acute phase reaction

Summary

Summary: An early local inflammatory reaction to insult or injury that consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma.

Top Publications

  1. Ceron J, Eckersall P, Martýnez Subiela S. Acute phase proteins in dogs and cats: current knowledge and future perspectives. Vet Clin Pathol. 2005;34:85-99 pubmed
  2. Díez M, Santolaria F, Tejera A, Alemán M, Gonzalez Reimers E, Milena A, et al. Serum leptin levels in community acquired pneumonia (CAP) are related to nutritional status and not to acute phase reaction. Cytokine. 2008;42:156-160 pubmed publisher
    ..In conclusion, we suggest that in CAP patients, leptin does not act as an inflammatory reactant but as a nutritional marker...
  3. Gruys E, Toussaint M, Niewold T, Koopmans S. Acute phase reaction and acute phase proteins. J Zhejiang Univ Sci B. 2005;6:1045-56 pubmed
    A review of the systemic acute phase reaction with major cytokines involved, and the hepatic metabolic changes, negative and positive acute phase proteins (APPs) with function and associated pathology is given...
  4. Gao B. Cytokines, STATs and liver disease. Cell Mol Immunol. 2005;2:92-100 pubmed
    ..This article reviews the biological significance of STAT1, 2, 3, 4, 5, 6 in hepatic functions and diseases...
  5. Upragarin N, Landman W, Gaastra W, Gruys E. Extrahepatic production of acute phase serum amyloid A. Histol Histopathol. 2005;20:1295-307 pubmed publisher
    ..There is growing evidence that extrahepatic A-SAA formation may play a crucial role in amyloidogenesis and enhances amyloid formation at the site of SAA production...
  6. Kabaroff L, Rodriguez A, Quinton M, Boermans H, Karrow N. Assessment of the ovine acute phase response and hepatic gene expression in response to Escherichia coli endotoxin. Vet Immunol Immunopathol. 2006;113:113-24 pubmed
  7. Kino T, Rice K, Chrousos G. The PPARdelta agonist GW501516 suppresses interleukin-6-mediated hepatocyte acute phase reaction via STAT3 inhibition. Eur J Clin Invest. 2007;37:425-33 pubmed
    ..Peroxisome proliferator-activated receptor delta (PPARdelta), which binds to and is activated by a variety of fatty acids, was recently shown to have anti-inflammatory actions...
  8. Steen H, Giannitsis E, Sommerer C, Bahner U, Brandl M, Merbach C, et al. Acute phase reaction to gadolinium-DTPA in dialysis patients. Nephrol Dial Transplant. 2009;24:1274-7 pubmed publisher
    ..In an observational series, we found a remarkable frequency of peracute reactions after administration of Gd-DTPA used for cardiovascular evaluation before renal transplantation...
  9. Dziedzic T. Clinical significance of acute phase reaction in stroke patients. Front Biosci. 2008;13:2922-7 pubmed
    ..The acute phase reaction accompanies also intracerebral hemorrhage...

More Information

Publications62

  1. Srivastava T, Haney C, Alon U. Atorvastatin may have no effect on acute phase reaction in children after intravenous bisphosphonate infusion. J Bone Miner Res. 2009;24:334-7 pubmed publisher
    Intravenous bisphosphonate therapy is associated with acute phase reaction characterized by fever and musculoskeletal pain...
  2. Suk Danik J, Chasman D, Cannon C, Miller D, Zee R, Kozlowski P, et al. Influence of genetic variation in the C-reactive protein gene on the inflammatory response during and after acute coronary ischemia. Ann Hum Genet. 2006;70:705-16 pubmed
    ..Assessment of CRP genetic variants identified patients with higher and lower CRP elevation after acute coronary syndrome...
  3. Santini D, Vincenzi B, Caraglia M, Tonini G. A hitherto unreported high incidence of zoledronic acid-induced acute phase reaction in patients with cancer treatment-induced bone loss. Ann Oncol. 2007;18:201-2 pubmed
  4. Huang Y, Bassett M, Levin D, Montilla T, Ghio A. Acute phase reaction in healthy volunteers after bronchoscopy with lavage. Chest. 2006;129:1565-9 pubmed
    ..The scope of the acute phase response induced by the procedure is not fully evaluated. The purpose of the study is to characterize the acute phase response induced by bronchoscopy with BAL...
