amenorrhea

Summary

Summary: Absence of menstruation.

Top Publications

  1. Swain S, Jeong J, Wolmark N. Amenorrhea from breast cancer therapy--not a matter of dose. N Engl J Med. 2010;363:2268-70 pubmed publisher
  2. Abbate Daga G, Campisi S, Marzola E, Rocca G, Peris C, Campagnoli C, et al. Amenorrhea in eating disorders: poor stability of symptom after a one-year treatment. Eat Weight Disord. 2012;17:e78-85 pubmed
    ..To examine whether patients with Eating Disorders (ED) who restore menses differ from those who remain amenorrheic after treatment and to provide longitudinal data about this debated criterion of Anorexia Nervosa (AN)...
  3. Rosendahl M, Ahlgren J, Andersen J, Bergh J, Blomquist C, Lidbrink E, et al. The risk of amenorrhoea after adjuvant chemotherapy for early stage breast cancer is related to inter-individual variations in chemotherapy-induced leukocyte nadir in young patients: data from the randomised SBG 2000-1 study. Eur J Cancer. 2009;45:3198-204 pubmed publisher
    ..Amenorrhoea is a common side-effect to chemotherapy of premenopausal women. We examine the association between chemotherapy-induced leucopaenia and the development of amenorrhoea in premenopausal women with breast cancer...
  4. Pérez Fidalgo J, Rosello S, García Garré E, Jordá E, Martín Martorell P, Bermejo B, et al. Incidence of chemotherapy-induced amenorrhea in hormone-sensitive breast cancer patients: the impact of addition of taxanes to anthracycline-based regimens. Breast Cancer Res Treat. 2010;120:245-51 pubmed publisher
    ..The incidence of chemotherapy-induced amenorrhea (CIA) varies depending on the patients' age, dose and the type of chemotherapy that they receive...
  5. Abusief M, Missmer S, Ginsburg E, Weeks J, Partridge A. The effects of paclitaxel, dose density, and trastuzumab on treatment-related amenorrhea in premenopausal women with breast cancer. Cancer. 2010;116:791-8 pubmed publisher
    ..Little information is available regarding the effects of new adjuvant treatment regimens on menstrual functioning in premenopausal women with early breast cancer...
  6. Mantzoros C, Magkos F, Brinkoetter M, Sienkiewicz E, Dardeno T, Kim S, et al. Leptin in human physiology and pathophysiology. Am J Physiol Endocrinol Metab. 2011;301:E567-84 pubmed publisher
    ..deficiency (subjects with lipoatrophy, congenital or related to HIV infection, and women with hypothalamic amenorrhea) reverses the energy homeostasis and neuroendocrine and metabolic abnormalities associated with these conditions...
  7. Su H, Sammel M, Green J, Velders L, Stankiewicz C, Matro J, et al. Antimullerian hormone and inhibin B are hormone measures of ovarian function in late reproductive-aged breast cancer survivors. Cancer. 2010;116:592-9 pubmed publisher
  8. Russell M, Misra M. Influence of ghrelin and adipocytokines on bone mineral density in adolescent female athletes with amenorrhea and eumenorrheic athletes. Med Sport Sci. 2010;55:103-13 pubmed publisher
    ..energy availability to the hypothalamus and contribute to suppression of gonadotropin pulsatility, hypothalamic amenorrhea and consequent decreased BMD...
  9. Bentov Y, Kenigsberg S, Casper R. A novel luteinizing hormone/chorionic gonadotropin receptor mutation associated with amenorrhea, low oocyte yield, and recurrent pregnancy loss. Fertil Steril. 2012;97:1165-8 pubmed publisher
    To study the cause for poor oocyte yield, amenorrhea, and recurrent pregnancy loss in a patient undergoing IVF.

Scientific Experts

More Information

Publications62

  1. Gordon C. Clinical practice. Functional hypothalamic amenorrhea. N Engl J Med. 2010;363:365-71 pubmed publisher
  2. Wu R, Jin H, Gao K, Twamley E, Ou J, Shao P, et al. Metformin for treatment of antipsychotic-induced amenorrhea and weight gain in women with first-episode schizophrenia: a double-blind, randomized, placebo-controlled study. Am J Psychiatry. 2012;169:813-21 pubmed publisher
    Data on the treatment of antipsychotic-induced amenorrhea, particularly when occurring with weight gain, are limited...
