Summary: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Top Publications

  1. Udpa N, Ronen R, Zhou D, Liang J, Stobdan T, Appenzeller O, et al. Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes. Genome Biol. 2014;15:R36 pubmed publisher
    ..This region contains eight protein-coding genes and spans 135 SNPs. To elucidate its potential role in hypoxia tolerance, we experimentally tested whether individual genes from the region affect hypoxia tolerance in ..
  2. Robb K, Cotechini T, Allaire C, Sperou A, Graham C. Inflammation-induced fetal growth restriction in rats is associated with increased placental HIF-1? accumulation. PLoS ONE. 2017;12:e0175805 pubmed publisher
    b>Hypoxia-inducible factor 1-alpha (HIF-1?) is the oxygen-sensitive subunit of the transcription factor HIF-1, and its expression is increased in placentas from pregnancies complicated by pre-eclampsia (PE)...
  3. Wilkins M, Ghofrani H, Weissmann N, Aldashev A, Zhao L. Pathophysiology and treatment of high-altitude pulmonary vascular disease. Circulation. 2015;131:582-90 pubmed publisher
  4. Wang X, Ma Q, Ding A, Zeng B, Wang F. [Effects of intermittent hypoxia on long-term potentiation in hippocampal dentate gyrus of rat]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2001;17:18-20 pubmed
    To investigate the effects of intermittent hypoxia on the hippocampal synaptic plasticity in rat. The evoked potentials were recorded extracellularly, then the LTP were induced by tetanic stimulation in rat hippocampal dentate gyrus...
  5. Thorpe R, Hubbell M, Silpanisong J, Williams J, Pearce W. Chronic hypoxia attenuates the vasodilator efficacy of protein kinase G in fetal and adult ovine cerebral arteries. Am J Physiol Heart Circ Physiol. 2017;313:H207-H219 pubmed publisher
    Long-term hypoxia (LTH) attenuates nitric oxide-induced vasorelaxation in ovine middle cerebral arteries...
  6. Li Y, Run L, Shi T, Zhang Y. CTRP9 regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and migration via TGF-?1/ERK1/2 signaling pathway. Biochem Biophys Res Commun. 2017;490:1319-1325 pubmed publisher
    b>Hypoxia is an important risk factor for pulmonary arterial remodeling in pulmonary arterial hypertension (PAH)...
  7. Serebrovska T, Portnychenko A, Drevytska T, Portnichenko V, Xi L, Egorov E, et al. Intermittent hypoxia training in prediabetes patients: Beneficial effects on glucose homeostasis, hypoxia tolerance and gene expression. Exp Biol Med (Maywood). 2017;242:1542-1552 pubmed publisher
    The present study aimed at examining beneficial effects of intermittent hypoxia training (IHT) under prediabetic conditions...
  8. Dean E. Effect of body position on pulmonary function. Phys Ther. 1985;65:613-8 pubmed
    ..Such work may help to refine pulmonary physical therapy procedures and to identify the role of judicious positioning in a therapeutic exercise regimen. ..
  9. Donner H. Is There a Doctor Onboard? Medical Emergencies at 40,000 Feet. Emerg Med Clin North Am. 2017;35:443-463 pubmed publisher
    ..From resource management to equipment, this article sheds light on the unique conditions, challenges, and constraints of the flight environment. ..

More Information


  1. Walz J. Point: Should an anesthesiologist be the specialist of choice in managing the difficult airway in the ICU? Yes. Chest. 2012;142:1372-1374 pubmed publisher
  2. Peek G, Moore H, Moore N, Sosnowski A, Firmin R. Extracorporeal membrane oxygenation for adult respiratory failure. Chest. 1997;112:759-64 pubmed
    ..46 (95% confidence interval, 0.22 to 0.97, p=0.036). Survival with ECMO is 66% for adults with severe respiratory failure. ECMO should be considered in patients who remain hypoxic despite maximal positive pressure ventilation. ..
  3. Crossley D, Altimiras J, Wang T. Hypoxia elicits an increase in pulmonary vasculature resistance in anaesthetised turtles (Trachemys scripta). J Exp Biol. 1998;201:3367-75 pubmed
    ..During severe hypoxia (1...
