fever of unknown origin

Summary

Summary: Fever in which the etiology cannot be ascertained.

Top Publications

  1. Ammari F. Fever of unknown origin in North Jordan. Trop Doct. 2006;36:251-3 pubmed
    This is a retrospective study of all patients admitted to Basma Teaching Hospital with a diagnosis of fever of unknown origin (FUO). The study took place from January 1995 to December 2001...
  2. Knockaert D, Vanderschueren S, Blockmans D. Fever of unknown origin in adults: 40 years on. J Intern Med. 2003;253:263-75 pubmed
    A revision of the criteria of fever of unknown origin (FUO), established in 1961, is desirable because of important evolutions in medical practice and the emergence of new patient populations...
  3. Chaturvedi H, Mahanta J, Pandey A. Treatment-seeking for febrile illness in north-east India: an epidemiological study in the malaria endemic zone. Malar J. 2009;8:301 pubmed publisher
    ..This paper studies the determinants of utilization of health care services, especially for treatment of febrile illness in the malaria endemic area of north-east India...
  4. Kei P, Kok T, Padhy A, Ng D, Goh A. [18F] FDG PET/CT in patients with fever of unknown origin: a local experience. Nucl Med Commun. 2010;31:788-92 pubmed publisher
    ..The aim of this study is to assess the value of fluorine [¹?F] FDG PET/CT in the investigation of patients with fever of unknown origin (FUO).
  5. Zangeneh M, Alsadat Mahdavi A, Amini E, Davar Siadat S, Karimian L. Pyomyoma in a premenopausal woman with fever of unknown origin. Obstet Gynecol. 2010;116 Suppl 2:526-8 pubmed publisher
    ..Pyomyoma (suppurative leiomyoma) is a rare disease that is a serious complication. Most cases have occurred in pregnant or postmenopausal women...
  6. Ali Eldin F, Abdelhakam S, Ali Eldin Z. Clinical spectrum of fever of unknown origin among adult Egyptian patients admitted to Ain Shams University Hospitals: a hospital based study. J Egypt Soc Parasitol. 2011;41:379-86 pubmed
    This prospective study was designed to analyze the clinical spectrum of fever of unknown origin (FUO) among adult Egyptian patients admitted to Ain Shams University Hospitals during the period from May 2009 till the end of December 2010...
  7. Masaki Y, Miki M, Sakai T, Sawaki T, Fukushima T, Umehara H. [Intravascular large B-cell lymphoma: an important cause of fever of unknown origin]. Brain Nerve. 2011;63:435-41 pubmed
    Intravascular large B-cell lymphoma (IVLBCL) is an important cause of fever of unknown origin (FUO) and multiple organ failure (MOF)...
  8. Chow A, Robinson J. Fever of unknown origin in children: a systematic review. World J Pediatr. 2011;7:5-10 pubmed publisher
    there are no previous systematic reviews of published pediatric case series describing the etiology of fever of unknown origin (FUO)...
  9. Castaigne C, Tondeur M, De Wit S, Hildebrand M, Clumeck N, Dusart M. Clinical value of FDG-PET/CT for the diagnosis of human immunodeficiency virus-associated fever of unknown origin: a retrospective study. Nucl Med Commun. 2009;30:41-7 pubmed
    ..study was to evaluate retrospectively the usefulness of [18F]fluorodeoxyglucose (FDG)-PET/ computed tomography (CT) in patients affected by human immunodeficiency virus and suffering from fever of unknown origin (HIV-associated FUO).

More Information

Publications62

  1. Kim P, Wu Y, Cooper C, Rochester G, Valappil T, Wang Y, et al. Meta-analysis of a possible signal of increased mortality associated with cefepime use. Clin Infect Dis. 2010;51:381-9 pubmed publisher
    ..To further investigate this possible signal, we accessed findings and data from published and unpublished cefepime clinical trials...
