hydroa vacciniforme

Summary

Summary: A vesicular and bullous eruption having a tendency to recur in summer during childhood and commonly appearing on sun-exposed skin. The lesions are surrounded by an erythematous zone and resemble a vaccination. (From Dorland, 27th ed)

Top Publications

  1. Nishizawa A, Satoh T, Takayama K, Yokozeki H. Hydroa vacciniforme with mucosal involvement and recalcitrant periodontitis and multiple virus re-activators after sun-exposure. Acta Derm Venereol. 2010;90:498-501 pubmed publisher
    An 8-year-old boy presented with hydroa vacciniforme with recurrent oral mucosal ulcers and treatment-resistant gingivitis/periodontitis...
  2. Cho K, Kim C, Heo D, Lee D, Choi W, Rim J, et al. Epstein-Barr virus-associated peripheral T-cell lymphoma in adults with hydroa vacciniforme-like lesions. Clin Exp Dermatol. 2001;26:242-7 pubmed
    ..These patients were diagnosed as having T-cell lymphoma. Interestingly, large granular lymphocytosis was found in the peripheral blood of Case 2...
  3. Gupta G, Man I, Kemmett D. Hydroa vacciniforme: A clinical and follow-up study of 17 cases. J Am Acad Dermatol. 2000;42:208-13 pubmed
    b>Hydroa vacciniforme (HV) is a rare, sporadic, idiopathic photodermatosis characterized by vesicles and crust formation after sunlight exposure. The lesions typically heal with vacciniform scarring...
  4. Xu Z, Lian S. Epstein-Barr virus-associated hydroa vacciniforme-like cutaneous lymphoma in seven Chinese children. Pediatr Dermatol. 2010;27:463-9 pubmed publisher
    b>Hydroa vacciniforme-like cutaneous lymphoma is a rare type of Epstein-Barr virus-associated lymphoma...
  5. Lysell J, Wiegleb Edström D, Linde A, Carlsson G, Malmros Svennilson J, Westermark A, et al. Antiviral therapy in children with hydroa vacciniforme. Acta Derm Venereol. 2009;89:393-7 pubmed publisher
    b>Hydroa vacciniforme is a rare, usually quite severe, photo-dermatosis. Association with Epstein-Barr virus infection and a possibly increased risk of lymphoproliferative malignancy have been demonstrated...
  6. Chen H, Hsiao C, Chiu H. Hydroa vacciniforme-like primary cutaneous CD8-positive T-cell lymphoma. Br J Dermatol. 2002;147:587-91 pubmed
    ..Taiwanese girl had a 6-month history of a relapsing papulovesicular eruption on her face that resembled hydroa vacciniforme (HV). Histologically, there was a dense infiltration of large atypical lymphocytic cells expressing CD8...
  7. Li H, Wang H, Gao T, Zhuo Z, Li D, Li H. [Hydroa vacciniforme-like cutaneous T cell lymphoma: a case report and literature review]. Zhongguo Dang Dai Er Ke Za Zhi. 2009;11:596-8 pubmed
    To study the clinical features, diagnosis and therapy of hydroa vacciniforme-like cutaneous T cell lymphoma...
  8. Takeuchi T, Kamide R. Severe hydroa vacciniforme-like eruptions confined to sun-exposed areas. J Dermatol. 2011;38:386-9 pubmed publisher
    ..Severe hydroa vacciniforme (HV)-like eruptions were diagnosed considering the increased number of the skin lesions with increasing age ..
  9. Li Y, Chen X, Tian X, Li B, Li Z. Primary cutaneous hydroa vacciniforme-like lymphoma with indolent clinical course: report of two cases and review of literature. Int J Surg Pathol. 2013;21:161-8 pubmed publisher
    Primary cutaneous hydroa vacciniforme (HV)-like lymphoma is a rare, Epstein-Barr virus-associated cutaneous neoplasm characterized by photosensitive papulovesicular eruption and usually associated with poor prognosis...

