acanthosis nigricans

Summary

Summary: A circumscribed melanosis consisting of a brown-pigmented, velvety verrucosity or fine papillomatosis appearing in the axillae and other body folds. It occurs in association with endocrine disorders, underlying malignancy, administration of certain drugs, or as in inherited disorder.

Top Publications

  1. Mukhtar Q, Cleverley G, Voorhees R, McGrath J. Prevalence of acanthosis nigricans and its association with hyperinsulinemia in New Mexico adolescents. J Adolesc Health. 2001;28:372-6 pubmed
    To determine whether the association between acanthosis nigricans (AN) and hyperinsulinemia is independent of obesity and other variables...
  2. Guran T, Turan S, Akcay T, Bereket A. Significance of acanthosis nigricans in childhood obesity. J Paediatr Child Health. 2008;44:338-41 pubmed publisher
    b>Acanthosis nigricans (AN) is among the most common dermatologic manifestations of obesity and hyperinsulinism. In this study, we aimed to find the clinical and laboratory differences in obese children with AN and without AN (non-AN)...
  3. Nair P, Moorthy P, Suprakasan S, Jayapalan S, Sarin M. Malignant acanthosis nigricans with liver secondaries from an occult primary adenocarcinoma of gastrointestinal tract. Indian J Dermatol Venereol Leprol. 2005;71:197-8 pubmed
    ..on the nape and the sides of the neck with diffuse pigmentation of the face and flexures suggestive of acanthosis nigricans. The dorsa of both the hands showed increased rugosity, hyperpigmentation and hyperkeratosis of the palms, ..
  4. Stuart C, Wen G, Williamson M, Jiang J, Gilkison C, Blackwell S, et al. Altered GLUT1 and GLUT3 gene expression and subcellular redistribution of GLUT4: protein in muscle from patients with acanthosis nigricans and severe insulin resistance. Metabolism. 2001;50:771-7 pubmed
    ..were obtained from 10 normal subjects and 6 obese, nondiabetic subjects with severe insulin resistance and acanthosis nigricans. Both GLUT4 total protein and mRNA were normal in the insulin-resistant subjects...
  5. Castro Feijoo L, Loidi L, Vidal A, Parajes S, Roson E, Alvarez A, et al. Hypochondroplasia and Acanthosis nigricans: a new syndrome due to the p.Lys650Thr mutation in the fibroblast growth factor receptor 3 gene?. Eur J Endocrinol. 2008;159:243-9 pubmed publisher
    ..b>Acanthosis nigricans (AN) is a velvety and papillomatous pigmented hyperkeratosis of the skin, which has been recognized in some ..
  6. Weger W, Ginter Hanselmayer G, Hammer H, Hödl S. Florid cutaneous papillomatosis with acanthosis nigricans in a patient with carcinomas of the lung and prostate. J Am Acad Dermatol. 2007;57:907-8 pubmed
  7. Tavormina P, Bellus G, Webster M, Bamshad M, Fraley A, McIntosh I, et al. A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene. Am J Hum Genet. 1999;64:722-31 pubmed
    ..However, three of the four individuals developed extensive areas of acanthosis nigricans beginning in early childhood, suffer from severe neurological impairments, and have survived past infancy ..
  8. Miquel J, Hadj Rabia S, Boddaert N, Lascelles K, Bahi Buisson N. Atypical presentation of neuropsychiatric lupus with acanthosis nigricans. Pediatr Neurol. 2012;47:291-4 pubmed publisher
    Cutaneous manifestations are commonly observed in pediatric patients with systemic lupus erythematosus. Acanthosis nigricans, however, is rarely reported, and even less often in association with neuropsychiatric manifestations of lupus ..
  9. Akdeniz N, Bilgili S, Aktar S, Yuca S, Calka O, Kilic A, et al. Alström syndrome with acanthosis nigricans: a case report and literature review. Genet Couns. 2011;22:393-400 pubmed
    ..We report a 10 year-old boy presenting with Alström Syndrome and acanthosis nigricans.

