lymphocytosis

Summary

Summary: Excess of normal lymphocytes in the blood or in any effusion.

Top Publications

  1. Baseggio L, Traverse Glehen A, Petinataud F, Callet Bauchu E, Berger F, Ffrench M, et al. CD5 expression identifies a subset of splenic marginal zone lymphomas with higher lymphocytosis: a clinico-pathological, cytogenetic and molecular study of 24 cases. Haematologica. 2010;95:604-12 pubmed publisher
    ..Whether or not CD5-positive splenic marginal zone B-cell lymphoma constitutes a true subset obviously requires the study of more cases. ..
  2. Yilmaz A, Kaleagasi H, Dogu O, Kara E, Ozge A. Abnormal MRI in a patient with 'headache with neurological deficits and CSF lymphocytosis (HaNDL)'. Cephalalgia. 2010;30:615-9 pubmed publisher
    ..The headache was diagnosed as headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL) syndrome according to the criteria of the second edition of the International Classification of ..
  3. Scarfo L, Dagklis A, Scielzo C, Fazi C, Ghia P. CLL-like monoclonal B-cell lymphocytosis: are we all bound to have it?. Semin Cancer Biol. 2010;20:384-90 pubmed publisher
    CLL-like monoclonal B-cell lymphocytosis (MBL) shares a unique immunophenotype with chronic lymphocytic leukemia (CLL), and represents the vast majority of clonal B-cell expansions found in the peripheral blood of otherwise healthy ..
  4. Goldin L, Lanasa M, Slager S, Cerhan J, Vachon C, Strom S, et al. Common occurrence of monoclonal B-cell lymphocytosis among members of high-risk CLL families. Br J Haematol. 2010;151:152-8 pubmed publisher
    Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic haematological condition characterized by low absolute levels of B-cell clones with a surface immunophenotype similar to that of chronic lymphocytic leukaemia (CLL)...
  5. Crowther Swanepoel D, Corre T, Lloyd A, Gaidano G, Olver B, Bennett F, et al. Inherited genetic susceptibility to monoclonal B-cell lymphocytosis. Blood. 2010;116:5957-60 pubmed publisher
    Monoclonal B-cell lymphocytosis (MBL) is detectable in > 3% of the general population...
  6. Lanasa M, Allgood S, Slager S, Dave S, Love C, Marti G, et al. Immunophenotypic and gene expression analysis of monoclonal B-cell lymphocytosis shows biologic characteristics associated with good prognosis CLL. Leukemia. 2011;25:1459-66 pubmed publisher
    Monoclonal B-cell lymphocytosis (MBL) is a hematologic condition wherein small B-cell clones can be detected in the blood of asymptomatic individuals...
  7. del Giudice I, Pileri S, Rossi M, Sabattini E, Campidelli C, Starza I, et al. Histopathological and molecular features of persistent polyclonal B-cell lymphocytosis (PPBL) with progressive splenomegaly. Br J Haematol. 2009;144:726-31 pubmed publisher
    Five cases of persistent polyclonal B-cell lymphocytosis (PPBL) with progressive splenomegaly are reported; three were splenectomized. BCL2/IGH rearrangements were found in three cases; HLA-DRB1*07 in all...
  8. Walker M, Talley N, Prabhakar M, Pennaneac h C, Aro P, Ronkainen J, et al. Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia. Aliment Pharmacol Ther. 2009;29:765-73 pubmed publisher
    ..001), while eosinophils were significantly increased in FD in D1 and D2 (P < 0.001). Duodenal mast cell hyperplasia is linked to IBS and eosinophilia to FD, and duodenal biopsy may identify subsets of these disorders. ..
  9. Sprague W, TerWee J, Vandewoude S. Temporal association of large granular lymphocytosis, neutropenia, proviral load, and FasL mRNA in cats with acute feline immunodeficiency virus infection. Vet Immunol Immunopathol. 2010;134:115-21 pubmed publisher
    ..virus-C(PGammar) (FIV-C-PG) infection, we observed that cats develop large granular lymphocyte (LGL) lymphocytosis concurrent with a marked neutropenia that is temporally associated with the rise and fall of FIV-C-PG proviral ..