  3. Shaaban O, Hassen S, Nour S, Kames M, Yones E. Emergency contraceptive pills as a backup for lactational amenorrhea method (LAM) of contraception: a randomized controlled trial. Contraception. 2013;87:363-9 pubmed publisher
    ..quot; This is due to unexpected expiration of one or more of the lactation amenorrhea method (LAM) prerequisites...
  4. Jung M, Shin H, Rha S, Jeung H, Hong S, Moon Y, et al. The clinical outcome of chemotherapy-induced amenorrhea in premenopausal young patients with breast cancer with long-term follow-up. Ann Surg Oncol. 2010;17:3259-68 pubmed publisher
    We investigated the factors that predict chemotherapy-induced amenorrhea (CIA) and the prognostic significance of CIA after long-term follow-up.
  5. Najafi S, Djavid G, Mehrdad N, Rajaii E, Alavi N, Olfatbakhsh A, et al. Taxane-based regimens as a risk factor for chemotherapy-induced amenorrhea. Menopause. 2011;18:208-12 pubmed publisher
    The objective of our study was to show the impact of different chemotherapy regimens on the incidence of amenorrhea (chemotherapy-induced amenorrhea [CIA]) in premenopausal women of various ages with breast cancer.
  6. Arimura C, Nozaki T, Takakura S, Kawai K, Takii M, Sudo N, et al. Predictors of menstrual resumption by patients with anorexia nervosa. Eat Weight Disord. 2010;15:e226-33 pubmed publisher
    ..To investigate which factors predict the resumption of menstruation by patients with anorexia nervosa (AN)...
  7. Sehested L, Møller R, Bache I, Andersen N, Ullmann R, Tommerup N, et al. Deletion of 7q34-q36.2 in two siblings with mental retardation, language delay, primary amenorrhea, and dysmorphic features. Am J Med Genet A. 2010;152A:3115-9 pubmed publisher
    ..The sister had primary amenorrhea. Array CGH revealed a 12.2?Mb deletion at 7q34-q36...
  8. Ortmann O, Pagani O, Jones A, Maass N, Noss D, Rugo H, et al. Which factors should be taken into account in perimenopausal women with early breast cancer who may become eligible for an aromatase inhibitor? Recommendations of an expert panel. Cancer Treat Rev. 2011;37:97-104 pubmed publisher
  9. Seeman M. Antipsychotic-induced amenorrhea. J Ment Health. 2011;20:484-91 pubmed publisher
    Many antipsychotic drugs used to treat schizophrenia can cause amenorrhea in a significant proportion of women. The overall impact of this side effect has been little studied.
  10. Attia E, Roberto C. Should amenorrhea be a diagnostic criterion for anorexia nervosa?. Int J Eat Disord. 2009;42:581-9 pubmed publisher
    The removal of the amenorrhea criterion for anorexia nervosa (AN) is being considered for the fifth edition of The Diagnostic and Statistical Manual (DSM-V)...
  11. Santoro N. Update in hyper- and hypogonadotropic amenorrhea. J Clin Endocrinol Metab. 2011;96:3281-8 pubmed publisher
    b>Amenorrhea is a relatively common condition that is present in up to 5% of adult women at any time. The clinical significance of a lack of regular menstrual cycles extends beyond reproductive concerns...
  12. Torino F, Barnabei A, De Vecchis L, Appetecchia M, Strigari L, Corsello S. Recognizing menopause in women with amenorrhea induced by cytotoxic chemotherapy for endocrine-responsive early breast cancer. Endocr Relat Cancer. 2012;19:R21-33 pubmed publisher
    Cytotoxic anticancer treatment may induce amenorrhea or menopause to a variable extent...
  13. Anderson R, Cameron D. Pretreatment serum anti-müllerian hormone predicts long-term ovarian function and bone mass after chemotherapy for early breast cancer. J Clin Endocrinol Metab. 2011;96:1336-43 pubmed publisher
    ..However, age is the only patient characteristic currently recognized to be predictive of long-term ovarian function after chemotherapy...
