oligomenorrhea

Summary

Summary: Abnormally infrequent menstruation.

Top Publications

  1. Bieniasz J, Zak T, Laskowska Zietek A, Noczynska A. [Causes of menstrual disorders in adolescent girls--a retrospective study]. Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2006;12:205-10 pubmed
  2. Ibanez L, Lopez Bermejo A, Diaz M, Marcos M, de Zegher F. Early metformin therapy (age 8-12 years) in girls with precocious pubarche to reduce hirsutism, androgen excess, and oligomenorrhea in adolescence. J Clin Endocrinol Metab. 2011;96:E1262-7 pubmed publisher
    ..Girls with a combined history of low(-normal) birth weight (LBW) and precocious pubarche (PP) are at high risk to develop polycystic ovary syndrome (PCOS)...
  3. Fleming R, Hopkinson Z, Wallace A, Greer I, Sattar N. Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial. J Clin Endocrinol Metab. 2002;87:569-74 pubmed
    Women with oligomenorrhea and polycystic ovaries show a high incidence of ovulation failure perhaps linked to insulin resistance and related metabolic features...
  4. Joffe H, Cohen L, Suppes T, McLaughlin W, Lavori P, Adams J, et al. Valproate is associated with new-onset oligoamenorrhea with hyperandrogenism in women with bipolar disorder. Biol Psychiatry. 2006;59:1078-86 pubmed
    ..The development of PCOS features after initiation of valproate was therefore examined in women with bipolar disorder using a standardized definition of PCOS...
  5. Trutschnigg B, Chong C, Habermayerova L, Karelis A, Komorowski J. Female boxers have high bone mineral density despite low body fat mass, high energy expenditure, and a high incidence of oligomenorrhea. Appl Physiol Nutr Metab. 2008;33:863-9 pubmed publisher
    ..007) than that of controls (boxers, 5748 +/- 2284 ; C1, 2966 +/- 2258 ; C2, 2714 +/- 1722 kcal.week-1). Oligomenorrhea was more common in boxers than in C1 and C2 subjects (boxers, 54.6%; C1, 18.8%; C2, 35.3%)...
  6. Glueck C, Morrison J, Wang P, Woo J. Early and late menarche are associated with oligomenorrhea and predict metabolic syndrome 26 years later. Metabolism. 2013;62:1597-606 pubmed publisher
    We determined whether simple, clinical information on late and early menarche could help identify adult women with metabolic syndrome (MetS) and oligomenorrhea.
  7. Ibanez L, Potau N, Marcos M, de Zegher F. Treatment of hirsutism, hyperandrogenism, oligomenorrhea, dyslipidemia, and hyperinsulinism in nonobese, adolescent girls: effect of flutamide. J Clin Endocrinol Metab. 2000;85:3251-5 pubmed
    ..However, flutamide failed to increase high-density lipoprotein cholesterol levels or decrease hyperinsulinemia, i.e. to affect two major risk factors for subsequent cardiovascular disease...
  8. Ibanez L, Valls C, Potau N, Marcos M, de Zegher F. Sensitization to insulin in adolescent girls to normalize hirsutism, hyperandrogenism, oligomenorrhea, dyslipidemia, and hyperinsulinism after precocious pubarche. J Clin Endocrinol Metab. 2000;85:3526-30 pubmed
    ..in girls is often preceded by low weight at birth and followed by hirsutism, ovarian hyperandrogenism, and oligomenorrhea in adolescence, the latter usually being accompanied by dyslipidemia and hyperinsulinism, which are, in turn, ..
  9. Taponen S, Martikainen H, Jarvelin M, Sovio U, Laitinen J, Pouta A, et al. Metabolic cardiovascular disease risk factors in women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland Birth Cohort 1966 Study. J Clin Endocrinol Metab. 2004;89:2114-8 pubmed
    The metabolic cardiovascular disease (CVD) risk factors of women with self-reported oligomenorrhea and/or hirsutism, which are symptoms of polycystic ovary syndrome (PCOS), were investigated in a general population-based Northern Finland ..

