Summary: An abnormal increase in the amount of oxygen in the tissues and organs.

Top Publications

  1. Queiroga F, Nunes M, Meda E, Chiappa G, Machado M, Nery L, et al. Exercise tolerance with helium-hyperoxia versus hyperoxia in hypoxaemic patients with COPD. Eur Respir J. 2013;42:362-70 pubmed publisher
    The purpose of this study was to investigate whether helium-hyperoxia (HeHOx) would allow greater tolerance to maximal and submaximal exercise compared to hyperoxia (HOx) on isolation in hypoxaemic chronic obstructive pulmonary disease (..
  2. Ma L, Li N, Liu X, Shaw L, Li Calzi S, Grant M, et al. Arginyl-glutamine dipeptide or docosahexaenoic acid attenuate hyperoxia-induced lung injury in neonatal mice. Nutrition. 2012;28:1186-91 pubmed publisher
    ..Arg-Gln) or DHA, a long-chain ?-3 fatty acid with anti-inflammatory properties, to exert benefits on hyperoxia-induced lung injury has not to our knowledge been investigated...
  3. Blockley N, Driver I, Fisher J, Francis S, Gowland P. Measuring venous blood volume changes during activation using hyperoxia. Neuroimage. 2012;59:3266-74 pubmed publisher
    This study describes a novel method for measuring relative changes in venous cerebral blood volume (CBVv) using hyperoxia as a contrast agent...
  4. Blasiole B, Bayr H, Vagni V, Janesko Feldman K, Cheikhi A, Wisniewski S, et al. Effect of hyperoxia on resuscitation of experimental combined traumatic brain injury and hemorrhagic shock in mice. Anesthesiology. 2013;118:649-63 pubmed publisher
    ..Hyperoxic resuscitation is controversial. The authors proposed that hyperoxia would improve hemodynamics and neuronal survival by augmenting oxygen delivery despite increased oxidative ..
  5. Li L, Yang C, Huang C, Liu Y, Kao K, Lin H. Low-molecular-weight heparin reduces hyperoxia-augmented ventilator-induced lung injury via serine/threonine kinase-protein kinase B. Respir Res. 2011;12:90 pubmed publisher
    High-tidal-volume mechanical ventilation and hyperoxia used in patients with acute lung injury (ALI) can induce the release of cytokines, including high-mobility group box-1 (HMGB1), oxygen radicals, neutrophil infiltration, and the ..
  6. Jia Y, Li P, Dziennis S, Wang R. Responses of peripheral blood flow to acute hypoxia and hyperoxia as measured by optical microangiography. PLoS ONE. 2011;6:e26802 pubmed publisher
    ..There is a debate as to how peripheral blood flow (PBF) is affected and modulated during hypoxia and hyperoxia; however in vivo evaluating of functional PBF under oxygen-related physiological perturbation remains ..
  7. Fukumoto J, Fukumoto I, Parthasarathy P, Cox R, Huynh B, Ramanathan G, et al. NLRP3 deletion protects from hyperoxia-induced acute lung injury. Am J Physiol Cell Physiol. 2013;305:C182-9 pubmed publisher
    ..a therapy for acute lung injury (ALI), could unexpectedly lead to reactive oxygen species (ROS) production and hyperoxia-induced acute lung injury (HALI)...
  8. Buczynski B, Maduekwe E, O Reilly M. The role of hyperoxia in the pathogenesis of experimental BPD. Semin Perinatol. 2013;37:69-78 pubmed publisher
  9. Bendix I, Weichelt U, Strasser K, Serdar M, Endesfelder S, von Haefen C, et al. Hyperoxia changes the balance of the thioredoxin/peroxiredoxin system in the neonatal rat brain. Brain Res. 2012;1484:68-75 pubmed publisher
    ..Additionally, hyperoxia reduced the level of DJ-1, a hydroperoxide-responsive protein in the developing rat brain...

