pityriasis lichenoides

Summary

Summary: A subgroup of PARAPSORIASIS itself divided into acute and chronic forms. The acute form is characterized by the abrupt onset of a generalized, reddish-brown, maculopapular eruption. Lesions may be vesicular, hemorrhagic, crusted, or necrotic. Histologically the disease is characterized by epidermal necrolysis. The chronic form shows milder skin changes with necrosis.

Top Publications

  1. Aydogan K, Saricaoglu H, Turan H. Narrowband UVB (311 nm, TL01) phototherapy for pityriasis lichenoides. Photodermatol Photoimmunol Photomed. 2008;24:128-33 pubmed publisher
    ..The purpose of the present study was to assess the efficacy of NB-UVB phototherapy in the management of pityriasis lichenoides (PL)...
  2. Shieh S, Mikkola D, Wood G. Differentiation and clonality of lesional lymphocytes in pityriasis lichenoides chronica. Arch Dermatol. 2001;137:305-8 pubmed
    b>Pityriasis lichenoides chronica (PLC) and pityriasis lichenoides et varioliformis acuta (PLEVA) are benign T-cell diseases that share several overlapping clinicopathologic features, leading many to believe that they exist as a spectrum ..
  3. Tsianakas A, Hoeger P. Transition of pityriasis lichenoides et varioliformis acuta to febrile ulceronecrotic Mucha-Habermann disease is associated with elevated serum tumour necrosis factor-alpha. Br J Dermatol. 2005;152:794-9 pubmed
    ..ulceronecrotic Mucha-Habermann disease (FUMHD) represents a fulminant and potentially lethal variant of pityriasis lichenoides. Only 24 cases have been described so far...
  4. Khachemoune A, Blyumin M. Pityriasis lichenoides: pathophysiology, classification, and treatment. Am J Clin Dermatol. 2007;8:29-36 pubmed
    b>Pityriasis lichenoides (PL) is an uncommon, acquired spectrum of skin conditions that poses various challenges to patients as well as clinicians. It is a difficult and debatable disorder to diagnose, categorize, and treat...
  5. Weinberg J, Kristal L, Chooback L, Honig P, Kramer E, Lessin S. The clonal nature of pityriasis lichenoides. Arch Dermatol. 2002;138:1063-7 pubmed
    b>Pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC) are benign lymphocytic infiltrates of the skin that classically present as either a recurrent papulonecrotic eruption (PLEVA) or a persistent, ..
  6. Jang K, Choi J, Choi J. Expression of cutaneous lymphocyte-associated antigen and TIA-1 by lymphocytes in pityriasis lichenoides et varioliformis acuta and lymphomatoid papulosis: immunohistochemical study. J Cutan Pathol. 2001;28:453-9 pubmed
    b>Pityriasis lichenoides et varioliformis acuta (PLEVA) and lymphomatoid papulosis (LyP) are benign self-healing cutaneous eruptions that may be clinically and histologically similar...
  7. Pasic S, Pavlovic M, Vojvodic D, Abinun M. Pityriasis lichenoides in a girl with the granulomatous form of common variable immunodeficiency. Pediatr Dermatol. 2002;19:56-9 pubmed
    b>Pityriasis lichenoides (PL) is a cutaneous disease of unknown origin...
  8. Pinton P, Capezzera R, Zane C, De Panfilis G. Medium-dose ultraviolet A1 therapy for pityriasis lichenoides et varioliformis acuta and pityriasis lichenoides chronica. J Am Acad Dermatol. 2002;47:410-4 pubmed
    ..The purpose of the present study was to assess the efficacy of UVA1 phototherapy for pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC)...
  9. Menni S, Betti R, Cerri A, Crosti C. Pityriasis lichenoides chronica in a patient affected by multiple myeloma. J Eur Acad Dermatol Venereol. 2007;21:1144-5 pubmed

More Information

Publications62

  1. Magro C, Crowson A, Morrison C, Li J. Pityriasis lichenoides chronica: stratification by molecular and phenotypic profile. Hum Pathol. 2007;38:479-90 pubmed
    b>Pityriasis lichenoides (PL) has traditionally been classified as a benign papulosquamous disease...
