proteinuria

Summary

Summary: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.

Top Publications

  1. Houmsou R, Kela S, Suleiman M. Performance of microhaematuria and proteinuria as measured by urine reagent strips in estimating intensity and prevalence of Schistosoma haematobium infection in Nigeria. Asian Pac J Trop Med. 2011;4:997-1000 pubmed publisher
    To assess if microhaematuria and proteinuria as measured by reagent strips could estimate intensity of Schistosoma haematobium (S...
  2. Dondo V, Mujuru H, Nathoo K, Chirehwa M, Mufandaedza Z. Renal abnormalities among HIV-infected, antiretroviral naive children, Harare, Zimbabwe: a cross-sectional study. BMC Pediatr. 2013;13:75 pubmed publisher
    ..We set out to determine the prevalence of proteinuria; low estimated glomerular filtration rate (eGFR), urinary tract infection and associated factors among HIV-..
  3. Fyfe J, Hemker S, Venta P, Fitzgerald C, Outerbridge C, Myers S, et al. An exon 53 frameshift mutation in CUBN abrogates cubam function and causes Imerslund-Gräsbeck syndrome in dogs. Mol Genet Metab. 2013;109:390-6 pubmed publisher
    Cobalamin malabsorption accompanied by selective proteinuria is an autosomal recessive disorder known as Imerslund-Gräsbeck syndrome in humans and was previously described in dogs due to amnionless (AMN) mutations...
  4. Kang S, Cho K, Park J, Yoon K, Do J. Proteinuria as a risk factor for decline in residual renal function in non-diabetic peritoneal dialysis patients. Kidney Blood Press Res. 2013;37:199-210 pubmed publisher
    Preservation of residual renal function (RRF) is a major issue for patients on peritoneal dialysis (PD). Whether proteinuria is associated with a decline in RRF in patients on PD remains unclear.
  5. Nagata M, Ninomiya T, Kiyohara Y, Murakami Y, Irie F, Sairenchi T, et al. Prediction of cardiovascular disease mortality by proteinuria and reduced kidney function: pooled analysis of 39,000 individuals from 7 cohort studies in Japan. Am J Epidemiol. 2013;178:1-11 pubmed publisher
    There are limited studies addressing whether proteinuria and estimated glomerular filtration rate (eGFR) are independently associated with cardiovascular disease in Asia...
  6. Yokoyama H, Araki S, Honjo J, Okizaki S, Yamada D, Shudo R, et al. Association between remission of macroalbuminuria and preservation of renal function in patients with type 2 diabetes with overt proteinuria. Diabetes Care. 2013;36:3227-33 pubmed publisher
    ..Studies on the rate of remission of macroalbuminuria in patients with type 2 diabetes mellitus (T2DM) and the effects of reduction in albuminuria on renal prognosis in a primary care setting are absolutely lacking...
  7. Hofstra J, Fervenza F, Wetzels J. Treatment of idiopathic membranous nephropathy. Nat Rev Nephrol. 2013;9:443-58 pubmed publisher
    ..suggests that immunosuppressive therapy should be restricted to patients with nephrotic syndrome and persistent proteinuria, deteriorating renal function or severe symptoms...
  8. Takeda N, Kume S, Tanaka Y, Morita Y, Chin Kanasaki M, Araki H, et al. Altered unfolded protein response is implicated in the age-related exacerbation of proteinuria-induced proximal tubular cell damage. Am J Pathol. 2013;183:774-85 pubmed publisher
    ..We analyzed the mechanism involved in age-related exacerbation of proteinuria-induced proximal tubular cell (PTC) damage by focusing on endoplasmic reticulum-related unfolded protein ..
  9. Chen S, Hung C, Tsai Y, Huang J, Kuo M, Lee J, et al. Association of cholesterol levels with mortality and cardiovascular events among patients with CKD and different amounts of proteinuria. Clin J Am Soc Nephrol. 2013;8:1915-26 pubmed publisher
    ..However, it is unclear whether the relationship of total cholesterol with cardiovascular events and mortality varies by proteinuria.

More Information

Publications106 found, 100 shown here

  1. Yamahara K, Kume S, Koya D, Tanaka Y, Morita Y, Chin Kanasaki M, et al. Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions. J Am Soc Nephrol. 2013;24:1769-81 pubmed publisher
    ..We therefore examined the role of autophagy in obesity-mediated exacerbation of proteinuria-induced proximal tubular epithelial cell damage in mice and in human renal biopsy specimens...
  2. Pierantozzi M, Roura X, Paltrinieri S, Poggi M, Zatelli A. Variation of proteinuria in dogs with leishmaniasis treated with meglumine antimoniate and allopurinol: a retrospective study. J Am Anim Hosp Assoc. 2013;49:231-6 pubmed publisher
    ..study was performed using 53 client owned dogs with leishmaniasis to determine whether the degree of proteinuria, evaluated by the urine protein/creatinine ratio (UP/C), changes following treatment with meglumine antimoniate ..
  3. Muneyuki T, Sugawara H, Suwa K, Oshida H, Saito M, Hori Y, et al. A community-based cross-sectional and longitudinal study uncovered asymptomatic proteinuria in Japanese adults with low body weight. Kidney Int. 2013;84:1254-61 pubmed publisher
    Although proteinuria is highly prevalent in obese individuals, the association between proteinuria and low body weight is equivocal...