More Information

Publications62

  1. Katagiri Y, Mitsuhashi Y, Kondo S, Kanazawa C, Iwatsuki K, Tsunoda T. Hydroa vacciniforme-like eruptions in a patient with chronic active EB virus infection. J Dermatol. 2003;30:400-4 pubmed
    ..a case of chronic active Epstein-Barr (EB) virus infection (CAEBV) associated with skin eruptions mimicking hydroa vacciniforme (HV) in a 4-year-old boy...
  2. Iwatsuki K, Xu Z, Takata M, Iguchi M, Ohtsuka M, Akiba H, et al. The association of latent Epstein-Barr virus infection with hydroa vacciniforme. Br J Dermatol. 1999;140:715-21 pubmed
    Patients with hydroa vacciniforme (HV)-like eruptions and malignant potential have been reported from Asia and Mexico, and those patients frequently had an associated latent Epstein-Barr virus (EBV) infection...
  3. Zhang Y, Nagata H, Ikeuchi T, Mukai H, Oyoshi M, Demachi A, et al. Common cytological and cytogenetic features of Epstein-Barr virus (EBV)-positive natural killer (NK) cells and cell lines derived from patients with nasal T/NK-cell lymphomas, chronic active EBV infection and hydroa vacciniforme-like eruptions. Br J Haematol. 2003;121:805-14 pubmed
    ..with chronic active EBV infection (CAEBV); and the other cell clone, SNK-11, was from a patient with hydroa vacciniforme (HV)-like eruptions...
  4. Di Lernia V, Mansouri Y. Epstein-Barr virus and skin manifestations in childhood. Int J Dermatol. 2013;52:1177-84 pubmed publisher
    ..Other skin manifestations, not correlated to virus infection, such as hydroa vacciniforme and drug-induced hypersensitivity syndrome have also been linked to EBV...
  5. Kim W, Yeo U, Chun H, Lee E. A case of hydroa vacciniforme with unusual ear mutilation. Clin Exp Dermatol. 1998;23:70-2 pubmed
    ..By the clinical and histologic features of the induced lesions, the case was diagnosed as hydroa vacciniforme (HV). However, no vesicular lesions were found on physical examination...
  6. Kil E, DeLeo V. A survey examination of patients with hydroa vacciniforme. Cutis. 2011;88:245-53 pubmed
    b>Hydroa vacciniforme is a rare acquired photosensitivity disorder that manifests in childhood...
  7. Goodlad J. Epstein-Barr Virus-associated Lymphoproliferative Disorders in the Skin. Surg Pathol Clin. 2017;10:429-453 pubmed publisher
    ..EBV-positive mucocutaneous ulcer, lymphomatoid granulomatosis, EBV-positive diffuse large B-cell lymphoma, hydroa vacciniforme-like lymphoproliferative disorder, and extranodal NK/T-cell lymphoma of nasal type...
  8. Kawamoto K, Miyoshi H, Suzuki T, Kozai Y, Kato K, Miyahara M, et al. A distinct subtype of Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorder: adult patients with chronic active Epstein-Barr virus infection-like features. Haematologica. 2018;103:1018-1028 pubmed publisher
    ..001). Moreover, hypersensitivity to mosquito bites and the occurrence of hydroa vacciniforme were less frequent in patients with adult-onset disease (P<0.001 and P=0...
  9. Cho K, Lee S, Kim C, Jeon Y, Kwon I, Cho Y, et al. Epstein-Barr virus-associated lymphoproliferative lesions presenting as a hydroa vacciniforme-like eruption: an analysis of six cases. Br J Dermatol. 2004;151:372-80 pubmed
    There are many reports of patients with a severe hydroa vacciniforme (HV)-like eruption in which cutaneous lesions occur in both sun-exposed and non-exposed areas, unlike in true HV...
  10. Yamamoto T, Hirai Y, Miyake T, Yamasaki O, Morizane S, Iwatsuki K. Oculomucosal and gastrointestinal involvement in Epstein-Barr virus-associated hydroa vacciniforme. Eur J Dermatol. 2012;22:380-3 pubmed publisher
    In a series of patients with Epstein-Barr virus (EBV)-associated hydroa vacciniforme (HV) and related disorders, we reviewed the incidence of oculomucosal and gastrointestinal involvement...