Scientific Experts

More Information


  1. Ramani M, van Groen T, Kadish I, Bulger A, Ambalavanan N. Neurodevelopmental impairment following neonatal hyperoxia in the mouse. Neurobiol Dis. 2013;50:69-75 pubmed publisher
    ..objectives were to develop and characterize a mouse model to determine long-term effects of chronic hypoxia or hyperoxia exposure on neurodevelopment...
  2. de Visser Y, Walther F, Laghmani E, Steendijk P, Middeldorp M, van der Laarse A, et al. Phosphodiesterase 4 inhibition attenuates persistent heart and lung injury by neonatal hyperoxia in rats. Am J Physiol Lung Cell Mol Physiol. 2012;302:L56-67 pubmed publisher
    ..therapeutic value on pulmonary hypertension (PH) and right ventricular hypertrophy (RVH) in neonatal rats with hyperoxia-induced lung injury, a valuable model for premature infants with severe BPD...
  3. Clough A, Audi S, Haworth S, Roerig D. Differential lung uptake of 99mTc-hexamethylpropyleneamine oxime and 99mTc-duramycin in the chronic hyperoxia rat model. J Nucl Med. 2012;53:1984-91 pubmed publisher
    ..Thus, we investigated changes in lung uptake of these agents in rats exposed to hyperoxia for prolonged periods, a common model of acute lung injury.
  4. Tea M, Michael M, Brereton H, Williams K. Stability of small non-coding RNA reference gene expression in the rat retina during exposure to cyclic hyperoxia. Mol Vis. 2013;19:501-8 pubmed
  5. Mittal R, Hammel M, Schwarz J, Heschl K, Bretschneider N, Flemmer A, et al. SFTA2--a novel secretory peptide highly expressed in the lung--is modulated by lipopolysaccharide but not hyperoxia. PLoS ONE. 2012;7:e40011 pubmed publisher
    ..b>Hyperoxia, however, did not alter SFTA2 mRNA levels...
  6. Makena P, Gorantla V, Ghosh M, Bezawada L, Balazs L, Luellen C, et al. Lung injury caused by high tidal volume mechanical ventilation and hyperoxia is dependent on oxidant-mediated c-Jun NH2-terminal kinase activation. J Appl Physiol (1985). 2011;111:1467-76 pubmed publisher
    Both prolonged exposure to hyperoxia and large tidal volume mechanical ventilation can each independently cause lung injury. However, the combined impact of these insults is poorly understood...
  7. Lee H, Kim B, Choi E, Choi C, Kim E, Kim H, et al. Effects of postnatal dexamethasone or hydrocortisone in a rat model of antenatal lipopolysaccharide and neonatal hyperoxia exposure. J Korean Med Sci. 2012;27:395-401 pubmed publisher
    ..A rat model of BPD was induced by administering intra-amniotic lipopolysaccharide (LPS) and postnatal hyperoxia. The rats were treated with a 6-day (D1-D6) tapering course of DXM (starting dose 0...
  8. Knaapi J, Lukkarinen H, Kiviranta R, Vuorio E, Kääpä P. Cathepsin K deficiency aggravates lung injury in hyperoxia-exposed newborn mice. Exp Lung Res. 2011;37:408-18 pubmed publisher
    ..b>Hyperoxia caused fatal respiratory distress in both groups of mice...
  9. Dong J, Carey W, Abel S, Collura C, Jiang G, Tomaszek S, et al. MicroRNA-mRNA interactions in a murine model of hyperoxia-induced bronchopulmonary dysplasia. BMC Genomics. 2012;13:204 pubmed publisher
    ..There is increasing evidence that microRNAs (miRNAs) regulate translation of messenger RNAs (mRNAs) during lung organogenesis. The potential role of miRNAs in the pathogenesis of BPD is unclear...