  5. Karrow N. Activation of the hypothalamic-pituitary-adrenal axis and autonomic nervous system during inflammation and altered programming of the neuroendocrine-immune axis during fetal and neonatal development: lessons learned from the model inflammagen, lipopo. Brain Behav Immun. 2006;20:144-58 pubmed
  6. Sriskandan S, Altmann D. The immunology of sepsis. J Pathol. 2008;214:211-23 pubmed
    ..Here the effect of bacterial superantigens appears to be a correlate of inflammatory activation, although the precise evolutionary role of the superantigens remains unclear...
  7. Clarkson R, Wayland M, Lee J, Freeman T, Watson C. Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression. Breast Cancer Res. 2004;6:R92-109 pubmed
  8. Bijl M, Bootsma H, Van Der Geld Y, Limburg P, Kallenberg C, van Rijswijk M. Serum amyloid P component levels are not decreased in patients with systemic lupus erythematosus and do not rise during an acute phase reaction. Ann Rheum Dis. 2004;63:831-5 pubmed
    ..Serum amyloid P component (SAP) and acute phase proteins like C-reactive protein contribute to the clearance of apoptotic cells. This response is diminished in systemic lupus erythematosus (SLE)...
  9. Maehira F, Miyagi I, Eguchi Y. Selenium regulates transcription factor NF-kappaB activation during the acute phase reaction. Clin Chim Acta. 2003;334:163-71 pubmed
    ..To clarify the implications of these observations, the effect of Se on nuclear factor (NF)-kappaB, which upregulates the CRP synthesis in the liver, was examined...
  10. Higgins M, Berridge B, Mills B, Schultze A, Gao H, Searfoss G, et al. Gene expression analysis of the acute phase response using a canine microarray. Toxicol Sci. 2003;74:470-84 pubmed
    ..In summary, this new genomic tool successfully detected basal canine gene expression and identified novel aspects of the acute phase response in dog that shed new light on mechanisms underlying inflammatory processes...
  11. Pepys M, Hirschfield G. C-reactive protein: a critical update. J Clin Invest. 2003;111:1805-12 pubmed
  12. Brull D, Serrano N, Zito F, Jones L, Montgomery H, Rumley A, et al. Human CRP gene polymorphism influences CRP levels: implications for the prediction and pathogenesis of coronary heart disease. Arterioscler Thromb Vasc Biol. 2003;23:2063-9 pubmed
    ..C-reactive protein (CRP) concentrations are predictive of cardiovascular disease, and levels are heritable, in part. We identified novel polymorphisms in the CRP gene and assessed their influence on CRP level...
  13. Lawrence S, Simpson Haidaris P. Regulated de novo biosynthesis of fibrinogen in extrahepatic epithelial cells in response to inflammation. Thromb Haemost. 2004;92:234-43 pubmed
  14. Roeb E, Purucker E, Gartung C, Geier A, Jansen B, Winograd R, et al. Effect of glutathione depletion and hydrophilic bile acids on hepatic acute phase reaction in rats with extrahepatic cholestasis. Scand J Gastroenterol. 2003;38:878-85 pubmed
    Extrahepatic cholestasis by biliary obstruction induces an acute phase reaction in the liver. It is a complex process involving cytokines, hormones and growth factors...
  15. Corbacho A, Valacchi G, Kubala L, Olano Martin E, Schock B, Kenny T, et al. Tissue-specific gene expression of prolactin receptor in the acute-phase response induced by lipopolysaccharides. Am J Physiol Endocrinol Metab. 2004;287:E750-7 pubmed
    ..These findings suggest a complex tissue-specific regulation of PRLR expression in the context of the APR...
  16. Gervois P, Kleemann R, Pilon A, Percevault F, Koenig W, Staels B, et al. Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofibrate. J Biol Chem. 2004;279:16154-60 pubmed
  17. Hardy G, Hardy I. Selenium: the Se-XY nutraceutical. Nutrition. 2004;20:590-3 pubmed
  18. Stein T, Morris J, Davies C, Weber Hall S, Duffy M, Heath V, et al. Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3. Breast Cancer Res. 2004;6:R75-91 pubmed
    ..Involution of the mammary gland is a complex process of controlled apoptosis and tissue remodelling. The aim of the project was to identify genes that are specifically involved in this process...