  11. De Pietro U, Simoni R, Barbieri C, Girolomoni G. Hydroa vacciniforme persistent in a 60-year-old man. Eur J Dermatol. 1999;9:311-2 pubmed
    b>Hydroa vacciniforme (HV) is an idiopathic photodermatosis with onset in childhood, a chronic-recurrent course, and spontaneous resolution in adolescence or early adulthood...
  12. Wierzbicka E, Malthieu F, Villers A, Guillet G. Oral involvement in hydroa vacciniforme. Arch Dermatol. 2006;142:651 pubmed
  13. Lee H, Baek J, Lee J, Park S, Jeon I, Roh J. Atypical hydroa vacciniforme-like epstein-barr virus associated T/NK-cell lymphoproliferative disorder. Am J Dermatopathol. 2012;34:e119-24 pubmed publisher
    ..The CAEBV disease entity encompasses heterogenous disorders, including hydroa vacciniforme (HV), hypersensitivity to mosquito bites, EBV-associated hemophagocytic syndrome, NK/T-cell lymphoma, and ..
  14. Wu Y, Chen H, Hsiao P, Tu M, Lin Y, Wang T. Hydroa vacciniforme-like Epstein-Barr virus-associated monoclonal T-lymphoproliferative disorder in a child. Int J Dermatol. 2007;46:1081-6 pubmed
    b>Hydroa vacciniforme (HV) is a chronic photosensitivity disorder induced by ultraviolet radiation. Hydroa vacciniforme-like lymphoma is a rare cutaneous T-cell lymphoma occurring mainly in childhood...
  15. Suárez Saavedra S, Pérez Guirado A, Santos Juanes J, Concha Torre A, Rodriguez Suarez J. [Facial vesicles]. An Pediatr (Barc). 2007;66:545-6 pubmed
  16. Norris P, Hawk J. The acute idiopathic photodermatoses. Semin Dermatol. 1990;9:32-8 pubmed
    ..photodermatoses are more common in females and comprise polymorphic light eruption, actinic prurigo, hydroa vacciniforme, and solar urticaria...
  17. Almeida H, Kopp J, Jorge V, Sartori D, Velloso C. Extensive hydroa vacciniforme. An Bras Dermatol. 2013;88:620-2 pubmed publisher
    ..Light microscopy showed epidermal necrosis with lymphocytic infiltration . Sunscreens were prescribed with light improvement. ..
  18. Pfau A, Hein R, Karrer S, Landthaler M. [Hydroa vacciniforme]. Dtsch Med Wochenschr. 1996;121:517-20 pubmed
    ..These findings established the diagnosis of hydroa vacciniforme. Prolonged sun exposure was to be avoided and protective ointment was prescribed together with ..
  19. Collins P, Ferguson J. Narrow-band UVB (TL-01) phototherapy: an effective preventative treatment for the photodermatoses. Br J Dermatol. 1995;132:956-63 pubmed
    Twenty patients with photodermatoses [actinic prurigo (n = 6), hydroa vacciniforme (n = 4), idiopathic solar urticaria (n = 1), amiodarone-induced photosensitivity (n = 1) and a range of cutaneous porphyrias (n = 8)] were treated with a '..
  20. Aubin F, Manteaux A, Blanc D, Courtot F, Humbert P, Agache P. [Bazin's hydroa vacciniforme. General review of 2 cases]. Pediatrie. 1990;45:775-80 pubmed
    ..Phototesting may be viewed as an important diagnostic aid, since the induction of lesions, clinically identical to hydroa vacciniform can occur following sequential exposure to UV-A, as was the case in one of our patients. ..
  21. Sangueza M, Plaza J. Hydroa vacciniforme-like cutaneous T-cell lymphoma: clinicopathologic and immunohistochemical study of 12 cases. J Am Acad Dermatol. 2013;69:112-9 pubmed publisher
    b>Hydroa vacciniforme (HV)-like lymphoma (HVL) is a rare and aggressive cutaneous T-cell lymphoma occurring mainly in children in Latin America and Asia. Chronic latent Epstein-Barr virus infection has been associated with both HV and HVL...
