pityriasis rosea


Summary: A mild exanthematous inflammation of unknown etiology. It is characterized by the presence of salmon-colored maculopapular lesions. The most striking feature is the arrangement of the lesions such that the long axis is parallel to the lines of cleavage. The eruptions are usually generalized, affecting chiefly the trunk, and the course is often self-limiting.

Top Publications

  1. Watanabe T, Kawamura T, Jacob S, Aquilino E, Orenstein J, Black J, et al. Pityriasis rosea is associated with systemic active infection with both human herpesvirus-7 and human herpesvirus-6. J Invest Dermatol. 2002;119:793-7 pubmed
    b>Pityriasis rosea is a common skin disease that has been suspected to have a viral etiology...
  2. Chuh A. A prospective case control study of autoimmune markers in patients with pityriasis rosea. Clin Exp Dermatol. 2003;28:449-50 pubmed
  3. Lallas A, Kyrgidis A, Tzellos T, Apalla Z, Karakyriou E, Karatolias A, et al. Accuracy of dermoscopic criteria for the diagnosis of psoriasis, dermatitis, lichen planus and pityriasis rosea. Br J Dermatol. 2012;166:1198-205 pubmed publisher
    ..Plaque psoriasis (PP), dermatitis, lichen planus (LP) and pityriasis rosea (PR) are common inflammatory skin diseases, but little is currently known about their dermoscopic features...
  4. Deng Y, Li H, Chen X. Palmoplantar pityriasis rosea: two case reports. J Eur Acad Dermatol Venereol. 2007;21:406-7 pubmed
  5. Bernardin R, Ritter S, Murchland M. Papular pityriasis rosea. Cutis. 2002;70:51-5; quiz 48 pubmed
    b>Pityriasis rosea (PR) is a seasonal papulosquamous disorder that can be easily confused with a wide variety of similar appearing cutaneous disorders. This is particularly evident in its atypical papular form...
  6. Vag T, Sonkoly E, Karpati S, Kemeny B, Ongradi J. Avidity of antibodies to human herpesvirus 7 suggests primary infection in young adults with pityriasis rosea. J Eur Acad Dermatol Venereol. 2004;18:738-40 pubmed
  7. Sezer E, Saracoglu Z, Urer S, Bildirici K, Sabuncu I. Purpuric pityriasis rosea. Int J Dermatol. 2003;42:138-40 pubmed
  8. Drago F, Vecchio F, Rebora A. Use of high-dose acyclovir in pityriasis rosea. J Am Acad Dermatol. 2006;54:82-5 pubmed
    The association of human herpesvirus 6 (HHV-6) and HHV-7 with pityriasis rosea suggests that systemic drugs directed against HHV may hasten recovery of patients with pityriasis rosea.
  9. Chuh A, Kempf W. The identification of primary human herpesvirus 7 infection in young adults with pityriasis rosea by investigating avidity of antibodies. J Eur Acad Dermatol Venereol. 2006;20:629-30 pubmed

More Information


  1. Drago F, Malaguti F, Ranieri E, Losi E, Rebora A. Human herpes virus-like particles in pityriasis rosea lesions: an electron microscopy study. J Cutan Pathol. 2002;29:359-61 pubmed
    ..features of human herpes viruses in the supernatant of cocultured mononuclear cells from patients with acute pityriasis rosea. Because of their morphology and of polymerase chain reaction studies, we ascribed them to human herpes virus ..
  2. Canpolat Kirac B, Adisen E, Bozdayi G, Yucel A, Fidan I, Aksakal N, et al. The role of human herpesvirus 6, human herpesvirus 7, Epstein-Barr virus and cytomegalovirus in the aetiology of pityriasis rosea. J Eur Acad Dermatol Venereol. 2009;23:16-21 pubmed publisher
    To identify the role of human herpesvirus 6 (HHV-6), HHV-7, Epstein-Barr virus (EBV) and cytomegalovirus (CMV) in the pathogenesis of pityriasis rosea (PR).
  3. Drago F, Broccolo F, Rebora A. Pityriasis rosea: an update with a critical appraisal of its possible herpesviral etiology. J Am Acad Dermatol. 2009;61:303-18 pubmed publisher
    b>Pityriasis rosea is an acute, self-healing exanthem characterized by oval erythematous-squamous lesions of the trunk and limbs, that usually spares face, scalp, palms, and soles...