More Information

Publications62

  1. Rickenlund A, Carlstrom K, Ekblom B, Brismar T, von Schoultz B, Hirschberg A. Hyperandrogenicity is an alternative mechanism underlying oligomenorrhea or amenorrhea in female athletes and may improve physical performance. Fertil Steril. 2003;79:947-55 pubmed
    To evaluate endocrine mechanisms underlying oligomenorrhea or amenorrhea in female athletes.
  2. Taponen S, Martikainen H, Jarvelin M, Laitinen J, Pouta A, Hartikainen A, et al. Hormonal profile of women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland birth cohort 1966 study. J Clin Endocrinol Metab. 2003;88:141-7 pubmed
    ..of nested female patients (n = 500) with self-reported symptoms typical of polycystic ovary syndrome (PCOS), oligomenorrhea, and/or hirsutism and their randomly selected controls (n = 1026) at the age of 31 yr were analyzed in a ..
  3. De Pergola G, Tartagni M, D Angelo F, Centoducati C, Guida P, Giorgino R. Abdominal fat accumulation, and not insulin resistance, is associated to oligomenorrhea in non-hyperandrogenic overweight/obese women. J Endocrinol Invest. 2009;32:98-101 pubmed
    ..The aim of this study was to evaluate the prevalence of oligomenorrhea in uncomplicated obesity, and to examine whether this menstrual alteration is associated with anthropometric, ..
  4. Yuan H, Wang C, Sze C, Tong Y, Tan Q, Feng X, et al. A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. J Clin Psychopharmacol. 2008;28:264-370 pubmed publisher
    ..treatment, diagnosed with hyperprolactinemia (serum PRL levels >50 mug/L), and currently experiencing oligomenorrhea or amenorrhea were selected for the study...
  5. Gerli S, Mignosa M, Di Renzo G. Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial. Eur Rev Med Pharmacol Sci. 2003;7:151-9 pubmed
    Women with oligomenorrhea and polycystic ovaries show a high incidence of ovulation failure perhaps linked to insulin resistance and related metabolic features. A small number of reports shows that inositol improves ovarian function...
  6. Masha A, Manieri C, DiNatale S, Bruno G, Ghigo E, Martina V. Prolonged treatment with N-acetylcysteine and L-arginine restores gonadal function in patients with polycystic ovary syndrome. J Endocrinol Invest. 2009;32:870-2 pubmed publisher
    ..42 vs 3.48, 1.62-5.95; p<0.05). In conclusion, this preliminary, open study suggests that prolonged treatment with NAC+ARG might restore gonadal function in PCOS. This effect seems associated to an improvement in insulin sensitivity...
  7. Strowitzki T, Capp E, von Eye Corleta H. The degree of cycle irregularity correlates with the grade of endocrine and metabolic disorders in PCOS patients. Eur J Obstet Gynecol Reprod Biol. 2010;149:178-81 pubmed publisher
    ..The aim of this study was to evaluate possible correlations between the degree of cycle irregularity and the grade of endocrine and metabolic abnormalities...
  8. Chun Sen H, Chien Hua W, Wan Chun C, Ching Tzu L, Chun Jen C, Ming I H. Obesity and insulin resistance in women with polycystic ovary syndrome. Gynecol Endocrinol. 2011;27:300-6 pubmed publisher
    ..To evaluate the impact of obesity and various phenotypes of polycystic ovary syndrome (PCOS) on the insulin sensitivity index (ISI) and insulin resistance (IR)...
  9. Rabøl R, Svendsen P, Skovbro M, Boushel R, Schjerling P, Nilas L, et al. Skeletal muscle mitochondrial function in polycystic ovarian syndrome. Eur J Endocrinol. 2011;165:631-7 pubmed publisher
    ..We measured mitochondrial respiration in lean and obese women with and without PCOS using high-resolution respirometry...
  10. Alemzadeh R, Kansra A. New adolescent polycystic ovary syndrome perspectives. Minerva Pediatr. 2011;63:35-47 pubmed
    ..endocrine disorder is associated with chronic anovulation and hyperandrogenemia with clinical manifestation of oligomenorrhea, hirsutism and acne...
  11. Rudnicka E, Wierzba W, Radowicki S. [Evaluation of endometrial histologic morphology in patients with polycystic ovary syndrome]. Ginekol Pol. 2009;80:103-6 pubmed
    ..To evaluate endometrial histologic morphology in patients with polycystic ovary syndrome...