  22. Leroy D, Dompmartin A, Michel M, Tack B, Bravard P, Louvet S. Factors influencing the photo-reproduction of hydroa vacciniforme lesions. Photodermatol Photoimmunol Photomed. 1997;13:98-102 pubmed
    b>Hydroa vacciniforme vesicles can be reproduced experimentally with repetitive UVA irradiations, but this photo-reproduction is not constant. The aim of this study was to search for the factors that influence photo-reproduction...
  23. Yesudian P, Sharpe G. Hydroa vacciniforme with oral mucosal involvement. Pediatr Dermatol. 2004;21:555-7 pubmed
    We report the occurrence of oral ulcers in a 6-year-old girl with hydroa vacciniforme. This finding has not hitherto been reported in the literature.
  24. Ketterer R, Morier P, Frenk E. Hydroa vacciniforme. Dermatology. 1994;189:428-9 pubmed
    b>Hydroa vacciniforme is a rare chronic photodermatosis with onset in childhood. It is characterized by recurrent vesicles healing with scars...
  25. Tabata N, Aiba S, Ichinohazama R, Kikuchi K, Aoyama H, Watanabe M, et al. Hydroa vacciniforme-like lymphomatoid papulosis in a Japanese child: a new subset. J Am Acad Dermatol. 1995;32:378-81 pubmed
    ..a 9-month history of a self-healing papulovesicular eruption on her face, scalp, and neck that resembled hydroa vacciniforme (HV)...
  26. Cohen J, Dropulic L, Hsu A, Zerbe C, Krogmann T, Dowdell K, et al. Association of GATA2 Deficiency With Severe Primary Epstein-Barr Virus (EBV) Infection and EBV-associated Cancers. Clin Infect Dis. 2016;63:41-7 pubmed publisher
    ..requiring hospitalization, 1 had chronic active EBV disease (B-cell type), 1 had EBV-associated hydroa vacciniforme-like lymphoma with hemophagocytic lymphohistiocytosis, and 2 had EBV-positive smooth muscle tumors...
  27. Sato K, Taguchi H, Maeda T, Minami H, Asada Y, Watanabe Y, et al. The primary cytotoxicity in ultraviolet-a-irradiated riboflavin solution is derived from hydrogen peroxide. J Invest Dermatol. 1995;105:608-12 pubmed
    ..Under our conditions, two molecules of riboflavin were calculated to produce one molecule of H2O2 after UVA radiation. ..
  28. Heo E, Park S, Kim T. Artificial reproduction of atypical hydRoa vacciniforme caused by latent EpStein-Barr virus infection. Int J Dermatol. 2003;42:476-9 pubmed
    Cases of hydroa vacciniforme-like eruptions caused by latent Epstein-Barr virus (EBV) infection have been reported in Asia and Mexico, some of which progressed to lymphoproliferative disorders...
  29. Sunohara A, Mizuno N, Sakai M, Kawabe Y, Sakakibara S. Action spectrum for UV erythema and reproduction of the skin lesions in hydroa vacciniforme. Photodermatol. 1988;5:139-45 pubmed
    Action spectra for UV erythema and reproduction of the skin lesions in 4 patients with hydroa vacciniforme (HV) were studied...
  30. Sonnex T, Hawk J. Hydroa vacciniforme: a review of ten cases. Br J Dermatol. 1988;118:101-8 pubmed
    Ten patients with hydroa vacciniforme are reported. The condition appears to be a distinct clinical and histological entity. Haematological, biochemical, immunological, bacteriological and viral investigations were negative...
  31. Zeng Y, Fu L, Jin H, Sun Q, Wang B. Hydroa vacciniforme-like Epstein-Barr virus-associated lymphoproliferative disease: a case report. Pediatr Dermatol. 2012;29:96-100 pubmed publisher
    We report a case of hydroa vacciniforme-like skin eruptions with chronic active Epstein-Barr virus infection in a 16-year-old boy...
  32. Lee T, Ko Y. Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea. Bol Med Hosp Infant Mex. 2016;73:10-17 pubmed publisher
    ..and NK-cell LPD with different clinical presentations; one systemic and two cutaneous disorders including hydroa vacciniforme-like T-cell LPD and mosquito bite hypersensitivity...