  2. Skinner R, Levy A. Rapid resolution of pityriasis lichenoides et varioliformis acuta with azithromycin. J Am Acad Dermatol. 2008;58:524-5 pubmed publisher
  3. Leung A, Robson W. Picture of the month. Pityriasis lichenoides et varioliformis acuta. Arch Pediatr Adolesc Med. 2005;159:978-9 pubmed
  4. Hantz Doffoel V, Fauchais A, Sparsa A, Soria P, Bezanahary H, Ly K, et al. [BIOTOX alert: Jack in the box?]. Rev Med Interne. 2005;26 Suppl 2:S249-50 pubmed
  5. Nair P. A clinical and histopathological study of pityriasis lichenoides. Indian J Dermatol Venereol Leprol. 2007;73:100-2 pubmed
    b>Pityriasis lichenoides is a papulosquamous disorder of unknown etiology with remissions and exacerbations. Histopathology helps greatly in the diagnosis of this condition...
  6. Lam J, Pope E. Pediatric pityriasis lichenoides and cutaneous T-cell lymphoma. Curr Opin Pediatr. 2007;19:441-5 pubmed
    ..of this review is to educate the reader about two cutaneous lymphoproliferative diseases in childhood: pityriasis lichenoides and cutaneous T-cell lymphoma...
  7. Maranda E, Smith M, Nguyen A, Patel V, Schachner L, Joaquin J. Phototherapy for Pityriasis Lichenoides in the Pediatric Population: A Review of the Published Literature. Am J Clin Dermatol. 2016;17:583-591 pubmed
    b>Pityriasis lichenoides (PL) is a dermatologic disorder that manifests in either the acute (pityriasis lichenoides et varioliformis acuta) or the chronic form (pityriasis lichenoides chronica, also known as parapsoriasis chronica)...
  8. Meziane L, Caudron A, Dhaille F, Jourdan M, Dadban A, Lok C, et al. Febrile ulceronecrotic Mucha-Habermann disease: treatment with infliximab and intravenous immunoglobulins and review of the literature. Dermatology. 2012;225:344-8 pubmed publisher
    Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a rare subtype of pityriasis lichenoides et varioliformis acuta, characterized by an acute onset of ulceronecrotic papules, rapidly coalescing into large ulcers with necrotic ..
  9. Aydingöz I, Kocaayan N, Mansur A, Pekcan S, Arman A. A case of ulceronecrotic Mucha-Habermann disease with pulmonary involvement. Dermatology. 2006;212:388-90 pubmed
  10. Bonvicini F, La Placa M, Manaresi E, Gallinella G, Gentilomi G, Zerbini M, et al. Parvovirus b19 DNA is commonly harboured in human skin. Dermatology. 2010;220:138-42 pubmed publisher
    ..B19 DNA was detected in 11/38 (28.9%) pityriasis lichenoides, 8/30 (26.7%) melanocytic naevi, 5/29 (17.2%) primary melanomas and 6/24 (25.0%) healthy skin biopsies...
  11. Tilly J, Drolet B, Esterly N. Lichenoid eruptions in children. J Am Acad Dermatol. 2004;51:606-24 pubmed
    ..Discontinuation of the medication is often sufficient for resolution of lichenoid drug eruptions. ..
  12. Tsai K, Hsieh H, Chow K, Lin T, Chiang S, Huang H. Detection of cytomegalovirus infection in a patient with febrile ulceronecrotic Mucha-Habermann's disease. Int J Dermatol. 2001;40:694-8 pubmed
    Febrile ulceronecrotic Mucha-Habermann's disease (FUMHD) is a severe and very rare variant of pityriasis lichenoides et varilioformis acuta, which is characterized by large coalescing, and ulceronecrotic maculopapules or plaques...