  12. Vera L, Accornero M, Mora M, Valenzano Menada M, Minuto F, Giusti M. Increasing hirsutism due to a granulosa-cell tumor in a woman with polycystic ovary syndrome: case report and review of the literature. Gynecol Endocrinol. 2013;29:273-7 pubmed publisher
    ..These tumors present with an endocrine syndrome and mass signs. Surgery is the primary treatment approach. The risk of recurrence is more frequent in the juvenile-onset form...
  13. Polotsky A, Allshouse A, Crawford S, Harlow S, Khalil N, Kazlauskaite R, et al. Hyperandrogenic oligomenorrhea and metabolic risks across menopausal transition. J Clin Endocrinol Metab. 2014;99:2120-7 pubmed publisher
    ..Although there is evidence of metabolic risks in young women with irregular menses and androgen excess, persistence of risks after menopause is unclear...
  14. Nezi M, Christopoulos P, Paltoglou G, Gryparis A, Bakoulas V, Deligeoroglou E, et al. Focus on BMI and subclinical hypothyroidism in adolescent girls first examined for amenorrhea or oligomenorrhea. The emerging role of polycystic ovary syndrome. J Pediatr Endocrinol Metab. 2016;29:693-702 pubmed publisher
    Primary amenorrhea, oligomenorrhea and secondary amenorrhea are diagnosed commonly during adolescence. Weight aberrations are associated with menstrual disorders. Autoimmune thyroiditis is frequent during adolescence...
  15. Drenthen W, Hoendermis E, Moons P, Heida K, Roos Hesselink J, Mulder B, et al. Menstrual cycle and its disorders in women with congenital heart disease. Congenit Heart Dis. 2008;3:277-83 pubmed publisher
    ..To investigate the age at menarche, the prevalence of menstrual cycle (interval) disorders, and determinants in women with congenital heart disease (CHD)...
  16. Franks S, Webber L, Goh M, Valentine A, White D, Conway G, et al. Ovarian morphology is a marker of heritable biochemical traits in sisters with polycystic ovaries. J Clin Endocrinol Metab. 2008;93:3396-402 pubmed publisher
    ..Polycystic ovary syndrome (PCOS) is a common endocrinopathy of uncertain etiology but with strong evidence for a genetic contribution...
  17. Ramsay R, Wolman R. Are synchronised swimmers at risk of amenorrhoea?. Br J Sports Med. 2001;35:242-4 pubmed
    ..The purpose of this investigation was to ascertain whether the highest ranked synchronised swimmers in the United Kingdom experience menstrual abnormalities, a common medical problem seen in these related activities...
  18. Nichols J, Rauh M, Barrack M, Barkai H, Pernick Y. Disordered eating and menstrual irregularity in high school athletes in lean-build and nonlean-build sports. Int J Sport Nutr Exerc Metab. 2007;17:364-77 pubmed
    ..3, 95%CI: 1.3, 4.2) to report oligo/amenorrhea than athletes without DE. These data establish an association between DE and MI among high school athletes and indicate that LB athletes have more MI but not DE than NLB athletes...
  19. Stephens J, Fielding A, Verdaguer R, Freites O. A steroid-cell tumor of the ovary resulting in massive androgen excess early in the gonadol steroidogenic pathway. Gynecol Endocrinol. 2008;24:502-4 pubmed publisher
    ..We review the literature and discuss the possible endocrine etiology of the excess androgens observed in this case. We also discuss the differential diagnosis, investigation and interpretation of androgens of adrenal and ovarian origin...
  20. Ehrmann D, Rosenfield R, Barnes R, Brigell D, Sheikh Z. Detection of functional ovarian hyperandrogenism in women with androgen excess. N Engl J Med. 1992;327:157-62 pubmed
    ..We determined the usefulness of testing with nafarelin to distinguish ovarian causes of hyperandrogenism in women...
  21. Cheung C, Ezzat S, Smyth H, Asa S. The spectrum and significance of primary hypophysitis. J Clin Endocrinol Metab. 2001;86:1048-53 pubmed
    ..Histological confirmation of the diagnosis of hypophysitis can be obtained by performing a biopsy or by requesting an intraoperative frozen section consultation...