  33. Rhodes L, White S. Dietary fish oil as a photoprotective agent in hydroa vacciniforme. Br J Dermatol. 1998;138:173-8 pubmed
    b>Hydroa vacciniforme is a troublesome and scarring photosensitivity disorder for which treatment is unsatisfactory...
  34. Blackwell V, McGregor J, Hawk J. Hydroa vacciniforme presenting in an adult successfully treated with cyclosporin A. Clin Exp Dermatol. 1998;23:73-6 pubmed
    b>Hydroa vacciniforme (HV) is a rare photodermatosis first described by Bazin in the mid-nineteenth century. It typically presents in childhood and resolves during adolescence. Rarely, however, symptoms may persist into adult life...
  35. Wong S, Tan S, Khoo S. Late-onset hydroa vacciniforme: two case reports. Br J Dermatol. 2001;144:874-7 pubmed
    b>Hydroa vacciniforme (HV) is a rare blistering photodermatosis that heals with vacciniform scarring, with onset usually in childhood and spontaneous resolution by early adulthood...
  36. Huggins R, Leithauser L, Eide M, Hexsel C, Jacobsen G, Lim H. Quality of life assessment and disease experience of patient members of a web-based hydroa vacciniforme support group. Photodermatol Photoimmunol Photomed. 2009;25:209-15 pubmed publisher
    b>Hydroa vacciniforme (HV) is a rare photodermatosis that primarily affects children. It is characterized by photodistributed vesicles that heal with scarring...
  37. Montalvo N, Redrobán L. Hydroa Vacciniforme-Like EBV-Positive Cutaneous T-Cell Lymphoma, First Report of 2 Cases in Ecuador. Am J Dermatopathol. 2016;38:e57-9 pubmed publisher
    b>Hydroa vacciniforme-like cutaneous lymphoma is a very rare Epstein-Barr virus positive peripheral T-cell lymphoma affecting Asian and Hispanic children and young adults with a defective cytotoxic immune response to EBV predisposing to ..
  38. Mateu A, Rubio M, Diaz F, Ferrando J, Garcia J, Martinez B. [Intermittent vesiculous eruption in a child]. Actas Dermosifiliogr. 2007;98:127-8 pubmed
  39. Morizane S, Suzuki D, Tsuji K, Oono T, Iwatsuki K. The role of CD4 and CD8 cytotoxic T lymphocytes in the formation of viral vesicles. Br J Dermatol. 2005;153:981-6 pubmed
    Herpetic vesicles caused by herpes simplex virus and varicella zoster virus, and hydroa vacciniforme (HV) are characterized by umbilicated vesicule formation.
  40. Jeng B, Margolis T, Chandra N, McCalmont T. Ocular findings as a presenting sign of hydroa vacciniforme. Br J Ophthalmol. 2004;88:1478-9 pubmed
  41. Leroy D, Dompmartin A. [Idiopathic light eruption]. Rev Prat. 1992;42:1354-8 pubmed
    ..Many treatments tested for these PLE seem to be effective, but they have not yet been controlled by double-blind trials. ..
  42. Okumus S, Coskun E, Comez G, Erbagci Z, Comez A, Erbagci I. An unusual case of hydroa vacciniforme with ocular involvement. Med Arch. 2012;66:211-2 pubmed
    b>Hydroa vacciniforme (HV) is a sporadic, rare and idiopathic chronic photodermatosis characterized by recurrent vesicles and crust formation on a sun-exposed skin, typically resulting in vacciniform or varioliform scarring...
  43. Modeste A, Cordel N, Balguerie X, Leroy D, Lauret P, Joly P. [Hydroa vacciniforme: dietary fish oil]. Ann Dermatol Venereol. 2001;128:247-9 pubmed
    ..One recent open study suggested dietary fish oil could be useful. We report a case of hydroa vacciniforme treated successfully with dietary fish oil (Maxepa(R))...
  44. Rodriguez Pinilla S, Barrionuevo C, Garcia J, Martinez M, Pajares R, Montes Moreno S, et al. EBV-associated cutaneous NK/T-cell lymphoma: review of a series of 14 cases from peru in children and young adults. Am J Surg Pathol. 2010;34:1773-82 pubmed publisher
    ..Most (11 out of 14) of these cases fit well into the category of Hydroa vacciniforme-like lymphoma (HVLL), but 3 have a different clinical presentation, without facial involvement...