  13. Lin C, Cook J, Purvis D. Febrile ulceronecrotic Mucha-Habermann disease: a case with systemic symptoms managed with subcutaneous methotrexate. Australas J Dermatol. 2012;53:e83-6 pubmed publisher
    ..Through our literature review, we also explore treatment protocols for a disease for which internationally standardized management is yet to be formulated. ..
  14. Lis Święty A, Michalska Bańkowska A, Zielonka Kucharzewska A, Pypłacz Gumprecht A. Successful therapy of cyclosporin A in pityriasis lichenoides et varioliformis acuta preceded by hand, foot and mouth disease. Antivir Ther. 2016;21:273-5 pubmed publisher
    To our knowledge, there are no previously published cases of enteroviral infection complicated by pityriasis lichenoides et varioliformis acuta (PLEVA)...
  15. Nassef N, Hammam M. The relation between toxoplasmosis and pityriasis lichenoides chronica. J Egypt Soc Parasitol. 1997;27:93-9 pubmed
    b>Pityriasis lichenoides chronica (PLC) is a rare skin disease of uncertain aetiology. Many infectious agents have been incriminated as the cause of the disease. One of these agents is toxoplasmosis...
  16. Miyamoto T, Takayama N, Kitada S, Hagari Y, Mihara M. Febrile ulceronecrotic Mucha-Habermann disease: a case report and a review of the literature. J Clin Pathol. 2003;56:795-7 pubmed
    ..FUMHD is a very rare, febrile variant type of pityriasis lichenoides et varioliformis acuta, and is characterised by necrotic cutaneous ulcerations associated with high fever ..
  17. Pyrpasopoulou A, Athyros V, Karagiannis A, Chrysomallis F, Zamboulis C. Intravenous immunoglobulins: a valuable asset in the treatment of a case of septic febrile ulceronecrotic Mucha-Habermann disease. Dermatology. 2007;215:164-5 pubmed
  18. Zegpi M, Ruiz F, Porras N. [Pityriasis Lichenoides: Case report and review of the literature]. Rev Chil Pediatr. 2015;86:121-5 pubmed publisher
    b>Pityriasis lichenoides is a benign inflammatory disease of unknown etiology...
  19. Jowkar F, Namazi M, Bahmani M, Monabati A. Triggering of pityriasis lichenoides et varioliformis acuta by radiocontrast iodide. J Dermatolog Treat. 2008;19:249-50 pubmed publisher
    b>Pityriasis lichenoides et varioliformis acuta (PLEVA) is characterized by 2-3 mm erythematous papules that became vesiculopustular with hemorrhagic necrosis...
  20. Wahie S, Hiscutt E, Natarajan S, Taylor A. Pityriasis lichenoides: the differences between children and adults. Br J Dermatol. 2007;157:941-5 pubmed
    b>Pityriasis lichenoides (PL) is a skin disease that affects both children and adults. Anecdotally, it is said to run a more benign course in children, with a frequent tendency to self-resolution...
  21. Simonetti G, Lang K, Schöni M. [Persistent skin eruption after adenovirus infection]. Praxis (Bern 1994). 2003;92:1361-3 pubmed
  22. Doffoel Hantz V, Fauchais A, Sparsa A, Roux C, Ly K, Loustaud Ratti V, et al. [Abrupt onset of papulovesicular lesions: diagnostic features and outcome]. Rev Med Interne. 2007;28:127-30 pubmed
    ..Febrile ulceronecrotic Mucha-Habermann disease is an unusual severe form of pityriasis lichenoides and varioliform acuta (PLEVA) characterized with ulceronecrotic eruption potentially associated with high ..