  4. Turin T, James M, Ravani P, Tonelli M, Manns B, Quinn R, et al. Proteinuria and rate of change in kidney function in a community-based population. J Am Soc Nephrol. 2013;24:1661-7 pubmed publisher
    b>Proteinuria identifies patients at risk for adverse clinical outcomes, but it is unclear whether proteinuria correlates with the rate of renal decline...
  5. Wickman L, Afshinnia F, Wang S, Yang Y, Wang F, Chowdhury M, et al. Urine podocyte mRNAs, proteinuria, and progression in human glomerular diseases. J Am Soc Nephrol. 2013;24:2081-95 pubmed publisher
    ..In contrast, urine podocyte mRNAs did not increase in polycystic kidney disease. The association between proteinuria and podocyturia varied markedly by glomerular disease type: a high correlation in minimal-change disease and a ..
  6. Bramham K, Poli de Figueiredo C, Seed P, Briley A, Poston L, Shennan A, et al. Association of proteinuria threshold in pre-eclampsia with maternal and perinatal outcomes: a nested case control cohort of high risk women. PLoS ONE. 2013;8:e76083 pubmed publisher
    To evaluate occurrence of adverse maternal and perinatal outcomes with different thresholds of proteinuria (300-499 mg and ?500 mg/24 hours) in pre-eclamptic women, comparing outcomes against women with chronic and gestational ..
  7. Yu C, Fornoni A, Weins A, Hakroush S, Maiguel D, Sageshima J, et al. Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med. 2013;369:2416-23 pubmed publisher
    ..glomerulosclerosis (FSGS) (four with recurrent FSGS after transplantation and one with primary FSGS) and proteinuria with B7-1 immunostaining of podocytes in kidney-biopsy specimens...
  8. Zivko M, Kusec R, Galesic K. Impact of angiotensin-converting enzyme gene polymorphism on proteinuria and arterial hypertension. Coll Antropol. 2013;37:765-70 pubmed
    b>Proteinuria is the hallmark of renal disease. In essential hypertension the onset of de novo proteinuria is associated with faster rate of progression of disease...
  9. de Borst M, Hajhosseiny R, Tamez H, Wenger J, Thadhani R, Goldsmith D. Active vitamin D treatment for reduction of residual proteinuria: a systematic review. J Am Soc Nephrol. 2013;24:1863-71 pubmed publisher
    Despite renin-angiotensin-aldosterone system blockade, which retards progression of CKD by reducing proteinuria, many patients with CKD have residual proteinuria, an independent risk factor for disease progression...
  10. McGovern A, de Lusignan S, van Vlymen J, Liyanage H, Tomson C, Gallagher H, et al. Serum phosphate as a risk factor for cardiovascular events in people with and without chronic kidney disease: a large community based cohort study. PLoS ONE. 2013;8:e74996 pubmed publisher
    ..We investigate this relationship in people with and without CKD in a large community-based population...
  11. Chatterjee R, Hoffman M, Cliften P, Seshan S, Liapis H, Jain S. Targeted exome sequencing integrated with clinicopathological information reveals novel and rare mutations in atypical, suspected and unknown cases of Alport syndrome or proteinuria. PLoS ONE. 2013;8:e76360 pubmed publisher
    ..reflux (VUR), recurrent urinary tract infections and hydronephrosis who presented with nephrotic range proteinuria at the age of 45...
  12. Clement L, Macé C, Avila Casado C, Joles J, Kersten S, Chugh S. Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome. Nat Med. 2014;20:37-46 pubmed publisher
    The molecular link between proteinuria and hyperlipidemia in nephrotic syndrome is not known...
  13. Taslipinar A, Yaman H, Yilmaz M, Demirbas S, Saglam M, Taslipinar M, et al. The relationship between inflammation, endothelial dysfunction and proteinuria in patients with diabetic nephropathy. Scand J Clin Lab Invest. 2011;71:606-12 pubmed publisher
    ..present study was to investigate the possible relationship between inflammation, endothelial dysfunction and proteinuria in patients with diabetic nephropathy...
  14. Conley J, Tonelli M, Quan H, Manns B, Palacios Derflingher L, Bresee L, et al. Association between GFR, proteinuria, and adverse outcomes among White, Chinese, and South Asian individuals in Canada. Am J Kidney Dis. 2012;59:390-9 pubmed publisher
    We investigated the association between proteinuria, estimated glomerular filtration rate (eGFR), and risk of mortality and kidney failure in white, Chinese, and South Asian populations. Population-based cohort study...
  15. Cohen A. Collagen Type III Glomerulopathies. Adv Chronic Kidney Dis. 2012;19:101-6 pubmed publisher
    ..b>Proteinuria is the typical manifestation, with progression to ESRD in approximately 10 years...
  16. Noborisaka Y, Ishizaki M, Nakata M, Yamada Y, Honda R, Yokoyama H, et al. Cigarette smoking, proteinuria, and renal function in middle-aged Japanese men from an occupational population. Environ Health Prev Med. 2012;17:147-56 pubmed publisher
    ..In 990 middle-aged men recruited from a chemical plant, proteinuria was measured by a dipstick method and the glomerular filtration rate was estimated (eGFR) using a formula ..
