cholesteatoma

Summary

Summary: A non-neoplastic mass of keratin-producing squamous EPITHELIUM, frequently occurring in the MENINGES; bones of the skull, and most commonly in the MIDDLE EAR and MASTOID region. Cholesteatoma can be congenital or acquired. Cholesteatoma is not a tumor nor is it associated with high CHOLESTEROL.

Top Publications

  1. Persaud R, Hajioff D, Thevasagayam M, Wareing M, Wright A. Keratosis obturans and external ear canal cholesteatoma: how and why we should distinguish between these conditions. Clin Otolaryngol Allied Sci. 2004;29:577-81 pubmed
    ..We concur that external ear canal cholesteatoma and keratosis obturans are different conditions and conclude that the presence of osteonecrosis and focal ..
  2. Lee D. Intradiploic epidermoid cyst of the temporal bone: is it the same as or different from cholesteatoma?. J Craniofac Surg. 2011;22:1973-5 pubmed publisher
    ..I also describe the unique radiologic findings of my case, which differed from those of cholesteatoma.
  3. Stankovic M. Audiologic results of surgery for cholesteatoma: short- and long-term follow-up of influential factors. Otol Neurotol. 2008;29:933-40 pubmed publisher
    To review the audiologic results in a cohort of patients surgically treated for cholesteatoma.
  4. Feuillet L, Carvajal J, Sudre I, Pelletier J, Thomassin J, Drancourt M, et al. First isolation of Bacteroides thetaiotaomicron from a patient with a cholesteatoma and experiencing meningitis. J Clin Microbiol. 2005;43:1467-9 pubmed
    A 45-year-old man with a cholesteatoma experienced purulent meningitis. Microbial analysis of cerebrospinal fluid yielded in pure culture a gram-negative bacillus...
  5. Wilson K, Hoggan R, Shelton C. Tympanoplasty with intact canal wall mastoidectomy for cholesteatoma: long-term surgical outcomes. Otolaryngol Head Neck Surg. 2013;149:292-5 pubmed publisher
    With different mastoidectomy approaches available to the surgeon for treatment of cholesteatoma, we review long-term outcomes of intact canal wall (ICW) mastoidectomy with tympanoplasty.
  6. Giannuzzi A, Merkus P, Taibah A, Falcioni M. Congenital mastoid cholesteatoma: case series, definition, surgical key points, and literature review. Ann Otol Rhinol Laryngol. 2011;120:700-6 pubmed
    We evaluate 3 new cases of congenital cholesteatoma confined to the mastoid process, and compare them with cases presented in the literature in order to better define this rare lesion.
  7. Stankovic M. Applicability of autologous incus: the influence of age and localization of cholesteatoma. Eur Arch Otorhinolaryngol. 2007;264:995-8 pubmed
    There is a correlation between macroscopic and histologic changes of incus in chronic otitis with cholesteatoma. The incidence and types of damage of auditory ossicles in chronic otitis media were extensively studied, but except some ..
  8. Rothschild S, Ciernik I, Hartmann M, Schuknecht B, Lütolf U, Huber A. Cholesteatoma triggering squamous cell carcinoma: case report and literature review of a rare tumor. Am J Otolaryngol. 2009;30:256-60 pubmed publisher
    The aim of this study was to report a case of squamous cell carcinoma of the petrous part of the temporal bone associated with a long history of secondary acquired cholesteatoma in a 71-year-old man.
  9. Friedland D, Eernisse R, Erbe C, Gupta N, Cioffi J. Cholesteatoma growth and proliferation: posttranscriptional regulation by microRNA-21. Otol Neurotol. 2009;30:998-1005 pubmed publisher
    The goal of this study was to identify novel regulatory mechanisms controlling the growth and proliferation of cholesteatoma. Specifically, the potential role of microRNAs, regulators of protein translation, was studied in cholesteatoma...