  4. Aydogan K, Karadogan S, Adim S, Tunali S. Pityriasis rosea-like eruption due to ergotamine: a case report. J Dermatol. 2005;32:407-9 pubmed
  5. Gangemi S, Cannavo S, Guarneri F, Merendino R, Sturniolo G, Minciullo P, et al. The CX3C-chemokine fractalkine (CX3CL1) is detectable in serum of patients affected by active pityriasis rosea. J Eur Acad Dermatol Venereol. 2006;20:1366-7 pubmed
  6. Guarneri C, Polimeni G, Nunnari G. Pityriasis rosea during etanercept therapy. Eur Rev Med Pharmacol Sci. 2009;13:383-7 pubmed
    ..We present herein the first two cases of Gibert's pityriasis rosea occurring during etanercept therapy and discuss possible links between this common, etiologically still ..
  7. Prantsidis A, Rigopoulos D, Papatheodorou G, Menounos P, Gregoriou S, Alexiou Mousatou I, et al. Detection of human herpesvirus 8 in the skin of patients with pityriasis rosea. Acta Derm Venereol. 2009;89:604-6 pubmed publisher
    b>Pityriasis rosea is an acute self-limiting dermatosis with clinical and epidemiological features that suggest viral involvement...
  8. Atzori L, Pinna A, Ferreli C, Aste N. Pityriasis rosea-like adverse reaction: review of the literature and experience of an Italian drug-surveillance center. Dermatol Online J. 2006;12:1 pubmed
    b>Pityriasis rosea is a common, acute eruption of uncertain etiology...
  9. Güleç A, Albayrak H, Kayapinar O, Albayrak S. Pityriasis rosea-like adverse reaction to atenolol. Hum Exp Toxicol. 2016;35:229-31 pubmed publisher
    ..The patient was diagnosed as pityriasis rosea-like adverse reaction to atenolol based on her history, dermatological examination and histopathological ..
  10. Sinha S, Sardana K, Garg V. Coexistence of two atypical variants of pityriasis rosea: a case report and review of literature. Pediatr Dermatol. 2012;29:538-40 pubmed publisher
    ..Histopathologic examination was performed, and she was diagnosed with pityriasis rosea presenting with two atypical morphological variants-generalized papular and erythema multiforme-like...
  11. González L, Allen R, Janniger C, Schwartz R. Pityriasis rosea: an important papulosquamous disorder. Int J Dermatol. 2005;44:757-64 pubmed
  12. Rasi A, Tajziehchi L, Savabi Nasab S. Oral erythromycin is ineffective in the treatment of pityriasis rosea. J Drugs Dermatol. 2008;7:35-8 pubmed
    Despite the availability of various medical treatments for pityriasis rosea, a large percentage of patients fail to achieve satisfactory results. Erythromycin is reported to be effective in the treatment of pityriasis rosea...
  13. Miranda S, Lupi O, Lucas E. Vesicular pityriasis rosea: response to erythromycin treatment. J Eur Acad Dermatol Venereol. 2004;18:622-5 pubmed
    b>Pityriasis rosea (PR) is a relatively common disease although its aetiology has not yet been identified. It occurs worldwide and there is no racial susceptibility factor...
  14. Chuh A. The association of pityriasis rosea with cytomegalovirus, Epstein-Barr virus and parvovirus B19 infections - a prospective case control study by polymerase chain reaction and serology. Eur J Dermatol. 2003;13:25-8 pubmed
    A viral aetiology is suspected for pityriasis rosea (PR). The objective was to investigate the association of PR with cytomegalovirus (CMV), Epstein Barr virus (EBV) and parvovirus B19 infections...
  15. Chuh A. Diagnostic criteria for pityriasis rosea: a prospective case control study for assessment of validity. J Eur Acad Dermatol Venereol. 2003;17:101-3 pubmed
  16. Kim D, Je J, Kim S, Shin D, Kim T, Kim D, et al. Programmed death-ligand 1, 2 expressions are decreased in the psoriatic epidermis. Arch Dermatol Res. 2015;307:531-8 pubmed publisher
    ..stainings were done in skin biopsy samples from psoriasis, normal skin, allergic contact dermatitis (ACD), pityriasis rosea (PR) and lichen planus (LP)...