More Information

Publications76

  1. Rossi D, Sozzi E, Puma A, De Paoli L, Rasi S, Spina V, et al. The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors. Br J Haematol. 2009;146:64-75 pubmed publisher
    Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic monoclonal expansion of <5.0 x 10(9)/l circulating CLL-phenotype B-cells...
  2. Pettersen J, Aviv R, Black S, Fox A, Lim A, Murray B. Global hemispheric CT hypoperfusion may differentiate headache with associated neurological deficits and lymphocytosis from acute stroke. Stroke. 2008;39:492-3 pubmed publisher
  3. Nieto W, Almeida J, Romero A, Teodosio C, Lopez A, Henriques A, et al. Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B-cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach. Blood. 2009;114:33-7 pubmed publisher
    Monoclonal B-cell lymphocytosis (MBL) indicates the presence of less than 5 x 10(9)/L circulating monoclonal B cells in otherwise healthy subjects...
  4. Juliarena M, Gutierrez S, Ceriani C. Determination of proviral load in bovine leukemia virus-infected cattle with and without lymphocytosis. Am J Vet Res. 2007;68:1220-5 pubmed
    To determine proviral load in bovine leukemia virus (BLV)-infected cattle with and without persistent lymphocytosis to assess the potential of transmitting the virus.
  5. Kakar S, Nehra V, Murray J, Dayharsh G, Burgart L. Significance of intraepithelial lymphocytosis in small bowel biopsy samples with normal mucosal architecture. Am J Gastroenterol. 2003;98:2027-33 pubmed
    ..Intraepithelial lymphocytosis in an otherwise normal small bowel biopsy is somewhat nonspecific, but in nearly 10% of cases can be the ..
  6. Basu D, Williams F, Ahn C, Reveille J. Changing spectrum of the diffuse infiltrative lymphocytosis syndrome. Arthritis Rheum. 2006;55:466-72 pubmed
    To describe the changing clinical spectrum of patients with diffuse infiltrative lymphocytosis syndrome (DILS) after the introduction of highly active antiretroviral treatment (HAART), and to carry out HLA class II oligotyping in these ..
  7. Birring S, Brightling C, Symon F, Barlow S, Wardlaw A, Pavord I. Idiopathic chronic cough: association with organ specific autoimmune disease and bronchoalveolar lymphocytosis. Thorax. 2003;58:1066-70 pubmed
    ..An immunopathological study was undertaken to test the hypothesis that idiopathic chronic cough is associated with lymphocytic airway inflammation...
  8. Hardy N, Grady C, Pentz R, Stetler Stevenson M, Raffeld M, Fontaine L, et al. Bioethical considerations of monoclonal B-cell lymphocytosis: donor transfer after haematopoietic stem cell transplantation. Br J Haematol. 2007;139:824-31 pubmed
    Monoclonal B-cell lymphocytosis (MBL) is a recently described laboratory finding in otherwise healthy individuals...
  9. Marti G, Abbasi F, Raveche E, Rawstron A, Ghia P, Aurran T, et al. Overview of monoclonal B-cell lymphocytosis. Br J Haematol. 2007;139:701-8 pubmed
    Monoclonal B-cell lymphocytosis (MBL) has been the subject of more intensive investigation for the last 10 years...
  10. Shim Y, Middleton D, Caporaso N, Rachel J, Landgren O, Abbasi F, et al. Prevalence of monoclonal B-cell lymphocytosis: a systematic review. Cytometry B Clin Cytom. 2010;78 Suppl 1:S10-8 pubmed publisher
    Individuals with monoclonal B-cell lymphocytosis (MBL) have been identified in clinic outpatients, in unaffected relatives of patients with chronic lymphocytic leukemia (CLL), and in general populations...
  11. Wolowiec D, Nowak J, Majewski M, Haus O, Duszenko E, Stella Holowiecka B, et al. High incidence of ancestral HLA haplotype 8.1 and monoclonal incomplete DH-JH immunoglobulin heavy chain gene rearrangement in persistent polyclonal B-cell lymphocytosis. Ann Hematol. 2008;87:597-8 pubmed publisher
  12. Akcam F, Aygun F, Akkaya V. DRESS like severe drug rash with eosinophilia, atypic lymphocytosis and fever secondary to ceftriaxone. J Infect. 2006;53:e51-3 pubmed
    ..Blood tests showed marked eosinophilia and atypic lymphocytosis. He was successfully treated with prednisone p.o...
