Summary: The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement.

Top Publications

  1. Secchiero P, Zauli G. TRAIL, a new weapon against neointimal hyperplasia. Cardiology. 2012;123:94-6 pubmed publisher
  2. Yu B, Kiechl S, Qi D, Wang X, Song Y, Weger S, et al. A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective. Circulation. 2017;136:1022-1036 pubmed publisher
    ..we analyzed the area of atherosclerotic lesions, femoral artery injury-induced reendothelialization, and neointima formation in both DKK3-/-/apolipoprotein E-/- and DKK3<..
  3. Alpers C, Imrey P, Hudkins K, Wietecha T, Radeva M, Allon M, et al. Histopathology of Veins Obtained at Hemodialysis Arteriovenous Fistula Creation Surgery. J Am Soc Nephrol. 2017;28:3076-3088 pubmed publisher
    ..b>Neointima occupied >20% of the lumen in 57% of fully circumferential vein samples, and neointimal hyperplasia ..
  4. Leopold J. Neoatherosclerosis: another consequence of endothelial dysfunction?. Circ Cardiovasc Interv. 2014;7:635-7 pubmed publisher
  5. Cheng W, She Z, Qin J, Guo J, Gong F, Zhang P, et al. Interferon Regulatory Factor 4 Inhibits Neointima Formation by Engaging Krüppel-Like Factor 4 Signaling. Circulation. 2017;136:1412-1433 pubmed publisher
    The mechanisms underlying neointima formation remain unclear. Interferon regulatory factors (IRFs), which are key innate immune regulators, play important roles in cardiometabolic diseases...
  6. He Y, Xu X, Zhu T, Tang M, Mei J, Si Y. Resident Arterial Cells and Circulating Bone Marrow-Derived Cells both Contribute to Intimal Hyperplasia in a Rat Allograft Carotid Transplantation Model. Cell Physiol Biochem. 2017;42:1303-1312 pubmed publisher
    ..Smooth muscle actin (SMA)-positive and CD68-positive cells were clearly observed 14 days later in the neointima after allograft transplantation of the balloon-injured carotid common artery, where re-endothelialization was ..
  7. Choe N, Kwon D, Shin S, Kim Y, Kim Y, Kim J, et al. The microRNA miR-124 inhibits vascular smooth muscle cell proliferation by targeting S100 calcium-binding protein A4 (S100A4). FEBS Lett. 2017;591:1041-1052 pubmed publisher
    ..Our findings suggest that miR-124 is a novel regulator of VSMC proliferation and may play a role in the development of neointimal proliferation. ..
  8. Dutzmann J, Musmann R, Haertlé M, Daniel J, Sonnenschein K, Schafer A, et al. The novel mineralocorticoid receptor antagonist finerenone attenuates neointima formation after vascular injury. PLoS ONE. 2017;12:e0184888 pubmed publisher
    ..of ECs and simultaneously attenuates SMC proliferation, resulting in accelerated endothelial healing and reduced neointima formation of the injured vessels...
  9. Hubert A, Bochenek M, Schütz E, Gogiraju R, Munzel T, Schafer K. Selective Deletion of Leptin Signaling in Endothelial Cells Enhances Neointima Formation and Phenocopies the Vascular Effects of Diet-Induced Obesity in Mice. Arterioscler Thromb Vasc Biol. 2017;37:1683-1697 pubmed publisher
    ..Leptin receptors (LepRs) are expressed on endothelial cells, and leptin promotes neointima formation in a receptor-dependent manner. Our aim was to examine the importance of endothelial LepR (End...

More Information


  1. Xia J, Qu Y, Yin C, Xu D. Optical Coherence Tomography Assessment of Glucose Fluctuation Impact on the Neointimal Proliferation After Stent Implantation in a Diabetic/Hypercholesterolemic Swine Model. Int Heart J. 2017;58:608-614 pubmed publisher
    ..The extent of glucose fluctuation may be related to the degree of neointimal proliferation and this needs to be further confirmed by long-term follow-up and histology. ..
  2. Kala P, Kanovsky J, Novakova T, Miklik R, Bocek O, Poloczek M, et al. Radial artery neointimal hyperplasia after transradial PCI-Serial optical coherence tomography volumetric study. PLoS ONE. 2017;12:e0185404 pubmed publisher
    ..In this investigation the aim was to assess the intimal changes of RA using the optical coherence tomography (OCT) intravascular imaging in a serial manner...
  3. Xie Y, Potter C, Le Bras A, Nowak W, Gu W, Bhaloo S, et al. Leptin Induces Sca-1+ Progenitor Cell Migration Enhancing Neointimal Lesions in Vessel-Injury Mouse Models. Arterioscler Thromb Vasc Biol. 2017;37:2114-2127 pubmed publisher
    ..Guidewire injury could only induce minor neointima in Lepr-/- mice 2 weeks post-surgery...
  4. Zhu T, He Y, Yang J, Fu W, Xu X, Si Y. MYBPH inhibits vascular smooth muscle cell migration and attenuates neointimal hyperplasia in a rat carotid balloon-injury model. Exp Cell Res. 2017;359:154-162 pubmed publisher
    ..In this study, we sought to determine whether MYBPH is involved in VSMC migration and neointima formation in response to vascular injury...