  10. Alapati D, Rong M, Chen S, Hehre D, Rodriguez M, Lipson K, et al. Connective tissue growth factor antibody therapy attenuates hyperoxia-induced lung injury in neonatal rats. Am J Respir Cell Mol Biol. 2011;45:1169-77 pubmed publisher
    ..Previous studies have demonstrated that hyperoxia exposure up-regulates CTGF expression in neonatal rat lungs...
  11. Mousavi S, Abdollahi M, Ahmadi A, Najafi A, Pazouki M, Hadjibabaie M, et al. The dilemma of hyperoxia following positive pressure mechanical ventilation: role of iron and the benefit of iron chelation with deferasirox. Eur Rev Med Pharmacol Sci. 2011;15:1141-8 pubmed
    Increased oxidative stress in patients under treatment with high concentrations of oxygen (hyperoxia) is considered to be one of the major mechanisms of lung injury, which is thought among different mediators, transition metal ion, iron, ..
  12. Tanaka A, Jin Y, Lee S, Zhang M, Kim H, Stolz D, et al. Hyperoxia-induced LC3B interacts with the Fas apoptotic pathway in epithelial cell death. Am J Respir Cell Mol Biol. 2012;46:507-14 pubmed publisher
    Epithelial cell death plays a critical role in hyperoxia-induced lung injury. We investigated the involvement of the autophagic marker microtubule-associated protein-1 light chain-3B (LC3B) in epithelial cell apoptosis after hyperoxia...
  13. Ali N, Jafri A, Sopi R, Prakash Y, Martin R, Zaidi S. Role of arginase in impairing relaxation of lung parenchyma of hyperoxia-exposed neonatal rats. Neonatology. 2012;101:106-15 pubmed publisher
    Prolonged exposure of immature lungs to hyperoxia contributes to neonatal lung injury and airway hyperreactivity...
  14. Jia Y, Li P, Wang R. Optical microangiography provides an ability to monitor responses of cerebral microcirculation to hypoxia and hyperoxia in mice. J Biomed Opt. 2011;16:096019 pubmed publisher
    ..understanding of cerebral microhemodynamics under various physiological challenges, such as hypoxia and hyperoxia. However, existing techniques often involve the use of invasive procedures or exogenous contrast agents, which ..
  15. Krnic M, Modun D, Budimir D, Gunjaca G, Jajić I, Vukovic J, et al. Comparison of acute effects of red wine, beer and vodka against hyperoxia-induced oxidative stress and increase in arterial stiffness in healthy humans. Atherosclerosis. 2011;218:530-5 pubmed publisher
    ..We determined and compared acute effects of different alcoholic beverages on oxygen-induced increase in oxidative stress plasma marker and arterial stiffness in healthy humans...
  16. Sun H, Choo Wing R, Sureshbabu A, Fan J, Leng L, Yu S, et al. A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung. PLoS ONE. 2013;8:e60560 pubmed publisher
    The role and mechanism of action of MIF in hyperoxia-induced acute lung injury (HALI) in the newborn lung are not known. We hypothesized that MIF is a critical regulatory molecule in HALI in the developing lung.
  17. Jin X, Liu J, LIU K, Rosenberg G, Yang Y, Liu W. Normobaric hyperoxia combined with minocycline provides greater neuroprotection than either alone in transient focal cerebral ischemia. Exp Neurol. 2013;240:9-16 pubmed publisher
    Normobaric hyperoxia (NBO), which maintains penumbral oxygenation, reduces brain injury during cerebral ischemia, and minocycline, a tetracycline derivative, reduces reperfusion injury, including inflammation, apoptosis and matrix ..
  18. Hummler S, Rong M, Chen S, Hehre D, Alapati D, Wu S. Targeting glycogen synthase kinase-3? to prevent hyperoxia-induced lung injury in neonatal rats. Am J Respir Cell Mol Biol. 2013;48:578-88 pubmed publisher
    ..We tested the hypothesis that inhibition of GSK-3? is beneficial in preventing hyperoxia-induced neonatal lung injury, an experimental model of BPD...
