bullous pemphigoid

Summary

Summary: A chronic and relatively benign subepidermal blistering disease usually of the elderly and without histopathologic acantholysis.

Top Publications

  1. Di Zenzo G, Thoma Uszynski S, Fontao L, Calabresi V, Hofmann S, Hellmark T, et al. Multicenter prospective study of the humoral autoimmune response in bullous pemphigoid. Clin Immunol. 2008;128:415-26 pubmed publisher
    b>Bullous pemphigoid (BP) is an autoimmune bullous disease, associated with autoantibodies directed against the hemidesmosomal components BP180 and BP230...
  2. Shimanovich I, Mihai S, Oostingh G, Ilenchuk T, Brocker E, Opdenakker G, et al. Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoid. J Pathol. 2004;204:519-27 pubmed
    Epidermolysis bullosa acquisita (EBA) and bullous pemphigoid (BP) are two clinically and immunologically distinct autoimmune subepidermal blistering skin diseases associated with IgG autoantibodies against the dermal-epidermal junction...
  3. Olasz E, Roh J, Yee C, Arita K, Akiyama M, Shimizu H, et al. Human bullous pemphigoid antigen 2 transgenic skin elicits specific IgG in wild-type mice. J Invest Dermatol. 2007;127:2807-17 pubmed
    b>Bullous pemphigoid antigen 2 (BPAG2) is targeted by autoantibodies in patients with bullous pemphigoid (BP), and absent in patients with one type of epidermolysis bullosa (OMIM #226650)...
  4. Barnadas M, Gilaberte M, Pujol R, Agustí M, Gelpi C, Alomar A. Bullous pemphigoid in a patient with psoriasis during the course of PUVA therapy: study by ELISA test. Int J Dermatol. 2006;45:1089-92 pubmed
    ..4). Bullous pemphigoid (BP) was diagnosed and therapy with prednisone (60 mg/day) was started...
  5. Joly P, Benichou J, Saiag P, Bernard P, Roujeau J. Response to: mortality rate of bullous pemphigoid in a US medical center. J Invest Dermatol. 2005;124:664-5 pubmed
  6. Powell A, Sakuma Oyama Y, Oyama N, Albert S, Bhogal B, Kaneko F, et al. Usefulness of BP180 NC16a enzyme-linked immunosorbent assay in the serodiagnosis of pemphigoid gestationis and in differentiating between pemphigoid gestationis and pruritic urticarial papules and plaques of pregnancy. Arch Dermatol. 2005;141:705-10 pubmed
    ..The NC16a enzyme-linked immunosorbent assay is highly sensitive and highly specific in differentiating PG from PUPPP, and it is potentially a valuable tool in the serodiagnosis of PG. ..
  7. Barnadas M, Rubiales M, González M, Puig L, Garcia P, Baselga E, et al. Enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence testing in a bullous pemphigoid and pemphigoid gestationis. Int J Dermatol. 2008;47:1245-9 pubmed publisher
    ..BP180-NC16a domain ELISA with that of an indirect immunofluorescence (IIF) testing in the evaluation of bullous pemphigoid (BP) and pemphigoid gestationis (PG), and analyzed the relationship between ELISA results and the presence ..
  8. Marzano A, Tedeschi A, Fanoni D, Bonanni E, Venegoni L, Berti E, et al. Activation of blood coagulation in bullous pemphigoid: role of eosinophils, and local and systemic implications. Br J Dermatol. 2009;160:266-72 pubmed publisher
    b>Bullous pemphigoid (BP) is a blistering skin disease caused by autoantibodies to hemidesmosomal proteins, with eosinophils participating in blister formation...
  9. Waisbourd Zinman O, Ben Amitai D, Cohen A, Feinmesser M, Mimouni D, Adir Shani A, et al. Bullous pemphigoid in infancy: Clinical and epidemiologic characteristics. J Am Acad Dermatol. 2008;58:41-8 pubmed
    Recent cases of infants with bullous pemphigoid (BP) prompted us to explore the clinical and laboratory features of childhood BP. We sought to explore the characteristics of infantile BP and compare them with childhood BP...