More Information

Publications62

  1. Tsai C, Guo Y, Tsai T, Shiao A. Zygomatic abscess complicating a huge mastoid cholesteatoma with intact eardrum. Otolaryngol Head Neck Surg. 2003;128:436-8 pubmed
  2. Hansen S, Sørensen C, Stage J, Mouritzen A, Caye Thomasen P. Massive cholesteatoma of the frontal sinus: case report and review of the literature. Auris Nasus Larynx. 2007;34:387-92 pubmed
    A case of a massive cholesteatoma of the frontal sinus in an 80-year-old female is reported. This lesion is very uncommon and a review of the English literature revealed only 12 reported cases...
  3. Palacios E, Robertson H. Cholesteatoma of the maxillary sinus. Ear Nose Throat J. 2005;84:758 pubmed
  4. Raffa S, Leone L, Scrofani C, Monini S, Torrisi M, Barbara M. Cholesteatoma-associated fibroblasts modulate epithelial growth and differentiation through KGF/FGF7 secretion. Histochem Cell Biol. 2012;138:251-69 pubmed publisher
    ..The middle ear cholesteatoma, an aural epidermal pathology characterized by keratinocyte hyperproliferation and chronic inflammation, may ..
  5. Naim R, Riedel F, Hormann K. Expression of vascular endothelial growth factor in external auditory canal cholesteatoma. Int J Mol Med. 2003;11:555-8 pubmed
    External ear canal cholesteatoma (EACC) is an invasive and destructive chronic inflammation based on the uncontrolled proliferation of the keratinocytes with an osteolytic character predominantly present in the inferior part of the ..
  6. Hilton C, Ondrey F, Wuertz B, Levine S. Interleukin-8 production in response to tumor necrosis factor-alpha by cholesteatoma keratinocytes in cell culture. Laryngoscope. 2011;121:372-4 pubmed publisher
    Keratinocytes harvested from acquired cholesteatoma and grown in cell culture will demonstrate increased interleukin-8 (IL-8) production in response to tumor necrosis factor (TNF)-alpha as compared with a control keratinocyte cell line...
  7. Weber S, Kim J, Delashaw J, Wax M. Radial forearm free tissue transfer in the management of persistent cerebrospinal fluid leaks. Laryngoscope. 2005;115:968-72 pubmed
    ..Although numerous repair methods have been successful, the occasional patient develops a persistent leak. We describe our experience with free tissue transfer for repair of recalcitrant CSF leaks...
  8. McGuire J, Wasl H, Harris T, Copley G, Fagan J. Management of pediatric cholesteatoma based on presentations, complications, and outcomes. Int J Pediatr Otorhinolaryngol. 2016;80:69-73 pubmed publisher
    To highlight important aspects and paradigms in the management of paediatric cholesteatoma in a developing world setting...
  9. Kornblut A, Wolff S, Fauci A. Ear disease in patients with Wegener's granulomatosis. Laryngoscope. 1982;92:713-7 pubmed
    ..Other pathologies included suppurative otitis, cholesteatoma, facial nerve paralyses, temporal bone granulomata, and sensory hearing losses...
  10. Marchioni D, Rubini A, Gonzalez Navarro M, Alicandri Ciufelli M, James A, Presutti L. Bilateral congenital cholesteatoma: Surgical treatment and considerations. Int J Pediatr Otorhinolaryngol. 2017;99:146-151 pubmed publisher
    To describe a multicenter study regarding surgical management of bilateral congenital cholesteatoma (BCC) and underline the importance of endoscopes in the management of this condition...
  11. Pardo Maza A, Lassaletta L, Ruiz Bravo E, Perez Mora R, Peñarrocha J, Gavilan J. Fibrous dysplasia of the temporal bone secondary to ear surgery: a case report. J Med Case Rep. 2015;9:129 pubmed publisher
    ..She had undergone a previous tympanoplasty at 7 years of age because of a cholesteatoma. At the time of that first surgery, no radiological or histological signs indicated a bone disorder...
  12. Omae K, Kanemaru S, Nakatani E, Kaneda H, Nishimura T, Tona R, et al. Regenerative treatment for tympanic membrane perforation using gelatin sponge with basic fibroblast growth factor. Auris Nasus Larynx. 2017;44:664-671 pubmed publisher
    ..who participated in this study, one who fulfilled the exclusion criteria and did not undergo TMRP and one with cholesteatoma were excluded from the efficacy analysis...