  17. Nakamura T, Sato E, Amaha M, Kawagoe Y, Maeda S, Yamagishi S. Addition of aliskiren to olmesartan ameliorates tubular injury in chronic kidney disease patients partly by reducing proteinuria. J Renin Angiotensin Aldosterone Syst. 2012;13:122-7 pubmed publisher
    ..Olmesartan or aliskiren monotherapy for 6 months comparably decreased blood pressure (BP) and proteinuria. BP and proteinuria levels were reduced more by combination therapy than by either monotherapy...
  18. Toyama K, Morisaki H, Cheng J, Kawachi H, Shimizu F, Ikawa M, et al. Proteinuria in AMPD2-deficient mice. Genes Cells. 2012;17:28-38 pubmed publisher
    ..In addition to changes in nucleotide metabolism in the kidneys, proteinuria was found in 3-week-old AMPD2 knockout mice, followed by a further increment up to a peak level at 6 weeks old (..
  19. Weir M, Townsend R, Fink J, Teal V, Anderson C, Appel L, et al. Hemodynamic correlates of proteinuria in chronic kidney disease. Clin J Am Soc Nephrol. 2011;6:2403-10 pubmed publisher
    Brachial artery measures of BP are associated with increasing degrees of proteinuria. Whether central measures of BP or vascular stiffness are associated with increased risk of proteinuria in patients with chronic kidney disease (CKD) is ..
  20. Forrest S, Kim A, Carbonella J, Pashankar F. Proteinuria is associated with elevated tricuspid regurgitant jet velocity in children with sickle cell disease. Pediatr Blood Cancer. 2012;58:937-40 pubmed publisher
    ..to determine if elevated pulmonary artery systolic pressures estimated on echocardiogram was associated with proteinuria in children with SCD...
  21. Vegter S, Perna A, Postma M, Navis G, Remuzzi G, Ruggenenti P. Sodium intake, ACE inhibition, and progression to ESRD. J Am Soc Nephrol. 2012;23:165-73 pubmed publisher
    ..the first and second Ramipril Efficacy in Nephropathy trials to evaluate the association of sodium intake with proteinuria and progression to ESRD among 500 CKD patients without diabetes who were treated with ramipril (5 mg/d) and ..
  22. Lankhorst S, Kappers M, van Esch J, Danser A, van den Meiracker A. Mechanism of hypertension and proteinuria during angiogenesis inhibition: evolving role of endothelin-1. J Hypertens. 2013;31:444-54; discussion 454 pubmed publisher
    ..This treatment is frequently associated with the development of hypertension and proteinuria. As VEGF increases the expression and the activity of nitric oxide synthase in endothelial cells, a decrease in ..
  23. Oltean S, Neal C, Mavrou A, Patel P, Ahad T, Alsop C, et al. VEGF165b overexpression restores normal glomerular water permeability in VEGF164-overexpressing adult mice. Am J Physiol Renal Physiol. 2012;303:F1026-36 pubmed publisher
    ..Persistent VEGF(164) overexpression did not cause proteinuria but did increase glomerular ultrafiltration coefficient between days 3 and 7...
  24. Cantarovich D, Perrone V. Pancreas transplant as treatment to arrest renal function decline in patients with type 1 diabetes and proteinuria. Semin Nephrol. 2012;32:432-6 pubmed publisher
    ..Third, all studies were observational in nature and clinical trials are needed to properly evaluate the effectiveness of normalization of hyperglycemia through PATx on postponing the onset of ESRD in type 1 diabetes. ..
  25. Xie C, Du Y, Kumar K, Li L, Han J, Liu K, et al. Lupus-prone strains vary in susceptibility to antibody-mediated end organ disease. Genes Immun. 2013;14:170-8 pubmed publisher
  26. Van Beneden K, Geers C, Pauwels M, Mannaerts I, Verbeelen D, van Grunsven L, et al. Valproic acid attenuates proteinuria and kidney injury. J Am Soc Nephrol. 2011;22:1863-75 pubmed publisher
    ..Administration of valproic acid before kidney injury prevented the development of proteinuria and the onset of glomerulosclerosis...
  27. Lee D, Kong J, Cho K, Chan L. Impact of vitamin D on proteinuria, insulin resistance, and cardiovascular parameters in kidney transplant recipients. Transplant Proc. 2011;43:3723-9 pubmed publisher
    Low vitamin D levels prevalent in patients with chronic kidney disease have been reported to be associated with proteinuria, insulin resistance, and cardiovascular disease...
  28. Oh S, Baek S, Kim Y, Goo H, Heo N, Na K, et al. Mild decrease in estimated glomerular filtration rate and proteinuria are associated with all-cause and cardiovascular mortality in the general population. Nephrol Dial Transplant. 2012;27:2284-90 pubmed publisher
    ..We analyzed the relationship of eGFR and proteinuria with mortality in the Korean general population, represented by 112,115 participants, aged ? 20 years, who had ..
  29. Cravedi P, Ruggenenti P, Remuzzi G. Proteinuria should be used as a surrogate in CKD. Nat Rev Nephrol. 2012;8:301-6 pubmed publisher
    ..The magnitude of proteinuria is widely recognized as a marker of the severity of glomerulopathy...