  19. Li Y, Cai M, Sun Q, Liu Z, Cardounel A, Swartz H, et al. Hyperoxia and transforming growth factor ?1 signaling in the post-ischemic mouse heart. Life Sci. 2013;92:547-54 pubmed publisher
    ..The current study tests the hypothesis that hyperoxia and nitric oxide (NO) regulate TGF-?1 signaling in the post-ischemic myocardium.
  20. Oussaidene K, Prieur F, Bougault V, Borel B, Matran R, Mucci P. Cerebral oxygenation during hyperoxia-induced increase in exercise tolerance for untrained men. Eur J Appl Physiol. 2013;113:2047-56 pubmed publisher
    ..kg(-1)) performed two randomized exhaustive ramp exercises on a cycle ergometer (1 W/3 s) under normoxia and hyperoxia (FIO2 = 0.3)...
  21. Liu W, Liu K, Tao H, Chen C, Zhang J, Sun X. Hyperoxia preconditioning: the next frontier in neurology?. Neurol Res. 2012;34:415-21 pubmed publisher
    ..b>Hyperoxia preconditioning with normobaric or hyperbaric oxygen has been found to be protective in some diseases in ..
  22. Waisman D, Brod V, Rahat M, Amit Cohen B, Lahat N, Rimar D, et al. Dose-related effects of hyperoxia on the lung inflammatory response in septic rats. Shock. 2012;37:95-102 pubmed publisher
    We evaluated the effects of hyperoxia on pulmonary inflammatory changes in sepsis induced by cecal ligation and puncture (CLP) in rats...
  23. Liu C, Weaver J, Liu K. Rapid conditioning with oxygen oscillation: neuroprotection by intermittent normobaric hyperoxia after transient focal cerebral ischemia in rats. Stroke. 2012;43:220-6 pubmed publisher
    Normobaric hyperoxia (NBO) has been shown to exert neuroprotective effects against cerebral ischemia and to restore penumbral oxygenation...
  24. Almario B, Wu S, Peng J, Alapati D, Chen S, Sosenko I. Pentoxifylline and prevention of hyperoxia-induced lung -injury in neonatal rats. Pediatr Res. 2012;71:583-9 pubmed publisher
    ..The phosphodiesterase inhibitor pentoxifylline (PTX) has anti-inflammatory and antifibrotic effects in multiple organs. It was hypothesized that PTX would have a protective effect on hyperoxia-induced lung injury (HILI).
  25. Lee H, Kim C. Effect of recombinant IL-10 on cultured fetal rat alveolar type II cells exposed to 65%-hyperoxia. Respir Res. 2011;12:68 pubmed publisher
    b>Hyperoxia plays an important role in the genesis of lung injury in preterm infants...
  26. Gortner L, Monz D, Mildau C, Shen J, Kasoha M, Laschke M, et al. Bronchopulmonary dysplasia in a double-hit mouse model induced by intrauterine hypoxia and postnatal hyperoxia: closer to clinical features?. Ann Anat. 2013;195:351-8 pubmed publisher
    ..Recent research focused on mechanisms of lung repair. Animal models of BPD in term rodents use postnatal hyperoxia in order to mimic features observed in very preterm human neonates: reduced alveolarization and impaired septal ..
  27. Tian Z, Li Y, Ji P, Zhao S, Cheng H. Mesenchymal stem cells protects hyperoxia-induced lung injury in newborn rats via inhibiting receptor for advanced glycation end-products/nuclear factor ?B signaling. Exp Biol Med (Maywood). 2013;238:242-7 pubmed publisher
    Bone marrow-derived mesenchymal stem cells (BMSCs) have been shown recently to ameliorate hyperoxia-induced lung injury, but the underlying mechanism remains unclear...