  4. Hood K, Mair K, Harvey A, Montezano A, Touyz R, MacLean M. Serotonin Signaling Through the 5-HT1B Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension. Arterioscler Thromb Vasc Biol. 2017;37:1361-1370 pubmed publisher
    ..Our results suggest that 5-HT1B receptor-dependent cellular Src-related kinase-Nox1-pathways contribute to vascular remodeling in PAH. ..
  5. Shirane M, Harrison R. The effects of hypoxia on sensory cells of the cochlea in chinchilla. Scanning Microsc. 1987;1:1175-83 pubmed
    The effects of hypoxia on the sensory epithelium of the cochlea were investigated in the chinchilla. Systemic hypoxia was produced by increasing the dead space of the respiratory tidal volume...
  6. Bunge J, Wiersema U, Moelker A, van Bommel J, Tjwa E. Refractory hypoxemia in a 23-year-old patient with Budd-Chiari syndrome. Chest. 2014;146:e149-e152 pubmed publisher
    ..Within the same procedure, the hepatic outflow obstruction was successfully treated by stenting a severe stenosis of the suprahepatic inferior vena cava caused by calcified thrombus. ..
  7. Van de Louw A, Haouzi P. Oxygen deficit and H2S in hemorrhagic shock in rats. Crit Care. 2012;16:R178 pubmed publisher
    ..Hydroxocobalamin, while effective against H2S in vitro, did not affect the hemodynamic profile or outcome in our model. ..
  8. Millet G, Faiss R, Pialoux V. Last word on Point: Counterpoint: Hypobaric hypoxia induces different responses from normobaric hypoxia. J Appl Physiol (1985). 2012;112:1795 pubmed publisher
  9. Restin T, Kajdi M, Schl├Ąpfer M, Roth Z graggen B, Booy C, Dumrese C, et al. Sevoflurane protects rat brain endothelial barrier structure and function after hypoxia-reoxygenation injury. PLoS ONE. 2017;12:e0184973 pubmed publisher
    ..Volatile anesthetics have been shown to be protective in ischemia-reperfusion injury scenarios. Their impact on brain endothelial cells after hypoxia-reoxygenation (H/R) has not yet been studied in detail.
  10. Haw A, Hofmeyr M, Fuller A, Buss P, Miller M, Fleming G, et al. Butorphanol with oxygen insufflation corrects etorphine-induced hypoxaemia in chemically immobilized white rhinoceros (Ceratotherium simum). BMC Vet Res. 2014;10:253 pubmed publisher
    ..The efficacy of this intervention in reducing respiratory depression in field-captured animals remains to be determined. ..
  11. Holden J, Stone C, Clark C, Brown W, Nickles R, Stanley C, et al. Enhanced cardiac metabolism of plasma glucose in high-altitude natives: adaptation against chronic hypoxia. J Appl Physiol (1985). 1995;79:222-8 pubmed
    ..To assess the role of substrate preference in adaptations to chronic hypoxia, positron emission tomographic measurements of heart regional glucose uptake rates after an overnight fast were ..
  12. Eltzschig H, Carmeliet P. Hypoxia and inflammation. N Engl J Med. 2011;364:656-65 pubmed publisher
  13. Baertschi A, Hausmaninger C, Walsh R, Mentzer R, Wyatt D, Pence R. Hypoxia-induced release of atrial natriuretic factor (ANF) from the isolated rat and rabbit heart. Biochem Biophys Res Commun. 1986;140:427-33 pubmed
    The effect of hypoxia on the release of atrial natriuretic factor (ANF) was studied in isolated, constant-flow perfused hearts of rats and rabbits. Effluent samples were frozen pending extraction and radioimmunoassay of ANF...
  14. Zhang K, Jiang D. RhoA inhibits the hypoxia-induced apoptosis and mitochondrial dysfunction in chondrocytes via positively regulating the CREB phosphorylation. Biosci Rep. 2017;37: pubmed publisher
    ..the growth plate or the intervertebral disc are sensitive to environmental stresses, such as inflammation and hypoxia. However, little is known about the molecular signalling pathways underlining the hypoxia-induced mitochondrial ..
