consequences outside its field of muscle and exercise.
  9. Weight Loss &Exercise Effects on Telomere Length in Postmenopausal Women
    ANNE M MCTIERNAN; Fiscal Year: 2012
    ..shortening, but there is a lack of research on 1) the independent and combined effects of dietary weight loss and exercise on telomere length and 2) the amount of weight loss, or change in body composition that may be necessary to ..
  10. Remote-control mouse-implantable micropumps for establishment of regenerative cap
    JUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010
    ..These profiles will be automatically synchronized with mouse behaviors including exercise and sleep in the case of candidate MuSC regulators that are naturally synchronized with these behaviors, such as ..
    Jessica A Whiteley; Fiscal Year: 2011
    ..Specifically, we intend to test a 3-month supervised exercise program that also includes comprehensive, theoretically-based, in-person and Internet behavioral coaching to ..
  12. Use of Interactive Gaming for Enhanced Function after Spinal Cord Injury
    BEATRICE JENNY KIRATLI; Fiscal Year: 2011
    ..objective of this project is to implement a program of interactive video gaming as a form of rehabilitation exercise and to evaluate its potential for positive therapeutic outcomes in individuals with spinal cord injury (SCI)...
  13. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..In humans, states of negative energy balance as in anorexia, cachexia, and excessive exercise can all decrease gonadotropins secretion resulting in abnormal cyclicity and infertility...
  14. Effects of Gastric Bypass Surgery on Calcium Metabolism and the Skeleton
    ANNE LOUISE SCHAFER; Fiscal Year: 2013
    ..Obesity is a chronic disease of staggering proportions. Because weight loss through diet and exercise is difficult to attain and maintain, there is escalating interest in surgical weight loss procedures, including ..
  15. A Culturally Tailored LIfestyle Intervention to Prevent Diabetes in South Asians:
    KABAYAM M VENKAT NARAYAN; Fiscal Year: 2010
    ..lifestyle intervention based on the Diabetes Prevention Program (DPP) lifestyle protocol and including: (a) An exercise intervention component, designed to increase program flexibility and acceptability, which includes both in-class ..
  16. Needle-Implantable, Wireless Multi-Sensor for Continuous Glucose Monitoring
    Santhisagar Vaddiraju; Fiscal Year: 2010
    ..e. exercise, irregular homeostatis, anoxia/hypoxia, diet etc.) contribute to interferences that lower sensor accuracy...
  17. Tadalafil for Pulmonary Hypertension Associated with Chronic Lung Disease
    SHARON IRENE SMITH ROUNDS; Fiscal Year: 2013
    ..the effect of phosphodiesterase type-5 (PDE-5) inhibition with tadalafil at 40 mg daily over 12 months on exercise capacity in patients with at least moderate pulmonary hypertension (PH) (mean pulmonary artery pressure [mPAP] &..
  18. Vascular and Skeletal Muscle Function in Gulf War Veterans Illness
    Scott Kinlay; Fiscal Year: 2013
    ..of the proposed three-year pilot study is to determine whether lower extremity (leg) endothelial function, exercise functions, and skeletal muscle mitochondrial gene regulation are different among Veterans with GWVI compared to ..
  19. Secondary Muscle Pathology &Metabolic Dysregulation in Adult with Cerebral Palsy
    Mark Peterson; Fiscal Year: 2013
    ..The candidate has a strong professional background in exercise physiology, and has worked with a variety of populations and spectrum of clinical needs...
  20. Fall risk assessment and prevention in elderly with diabetes using wearable techn
    Bor Rong Chen; Fiscal Year: 2012
    ..improve the perception of lower extremity position during challenging conditions;2) to motivate and guide simple exercise performance in a clinic/home, using an interactive virtual reward-based scheme;and 3) to improve postural control ..
  21. K-Mg-citrate as a BP lowering agent in African Americans; role of natriuresis
    ROBERT FRANKLIN REILLY; Fiscal Year: 2010
    ..Non-pharmacologic approaches, comprised of lifestyle modifications such as exercise, reduction in alcohol consumption, weight loss, and dietary manipulation are accepted as first line management of ..