  19. Nilsen Hamilton M, Liu Q, Ryon J, Bendickson L, Lepont P, Chang Q. Tissue involution and the acute phase response. Ann N Y Acad Sci. 2003;995:94-108 pubmed
  20. Ferroni P, Rosa A, Di Franco M, Palmirotta R, Guadagni F, Davi G, et al. Prognostic significance of interleukin-6 measurement in the diagnosis of acute myocardial infarction in emergency department. Clin Chim Acta. 2007;381:151-6 pubmed
    ..Here, we investigated the role of interleukin-6 (IL-6) in the "triage" and risk assessment of patients admitted to emergency department (ED)...
  21. Turk R, Vnuk D, Svetina A, Flegar Meštrić Z, Flegar Mestri Z, Robić M, et al. Effect of splenectomy and autologous spleen transplantation on the serum platelet-activating factor acetylhydrolase (PAF-AH) activity and acute phase response (APR) in a porcine model. Inflammation. 2009;32:340-5 pubmed publisher
    ..Time-course increase of CRP, in all groups after surgery suggests post-injury inflammatory response due to tissue lesion during operation...
  22. Campillo Gimenez L, Laforge M, Fay M, Brussel A, Cumont M, Monceaux V, et al. Nonpathogenesis of simian immunodeficiency virus infection is associated with reduced inflammation and recruitment of plasmacytoid dendritic cells to lymph nodes, not to lack of an interferon type I response, during the acute phase. J Virol. 2010;84:1838-46 pubmed publisher
  23. Sköldstam L, Brudin L, Hagfors L, Johansson G. Weight reduction is not a major reason for improvement in rheumatoid arthritis from lacto-vegetarian, vegan or Mediterranean diets. Nutr J. 2005;4:15 pubmed
    ..Multiple logistic regression was used to analyse associations between the independent and the disease outcome variables...
  24. Kapral T, Stamm T, Machold K, Montag K, Smolen J, Aletaha D. Methotrexate in rheumatoid arthritis is frequently effective, even if re-employed after a previous failure. Arthritis Res Ther. 2006;8:R46 pubmed
    ..Re-employment of MTX despite prior inefficacy, but not re-employment of other DMARDs, is an effective therapeutic option, especially in those patients in whom the methotrexate dose of the original course was low...
  25. Denholm J, McBryde E, Eisen D. Mannose-binding lectin and susceptibility to tuberculosis: a meta-analysis. Clin Exp Immunol. 2010;162:84-90 pubmed publisher
    ..This analysis suggests that the relatively poorly characterized MBL2 genotypes reported are not associated significantly with susceptibility to pulmonary TB infection, but high MBL serum levels may be...
  26. Liang S, Nickerson Nutter C, Pittman D, Carrier Y, Goodwin D, Shields K, et al. IL-22 induces an acute-phase response. J Immunol. 2010;185:5531-8 pubmed publisher
    ..Based on these findings, we propose that downstream of its expression and impact in local tissue inflammation, circulating IL-22 can further induce changes in systemic physiology that is indicative of an acute-phase response...
  27. Jiang Z, Schatzmayr G, Mohnl M, Applegate T. Net effect of an acute phase response--partial alleviation with probiotic supplementation. Poult Sci. 2010;89:28-33 pubmed publisher
    ..Probiotic supplementation lessened the anorexic effects of LPS resulting in a trend toward BW gain improvement versus the LPS-NC...
  28. Zsila F. Chaperone-like activity of the acute-phase component human serum alpha 1-acid glycoprotein: inhibition of thermal- and chemical-induced aggregation of various proteins. Bioorg Med Chem Lett. 2010;20:1205-9 pubmed publisher
  29. Zsila F. Inhibition of heat- and chemical-induced aggregation of various proteins reveals chaperone-like activity of the acute-phase component and serine protease inhibitor human alpha(1)-antitrypsin. Biochem Biophys Res Commun. 2010;393:242-7 pubmed publisher
  30. Novosyadlyy R, Lelbach A, Sheikh N, Tron K, Pannem R, Ramadori G, et al. Temporal and spatial expression of IGF-I and IGFBP-1 during acute-phase response induced by localized inflammation in rats. Growth Horm IGF Res. 2009;19:51-60 pubmed publisher
    ..The liver is a central organ of both the IGF system and the APR because it releases most of IGF-I and IGFBP-1 in the circulation and is the main target organ for acute-phase-cytokines such as IL-6...
