jaundice

Summary

Summary: A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.

Top Publications

  1. Owen P, Baghomian A, Lazarus J, Godkin A. An unusual cause of jaundice. BMJ. 2007;335:773-4 pubmed
  2. Teo C. Fatal outbreaks of jaundice in pregnancy and the epidemic history of hepatitis E. Epidemiol Infect. 2012;140:767-87 pubmed publisher
    Space-time clustering of people who fall acutely ill with jaundice, then slip into coma and death, is an alarming phenomenon, more markedly so when the victims are mostly or exclusively pregnant...
  3. Moucari R, Bernuau J, Nicand E, Cazals Hatem D, Valla D, Marcellin P, et al. Acute hepatitis E with severe jaundice: report of three cases. Eur J Gastroenterol Hepatol. 2007;19:1012-5 pubmed
    ..Infection is endemic in developing countries. Disease course is benign, and severe jaundice is rarely reported. Three patients presented to our department with symptomatic acute hepatitis...
  4. Pashapour N, Nikibahksh A, Golmohammadlou S. Urinary tract infection in term neonates with prolonged jaundice. Urol J. 2007;4:91-4; discussion 94 pubmed
    The aim of this study was to evaluate the frequency of urinary tract infection (UTI) in neonates with prolonged jaundice.
  5. Akhtar A, Shaheen M. Jaundice in African-American and Hispanic patients with AIDS. J Natl Med Assoc. 2007;99:1381-5 pubmed
    ..in hepatic biochemical tests are common in patients with acquired immunodeficiency syndrome (AIDS), overt jaundice is infrequent...
  6. Thoden J, Venhoff N, Miehle N, Klar M, Huzly D, Panther E, et al. Hepatitis E and jaundice in an HIV-positive pregnant woman. AIDS. 2008;22:909-10 pubmed publisher
  7. Yoon W, Ryu J, Yang K, Paik W, Lee J, Woo S, et al. A comparison of metal and plastic stents for the relief of jaundice in unresectable malignant biliary obstruction in Korea: an emphasis on cost-effectiveness in a country with a low ERCP cost. Gastrointest Endosc. 2009;70:284-9 pubmed publisher
    ..In countries where ERCP costs are low relative to those of metal stents (eg, Korea), initial endoscopic retrograde biliary drainage (ERBD) with a plastic stent is thought to be more economical...
  8. Regimbeau J, Fuks D, Bachellier P, Le Treut Y, Pruvot F, Navarro F, et al. Prognostic value of jaundice in patients with gallbladder cancer by the AFC-GBC-2009 study group. Eur J Surg Oncol. 2011;37:505-12 pubmed publisher
    b>Jaundice is frequent in patients with gallbladder cancer (GBC) and indicates advanced disease and, according to some teams, precludes routine operative exploration...
  9. Fuks D, Bartoli E, Delcenserie R, Yzet T, Celice P, Sabbagh C, et al. Biliary drainage, photodynamic therapy and chemotherapy for unresectable cholangiocarcinoma with jaundice. J Gastroenterol Hepatol. 2009;24:1745-52 pubmed publisher
    ..The combination of photodynamic therapy and biliary stenting seems to be beneficial in the palliative treatment of unresectable cholangiocarcinoma. We aimed to assess the accuracy of photodynamic therapy in a single centre...