More Information

Publications62

  1. Maeda J, Moura A, Maruta C, Santi C, Prisayanh P, Aoki V. Changes in the autoimmune blistering response: a clinical and immunopathological shift from pemphigus foliaceus to bullous pemphigoid. Clin Exp Dermatol. 2006;31:653-5 pubmed
    We describe a 64-year-old Brazilian man who developed bullous pemphigoid (BP) 12 years after pemphigus foliaceus (PF) was diagnosed...
  2. Tsuji Abe Y, Akiyama M, Yamanaka Y, Kikuchi T, Sato Matsumura K, Shimizu H. Correlation of clinical severity and ELISA indices for the NC16A domain of BP180 measured using BP180 ELISA kit in bullous pemphigoid. J Dermatol Sci. 2005;37:145-9 pubmed
    ..by indirect immunofluorescence (IIF) have been used for the diagnosis and evaluation of disease activity in bullous pemphigoid (BP)...
  3. Iranzo P, López I, Robles M, Mascaro J, Campo E, Herrero C. Bullous pemphigoid associated with mantle cell lymphoma. Arch Dermatol. 2004;140:1496-9 pubmed
    b>Bullous pemphigoid has developed in association with different types of malignant diseases, including a few cases of B-cell lymphoproliferative disorders. However, the paraneoplastic significance of this association is still controversial...
  4. Tran J, Mutasim D. Localized bullous pemphigoid: a commonly delayed diagnosis. Int J Dermatol. 2005;44:942-5 pubmed
  5. Fairley J, Fu C, Giudice G. Mapping the binding sites of anti-BP180 immunoglobulin E autoantibodies in bullous pemphigoid. J Invest Dermatol. 2005;125:467-72 pubmed
    b>Bullous pemphigoid (BP) is a subepidermal blistering disease characterized by autoantibodies against the hemidesmosomal protein BP180 (BPAg2, type XVII collagen)...
  6. Joly P, Roujeau J, Benichou J, Delaporte E, D Incan M, Dreno B, et al. A comparison of two regimens of topical corticosteroids in the treatment of patients with bullous pemphigoid: a multicenter randomized study. J Invest Dermatol. 2009;129:1681-7 pubmed publisher
    Superpotent topical corticosteroids (CS) have been demonstrated to improve bullous pemphigoid (BP) patients' survival...
  7. Kiss M, Husz S, Jánossy T, Marczinovits I, Molnar J, Korom I, et al. Experimental bullous pemphigoid generated in mice with an antigenic epitope of the human hemidesmosomal protein BP230. J Autoimmun. 2005;24:1-10 pubmed
    b>Bullous pemphigoid (BP) is an IgG-mediated autoimmune blistering disease that targets the hemidesmosomal proteins BP230 and BP180...
  8. Liu Z, Zhao M, Li N, Diaz L, Mayadas T. Differential roles for beta2 integrins in experimental autoimmune bullous pemphigoid. Blood. 2006;107:1063-9 pubmed
    b>Bullous pemphigoid (BP) is an autoimmune disease associated with autoantibodies directed against the hemidesmosomal antigens anti-BP230 and anti-B180...
  9. Zebrowska A, Waszczykowska E, Wagrowska Danilewicz M, Danilewicz M, Erkiert Polguj A, Pawliczak R, et al. Expression of selected adhesion molecules in dermatitis herpetiformis and bullous pemphigoid. Pol J Pathol. 2009;60:26-34 pubmed
    Dermatitis herpetiformis (DH) and bullous pemphigoid (BP) are autoimmune diseases characterized by destruction of the basement membrane zone (BMZ) and anchoring fibres by autoantibodies and infiltration...
  10. Messingham K, Noe M, Chapman M, Giudice G, Fairley J. A novel ELISA reveals high frequencies of BP180-specific IgE production in bullous pemphigoid. J Immunol Methods. 2009;346:18-25 pubmed publisher
    b>Bullous pemphigoid (BP) is a humoral autoimmune disease directed predominantly against the non-collagenous NC16A domain of the BP180 hemidesmosomal protein...
  11. Di Zenzo G, Grosso F, Terracina M, Mariotti F, De Pita O, Owaribe K, et al. Characterization of the anti-BP180 autoantibody reactivity profile and epitope mapping in bullous pemphigoid patients. J Invest Dermatol. 2004;122:103-10 pubmed
    b>Bullous pemphigoid is a subepidermal bullous disease of skin and mucosae associated with autoantibodies to BP180. To characterize the humoral response to BP180, we generated a random BP180 epitope library displayed on lambda bacteriophage...