  28. Sørensen A, Peters D, Simonsen C, Pedersen M, Stausbøl Grøn B, Christiansen O, et al. Changes in human fetal oxygenation during maternal hyperoxia as estimated by BOLD MRI. Prenat Diagn. 2013;33:141-5 pubmed publisher
    ..In this study, we aimed to investigate the changes in human fetal oxygenation during maternal hyperoxia by using the non-invasive BOLD MRI technique.
  29. Pilcher J, Weatherall M, Shirtcliffe P, Bellomo R, Young P, Beasley R. The effect of hyperoxia following cardiac arrest - A systematic review and meta-analysis of animal trials. Resuscitation. 2012;83:417-22 pubmed publisher
    There are conflicting findings from observational studies regarding the nature of the association between hyperoxia and risk of mortality in patients admitted to intensive care following cardiac arrest...
  30. Sun S, Lee D, Lee N, Pu J, Wong S, Lui W, et al. Hyperoxia resensitizes chemoresistant human glioblastoma cells to temozolomide. J Neurooncol. 2012;109:467-75 pubmed publisher
    ..In this study, we investigated whether hyperoxia can enhance the TMZ-induced cytotoxicity of human GBM cells, and whether and how it would resensitize TMZ-..
  31. Nagato A, Bezerra F, Lanzetti M, Lopes A, Silva M, Porto L, et al. Time course of inflammation, oxidative stress and tissue damage induced by hyperoxia in mouse lungs. Int J Exp Pathol. 2012;93:269-78 pubmed publisher
    ..this study our aim was to investigate the time courses of inflammation, oxidative stress and tissue damage after hyperoxia in the mouse lung. Groups of BALB/c mice were exposed to 100% oxygen in a chamber for 12, 24 or 48 h...
  32. Wang Q, Yang J, Long C, Zhao J, Li Y, Xue Q, et al. Hyperoxia management during deep hypothermia for cerebral protection in circulatory arrest rabbit model. ASAIO J. 2012;58:330-6 pubmed publisher
    ..The aim of this study was to investigate the possible neuroprotective effects of hyperoxia management during deep hyperthermia for ASCP combined with DHCA in a rabbit model...
  33. You K, Xu X, Fu J, Xu S, Yue X, Yu Z, et al. Hyperoxia disrupts pulmonary epithelial barrier in newborn rats via the deterioration of occludin and ZO-1. Respir Res. 2012;13:36 pubmed publisher
    Prolonged exposure to hyperoxia in neonates can cause hyperoxic acute lung injury (HALI), which is characterized by increased pulmonary permeability and diffuse infiltration of various inflammatory cells...
  34. Chou H, Lang Y, Wang L, Wu T, Hsieh Y, Chen C. Angiotensin II type 1 receptor antagonist attenuates lung fibrosis in hyperoxia-exposed newborn rats. J Pharmacol Exp Ther. 2012;340:169-75 pubmed publisher
    ..Angiotensin II type 1 receptor (AT?R) antagonists and AT?R short interfering RNA diminished hyperoxia-increased collagen expression, whereas AT?R antagonists did not have any effects on these hyperoxia-induced ..
  35. Schmitz T, Endesfelder S, Reinert M, Klinker F, Muller S, Buhrer C, et al. Adolescent hyperactivity and impaired coordination after neonatal hyperoxia. Exp Neurol. 2012;235:374-9 pubmed publisher
    ..on clinical data, higher oxygen levels in preterm infants lead to worse neurological outcome, and experimental hyperoxia causes wide-ranging cerebral changes in neonatal rodents...
  36. Sifringer M, Bendix I, Borner C, Endesfelder S, Von Haefen C, Kalb A, et al. Prevention of neonatal oxygen-induced brain damage by reduction of intrinsic apoptosis. Cell Death Dis. 2012;3:e250 pubmed publisher
    ..Here, we report that elevated oxygen (hyperoxia) triggers a marked increase in active caspase-2 expression, resulting in an initiation of the intrinsic ..