  17. Wong W, Tsai C, Shih S, Chan H. Association of pityriasis rosea with human herpesvirus-6 and human herpesvirus-7 in Taipei. J Formos Med Assoc. 2001;100:478-83 pubmed
    b>Pityriasis rosea (PR) is a common papulosquamous skin disease with unknown etiology. The possible relationship of PR with human herpesvirus infection (HHV) has been extensively studied...
  18. Cook B, Crutchfield C. Pityriasis rosea. Dermatol Nurs. 2006;18:370 pubmed
  19. Zawar V. Bilateral scaly plaques in axillae: pityriasis rosea of Vidal. Skinmed. 2012;10:257-8 pubmed
    ..He remained asymptomatic until axillary lesions appeared. We made a provisional diagnosis of pityriasis rosea (PR)...
  20. Kosuge H, Tanaka Taya K, Miyoshi H, Amo K, Harada R, Ebihara T, et al. Epidemiological study of human herpesvirus-6 and human herpesvirus-7 in pityriasis rosea. Br J Dermatol. 2000;143:795-8 pubmed
    b>Pityriasis rosea (PR) is a common papulosquamous skin disorder that is suspected to have an infectious aetiology. We aimed to study the role of human herpesvirus (HHV)-7 and HHV-6 in the pathogenesis of PR...
  21. De Keyser F, Naeyaert J, Hindryckx P, Elewaut D, Verplancke P, Peene I, et al. Immune-mediated pathology following hepatitis B vaccination. Two cases of polyarteritis nodosa and one case of pityriasis rosea-like drug eruption. Clin Exp Rheumatol. 2000;18:81-5 pubmed
    ..A third patient developed a severe pityrias rosea-like eruption. He was treated with topical steroids with healing of the lesions, leaving only post-inflammatory hyperpigmentation. The literature on these associations is reviewed. ..
  22. Chuh A, Lee A, Molinari N. Case clustering in pityriasis rosea: a multicenter epidemiologic study in primary care settings in Hong Kong. Arch Dermatol. 2003;139:489-93 pubmed
    To investigate the epidemiology of pityriasis rosea in primary care settings in Hong Kong and to analyze for temporal clustering. Retrospective epidemiologic study. Six primary care teaching practices affiliated with a university...
  23. Andersen L, Davis M. Sex differences in the incidence of skin and skin-related diseases in Olmsted County, Minnesota, United States, and a comparison with other rates published worldwide. Int J Dermatol. 2016;55:939-55 pubmed publisher
    ..morphea, dermatomyositis, primary Sjögren syndrome, systemic lupus erythematosus [not in all studies]), pityriasis rosea, herpes progenitalis, condyloma acuminatum, hidradenitis suppurativa, herpes zoster (except in children), ..
  24. Fölster Holst R, Zawar V, Chuh A. [Paraviral exanthems]. Hautarzt. 2017;68:211-216 pubmed publisher
    ..Viruses cannot be identified in the skin. Typical paraviral exanthems include Gianotti-Crosti syndrome, pityriasis rosea, pityriasis lichenoides, papular-purpuric gloves and sock syndrome, and asymmetrical periflexural exanthema...
  25. Amatya A, Rajouria E, Karn D. Comparative study of effectiveness of oral acyclovir with oral erythromycin in the treatment of Pityriasis rosea. Kathmandu Univ Med J (KUMJ). 2012;10:57-61 pubmed
    b>Pityriasis rosea is an acute, self-limiting disease, probably infective in origin, affecting mainly children and young adults, characterized by distinctive skin eruptions and minimal constitutional symptoms...
  26. Fu L, Xu C, Zheng X, Chen G, Zhu J, Wang P. Association of HLA-DQB1*03:03 with pityriasis rosea in Chinese patients. Clin Exp Dermatol. 2017;: pubmed publisher
    The association of human leucocyte antigen (HLA) with a variety of diseases has been described, especially with various autoimmune diseases. However, there are few studies on the association between HLA and pityriasis rosea (PR).