  22. Improving Hmong Health through Community Based Participatory Research
    DIAN LORENE BAKER; Fiscal Year: 2013
    ..20 percent reported checking their blood glucose at least once a day, and 15 percent reported doing any type of exercise or physical activity...
  23. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
    ..in skeletal muscle and bone mass? Ideally, older adults using a prescribed dietary intervention combined with exercise would be able to preferentially reduce visceral fat mass, while minimizing loss of lean muscle, to obtain maximum ..
  24. Use of Phosphodiesterase Inhibitors to Evaluate the Pathobiology of CF
    JENNIFER L TAYLOR-COUSAR; Fiscal Year: 2013
    ..clinical evidence suggests the potential for improvement in both subjective and objective measurements of exercise tolerance in patients with severe CF lung disease and pulmonary vascular disease who are treated with sildenafil...
  25. Oxidative Stress in Chronic Kidney Disease
    Talat Alp Ikizler; Fiscal Year: 2012
    ..In experimental models and available human studies, healthy lifestyle interventions, such as aerobic exercise and dietary caloric restriction, have demonstrated antioxidant effects mediated via induction of mitochondrial ..
  26. Arm Exercise versus Other Stress Test Modalities for Clinical Outcome Prediction
    WADE HAMPTON MARTIN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Treadmill exercise capacity and hemodynamic, symptomatic, and electrocardiographic (ECG) responses to leg exercise are powerful predictors of all-cause mortality and other important measures of health ..
  27. Research Training in Cardiovascular and Pulmonary Diseases
    S Jamal Mustafa; Fiscal Year: 2012
    ..including: Physiology, Pharmacology, Biochemistry, Cell Biology, Neurobiology, Microbiology, Immunology, Exercise Science, Genetics, Molecular Biology, Internal Medicine, Cardiology and Pulmonology...
  28. Masked Hypertension in Chronic Kidney Disease
    Rajiv Agarwal; Fiscal Year: 2013
    ..4) experience greater sleep disturbances, reduced day-time physical activity, increased body fat, and greater exercise-induced increased BP...
  29. Activity Dependent Signaling in Adult Skeletal Muscle Fiber Plasticity
    Martin F Schneider; Fiscal Year: 2012
    Regular skeletal muscle activity, including endurance exercise, is a key determinant of overall well being, and is crucial for countering the metabolic syndrome of obesity, insulin resistance and hypertension...
  30. Development of Montelukast Delivery System for Childhood Asthma
    Je Phil Ryoo; Fiscal Year: 2013
    ..inhibit bronchoconstriction and prevent many types of asthmatic responses, including allergen-induced, exercise- induced, cold-air-hyperventilation-induced, and aspirin-induced asthma (Wright et al 1998)...
  31. A new ultra-low field in-vivo EPR technology for biomedical applications
    Inseob Hahn; Fiscal Year: 2012
    ..Our aim3B is to perform in vivo human experiments to detect increased free radical concentration during intense exercise. Our ultimate objective is to create a device for human in vivo biomedical EPR that is practical from the ..
  32. A new ultra-low field in-vivo EPR technology for biomedical applications
    Inseob Hahn; Fiscal Year: 2011
    ..Our aim3B is to perform in vivo human experiments to detect increased free radical concentration during intense exercise. Our ultimate objective is to create a device for human in vivo biomedical EPR that is practical from the ..
  33. Respiratory motor control and blood pressure regulation after spinal cord injury
    ..improved by respiratory muscle training (RMT), a rehabilitative technique based on the breathing with resistance exercise. We observed that resting blood pressure and orthostatic tolerance were also improved after RMT in individuals ..
  34. Right Heart-Pulmonary Vascular Interactions in Bronchopulmonary Dysplasia
    Marlowe Eldridge; Fiscal Year: 2013
    ..propose to use a combination of state-of-the-art MR imaging, right heart catheterization, 3D echocardiography and exercise to reveal any abnormalities in the pulmonary vasculature, right heart, and their interactions in our BPD cohort ..
  35. Metabolic Syndrome and Breast Cancer: Effects of a Combined Exercise Intervention
    Christina Dieli-Conwright; Fiscal Year: 2013
    ..Award is intended to assist me in achieving my long-term goal of becoming an independent and productive exercise interventionist for cancer populations, who is able to build and lead transdisciplinary research teams to better ..