More Information

Publications62

  1. Yoshino N, Yamagishi S, Kubokura H, Mikami I, Hirata T, Koizumi K, et al. Mediastinal lymph node metastasis of lung cancer with an unknown primary lesion having concurrent endocrine abnormality and acanthosis nigricans: report of a case. Ann Thorac Cardiovasc Surg. 2009;15:397-400 pubmed
    ..of lung cancer with an unknown primary lesion was complicated by both an endocrine abnormality and acanthosis nigricans. A 66-year-old male visited a local hospital and was diagnosed as having acanthosis nigricans...
  2. Brickman W, Huang J, Silverman B, Metzger B. Acanthosis nigricans identifies youth at high risk for metabolic abnormalities. J Pediatr. 2010;156:87-92 pubmed publisher
    To determine the prevalence of abnormal glucose homeostasis and cardiovascular risk factors in youth with acanthosis nigricans (AN). Youth (8-14 years) were recruited from community pediatric offices...
  3. Stoddart M, Blevins K, Lee E, Wang W, Blackett P. Association of acanthosis nigricans with hyperinsulinemia compared with other selected risk factors for type 2 diabetes in Cherokee Indians: the Cherokee Diabetes Study. Diabetes Care. 2002;25:1009-14 pubmed
    To report prevalence rates of acanthosis nigricans (AN) and hyperinsulinemia and the association of AN with hyperinsulinemia compared with other known or suspected risk factors for type 2 diabetes in young American Indians...
  4. Kebria M, Belinson J, Kim R, Mekhail T. Malignant acanthosis nigricans, tripe palms and the sign of Leser-Tre'lat, a hint to the diagnosis of early stage ovarian cancer: a case report and review of the literature. Gynecol Oncol. 2006;101:353-5 pubmed
    Malignant acanthosis nigricans is a mucocutaneous eruption associated with internal malignancies. Tripe palms refers to a characteristic velvety thickening of the palms, with exaggeration of normal skin markings...
  5. Arnaud Lopez L, Fragoso R, Mantilla Capacho J, Barros Nunez P. Crouzon with acanthosis nigricans. Further delineation of the syndrome. Clin Genet. 2007;72:405-10 pubmed
    Patients with Crouzon and acanthosis nigricans syndrome show craniofacial features similar to those observed in patients with classic Crouzon syndrome, in addition to acanthosis nigricans with peculiar characteristics...
  6. Costa M, Martinez N, Belicha M, Leal F. Acanthosis nigricans and "tripe palm" as paraneoplastic manifestations of metastatic tumor. An Bras Dermatol. 2012;87:498-500 pubmed
    b>Acanthosis nigricans is a common dermatosis and is most often associated with benign conditions, such as insulin resistance. It is rare as a paraneoplastic marker...
  7. Meyers G, Orlow S, Munro I, Przylepa K, Jabs E. Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans. Nat Genet. 1995;11:462-4 pubmed
    ..of a FGFR3 transmembrane domain mutation, Ala391Glu, in three unrelated families with Crouzon syndrome and acanthosis nigricans, a specific skin disorder of hyperkeratosis and hyperpigmentation...
  8. Brickman W, Binns H, Jovanovic B, Kolesky S, Mancini A, Metzger B. Acanthosis nigricans: a common finding in overweight youth. Pediatr Dermatol. 2007;24:601-6 pubmed
    We evaluated the prevalence of acanthosis nigricans among urban youth. Youth (7-17 years) at nine pediatric practices completed surveys on demographics and family history of diabetes and had weight and height measured...
  9. Zankl A, Elakis G, Susman R, Inglis G, Gardener G, Buckley M, et al. Prenatal and postnatal presentation of severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN) due to the FGFR3 Lys650Met mutation. Am J Med Genet A. 2008;146A:212-8 pubmed
    ..prenatal and postnatal features of a patient with severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN). Mutation analysis confirmed the clinical diagnosis by detecting the FGFR3 Lys650Met mutation...