  30. Stelloh C, Allen K, Mattson D, Lerch Gaggl A, Reddy S, El Meanawy A. Prematurity in mice leads to reduction in nephron number, hypertension, and proteinuria. Transl Res. 2012;159:80-9 pubmed publisher
  31. Vasanwala F, Puvanendran R, Fook Chong S, Ng J, Suhail S, Lee K. Could peak proteinuria determine whether patient with dengue fever develop dengue hemorrhagic/dengue shock syndrome?--a prospective cohort study. BMC Infect Dis. 2011;11:212 pubmed publisher
    ..We explored whether proteinuria could be used as such a marker. We included patients admitted to hospital with suspected dengue fever...
  32. Zhang B, Xie S, Shi W, Yang Y. Amiloride off-target effect inhibits podocyte urokinase receptor expression and reduces proteinuria. Nephrol Dial Transplant. 2012;27:1746-55 pubmed publisher
    ..Amiloride has a significant role in the reduction of podocyte cell motility in vitro and proteinuria in mice...
  33. Yen T, Yang H, Yeh Y, Chu P, Wen C, Fu J, et al. Aliskiren attenuates proteinuria in mice with lupus nephritis by a blood pressure-independent mechanism. Lupus. 2013;22:180-9 pubmed publisher
    This study revealed that low-dose aliskiren treatment could attenuate proteinuria by interrupting the renin-angiotensin system in mice with lupus nephritis, and the beneficial effect was beyond blood pressure control...
  34. Gorriz J, Martinez Castelao A. Proteinuria: detection and role in native renal disease progression. Transplant Rev (Orlando). 2012;26:3-13 pubmed publisher
    The presence of albuminuria or proteinuria constitutes a sign of kidney damage and, together with the estimation of glomerular filtration rate, is based on the evaluation of chronic kidney disease...
  35. de Borst M, Nauta F, Vogt L, Laverman G, Gansevoort R, Navis G. Indomethacin reduces glomerular and tubular damage markers but not renal inflammation in chronic kidney disease patients: a post-hoc analysis. PLoS ONE. 2012;7:e37957 pubmed publisher
    Under specific conditions non-steroidal anti-inflammatory drugs (NSAIDs) may be used to lower therapy-resistant proteinuria. The potentially beneficial anti-proteinuric, tubulo-protective, and anti-inflammatory effects of NSAIDs may be ..
  36. Shafat I, Agbaria A, Boaz M, Schwartz D, Baruch R, Nakash R, et al. Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft function. PLoS ONE. 2012;7:e44076 pubmed publisher
    ..studies suggest a role for heparanase in several experimental and human glomerular diseases associated with proteinuria such as diabetes, minimal change disease, and membranous nephropathy...
  37. Liu W, Hsu C, Hsu Y. Chewing areca nut as an independent risk factor for proteinuria in middle-aged men. Kaohsiung J Med Sci. 2013;29:214-20 pubmed publisher
    No previous large-scale research has reported the association of chewing areca nut (AN) with proteinuria. The aim of this study was to investigate such an association in men over a 7-year study...
  38. Verghese P, Darrow S, Kurth M, Reed R, Kim Y, Kearney S. Successful management of factor IX inhibitor-associated nephrotic syndrome in a hemophilia B patient. Pediatr Nephrol. 2013;28:823-6 pubmed publisher
    ..Nephrotic syndrome (NS) is a recognized complication of immune tolerance induction (ITI) therapy, a treatment strategy used to treat inhibitors in patients with hemophilia B receiving factor IX concentrate...
  39. Kurdián M, Herrero Fresneda I, Lloberas N, Gimenez Bonafe P, Coria V, Grande M, et al. Delayed mTOR inhibition with low dose of everolimus reduces TGF? expression, attenuates proteinuria and renal damage in the renal mass reduction model. PLoS ONE. 2012;7:e32516 pubmed publisher
    ..3 mg/k/day) introduced 15 days after surgical procedure on renal function, proteinuria, renal histology and mechanisms of fibrosis and proliferation...
  40. Reznichenko A, Snieder H, van den Born J, de Borst M, Damman J, van Dijk M, et al. CUBN as a novel locus for end-stage renal disease: insights from renal transplantation. PLoS ONE. 2012;7:e36512 pubmed publisher
    ..the hypothesis that common genetic variants in CUBN are associated with end-stage renal disease (ESRD) and proteinuria. First, a total of 1142 patients with ESRD, admitted for renal transplantation, and 1186 donors were genotyped ..
  41. Ekulu P, Nseka N, Aloni M, Gini J, Makulo J, Lepira F, et al. [Prevalence of proteinuria and its association with HIV/AIDS in Congolese children living in Kinshasa, Democratic Republic of Congo]. Nephrol Ther. 2012;8:163-7 pubmed publisher
    ..This study aimed to determine the prevalence of proteinuria in Congolese children living in Kinshasa and to study its association with the HIV infection...