  36. AMPK Endothelial Cell Dysfunction and the Metabolic Syndrome (PROGRAM PROJECT)
    Neil B Ruderman; Fiscal Year: 2013
    ..In addition, we will assess the anti-atherogenic and pro-angiogenic effects of exercise in these mice (Projects 1-3)...
  37. RCT of exercise on aromatase inhibitor side effects in breast cancer survivors
    Melinda L Irwin; Fiscal Year: 2012
    ..Nonpharmacologic methods of managing the side effects of the AI's are especially desirable. Exercise has been shown to improve bone metabolism in healthy women, and to be beneficial for people with fibromyalgia, ..
  38. Role of VEGF in Perinatal Hypertension
    STEVEN HERBERT ABMAN; Fiscal Year: 2013
    ..causing prolonged hospitalizations, recurrent respiratory exacerbations, impaired lung function into adulthood, exercise intolerance, and pulmonary hypertension in survivors...
  39. Dysfunctional PGC-1alpha expression in skeletal muscle during diabetes
    S Russ Price; Fiscal Year: 2013
    ..In contrast, exercise can have beneficial effects on muscle in chronic conditions although how its effects are achieved remains unclear...
  40. Microvascular Dysfunction in Hyperhomocysteinemia
    Shawn E Bearden; Fiscal Year: 2012
    ..muscle by reducing cell-cell communication through gap junction and that this impairment can be reversed by exercise training...
  41. Vitamin D Effect on Body Composition During Behavioral Weight Loss in Women
    ANNE M MCTIERNAN; Fiscal Year: 2013
    ..functioning, which could support the adoption of lifestyle behaviors associated with reduced cancer risk, such as exercise. A consistent inverse association is observed between obesity and serum vitamin D level which suggests that some ..
  42. A Pilot Study of Yoga for Breathing and Quality of Life of Lung Cancer Patients
    ..on reported stress, mood, sleep and quality of life of Stage I-IIIa NSCLC patients as compared with a light exercise (LE) group...
  43. Muscle Wasting in Uremia
    Ralph Rabkin; Fiscal Year: 2012
    ..3.) Activation of AMPK with an AMPK agonist (AICAR) to mimic endurance exercise. These studies should provide new insight into the mechanism of muscle wasting in uremia and provide the basis ..
  44. Mechanisms for the Effects of Hypothalamic PTP1B on Energy Balance
    KARYN JOANNE CATALANO; Fiscal Year: 2010
    ..Obesity develops when energy input (e.g. food intake) exceeds energy output (e.g. exercise), and one key regulator of energy balance is the fat-derived hormone leptin, which acts primarily in the brain...
  45. Community Ambulation Following Hip Fracture
    Jay Magaziner; Fiscal Year: 2013
    ..The proposed study will evaluate the ability of a high intensity, 16-week, multi-component exercise program beginning two months post-fracture to improve patients'ability to walk a community ambulation ..
  46. Exercise, Breast Cancer Prevention, and Mechanisms
    Henry J Thompson; Fiscal Year: 2013
    ..who are maintaining body weight in an acceptable range for cancer risk reduction, but who also wish to exercise for further reduction in risk, the relative importance of exercise intensity, duration, and frequency for cancer ..
  47. Development of a Wearable Passive Vibration Therapy System for the Lower Extremit
    JEFFREY MICHAEL LEISMER; Fiscal Year: 2010
    ..b>Exercise is an option that can alleviate many symptoms associated with each condition...
  48. Web-based Patient-Reported Outcomes (PRO) System for Breast Cancer Survivors
    JOHN CHRISTOPHER WEISS; Fiscal Year: 2010
    ..g., dietician, smoking cessation, exercise program, peer support, etc...
  49. Oxygen versus PAP for treatment of sleep apnea in chronic heart failure
    Henry Klar Yaggi; Fiscal Year: 2013
    ..will be change in LVEF as measured by echocardiogram and change in peak VO2 as measured by cardiopulmonary exercise testing...
  50. Oxymax System with Teadmill for Quantifying Exercise in Mice
    Neil B Ruderman; Fiscal Year: 2012
    ..measures, which can be performed concurrently on 8 mice, will allow quantitative assessment and comparison of exercise performance in response to a wide variety of parameters including aging, genetic modifications and drug therapy...