  15. Yang C, Hong C, Zhuang Z. Hypoxia and glioblastoma therapy. Aging (Albany NY). 2015;7:523-4 pubmed
  16. Voskuil M, Schlesinger L. Toward Resolving the Paradox of the Critical Role of the DosR Regulon in Mycobacterium tuberculosis Persistence and Active Disease. Am J Respir Crit Care Med. 2015;191:1103-5 pubmed publisher
  17. Granchi C, Funaioli T, Erler J, Giaccia A, Macchia M, Minutolo F. Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours. ChemMedChem. 2009;4:1590-4 pubmed publisher
  18. Park J, Lee Y. Hypoxia induced phosphorylation of estrogen receptor at serine 118 in the absence of ligand. J Steroid Biochem Mol Biol. 2017;174:146-152 pubmed publisher
    The estrogen receptor (ER) plays an important role in breast cancer development and progression. Hypoxia modulates the level of ER? expression and induces ligand-independent transcriptional activation of ER?, which is closely related ..
  19. Nelson L, Civetta J, Hudson Civetta J. Titrating positive end-expiratory pressure therapy in patients with early, moderate arterial hypoxemia. Crit Care Med. 1987;15:14-9 pubmed
    ..1/20), ICU mortality (22% vs. 20%), or overall mortality (33% vs. 25%). The number of blood gas analyses and cardiac output measurements, and the total hospital charges were also similar in both groups.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  20. Li P, Liu Y, Burns N, Zhao K, Song R. SIRT1 is required for mitochondrial biogenesis reprogramming in hypoxic human pulmonary arteriolar smooth muscle cells. Int J Mol Med. 2017;39:1127-1136 pubmed publisher
    ..mitochondrial biogenesis regulatory program in pulmonary arteriolar smooth muscle cells (PASMCs) during hypoxia/reoxygenation (H/R)...
  21. Marotta S, Sithichoke N, Garcy A, Yu M. Adrenocortical responses of rats to acute hypoxic and hypercapnic stresses after treatment with aminergic agents. Neuroendocrinology. 1976;20:182-92 pubmed
    ..influences on the regulation of the hypothalamo-hypophyseal-adrenocortical (HHA) system during acute stresses (hypoxia and hypercapnia) were investigated in male rats...
  22. Plotnikov E, Pavlenko T, Pevzner I, Zorova L, Manskikh V, Silachev D, et al. The role of oxidative stress in acute renal injury of newborn rats exposed to hypoxia and endotoxin. FEBS J. 2017;284:3069-3078 pubmed publisher
    ..In this study, we explored the development of acute kidney injury (AKI) in neonatal rats during hypoxia or administration of endotoxin...
  23. Arieli R. Can the rat detect hypoxia in inspired air?. Respir Physiol. 1990;79:243-53 pubmed
    Rats reacted in immediate escape response to encounters with severe hypoxia. This led to a test of the hypothesis that mammals which live in closed spaces (burrows) should have a hypoxic alarm mechanism...
  24. Zhang W, Zhou X, Yao Q, Liu Y, Zhang H, Dong Z. HIF-1-mediated production of exosomes during hypoxia is protective in renal tubular cells. Am J Physiol Renal Physiol. 2017;313:F906-F913 pubmed publisher
    ..The production and function of exosomes in kidney tissues and cells remain largely unclear. Hypoxia is a common pathophysiological condition in kidneys...
  25. He L, Zhang X, Huang Y, Yang H, Wang Y, Zhang Z. The characterization of RHEB gene and its responses to hypoxia and thermal stresses in the small abalone Haliotis diversicolor. Comp Biochem Physiol B Biochem Mol Biol. 2017;210:48-54 pubmed publisher
    ..the RHEB gene in the small abalone Haliotis diversicolor, and identify the responses of RHEB gene to stresses of hypoxia or/and thermal. The objectives were to: 1) clone the full-length cDNA RHEB gene in the H...
  26. Kirkman M, Citerio G, Smith M. The intensive care management of acute ischemic stroke: an overview. Intensive Care Med. 2014;40:640-53 pubmed
    ..Encouragement of large-scale recruitment of patients with AIS into clinical trials should aid the development of robust evidence for the benefit of different interventions in the ICU on outcome. ..
  27. Jawhari S, Bessette B, Hombourger S, Durand K, Lacroix A, Labrousse F, et al. Autophagy and TrkC/NT-3 signaling joined forces boost the hypoxic glioblastoma cell survival. Carcinogenesis. 2017;38:592-603 pubmed publisher
    ..multiform (GBM), the most common and aggressive primary brain tumor, is characterized by a high degree of hypoxia and resistance to therapy because of its adaptation capacities, including autophagy and growth factors signaling...