  13. Lima M, Almeida J, Montero A, Teixeira M, Queirós M, Santos A, et al. Clinicobiological, immunophenotypic, and molecular characteristics of monoclonal CD56-/+dim chronic natural killer cell large granular lymphocytosis. Am J Pathol. 2004;165:1117-27 pubmed
    ..serological, and molecular features of a series of 26 patients with chronic large granular NK cell lymphocytosis, whose NK cells were either CD56(-) or expressed very low levels of CD56 (CD56(-/+dim) NK cells), in the ..
  14. Hauber H, Rüller S, Müller E, Hansen E, Zabel P. Pharyngeal lavage lymphocytosis in patients with obstructive sleep apnea: a preliminary observation. PLoS ONE. 2011;6:e16277 pubmed publisher
    ..Upper airway inflammation has been previously demonstrated in obstructive sleep apnea (OSA). However, investigation has been hampered by the necessity of invasive tissue biopsies...
  15. Fabris S, Mosca L, Cutrona G, Lionetti M, Agnelli L, Ciceri G, et al. Chromosome 2p gain in monoclonal B-cell lymphocytosis and in early stage chronic lymphocytic leukemia. Am J Hematol. 2013;88:24-31 pubmed publisher
    ..its relationship with common prognostic biomarkers in a prospective series of 69 clinical monoclonal B-cell lymphocytosis (cMBL) and 218 early stage (Binet A) CLL patients...
  16. Roh E, Chung E, Chang Y, Myoung N, Jee Y, Seo M, et al. A case of hypersensitivity to mosquito bite associated with Epstein-barr viral infection and natural killer cell lymphocytosis. J Korean Med Sci. 2010;25:321-3 pubmed publisher
    ..We describe here a Korean child who had HMB associated with chronic EBV infection and natural killer cell lymphocytosis. A 5-yr-old boy was suffered from necrotic skin lesions on the right ear lobe...
  17. Fazi C, Scarfo L, Pecciarini L, Cottini F, Dagklis A, Janus A, et al. General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL. Blood. 2011;118:6618-25 pubmed publisher
    Monoclonal B-cell lymphocytosis (MBL) is classified as chronic lymphocytic leukemia (CLL)-like, atypical CLL, and CD5(-) MBL...
  18. Schmidt Hieber M, Burmeister T, Weimann A, Nagorsen D, Hofmann W, Thiel E, et al. Combined automated cell and flow cytometric analysis enables recognition of persistent polyclonal B-cell lymphocytosis (PPBL), a study of 25 patients. Ann Hematol. 2008;87:829-36 pubmed publisher
    Persistent polyclonal B-cell lymphocytosis (PPBL) is an extremely rare disorder, which occurs almost exclusively in smoking women and is characterized by a lymphocytosis with circulating binucleated lymphocytes...
  19. Hauswirth A, Almeida J, Nieto W, Teodosio C, Rodriguez Caballero A, Romero A, et al. Monoclonal B-cell lymphocytosis (MBL) with normal lymphocyte counts is associated with decreased numbers of normal circulating B-cell subsets. Am J Hematol. 2012;87:721-4 pubmed publisher
    Monoclonal B-cell lymphocytosis (MBL) with normal lymphocyte counts is associated with decreased numbers of normal circulating B-cell subsets...
  20. Yagihara H, Uematsu Y, Koike A, Tamura K, Isotani M, Yamaguchi T, et al. Immunophenotyping and gene rearrangement analysis in dogs with lymphoproliferative disorders characterized by small-cell lymphocytosis. J Vet Diagn Invest. 2009;21:197-202 pubmed
    b>Lymphocytosis caused by neoplastic proliferation of small lymphocytes is occasionally difficult to distinguish by morphological examination from nonneoplastic lymphocytosis...