  42. Gong R. The renaissance of corticotropin therapy in proteinuric nephropathies. Nat Rev Nephrol. 2011;8:122-8 pubmed publisher
  43. Jotwani V, Li Y, Grunfeld C, Choi A, Shlipak M. Risk factors for ESRD in HIV-infected individuals: traditional and HIV-related factors. Am J Kidney Dis. 2012;59:628-35 pubmed publisher
    ..for ESRD in HIV-infected individuals and compare ESRD risk by estimated glomerular filtration rate (eGFR) and proteinuria levels. Retrospective cohort study...
  44. Rosansky S. Renal function trajectory is more important than chronic kidney disease stage for managing patients with chronic kidney disease. Am J Nephrol. 2012;36:1-10 pubmed publisher
    ..as calculated from the modification of diet in renal disease glomerulofiltration rate equations (eGFR) and proteinuria for staging of CKD...
  45. Yanagi M, Tamura K, Fujikawa T, Wakui H, Kanaoka T, Ohsawa M, et al. The angiotensin II type 1 receptor blocker olmesartan preferentially improves nocturnal hypertension and proteinuria in chronic kidney disease. Hypertens Res. 2013;36:262-9 pubmed publisher
    ..These results indicate that in hypertensive patients with CKD, olmesartan add-on therapy improves the ambulatory BP profile via a preferential reduction in nighttime BP with concomitant renal injury inhibition. ..
  46. Nishibori Y, Katayama K, Parikka M, Oddsson A, Nukui M, Hultenby K, et al. Glcci1 deficiency leads to proteinuria. J Am Soc Nephrol. 2011;22:2037-46 pubmed publisher
    ..Taken together, these data suggest that Glcci1 promotes the normal development and maintenance of podocyte structure and function. ..
  47. Liu L, LV J, Shi S, Chen Y, Zhang H, Wang H. Oral calcitriol for reduction of proteinuria in patients with IgA nephropathy: a randomized controlled trial. Am J Kidney Dis. 2012;59:67-74 pubmed publisher
    Vitamin D has shown efficacy in the reduction of proteinuria in patients with chronic kidney disease. This study aimed to determine the effect of calcitriol on urinary protein excretion in patients with immunoglobulin A (IgA) nephropathy...
  48. Kalani A, Mohan A, Godbole M, Bhatia E, Gupta A, Sharma R, et al. Wilm's tumor-1 protein levels in urinary exosomes from diabetic patients with or without proteinuria. PLoS ONE. 2013;8:e60177 pubmed publisher
    ..Patients were divided based on their urinary albumin excretion, ACR (mg/g creatinine) into non- proteinuria group (ACR<30 mg/g, n?=?30) and proteinuria group (ACR>30 mg/g, n?=?18)...
  49. Payne B, Magee L, Côté A, Hutcheon J, Kyle P, Menzies J, et al. PIERS proteinuria: relationship with adverse maternal and perinatal outcome. J Obstet Gynaecol Can. 2011;33:588-597 pubmed publisher
    To examine the ability of three different proteinuria assessment methods (urinary dipstick, spot urine protein:creatinine ratio [Pr/Cr], and 24-hour urine collection) to predict adverse pregnancy outcomes...
  50. Finch J, Suarez E, Husain K, Ferder L, Cardema M, GLENN D, et al. Effect of combining an ACE inhibitor and a VDR activator on glomerulosclerosis, proteinuria, and renal oxidative stress in uremic rats. Am J Physiol Renal Physiol. 2012;302:F141-9 pubmed publisher
    ..8 ?g/kg ip, 3 × wk), or U+enalapril+paricalcitol (UEP). Despite hypertension in UP rats, proteinuria decreased by 32% vs. UC rats...
  51. Friedman D, Kozlitina J, Genovese G, Jog P, Pollak M. Population-based risk assessment of APOL1 on renal disease. J Am Soc Nephrol. 2011;22:2098-105 pubmed publisher
    ..In contrast, African Americans without the risk genotype and European Americans appear to have similar risk for developing nondiabetic CKD. ..
  52. Bomback A, Canetta P, Beck L, Ayalon R, Radhakrishnan J, Appel G. Treatment of resistant glomerular diseases with adrenocorticotropic hormone gel: a prospective trial. Am J Nephrol. 2012;36:58-67 pubmed publisher
    ..Adrenocorticotropic hormone (ACTH) has shown promising results in glomerular diseases resistant to conventional therapies, but the reported data have solely been from retrospective, observational studies...
  53. Beech C, Liyanarachchi S, Shah N, Sturm A, Sadiq M, de la Chapelle A, et al. Ancient founder mutation is responsible for Imerslund-Gräsbeck Syndrome among diverse ethnicities. Orphanet J Rare Dis. 2011;6:74 pubmed publisher
    ..Thus, rare founder mutations may cause a substantial number of cases, even among diverse ethnicities not usually thought to be related. ..
  54. Lehnhardt A, Lama A, Amann K, Matejas V, Zenker M, Kemper M. Pierson syndrome in an adolescent girl with nephrotic range proteinuria but a normal GFR. Pediatr Nephrol. 2012;27:865-8 pubmed publisher
    ..Pierson syndrome, caused by mutations in the LAMB2 gene, was originally described as a combination of microcoria and congenital nephrotic syndrome, rapidly progressing to end-stage renal failure...