  12. Nishie W, Sawamura D, Goto M, Ito K, Shibaki A, McMillan J, et al. Humanization of autoantigen. Nat Med. 2007;13:378-83 pubmed
    ..Here we show that human autoimmune disease can be reproduced using genetically engineered model mice. Bullous pemphigoid (BP) is the most common serious autoimmune blistering skin disease, with a considerable body of indirect ..
  13. Bekou V, Thoma Uszynski S, Wendler O, Uter W, Schwietzke S, Hunziker T, et al. Detection of laminin 5-specific auto-antibodies in mucous membrane and bullous pemphigoid sera by ELISA. J Invest Dermatol. 2005;124:732-40 pubmed
    ..auto-ab) that preferentially recognize two components of the dermoepidermal basement membrane zone (BMZ): bullous pemphigoid (BP)180 and laminin 5 (LN5)...
  14. Nakashima H, Fujimoto M, Asashima N, Watanabe R, Kuwano Y, Yazawa N, et al. Serum chemokine profile in patients with bullous pemphigoid. Br J Dermatol. 2007;156:454-9 pubmed
    b>Bullous pemphigoid (BP) is an autoimmune inflammatory disease causing blister formation at the dermoepidermal junction...
  15. Liu Z, Sui W, Zhao M, Li Z, Li N, Thresher R, et al. Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model. J Autoimmun. 2008;31:331-8 pubmed publisher
    b>Bullous pemphigoid (BP) is a cutaneous autoimmune inflammatory disease associated with subepidermal blistering and autoantibodies against BP180, a transmembrane collagen and major component of the hemidesmosome...
  16. Leuci S, Gürcan H, Ahmed A. Serological studies in bullous pemphigoid: a literature review of antibody titers at presentation and in clinical remission. Acta Derm Venereol. 2010;90:115-21 pubmed publisher
    b>Bullous pemphigoid is associated with antibodies to a 230 kDa and a 180 kDa protein. In a literature review we investigated the role of auto-antibodies as detected by different serological assays...
  17. Garcia Doval I, Mayo E, Nogueira Fariña J, Cruces M. Bullous pemphigoid triggered by influenza vaccination? Ecological study in Galicia, Spain. Br J Dermatol. 2006;155:820-3 pubmed
    Influenza vaccination has been suggested to be a trigger for bullous pemphigoid (BP). In our area most new patients with BP are admitted to hospital...
  18. Colbert R, Allen D, Eastwood D, Fairley J. Mortality rate of bullous pemphigoid in a US medical center. J Invest Dermatol. 2004;122:1091-5 pubmed
    All patients at the Medical College of Wisconsin Affiliated Hospitals with a new diagnosis of bullous pemphigoid (BP) between May 1, 1997 and September 1, 2002 were included in this study...
  19. Olasz E, Yancey K. Bullous pemphigoid and related subepidermal autoimmune blistering diseases. Curr Dir Autoimmun. 2008;10:141-66 pubmed publisher
    The pemphigoid group of autoimmune blistering diseases includes distinct entities (bullous pemphigoid, mucous membrane pemphigoid, pemphigoid gestationis, linear IgA dermatosis and lichen planus pemphigoides) that are characterized by ..
  20. Gudi V, White M, Cruickshank N, Herriot R, Edwards S, Nimmo F, et al. Annual incidence and mortality of bullous pemphigoid in the Grampian Region of North-east Scotland. Br J Dermatol. 2005;153:424-7 pubmed
    Data on the annual incidence of bullous pemphigoid (BP) in the U.K. are scarce. To estimate the annual incidence of BP in Grampian Region (North-east Scotland) and to assess the causes of mortality in this cohort of patients...
  21. Asano Y, Makino T, Norisugi O, Watanabe H, Abe R, Shimizu H, et al. Macrophage migration inhibitory factor (MIF) in bullous pemphigoid. J Dermatol Sci. 2008;49:95-7 pubmed
  22. Feliciani C, Caldarola G, Kneisel A, Podstawa E, Pfütze M, Pfutzner W, et al. IgG autoantibody reactivity against bullous pemphigoid (BP) 180 and BP230 in elderly patients with pruritic dermatoses. Br J Dermatol. 2009;161:306-12 pubmed publisher
    ..Specifically, a prodromal phase of bullous pemphigoid (BP) has to be considered in patients with pruritic lesions of polymorphic appearance...
