signs and symptoms


Summary: Clinical manifestations that can be either objective when observed by a physician, or subjective when perceived by the patient.

Top Publications

  1. Çiçek M, Hascelik G, Müştak H, Diker K, Sener B. [Accurate diagnosis of Pseudomonas luteola in routine microbiology laboratory: on the occasion of two isolates]. Mikrobiyol Bul. 2016;50:621-624 pubmed
    ..In February 2012, a 7-year-old male cystic fibrosis patient who had no signs and symptoms of acute pulmonary exacerbation was admitted to the hospital for a routine control...
  2. Mortaz E, Masjedi M, Abedini A, Matroodi S, Kiani A, Soroush D, et al. Common features of tuberculosis and sarcoidosis. Int J Mycobacteriol. 2016;5 Suppl 1:S240-S241 pubmed publisher
    ..Latent TB is a state in which M. tuberculosis survives in the body without causing overt signs and symptoms. People with latent TB are noncontagious. However, M...
  3. van Weelden M, Viola G, Kozu K, Aikawa N, Ivo C, Silva C. [Disseminated histoplamosis in adolescent mimicking granulomatosis with polyangiitis]. Rev Bras Reumatol. 2015;: pubmed publisher
    ..He was treated with liposomal amphotericin B and itraconazole with improvement of signs and symptoms. We reported a progressive disseminated histoplasmosis case mimicking GPA...
  4. Letsa T, Noora C, Kuma G, Asiedu E, Kye Duodu G, Afari E, et al. Pneumococcal meningitis outbreak and associated factors in six districts of Brong Ahafo region, Ghana, 2016. BMC Public Health. 2018;18:781 pubmed publisher
    ..Mass campaigns on healthy living habits, signs and symptoms of meningitis as well as the need for early reporting were some of the control measures instituted...
  5. Lakatta E. So! What's aging? Is cardiovascular aging a disease?. J Mol Cell Cardiol. 2015;83:1-13 pubmed publisher
    ..Clinical signs and symptoms of these CVDs begin to emerge, however, when the age-associated inflammation in the heart and arteries ..
  6. Maciejko J. Managing Cardiovascular Risk in Lysosomal Acid Lipase Deficiency. Am J Cardiovasc Drugs. 2017;17:217-231 pubmed publisher
    ..The average age of the initial signs and symptoms of the later-onset phenotype is about 5 years old...
  7. Leonardi A, Penta L, Cofini M, Lanciotti L, Principi N, Esposito S. Rhabdomyolysis in a Young Girl with Van Wyk-Grumbach Syndrome due to Severe Hashimoto Thyroiditis. Int J Environ Res Public Health. 2018;15: pubmed publisher
    ..Due to the pleiotropic effects of thyroid hormone, less common signs and symptoms of HT can occur, leading to a delay in diagnosis...
  8. Peter Ross E. Molecular hypotheses to explain the shared pathways and underlying pathobiological causes in catatonia and in catatonic presentations in neuropsychiatric disorders. Med Hypotheses. 2018;113:54-64 pubmed publisher
    ..The first hypothesis postulates that catatonia and the heterogeneity of catatonic signs and symptoms involve nucleolar dysfunction arising from abnormalities of the brain-specific, non-coding micro-RNA, ..
  9. White M, Hunt J, Connell C, Langdon K. Paediatric neurological melioidosis: a rehabilitation case report. Rural Remote Health. 2016;16:3702 pubmed
    ..Associated neurological signs and symptoms (bradykinesia, tremor, dysphagia, aphasia, hypertonia, exotropia) required intensive rehabilitation to ..

More Information


  1. Xu X, Sun Z, Liu J, Zhang J, Liu T, Mu X, et al. Analysis of clinical features and early warning indicators of death from severe fever with thrombocytopenia syndrome. Int J Infect Dis. 2018;73:43-48 pubmed publisher
    ..The differences in demographic characteristics, clinical signs and symptoms, and laboratory parameters in the early stage of disease were compared between the two groups...