  55. Koga T, Kai Y, Fukuda R, Morino Koga S, Suico M, Koyama K, et al. Mild electrical stimulation and heat shock ameliorates progressive proteinuria and renal inflammation in mouse model of Alport syndrome. PLoS ONE. 2012;7:e43852 pubmed publisher
    Alport syndrome is a hereditary glomerulopathy with proteinuria and nephritis caused by defects in genes encoding type IV collagen in the glomerular basement membrane. All male and most female patients develop end-stage renal disease...
  56. Robinson A, Thierry Palmer M, Gibson K, Rabinovich C. Disease activity, proteinuria, and vitamin D status in children with systemic lupus erythematosus and juvenile dermatomyositis. J Pediatr. 2012;160:297-302 pubmed publisher
    To evaluate relationships among vitamin D, proteinuria, and disease activity in pediatric systemic lupus erythematosus (SLE) and juvenile dermatomyositis (JDM).
  57. Estrella M, Kirk G, Mehta S, Brown T, Fine D, Atta M, et al. Vitamin D deficiency and persistent proteinuria among HIV-infected and uninfected injection drug users. AIDS. 2012;26:295-302 pubmed publisher
    b>Proteinuria occurs commonly among HIV-infected and uninfected injection drug users (IDUs) and is associated with increased mortality risk...
  58. Tanner S, Sturm A, Baack E, Liyanarachchi S, de la Chapelle A. Inherited cobalamin malabsorption. Mutations in three genes reveal functional and ethnic patterns. Orphanet J Rare Dis. 2012;7:56 pubmed publisher
    ..IGS and IFD differ in that IGS usually presents with proteinuria, which is not observed in IFD...
  59. Han T, Rong G, Quan D, Shu Y, Liang Z, She N, et al. Meta-analysis: the efficacy and safety of paricalcitol for the treatment of secondary hyperparathyroidism and proteinuria in chronic kidney disease. Biomed Res Int. 2013;2013:320560 pubmed publisher
    ..A secondary aim was to determine if sufficient data was available to assess the effect of Paricalcitol for the management of proteinuria.
  60. Modesti P, Bamoshmoosh M, Rapi S, Massetti L, Bianchi S, Al Hidabi D, et al. Relationship between hypertension, diabetes and proteinuria in rural and urban households in Yemen. J Hum Hypertens. 2013;27:572-9 pubmed publisher
    Little information is available on the meanings of proteinuria in low-resource settings...
  61. Maeda I, Hayashi T, Sato K, Koh H, Harita N, Nakamura Y, et al. Cigarette smoking and the association with glomerular hyperfiltration and proteinuria in healthy middle-aged men. Clin J Am Soc Nephrol. 2011;6:2462-9 pubmed publisher
    ..The degree of glomerular hyperfiltration and proteinuria associated with smoking, which presumably is a phenomenon of early renal damage, has not been investigated in a ..
  62. Kandula P, Agarwal R. Proteinuria and hypertension with tyrosine kinase inhibitors. Kidney Int. 2011;80:1271-7 pubmed publisher
    ..generally well tolerated, tyrosine kinase inhibitors have been linked with development of hypertension and proteinuria. We review the literature for incidence and severity of hypertension and proteinuria among several tyrosine ..
  63. Voskarides K, Arsali M, Athanasiou Y, Elia A, Pierides A, Deltas C. Evidence that NPHS2-R229Q predisposes to proteinuria and renal failure in familial hematuria. Pediatr Nephrol. 2012;27:675-9 pubmed publisher
    ..It is now known that TBMN patients develop proteinuria and changes of focal segmental glomerulosclerosis when biopsied...
  64. Stanley J, Andersson I, Poudel R, Rueda Clausen C, Sibley C, Davidge S, et al. Sildenafil citrate rescues fetal growth in the catechol-O-methyl transferase knockout mouse model. Hypertension. 2012;59:1021-8 pubmed publisher
    ..The data presented here demonstrate that Sildenafil can rescue pup growth and improve abnormal umbilical Doppler waveforms, providing support for a potential new therapeutic strategy targeting fetal growth restriction...
  65. Chen G, Zhang L, Jin X, Zhou Y, Niu J, Chen J, et al. Effects of angiogenic factors, antagonists, and podocyte injury on development of proteinuria in preeclampsia. Reprod Sci. 2013;20:579-88 pubmed publisher
    b>Proteinuria is universal to all patients with preeclampsia. We examined the urinary podocytes in women with preeclampsia (n = 14), gestational hypertension (n = 14), and normal pregnancy...
  66. Wang Q, Pang W, Cui Z, Shi J, Liu Y, Liu B, et al. Upregulation of soluble epoxide hydrolase in proximal tubular cells mediated proteinuria-induced renal damage. Am J Physiol Renal Physiol. 2013;304:F168-76 pubmed publisher
    ..The level of sEH in the cortex was positively correlated with proteinuria and negatively with serum albumin level...
  67. Piskinpasa S, Altun B, Akoglu H, Yildirim T, Agbaht K, Yilmaz R, et al. An uninvestigated risk factor for contrast-induced nephropathy in chronic kidney disease: proteinuria. Ren Fail. 2013;35:62-5 pubmed publisher
    ..We aimed to investigate whether proteinuria may act as a risk factor for CIN in patients with chronic kidney disease.