  23. Marazza G, Pham H, Scharer L, Pedrazzetti P, Hunziker T, Trueb R, et al. Incidence of bullous pemphigoid and pemphigus in Switzerland: a 2-year prospective study. Br J Dermatol. 2009;161:861-8 pubmed publisher
    b>Bullous pemphigoid (BP), pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune bullous diseases characterized by the presence of tissue-bound and circulating autoantibodies directed against disease-specific target antigens ..
  24. Ishiura N, Fujimoto M, Watanabe R, Nakashima H, Kuwano Y, Yazawa N, et al. Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid. J Dermatol Sci. 2008;49:153-61 pubmed
    b>Bullous pemphigoid (BP) is a subepidermal blistering disease characterized by autoantibodies against the hemidesmosomal proteins, BP180 and BP230...
  25. Taghipour K, Chi C, Vincent A, Groves R, Venning V, Wojnarowska F. The association of bullous pemphigoid with cerebrovascular disease and dementia: a case-control study. Arch Dermatol. 2010;146:1251-4 pubmed publisher
    To investigate the relationship between bullous pemphigoid (BP) and neurologic disease. Case-control study. Tertiary care center for immunobullous diseases and skin tumor clinics at a university hospital in Oxford, England...
  26. Zhao M, Trimbeger M, Li N, Diaz L, Shapiro S, Liu Z. Role of FcRs in animal model of autoimmune bullous pemphigoid. J Immunol. 2006;177:3398-405 pubmed
    b>Bullous pemphigoid (BP) is a bullous dermatosis associated with autoantibodies directed against the hemidesmosomal Ags BP180 and BP230...
  27. Iwata H, Kamio N, Aoyama Y, Yamamoto Y, Hirako Y, Owaribe K, et al. IgG from patients with bullous pemphigoid depletes cultured keratinocytes of the 180-kDa bullous pemphigoid antigen (type XVII collagen) and weakens cell attachment. J Invest Dermatol. 2009;129:919-26 pubmed publisher
    We have shown that binding of bullous pemphigoid (BP)-patient IgG (BP-IgG) causes the internalization of BP180 from the cell membrane...
  28. Di Zenzo G, Marazza G, Borradori L. Bullous pemphigoid: physiopathology, clinical features and management. Adv Dermatol. 2007;23:257-88 pubmed
  29. Nelson K, Zhao M, Schroeder P, Li N, Wetsel R, Diaz L, et al. Role of different pathways of the complement cascade in experimental bullous pemphigoid. J Clin Invest. 2006;116:2892-900 pubmed
    b>Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease associated with autoantibodies directed against the hemidesmosomal proteins BP180 and BP230 and inflammation...
  30. Cozzani E, Drosera M, Parodi A, Carrozzo M, Gandolfo S, Rebora A. Frequency of IgA antibodies in pemphigus, bullous pemphigoid and mucous membrane pemphigoid. Acta Derm Venereol. 2004;84:381-4 pubmed
    ..Thirty-two patients with pemphigus, 73 with bullous pemphigoid and 28 with mucous membrane pemphigoid were studied retrospectively...
  31. Ujiie H, Shibaki A, Nishie W, Sawamura D, Wang G, Tateishi Y, et al. A novel active mouse model for bullous pemphigoid targeting humanized pathogenic antigen. J Immunol. 2010;184:2166-74 pubmed publisher
    b>Bullous pemphigoid (BP), the most common autoimmune blistering disease, is caused by autoantibodies against type XVII collagen (COL17)...
  32. Blazsek A, Sillo P, Ishii N, Gergely P, Poor G, Preisz K, et al. Searching for foreign antigens as possible triggering factors of autoimmunity: Torque Teno virus DNA prevalence is elevated in sera of patients with bullous pemphigoid. Exp Dermatol. 2008;17:446-54 pubmed publisher
    ..We performed in silico research to study similarities between known TTV sequences and antigens of bullous pemphigoid (BP), pemphigus vulgaris (PV) and dermatitis herpetiformis (DH)...