  51. Treatment of Hyperandrogenism vs. Insulin Resistance in Infertile PCOS Women
    Richard S Legro; Fiscal Year: 2012
    ..All treatment arms will follow standardized diet and exercise regimens at this point...
  52. North Lawndale Diabetes Community Action Project
    STEVEN contact WHITMAN; Fiscal Year: 2010
    ..of Diabetes Self-Care Activities measure (SDSCA), a validated instrument assessing general diet, specific diet, exercise, blood-glucose testing, foot care, and smoking behaviors...
  53. Extending Sleep in Obese Adults to Promote Weight Loss
    Ann E Rogers; Fiscal Year: 2010
    ..weight loss programs;2) comparing the efficacy of sleep extension in combination with caloric restriction and exercise to a traditional weight control program consisting of caloric restriction and exercise for facilitating weight ..
  54. Sympathetic Regulation of AMPK in the control of non-shivering thermogenesis
    Jacob D Mulligan; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Efforts to combat the "obesity epidemic" by encouraging exercise and dieting have been largely unsuccessful...
  55. Planning a Multicenter Trial of PDE5A Inhibition for Duchenne Muscular Dystrophy
    Ronald G Victor; Fiscal Year: 2012
    ..which prolong the half-life of cGMP-the downstream target of NO in vascular smooth muscle-rapidly ameliorated exercise-induced muscle ischemia, muscle injury, and fatigue in the mdx mouse model of DMD...
  56. The Effect of Behavioral and Physiological Factors on Obesity Risk in Children
    Karen B Dorsey; Fiscal Year: 2012
    ..The overall goal of the proposed research is to determine the potential utility of exercise testing and physical activity monitoring to support obesity prevention in clinical settings...
  57. Epigenomic regulation of metabolism in muscle by circadian clock and environment
    Zheng Sun; Fiscal Year: 2013
    ..The research that I propose to continue in the independent phase is to study HDAC3 in exercise endurance, fuel selection and efficiency, as well as lipid and amino acid metabolism in skeletal muscle...
  58. Can diet- &exercise-induced weight loss improve asthma control in obese adults?
    Jun Ma; Fiscal Year: 2013
    ..If successful, this project will help advance the current clinical guidelines for treating obese adults with asthma, which, in turn, may lead to reduced morbidity and mortality associated with asthma and obesity. ..
    Kevin L Grove; Fiscal Year: 2013
    ..established that states of energy deficiency, such as fasting, anorexia nervosa, cachexia, bulimia, lactation and exercise-induced amenorrhea, as well as states of energy overabundance, such as obesity, are both associated with ..
  60. Neurotrophic Factors: Genetic Variation and Serum Levels in Brain Aging
    Sudha Seshadri; Fiscal Year: 2010
    ..Experimental and clinical data suggest that circulating NTF levels are increased by a healthy diet and exercise, and decline with age...
  61. Structure and Function of Enzymes in Fatty Acid Oxidation
    JUNG JA P KIM; Fiscal Year: 2013
    ..are the most common of inborn metabolic diseases, resulting in a wide variety of clinical phenotypes ranging from exercise intolerance to failure to thrive...
  62. Exploring the Impact of Negative Energy Balance in Men with Prostate Cancer
    Wendy Demark-Wahnefried; Fiscal Year: 2013
    ..Experiments in humans however have been limited. Our multidisciplinary research team comprised of nutrition, exercise and basic scientists, biostatisticians, and clinicians seeks to conduct a pilot/feasibility study among 40 ..
  63. Randomized Trial of a Postpartum Diabetes Prevention Program for Hispanic Women
    Lisa Chasan-Taber; Fiscal Year: 2013
    ..The intervention will be based on our efficacious exercise and dietary interventions for Hispanics (R01NR011295;WIC Common Pathways). Multimodal contacts (i.e...
  64. Fetal Programming and Human Physical Performance
    Tom Brutsaert; Fiscal Year: 2009
    ..However, notably absent are fetal programming studies that have focused on human physical performance (exercise) outcomes and the response to training...