  2. Brown G, Brown M, Fischer D. Photopsias: A Key to Diagnosis. Ophthalmology. 2015;122:2084-94 pubmed publisher
    ..stimuli (turning head or eyes, hypoglycemia, hyperglycemia, other); and (9) associated systemic or ocular signs and symptoms (headache, numbness, weakness, vertigo, syncope, diplopia, hypotension, floaters, other)...
  3. Zhu J, Jiang Y, Shi Y, Zheng B, Xu Z, Jia W. Clinical manifestations and treatment outcomes of syphilitic uveitis in HIV-negative patients in China: A retrospective case study. Medicine (Baltimore). 2017;96:e8376 pubmed publisher
    ..However, the clinical signs and symptoms are more insidious in HIV-negative patients who are easily misdiagnosed...
  4. Esposito S, Chidini G, Cinnante C, Napolitano L, Giannini A, Terranova L, et al. Acute flaccid myelitis associated with enterovirus-D68 infection in an otherwise healthy child. Virol J. 2017;14:4 pubmed publisher
    ..After 4 weeks of treatment, the signs and symptoms of AFM were significantly reduced, although some weakness and tingling remained in the patient's four limbs...
  5. Velayati A. Tuberculosis in children. Int J Mycobacteriol. 2016;5 Suppl 1:S1-S2 pubmed publisher
    ..In some cases failure to thrive is represented. Significant signs and symptoms are most common in preschool and adult patients...
  6. Akita S. Lower Extremity Wounds in Patients With Idiopathic Thrombocytopenic Purpura and Systemic Lupus Erythematosus. Int J Low Extrem Wounds. 2015;14:224-30 pubmed publisher
    ..The severe signs and symptoms are the deep skin and soft tissue infections, mainly caused by group A streptococcus, composed of ..
  7. Lichten E. Are the estrogenic hormonal effects of environmental toxins affecting small intestinal bacterial and microfilaria overgrowth?. Med Hypotheses. 2017;109:90-94 pubmed publisher
    ..a mixture of anabolic steroids that raises the FAI and lowers SHBG results in dramatic improvement in the signs and symptoms and recovery of the vast percentage of severe SIBO sufferers the author has treated...
  8. Nie S, Chen G, Cao X, Zhang Y. Cerebrotendinous xanthomatosis: a comprehensive review of pathogenesis, clinical manifestations, diagnosis, and management. Orphanet J Rare Dis. 2014;9:179 pubmed publisher
    ..Clinical signs and symptoms include adult-onset progressive neurological dysfunction (i.e...
  9. Lauwyck J, Piette Y, Van Walleghem L, De Geeter F. IgG4-related disease: The utility of (18)F-FDG PET/CT in diagnosis and treatment. Hell J Nucl Med. 2015;18 Suppl 1:155-9 pubmed
    ..These findings on histopathological specimens are considered the gold standard for the diagnosis. Clinical signs and symptoms largely depend upon organ involvement which can be singular or multiple, synchronous or metachronous...
  10. Batisse A, Grégoire M, Marillier M, Fortias M, Djezzar S. [Cathinones use in Paris]. Encephale. 2016;42:354-60 pubmed publisher
    ..b>Signs and symptoms of toxicity are consistent with a sympathomimetic toxidrome...
  11. Hickey A, Gounder L, Moosa M, Drain P. A systematic review of hepatic tuberculosis with considerations in human immunodeficiency virus co-infection. BMC Infect Dis. 2015;15:209 pubmed publisher
    ..We obtained data on 618 hepatic TB patients from 14 case series. The most common reported signs and symptoms were hepatomegaly (median: 80%, range: 10-100%), fever (median: 67%, range: 30-100), respiratory symptoms (..
  12. Kolinioti A, Tsimaras M, Stravodimos G, Komporozos V. Acute adrenal insufficiency due to adrenal hemorrhage complicating colorectal surgery: Report of two cases and correlation with the antiphospholipid antibody syndrome. Int J Surg Case Rep. 2018;51:90-94 pubmed publisher
    ..b>Signs and symptoms are non-specific and are easily confused with those of the underlying condition...