  21. Mori S, Mizoguchi A, Kawabata M, Fukunaga H, Usuku K, Maruyama I, et al. Bronchoalveolar lymphocytosis correlates with human T lymphotropic virus type I (HTLV-I) proviral DNA load in HTLV-I carriers. Thorax. 2005;60:138-43 pubmed
    ..A study was undertaken to investigate the pathogenesis of pulmonary involvement in human T lymphotropic virus type I (HTLV-I) carriers...
  22. Rawstron A, Bennett F, O Connor S, Kwok M, Fenton J, Plummer M, et al. Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. N Engl J Med. 2008;359:575-83 pubmed publisher
    ..Asymptomatic persons with fewer CLL-phenotype cells have monoclonal B-cell lymphocytosis (MBL). The goal of this study was to investigate the relation between MBL and CLL.
  23. Ondrejka S, Lai R, Smith S, Hsi E. Indolent mantle cell leukemia: a clinicopathological variant characterized by isolated lymphocytosis, interstitial bone marrow involvement, kappa light chain restriction, and good prognosis. Haematologica. 2011;96:1121-7 pubmed publisher
    ..We report a series of leukemic phase mantle cell lymphomas with a non-progressive or slowly progressive course...
  24. Parker E, MacDonald J, Wang C. Molecular characterization of a t(2;7) translocation linking CDK6 to the IGK locus in CD5(-) monoclonal B-cell lymphocytosis. Cancer Genet. 2011;204:260-4 pubmed publisher
    The term monoclonal B-cell lymphocytosis (MBL) is used to characterize individuals with a circulating population of clonal B-cells and no other features of a lymphoproliferative disorder...
  25. Shanafelt T, Kay N, Call T, Zent C, Jelinek D, Laplant B, et al. MBL or CLL: which classification best categorizes the clinical course of patients with an absolute lymphocyte count >or= 5 x 10(9) L(-1) but a B-cell lymphocyte count <5 x 10(9) L(-1)?. Leuk Res. 2008;32:1458-61 pubmed publisher
    To eliminate overlap with monoclonal B-cell lymphocytosis (MBL), some have proposed basing the diagnosis of chronic lymphocytic leukemia (CLL) on B lymphocyte count rather than absolute lymphocyte count (ALC)...
  26. Nahon S, Patey Mariaud de Serre N, Lejeune O, Huchet F, Lahmek P, Lesgourgues B, et al. Duodenal intraepithelial lymphocytosis during Helicobacter pylori infection is reduced by antibiotic treatment. Histopathology. 2006;48:417-23 pubmed
    ..To evaluate clinical, biological and immunological features of patients with increased duodenal intraepithelial lymphocytes (IELs), and its relation to Helicobacter pylori (HP) and coeliac disease (CD)...
  27. Fung S, Hillier K, Leger C, Sandhu I, Vickars L, Galbraith P, et al. Clinical progression and outcome of patients with monoclonal B-cell lymphocytosis. Leuk Lymphoma. 2007;48:1087-91 pubmed
    Monoclonal B-cell lymphocytosis (MBL) is a clonal lymphoproliferation with the immunophenotype of chronic lymphocytic leukemia (CLL) but a B-lymphocyte count of less than 5 x 10(9)/l and no lymphadenopathy, organomegaly, cytopenias or ..
  28. Snow A, Xiao W, Stinson J, Lu W, Chaigne Delalande B, Zheng L, et al. Congenital B cell lymphocytosis explained by novel germline CARD11 mutations. J Exp Med. 2012;209:2247-61 pubmed publisher
    ..whole transcriptome sequencing, we investigated a unique family with hereditary polyclonal B cell lymphocytosis. We found a novel germline heterozygous missense mutation (E127G) in affected patients in the gene encoding ..
  29. Vardi A, Dagklis A, Scarfo L, Jelinek D, Newton D, Bennett F, et al. Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL. Blood. 2013;121:4521-8 pubmed publisher
    Chronic lymphocytic leukemia (CLL) -like monoclonal B-cell lymphocytosis (MBL) shares common immunophenotype and cytogenetic abnormalities with CLL, from which it is discriminated by a cutoff value of 5 × 10(9)/L circulating clonal B ..