  5. van Ditzhuijzen N, Kurata M, van den Heuvel M, Sorop O, van Duin R, Krabbendam Peters I, et al. Neoatherosclerosis development following bioresorbable vascular scaffold implantation in diabetic and non-diabetic swine. PLoS ONE. 2017;12:e0183419 pubmed publisher
    ..20) and not associated with DM or inflammation. Scaffold coverage showed signs of neo-atherosclerosis in all FF-DM and FF-NDM swine, scaffold polymer was preserved and the vascular response to BVS was not influenced by diabetes. ..
  6. Li Z, Li M, Li X, Zhang M, Zhao Y, Ren W, et al. Hyperbaric oxygen inhibits venous neointimal hyperplasia following arteriovenous fistulization. Int J Mol Med. 2017;39:1299-1306 pubmed publisher
    ..Our results thus suggest that continuous HBO treatment following AVF significantly inhibits VNH and promotes blood flow. Therefore, early AVF failure may be prevented by the use of HBO therapy. ..
  7. Lu Y, Lowery A, Sun L, Singer H, Dai G, Adam A, et al. Endothelial Myocyte Enhancer Factor 2c Inhibits Migration of Smooth Muscle Cells Through Fenestrations in the Internal Elastic Lamina. Arterioscler Thromb Vasc Biol. 2017;37:1380-1390 pubmed publisher
    ..These results indicate that endothelial Mef2c regulates the endothelial actin cytoskeleton and inhibits smooth muscle cell migration into the intima. ..
  8. Jin E, Han S, Son M, Kim S. Cordyceps bassiana inhibits smooth muscle cell proliferation via the ERK1/2 MAPK signaling pathway. Cell Mol Biol Lett. 2016;21:24 pubmed publisher
    ..In conclusion, CBEE exhibited anti-proliferative properties that affected VSMCs through the ERK1/2 MAPK signaling pathway. Our data may elucidate the inhibitory mechanism of this natural product. ..
  9. Zhang J, Lei L, Shang J, Huo T, Zhang B, Chen G, et al. Local application of paeonol prevents early restenosis: a study with a rabbit vein graft model. J Surg Res. 2017;212:278-287 pubmed publisher
    ..001). Paeonol could prevent vein graft early restenosis by suppressing intimal and medial hyperplasia via inhibition of vascular smooth muscle cells proliferation, VCAM-1 expression, and anti-apoptosis of VECs in grafted veins. ..
  10. Santulli G, Wronska A, Uryu K, Diacovo T, Gao M, Marx S, et al. A selective microRNA-based strategy inhibits restenosis while preserving endothelial function. J Clin Invest. 2014;124:4102-14 pubmed publisher
    ..Our proof-of-principle study demonstrates the potential of using a miRNA-based strategy as a therapeutic approach to specifically inhibit vascular restenosis while preserving EC function. ..
  11. Maguire E, Xiao Q, Xu Q. Differentiation and Application of Induced Pluripotent Stem Cell-Derived Vascular Smooth Muscle Cells. Arterioscler Thromb Vasc Biol. 2017;37:2026-2037 pubmed publisher
  12. Singh N, Janjanam J, Rao G. p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine-induced vascular smooth muscle cell migration and proliferation. J Biol Chem. 2017;292:14080-14091 pubmed publisher
    ..levels substantially attenuated BI-induced smooth muscle cell migration and proliferation, resulting in reduced neointima formation...
  13. Komatsu T, Yaguchi I, Komatsu S, Nakahara S, Kobayashi S, Sakai Y, et al. Impact of Insulin Resistance on Neointimal Tissue Proliferation after 2nd-Generation Drug-Eluting Stent Implantation. Tex Heart Inst J. 2015;42:327-32 pubmed publisher
    ..037), and the mean late lumen loss was larger (0.4 ± 0.48 vs 0.16 ± 0.21 mm; P=0.025). These results suggest that insulin resistance affects neointimal tissue proliferation after 2nd-generation drug-eluting stent implantation. ..
  14. Huang X, Wang X, Zou Y, Chen S, Zhang R, Li L, et al. Impact of Cigarette Smoking and Smoking Cessation on Stent Changes as Determined by Optical Coherence Tomography After Sirolimus Stent Implantation. Am J Cardiol. 2017;120:1279-1284 pubmed publisher
    ..04?±?0.72?mm2 vs 0.96?±?0.68?mm2; p?=?0.04). The incidence of lipid-laden neointima was lower in SC?>?1Y patients (1.6%) than in all other patients (NS: 3.9%, p?=?0.002; CS: 3.0%, p?=?0...
  15. Wu B, Li Y, Ong K, Sun Y, Shrestha S, Hou L, et al. Reduction of In-Stent Restenosis by Cholesteryl Ester Transfer Protein Inhibition. Arterioscler Thromb Vasc Biol. 2017;37:2333-2341 pubmed publisher
  16. Liu R, Heiss E, Schachner D, Jiang B, Liu W, Breuss J, et al. Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cells in Vitro and Reduces Neointima Formation in Vivo. J Nat Prod. 2017;80:2146-2150 pubmed publisher
    ..vascular smooth muscle cell (VSMC) proliferation and migration in vitro and on experimentally induced neointima formation in vivo...