  31. Suzuki K, Peake J, Nosaka K, Okutsu M, Abbiss C, Surriano R, et al. Changes in markers of muscle damage, inflammation and HSP70 after an Ironman Triathlon race. Eur J Appl Physiol. 2006;98:525-34 pubmed
    ..HSP70 is released into the circulation as a function of exercise duration...
  32. Ray S, Boldogh I, Brasier A. STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen. Gastroenterology. 2005;129:1616-32 pubmed
    ..The mechanisms of how STAT3 activates target genes are unknown. Here we analyzed the biochemistry of STAT3 activation by interleukin (IL)-6 in hepatocellular carcinoma HepG2 and Balb/C mice...
  33. Ortega M, Miro O, Munoz A, Lopez B, Coll Vinent B, Sanchez M. [Factors associated with revisit and admission in patients complaining of fever that are discharged from the emergency department]. Med Clin (Barc). 2007;128:251-3 pubmed
    ..To identify factors associated with both emergency department (ED) revisit, and hospital admission of patients complaining of fever that have previously been seen and discharged from the ED...
  34. Battistelli S, Stefanoni M, Petrioli R, Genovese A, Dell avanzato R, Donati G, et al. Antiphospholipid antibodies and acute-phase response in non-metastatic colorectal cancer patients. Int J Biol Markers. 2008;23:31-5 pubmed
    ..To investigate the plasma levels and prevalence of the most common antiphospholipid antibodies, as well as their relationships with several plasma markers of inflammation, in order to characterize some aspects of cancer thrombophilia...
  35. Imagawa A, Hanafusa T. [Fulminant type 1 diabetes mellitus]. Rinsho Byori. 2010;58:216-24 pubmed
    ..In conclusion, all medical practitioners must remember that fulminant type 1 diabetes, an extremely rapidly progressing type of diabetes, does exist, and must pay special attention to avoid overlooking this disease...
  36. Osei Bimpong A, Meek J, Lewis S. ESR or CRP? A comparison of their clinical utility. Hematology. 2007;12:353-7 pubmed
  37. Topciu Shufta V, Begolli L, Kryeziu E. Lipoprotein (a) as an acute phase reactant in patients on chronic hemodialysis. Bosn J Basic Med Sci. 2010;10:19-25 pubmed
    ..Lp(a) levels correlated positively with CRP and negatively with HDL-C and serum albumin, in patients with elevated CRP, but not in healthy controls. According to the results Lp(a) reacts as an acute phase protein, in patients with APR...
  38. Saida T. [Treatment of NMO]. Rinsho Shinkeigaku. 2009;49:902-5 pubmed
    ..Physicians working on NMO treatment in Japan are very much hoping the initiation of well controlled clinical trials in order to treat our patients with more scientific strategy based on evidences...
  39. Haas M, Mooradian A. Regulation of high-density lipoprotein by inflammatory cytokines: establishing links between immune dysfunction and cardiovascular disease. Diabetes Metab Res Rev. 2010;26:90-9 pubmed publisher
    ..In this review, several of these connections are described and cytokine signalling related to HDLc is examined...
  40. Dow T, Rogers Nieman G, Holaskova I, Elsasser T, Dailey R. Tumor necrosis factor-alpha and acute-phase proteins in early pregnant ewes after challenge with peptidoglycan-polysaccharide. Domest Anim Endocrinol. 2010;39:147-54 pubmed publisher
    ..These factors were related to failure to establish pregnancy...
  41. Sehrawat S, Reddy P, Rajasagi N, Suryawanshi A, Hirashima M, Rouse B. Galectin-9/TIM-3 interaction regulates virus-specific primary and memory CD8 T cell response. PLoS Pathog. 2010;6:e1000882 pubmed publisher
    ..Our results indicate that manipulating galectin signals, as can be achieved using appropriate sugars, may represent a convenient and inexpensive approach to enhance acute and memory responses to a virus infection...