  30. Matos D, Ismael S, Scrideli C, de Oliveira F, Rego E, Falcão R. Monoclonal B-cell lymphocytosis in first-degree relatives of patients with sporadic (non-familial) chronic lymphocytic leukaemia. Br J Haematol. 2009;147:339-46 pubmed publisher
    Although biological similarities have been described among monoclonal B-cell lymphocytosis (MBL) and chronic lymphocytic leukaemia (CLL), the relationships between these two conditions are not fully understood, and new epidemiological ..
  31. Rossi S, Motta C, Studer V, Monteleone F, De Chiara V, Buttari F, et al. A genetic variant of the anti-apoptotic protein Akt predicts natalizumab-induced lymphocytosis and post-natalizumab multiple sclerosis reactivation. Mult Scler. 2013;19:59-68 pubmed publisher
    ..Multiple sclerosis (MS) patients discontinuing natalizumab treatment are at risk of disease reactivation. No clinical or surrogate parameters exist to identify patients at risk of post-natalizumab MS reactivation...
  32. Martinez Camacho A, Khaoustov V, Adam E, Lewis D, Tavakoli Tabasi S, Yoffe B. Lymphocytosis as a predictor of poor response to treatment of hepatitis C. Clin Res Hepatol Gastroenterol. 2011;35:34-40 pubmed publisher
    Identification of factors predicting response to therapy is critical in the management of hepatitis C. This study assessed significance of lymphocytosis as a predictor of sustained virological response (SVR).
  33. Morabito F, Mosca L, Cutrona G, Agnelli L, Tuana G, Ferracin M, et al. Clinical monoclonal B lymphocytosis versus Rai 0 chronic lymphocytic leukemia: A comparison of cellular, cytogenetic, molecular, and clinical features. Clin Cancer Res. 2013;19:5890-900 pubmed publisher
    ..and clinical relevance of classic and new prognostic markers, IGHV gene mutational status, and chromosomal abnormalities in clinical monoclonal B lymphocytosis (cMBL) compared with Rai stage 0 chronic lymphocytic leukemia (Rai0-CLL).
  34. Bishu S, Arsenescu V, Lee E, Vargas H, de Villiers W, Arsenescu R. Autoimmune enteropathy with a CD8+ CD7- T-cell small bowel intraepithelial lymphocytosis: case report and literature review. BMC Gastroenterol. 2011;11:131 pubmed publisher
    ..We present a unique case of AIE associated with a CD8+CD7- lymphocytosis and review the literature to characterize the histologic and immunologic abnormalities, and the autoantibodies ..
  35. Shim Y, Rachel J, Ghia P, Boren J, Abbasi F, Dagklis A, et al. Monoclonal B-cell lymphocytosis in healthy blood donors: an unexpectedly common finding. Blood. 2014;123:1319-26 pubmed publisher
    Circulating monoclonal B cells may be detected in healthy adults, a condition called monoclonal B-cell lymphocytosis (MBL). MBL has also been identified in donated blood, but no systematic study of blood donors has been reported...
  36. Asada H, Miyagawa S, Sumikawa Y, Yamaguchi Y, Itami S, Suguri S, et al. CD4+ T-lymphocyte-induced Epstein-Barr virus reactivation in a patient with severe hypersensitivity to mosquito bites and Epstein-Barr virus-infected NK cell lymphocytosis. Arch Dermatol. 2003;139:1601-7 pubmed
    Natural killer (NK) cell lymphocytosis associated with Epstein-Barr virus (EBV) infection often shows severe hypersensitivity to mosquito bites (HMB) characterized by intense local skin reactions and systemic symptoms such as high fever, ..
  37. Lee S, Ogilvie R, Dupre M, Gao Z. Intravascular lymphocytosis in acute appendicitis: potential mimicry of chronic lymphocytic leukaemia. Histopathology. 2009;55:660-4 pubmed publisher
    Intravascular lymphocytosis (IVL) in appendectomy specimens is a fairly common phenomenon but has not been described and studied in detail...
  38. Lanasa M, Allgood S, Volkheimer A, Gockerman J, Whitesides J, Goodman B, et al. Single-cell analysis reveals oligoclonality among 'low-count' monoclonal B-cell lymphocytosis. Leukemia. 2010;24:133-40 pubmed publisher
    Monoclonal B-cell lymphocytosis (MBL) is a preclinical hematologic syndrome characterized by small accumulations of CD5(+) B lymphocytes. Most MBL share phenotypic characteristics with chronic lymphocytic leukemia (CLL)...