  14. Jayasena C, Nijher G, Abbara A, Murphy K, Lim A, Patel D, et al. Twice-weekly administration of kisspeptin-54 for 8 weeks stimulates release of reproductive hormones in women with hypothalamic amenorrhea. Clin Pharmacol Ther. 2010;88:840-7 pubmed publisher
    ..KP-54) injection acutely stimulates the release of reproductive hormones in women with hypothalamic amenorrhea (HA), a commonly occurring condition characterized by absence of menstruation; however, twice-daily ..
  15. Weissheimer K, Herod S, Cameron J, Bethea C. Interactions of corticotropin-releasing factor, urocortin and citalopram in a primate model of stress-induced amenorrhea. Neuroendocrinology. 2010;92:224-34 pubmed publisher
    We established a cynomolgus macaque model of stress-induced amenorrhea in which the application of combined metabolic and psychosocial stress suppressed ovulation in stress-sensitive (SS) individuals, but not in highly stress-resilient (..
  16. Zhou W, Ding Q, Liang X, He Z, Zha X, Liu X, et al. The risk of amenorrhea is related to chemotherapy-induced leucopenia in breast cancer patients receiving epirubicin and taxane based chemotherapy. PLoS ONE. 2012;7:e37249 pubmed publisher
    Chemotherapy-induced amenorrhea (CIA) is common in young breast cancer patients. The incidence of CIA associated with regimens involving epirubicin and taxane was not well known...
  17. Ruddy K, O Neill A, Miller K, Schneider B, Baker E, Sparano J, et al. Biomarker prediction of chemotherapy-related amenorrhea in premenopausal women with breast cancer participating in E5103. Breast Cancer Res Treat. 2014;144:591-7 pubmed publisher
    ..to investigate whether pre-chemotherapy anti-mullerian hormone (AMH) is a biomarker for chemotherapy-related amenorrhea (CRA) in breast cancer patients...
  18. Deligeoroglou E, Athanasopoulos N, Tsimaris P, Dimopoulos K, Vrachnis N, Creatsas G. Evaluation and management of adolescent amenorrhea. Ann N Y Acad Sci. 2010;1205:23-32 pubmed publisher
    ..The complete absence or cessation of menses, which is defined as amenorrhea, requires careful evaluation and management...
  19. Kottler M, Chou Y, Chabre O, Richard N, Polge C, Brailly Tabard S, et al. A new FSHbeta mutation in a 29-year-old woman with primary amenorrhea and isolated FSH deficiency: functional characterization and ovarian response to human recombinant FSH. Eur J Endocrinol. 2010;162:633-41 pubmed publisher
    ..Mutations of the FSHbeta gene, causing in women isolated FSH deficiency and hypogonadism, are very rare and only a few have been described...
  20. Jayasena C, Nijher G, Chaudhri O, Murphy K, Ranger A, Lim A, et al. Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis. J Clin Endocrinol Metab. 2009;94:4315-23 pubmed publisher
    ..However, the effects of kisspeptin on gonadotropin release in women with hypothalamic amenorrhea (HA) and the effects of repeated administration of kisspeptin to humans are unknown...
  21. Sukumvanich P, Case L, Van Zee K, Singletary S, Paskett E, Petrek J, et al. Incidence and time course of bleeding after long-term amenorrhea after breast cancer treatment: a prospective study. Cancer. 2010;116:3102-11 pubmed publisher
    The incidence of chemotherapy-induced amenorrhea (CIA) and the time to subsequent menstrual bleeding in premenopausal breast cancer patients treated with current standard chemotherapy regimens was examined.
  22. Aronis K, Kilim H, Chamberland J, Breggia A, Rosen C, Mantzoros C. Preadipocyte factor-1 levels are higher in women with hypothalamic amenorrhea and are associated with bone mineral content and bone mineral density through a mechanism independent of leptin. J Clin Endocrinol Metab. 2011;96:E1634-9 pubmed publisher
    ..No previous studies exist on pref-1 in women with exercise-induced hypothalamic amenorrhea (HA), which similar to anorexia nervosa, is an energy-deficiency state associated with hypoleptinemia.