  23. Kadin M. T-cell clonality in pityriasis lichenoides: evidence for a premalignant or reactive immune disorder?. Arch Dermatol. 2002;138:1089-90 pubmed
  24. Sharon V, Konia T, Barr K, Fung M. Assessment of the 'no eosinophils' rule: are eosinophils truly absent in pityriasis lichenoides, connective tissue disease, and graft-vs.-host disease?. J Cutan Pathol. 2012;39:413-8 pubmed publisher
    ..dermatitis with clinically confirmed diagnoses, including lupus erythematosus (LE), lichen planus, pityriasis lichenoides (PL), graft-vs.-host disease (GVHD), dermatomyositis (DM) and drug reaction...
  25. Dupin A, Bosset D, Atger L, Chevallier B, Saiag P, Benoist G. [Febrile ulceronecrotic Mucha-Habermann disease]. Arch Pediatr. 2016;23:82-5 pubmed publisher
    b>Pityriasis lichenoides et varioliformis acuta (PLEVA) is an inflammatory skin disease that is unknown to pediatricians. The ulceronecrotic febrile form is a rare and potentially lethal variant...
  26. Khosrotehrani K, Guegan S, Fraitag S, Oster M, De Prost Y, Bodemer C, et al. Presence of chimeric maternally derived keratinocytes in cutaneous inflammatory diseases of children: the example of pityriasis lichenoides. J Invest Dermatol. 2006;126:345-8 pubmed
    ..The fate of these cells remains unknown. As unexplained T-cell-mediated conditions such as pityriasis lichenoides (PL) may occur in children, we aimed at identifying maternal cells in lesional skin of PL and controls...
  27. Plaza J, Morrison C, Magro C. Assessment of TCR-beta clonality in a diverse group of cutaneous T-Cell infiltrates. J Cutan Pathol. 2008;35:358-65 pubmed
    ..immunophenotypic and molecular abnormalities to those of malignant lymphoma can also be observed in pityriasis lichenoides chronica (PLC), large plaque parapsoriasis (LPP), pigmented purpuric dermatosis (PPD) and atypical ..
  28. Massimiliano R, Pietro R, Paolo S, Sara P, Michele F. Role of bromelain in the treatment of patients with pityriasis lichenoides chronica. J Dermatolog Treat. 2007;18:219-22 pubmed
    b>Pityriasis lichenoides chronica (PLC) is a skin disease of unknown etiology. Uncertainty about the etiopathogenesis of this skin disease is the reason for the unpredictable and non optimal efficacy of therapies available for its treatment...
  29. Salman A, Gencosmanoglu D, Yücelten A, Elcioglu N, Richard G, Demirkesen C. Successful treatment of pityriasis lichenoides chronica with narrow-band ultraviolet B therapy in a patient with Keratitis-Ichthyosis-Deafness syndrome: a case report. Dermatol Online J. 2016;22: pubmed
    ..Herein, we report a patient with this rare syndrome in association with pityriasis lichenoides chronica, which was succesfully treated with narrow-band ultraviolet B phototherapy despite our concerns ..
  30. Vonderheid E, Kadin M, Gocke C. Lymphomatoid papulosis followed by pityriasis lichenoides: a common pathogenesis?. Am J Dermatopathol. 2011;33:835-40 pubmed publisher
    b>Pityriasis lichenoides (PL) and lymphomatoid papulosis (LyP) are uncommon idiopathic eruptions with overlapping clinical and histological features...
  31. Pfistershammer K, Petzelbauer P, Stingl G, Mastan P, Chott A, Jager U, et al. Methotrexate-induced primary cutaneous diffuse large B-cell lymphoma with an 'angiocentric' histological morphology. Clin Exp Dermatol. 2010;35:59-62 pubmed publisher
    ..The rapid course of lesion development and regression was reminiscent of pityriasis lichenoides. Histology revealed a nodular infiltrate composed of a mixture of pleomorphic large B cells positive for ..
  32. Cumming M, Salathiel A, Paino M, Delort S, Roselino A. [Febrile ulceronecrotic Mucha-Habermann disease with exuberant mucosal involvement: case report]. An Bras Dermatol. 2009;84:655-8 pubmed
    b>Pityriasis lichenoides is a rare idiopathic cutaneous disorder, with a clinical-histopathological spectrum comprising the acute varioliform form (Mucha-Habermann's disease), its febrile ulceronecrotic variant, and its chronic form...