  33. Langan S, Smeeth L, Hubbard R, Fleming K, Smith C, West J. Bullous pemphigoid and pemphigus vulgaris--incidence and mortality in the UK: population based cohort study. BMJ. 2008;337:a180 pubmed publisher
    To determine the incidence of and mortality from bullous pemphigoid and pemphigus vulgaris in the United Kingdom. Retrospective historical cohort study...
  34. Umekoji A, Tsuruta D, Inoue T, Nishimori T, Ishii M. Bullous pemphigoid as a dermadrome associated with spindle cell carcinoma of the gallbladder. J Dermatol. 2010;37:251-4 pubmed publisher
    Skin disorders that appear in association with internal malignancies are called dermadromes. Bullous pemphigoid (BP), which is a major autoimmune disease of the skin, is considered to be a dermadrome, although there have been conflicting ..
  35. Zimina E, Hofmann S, Fritsch A, Kern J, Sitaru C, Bruckner Tuderman L. Bullous pemphigoid autoantibodies preferentially recognize phosphoepitopes in collagen XVII. J Invest Dermatol. 2008;128:2736-9 pubmed publisher
  36. Yanagi T, Kato N, Yamane N, Osawa R. Bullous pemphigoid associated with dermatomyositis and colon carcinoma. Clin Exp Dermatol. 2007;32:291-4 pubmed
    It has been suggested that both bullous pemphigoid (BP) and dermatomyositis are associated with internal malignancies. However, there are no reports of the coexistence of these three conditions in one patient...
  37. Zone J, Taylor T, Hull C, Schmidt L, Meyer L. IgE basement membrane zone antibodies induce eosinophil infiltration and histological blisters in engrafted human skin on SCID mice. J Invest Dermatol. 2007;127:1167-74 pubmed
    b>Bullous pemphigoid (BP) is characterized by the deposition of IgG in the basement membrane zone, infiltration of eosinophils, and blister formation...
  38. Kasperkiewicz M, Zillikens D. The pathophysiology of bullous pemphigoid. Clin Rev Allergy Immunol. 2007;33:67-77 pubmed
    b>Bullous pemphigoid (BP) is a blistering skin disease characterized by an autoimmune response to 2 hemidesmosomal proteins within the dermal-epidermal junction, designated BP180 and BP230...
  39. Liu Z, Diaz L, Swartz S, Troy J, Fairley J, Giudice G. Molecular mapping of a pathogenically relevant BP180 epitope associated with experimentally induced murine bullous pemphigoid. J Immunol. 1995;155:5449-54 pubmed
    b>Bullous pemphigoid (BP) and herpes gestationis (HG) are subepidermal blistering diseases associated with an autoimmune response directed against BP180, an epidermal hemidesmosomal glycoprotein...
  40. Lin M, Fu C, Giudice G, Olague Marchan M, Lazaro A, Stastny P, et al. Epitopes targeted by bullous pemphigoid T lymphocytes and autoantibodies map to the same sites on the bullous pemphigoid 180 ectodomain. J Invest Dermatol. 2000;115:955-61 pubmed
    b>Bullous pemphigoid is a blistering skin disease characterized by autoantibodies directed against the NC16A domain of bullous pemphigoid 180 (collagen XVII), a transmembrane protein of epidermal basal cells...
  41. Venning V, Millard P, Wojnarowska F. Dapsone as first line therapy for bullous pemphigoid. Br J Dermatol. 1989;120:83-92 pubmed
    In an open study, a total of 18 patients with proven bullous pemphigoid (16 new patients and two in relapse) were treated with a trial of dapsone (17 patients) or sulphonimide (one patient)...
  42. Joly P, Roujeau J, Benichou J, Picard C, Dreno B, Delaporte E, et al. A comparison of oral and topical corticosteroids in patients with bullous pemphigoid. N Engl J Med. 2002;346:321-7 pubmed
    b>Bullous pemphigoid is the most common autoimmune blistering skin disease of the elderly...
  43. Giudice G, Emery D, Diaz L. Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180. J Invest Dermatol. 1992;99:243-50 pubmed
    b>Bullous pemphigoid (BP) is an autoimmune skin disease that is characterized by the presence of subepidermal blisters resulting from a disruption of the adhesive interactions between basal keratinocytes and the cutaneous basement membrane...