  23. Mou J, Tang P, Chan K, Tam Y, Lee K. Imperforate hymen: cause of lower abdominal pain in teenage girls. Singapore Med J. 2009;50:e378-9 pubmed
    ..We report an imperforate hymen presenting as abdominal pain in three teenage girls aged 12, 12 and 13 years, respectively, within a six-month period. The presentation was reviewed and the various types of hymenotomy were discussed...
  24. Sowinska Przepiera E, Chełstowski K, Friebe Z, Syrenicz A. Bone mineral density in girls with functional hypothalamic amenorrhea subjected to estroprogestagen treatment--a 4-year prospective study. Gynecol Endocrinol. 2011;27:966-70 pubmed publisher
    ..therapy (EP) on the bone mineral density (BMD) of 16- to 17-year-old girls with functional hypothalamic amenorrhea (FHA, n = 78)...
  25. Safai A, Vasei M, Attaranzadeh A, Azad F, Tabibi N. Chromosomal abnormality in patients with secondary amenorrhea. Arch Iran Med. 2012;15:232-4 pubmed publisher
    Secondary amenorrhea is a condition in which there is cessation of menses after at least one menstruation...
  26. Adachi T, Sato H, Nakayama S, Shimizu S, Matsui H, Nakabayashi M. Primary amenorrhea due to juvenile granulosa-cell tumor of the ovary: a case report. J Obstet Gynaecol Res. 2012;38:597-600 pubmed publisher
    In general, primary amenorrhea is caused by gonadal dysgenesis, anomalies of internal or external genitalia with or without chromosomal anomalies, and sometimes by hormonal abnormalities that affect the hypothalamus, pituitary, ovaries, ..
  27. Philibert P, Leprieur E, Zenaty D, Thibaud E, Polak M, Frances A, et al. Steroidogenic factor-1 (SF-1) gene mutation as a frequent cause of primary amenorrhea in 46,XY female adolescents with low testosterone concentration. Reprod Biol Endocrinol. 2010;8:28 pubmed publisher
    Primary amenorrhea due to 46,XY disorders of sex differentiation (DSD) is a frequent reason for consultation in endocrine and gynecology clinics...
  28. Costa M, Krupa F, Rehder P, Sousa M, Costa Paiva L, Cecatti J. Forearm bone mineral density changes during postpartum and the effects of breastfeeding, amenorrhea, body mass index and contraceptive use. Osteoporos Int. 2012;23:1691-8 pubmed publisher
    ..up to 12 months postpartum of healthy women and its association with breastfeeding, contraceptive methods, amenorrhea, and body mass index (BMI)...
  29. Chou S, Chamberland J, Liu X, Matarese G, Gao C, Stefanakis R, et al. Leptin is an effective treatment for hypothalamic amenorrhea. Proc Natl Acad Sci U S A. 2011;108:6585-90 pubmed publisher
    Hypothalamic amenorrhea (HA) is associated with dysfunction of the hypothalamic-pituitary-peripheral endocrine axes, leading to infertility and bone loss, and usually is caused by chronic energy deficiency secondary to strenuous exercise ..
  30. Okanami Y, Ito Y, Watanabe C, Iijima K, Iwase T, Tokudome N, et al. Incidence of chemotherapy-induced amenorrhea in premenopausal patients with breast cancer following adjuvant anthracycline and taxane. Breast Cancer. 2011;18:182-8 pubmed publisher
    The purpose of this study was to determine the incidence of amenorrhea among breast cancer patients aged 40 years and younger following adjuvant chemotherapy.
  31. Caronia L, Martin C, Welt C, Sykiotis G, Quinton R, Thambundit A, et al. A genetic basis for functional hypothalamic amenorrhea. N Engl J Med. 2011;364:215-25 pubmed publisher
    Functional hypothalamic amenorrhea is a reversible form of gonadotropin-releasing hormone (GnRH) deficiency commonly triggered by stressors such as excessive exercise, nutritional deficits, or psychological distress...
  32. Tanmahasamut P, Rattanachaiyanont M, Dangrat C, Indhavivadhana S, Angsuwattana S, Techatraisak K. Causes of primary amenorrhea: a report of 295 cases in Thailand. J Obstet Gynaecol Res. 2012;38:297-301 pubmed publisher
    The aim of this study was to determine the prevalence of etiologic causes of primary amenorrhea in Thailand.