  13. Reis Rego Â, Santos M, Coutinho M, Feliciano T, Almeida E Sousa C. Is von Willebrand disease linked to cholesteatoma aetiology?. Med Hypotheses. 2017;100:43-45 pubmed publisher
    b>Cholesteatoma is a common clinical picture seen by otolaryngologists. The disease is characterised by an abnormal grow "of skin in the wrong place"...
  14. Sorour S, Mohamed N, Abdel Fattah M, Elbary M, El Anwar M. Bioglass reconstruction of posterior meatal wall after canal wall down mastoidectomy. Am J Otolaryngol. 2018;39:282-285 pubmed publisher
    ..To assess the results of PMW reconstruction after CWD mastoidectomy for cholesteatoma using bioactive glass (BAG) that is fabricated and built up intraoperatively...
  15. Vanden Abeele D, Offeciers F. Management of labyrinthine fistulas in cholesteatoma. Acta Otorhinolaryngol Belg. 1993;47:311-21 pubmed
    Surgical management of labyrinthine fistulas caused by cholesteatoma remains controversial. In 213 patients with middle ear surgery for cholesteatoma, 18 patients (18 ears-8.5%) presented a labyrinthine fistula...
  16. Seven H, Coskun B, Calis A, Sayin I, Turgut S. Intracranial abscesses associated with chronic suppurative otitis media. Eur Arch Otorhinolaryngol. 2005;262:847-51 pubmed
    ..All patients were treated with intravenous antibiotics and canal wall down mastoidectomy. Cholesteatoma with granulation tissue and bony defects at the sinus plate and/or dural plate were seen in most of the ..
  17. Spielmann P, McKean S, White R, Hussain S. Surgical management of external auditory canal lesions. J Laryngol Otol. 2013;127:246-51 pubmed publisher
    ..emphasises the diagnostic differences between exostoses and osteomas, and between external auditory canal cholesteatoma and keratosis obturans...
  18. Quaranta N, Chang P, Baguley D, Moffat D. Audiologic presentation of cerebellopontine angle cholesteatoma. J Otolaryngol. 2003;32:217-21 pubmed
    The aim of this study was to examine the audiologic presentation of patients with cerebellopontine angle (CPA) cholesteatoma. Retrospective case review. Neuro-otologic tertiary referral centre...
  19. Charachon R, Lejeune J. [Comparison between closed and open technique with muscular filling up in surgery of cholesteatoma of the middle ear. Long-term results]. Acta Otorhinolaryngol Belg. 1991;45:35-42 pubmed
    ..The same figure was observed for obliteration techniques in 1 or 2 stages: 1% at 1 year, 5 and 8.9% at 5 years and 5.8 and 5.2% at 10 years. The air-bone gaps were the same for closed techniques and obliteration techniques. ..
  20. Jung J, Pashia M, Nishimoto S, Faddis B, Chole R. A possible role for nitric oxide in osteoclastogenesis associated with cholesteatoma. Otol Neurotol. 2004;25:661-8 pubmed
    This study was designed to investigate the potential role of nitric oxide in cholesteatoma-induced bone resorption, in vitro and in vivo...
  21. Nakashimo Y, Fukushima N, Hirai T, Katagiri Y, Kubota K. [Clinical study of secondary cholesteatoma]. Nihon Jibiinkoka Gakkai Kaiho. 2012;115:1023-8 pubmed
    Acquired middle ear cholesteatoma is considered to be formed by retraction of the tympanic membrane...
  22. Chandra R, Palmer J. Epidermoids of the paranasal sinuses and beyond: endoscopic management. Am J Rhinol. 2006;20:441-4 pubmed
    Epidermoid tumors of the craniofacial skeleton are uncommon, with the exception of acquired cholesteatoma of the temporal bone. These lesions may be primary embryologic in origin or, less frequently, may be iatrogenic or posttraumatic...