  45. Wada T, Toga A, Sakakibara Y, Toma T, Hasegawa M, Takehara K, et al. Clonal expansion of Epstein-Barr virus (EBV)-infected ?? T cells in patients with chronic active EBV disease and hydroa vacciniforme-like eruptions. Int J Hematol. 2012;96:443-9 pubmed publisher
    ..Patients with CAEBV may present with cutaneous symptoms, including hypersensitivity to mosquito bites and hydroa vacciniforme (HV)-like eruptions...
  46. Bruderer P, Shahabpour M, Christoffersen S, Andre J, Ledoux M. Hydroa vacciniforme treated by a combination of beta-carotene and canthaxanthin. Dermatology. 1995;190:343-5 pubmed
    b>Hydroa vacciniforme is a very rare photodermatosis, commencing in childhood and belonging to the category of idiopathic burns...
  47. Verneuil L, Gouarin S, Comoz F, Agbalika F, Creveuil C, Varna M, et al. Epstein-Barr virus involvement in the pathogenesis of hydroa vacciniforme: an assessment of seven adult patients with long-term follow-up. Br J Dermatol. 2010;163:174-82 pubmed publisher
    b>Hydroa vacciniforme (HV) is a chronic papulovesicular photodermatosis of childhood, with some cases persisting through adulthood...
  48. Quintanilla Martinez L, Ridaura C, Nagl F, Saez de Ocariz M, Duran McKinster C, Ruiz Maldonado R, et al. Hydroa vacciniforme-like lymphoma: a chronic EBV+ lymphoproliferative disorder with risk to develop a systemic lymphoma. Blood. 2013;122:3101-10 pubmed publisher
    b>Hydroa vacciniforme-like lymphoma (HVLL) is an Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disorder of childhood that occurs mainly in Central and South America and Asia...
  49. Durbec F, Reguiai Z, Léonard F, Pluot M, Bernard P. Efficacy of ?-3 polyunsaturated fatty acids for the treatment of refractory hydroa vacciniforme. Pediatr Dermatol. 2012;29:118-9 pubmed publisher
    b>Hydroa vacciniforme (HV) is a rare photodermatosis. Several therapies, with sometimes severe side effects, have been used in isolated cases...
  50. Ruiz Maldonado R, Parrilla F, Orozco Covarrubias M, Ridaura C, Tamayo Sanchez L, Duran McKinster C. Edematous, scarring vasculitic panniculitis: a new multisystemic disease with malignant potential. J Am Acad Dermatol. 1995;32:37-44 pubmed
    b>Hydroa vacciniforme (HV) is a disease of unknown origin characterized by erythema, vesicles, necrosis, and varicelliform scars in light-exposed skin. Systemic involvement is absent...
  51. Bennion S, Johnson C, Weston W. Hydroa vacciniforme with inflammatory keratitis and secondary anterior uveitis. Pediatr Dermatol. 1987;4:320-4 pubmed
    A 6-year-old boy had numerous episodes of hydroa vacciniforme. Several of these episodes were accompanied by an anterior uveitis with corneal clouding and stellate keratic precipitates...
  52. Wisuthsarewong W, Leenutaphong V, Viravan S. Hydroa vacciniforme with ocular involvement. J Med Assoc Thai. 1998;81:807-11 pubmed
    A 7-year-old Thai boy had several episodes of hydroa vacciniforme which were accompanied by an anterior uveitis with corneal clouding and stellate keratic precipitates...
  53. Yamamoto T, Tsuji K, Suzuki D, Morizane S, Iwatsuki K. A novel, noninvasive diagnostic probe for hydroa vacciniforme and related disorders: detection of latency-associated Epstein-Barr virus transcripts in the crusts. J Microbiol Methods. 2007;68:403-7 pubmed
    ..EBV infections in cutaneous lesions of EBV-associated NK/T-cell lymphoproliferative disorders, including hydroa vacciniforme (HV) and hypersensitivity to mosquito bites (HMB)...