  2. Forshey B, Guevara C, Laguna Torres V, Cespedes M, Vargas J, Gianella A, et al. Arboviral etiologies of acute febrile illnesses in Western South America, 2000-2007. PLoS Negl Trop Dis. 2010;4:e787 pubmed publisher
  3. Lamoth F, Jaton K, Prod hom G, Senn L, Bille J, Calandra T, et al. Multiplex blood PCR in combination with blood cultures for improvement of microbiological documentation of infection in febrile neutropenia. J Clin Microbiol. 2010;48:3510-6 pubmed publisher
    ..Technical adjustments may enhance the efficiency of this new molecular tool in this specific setting...
  4. Dong M, Zhao K, Liu Z, Wang G, Yang S, Zhou G. A meta-analysis of the value of fluorodeoxyglucose-PET/PET-CT in the evaluation of fever of unknown origin. Eur J Radiol. 2011;80:834-44 pubmed publisher
    The diagnosis of patients with fever of unknown origin (FUO) remains a challenging medical problem for internal medicine...
  5. Kim M, Lim G, Kang S, Lee W, Suh J, Lee H. Utility of procalcitonin as an early diagnostic marker of bacteremia in patients with acute fever. Yonsei Med J. 2011;52:276-81 pubmed publisher
    ..The aim of this study was to assess the ability of PCT levels to differentiate bacteremic from nonbacteremic patients with fever. We assessed whether PCT level could be used to accurately rule out a diagnosis of bacteremia...
  6. Kubota K, Nakamoto Y, Tamaki N, Kanegae K, Fukuda H, Kaneda T, et al. FDG-PET for the diagnosis of fever of unknown origin: a Japanese multi-center study. Ann Nucl Med. 2011;25:355-64 pubmed publisher
    To evaluate the clinical value of 2-[(18)F]fluoro-2-deoxy-D: -glucose positron emission tomography (FDG-PET) for the diagnosis of fever of unknown origin (FUO), we performed a Japanese multi-center retrospective survey.
  7. Pelosi E, Skanjeti A, Penna D, Arena V. Role of integrated PET/CT with [¹?F]-FDG in the management of patients with fever of unknown origin: a single-centre experience. Radiol Med. 2011;116:809-20 pubmed publisher
    b>Fever of unknown origin (FUO) is a diagnostic challenge for the wide range of possible causes involved...
  8. Li W, Nie W, Fan R, Qin E, Tu B, Zhao M. [Diagnostic analysis of hospitalized patients with fever of unknown origin at department of infectious diseases]. Zhonghua Yi Xue Za Zhi. 2011;91:604-7 pubmed
    To explore the etiology, diagnostic methods and procedures for patients with fever of unknown origin (FUO) at department of infectious diseases.
  9. Jasper N, Däbritz J, Frosch M, Loeffler M, Weckesser M, Foell D. Diagnostic value of [(18)F]-FDG PET/CT in children with fever of unknown origin or unexplained signs of inflammation. Eur J Nucl Med Mol Imaging. 2010;37:136-45 pubmed publisher
    b>Fever of unknown origin (FUO) and unexplained signs of inflammation are challenging medical problems especially in children and predominantly caused by infections, malignancies or noninfectious inflammatory diseases...
  10. Schattner A, Klepfish A. Left pleural effusion and fever of unknown origin--a clue to thoracic arterial pathology. J Gen Intern Med. 2012;27:1084-7 pubmed publisher
    The subset of patients who have both fever of unknown origin (FUO) and a nondiagnostic pleural effusion on presentation has not been previously investigated...
  11. Freifeld A, Bow E, Sepkowitz K, Boeckh M, Ito J, Mullen C, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america. Clin Infect Dis. 2011;52:e56-93 pubmed publisher
    ..Regardless of venue, clinical vigilance and immediate treatment are the universal keys to managing neutropenic patients with fever and/or infection...
  12. Vanderschueren S, Del Biondo E, Ruttens D, Van Boxelaer I, Wauters E, Knockaert D. Inflammation of unknown origin versus fever of unknown origin: two of a kind. Eur J Intern Med. 2009;20:415-8 pubmed publisher
    A vast literature exists on fever of unknown origin (FUO), characterized by prolonged and perplexing fevers >38.3 degrees C...