  23. Altuna X, García L, Martínez Z, de Pinedo M. The role of subtotal petrosectomy in cochlear implant recipients. Eur Arch Otorhinolaryngol. 2017;274:4149-4153 pubmed publisher
    ..The reason for performing a subtotal petrosectomy was chronic otitis media with or without cholesteatoma, radical cavities from previous surgeries or electrode extrusion of previously implanted devices...
  24. Govindaraju R, Adaikappan M, Rajagopalan R. Baro-otolagia Secondary to Cholesteatoma. Aerosp Med Hum Perform. 2017;88:65-67 pubmed publisher
    ..We describe an unusual presentation of baro-otalgia in a pilot secondary to cholesteatoma obstructing the aditus despite normal middle ear pressure equalization provided by a grommet in the ear...
  25. Maroldi R, Farina D, Palvarini L, Marconi A, Gadola E, Menni K, et al. Computed tomography and magnetic resonance imaging of pathologic conditions of the middle ear. Eur J Radiol. 2001;40:78-93 pubmed
    ..Particularly, the precise extent of bone erosion associated with cholesteatoma is correctly demonstrated by high resolution CT...
  26. Akdoğan M, Hızal E, Yılmaz S, Yavuz H, Yılmazer C, Canpolat T, et al. [Our surgical treatment results in pediatric cholesteatoma]. Kulak Burun Bogaz Ihtis Derg. 2015;25:224-8 pubmed publisher
    This study aims to evaluate surgical techniques and obtained outcomes in pediatric cholesteatoma. A total of 62 patients (41 males, 21 females; mean age 13 years; range 3 to 17 years) diagnosed as pediatric cholesteatoma between January ..
  27. Sarcu D, Isaacson G. Long-term Results of Endoscopically Assisted Pediatric Cholesteatoma Surgery. Otolaryngol Head Neck Surg. 2016;154:535-9 pubmed publisher
    Routine endoscopic examination during primary surgery decreased the rate of residual cholesteatoma to 18% in our early experience...
  28. Spilsbury K, Ha J, Semmens J, Lannigan F. Cholesteatoma in cleft lip and palate: a population-based follow-up study of children after ventilation tubes. Laryngoscope. 2013;123:2024-9 pubmed publisher
    To investigate the association of cleft conditions and the development of secondary cholesteatoma following middle ear ventilation tube insertion (MEVTI) in children...
  29. Naim R, Shen T, Riedel F, Bran G, Sadick H, Hormann K. Regulation of apoptosis in external auditory canal cholesteatoma by hepatocyte growth factor/scatter factor. ORL J Otorhinolaryngol Relat Spec. 2005;67:45-50 pubmed
    ..The result is apoptosis, marked by formation of dead squamous cells and sequestered keratin debris on the apical side of the cholesteatoma.
  30. Zhou Q, Zhang H, Liu H. Adenoid cystic carcinoma of the external auditory canal associated with cholesteatoma in an 8-year-old girl. Int J Pediatr Otorhinolaryngol. 2013;77:150-2 pubmed publisher
    ..We report an 8-year-old girl with adenoid cystic carcinoma of the external auditory canal associated with cholesteatoma. At the time of diagnosis, the tumor had invaded the surrounding structures and metastasized to the lymph ..
  31. Makiishi Shimobayashi C, Tsujimura T, Iwasaki T, Kakihana M, Shimano K, Terada N, et al. Localization of osteopontin at calcification sites of cholesteatoma: possible role as a regulator of deposition of calcium phosphate in the middle ear. Auris Nasus Larynx. 2004;31:3-9 pubmed
    ..in the middle ear, we here examined whether or not OPN is localized at the calcification sites of cholesteatoma, which is clearly different from chronic otitis media in the pathogenesis...
  32. Ralli G, Magliulo G, Gagliardi M, Bruni A. Two cases of cholesteatoma behind intact tympanic membrane with embryogenetic anomalies. Acta Otorhinolaryngol Belg. 1987;41:1021-8 pubmed
    Two new interesting cases of cholesteatoma of the middle ear behind an intact tympanic membrane are presented in this report...