    Kenneth Beck; Fiscal Year: 2000
    DESCRIPTION (Applicant's abstract): Most studies of exercise induced asthma focus on changes in airway function after exercise...
  66. Exercise-Facilitated NeuroRehabilitation in Diabetic Neuropathy
    EVAN STUBBS; Fiscal Year: 2009
    ..clinical trial is proposed to determine the significance of a combined isokinetic strength and aerobic exercise training program on the rehabilitation of peripheral nerve function in type 2 diabetic veterans with neuropathy...
    Beverly Roberts; Fiscal Year: 2000
    ..Although the positive effects on functional recovery is widely accepted, exercise, as a nursing intervention, has not been empirically tested for its effects on functional recovery after an acute ..
  68. Arterial Baroreflex Function in African Americans at Rest and During Exercise
    David Keller; Fiscal Year: 2009
    ..Moreover, normotensive African Americans exhibit exaggerated blood pressure responses to exercise, as well as to various laboratory pressor stimuli (e.g., cold pressor testing), relative to Caucasian Americans...
  69. Effects of Standardized Aerobic Exercise-Training on Neurocognitive and Neurodege
    Thomas O Obisesan; Fiscal Year: 2010
    ..to determine whether African Americans (AA) with mild AD (AD) can be enrolled and retained in a 6-month aerobic exercise-training study...
  70. Concurrent Upper/Lower Extremity SCI Exercise with Stimulation
    LEE BARNETT; Fiscal Year: 2010
    ..b>Exercise for people with spinal cord injury not only enhances physical fitness but has the potential to slow or reverse ..
  71. Liver Glycogen in Control of Plasma Glucose
    Katarina Borer; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Two spaced bouts of moderate-intensity exercise reduce counterregulatory responses to a next-day hypoglycemic challenge and lead to hypoglycemia, a phenomenon that was characterized as exercise- ..
  72. Adapting Exercise Treatment for Depression to Adolescents: A Pilot Study
    PHILIPPE WEINTRAUB; Fiscal Year: 2010
    ..In adults, exercise has been used as a mono-therapy and as an augmentation therapy with antidepressant medication...
    Michael Lauer; Fiscal Year: 2002
    Although there has been considerable attention paid to the prognostic significance of the heart rate rise during exercise, only recently has it been noted that the heart rate fall after exercise, or "heart-rate recovery," may be an even ..
    Jeffrey Woods; Fiscal Year: 2001
    ..Recent epidemiological evidence suggests that chronic exercise can protect against cancer and infectious disease...
    Harvey Katzeff; Fiscal Year: 1992
    Chronic exercise programs have several advantages when compared to caloric restriction for the treatment of obesity. Chronic exercise produces similar losses of fat mass as underfeeding but lean body mass is maintained...
    SANDRA MOLLENAUER; Fiscal Year: 1993
    The goals of the proposed research are to determine the protective effects of exercise against acute and chronic ethanol (EtOH) intoxication and EtOH withdrawal in C57BL/6J and BALB/cByJ mice, and to provide preliminary information on the ..
    Eric C Hartman; Fiscal Year: 2010
    ..provided by applicant): This Phase II SBIR project proposes to develop an electrical stimulation augmented exercise device for individuals with incomplete spinal cord injury (iSCI)...
    PETER FARRELL; Fiscal Year: 1999
    This project will examine the hypothesis that insulin is critical for exercise-induced increases in rates of protein synthesis and skeletal muscle hypertrophy...
    GERALDINE NEUBERGER; Fiscal Year: 1999
    ..The first aim of this study is to explore the effects of participation in a low-impact aerobic exercise group program versus participation in a home exercise program using a videotape versus a no-treatment control ..
    JAMES JESSUP; Fiscal Year: 2000
    While there is no doubt that exercise promotes health, it also increases the generation of free radicals. Free radicals have been implicated in the number of degenerative diseases associated with aging...
    GEORGE KASPEREK; Fiscal Year: 1993
    Although the major fuels used during exercise are carbohydrates and fats the contribution made by protein is important...
    Timothy Lohman; Fiscal Year: 2000
    ..dietary and hormonal interventions on BMD are being investigated in the Women's Health Initiative, the effects of exercise, a potentially effective stimulus for slowing and possibly reversing bone loss is not assessed...