  13. Sheng J, Sheng Z, Shen X, Bi S, Li J, Sheng G, et al. Diagnostic value of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in patients with fever of unknown origin. Eur J Intern Med. 2011;22:112-6 pubmed publisher
    While fever of unknown origin (FUO) remains a challenging problem in clinical practice, fluorine-18 fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) has been considered helpful in diagnosing its ..
  14. Moore H, Romeril K. Multiple myeloma presenting with a fever of unknown origin and development of thrombotic thrombocytopenic purpura post-bortezomib. Intern Med J. 2011;41:348-50 pubmed publisher
    Multiple myeloma rarely presents with a fever of unknown origin and diagnosis may be delayed. We describe a case of myeloma presenting in this way with raised serum-free light chains and TP53 deletion on cytogenetics...
  15. Hayakawa K, Ramasamy B, Chandrasekar P. Fever of unknown origin: an evidence-based review. Am J Med Sci. 2012;344:307-16 pubmed
    ..Sustained, unexplained fever despite a comprehensive work up is recognized as fever of unknown origin (FUO), which frequently poses a clinical challenge...
  16. Al Tonbary Y, Soliman O, Sarhan M, Hegazi M, El Ashry R, El Sharkawy A, et al. Nosocomial infections and fever of unknown origin in pediatric hematology/oncology unit: a retrospective annual study. World J Pediatr. 2011;7:60-4 pubmed publisher
    ..This study was undertaken to assess the frequency and patterns of NIs in 1564 pediatric patients and to determine the prevalence of causative organisms and their antimicrobial sensitivity...
  17. Ramsay L, Stany M, Edison J, Bernstein S, Schlegal K, Hamilton C. Gemcitabine-associated large vessel vasculitis presenting as fever of unknown origin. J Clin Rheumatol. 2010;16:181-2 pubmed publisher
    ..We report a case of significant large vessel vasculitis presenting as fever of unknown origin in a patient treated adjuvantly with docetaxel and gemcitabine for uterine leiomyosarcoma...
  18. Balink H, Collins J, Bruyn G, Bruyn G, Gemmel F. F-18 FDG PET/CT in the diagnosis of fever of unknown origin. Clin Nucl Med. 2009;34:862-8 pubmed publisher
    ..A total of 68 patients (33 men, 35 women; age range, 23-91 years) with fever of unknown origin (FUO) underwent a positron emission tomography/computed tomography (PET/CT) scan...
  19. Yago K, Yanagita S, Aono M, Matsuo K, Shimada H. [Usefulness of FDG-PET/CT for the diagnosis of intravascular large B-cell lymphoma presenting with fever of unknown origin and renal dysfunction]. Rinsho Ketsueki. 2009;50:499-502 pubmed
    A 76-year-old man presented with fever of unknown origin and renal dysfunction...
  20. Dimopoulos G, Falagas M. Approach to the febrile patient in the ICU. Infect Dis Clin North Am. 2009;23:471-84 pubmed publisher
    ..Antipyretic therapy must be justified regardless of the metabolic cost (if fever exceeds its physiologic benefit), the result (if the symptomatic relief adversely affects the course of the febrile illness) and the side effects...
  21. Hot A, Jaisson I, Girard C, French M, Durand D, Rousset H, et al. Yield of bone marrow examination in diagnosing the source of fever of unknown origin. Arch Intern Med. 2009;169:2018-23 pubmed publisher
    b>Fever of unknown origin (FUO) still remains a diagnostic challenge, while diagnosis may remain obscure for several weeks or months. The role of tissue biopsy is crucial in the diagnostic approach...
  22. Ciftdogan D, Bayram N, Vardar F. Brucellosis as a cause of fever of unknown origin in children admitted to a tertiary hospital in the Aegean region of Turkey. Vector Borne Zoonotic Dis. 2011;11:1037-40 pubmed publisher
    The aim of the study was to determine the role of brucellosis in children with fever of unknown origin (FUO) in the Aegean region of Turkey...