  27. Hanjani N, Rencic A, Whitmore S. Pityriasis rosea-like eruption due to bismuth. Cutis. 2006;77:166-8 pubmed
    We report a case of bismuth-induced pityriasis rosea-like drug eruption. Although historical accounts of bismuth hypersensitivity exist, contemporary reports are lacking...
  28. Balci D, Hakverdi S. Vesicular pityriasis rosea: an atypical presentation. Dermatol Online J. 2008;14:6 pubmed
    b>Pityriasis rosea (PR) is an acute, self-limited papulosquamous dermatosis localized on the trunk and extremities. PR is seen most frequently in adolescents and young adults...
  29. Yang C, Teeple M, Muglia J, Robinson Bostom L. Inflammatory and glandular skin disease in pregnancy. Clin Dermatol. 2016;34:335-43 pubmed publisher
    ..atopic eruption of pregnancy), psoriasis, impetigo herpetiformis, urticaria, erythema annulare centrifugum, pityriasis rosea, sarcoidosis, Sweet syndrome, and erythema nodosum, as well as glandular skin diseases, including acne ..
  30. Grzybowski A, Nita M. Leprosy in the Bible. Clin Dermatol. 2016;34:3-7 pubmed publisher
    ..Psoriasis, seborrheic dermatitis, favus, dermatophyte infections, nummular dermatitis, atopic dermatitis, pityriasis rosea, crusted scabies, syphilis, impetigo, sycosis barbae, alopecia areata, furuncles, scabies, neurodermatitis, ..
  31. Bianca S, Ingegnosi C, Ciancio B, Gullotta G, Randazzo L, Ettore G. Pityriasis rosea in pregnancy. Reprod Toxicol. 2007;24:277-8 pubmed
  32. Browning J. An update on pityriasis rosea and other similar childhood exanthems. Curr Opin Pediatr. 2009;21:481-5 pubmed publisher
    b>Pityriasis rosea is a common skin condition seen in children and adults. Whereas pityriasis rosea is a benign condition, it is important to distinguish it from other childhood exanthems...
  33. El Ela M, Shaarawy E, El Komy M, Fawzy M, Hay R, Hegazy R, et al. Is There a Link between Human Herpesvirus Infection and Toll-like Receptors in the Pathogenesis of Pityriasis Rosea? A Case-control Study. Acta Dermatovenerol Croat. 2016;24:282-287 pubmed
    Human herpesvirus (HHV) 6 and 7 are involved in the pathogenesis of pityriasis rosea (PR)...
  34. Rassai S, Feily A, Sina N, Abtahian S. Low dose of acyclovir may be an effective treatment against pityriasis rosea: a random investigator-blind clinical trial on 64 patients. J Eur Acad Dermatol Venereol. 2011;25:24-6 pubmed publisher
    b>Pityriasis rosea (PR) is a papulosquamous disease with an unknown aetiology, but recently the role of two herpes viruses human herpes virus 6 and human herpes virus 7 was defined as being the aetiology of PR...
  35. Gru A, Salavaggione A. Common spongiotic dermatoses. Semin Diagn Pathol. 2017;34:226-236 pubmed publisher
    ..The dermatoses that will be discussed under this category include contact dermatitis, eczema, pityriasis rosea, stasis dermatitis, seborrheic dermatitis and others.
  36. Traore A, Korsaga Some N, Niamba P, Barro F, Sanou I, Drabo Y. [Pityriasis rosea in secondary schools in Ouagadougou, Burkina Faso]. Ann Dermatol Venereol. 2001;128:605-9 pubmed
    b>Pityriasis rosea is a spontaneously regressive benign erythematous squamous dermatosis. A better understanding of this condition in developing countries would be useful...
  37. Clavier A, Hupert J. Azithromycin for pityriasis. Pediatrics. 2006;118:2257; author reply 2257-8 pubmed
  38. Adamic M, Pavlovic M. What is the news? A difference between men and women. Dermatol Online J. 2008;14:23 pubmed
    ..We questioned 63 consecutive patients with pityriasis rosea and found that the women were overwhelmingly more likely than men to ask to hear unpleasant information ..