  22. Guo M, Chen Z, Eijkemans M, Goverde A, Fauser B, Macklon N. Comparison of the phenotype of Chinese versus Dutch Caucasian women presenting with polycystic ovary syndrome and oligo/amenorrhoea. Hum Reprod. 2012;27:1481-8 pubmed publisher
    ..Polycystic ovary syndrome (PCOS) is a complex disorder with variable prevalence and clinical presentation in different populations, which may be mediated by geographical and ethnic background...
  23. Singer K, Rosenthal A, Kasa Vubu J. Elevated testosterone and hypergonadotropism in active adolescents of normal weight with oligomenorrhea. J Pediatr Adolesc Gynecol. 2009;22:323-7 pubmed publisher
    b>Oligomenorrhea in active adolescent females of normal weight is presumed to be related to hypoestrogenism secondary to physical activity and decreased fat mass...
  24. Fawole A, Babarinsa I, Fawole O, Obisesan K, Ojengbede O. Menstrual characteristics of secondary school girls in Ibadan, Nigeria. West Afr J Med. 2009;28:92-6 pubmed
    ..Disturbances of menstrual function are the commonest complaints among adolescents. Disorders of menstruation may have implications for future reproductive health...
  25. Awdishu S, Williams N, Laredo S, De Souza M. Oligomenorrhoea in exercising women: a polycystic ovarian syndrome phenotype or distinct entity?. Sports Med. 2009;39:1055-69 pubmed publisher
    ..Further investigation is necessary to explore whether different endocrine aetiologies underly menstrual disturbances, particularly oligomenorrhoea, in physically active women...
  26. Suliman A, Smith T, Gibney J, McKenna T. Frequent misdiagnosis and mismanagement of hyperprolactinemic patients before the introduction of macroprolactin screening: application of a new strict laboratory definition of macroprolactinemia. Clin Chem. 2003;49:1504-9 pubmed
    ..We applied normative data for serum prolactin after treatment of sera to remove macroprolactin to elucidate the contribution of macroprolactin to misleading diagnoses, inappropriate investigations, and unnecessary treatment...
  27. To W, Wong M. Comparison of quality of life scores among non-exercising adolescent females and adolescent dancers with oligomenorrhea and amenorrhea. J Pediatr Adolesc Gynecol. 2007;20:83-8 pubmed
    To evaluate whether oligomenorrhea and amenorrhea in adolescent females would have a negative effect on the standard quality of life (QOL) scores as compared to eumenorrheic adolescents, and whether such scoring would differ between those ..
  28. Formuso C, Stracquadanio M, Ciotta L. Myo-inositol vs. D-chiro inositol in PCOS treatment. Minerva Ginecol. 2015;67:321-5 pubmed
    ..the clinical, endocrine and metabolic response after 6 months of therapy in 137 PCOS women characterized by oligomenorrhea and/or acne and/or mild hirsutism and insulin-resistance...
  29. Rosa e Silva A, Rosa e Silva J, Reis R, Tone L, Silva de Sá M, Ferriani R. Gonadal function in adolescent patients submitted to chemotherapy during childhood or during the pubertal period. J Pediatr Adolesc Gynecol. 2007;20:89-91 pubmed
    ..To determine the presence of impaired gonadal function in adolescent patients submitted to chemotherapy during childhood or during the pubertal period...
  30. Brower M, Brennan K, Pall M, Azziz R. The severity of menstrual dysfunction as a predictor of insulin resistance in PCOS. J Clin Endocrinol Metab. 2013;98:E1967-71 pubmed publisher
    ..The objective of the study was to evaluate the relationship between the severity of menstrual disturbances and the degree of insulin resistance in women with polycystic ovary syndrome (PCOS)...
  31. Urbanek M, Legro R, Driscoll D, Azziz R, Ehrmann D, Norman R, et al. Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. Proc Natl Acad Sci U S A. 1999;96:8573-8 pubmed
    ..Our study shows how a systematic screen of candidate genes can provide strong evidence for genetic linkage in complex diseases and can identify those genes that should have high (or low) priority for further study...
  32. Glueck C, Morrison J, Daniels S, Wang P, Stroop D. Sex hormone-binding globulin, oligomenorrhea, polycystic ovary syndrome, and childhood insulin at age 14 years predict metabolic syndrome and class III obesity at age 24 years. J Pediatr. 2011;159:308-13.e2 pubmed publisher
    We hypothesized that oligomenorrhea (menstrual cyclicity ?42 days), hyperandrogenism, low levels of sex hormone-binding globulin (SHBG), childhood insulin, and metabolic syndrome (MetS) at age 14 years would predict MetS and class III ..