  23. Baxevanos G, Tzimas T, Pappas G, Akritidis N. A series of 22 patients with adult-onset Still's disease presenting with fever of unknown origin. A difficult diagnosis?. Clin Rheumatol. 2012;31:49-53 pubmed publisher
    ..to investigate how diagnostic criteria apply in a series of 22 new cases of AOSD patients presenting with fever of unknown origin (FUO) and diagnosed at the Internal Medicine Department of Hatzikosta General Hospital of Ioannina, ..
  24. Mukanga D, Tibenderana J, Peterson S, Pariyo G, Kiguli J, Waiswa P, et al. Access, acceptability and utilization of community health workers using diagnostics for case management of fever in Ugandan children: a cross-sectional study. Malar J. 2012;11:121 pubmed publisher
    ..This study assessed household access, acceptability and utilization of community health workers (CHWs) trained and provided with malaria rapid diagnostic tests (RDTs) and respiratory rate timers (RRTs) to practice iCCM...
  25. Baltzell K, Elfving K, Shakely D, Ali A, Msellem M, Gulati S, et al. Febrile illness management in children under five years of age: a qualitative pilot study on primary health care workers' practices in Zanzibar. Malar J. 2013;12:37 pubmed publisher
    ..This pilot study aimed to explore health workers' practices with febrile children and identify factors influencing their diagnostic and management decisions in non-malarial fever patients...
  26. Shi X, Liu X, Zhou B, Zhang L, Ma X, Deng G, et al. Major causes of fever of unknown origin at Peking Union Medical College Hospital in the past 26 years. Chin Med J (Engl). 2013;126:808-12 pubmed
    Despite the recent advances in medicine, fever of unknown origin (FUO) remains a diagnostic and therapeutic challenge even to expert physicians...
  27. Rigante D, Esposito S. A roadmap for fever of unknown origin in children. Int J Immunopathol Pharmacol. 2013;26:315-26 pubmed
    b>Fever of unknown origin (FUO) in adults is conventionally defined by the occurrence of body temperatures above 38...
  28. Chibwana A, Mathanga D, Chinkhumba J, Campbell C. Socio-cultural predictors of health-seeking behaviour for febrile under-five children in Mwanza-Neno district, Malawi. Malar J. 2009;8:219 pubmed publisher
    ..This study assessed socio-cultural factors associated with delayed treatment of children with fever in Mwanza district, Malawi...
  29. Bleeker Rovers C, Van der Meer J, Oyen W. Fever of unknown origin. Semin Nucl Med. 2009;39:81-7 pubmed publisher
    b>Fever of unknown origin (FUO) often is defined as a fever greater than 38.3 degrees C on several occasions during at least 3 weeks with uncertain diagnosis after a number of obligatory tests...
  30. Bleeker S, Moll H. [Young child with fever of unknown origin in the 'post Haemophilus influenzae era']. Ned Tijdschr Geneeskd. 2002;146:3-5 pubmed
    ..Furthermore, careful evaluation, clinical acumen, well-informed parents and observation are all important elements in the treatment of these patients...
  31. Goldschmidt N, Gural A, Kornberg A, Spectre G, Shopen A, Paltiel O. Prolonged fever of unknown origin and hemophagocytosis evolving into acute lymphoblastic leukemia. Am J Hematol. 2004;76:364-7 pubmed
    ..This unusual case demonstrates the importance of cytogenetic abnormalities found in cases of HPS and the importance of repeated testing when an underlying disease is suspected...
  32. Martino R, Viscoli C. Empirical antifungal therapy in patients with neutropenia and persistent or recurrent fever of unknown origin. Br J Haematol. 2006;132:138-54 pubmed
  33. Seshadri N, Solanki C, Balan K. Utility of 111In-labelled leucocyte scintigraphy in patients with fever of unknown origin in an era of changing disease spectrum and investigational techniques. Nucl Med Commun. 2008;29:277-82 pubmed publisher
    111)In-labelled leucocyte, imaging is often used to investigate patients with fever of unknown origin (FUO). Its diagnostic performance, however, has been variable and a broad range of sensitivities and specificities have been reported...