  33. Wang S, Hsiao C, Hsiao P, Chu C. Adult pityriasis lichenoides-like mycosis fungoides with high density of CD8-positive T-lymphocytic infiltration. J Eur Acad Dermatol Venereol. 2007;21:401-2 pubmed
  34. Fernandez Guarino M, Harto A, Reguero Callejas M, Urrutia S, Jaen P. Pityriasis lichenoides chronica: good response to photodynamic therapy. Br J Dermatol. 2008;158:198-200 pubmed
  35. Ito N, Ohshima A, Hashizume H, Takigawa M, Tokura Y. Febrile ulceronecrotic Mucha-Habermann's disease managed with methylprednisolone semipulse and subsequent methotrexate therapies. J Am Acad Dermatol. 2003;49:1142-8 pubmed
    Febrile ulceronecrotic Mucha-Habermann's disease is an unusual severe form of pityriasis lichenoides et varioliformis acuta characterized by abrupt onset of ulceronecrotic eruption associated with a high fever and systemic symptoms...
  36. Perrin B, Yan A, Treat J. Febrile ulceronecrotic Mucha-Habermann disease in a 34-month-old boy: a case report and review of the literature. Pediatr Dermatol. 2012;29:53-8 pubmed publisher
    ..Our patient had a history of biopsy-proven pityriasis lichenoides et varioliformis acuta (PLEVA) since age 2...
  37. Nassif P, Godoy D, Nakandakari S, Alves C, Soares C. Febrile ulceronecrotic Mucha-Habermann disease in adult patient successfully treated with systemic corticosteroid. An Bras Dermatol. 2010;85:891-4 pubmed
    The Febrile Ulceronecrotic Mucha-Habermann (FUMHD) disease is a rare variant of pityriasis lichenoides et varioliformis acuta (PLEVA)...
  38. Mallipeddi R, Evans A. Refractory pityriasis lichenoides chronica successfully treated with topical tacrolimus. Clin Exp Dermatol. 2003;28:456-8 pubmed
  39. Alratrout J, Alshammasi F, Ansari N. Febrile ulceronecrotic Mucha-Habermann disease in an 8-year-old boy responding to methotrexate. Int J Dermatol. 2016;55:1205-1209 pubmed publisher
    Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a rare fulminant variant of pityriasis lichenoides et varioliformis acuta (PLEVA) characterized by a rapidly progressive course with predominant ulceronecrotic lesions associated ..
  40. Cavelier Balloy B. [Pityriasis lichenoides]. Ann Dermatol Venereol. 2006;133:208-10 pubmed
  41. Solomon G, Magro C. Foxp3 expression in cutaneous T-cell lymphocytic infiltrates. J Cutan Pathol. 2008;35:1032-9 pubmed publisher
    ..host disease. The prelymphomatous dyscrasia category was represented chiefly by pityriasis lichenoides chronica (PLC) and pigmented purpuric dermatosis (PPD)...
  42. Hoshina D, Akiyama M, Hamasaka K, Shimizu H. An infantile case of pityriasis lichenoides et varioliformis acuta. Br J Dermatol. 2007;157:194-6 pubmed
  43. Costa Silva M, Calistru A, Sobrinho Simões J, Lisboa C, Azevedo F. Pitiryasis Lichenoides et Varioliformis Aacuta Associated With Human Herpesvirus 7. Actas Dermosifiliogr. 2018;109:e6-e10 pubmed publisher
    b>Pityriasis lichenoides et varioliformis acuta and pityriasis lichenoides chronica represent 2 ends of a disease spectrum of unknown etiology...