  13. Mazor R, Manevich Mazor M, Kesler A, Aizenstein O, Eshed I, Jaffe R, et al. Clinical considerations and key issues in the management of patients with Erdheim-Chester Disease: a seven case series. BMC Med. 2014;12:221 pubmed publisher
    ..Prominent signs and symptoms were fever (seven), polyuria and polydipsia (six), ataxia and dysarthria (four), bone pain (four), ..
  14. Namani S, Dreshaj S, Berisha A. Tuberculous meningoencephalitis associated with brain tuberculomas during pregnancy: a case report. J Med Case Rep. 2017;11:175 pubmed publisher
    ..Albanian, pregnant woman living in an urban area in Kosovo, who at 24 weeks of twin pregnancy manifested signs and symptoms of meningoencephalitis with decreased level of consciousness, hemiparesis, and generalized recurrent ..
  15. Cavalcante M, Torres Romero J, Lobo M, Moreno F, Bezerra L, Lima D, et al. A panel of glycoproteins as candidate biomarkers for early diagnosis and treatment evaluation of B-cell acute lymphoblastic leukemia. Biomark Res. 2016;4:1 pubmed publisher
    Acute lymphoblastic leukemia is the most common malignant cancer in childhood. The signs and symptoms of childhood cancer are difficult to recognize, as it is not the first diagnosis to be considered for nonspecific complaints, leading to ..
  16. Minato H, Kinoshita E, Nakada S, Nojima T, Tanaka M, Usuda K, et al. Thymic lymphoid hyperplasia with multilocular thymic cysts diagnosed before the Sjögren syndrome diagnosis. Diagn Pathol. 2015;10:103 pubmed publisher
    ..Lip biopsy showed focal lymphocytic sialadenitis. The signs and symptoms of Sjögren syndrome had not resolved, without aggravation, 1 year after the thymectomy...
  17. Zhang S, Yang J, Jin X, Zhang S. Myocardial infarction, symptomatic third degree atrioventricular block and pulmonary embolism caused by thalidomide: a case report. BMC Cardiovasc Disord. 2015;15:173 pubmed publisher
    ..And it is also important to monitor patients taking thalidomide for signs and symptoms of bradycardia or higher degree atrioventricular block.
  18. de Moura V, da Costa Guimarães N, Batista L, Freitas de Sousa L, de Sousa Martins J, de Souza M, et al. Assessment of the anti-snakebite properties of extracts of Aniba fragrans Ducke (Lauraceae) used in folk medicine as complementary treatment in cases of envenomation by Bothrops atrox. J Ethnopharmacol. 2018;213:350-358 pubmed publisher
    ..appropriate regulations, this species could potentially be used to produce a phytomedicine for complementary treatment of the secondary infections due to bacteria that aggravate the local signs and symptoms after snakebite envenomation.
  19. Kourouklaris A, Ioannou K, Athanasiou I, Panagidou A, Demetriou K, Zavros M. Postpartum thrombotic microangiopathy revealed as atypical hemolytic uremic syndrome successfully treated with eculizumab: a case report. J Med Case Rep. 2014;8:307 pubmed publisher
    ..our patient was readmitted with cardiomyopathy (left ventricular ejection fraction of 25 percent) and signs and symptoms of thrombotic microangiopathy...
  20. Wondwossen Abera -, Waqtola Cheneke -, Gemeda Abebe -. Incidence of antituberculosis-drug-induced hepatotoxicity and associated risk factors among tuberculosis patients in Dawro Zone, South Ethiopia: A cohort study. Int J Mycobacteriol. 2016;5:14-20 pubmed publisher
    ..Raised serum transaminase and bilirubin level, as well as signs and symptoms of hepatotoxicity (nausea, anorexia, vomiting, malaise, and jaundice), were observed in the cases...
  21. Mumtaz F, Khan M, Zubair M, Dehpour A. Neurobiology and consequences of social isolation stress in animal model-A comprehensive review. Biomed Pharmacother. 2018;105:1205-1222 pubmed publisher
    ..During early stages of life, acute or chronic SIS has been proposed to show signs and symptoms of psychiatric and neurological disorders such as anxiety, depression, schizophrenia, epilepsy and memory ..