  33. Myers E, Hurst B. Comprehensive management of severe Asherman syndrome and amenorrhea. Fertil Steril. 2012;97:160-4 pubmed publisher
    To describe a comprehensive approach to women with severe Asherman syndrome and amenorrhea, including preoperative, operative, and postoperative care and subsequent resumption menses, and pregnancy.
  34. Genazzani A, Chierchia E, Santagni S, Rattighieri E, Farinetti A, Lanzoni C. Hypothalamic amenorrhea: from diagnosis to therapeutical approach. Ann Endocrinol (Paris). 2010;71:163-9 pubmed publisher
    Among secondary amenorrheas, hypothalamic amenorrhea (HA) is the one with no evidence of endocrine/systemic causal factors. HA is mainly related to various stressors affecting neuroendocrine control of the reproductive axis...
  35. Swain S, Jeong J, Geyer C, Costantino J, Pajon E, Fehrenbacher L, et al. Longer therapy, iatrogenic amenorrhea, and survival in early breast cancer. N Engl J Med. 2010;362:2053-65 pubmed publisher
    ..The effectiveness of concurrent versus sequential regimens is not known...
  36. Conroy S, McDonald B, Ahles T, West J, Saykin A. Chemotherapy-induced amenorrhea: a prospective study of brain activation changes and neurocognitive correlates. Brain Imaging Behav. 2013;7:491-500 pubmed publisher
    Chemotherapy-induced amenorrhea (CIA) often occurs in pre- and peri-menopausal BC patients, and while cancer/chemotherapy and abrupt estrogen loss have separately been shown to affect cognition and brain function, studies of the cognitive ..
  37. Podfigurna Stopa A, Casarosa E, Luisi M, Czyzyk A, Meczekalski B, Genazzani A. Decreased plasma concentrations of brain-derived neurotrophic factor (BDNF) in patients with functional hypothalamic amenorrhea. Gynecol Endocrinol. 2013;29:817-20 pubmed publisher
    Functional hypothalamic amenorrhea (FHA) is a non organic, secondary amenorrhea related to gonadotropin-releasing hormone pulsatile secretion impairment...
  38. Zhou W, Yin H, Liu X, Zha X, Chen L, Dai J, et al. Incidence of chemotherapy-induced amenorrhea associated with epirubicin, docetaxel and navelbine in younger breast cancer patients. BMC Cancer. 2010;10:281 pubmed publisher
    The rates of chemotherapy-induced amenorrhea (CIA) associated with docetaxel-based regimens reported by previous studies are discordant. For navelbine-based chemotherapies, rates of CIA have seldom been reported.
  39. Lawson E, Donoho D, Miller K, Misra M, Meenaghan E, Lydecker J, et al. Hypercortisolemia is associated with severity of bone loss and depression in hypothalamic amenorrhea and anorexia nervosa. J Clin Endocrinol Metab. 2009;94:4710-6 pubmed publisher
    Anorexia nervosa (AN) and functional hypothalamic amenorrhea (HA) are associated with low bone density, anxiety, and depression. Women with AN and HA have elevated cortisol levels...
  40. Kelesidis T, Kelesidis I, Chou S, Mantzoros C. Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med. 2010;152:93-100 pubmed publisher
    ..Leptin deficiency is also evident in patients with diet- or exercise-induced hypothalamic amenorrhea and lipoatrophy...
  41. Achrekar S, Modi D, Meherji P, Patel Z, Mahale S. Follicle stimulating hormone receptor gene variants in women with primary and secondary amenorrhea. J Assist Reprod Genet. 2010;27:317-26 pubmed publisher
    This retrospective study was designed to analyze the FSHR gene variants in subjects with primary and secondary amenorrhea with hypergonadotropic hypogonadism.
  42. Silva C, Deen M, Febronio M, Oliveira S, Terreri M, Sacchetti S, et al. Hormone profile in juvenile systemic lupus erythematosus with previous or current amenorrhea. Rheumatol Int. 2011;31:1037-43 pubmed publisher
    To identify the underlying mechanism of amenorrhea in juvenile systemic lupus erythematosus (JSLE) patients, thirty-five (11...