  44. Virdi S, Kanwar A, Saikia U. Pityriasis lichenoides with ulceronecrosis and hyperthermia: a rare variant of pityriasis lichenoides et varioliformis acuta. Indian J Dermatol Venereol Leprol. 2010;76:172-5 pubmed publisher
    b>Pityriasis lichenoides with ulceronecrosis and hyperthermia (PLUH) is a severe variant of pityriasis lichenoides et varioliformis acuta that is characterized by high fever and papulo-necrotic skin lesions...
  45. Lazaridou E, Fotiadou C, Tsorova C, Trachana M, Trigoni A, Patsatsi A, et al. Resistant pityriasis lichenoides et varioliformis acuta in a 3-year-old boy: successful treatment with methotrexate. Int J Dermatol. 2010;49:215-7 pubmed publisher
    b>Pityriasis lichenoides et varioliformis acuta (PLEVA) represents the acute clinical subtype of pityriasis lichenoides (PL) and its occurrence is relatively common during childhood...
  46. Di Giunta G, da Silva A, Sotto M. Inducible nitric oxide synthase in pityriasis lichenoides lesions. J Cutan Pathol. 2009;36:325-30 pubmed publisher
    b>Pityriasis lichenoides (PL) is an inflammatory skin disease of unknown etiology. Nitric oxide (NO) has emerged as an important mediator of many physiological functions...
  47. Kempf W, Kutzner H, Kettelhack N, Palmedo G, Burg G. Paraneoplastic pityriasis lichenoides in cutaneous lymphoma: case report and review of the literature on paraneoplastic reactions of the skin in lymphoma and leukaemia. Br J Dermatol. 2005;152:1327-31 pubmed
    ..We report for the first time two patients with pityriasis lichenoides et varioliformis acuta in association with mycosis fungoides...
  48. Fölster Holst R, Zawar V, Chuh A. [Paraviral exanthems]. Hautarzt. 2017;68:211-216 pubmed publisher
    ..Typical paraviral exanthems include Gianotti-Crosti syndrome, pityriasis rosea, pityriasis lichenoides, papular-purpuric gloves and sock syndrome, and asymmetrical periflexural exanthema...
  49. Farnaghi F, Seirafi H, Ehsani A, Agdari M, Noormohammadpour P. Comparison of the therapeutic effects of narrow band UVB vs. PUVA in patients with pityriasis lichenoides. J Eur Acad Dermatol Venereol. 2011;25:913-6 pubmed publisher
    b>Pityriasis lichenoides (PL) is a self-limiting papulosquamous skin disorder with chronic course. Best therapeutic options are yet to be defined...
  50. Boralevi F, Cotto E, Baysse L, Jouvencel A, Leaute Labreze C, Taieb A. Is varicella-zoster virus involved in the etiopathogeny of pityriasis lichenoides?. J Invest Dermatol. 2003;121:647-8 pubmed
  51. Cozzio A, Hafner J, Kempf W, Häffner A, Palmedo G, Michaelis S, et al. Febrile ulceronecrotic Mucha-Habermann disease with clonality: a cutaneous T-cell lymphoma entity?. J Am Acad Dermatol. 2004;51:1014-7 pubmed
    Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a severe variant of pityriasis lichenoides et varioliformis acuta (PLEVA)...
  52. Kaufman W, McNamara E, Curtis A, Kosari P, Jorizzo J, Krowchuk D. Febrile ulceronecrotic Mucha-Habermann disease (pityriasis lichenoides et varioliformis acuta fulminans) presenting as Stevens-Johnson syndrome. Pediatr Dermatol. 2012;29:135-40 pubmed publisher
    We present two pediatric patients with pityriasis lichenoides et varioliformis acuta fulminans whose admitting diagnosis was Stevens Johnson Syndrome. The patients were successfully treated with methotrexate and prednisone...
  53. Garcia B, Connelly E, Newbury R, Friedlander S. Pityriasis lichenoides and idiopathic thrombocytopenic purpura in a young girl. Pediatr Dermatol. 2006;23:21-3 pubmed
    b>Pityriasis lichenoides is an inflammatory skin disorder characterized by erythematous, desquamative papules and plaques...