  39. Aries M, van Oostrom J, de Keyser J. The syndrome of headache with neurologic deficits and cerebrospinal fluid lymphocytosis mimicking acute ischemic stroke. J Stroke Cerebrovasc Dis. 2008;17:246-7 pubmed publisher
    Headache with neurologic deficits and cerebrospinal fluid lymphocytosis is a benign condition with a transient ischemic attack-like presentation...
  40. Feugier P, De March A, Lesesve J, Monhoven N, Dorvaux V, Braun F, et al. Intravascular bone marrow accumulation in persistent polyclonal lymphocytosis: a misleading feature for B-cell neoplasm. Mod Pathol. 2004;17:1087-96 pubmed
    Persistent polyclonal B-cell lymphocytosis is usually reported in young smoking women. Whether this syndrome represents a premalignant or benign disease remains unclear...
  41. Lissoni P, Fumagalli L, Brivio F, Rovelli F, Messina G, Di Fede G, et al. Cancer chemotherapy-induced lymphocytosis: a revolutionary discovery in the medical oncology. J Biol Regul Homeost Agents. 2006;20:29-35 pubmed
    ..Independently of tumor histotype and chemotherapeutic regimen, a lymphocytosis occurred in patients who achieved an objective tumor regression in response to chemotherapy, and lymphocyte ..
  42. Garrido P, Ruiz Cabello F, Barcena P, Sandberg Y, Canton J, Lima M, et al. Monoclonal TCR-Vbeta13.1+/CD4+/NKa+/CD8-/+dim T-LGL lymphocytosis: evidence for an antigen-driven chronic T-cell stimulation origin. Blood. 2007;109:4890-8 pubmed
    Monoclonal TCRalphabeta(+)/CD4+ T-large granular lymphocyte (T-LGL) lymphocytosis is a T-cell disorder with a restricted TCR-Vbeta repertoire...
  43. Shim Y, Vogt R, Middleton D, Abbasi F, Slade B, Lee K, et al. Prevalence and natural history of monoclonal and polyclonal B-cell lymphocytosis in a residential adult population. Cytometry B Clin Cytom. 2007;72:344-53 pubmed
    ..the peripheral blood of some adults without B-cell malignancies, a condition recently termed monoclonal B-cell lymphocytosis (MBL). The risk of individuals with MBL progressing to a B-cell malignancy is unknown...
  44. Casabonne D, Almeida J, Nieto W, Romero A, Fernandez Navarro P, Rodriguez Caballero A, et al. Common infectious agents and monoclonal B-cell lymphocytosis: a cross-sectional epidemiological study among healthy adults. PLoS ONE. 2012;7:e52808 pubmed publisher
    Risk factors associated with monoclonal B-cell lymphocytosis (MBL), a potential precursor of chronic lymphocytic leukaemia (CLL), remain unknown.
  45. Costa E, Arroyo M, Pedreira C, Garcia Marcos M, Tabernero M, Almeida J, et al. A new automated flow cytometry data analysis approach for the diagnostic screening of neoplastic B-cell disorders in peripheral blood samples with absolute lymphocytosis. Leukemia. 2006;20:1221-30 pubmed
    ..cytometry immunophenotyping is the selected method for the differential diagnostic screening between reactive lymphocytosis and neoplastic B-cell chronic lymphoproliferative disorders (B-CLPD)...
  46. Ramadan K, Anderson J, McMullin M, Markey G. Idiopathic pure red cell aplasia: first report on CD8 positive lymphocytosis in bone marrow biopsy sections. J Clin Pathol. 2005;58:1118-20 pubmed
    ..A diffuse CD3 positive (CD8 positive, granzyme B negative) lymphocytosis of approximately 1500/mm3 was revealed by immunohistochemical staining...
  47. Moreira J, Rabe K, Cerhan J, Kay N, Wilson J, Call T, et al. Infectious complications among individuals with clinical monoclonal B-cell lymphocytosis (MBL): a cohort study of newly diagnosed cases compared to controls. Leukemia. 2013;27:136-41 pubmed publisher
    Although the risk of progression from monoclonal B-cell lymphocytosis (MBL) to chronic lymphocytic leukemia (CLL) has been well characterized, it is unknown whether other common complications associated with CLL, such as increased risk ..