  68. Badri S, Dashti Khavidaki S, Ahmadi F, Mahdavi Mazdeh M, Abbasi M, Khalili H. Effect of add-on pentoxifylline on proteinuria in membranous glomerulonephritis: a 6-month placebo-controlled trial. Clin Drug Investig. 2013;33:215-22 pubmed publisher
    Membranous glomerulonephritis (MGN) may cause proteinuria as the main complication and is a strong risk factor for end-stage renal disease. Current therapeutic regimens provide only partial renoprotection...
  69. Morath C, Wei C, Macher Goeppinger S, Schwenger V, Zeier M, Reiser J. Management of severe recurrent focal segmental glomerulosclerosis through circulating soluble urokinase receptor modification. Am J Ther. 2013;20:226-9 pubmed publisher
    ..and immunoadsorption allowed for lowering of suPAR and reduced podocyte ?(3) integrin activation and proteinuria. The patient is successfully weaned to bimonthly suPAR removal treatments with improved renal parameters...
  70. De Nicola L, Chiodini P, Zoccali C, Borrelli S, Cianciaruso B, Di Iorio B, et al. Prognosis of CKD patients receiving outpatient nephrology care in Italy. Clin J Am Soc Nephrol. 2011;6:2421-8 pubmed publisher
    ..Cumulative incidence of ESRD or death before ESRD were estimated using the competing-risk approach...
  71. Ovunc B, Otto E, Vega Warner V, Saisawat P, Ashraf S, Ramaswami G, et al. Exome sequencing reveals cubilin mutation as a single-gene cause of proteinuria. J Am Soc Nephrol. 2011;22:1815-20 pubmed publisher
    In two siblings of consanguineous parents with intermittent nephrotic-range proteinuria, we identified a homozygous deleterious frameshift mutation in the gene CUBN, which encodes cubulin, using exome capture and massively parallel re-..
  72. Scherzer R, Estrella M, Li Y, Choi A, Deeks S, Grunfeld C, et al. Association of tenofovir exposure with kidney disease risk in HIV infection. AIDS. 2012;26:867-75 pubmed publisher
    ..Despite widespread HAART use, HIV disease remains associated with increased risk of kidney disease. Whether tenofovir use is associated with higher risk of kidney disease is controversial...
  73. Chang J, Pardo V, Sageshima J, Chen L, Tsai H, Reiser J, et al. Podocyte foot process effacement in postreperfusion allograft biopsies correlates with early recurrence of proteinuria in focal segmental glomerulosclerosis. Transplantation. 2012;93:1238-44 pubmed publisher
    ..Thirty to 80% of kidney transplant (KT) recipients with FSGS will experience recurrence characterized by proteinuria and podocyte damage...
  74. Kusinski L, Stanley J, Dilworth M, Hirt C, Andersson I, Renshall L, et al. eNOS knockout mouse as a model of fetal growth restriction with an impaired uterine artery function and placental transport phenotype. Am J Physiol Regul Integr Comp Physiol. 2012;303:R86-93 pubmed publisher
    ..We further postulate that this mouse model demonstrates "uteroplacental hypoxia," providing a new framework for understanding the etiology of FGR in human pregnancy...
  75. Kim S, Song S, Kim I, Jeon Y, Kim B, Kwak I, et al. Urinary cystatin C and tubular proteinuria predict progression of diabetic nephropathy. Diabetes Care. 2013;36:656-61 pubmed publisher
    ..In this prospective observational study, a total of 237 type 2 diabetic patients were followed up for 29 months (13-44 months)...
  76. Iwasa S, Nakajima T, Nagashima K, Honma Y, Kato K, Hamaguchi T, et al. Lack of association of proteinuria and clinical outcome in patients treated with bevacizumab for metastatic colorectal cancer. Anticancer Res. 2013;33:309-16 pubmed
    Although bevacizumab-related hypertension has been reported as a predictive marker of therapy efficacy, an association between proteinuria and efficacy has not been reported.
  77. Rangel Filho A, Lazar J, Moreno C, Geurts A, Jacob H. Rab38 modulates proteinuria in model of hypertension-associated renal disease. J Am Soc Nephrol. 2013;24:283-92 pubmed publisher
    ..BN-Rab38) having less proteinuria than FHH animals...
  78. Rodrigo E, Santos L, Piñera C, Quintanar J, Ruiz J, Fernandez Fresnedo G, et al. Early prediction of new-onset diabetes mellitus by fifth-day fasting plasma glucose, pulse pressure, and proteinuria. Transplant Proc. 2011;43:2208-10 pubmed publisher
    ..The aim of our study was to explore the predictive value of fifth-day fasting plasma glucose (FPG), third-month proteinuria, and pulse pressure (PP) for NODAT development...
  79. Lindsey S, Yamaleyeva L, Brosnihan K, Gallagher P, Chappell M. Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. Hypertension. 2011;58:665-71 pubmed publisher
    ..Despite the lack of an effect on blood pressure, G-1 decreased renal hypertrophy, proteinuria, urinary 8-isoprostane excretion, and tubular 4-hydroxynonenal staining...
  80. Cheng J, Zhang W, Zhang X, Li X, Chen J. Efficacy and safety of paricalcitol therapy for chronic kidney disease: a meta-analysis. Clin J Am Soc Nephrol. 2012;7:391-400 pubmed publisher
    ..newer vitamin D compounds such as paricalcitol can suppress serum intact parathyroid hormone (iPTH) and reduce proteinuria in patients with CKD...