  28. Galie N, Hoeper M, Humbert M, Torbicki A, Vachiery J, Barbera J, et al. Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the Int. Eur Heart J. 2009;30:2493-537 pubmed publisher
  29. Epstein F, Agmon Y, Brezis M. Physiology of renal hypoxia. Ann N Y Acad Sci. 1994;718:72-81; discussion 81-2 pubmed
  30. Rossdale P. Modern concepts of neonatal disease in foals. Equine Vet J. 1972;4:117-28 pubmed
  31. Chance B, Leigh J, Clark B, Maris J, Kent J, Nioka S, et al. Control of oxidative metabolism and oxygen delivery in human skeletal muscle: a steady-state analysis of the work/energy cost transfer function. Proc Natl Acad Sci U S A. 1985;82:8384-8 pubmed
  32. Lewis D, Blatchley M, Park K, Gerecht S. O2-controllable hydrogels for studying cellular responses to hypoxic gradients in three dimensions in vitro and in vivo. Nat Protoc. 2017;12:1620-1638 pubmed publisher
    ..This platform has been applied to study vascular morphogenesis in response to hypoxia and to understand how oxygen gradients mediate cancer cell behavior...
  33. Safar P, Xiao F, Radovsky A, Tanigawa K, Ebmeyer U, Bircher N, et al. Improved cerebral resuscitation from cardiac arrest in dogs with mild hypothermia plus blood flow promotion. Stroke. 1996;27:105-13 pubmed
    ..We hypothesized that a multifaceted combination treatment would achieve complete cerebral recovery...
  34. Karigane D, Takubo K. Metabolic regulation of hematopoietic and leukemic stem/progenitor cells under homeostatic and stress conditions. Int J Hematol. 2017;106:18-26 pubmed publisher
  35. Del Rio R. The carotid body and its relevance in pathophysiology. Exp Physiol. 2015;100:121-3 pubmed
  36. Patzig M, Laub C, Janssen H, Ertl L, Fesl G. Pseudo-subarachnoid haemorrhage due to chronic hypoxaemia: case report and review of the literature. BMC Neurol. 2014;14:219 pubmed publisher
    ..A diagnosis of pseudo-SAH was made. The patient's symptoms were likely due to a secondary headache attributed to hypoxia and/or hypercapnia. Therapy was symptomatic...
  37. Chaddha U, Puscas I, Prosper A, Ganesh S, Yaghmour B. A 63-Year-Old Woman With Neurofibromatosis Type 1 and Pulmonary Hypertension With Worsening Hypoxemia. Chest. 2017;152:e89-e93 pubmed publisher
    ..She denied tobacco, alcohol, and illicit or anorectic drug use. She had previously worked as a waitress. Her mother and her brother had NF-1 but no PH or lung disease. ..
  38. Feng J, Chen B, Cui L. Carotid body-mediated changes of sympathetic nerve and their relationships with hypertension. Chin Med J (Engl). 2008;121:1732-5 pubmed
  39. Kaihami G, Breda L, de Almeida J, de Oliveira Pereira T, Nicastro G, Boechat A, et al. The Atypical Response Regulator AtvR Is a New Player in Pseudomonas aeruginosa Response to Hypoxia and Virulence. Infect Immun. 2017;85: pubmed publisher
    ..Further, several genes involved in hypoxia/anoxia adaptation were upregulated upon atvR overexpression, as seen by high-throughput transcriptome ..
  40. Powell F. Adaptation to chronic hypoxia involves immune cell invasion and increased expression of inflammatory cytokines in rat carotid body. Am J Physiol Lung Cell Mol Physiol. 2009;296:L156-7 pubmed publisher
  41. Bardwell W, Berry C, Ancoli Israel S, Dimsdale J. Psychological correlates of sleep apnea. J Psychosom Res. 1999;47:583-96 pubmed
    ..Although various psychological measures correlate with sleep variables in sleep apnea subjects, many are explained by controlling age, body mass, and hypertension. Anger and vigor, however, remain associated with sleep variables. ..