  42. Marques F, Sousa J, Coppola G, Falcao A, Rodrigues A, Geschwind D, et al. Kinetic profile of the transcriptome changes induced in the choroid plexus by peripheral inflammation. J Cereb Blood Flow Metab. 2009;29:921-32 pubmed publisher
    ..By modulating the composition of the cerebrospinal fluid, which will ultimately influence the brain parenchyma, the choroid plexus response to inflammation may be of relevance in brain homeostasis in health and disease...
  43. Schwartz M, Carlson R, Tipold A. Selective CD11a upregulation on neutrophils in the acute phase of steroid-responsive meningitis-arteritis in dogs. Vet Immunol Immunopathol. 2008;126:248-55 pubmed publisher
    ..Since sera of dogs suffering from SRMA selectively induce an upregulation of CD11a it can be suspected that this fluid contains one or multiple factors being responsible for this...
  44. Mori H, Yamanaka K, Matsuo K, Kurokawa I, Yasutomi Y, Mizutani H. Administration of Ag85B showed therapeutic effects to Th2-type cytokine-mediated acute phase atopic dermatitis by inducing regulatory T cells. Arch Dermatol Res. 2009;301:151-7 pubmed publisher
    ..Additionally, increased number of Foxp3(+) regulatory T cells were observed in the skin sections in Ag85B treated mice. The results of this study suggest that Ag85B DNA vaccine is a potential therapy for Th2 type dermatitis...
  45. Martín Ponce E, Santolaria F, Alemán Valls M, Gonzalez Reimers E, Martínez Riera A, Rodríguez Gaspar M, et al. Factors involved in the paradox of reverse epidemiology. Clin Nutr. 2010;29:501-6 pubmed publisher
    ..However, this phenomenon is controversial and the underlying reasons are poorly understood...
  46. Chiarla C, Giovannini I, Siegel J. Patterns of correlation of plasma ceruloplasmin in sepsis. J Surg Res. 2008;144:107-10 pubmed
    ..However, there is poor knowledge of the patterns of increase and correlation with changes in other biochemical variables, and our study has been performed to investigate this aspect...
  47. Into T, Inomata M, Nakashima M, Shibata K, Hacker H, Matsushita K. Regulation of MyD88-dependent signaling events by S nitrosylation retards toll-like receptor signal transduction and initiation of acute-phase immune responses. Mol Cell Biol. 2008;28:1338-47 pubmed
    ..Such an effect may reflect appropriate regulation of the acute-phase inflammatory responses in living organisms...
  48. Lachmann H, Sengul B, Yavuzsen T, Booth D, Booth S, Bybee A, et al. Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations. Rheumatology (Oxford). 2006;45:746-50 pubmed
    ..To prospectively monitor inflammatory activity over a prolonged period in a cohort of Turkish patients with FMF, their healthy relatives and healthy controls and to relate this to their MEFV genotypes...
  49. Lucia A, Smith L, Naidoo M, Gonzalez Freire M, Perez M, Rubio J, et al. McArdle disease: another systemic low-inflammation disorder?. Neurosci Lett. 2008;431:106-11 pubmed
    ..Our results support the rationale for prescribing carefully supervised exercise training in these patients...
  50. Renckens R, van Westerloo D, Roelofs J, Pater J, Schultz M, Florquin S, et al. Acute phase response impairs host defense against Pseudomonas aeruginosa pneumonia in mice. Crit Care Med. 2008;36:580-7 pubmed
    ..The objective was to study the influence of the acute phase response induced by sterile tissue injury on pulmonary host defense...
  51. Tsutsumi Y. [Necessity of novel single-antipsychotic-agent therapies for acute phase of schizophrenia]. Seishin Shinkeigaku Zasshi. 2006;108:619-23 pubmed
  52. de Rooij S, van Munster B, Korevaar J, Levi M. Cytokines and acute phase response in delirium. J Psychosom Res. 2007;62:521-5 pubmed
    ..This study aimed to examine the expression patterns of pro- and anti-inflammatory cytokines in elderly patients with and without delirium who were acutely admitted to the hospital...
  53. Uprichard J, Manning R, Laffan M. Monitoring heparin anticoagulation in the acute phase response. Br J Haematol. 2010;149:613-9 pubmed publisher
    ..This suggests that APTT may be a more accurate measure of anticoagulant effect in vivo than anti-Xa...