More Information

Publications62

  1. Treeprasertsuk S, Silachamroon U, Krudsood S, Huntrup A, Suwannakudt P, Vannaphan S, et al. Ursodeoxycholic acid and artesunate in the treatment of severe falciparum malaria patients with jaundice. J Gastroenterol Hepatol. 2010;25:362-8 pubmed publisher
    ..The present study aims to determine the effects of combined UDCA and artesunate compared to placebo and artesunate on the improvement of liver tests in severe PF jaundiced patients...
  2. Mastoraki A, Karatzis E, Mastoraki S, Kriaras I, Sfirakis P, Geroulanos S. Postoperative jaundice after cardiac surgery. Hepatobiliary Pancreat Dis Int. 2007;6:383-7 pubmed
    ..The purpose of this study was to investigate the incidence and nature of postoperative jaundice in patients undergoing cardiac operation, to analyze the determinants, and to identify the clinical significance ..
  3. Chawla M, Bal C. Four cases of coexistent thyrotoxicosis and jaundice: results of radioiodine treatment and a brief review. Thyroid. 2008;18:289-92 pubmed publisher
  4. Varma V, Gupta S, Soin A, Nundy S. Does the presence of jaundice and/or a lump in a patient with gall bladder cancer mean that the lesion is not resectable?. Dig Surg. 2009;26:306-11 pubmed publisher
    The presence of jaundice or an abdominal lump in gall bladder cancer (GBC) is often translated to advanced and unresectable disease. We examined whether this was true.
  5. Inui K, Takahashi Y, Komeichi H, Katsuta Y, Shimizu S, Mizuno K. Successful transcatheter chemoembolization for acute jaundice in a patient with advanced hepatocellular carcinoma and portal vein tumor thrombosis: a case report. J Nippon Med Sch. 2009;76:217-20 pubmed
    ..0 and 20.0 mg/dL), and biliary obstruction by the tumor appeared to have caused this sudden jaundice. To treat the biliary obstruction, selective transcatheter chemoembolization (TACE) was performed via the feeding ..
  6. Gurley E, Halder A, Streatfield P, Sazzad H, Huda T, Hossain M, et al. Estimating the burden of maternal and neonatal deaths associated with jaundice in Bangladesh: possible role of hepatitis E infection. Am J Public Health. 2012;102:2248-54 pubmed publisher
    ..We estimated the population-based incidence of maternal and neonatal mortality associated with hepatitis E virus (HEV) in Bangladesh...
  7. Superina R, Magee J, Brandt M, Healey P, Tiao G, Ryckman F, et al. The anatomic pattern of biliary atresia identified at time of Kasai hepatoportoenterostomy and early postoperative clearance of jaundice are significant predictors of transplant-free survival. Ann Surg. 2011;254:577-85 pubmed publisher
    ..The goals of this study were to describe the clinical and anatomic features of infants undergoing Kasai portoenterostomy (KPE) for biliary atresia (BA) and to examine associations between these parameters and outcomes...
  8. Muhammed R, Bremner R, Protheroe S, Johnson T, Holden C, Murphy M. Resolution of parenteral nutrition-associated jaundice on changing from a soybean oil emulsion to a complex mixed-lipid emulsion. J Pediatr Gastroenterol Nutr. 2012;54:797-802 pubmed publisher
    Resolution of parenteral nutrition (PN)-associated jaundice has been reported in children given a reduced dose of intravenous fat using a fish oil-derived lipid emulsion...
  9. Smith R, Dajani K, Dodd S, Whelan P, Raraty M, Sutton R, et al. Preoperative resolution of jaundice following biliary stenting predicts more favourable early survival in resected pancreatic ductal adenocarcinoma. Ann Surg Oncol. 2008;15:3138-46 pubmed publisher
    ..The objective of this study was to investigate the influence of preoperative biliary stenting and resolution of jaundice on subsequent postoperative survival following resection for pancreatic cancer.
  10. Gao L, Liu W, Yang Q, Li H, Chen J, Tang Y, et al. Aggressive natural killer-cell leukemia with jaundice and spontaneous splenic rupture: a case report and review of the literature. Diagn Pathol. 2013;8:43 pubmed publisher
    ..We report an uncommon case of 36-year-old male who showed jaundice and spontaneous splenic rupture. The diagnosis was established by the biopsy of liver and spleen...
  11. Sharma J, Gairola S, Gaur R, Painuli R. The treatment of jaundice with medicinal plants in indigenous communities of the Sub-Himalayan region of Uttarakhand, India. J Ethnopharmacol. 2012;143:262-91 pubmed publisher
    ..A large number of plants and formulations have been claimed to have hepatoprotective activity. Jaundice is a symptom, indicative of the malfunctioning of the liver...