  10. Lopez Alvarenga J, García Hidalgo L, Landa Anell M, Santos Gómez R, González Barranco J, Comuzzie A. Influence of skin color on the diagnostic utility of clinical acanthosis nigricans to predict insulin resistance in obese patients. Arch Med Res. 2006;37:744-8 pubmed
    Skin color may influence the presence of acanthosis nigricans (AN) as predictor of insulin resistance (IR). The objective of this study was to determine how skin color influences the diagnostic utility of AN as a marker of IR...
  11. Leroy J, Nuytinck L, Lambert J, Naeyaert J, Mortier G. Acanthosis nigricans in a child with mild osteochondrodysplasia and K650Q mutation in the FGFR3 gene. Am J Med Genet A. 2007;143A:3144-9 pubmed
    ..5 SDs under the mean for age. By 8 years of age gradually appearing acanthosis nigricans (AN) in the neck and flanks was histopathologically confirmed...
  12. Schnopp C, Baumstark J. Images in clinical medicine. Oral acanthosis nigricans. N Engl J Med. 2007;357:e10 pubmed
  13. Bolding J, Wratchford T, Perkins K, Ogershok P. Prevalence of obesity, acanthosis nigricans and hyperinsulinemia in an adolescent clinic. W V Med J. 2005;101:112-5 pubmed
    ..School of Medicine between April and May 2002 to determine the prevalence of overweight and obesity, acanthosis nigricans and hyperinsulinemia...
  14. Stuart C, Gilkison C, Keenan B, Nagamani M. Hyperinsulinemia and acanthosis nigricans in African Americans. J Natl Med Assoc. 1997;89:523-7 pubmed
    ..Obesity, which usually precedes NIDDM, is associated with the skin lesion acanthosis nigricans in African Americans...
  15. Copeland K, Pankratz K, Cathey V, Immohotichey P, Maddox J, Felton B, et al. Acanthosis Nigricans, insulin resistance (HOMA) and dyslipidemia among Native American children. J Okla State Med Assoc. 2006;99:19-24 pubmed
    It is controversial whether acanthosis nigricans is an independent marker of insulin resistance...
  16. Hirschler V, Aranda C, Calcagno M, Maccalini G, Jadzinsky M. Can waist circumference identify children with the metabolic syndrome?. Arch Pediatr Adolesc Med. 2005;159:740-4 pubmed
    ..004) were significant independent predictors for insulin resistance adjusted for diastolic BP, height, BMI, acanthosis nigricans, and high-density lipoprotein cholesterol level...
  17. Chang Y, Woo H, Sung E, Kim C, Kang H, Ju Y, et al. Prevalence of acanthosis nigricans in relation to anthropometric measures: community-based cross-sectional study in Korean pre-adolescent school children. Pediatr Int. 2008;50:667-73 pubmed publisher
    This cross-sectional study was performed to assess the prevalence of acanthosis nigricans (AN) across various anthropometric measures and to identify the cut-offs for anthropometric indices of adiposity for development of AN in Asian ..
  18. Pinheiro A, Rojas P, Carrasco F, Gomez P, Mayas N, Morales I. Acanthosis nigricans as an indicator of insulin resistance in Chilean adult population. Nutr Hosp. 2011;26:940-4 pubmed publisher
    ..of multiple diseases and its early detection would allow to minimize the associated risk; the presence of acanthosis nigricans (AN) it's associated to the presence of IR...
  19. Magre J, Delepine M, Khallouf E, Gedde Dahl T, Van Maldergem L, Sobel E, et al. Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13. Nat Genet. 2001;28:365-70 pubmed
    ..Other clinical and biological features include acanthosis nigricans, hyperandrogenism, muscular hypertrophy, hepatomegaly, altered glucose tolerance or diabetes mellitus, and ..
  20. Kuroki R, Sadamoto Y, Imamura M, Abe Y, Higuchi K, Kato K, et al. Acanthosis nigricans with severe obesity, insulin resistance and hypothyroidism: improvement by diet control. Dermatology. 1999;198:164-6 pubmed
    We report on a 27-year-old man with acanthosis nigricans (AN) associated with severe obesity, insulin resistance and hypothyroidism. A very low-calorie diet treatment decreased his weight and then ameliorated the insulin-resistant state...