  39. Lafuente C. Is it scabies? How to tell. Nurse Pract. 2003;28:57-9 pubmed
  40. García F Villalta M, Hernández Núñez A, Cordoba S, Fernandez Herrera J, Garcia Diez A. Atypical pityriasis rosea and Hodgkin's disease. J Eur Acad Dermatol Venereol. 2004;18:81-2 pubmed
    b>Pityriasis rosea (PR)-like eruptions have been associated with several neoplasms and drugs. These eruptions may be atypical. To date, the association of Hodgkin's disease with PR-like eruptions has rarely been reported...
  41. Chuh A. Rash orientation in pityriasis rosea: a qualitative study. Eur J Dermatol. 2002;12:253-6 pubmed
    Rash orientation in pityriasis rosea (PR) has been described as Christmas-tree pattern, inverted Christmas-tree pattern, fir tree pattern, parallel to the ribs or along skin cleavage lines...
  42. Turchin I, Adams S, Enta T. Dermacase. Pityriasis rosea. Can Fam Physician. 2004;50:41, 49-50 pubmed
  43. Flamm A, Parikh K, Xie Q, Kwon E, Elston D. Histologic features of secondary syphilis: A multicenter retrospective review. J Am Acad Dermatol. 2015;73:1025-30 pubmed publisher
    ..1% vs 34.4% overall), demonstrate rete ridge effacement (44.8% vs 19.8%), and have pityriasis rosea (33.3% vs 17.2%) or drug eruption (33.3% vs 10.9%) in the clinical differential...
  44. Nelson J, Stone M. Update on selected viral exanthems. Curr Opin Pediatr. 2000;12:359-64 pubmed
    ..the recent literature pertaining to four characteristic exanthems that are thought to be viral in nature: papular purpuric gloves and socks syndrome; pityriasis rosea; unilateral lateral thoracic exanthem; and Gianotti-Crosti syndrome.
  45. Stulberg D, Wolfrey J. Pityriasis rosea. Am Fam Physician. 2004;69:87-91 pubmed
    b>Pityriasis rosea is a common, acute exanthem of uncertain etiology. Viral and bacterial causes have been sought, but convincing answers have not yet been found. Pityriasis rosea typically affects children and young adults...
  46. Korge B. [Pityriasis rosea. Reactivation of human Herpesvirus 6 and 7 infection?]. Hautarzt. 2003;54:78-9 pubmed
  47. Krishnamurthy K, Walker A, Gropper C, Hoffman C. To treat or not to treat? Management of guttate psoriasis and pityriasis rosea in patients with evidence of group A Streptococcal infection. J Drugs Dermatol. 2010;9:241-50 pubmed
    The association between guttate psoriasis and pityriasis rosea with Streptococcus pyogenes (S...
  48. Chuh A. The use of digital epiluminescence dermatoscopy to identify peripheral scaling in pityriasis rosea. Comput Med Imaging Graph. 2002;26:129-34 pubmed
    ..Non-digital and digital ED can assist to identify peripheral scaling in pityriasis rosea (PR)...
  49. Chuh A, Zawar V, Lee A. Atypical presentations of pityriasis rosea: case presentations. J Eur Acad Dermatol Venereol. 2005;19:120-6 pubmed
    Atypical cases of pityriasis rosea (PR) are fairly common and less readily recognized than typical eruptions. We present four patients for whom we believe atypical PR is the most likely diagnosis...
  50. Chuh A, Lee A, Chan P. Pityriasis rosea in pregnancy--specific diagnostic implications and management considerations. Aust N Z J Obstet Gynaecol. 2005;45:252-3 pubmed
  51. Schepis C, Siragusa M. The Meyerson phenomenon in a teenager. Dermatol Online J. 2008;14:28 pubmed
  52. Amer A, Fischer H, Li X. The natural history of pityriasis rosea in black American children: how correct is the "classic" description?. Arch Pediatr Adolesc Med. 2007;161:503-6 pubmed
    To delineate the natural history of pityriasis rosea in black children and to compare our findings with those of the American, European, and African literature on pityriasis rosea...
  53. Rajpara S, Ormerod A, Gallaway L. Adalimumab-induced pityriasis rosea. J Eur Acad Dermatol Venereol. 2007;21:1294-6 pubmed