  48. Xochelli A, Kalpadakis C, Gardiner A, Baliakas P, Vassilakopoulos T, Mould S, et al. Clonal B-cell lymphocytosis exhibiting immunophenotypic features consistent with a marginal-zone origin: is this a distinct entity?. Blood. 2014;123:1199-206 pubmed publisher
    The biological and clinical significance of a clonal B-cell lymphocytosis with an immunophenotype consistent with marginal-zone origin (CBL-MZ) is poorly understood...
  49. Hamilton V, Stone D, Cantor G. Translocation of the B cell receptor to lipid rafts is inhibited in B cells from BLV-infected, persistent lymphocytosis cattle. Virology. 2003;315:135-47 pubmed
    ..BLV) infection causes a significant polyclonal expansion of CD5(+), IgM+ B lymphocytes known as persistent lymphocytosis (PL) in approximately 30% of infected cattle...
  50. Koarada S, Wu Y, Yim Y, Wakeland E, Ridgway W. Nonobese diabetic CD4 lymphocytosis maps outside the MHC locus on chromosome 17. Immunogenetics. 2004;56:333-7 pubmed
    ..Nonobese diabetic (NOD) mice demonstrate peripheral T-cell lymphocytosis, and previous studies also suggested that the MHC region might control this phenotype...
  51. Rawstron A. Prevalence and characteristics of monoclonal B-cell lymphocytosis (MBL) in healthy individuals and the relationship with clinical disease. J Biol Regul Homeost Agents. 2004;18:155-60 pubmed
    ..These cells provide a tool for studying the events responsible for disease initiation...
  52. Kern W, Bacher U, Haferlach C, Dicker F, Alpermann T, Schnittger S, et al. Monoclonal B-cell lymphocytosis is closely related to chronic lymphocytic leukaemia and may be better classified as early-stage CLL. Br J Haematol. 2012;157:86-96 pubmed publisher
    ..with a chronic lymphocytic leukaemia (CLL)-phenotype in peripheral blood to discriminate between monoclonal B-lymphocytosis (MBL) and B-CLL...
  53. Molica S, Mauro F, Molica M, del Giudice I, Foa R. Monoclonal B-cell lymphocytosis: a reappraisal of its clinical implications. Leuk Lymphoma. 2012;53:1660-5 pubmed publisher
    Monoclonal B-cell lymphocytosis (MBL) is a recently defined medical condition that displays biological similarities to chronic lymphocytic leukemia (CLL), the most common subtype of adult leukemia in the Western world...
  54. Brown I, Mino Kenudson M, Deshpande V, Lauwers G. Intraepithelial lymphocytosis in architecturally preserved proximal small intestinal mucosa: an increasing diagnostic problem with a wide differential diagnosis. Arch Pathol Lab Med. 2006;130:1020-5 pubmed
    ..A wide variety of immunologic stimuli can raise intraepithelial lymphocyte numbers. Among the other common associations are enteric infection, autoimmune disease, drugs, and gastric Helicobacter infection...
  55. Ng D, Toure O, Wei M, Arthur D, Abbasi F, Fontaine L, et al. Identification of a novel chromosome region, 13q21.33-q22.2, for susceptibility genes in familial chronic lymphocytic leukemia. Blood. 2007;109:916-25 pubmed
    ..2. Two asymptomatic siblings who shared the 13q21.33-q22.2 at-risk haplotype exhibited CD5+ monoclonal B-cell lymphocytosis (MBL) on flow cytometry. One of these individuals also had a 13q14 deletion by FISH...
  56. Mossafa H, Tapia S, Flandrin G, Troussard X. Chromosomal instability and ATR amplification gene in patients with persistent and polyclonal B-cell lymphocytosis (PPBL). Leuk Lymphoma. 2004;45:1401-6 pubmed
    Forty-three patients with persistent and polyclonal B-cell lymphocytosis (PPBL) were studied...