  21. Dash S, Sano H, Rochford J, Semple R, Yeo G, Hyden C, et al. A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia. Proc Natl Acad Sci U S A. 2009;106:9350-5 pubmed publisher
    ..A female presenting at age 11 years with acanthosis nigricans and extreme postprandial hyperinsulinemia was heterozygous for a premature stop mutation (R363X) in TBC1D4...
  22. Kamińska Winciorek G, Brzezińska Wcisło L, Lis Swiety A, Krauze E. Paraneoplastic type of acanthosis nigricans in patient with hepatocellular carcinoma. Adv Med Sci. 2007;52:254-6 pubmed
    Paraneoplastic acanthosis nigricans is connected with malignancies in adults in almost 100% of cases. The typical skin changes include: thickening and hyperpigmentation in typical localization with mucocutaneous involvement...
  23. Rafalson L, Eysaman J, Quattrin T. Screening obese students for acanthosis nigricans and other diabetes risk factors in the urban school-based health center. Clin Pediatr (Phila). 2011;50:747-52 pubmed publisher
    To determine the prevalence of acanthosis nigricans (AN) and other diabetes risk factors in urban school health clinics...
  24. Joshi R, Palwade P. Idiopathic eruptive macular pigmentation or acanthosis nigricans?. Indian J Dermatol Venereol Leprol. 2010;76:591 pubmed publisher
    ..The surface of most lesions had a velvety raised surface similar in appearance to acanthosis nigricans and a biopsy from one of the lesions showed pigmented papillomatosis...
  25. Stulberg D, Clark N, Tovey D. Common hyperpigmentation disorders in adults: Part II. Melanoma, seborrheic keratoses, acanthosis nigricans, melasma, diabetic dermopathy, tinea versicolor, and postinflammatory hyperpigmentation. Am Fam Physician. 2003;68:1963-8 pubmed
    ..While acanthosis nigricans may signal an underlying malignancy (e.g...
  26. Burke J, Hale D, Hazuda H, Stern M. A quantitative scale of acanthosis nigricans. Diabetes Care. 1999;22:1655-9 pubmed
    To develop and validate a scale for acanthosis nigricans (AN). Subjects were participants from the San Antonio Family Diabetes Study and the San Antonio Family Heart Study...
  27. Nagase T, Nagase M, Hirose S, Ohmori K. Crouzon syndrome with acanthosis nigricans: case report and mutational analysis. Cleft Palate Craniofac J. 2000;37:78-82 pubmed
    To describe the 22nd case of Crouzan syndrome with acanthosis nigricans, a hyperkeratotic skin disorder with hyperpigmentation.
  28. Nsiah Kumi P, Beals J, Lasley S, Whiting M, Brushbreaker C, Erickson J, et al. Body mass index percentile more sensitive than acanthosis nigricans for screening Native American children for diabetes risk. J Natl Med Assoc. 2010;102:944-9 pubmed
    Many Native American tribes use acanthosis nigricans to screen for type 2 diabetes risk. We hypothesized that acanthosis nigricans misses many children at risk for type 2 diabetes...
  29. Sinha S, Schwartz R. Juvenile acanthosis nigricans. J Am Acad Dermatol. 2007;57:502-8 pubmed
    b>Acanthosis nigricans is a velvety thickening of the epidermis that primarily affects the axillae, posterior neck fold, flexor skin surfaces, and umbilicus, and infrequently is diffuse with involvement of the mucosal surfaces...
  30. Manco M, Castagneto M, Nanni G, Guidone C, Tondolo V, Greco A, et al. Biliopancreatic diversion as a novel approach to the HAIR-AN syndrome. Obes Surg. 2005;15:286-9 pubmed
    ..a rare multisystem disorder in women, that consists of hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN). The IR is likely due to a primary defect of the insulin receptor...