  17. Wang Y, Cui X, Chuang Y, Chen S. Janus Kinase 3, a Novel Regulator for Smooth Muscle Proliferation and Vascular Remodeling. Arterioscler Thromb Vasc Biol. 2017;37:1352-1360 pubmed publisher
    ..In vivo, knockdown of JAK3 attenuates injury-induced neointima formation with attenuated neointimal SMC proliferation...
  18. Haase N, Rüder C, Haase H, Kamann S, Kouno M, Morano I, et al. Protective Function of Ahnak1 in Vascular Healing after Wire Injury. J Vasc Res. 2017;54:131-142 pubmed publisher
    ..The large scaffold and adaptor proteins Ahnak1 and Ahnak2 exhibit differential expression patterns and functions in naïve and injured arteries. Ahnak1 plays a nonredundant protective role in vascular healing. ..
  19. Lee S, Ahn J, Mintz G, Hur S, Choi S, Kim S, et al. Characteristics of Earlier Versus Delayed Presentation of Very Late Drug-Eluting Stent Thrombosis: An Optical Coherence Tomographic Study. J Am Heart Assoc. 2017;6: pubmed publisher
    ..The pathological mechanisms of very late DES thrombosis changed over time. Delayed neointimal healing remained a substantial substrate for VLST, even long after DES implantation. ..
  20. Murase S, Suzuki Y, Yamaguchi T, Matsuda O, Murata A, Ito T. The relationship between re-endothelialization and endothelial function after DES implantation: comparison between paclitaxcel eluting stent and zotarolims eluting stent. Catheter Cardiovasc Interv. 2014;83:412-7 pubmed
    ..Our findings suggest that endothelial function seems to be better preserved with ZES than PES, and homogeneous neointimal coverage of stent struts seem to be associated with the preserved endothelial function. ..
  21. Jinnouchi H, Inoue K, Soga Y, Tomoi Y, Kobayashi Y, Hiramori S, et al. Pathology of Neointimal Calcification in Very Late Restenosis After Bare Metal Stent Implantation for Superficial Femoral Artery. Int Heart J. 2017;58:641-644 pubmed publisher
    ..femoral artery, marked calcification was observed in the entire circumference of the luminal surface of the neointima. However, lipid core formation was not identified in the neointima...
  22. Romero M, Yahagi K, Kolodgie F, Virmani R. Neoatherosclerosis From a Pathologist's Point of View. Arterioscler Thromb Vasc Biol. 2015;35:e43-9 pubmed publisher
  23. Keiler J, Schulze M, Sombetzki M, Heller T, Tischer T, Grabow N, et al. Neointimal fibrotic lead encapsulation - Clinical challenges and demands for implantable cardiac electronic devices. J Cardiol. 2017;70:7-17 pubmed publisher
    ..The published data on the coherences and issues related to lead associated vascular fibrosis and neointimal lead encapsulation are reviewed and discussed in this paper. ..
  24. Jourd heuil F, Xu H, Reilly T, McKellar K, El Alaoui C, Steppich J, et al. The Hemoglobin Homolog Cytoglobin in Smooth Muscle Inhibits Apoptosis and Regulates Vascular Remodeling. Arterioscler Thromb Vasc Biol. 2017;37:1944-1955 pubmed publisher delivery of adenovirus encoding shRNA specific for CYGB prevented its reexpression and decreased neointima formation...
  25. McRobb L, McGrath K, Tsatralis T, Liong E, Tan J, Hughes G, et al. Estrogen Receptor Control of Atherosclerotic Calcification and Smooth Muscle Cell Osteogenic Differentiation. Arterioscler Thromb Vasc Biol. 2017;37:1127-1137 pubmed publisher
  26. Bhatwadekar A, Beli E, Diao Y, Chen J, Luo Q, Alex A, et al. Conditional Deletion of Bmal1 Accentuates Microvascular and Macrovascular Injury. Am J Pathol. 2017;187:1426-1435 pubmed publisher
  27. Indolfi C, Mongiardo A, Spaccarotella C, Caiazzo G, Torella D, De Rosa S. Neointimal proliferation is associated with clinical restenosis 2 years after fully bioresorbable vascular scaffold implantation. Circ Cardiovasc Imaging. 2014;7:755-7 pubmed publisher
  28. Kashiwagi M, Tanaka A, Kitabata H, Ino Y, Tsujioka H, Komukai K, et al. OCT-verified neointimal hyperplasia is increased at fracture site in drug-eluting stents. JACC Cardiovasc Imaging. 2012;5:232-3 pubmed publisher
  29. Zhang L, Chen Q, An W, Yang F, Maguire E, Chen D, et al. Novel Pathological Role of hnRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia. Arterioscler Thromb Vasc Biol. 2017;37:2182-2194 pubmed publisher
    ..little is known about the functional involvement of hnRNPA1 in vascular smooth muscle cell (VSMC) function and neointima hyperplasia...