  57. Rawstron A, Bennett F, Hillmen P. The biological and clinical relationship between CD5+23+ monoclonal B-cell lymphocytosis and chronic lymphocytic leukaemia. Br J Haematol. 2007;139:724-9 pubmed
    ..Patients with a CLL-phenotype monoclonal B-cell lymphocytosis (MBL) often have increasing CLL cell counts with time and some progress to a stage requiring treatment...
  58. Rawstron A, Shingles J, de Tute R, Bennett F, Jack A, Hillmen P. Chronic lymphocytic leukaemia (CLL) and CLL-type monoclonal B-cell lymphocytosis (MBL) show differential expression of molecules involved in lymphoid tissue homing. Cytometry B Clin Cytom. 2010;78 Suppl 1:S42-6 pubmed publisher
    ..The aim of this study was to screen for cell surface markers that could discriminate CLL-type MBL from CLL or identify CLL cases likely to have stable disease...
  59. Ferrajoli A, Shanafelt T, Ivan C, Shimizu M, Rabe K, Nouraee N, et al. Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia. Blood. 2013;122:1891-9 pubmed publisher
    ..We hypothesized that microRNAs (miRs) are involved in the transition from monoclonal B-cell lymphocytosis (MBL) to CLL and tested miR-15a/16-1 cluster, miR-21, and miR-155 expression in purified B cells of normal ..
  60. Hammer S, Greenson J. The clinical significance of duodenal lymphocytosis with normal villus architecture. Arch Pathol Lab Med. 2013;137:1216-9 pubmed publisher
  61. Ghia P, Caligaris Cappio F. Monoclonal B-cell lymphocytosis: right track or red herring?. Blood. 2012;119:4358-62 pubmed publisher
    Monoclonal B-cell lymphocytosis (MBL), a newly recognized entity found in approximately 3% of normal persons, precedes chronic lymphocytic leukemia...
  62. Collado R, Oliver I, Tormos C, Egea M, Miguel A, Cerda C, et al. Early ROS-mediated DNA damage and oxidative stress biomarkers in Monoclonal B Lymphocytosis. Cancer Lett. 2012;317:144-9 pubmed publisher
    Monoclonal B Lymphocytosis (MBL) is defined as asymptomatic monoclonal B-cell expansion characterised by a CLL-phenotype, but with less than 5×10(9)/l circulating cells...
  63. Tuire I, Marja Leena L, Teea S, Katri H, Jukka P, Päivi S, et al. Persistent duodenal intraepithelial lymphocytosis despite a long-term strict gluten-free diet in celiac disease. Am J Gastroenterol. 2012;107:1563-9 pubmed publisher
    ..Intraepithelial lymphocytosis may persist for years while villous morphology normalizes...
  64. Rachel J, Zucker M, Fox C, Plapp F, Menitove J, Abbasi F, et al. Monoclonal B-cell lymphocytosis in blood donors. Br J Haematol. 2007;139:832-6 pubmed
    ..In 2005, the term monoclonal B-cell lymphocytosis (MBL) was proposed to describe these findings...
  65. Dagklis A, Fazi C, Sala C, Cantarelli V, Scielzo C, Massacane R, et al. The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)-like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring. Blood. 2009;114:26-32 pubmed publisher
    ..Workshop on Chronic Lymphocytic Leukemia (IWCLL) guidelines for CLL, CLL-like monoclonal B lymphocytosis (MBL) is defined as the presence of less than 5 x 10(9)/L B lymphocytes in the peripheral blood...
  66. Shanafelt T, Kay N, Rabe K, Call T, Zent C, Maddocks K, et al. Brief report: natural history of individuals with clinically recognized monoclonal B-cell lymphocytosis compared with patients with Rai 0 chronic lymphocytic leukemia. J Clin Oncol. 2009;27:3959-63 pubmed publisher
    The diagnosis of monoclonal B-cell lymphocytosis (MBL) is used to characterize patients with a circulating population of clonal B cells, a total B-cell count of less than 5 x 10(9)/L, and no other features of a B-cell lymphoproliferative ..
  67. Shanafelt T, Ghia P, Lanasa M, Landgren O, Rawstron A. Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management. Leukemia. 2010;24:512-20 pubmed publisher
    ..with the phenotype of either CLL or another B-cell malignancy, a condition now designated monoclonal B-cell lymphocytosis (MBL)...