  42. Du L, Zhou A, Patel A, Rao M, Anderson K, Roy S. Unique patterns of organization and migration of FGF-expressing cells during Drosophila morphogenesis. Dev Biol. 2017;427:35-48 pubmed publisher
    ..spatiotemporal expression of the reporter in various embryonic stages, larval or adult tissues and in metabolic hypoxia, confirmed its target specificity and versatility...
  43. Bojko T, Notterman D, Greenwald B, De Bruin W, Magid M, Godwin T. Acute hypoxemic respiratory failure in children following bone marrow transplantation: an outcome and pathologic study. Crit Care Med. 1995;23:755-9 pubmed
  44. Knighton D, Halliday B, Hunt T. Oxygen as an antibiotic. The effect of inspired oxygen on infection. Arch Surg. 1984;119:199-204 pubmed
    ..fraction of inspired oxygen [Flo2]) significantly decreased the size and number of necrotic lesions, whereas hypoxia increased both...
  45. Raoof S, Baumann M. Ventilator-associated events: the new definition. Am J Crit Care. 2014;23:7-9 pubmed publisher
  46. Sawyer A, Wise L, Ghosh S, Bhatia J, Stansfield B. Comparison of transfusion thresholds during neonatal extracorporeal membrane oxygenation. Transfusion. 2017;57:2115-2120 pubmed publisher
    ..A lower Hct threshold of 35% is associated with a reduction in RBC transfusion volume and does not appear to alter complication rates or patient outcomes for neonates receiving ECMO support for respiratory failure. ..
  47. Bielecka Wajdman A, Lesiak M, Ludyga T, Sieron A, Obuchowicz E. Reversing glioma malignancy: a new look at the role of antidepressant drugs as adjuvant therapy for glioblastoma multiforme. Cancer Chemother Pharmacol. 2017;79:1249-1256 pubmed publisher
    ..These drugs were examined in several models of hypoxia (1% oxygen, 2...
  48. Benet T, Picot V, Awasthi S, Pandey N, Bavdekar A, Kawade A, et al. Severity of Pneumonia in Under 5-Year-Old Children from Developing Countries: A Multicenter, Prospective, Observational Study. Am J Trop Med Hyg. 2017;97:68-76 pubmed publisher
    ..hMPV and RSV in respiratory samples were linked with hypoxemia, and S. pneumoniae in blood was associated with increased risk of death among hospitalized children with pneumonia in developing countries. ..
  49. Duffin J. The chemoreflex control of breathing and its measurement. Can J Anaesth. 1990;37:933-42 pubmed
    ..The peripheral chemoreflex, the ventilatory response to carbon dioxide and hypoxia mediated by the peripheral chemoreceptors, is broken into two relations...
  50. Saad A, Dietz A, Herrmann S, Hickson L, Glockner J, McKusick M, et al. Autologous Mesenchymal Stem Cells Increase Cortical Perfusion in Renovascular Disease. J Am Soc Nephrol. 2017;28:2777-2785 pubmed publisher
    ..5 ml/min, P=0.01); contralateral kidney RBF increased (212.7-271.8 ml/min, P=0.01); and STK renal hypoxia (percentage of the whole kidney with R2*>30/s) decreased (12.1% [interquartile range, 3.3%-17.8%] to 6...
  51. Sharma B, Ho L, Ford G, Chen H, Goldstone A, Woo Y, et al. Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts. Dev Cell. 2017;42:655-666.e3 pubmed publisher
    ..Our data demonstrate that by diversifying their responsivity to growth cues, distinct coronary progenitor pools are able to compensate for each other during coronary development, thereby providing robustness to organ development. ..
  52. Sivak E, Richmond B, O Donavan P, Borkowski G. Value of extravascular lung water measurement vs portable chest x-ray in the management of pulmonary edema. Crit Care Med. 1983;11:498-501 pubmed
    ..No correlation was found between venous admixture Qsp/Qt, pulmonary capillary wedge pressure (WP) or ETVL values. Measurement of ETVL may aid in the care of critically ill patients with suspected pulmonary edema. ..
  53. Murata K, Fang C, Terao C, Giannopoulou E, Lee Y, Lee M, et al. Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis. Immunity. 2017;47:66-79.e5 pubmed publisher
    b>Hypoxia augments inflammatory responses and osteoclastogenesis by incompletely understood mechanisms. We identified COMMD1 as a cell-intrinsic negative regulator of osteoclastogenesis that is suppressed by hypoxia...