  31. Berk D, Spector E, Bayliss S. Familial acanthosis nigricans due to K650T FGFR3 mutation. Arch Dermatol. 2007;143:1153-6 pubmed
    b>Acanthosis nigricans is a feature of several syndromes caused by activating mutations of the fibroblast growth factor receptor 3 gene (FGFR3), including Crouzon syndrome with acanthosis nigricans, thanatophoric dysplasia, and severe ..
  32. Kartal Durmazlar S, Eskioglu F, Bodur Z. Hyperkeratosis of the nipple and areola: 2 years of remission with low-dose acitretin and topical calcipotriol therapy. J Dermatolog Treat. 2008;19:337-40 pubmed publisher
    ..Among all reported medical treatments and interventional approaches, including surgery, this is the first patient reported with 2 years of remission. ..
  33. Skiljevic D, Nikolic M, Jakovljevic A, Dobrosavljevic D. Generalized acanthosis nigricans in early childhood. Pediatr Dermatol. 2001;18:213-6 pubmed
    b>Acanthosis nigricans (AN) is a disorder often accompanied by internal malignancy in adult patients, but in children it is usually benign. Generalized forms of AN, especially in childhood, are extremely rare...
  34. Ekpebegh C, Longo Mbenza B. Clinical, immunologic and insulin secretory characteristics of young black South African patients with diabetes: Hospital based single centre study. Diabetes Res Clin Pract. 2013;99:380-4 pubmed publisher
    ..Patients classified as Type 2 had higher waist circumference and higher prevalence of acanthosis nigricans than Types 1A and 1B groups...
  35. Yilmaz E, Kelekci K, Kelekci S. Skin tag and acanthosis nigricans: do they have a predictive value for gestational diabetes mellitus?. Exp Clin Endocrinol Diabetes. 2011;119:419-22 pubmed publisher
    ..and compare the prevalence of gestational diabetes mellitus in pregnant women with skin tag (ST) and/or acanthosis nigricans (AN) and a control group...
  36. Mathur A, Goebel L. Skin findings associated with obesity. Adolesc Med State Art Rev. 2011;22:146-56, ix pubmed
    ..Thus, practitioners will need to become familiar with cutaneous findings associated with obesity in order to diagnose and treat them properly. This article addresses some of the cutaneous findings associated with obesity. ..
  37. Miyashiro D, Sanches J. Paraneoplastic skin disorders: a review. G Ital Dermatol Venereol. 2016;151:55-76 pubmed
    ..The aim of this review was to describe most common paraneoplastic skin diseases. ..
  38. Popa C, Stelea C, Popa R, Popescu E. [Oral and perioral endogenous pigmented lesions]. Rev Med Chir Soc Med Nat Iasi. 2008;112:1054-60 pubmed
    ..In this article, pigmented lesions are described to allow practitioner to elaborate a positive diagnosis of endogenous pigmented lesions and to facilitate an early detection of these lesions particularly the malignant ones...
  39. Hyland V, Robertson S, Flanagan S, Savarirayan R, Roscioli T, Masel J, et al. Somatic and germline mosaicism for a R248C missense mutation in FGFR3, resulting in a skeletal dysplasia distinct from thanatophoric dysplasia. Am J Med Genet A. 2003;120A:157-68 pubmed
    ..of some of the long bones, associated with an S-shaped deformity of the humerus, accompanied by widespread acanthosis nigricans in the integument. These features do not match any previously described skeletal dysplasia...
  40. Dong Z, Huang J, Huang L, Chen X, Yin Q, Yang D. Associations of acanthosis nigricans with metabolic abnormalities in polycystic ovary syndrome women with normal body mass index. J Dermatol. 2013;40:188-92 pubmed publisher
    b>Acanthosis nigricans (AN) usually correlates to insulin resistance (IR) or obesity in obese populations, but adequate studies on the significance of AN in people with normal body mass index (BMI) have not been performed and discussed...
  41. Caceres M, Teran C, Rodriguez S, Medina M. Prevalence of insulin resistance and its association with metabolic syndrome criteria among Bolivian children and adolescents with obesity. BMC Pediatr. 2008;8:31 pubmed publisher
    ..The second objective was determining the relation of acanthosis nigricans and insulin-resistance. We studied 61 obese children and adolescents aged between 5 and 18 years old...