  33. Yong E, Glasier A, Hillier H, Ledger W, Caird L, Beattie G, et al. Effect of cyclofenil on hormonal dynamics, follicular development and cervical mucus in normal and oligomenorrhoeic women. Hum Reprod. 1992;7:39-43 pubmed
    ..In view of our inability to demonstrate an effect on any parameter of endocrine function in normal and oligomenorrhoeic women, these results throw doubt on the therapeutic value of cyclofenil in its present dosage and formulation...
  34. Luque Ramírez M, Alvarez Blasco F, Botella Carretero J, Sanchón R, San Millan J, Escobar Morreale H. Increased body iron stores of obese women with polycystic ovary syndrome are a consequence of insulin resistance and hyperinsulinism and are not a result of reduced menstrual losses. Diabetes Care. 2007;30:2309-13 pubmed
  35. Bilian X. Intrauterine devices. Best Pract Res Clin Obstet Gynaecol. 2002;16:155-68 pubmed
    ..The copper IUD is the most effective method for emergency contraception. It can prevent over 95% of unwanted pregnancies within 5 days of unprotected intercourse...
  36. Muñoz M, de la Piedra C, Barrios V, Garrido G, Argente J. Changes in bone density and bone markers in rhythmic gymnasts and ballet dancers: implications for puberty and leptin levels. Eur J Endocrinol. 2004;151:491-6 pubmed
    ..Our aim was to compare physical activity and biochemical markers with bone mineral acquisition in rhythmic gymnasts and ballet dancers...
  37. Wiksten Almströmer M, Hirschberg A, Hagenfeldt K. Reduced bone mineral density in adult women diagnosed with menstrual disorders during adolescence. Acta Obstet Gynecol Scand. 2009;88:543-9 pubmed publisher
    ..To evaluate the long-term effects on bone mineral density (BMD) in women diagnosed with menstrual disorders in their adolescence...
  38. Csermely T, Halvax L, Schmidt E, Zambo K, Vadon G, Szabo I, et al. Occurrence of osteopenia among adolescent girls with oligo/amenorrhea. Gynecol Endocrinol. 2002;16:99-105 pubmed
    The occurrence of reduced bone mineral density (BMD) among adolescent girls with oligomenorrhea or secondary amenorrhea, due to 'pure' dysfunction of the hypothalamo-pituitary-ovarian (HPO) axis (without anorexia nervosa, excessive sport ..
  39. Kumarapeli V, Seneviratne R, Wijeyaratne C, Yapa R, Dodampahala S. A simple screening approach for assessing community prevalence and phenotype of polycystic ovary syndrome in a semi-urban population in Sri Lanka. Am J Epidemiol. 2008;168:321-8 pubmed publisher
    ..The most common phenotypes of PCOS were oligo/amenorrhea and polycystic ovaries (91.4%) and oligo/amenorrhea and hirsutism (48.3%)...
  40. Oh J, Sung Y, Lee H. Clinical implications of menstrual cycle length in oligomenorrhoeic young women. Clin Endocrinol (Oxf). 2014;80:115-21 pubmed publisher
    ..We evaluated whether a longer menstrual cycle length is associated with less favourable metabolic features...
  41. Cho S, Damokosh A, Ryan L, Chen D, Hu Y, Smith T, et al. Effects of exposure to organic solvents on menstrual cycle length. J Occup Environ Med. 2001;43:567-75 pubmed
    ..logistic regression to estimate odds ratios and 95% confidence intervals for prolonged menstrual cycle length (oligomenorrhea: average cycle length > 35 days during the previous year) associated with the exposure...
  42. Lewandowski K, Cajdler Łuba A, Salata I, Bienkiewicz M, Lewinski A. The utility of the gonadotrophin releasing hormone (GnRH) test in the diagnosis of polycystic ovary syndrome (PCOS). Endokrynol Pol. 2011;62:120-8 pubmed
    ..As GnRH stimulation can reveal a relative LH excess, we have endeavoured to assess whether GnRH test might be useful in the diagnosis of PCOS...