  44. Guo L, Degenstein L, Dowling J, Yu Q, Wollmann R, Perman B, et al. Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration. Cell. 1995;81:233-43 pubmed
    BPAG1 is the major antigenic determinant of autoimmune sera of bullous pemphigoid (BP) patients...
  45. Li K, Tamai K, Tan E, Uitto J. Cloning of type XVII collagen. Complementary and genomic DNA sequences of mouse 180-kilodalton bullous pemphigoid antigen (BPAG2) predict an interrupted collagenous domain, a transmembrane segment, and unusual features in the 5'-end of the gene and t. J Biol Chem. 1993;268:8825-34 pubmed
    ..In this study, we have cloned a mouse collagenous protein, the 180-kDa bullous pemphigoid antigen (BPAG2)...
  46. Kakinuma T, Wakugawa M, Nakamura K, Hino H, Matsushima K, Tamaki K. High level of thymus and activation-regulated chemokine in blister fluid and sera of patients with bullous pemphigoid. Br J Dermatol. 2003;148:203-10 pubmed
    b>Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by eosinophilia and high serum IgE levels. The accumulated evidence suggests that various cytokines are involved in the lesional skin of patients with BP...
  47. Favre B, Fontao L, Koster J, Shafaatian R, Jaunin F, Saurat J, et al. The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression. J Biol Chem. 2001;276:32427-36 pubmed
    The bullous pemphigoid antigen 1 (eBPAG1) is a constituent of hemidesmosomes (HDs), cell-substrate adhesion complexes in stratified epithelia...
  48. Laffitte E, Skaria M, Jaunin F, Tamm K, Saurat J, Favre B, et al. Autoantibodies to the extracellular and intracellular domain of bullous pemphigoid 180, the putative key autoantigen in bullous pemphigoid, belong predominantly to the IgG1 and IgG4 subclasses. Br J Dermatol. 2001;144:760-8 pubmed
    Autoantibodies to the extracellular domain (ECD) of bullous pemphigoid (BP) antigen 180 (BP180) are thought to play a crucial part in the pathophysiology of BP...
  49. Borradori L, Sonnenberg A. Hemidesmosomes: roles in adhesion, signaling and human diseases. Curr Opin Cell Biol. 1996;8:647-56 pubmed
    ..These multiprotein complexes appear not only to mediate cell adhesion, but also to transduce signals from the extracellular matrix to the cell interior that may profoundly modulate cell behavior. ..
  50. Tamai K, Sawamura D, Do H, Tamai Y, Li K, Uitto J. The human 230-kD bullous pemphigoid antigen gene (BPAG1). Exon-intron organization and identification of regulatory tissue specific elements in the promoter region. J Clin Invest. 1993;92:814-22 pubmed
    The 230-kD bullous pemphigoid antigen (BPAG1), a hemidesmosomal protein, is encoded by a gene at the human chromosomal locus 6p11-12...
  51. Liu Z, Roopenian D, Zhou X, Christianson G, Diaz L, Sedmak D, et al. Beta2-microglobulin-deficient mice are resistant to bullous pemphigoid. J Exp Med. 1997;186:777-83 pubmed
    ..Such an hypothesis would predict that beta2m-deficient mice would also be resistant to experimental bullous pemphigoid, a disease with a pathogenesis thought to be much simpler than SLE, being the result of antibody directed ..
  52. Hirako Y, Usukura J, Uematsu J, Hashimoto T, Kitajima Y, Owaribe K. Cleavage of BP180, a 180-kDa bullous pemphigoid antigen, yields a 120-kDa collagenous extracellular polypeptide. J Biol Chem. 1998;273:9711-7 pubmed
    ..One of the putative cell-matrix adhesion molecules present in the HD is the 180-kDa bullous pemphigoid antigen (BP180), also termed type XVII collagen...
  53. Liu Z, Shapiro S, Zhou X, Twining S, Senior R, Giudice G, et al. A critical role for neutrophil elastase in experimental bullous pemphigoid. J Clin Invest. 2000;105:113-23 pubmed
    b>Bullous pemphigoid (BP) is an autoimmune skin disease characterized by subepidermal blisters and autoantibodies against 2 hemidesmosome-associated proteins, BP180 and BP230...