  34. Gosling R, Drakeley C, Mwita A, Chandramohan D. Presumptive treatment of fever cases as malaria: help or hindrance for malaria control?. Malar J. 2008;7:132 pubmed publisher
    ..This fall appears to have started before the widespread introduction of insecticide-treated nets. In the new era of calls to eliminate and eradicate malaria in sub-Saharan Africa, exploring possible causes for this fall seem pertinent...
  35. Cunha B. Fever of unknown origin: clinical overview of classic and current concepts. Infect Dis Clin North Am. 2007;21:867-915, vii pubmed
    b>Fever of unknown origin (FUO) refers to disorders that present with prolonged and perplexing fevers that are difficult to diagnose...
  36. Tsukahara M, Tsuneoka H, Iino H, Murano I, Takahashi H, Uchida M. Bartonella henselae infection as a cause of fever of unknown origin. J Clin Microbiol. 2000;38:1990-1 pubmed
    ..34%) with a serological diagnosis of Bartonella henselae infection were found to have prolonged fever or fever of unknown origin, suggesting that generalized systemic B...
  37. Mueller P, Edson R. Disseminated Mycobacterium abscessus infection manifesting as fever of unknown origin and intra-abdominal lymphadenitis: case report and literature review. Diagn Microbiol Infect Dis. 2001;39:33-7 pubmed
    ..We describe an unusual case of disseminated M. abscessus infection manifesting as fever of unknown origin and intra-abdominal lymphadenitis, but without rash...
  38. Bleeker Rovers C, Corstens F, Van der Meer J, Oyen W. Fever of unknown origin: prospective comparison of diagnostic value of (18)F-FDG PET and (111)In-granulocyte scintigraphy. Eur J Nucl Med Mol Imaging. 2004;31:1342-3; author reply 1344 pubmed
  39. Heussel C, Kauczor H, Heussel G, Fischer B, Begrich M, Mildenberger P, et al. Pneumonia in febrile neutropenic patients and in bone marrow and blood stem-cell transplant recipients: use of high-resolution computed tomography. J Clin Oncol. 1999;17:796-805 pubmed
    ..To obtain statistical data on the use of high-resolution computed tomography (HRCT) for early detection of pneumonia in febrile neutropenic patients with unknown focus of infection...
  40. Baicus C, Bolosiu H, Tanasescu C, Baicus A. [Fever of unknown origin: 1. Etiology. A prospective multicenter study of 164 patients]. Rev Med Chir Soc Med Nat Iasi. 2003;107:545-50 pubmed
    The spectrum of fever of unknown origin seems to be determined by geographic and economic factors, and it appears to change in time...
  41. Arch Ferrer J, Velazquez Fernandez D, Sierra Madero J, Lopez Karpovitch X, Angeles Angeles A, Gamino R, et al. Laparoscopic approach to fever of unknown origin. Surg Endosc. 2003;17:494-7 pubmed
    b>Fever of unknown origin (FUO) is difficult to diagnose. Laparotomy is needed to establish the etiologic diagnosis in some patients...
  42. Akritidis N, Mantzios G, Pappas G. Gallbladder adenomyomatosis presenting as fever of unknown origin: a case report. Hepatogastroenterology. 2001;48:112-3 pubmed
    ..We describe a case of gallbladder adenomyomatosis presenting as fever of unknown origin. The patient was a 17-year-old girl with a history of sustained fever of 38...
  43. Schoffski P, Freund M, Wunder R, Petersen D, Kohne C, Hecker H, et al. Safety and toxicity of amphotericin B in glucose 5% or intralipid 20% in neutropenic patients with pneumonia or fever of unknown origin: randomised study. BMJ. 1998;317:379-84 pubmed
    ..To compare the feasibility of treatment, safety, and toxicity of intravenous amphotericin B deoxycholate prepared in either glucose or intralipid for empirical antimycotic treatment of neutropenic cancer patients...