  42. Olson K. Acanthosis nigricans. A guide to assessment and evaluation. Adv Nurse Pract. 2004;12:24-6 pubmed
  43. Kalt A, Wagner A, Zeuzem S, Tilgen W, Reichrath J. [Generalized hyperpigmentation and malignant acanthosis nigricans. A case of a patient with hereditary hemochromatosis and gastric cancer]. Hautarzt. 2005;56:581-5 pubmed
    ..Simultaneous manifestation of hyperpigmentation as a result of hemochromatosis as well as malignant acanthosis nigricans as a paraneoplastic symptom in gastric cancer is very rare.
  44. Levy L, Zeichner J. Dermatologic manifestation of diabetes. J Diabetes. 2012;4:68-76 pubmed publisher
    ..In addition, skin manifestations may precede the diagnosis of diabetes. The present article reviews both the common and less common cutaneous manifestations of DM, including presenting lesions, pathogenesis, and management. ..
  45. Kumandas S, Gumus H, Kurtoglu S, Elmas B, Kontas O. Cohen syndrome with acanthosis nigricans and insulin resistance. J Pediatr Endocrinol Metab. 2001;14:807-10 pubmed
    ..b>Acanthosis nigricans is a cutaneous disorder characterized by hyperpigmentation and papillomatosis...
  46. Gonul M, Cakmak S, Kilic A, Demirel O, Gul U. Acanthosis nigricans with an unusual localization. Australas J Dermatol. 2006;47:212-3 pubmed
  47. Gul U. Acral manifestations of paraneoplastic and collagen vascular diseases. Clin Dermatol. 2017;35:50-54 pubmed publisher
    ..Acral paraneoplastic diseases include acanthosis nigricans maligna, acquired pachydermatoglyphia, acrokeratosis paraneoplastica, palmoplantar keratoderma, and ..
  48. Rodríguez Gutiérrez R, Salcido Montenegro A, González González J. Early Clinical Expressions of Insulin Resistance: The Real Enemy to Look For. Diabetes Ther. 2018;9:435-438 pubmed publisher
    ..Non-alcoholic fatty liver disease, androgenic alopecia, acanthosis nigricans, and polycystic ovarian syndrome are all well-accepted early clinical manifestations of insulin resistance ..
  49. Tan X, Zhang M, Li M, Xiao Y. [Association between acanthosis nigricans and metabolic syndrome in children with obesity]. Zhongguo Dang Dai Er Ke Za Zhi. 2015;17:672-6 pubmed
    To investigate adipokines levels in obese children with acanthosis nigricans (AN) and to explore the relationship between AN and metabolic syndrome (MS)...
  50. Blum A, Rohm S, Grossmann S, Rocken M. [Obligate paraneoplasias of the skin]. Dtsch Med Wochenschr. 2003;128:2195-9 pubmed
  51. Xia Y, Marquart L, Gunning S. What is your diagnosis? Confluent and reticulate papillomatosis (Gougerot-Carteaud syndrome). Cutis. 2007;80:184, 201-2 pubmed
  52. Sepilian V, Crochet J, Nagamani M. Serum soluble leptin receptor levels and free leptin index in women with polycystic ovary syndrome: relationship to insulin resistance and androgens. Fertil Steril. 2006;85:1441-7 pubmed
    ..2] Acute increase in insulin levels during OGTT is associated with an increase in levels of sOB-R. [3] DHEAS may play a role in leptin bioavailability by modulating sOB-R levels. ..
  53. Serin D, Parlak A, Alagoz G, Boran C, Goksugur N. Eyelid involvement in acanthosis nigricans: the importance of systemic screening. Ophthalmic Plast Reconstr Surg. 2005;21:403-4 pubmed
    A 53-year-old man presented with thickening and hyperpigmentation of the eyelids. After the diagnosis of acanthosis nigricans was made, further investigation of a possible underlying disorder, including biochemical and instrumental ..