  81. Kumai Y, Kamouchi M, Hata J, Ago T, Kitayama J, Nakane H, et al. Proteinuria and clinical outcomes after ischemic stroke. Neurology. 2012;78:1909-15 pubmed publisher
    ..The aim of the present study was to elucidate how CKD and its components, proteinuria and low estimated glomerular filtration rate (eGFR), affect the clinical outcomes after ischemic stroke.
  82. Sivaskandarajah G, Jeansson M, Maezawa Y, Eremina V, Baelde H, Quaggin S. Vegfa protects the glomerular microvasculature in diabetes. Diabetes. 2012;61:2958-66 pubmed publisher
    ..We then assessed the extent of glomerular dysfunction by measuring proteinuria, glomerular pathology, and glomerular cell apoptosis...
  83. de Goeij M, Liem M, de Jager D, Voormolen N, Sijpkens Y, Rotmans J, et al. Proteinuria as a risk marker for the progression of chronic kidney disease in patients on predialysis care and the role of angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker treatment. Nephron Clin Pract. 2012;121:c73-82 pubmed publisher
    b>Proteinuria is a risk marker for progression of chronic kidney disease (CKD) and treatment with an angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker (ACEi/ARB) is beneficial in these patients...
  84. Agrawal V, Prasad N, Jain M, Pandey R. Reduced podocin expression in minimal change disease and focal segmental glomerulosclerosis is related to the level of proteinuria. Clin Exp Nephrol. 2013;17:811-8 pubmed publisher
    ..However, their role in primary nephrotic syndrome is not clear. This study investigated the expression of nephrin, podocin and synaptopodin in primary nephrotic syndrome...
  85. Tonelli M, Klarenbach S, Lloyd A, James M, Bello A, Manns B, et al. Higher estimated glomerular filtration rates may be associated with increased risk of adverse outcomes, especially with concomitant proteinuria. Kidney Int. 2011;80:1306-14 pubmed publisher
    ..73 m(2) could also be at elevated risk of adverse outcomes. Further, we tested whether concomitant proteinuria further increases the risk of outcomes among individuals with an eGFR equal to or above 90 ml/min per 1...
  86. Iseki K, Asahi K, Moriyama T, Yamagata K, Tsuruya K, Yoshida H, et al. Risk factor profiles based on estimated glomerular filtration rate and dipstick proteinuria among participants of the Specific Health Check and Guidance System in Japan 2008. Clin Exp Nephrol. 2012;16:244-9 pubmed publisher
    Estimated glomerular filtration rate (eGFR) and albuminuria (proteinuria) are both important determinants of the risk of cardiovascular disease (CVD), end-stage renal disease (ESRD), and mortality...
  87. Chaumont A, Nickmilder M, Dumont X, Lundh T, Skerfving S, Bernard A. Associations between proteins and heavy metals in urine at low environmental exposures: evidence of reverse causality. Toxicol Lett. 2012;210:345-52 pubmed publisher
  88. Zhou W, Hildebrandt F. Inducible podocyte injury and proteinuria in transgenic zebrafish. J Am Soc Nephrol. 2012;23:1039-47 pubmed publisher
    ..zebrafish expressing green fluorescent protein (GFP)-tagged vitamin D-binding protein (VDBP) as a tracer for proteinuria. In the VDBP-GFP and pod::NTR-mCherry double-transgenic fish, induction of podocyte damage led to whole-body ..
  89. Yano Y, Sato Y, Fujimoto S, Konta T, Iseki K, Moriyama T, et al. Association of high pulse pressure with proteinuria in subjects with diabetes, prediabetes, or normal glucose tolerance in a large Japanese general population sample. Diabetes Care. 2012;35:1310-5 pubmed publisher
    To examine whether there is a difference in the association between high pulse pressure and proteinuria, independent of other blood pressure (BP) indices, such as systolic or diastolic BP, among subjects with diabetes, prediabetes, or ..
  90. Ren P, Han F, Chen L, Xu Y, Wang Y, Chen J. The combination of mycophenolate mofetil with corticosteroids induces remission of Henoch-Schönlein purpura nephritis. Am J Nephrol. 2012;36:271-7 pubmed publisher
    ..Our aim was to compare the effects of oral mycophenolate mofetil (MMF) with low-dose prednisone and the full-dose corticosteroids (CS; prednisone) for the induction therapy of HSPN with large proteinuria.
  91. Akerstrom M, Sallsten G, Lundh T, Barregard L. Associations between urinary excretion of cadmium and proteins in a nonsmoking population: renal toxicity or normal physiology?. Environ Health Perspect. 2013;121:187-91 pubmed publisher
    ..Associations between cadmium (Cd) and kidney function have been reported even at low levels of exposure in the general population. Recently, the causality of these associations has been questioned...
  92. Sasongko T, Nagalla S, Ballas S. Angiotensin-converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease. Cochrane Database Syst Rev. 2013;:CD009191 pubmed publisher
    ..Microalbuminuria and proteinuria are noted to be a strong predictor of subsequent renal failure...