  22. Lok C. [What's new in clinical dermatology?]. Ann Dermatol Venereol. 2016;143 Suppl 3:S1-S10 pubmed publisher
    ..IBD) and Hidradenitis suppurativa (HS), mostly with Crohn's disease, suggesting the need to look for signs and symptoms of IBD in HS patients...
  23. Garrido D, Garrido S, Gutierrez M, Calvopiña L, Harrison A, Fuseau M, et al. Clinical characterization and antimicrobial resistance of Escherichia coli in pediatric patients with urinary tract infection at a third level hospital of Quito, Ecuador. Bol Med Hosp Infant Mex. 2017;74:265-271 pubmed publisher
    ..Every patient presented urine cultures with the isolation of E. coli that included an antibiogram. Clinical signs and symptoms, urinalysis, complete blood count (CBC) and serum inflammatory markers were analyzed...
  24. Kang B, Park T, Jung J, Ko M, Lee M, Lee J. The Optimal Cut-Off Value of Blood Stasis Syndrome Score in BSS Diagnosis in Korea. Evid Based Complement Alternat Med. 2017;2017:8049481 pubmed publisher diagnose Blood Stasis Syndrome (BSS) in patients, because the diagnosis of BSS is based on the subjective signs and symptoms of patients. This study is aimed at developing the prediction tool of BSS using cut-off value for BSS score...
  25. Havrdova E, Cohen J, Horakova D, Kovárová I, Meluzinova E. Understanding the positive benefit:risk profile of alemtuzumab in relapsing multiple sclerosis: perspectives from the Alemtuzumab Clinical Development Program. Ther Clin Risk Manag. 2017;13:1423-1437 pubmed publisher a timely manner with the monitoring program, which includes physician and patient education about the signs and symptoms, monthly renal and hematologic monitoring, and quarterly thyroid function monitoring for 48 months after the ..
  26. Torkildsen G, Brujic M, Cooper M, Karpecki P, Majmudar P, Trattler W, et al. Evaluation of a new artificial tear formulation for the management of tear film stability and visual function in patients with dry eye. Clin Ophthalmol. 2017;11:1883-1889 pubmed publisher
    ..In this study, we tested a new artificial tear product, Rohto® Dry-Aid™, for its ability to relieve the signs and symptoms of DED. The study used a second drop, Systane® Ultra, as a positive comparator.
  27. Jalnapurkar S, Zarrini P, Mehta P, Thomson L, Agarwal M, Samuels B, et al. Role of Stress Cardiac Magnetic Resonance Imaging in Women with Suspected Ischemia but No Obstructive Coronary Artery Disease. J Radiol Nurs. 2017;36:180-183 pubmed publisher
    b>Signs and symptoms of ischemia but no obstructive coronary artery disease (CAD) is often a diagnostic dilemma in women...
  28. Hertz R, Espinosa J, Lucerna A, Stranges D. Multiple Sclerosis Presenting with Facial Twitching (Myokymia and Hemifacial Spasms). Case Rep Neurol Med. 2017;2017:7180560 pubmed publisher
    ..The most common physical signs and symptoms of MS include constitutional symptoms, muscle weakness, motor and autonomic spinal cord symptoms, ..
  29. Shapiro E, Jones S, Escolar M. Developmental and behavioral aspects of mucopolysaccharidoses with brain manifestations - Neurological signs and symptoms. Mol Genet Metab. 2017;122S:1-7 pubmed publisher
    ..In addition to somatic signs and symptoms, which vary between the different MPS disorders, patients with MPS I, II, III, and VII present with ..
  30. Mahboub B, Vats M, Al Zaabi A, Iqbal M, Safwat T, Al Hurish F, et al. Joint statement for the diagnosis, management, and prevention of chronic obstructive pulmonary disease for Gulf Cooperation Council countries and Middle East-North Africa region, 2017. Int J Chron Obstruct Pulmon Dis. 2017;12:2869-2890 pubmed publisher
    ..of symptoms to "smoker's cough", and the underdiagnosis and undertreatment by physicians because the common signs and symptoms masquerade as asthma. Consequently, there are long-term adverse effects of missing the diagnosis...