  44. Baicus C, Bolosiu H, Tanasescu C, Baicus A. [Fever of unknown origin in Romania. II. Diagnostic Procedures. Prospective multicenter study of 164 patients]. Rev Med Chir Soc Med Nat Iasi. 2003;107:772-80 pubmed
    The Diagnostic workup of patients with fever of unknown origin is a challenge, due to the great number of possible etiologies...
  45. Karachalios G, Karachaliou I, Bablekos G, Charalabopoulos K. Fever of unknown origin in carcinoma of the colon. Med Princ Pract. 2004;13:169-70 pubmed
    To report a case of fever of unknown origin in a patient with carcinoma of the colon but without gastrointestinal symptoms.
  46. Cunha B, Syed U, Hamid N. Fever of unknown origin caused by late-onset rheumatoid arthritis. Heart Lung. 2006;35:70-3 pubmed
    b>Fever of unknown origin (FUO) is always a diagnostic challenge. The causes of FUO are legion and may be due to malignancy, infection, collagen vascular disease, and a variety of other unusual disorders...
  47. Pasic S, Minic A, Djuric P, Micic D, Kuzmanovic M, Sarjanovic L, et al. Fever of unknown origin in 185 paediatric patients: a single-centre experience. Acta Paediatr. 2006;95:463-6 pubmed
    We conducted a prospective study to evaluate the causes and outcome in children with fever of unknown origin (FUO).
  48. Miller A, Chacko T, Rashid R, Ledford D. Fever of unknown origin and isolated noncaseating granuloma of the marrow: could this be sarcoidosis?. Allergy Asthma Proc. 2007;28:230-5 pubmed
    b>Fever of unknown origin (FUO) is both a clinical and a diagnostic challenge. Furthermore, an FUO case with isolated marrow noncaseating granuloma can further confound diagnosis...
  49. Zheng M, Lin H, Luo S, Xu L, Zeng Y, Chen Y. Fever of unknown origin in the elderly: nine years experience in China. Trop Doct. 2008;38:221-2 pubmed publisher
    ..to the First and Second Affiliated Hospitals of Wenzhou Medical College, China, with a diagnosis of fever of unknown origin. The study took place from January 1998 to December 2006 among 102 patients who fulfilled the criteria...
  50. Williams J, Bellamy R. Fever of unknown origin. Clin Med (Lond). 2008;8:526-30 pubmed
    ..Most cases are due to unusual presentations of common diseases rather than rare or exotic diseases. The key to establishing the diagnosis is a careful history and careful repeated examinations followed by targeted investigations...
  51. Link H, Bohme A, Cornely O, Hoffken K, Kellner O, Kern W, et al. Antimicrobial therapy of unexplained fever in neutropenic patients--guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO), Study Group Interventional Therapy of Unexplained Fever, Arbeitsg. Ann Hematol. 2003;82 Suppl 2:S105-17 pubmed
    ..After defervescence to <38 degrees C, treatment should be continued for 7 days if the neutrophil count is <1000/microl, and for 2 days if the neutrophil count is >1000/microl...
  52. Andreoni M, Sarmati L, Nicastri E, El Sawaf G, El Zalabani M, Uccella I, et al. Primary human herpesvirus 8 infection in immunocompetent children. JAMA. 2002;287:1295-300 pubmed
    ..Human herpesvirus 8 (HHV-8) infection causes Kaposi sarcoma and lymphoproliferative disorders in immunosuppressed adults. Its manifestations in immunocompetent hosts are unknown...
  53. Landman R, Wardlaw S, McConnell R, Khandji A, Bruce J, Freda P. Pituitary lymphoma presenting as fever of unknown origin. J Clin Endocrinol Metab. 2001;86:1470-6 pubmed
    An 86-yr-old woman presented with fever of unknown origin. When laboratory evaluation revealed partial hypopituitarism, a magnetic resonance imaging scan of the head was performed and revealed a sellar mass consistent with a pituitary ..