  12. Vine L, Shepherd K, Hunter J, Madden R, Thornton C, Ellis V, et al. Characteristics of Epstein-Barr virus hepatitis among patients with jaundice or acute hepatitis. Aliment Pharmacol Ther. 2012;36:16-21 pubmed publisher
    ..The demographics, clinical features and outcome of EBV hepatitis are incompletely understood, particularly in the elderly people...
  13. Wang X, Zhang A, Han Y, Wang P, Sun H, Song G, et al. Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease. Mol Cell Proteomics. 2012;11:370-80 pubmed publisher
    ..However, current diagnostic methods cannot predict typical Jaundice syndrome (JS) in patients with liver disease and little is known about the global metabolomic alterations that ..
  14. Burke B, Robbins J, Bird T, Hobbs C, Nesmith C, Tilford J. Trends in hospitalizations for neonatal jaundice and kernicterus in the United States, 1988-2005. Pediatrics. 2009;123:524-32 pubmed publisher
    ..nationally representative hospital discharge data to evaluate trends in the diagnosis and management of neonatal jaundice and the incidence of kernicterus in relation to the American Academy of Pediatrics hyperbilirubinemia clinical ..
  15. Tillmann H, Thompson A, Patel K, Wiese M, Tenckhoff H, Nischalke H, et al. A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice. Gastroenterology. 2010;139:1586-92, 1592.e1 pubmed publisher
    ..We analyzed the association between IL28B and the clinical presentation of acute hepatitis C virus (HCV) infection in a homogeneous population...
  16. Ahsan T, Ali H, Bkaht S, Ahmad N, Farooq M, Shaheer A, et al. Jaundice in falciparum malaria; changing trends in clinical presentation--a need for awareness. J Pak Med Assoc. 2008;58:616-21 pubmed
    To describe the clinical characteristics, laboratory parameters and prognostic factors in patients with falciparum malaria (FM) with jaundice.
  17. Syhavong B, Rasachack B, Smythe L, Rolain J, Roque Afonso A, Jenjaroen K, et al. The infective causes of hepatitis and jaundice amongst hospitalised patients in Vientiane, Laos. Trans R Soc Trop Med Hyg. 2010;104:475-83 pubmed publisher
    There is little information on the diverse infectious causes of jaundice and hepatitis in the Asiatic tropics...
  18. Lv J, Fu S, Guo J, Liu Y, Yuan H, Xiao X. [Primary research on daily administration times of rhubarb used to treat experimental jaundice in rats]. Zhongguo Zhong Yao Za Zhi. 2011;36:3506-10 pubmed
    To study the rational daily administration times of rhubarb when it is used to treat experimental jaundice in rats, at the same time, validate the accuracy and feasibility of the method which was previously established to research the ..
  19. Pelaez Luna M, Levy M, Arora A, Baron T, Rajan E. Mirizzi syndrome presenting as painless jaundice: a rare entity diagnosed by EUS. Gastrointest Endosc. 2008;67:974-5; discussion 975 pubmed publisher
  20. Nakamura H, Koga H, Wada M, Miyano G, Dizon R, Kato Y, et al. Reappraising the portoenterostomy procedure according to sound physiologic/anatomic principles enhances postoperative jaundice clearance in biliary atresia. Pediatr Surg Int. 2012;28:205-9 pubmed publisher
    ..Now PE involves an extended lateral dissection and a wide anastomosis (extended PE: EPE). We reappraised KOPE and created our-KOPE (OKOPE) by adhering strictly to its principles and techniques. We compared outcome of EPE and OKOPE...
  21. Walz B, Riecken B. [A young man with acute generalised jaundice and intermittent epigastric pain]. Dtsch Med Wochenschr. 2008;133:129-32 pubmed publisher
    A 24-year-old Iraqi was admitted to our hospital with acute generalised jaundice and intermittent epigastric pain. His family doctor suspected a viral hepatitis...
  22. Barr D, Ramdial P. Clinicopathological correlates in HIV seropositive tuberculosis cases presenting with jaundice after initiating antiretroviral therapy with a structured review of the literature. BMC Infect Dis. 2012;12:257 pubmed publisher
    The development of jaundice after initiation of HAART in HIV-TB co-infected patients is a challenging presentation in resource constrained settings, and is often attributed to drug induced liver injury (DILI)...
  23. Vallejo J, Gonzalez J. The use of the head louse as a remedy for jaundice in Spanish folk medicine: an overview. J Ethnobiol Ethnomed. 2013;9:52 pubmed publisher
    In Spain, head lice are considered a therapeutic resource for the treatment of jaundice. All folk remedies based on the ingestion of these insects meet in the present document, previously dispersed among a large number of references.
  24. Strassburg C. Gilbert-Meulengracht's syndrome and pharmacogenetics: is jaundice just the tip of the iceberg?. Drug Metab Rev. 2010;42:168-81 pubmed publisher