  33. Sheahan P, Blayney A, Sheahan J, Earley M. Sequelae of otitis media with effusion among children with cleft lip and/or cleft palate. Clin Otolaryngol Allied Sci. 2002;27:494-500 pubmed
    ..9 years, and mean age at latest follow-up was 9.6 years. The incidence of COM was 19%, and the incidence of cholesteatoma was 1.9%...
  34. Migirov L. Laterality of acquired cholesteatoma and handedness. Otol Neurotol. 2012;33:996-7 pubmed publisher
    To investigate a possible contribution of handedness to the development of unilateral acquired cholesteatoma. All patients with unilateral acquired cholesteatoma attending otorhinolaryngology clinic between August 2009 and February 2012 ..
  35. Rosito L, da Silva M, Selaimen F, Jung Y, Pauletti M, Jung L, et al. Characteristics of 419 patients with acquired middle ear cholesteatoma. Braz J Otorhinolaryngol. 2017;83:126-131 pubmed publisher
    b>Cholesteatoma is a destructive lesion that can result in life-threatening complications. Typically, it presents with hypoacusis and continuous otorrhea as symptoms...
  36. Abdul Aziz D, Kozin E, Lin B, Wong K, Shah P, Remenschneider A, et al. Temporal bone computed tomography findings associated with feasibility of endoscopic ear surgery. Am J Otolaryngol. 2017;38:698-703 pubmed publisher
    ..criteria to stratify patients for transcanal (TEES) or transmastoid endoscopic ear surgery for resection of cholesteatoma. We aim to determine 1) whether standard preoperative computed tomography (CT) findings are associated with ..
  37. Tuzcu G, Yardımcı A, Turna Ã, Göner R, AcıoÄŸlu E. [Importance of diffusion weighted magnetic resonance imaging at differentiation of cholesteatoma and granulation tissue in patients with chronic suppurative otitis media]. Kulak Burun Bogaz Ihtis Derg. 2015;25:255-65 pubmed publisher
    ..imaging (EP-DWI) in preoperative magnetic resonance imaging of patients with surgically corrected cholesteatoma and granulation tissue according to DWI and apparent diffusion coefficient (ADC) values...
  38. Rainsbury J, Whiteside O, Bottrill I. Traumatic facial nerve neuroma following mastoid surgery: a case report and literature review. J Laryngol Otol. 2007;121:601-5 pubmed
    ..We present a further case of traumatic facial nerve neuroma following surgery for cholesteatoma. We also review the literature and discuss the management of this condition.
  39. Tripathi P, Nautiyal S. Incidence and Preoperative Predictive Indicators of Incudal Necrosis in CSOM: A Prospective Study in a Tertiary Care Centre. Indian J Otolaryngol Head Neck Surg. 2017;69:459-463 pubmed publisher
    ..Patients group was divided into cholesteatoma and non cholesteatoma group...
  40. Crowson M, Ramprasad V, Chapurin N, Cunningham C, Kaylie D. Cost analysis and outcomes of a second-look tympanoplasty-mastoidectomy strategy for cholesteatoma. Laryngoscope. 2016;126:2574-2579 pubmed publisher
    To analyze cost and compare cholesteatoma recidivism and hearing outcomes with single-stage and second-look operative strategies. Retrospective review and cost analysis...
  41. Belcadhi M, Chahed H, Mani R, Bouzouita K. Therapeutic approaches to complicated cholesteatoma of the external auditory canal: a case of associated facial paresis. Ear Nose Throat J. 2010;89:E1-6 pubmed
    Spontaneous cholesteatoma of the external auditory canal (EAC) is an uncommon condition that is difficult to diagnose...
  42. Gadre A, Davies J. Cholesteatoma of the external auditory canal in an immunocompromised patient. Ear Nose Throat J. 2006;85:626 pubmed
  43. El Mghari G, Rafiq B, El Ansari N. [Epidermoid cyst in the sella turcica: about a case]. Pan Afr Med J. 2017;28:39 pubmed publisher
    Epidermoid cyst (EC) or cholesteatoma is a benign tumor, often of congenital origin, occurring in the sub-arachnoidian spaces. Its treatment is based on surgery...