  37. Saugstad O. Hyperoxia in the term newborn: more evidence is still needed for optimal oxygen therapy. Acta Paediatr. 2012;101:34-8 pubmed publisher
    ..There are still a number of unanswered questions related to oxygen therapy of the newborn infant. The newborn brain, lungs and other organs are susceptible to oxygen injury, and newborns still develop injury caused by hyperoxia.
  38. Weichelt U, Cay R, Schmitz T, Strauss E, Sifringer M, Buhrer C, et al. Prevention of hyperoxia-mediated pulmonary inflammation in neonatal rats by caffeine. Eur Respir J. 2013;41:966-73 pubmed publisher
    ..We tested the hypotheses that infant rats exposed to a combination of caffeine and hyperoxia would be less susceptible to lung injury than those exposed to hyperoxia alone and that caffeine decreases the ..
  39. Sutsko R, Young K, Ribeiro A, Torres E, Rodriguez M, Hehre D, et al. Long-term reparative effects of mesenchymal stem cell therapy following neonatal hyperoxia-induced lung injury. Pediatr Res. 2013;73:46-53 pubmed publisher
    Mesenchymal stem cell (MSC) therapy may prevent neonatal hyperoxia-induced lung injury (HILI)...
  40. Velten M, Hutchinson K, Gorr M, Wold L, Lucchesi P, Rogers L. Systemic maternal inflammation and neonatal hyperoxia induces remodeling and left ventricular dysfunction in mice. PLoS ONE. 2011;6:e24544 pubmed publisher
    ..In the present study, we hypothesized that systemic maternal inflammation and neonatal hyperoxia exposure compromise cardiac structure, resulting in LV dysfunction during adulthood.
  41. Porzionato A, Zaramella P, Macchi V, Grisafi D, Salmaso R, Baraldi M, et al. Fluoxetine may worsen hyperoxia-induced lung damage in neonatal rats. Histol Histopathol. 2012;27:1599-610 pubmed publisher
    ..p., during two weeks. Hyperoxia resulted in significant reduction in alveolar density and an increase in pulmonary endocrine cells, as well as ..
  42. Xue L, Ding P, Xiao L, Hu M, Hu Z. Nestin is induced by hypoxia and is attenuated by hyperoxia in Müller glial cells in the adult rat retina. Int J Exp Pathol. 2011;92:377-81 pubmed publisher
    ..cells and astrocytes of the rat retinae, which had been subjected either to hypoxia or to hypoxia followed by hyperoxia treatments. Fifteen rats were used. Ten rats were exposed to 9% O(2) for 2 h...
  43. Ghosh A, Tachtsidis I, Kolyva C, Highton D, Elwell C, Smith M. Normobaric hyperoxia does not change optical scattering or pathlength but does increase oxidised cytochrome C oxidase concentration in patients with brain injury. Adv Exp Med Biol. 2013;765:67-72 pubmed publisher
    ..The patients were subjected to graded normobaric hyperoxia (NBH), with the inspired fraction of oxygen increased from baseline to 60% then 100%...
  44. Zaghloul N, Nasim M, Patel H, Codipilly C, Marambaud P, DEWEY S, et al. Overexpression of extracellular superoxide dismutase has a protective role against hyperoxia-induced brain injury in neonatal mice. FEBS J. 2012;279:871-81 pubmed publisher
    There is increasing evidence that hyperoxia, particularly at the time of birth, may result in neurological injury, in particular to the susceptible vasculature of these tissues...
  45. Usatyuk P, Singleton P, Pendyala S, Kalari S, He D, Gorshkova I, et al. Novel role for non-muscle myosin light chain kinase (MLCK) in hyperoxia-induced recruitment of cytoskeletal proteins, NADPH oxidase activation, and reactive oxygen species generation in lung endothelium. J Biol Chem. 2012;287:9360-75 pubmed publisher
    We recently demonstrated that hyperoxia (HO) activates lung endothelial cell NADPH oxidase and generates reactive oxygen species (ROS)/superoxide via Src-dependent tyrosine phosphorylation of p47(phox) and cortactin...
