corneal endothelial cell loss


Summary: Loss of CORNEAL ENDOTHELIUM usually following intraocular surgery (e.g., cataract surgery) or due to FUCHS' ENDOTHELIAL DYSTROPHY; ANGLE-CLOSURE GLAUCOMA; IRITIS; or aging.

Top Publications

  1. Hazar L, Kara N, Bozkurt E, Ozgurhan E, Demirok A. Intraocular lens implantation procedures in aphakic eyes with insufficient capsular support associated with previous cataract surgery. J Refract Surg. 2013;29:685-91 pubmed publisher
    ..4%) in the RP-IFIOL group, and 135 cells/mm(2) (5.9%) in the AC-IFIOL group (P > 0.05). The study showed that AC-IFIOL, RP-IFIOL, and SF-PCIOL implantation had similar visual outcomes and mean corneal endothelial cell loss.
  2. Teoh L, Foo S, Mansurali V, Ang E, Md Noh U, Bastion M. Evaluation of Corneal Endothelial Cell Loss After Uncomplicated Phacoemulsification Cataract Surgery With Intracameral Phenylephrine. Asia Pac J Ophthalmol (Phila). 2017;6:318-325 pubmed publisher
    To study the effects of intracameral phenylephrine 1.5% on corneal endothelial cell loss and morphological changes in patients who had uneventful phacoemulsification surgery. A double-blind randomized controlled trial...
  3. Núñez Álvarez C, Del Olmo Aguado S, Merayo Lloves J, Osborne N. Near infra-red light attenuates corneal endothelial cell dysfunction in situ and in vitro. Exp Eye Res. 2017;161:106-115 pubmed publisher
    ..The study provides proof of principle for the non-invasive use of red-light therapy to attenuate any dysfunctions associated with the corneal endothelium and so preserve maximum visual acuity. ..
  4. Hamoudi H, Christensen U, la Cour M. Corneal endothelial cell loss and corneal biomechanical characteristics after two-step sequential or combined phaco-vitrectomy surgery for idiopathic epiretinal membrane. Acta Ophthalmol. 2017;95:493-497 pubmed publisher
    ..Combined and sequential surgery in ERM leads to a small decrease in CED. Performing cataract surgery before, after or in combination with vitrectomy did not make any significant difference with respect to final CED, CCT or CV. ..
  5. Margo J, Whiting M, Brown C, Hoover C, Munir W. The Effect of Chronic Pulmonary Disease and Mechanical Ventilation on Corneal Donor Endothelial Cell Density and Transplant Suitability. Am J Ophthalmol. 2017;183:65-70 pubmed publisher
    ..Donors with COPD and donors who were mechanically ventilated had reduced cell counts. Longer ventilation times lead to increased cell loss. The presence of respiratory disease may affect tissue oxygenation and endothelial cell health. ..
  6. Bhogal M, Lwin C, Seah X, Murugan E, Adnan K, Lin S, et al. Real-time assessment of corneal endothelial cell damage following graft preparation and donor insertion for DMEK. PLoS ONE. 2017;12:e0184824 pubmed publisher
    ..To establish a method for assessing graft viability, in-vivo, following corneal transplantation...
  7. Zhong J, Jia J, Yu J, Zhang L, Xiang Y. Preoperative photocoagulation reduces corneal endothelial cell damage after vitrectomy in patients with proliferative diabetic retinopathy. Medicine (Baltimore). 2017;96:e7971 pubmed publisher
    ..05).Photocoagulation before vitrectomy reduces subsequent corneal endothelial cell damage in PDR patients. ..
  8. Ham L, Dapena I, van der Wees J, Melles G. Endothelial cell density after descemet membrane endothelial keratoplasty: 1- to 3-year follow-up. Am J Ophthalmol. 2010;149:1016-7 pubmed publisher
  9. Lange C, Böhringer D, Reinhard T. Corneal endothelial loss after crosslinking with riboflavin and ultraviolet-A. Graefes Arch Clin Exp Ophthalmol. 2012;250:1689-91 pubmed publisher

More Information


  1. Labiris G, Sideroudi H, Rousopoulos K, Kozobolis V. Cohesive versus dispersive-cohesive ophthalmic viscosurgical device in torsional intelligent phaco. J Cataract Refract Surg. 2015;41:681-2 pubmed publisher
  2. Guechi O, Lhuillier L, Houmad N, Goetz C, Ouamara N, Perone J. Visual outcomes following Descemet stripping automated endothelial keratoplasty for corneal endothelial dysfunction. Eur J Ophthalmol. 2017;27:513-519 pubmed publisher
    ..Further large-scale study is needed to corroborate these findings. ..
  3. Yagi Yaguchi Y, Yamaguchi T, Higa K, Suzuki T, Yazu H, Aketa N, et al. Preoperative Aqueous Cytokine Levels Are Associated With a Rapid Reduction in Endothelial Cells After Penetrating Keratoplasty. Am J Ophthalmol. 2017;181:166-173 pubmed publisher
    ..05). Higher preoperative levels of IL-10, MCP-1, and IFN-? in the AqH were associated with low ECD after PKP. ..
  4. Lobo A, Rhee D. Delayed interval of involvement of the second eye in a male patient with bilateral Chandler's syndrome. Br J Ophthalmol. 2012;96:134-5, 146-7 pubmed publisher
  5. Heindl L, Riss S, Adler W, Steven P, Hos D, Cursiefen C. Corneal graft alterations after Descemet stripping: implications for split cornea transplantation. JAMA Ophthalmol. 2013;131:687-9 pubmed publisher
  6. Toda M, Ueno M, Hiraga A, Asada K, Montoya M, Sotozono C, et al. Production of Homogeneous Cultured Human Corneal Endothelial Cells Indispensable for Innovative Cell Therapy. Invest Ophthalmol Vis Sci. 2017;58:2011-2020 pubmed publisher
    ..Our findings elucidated the culture conditions needed to obtain reproducible cHCECs with high E-ratios, thus ensuring homogeneous cHCECs with matured functions for the treatment of corneal endothelial dysfunction. ..