  43. Cardigno P. Homeopathy for the treatment of menstrual irregularities: a case series. Homeopathy. 2009;98:97-106 pubmed publisher
    ..18 consecutive cases of secondary amenorrhea (SA) and oligomenorrhea (OL) met the entry criteria. 8 women had SA, 2 were on HRT, 6 had OL-AM and 2 had OL...
  44. Castelo Branco C, Vicente J, Pons F, Martinez de Osaba M, Casals E, Vanrell J. Bone mineral density in young, hypothalamic oligoamenorrheic women treated with oral contraceptives. J Reprod Med. 2001;46:875-9 pubmed
    ..To evaluate whether decreasing doses of ethinyl estradiol affect bone loss related to hypothalamic amenorrhea...
  45. Fothergill D. Common menstrual problems in adolescence. Arch Dis Child Educ Pract Ed. 2010;95:199-203 pubmed publisher
    ..This article focuses on a practical approach to managing menorrhagia, dysmenorrhoea, oligomenorrhoea and premenstrual syndrome (PMS) and reviews the literature on this topic...
  46. Helge E, Kanstrup I. Bone density in female elite gymnasts: impact of muscle strength and sex hormones. Med Sci Sports Exerc. 2002;34:174-80 pubmed
    ..The aim of this study was to investigate BMD in Danish female elite gymnasts and the relationships to maximal muscle strength, sex hormone concentrations, and menstrual status...
  47. Nidhi R, Padmalatha V, Nagarathna R, Amritanshu R. Prevalence of polycystic ovarian syndrome in Indian adolescents. J Pediatr Adolesc Gynecol. 2011;24:223-7 pubmed publisher
    ..PCOS is a common female endocrine disorder with prevalence ranging from 2.2% to 26%. Most reports have studied adult women with age ranged from 18 to 45 years. The aim of this study was to find the prevalence of PCOS in Indian adolescents...
  48. Imani B, Eijkemans M, te Velde E, Habbema J, Fauser B. A nomogram to predict the probability of live birth after clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility. Fertil Steril. 2002;77:91-7 pubmed
    ..To establish whether initial screening characteristics of normogonadotropic anovulatory infertile women can aid in predicting live birth after induction of ovulation with clomiphene citrate (CC)...
  49. Bhattacharya S, Jha A. A comparison of health-related quality of life (HRQOL) after natural and surgical menopause. Maturitas. 2010;66:431-4 pubmed publisher
    ..To compare the health-related quality of life (HRQOL) of women at surgical menopause with that of women at natural menopause, utilizing the Menopause Rating Scale (MRS-II)...
  50. Turhan N, Toppare M, Seckin N, Dilmen G. The predictive power of endocrine tests for the diagnosis of polycystic ovaries in women with oligoamenorrhea. Gynecol Obstet Invest. 1999;48:183-6 pubmed
    ..By combining these two variables a higher area under curve was obtained. LH/FSH ratio, insulin or the combination of these two can predict the disease probability in women with PCOS...
  51. Oktem M, Ozcimen E, Uckuyu A, Esinler I, Pamuk B, Bayraktar N, et al. Polycystic ovary syndrome is associated with elevated plasma soluble CD40 ligand, a marker of coronary artery disease. Fertil Steril. 2009;91:2545-50 pubmed publisher
    ..To determine the level of plasma soluble CD40 ligand (sCD40L) in patients with polycystic ovary syndrome (PCOS)...
  52. Panay N, Pritsch M, Alt J. Cyclical dydrogesterone in secondary amenorrhea: results of a double-blind, placebo-controlled, randomized study. Gynecol Endocrinol. 2007;23:611-8 pubmed
    ..of dydrogesterone in inducing regular withdrawal bleeds in premenopausal women with secondary amenorrhea or oligomenorrhea and normal estrogen levels, a double-blind, randomized, placebo-controlled, multicenter study was conducted in ..
  53. Bhattacharya S. Hyperandrogenism in oligomenorrhoea with minimal or nil 'unwanted hair growth'. Gynecol Endocrinol. 2009;25:423-6 pubmed publisher
    ..To detect whether oligomenorrhoea with minimal or nil 'unwanted hair growth' is a hyperandrogenic problem...