  46. Yen C, Lai Y, Chen H, Lai C, Lin C, Chen W, et al. Aerosolized human extracellular superoxide dismutase prevents hyperoxia-induced lung injury. PLoS ONE. 2011;6:e26870 pubmed publisher
    ..Female CD-1 mice were exposed in hyperoxia (FiO2>95%) to induce lung injury...
  47. Modun D, Krnic M, Vukovic J, Kokic V, Kukoc Modun L, Tsikas D, et al. Plasma nitrite concentration decreases after hyperoxia-induced oxidative stress in healthy humans. Clin Physiol Funct Imaging. 2012;32:404-8 pubmed publisher
    ..measure plasma nitrite, the biochemical marker of endothelial nitric oxide ((•)NO) synthesis, before and after hyperoxia, in order to test the hypothesis that hyperoxia-induced vasoconstriction is a consequence of reduced ..
  48. Choo Wing R, Syed M, Harijith A, Bowen B, Pryhuber G, Jan r C, et al. Hyperoxia and interferon-?-induced injury in developing lungs occur via cyclooxygenase-2 and the endoplasmic reticulum stress-dependent pathway. Am J Respir Cell Mol Biol. 2013;48:749-57 pubmed publisher
    ..Cox2) and the activation of the endoplasmic reticulum (ER) stress pathway in newborn murine lung on exposure to hyperoxia and IFN-?...
  49. Bozyk P, Bentley J, Popova A, Anyanwu A, Linn M, Goldsmith A, et al. Neonatal periostin knockout mice are protected from hyperoxia-induced alveolar simplication. PLoS ONE. 2012;7:e31336 pubmed publisher
    ..We hypothesized that periostin expression is required for hypoalveolarization and interstitial fibrosis in hyperoxia-exposed neonatal mice, an animal model for this disease...
  50. Morken T, Widerøe M, Vogt C, Lydersen S, Havnes M, Skranes J, et al. Longitudinal diffusion tensor and manganese-enhanced MRI detect delayed cerebral gray and white matter injury after hypoxia-ischemia and hyperoxia. Pediatr Res. 2013;73:171-9 pubmed publisher
    Hypoxia-ischemia (HI) induces delayed inflammation and long-term gray and white matter brain injury that may be altered by hyperoxia.
  51. Werkmeister R, Palkovits S, Told R, Gröschl M, Leitgeb R, Garhofer G, et al. Response of retinal blood flow to systemic hyperoxia as measured with dual-beam bidirectional Doppler Fourier-domain optical coherence tomography. PLoS ONE. 2012;7:e45876 pubmed publisher
    ..These data were compared to data obtained with a laser Doppler velocimeter (LDV)...
  52. Jiang J, Lang Y, Chou H, Shih C, Wu M, Chen C, et al. Activation of the renin-angiotensin system in hyperoxia-induced lung fibrosis in neonatal rats. Neonatology. 2012;101:47-54 pubmed publisher
    Oxygen toxicity plays an important role in lung injury and may lead to bronchopulmonary dysplasia. We previously demonstrated that hyperoxia activated the renin-angiotensin system (RAS) in cultured human fetal lung fibroblasts.
  53. Faller S, Spassov S, Zimmermann K, Ryter S, Buerkle H, Loop T, et al. Hydrogen sulfide prevents hyperoxia-induced lung injury by downregulating reactive oxygen species formation and angiopoietin-2 release. Curr Pharm Des. 2013;19:2715-21 pubmed
    ..However, prolonged exposure to high oxygen concentrations often results in hyperoxia-induced acute lung injury (HALI)...