  44. Castro Sousa A, Henriques V, Rodrigues J, Fonseca R. Ossiculoplasty in chronic otitis media: Surgical results and prognostic factors of surgical success. Acta Otorrinolaringol Esp. 2017;68:131-137 pubmed publisher
    ..We reviewed the results of 153 patients with COM (with cholesteatoma (COMC) and without cholesteatoma (COMWC)) who underwent ossiculoplasty between January of 2002 to December of ..
  45. Bugalho M, Domingues R. Uncommon association of cerebral meningioma, parathyroid adenoma and papillary thyroid carcinoma in a patient harbouring a rare germline variant in the CDKN1B gene. BMJ Case Rep. 2016;2016: pubmed publisher
    ..with meningioma, papillary thyroid carcinoma, parathyroid adenoma and, additionally, Hürthle cell adenoma, cholesteatoma and uterine leiomyomas...
  46. Ching H, Spinner A, Ng M. Pediatric tympanic membrane cholesteatoma: Systematic review and meta-analysis. Int J Pediatr Otorhinolaryngol. 2017;102:21-27 pubmed publisher
    Tympanic membrane cholesteatoma (TMC) is a rare anomaly found in pediatric patients with no significant otologic history. Its pathogenesis appears distinct from congenital mesotympanic cholesteatoma...
  47. Di Lella F, Bacciu A, Pasanisi E, Ruberto M, D Angelo G, Vincenti V. Clinical findings and surgical results of middle ear cholesteatoma behind an intact tympanic membrane in adults. Acta Biomed. 2016;87:64-9 pubmed
    b>Cholesteatoma usually arises in the middle ear by the formation of a retraction pocket or a tympanic membrane perforation...
  48. Kuo C, Shiao A, Chen C, Lien C. Multidimensional staging system for pediatric acquired cholesteatoma: A 30-year verification data. Auris Nasus Larynx. 2016;43:387-94 pubmed publisher
    This article presents a points-based prognostic prediction model for pediatric acquired cholesteatoma, incorporating the multidimensional factors that contribute to surgical failure...
  49. Cüreoglu A, Osma U, Oktay M, Nazaroglu H, Meric F, Topcu I. Congenital cholesteatoma of the mastoid region. J Laryngol Otol. 2000;114:779-80 pubmed
    Congenital cholesteatoma may arise in the petrous apex, mastoid, middle ear, or external auditory canal. The least common site being the mastoid process...
  50. König J, Pannek J, Kickuth R, Noldus J. Late recurrence of renal cholesteatoma after 15 years. Urology. 2004;64:808-9 pubmed
    We report a late recurrence of a cholesteatoma of the left kidney after 15 years. Both the initial case and the recurrence were treated by endourologic and percutaneous approaches.
  51. Hiraumi H, Kanemaru S, Miura M, Yamamoto N, Sakamoto T, Ito J. Histopathological evaluation and long-term results of soft tissue preservation technique in cholesteatoma surgery. Eur Arch Otorhinolaryngol. 2017;274:711-714 pubmed publisher
    The goal of cholesteatoma surgery is total removal of the cholesteatoma matrix and prevention of recurrence. Preservation of soft tissue in the attic is reported to improve post-operative middle ear aeration, and thus prevents recurrence...
  52. Urík M, Hurník P, Ziak D, Machac J, Slapak I, Motyka O, et al. Histological analysis of retraction pocket pars tensa of tympanic membrane in children. Int J Pediatr Otorhinolaryngol. 2016;86:213-7 pubmed publisher
    ..Identification of signs typical for cholesteatoma and support for a retraction theory of cholesteatoma formation...
  53. Stevens S, Walters Z, Tawfik K, Samy R. Two Consecutive Cases of Persistent Stapedial Artery Managed With a Carbon Dioxide Laser. Ann Otol Rhinol Laryngol. 2017;:3489417742921 pubmed publisher
    1) Discuss the presentation and management of persistent stapedial artery (PSA) discovered incidentally during cholesteatoma surgery...