  43. Laskari K, Zintzaras E, Tzioufas A. Ovarian function is preserved in women with severe systemic lupus erythematosus after a 6-month course of cyclophosphamide followed by mycophenolate mofetil. Clin Exp Rheumatol. 2010;28:83-6 pubmed
    ..To evaluate whether a short duration treatment with cyclophosphamide (CYC) followed by mycophenolate mofetil (MMF) is associated with preservation of the ovarian function in female patients with systemic lupus erythematosus (SLE)...
  44. Jedel E, Labrie F, Oden A, Holm G, Nilsson L, Janson P, et al. Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial. Am J Physiol Endocrinol Metab. 2011;300:E37-45 pubmed publisher
    ..the most common endocrine disorder in women of reproductive age, is characterized by hyperandrogenism, oligo/amenorrhea, and polycystic ovaries...
  45. Maimoun L, Philibert P, Bouchard P, Ocal G, LeHeup B, Fenichel P, et al. Primary amenorrhea in four adolescents revealed 5?-reductase deficiency confirmed by molecular analysis. Fertil Steril. 2011;95:804.e1-5 pubmed publisher
    To determine the genetic cause of primary amenorrhea.
  46. Warren M, Miller K, Olson W, Grinspoon S, Friedman A. Effects of an oral contraceptive (norgestimate/ethinyl estradiol) on bone mineral density in women with hypothalamic amenorrhea and osteopenia: an open-label extension of a double-blind, placebo-controlled study. Contraception. 2005;72:206-11 pubmed
    The effects of long-term triphasic oral contraceptive administration on bone mineral density (BMD) were investigated in premenopausal women with hypothalamic amenorrhea (HA) and osteopenia.
  47. Liu J, Bill A. Stress-associated or functional hypothalamic amenorrhea in the adolescent. Ann N Y Acad Sci. 2008;1135:179-84 pubmed publisher
    Stress-associated amenorrhea in the adolescent is likely similar to the disorder found in young reproductive-aged adults and is termed hypothalamic amenorrhea...
  48. Goyal N, Gore M, Shankar R. Galactorrhea and amenorrhea in burn patients. Burns. 2008;34:825-8 pubmed publisher
    Galactorrhea and/or amenorrhea, although uncommonly reported in post-burn patients, is a complex problem to treat. Patient is reluctant to volunteer history of these symptoms, unless asked specifically.
  49. Vescovi J, Jamal S, De Souza M. Strategies to reverse bone loss in women with functional hypothalamic amenorrhea: a systematic review of the literature. Osteoporos Int. 2008;19:465-78 pubmed publisher
    Functional hypothalamic amenorrhea (FHA) impairs the attainment of peak bone mass and as such can increase the risk of fractures later in life. To document available treatment strategies, we conducted a systematic review of the literature...
  50. Csermely T, Halvax L, Vizer M, Drozgyik I, Tamas P, Gocze P, et al. Relationship between adolescent amenorrhea and climacteric osteoporosis. Maturitas. 2007;56:368-74 pubmed
    ..The relationship between climacteric osteoporosis and disturbances in menstrual cycle during adolescence was examined...
  51. Marrakchi A, Belhaj L, Boussouf H, Chraibi A, Kadiri A. [Pure gonadal dysgenesis XX and XY: observations in fifteen patients]. Ann Endocrinol (Paris). 2005;66:553-6 pubmed
    ..Pure gondal dysgenesis is characterized by impuberism with a female phenotype without genital ambiguity. The aim of the study is to describe the diagnostic and therapeutic patterns as well as the clinical features...
  52. Chotnopparatpattara P, Taneepanichskul S, Treratanachat S, Charuruks N. Relationship between progesterone receptor level in endometrium and bleeding pattern in depot medroxyprogesterone acetate users. J Med Assoc Thai. 2003;86:172-7 pubmed
    ..Forty-five matched pairs of age and body mass index in DMPA users with bleeding and amenorrhea were studied. The endometrial PR levels were evaluated. The PR score was assessed semi-quantitatively...
  53. Jabbar S. Frequency of primary amenorrhea due to chromosomal aberration. J Coll Physicians Surg Pak. 2004;14:329-32 pubmed
    To find out the frequency of primary amenorrhea due to chromosomal aberration and the different options available for management.