    ..The complexity hidden behind this pharmacogenetic abnormality is of profound significance for drug development and therapy...
  25. Park J, Hwang J, Kim H, Choe H, Kim Y, Kim H, et al. Castleman disease presenting with jaundice: a case with the multicentric hyaline vascular variant. Korean J Intern Med. 2007;22:113-7 pubmed
    ..A previous healthy 50 year-old man was hospitalized for right upper quadrant (RUQ) abdominal pain. He had jaundice and a 1 cm-sized lymph node in the right supraclavicular area...
  26. Hawkins W, Dematteo R, Jarnagin W, Ben Porat L, Blumgart L, Fong Y. Jaundice predicts advanced disease and early mortality in patients with gallbladder cancer. Ann Surg Oncol. 2004;11:310-5 pubmed
    In patients with gallbladder cancer, jaundice suggests tumor involvement of the porta hepatis. This study reports on the prevalence, etiology, and clinical significance of jaundice in patients with gallbladder cancer.
  27. Pasanen P, Partanen K, Pikkarainen P, Alhava E, Janatuinen E, Pirinen A. A comparison of ultrasound, computed tomography and endoscopic retrograde cholangiopancreatography in the differential diagnosis of benign and malignant jaundice and cholestasis. Eur J Surg. 1993;159:23-9 pubmed
    To assess the accuracy of ultrasonography (US), computed tomography (CT), and endoscopic retrograde cholangiopancreatography (ERCP) in distinguishing between benign and malignant causes of jaundice and cholestasis without jaundice.
  28. Garcia F, Nager A. Jaundice as an early diagnostic sign of urinary tract infection in infancy. Pediatrics. 2002;109:846-51 pubmed
    ..Previous studies have noted that jaundice may be one of the first signs of a bacterial infection in infants...
  29. Pelletier G, Roulot D, Davion T, Masliah C, Causse X, Oberti F, et al. A randomized controlled trial of ursodeoxycholic acid in patients with alcohol-induced cirrhosis and jaundice. Hepatology. 2003;37:887-92 pubmed
    ..assess the efficacy of ursodeoxycholic acid (UDCA) on the survival of patients with alcohol-induced cirrhosis and jaundice. We included patients with histologically proven alcohol-induced cirrhosis and serum bilirubin >50 micromol/L...
  30. Faust T, Reddy K. Postoperative jaundice. Clin Liver Dis. 2004;8:151-66 pubmed
    ..The type of surgery to be performed should also be reviewed. All patients with postoperative jaundice should be evaluated for a history of liver disease...
  31. Schapiro R, Maher M, Misdraji J. Case records of the Massachusetts General Hospital. Case 3-2006. A 63-year-old woman with jaundice and a pancreatic mass. N Engl J Med. 2006;354:398-406 pubmed
  32. Kochar D, Kaswan K, Kochar S, Sirohi P, Pal M, Kochar A, et al. A comparative study of regression of jaundice in patients of malaria and acute viral hepatitis. J Vector Borne Dis. 2006;43:123-9 pubmed
    b>Jaundice is one of the common manifestations of severe malaria in adults...
  33. Maisels M. Neonatal jaundice. Pediatr Rev. 2006;27:443-54 pubmed
  34. Hussaini S, O Brien C, Despott E, Dalton H. Antibiotic therapy: a major cause of drug-induced jaundice in southwest England. Eur J Gastroenterol Hepatol. 2007;19:15-20 pubmed
    To determine the incidence and causes of drug-induced jaundice in a rural community.
  35. Betjes M, Bajema I. The pathology of jaundice-related renal insufficiency: cholemic nephrosis revisited. J Nephrol. 2006;19:229-33 pubmed
    The spectrum of jaundice-related nephropathy can range from limited proximal tubulopathy to renal failure. The latter condition was known as cholemic nephrosis in the early literature on this subject...
  36. Ekpebegh C, Levitt N. A 40-year-old woman who developed jaundice during therapy for thyrotoxicosis. PLoS Med. 2006;3:e12 pubmed
  37. Sakar A, Kara E, Aydede H, Ayhan S, Celik P, Yorgancioglu A. A case of a small cell lung carcinoma presenting with jaundice due to pancreatic metastasis. Tuberk Toraks. 2005;53:181-4 pubmed
    ..incidence of pancreatic metastasis of lung cancer has been reported in autopsy series, symptomatic cases with jaundice due to that is very rare...
  38. Kerkar N, Gold D, Thung S, Shneider B. Jaundice accompanied by giant cell hepatitis and eosinophilia in childhood. Semin Liver Dis. 2004;24:107-11 pubmed
  39. Vuppalanchi R, Liangpunsakul S, Chalasani N. Etiology of new-onset jaundice: how often is it caused by idiosyncratic drug-induced liver injury in the United States?. Am J Gastroenterol. 2007;102:558-62; quiz 693 pubmed
    ..We conducted a study of adults with new-onset jaundice at a nonreferral community hospital to better understand the epidemiology of acute DILI.
  40. Rudenski A, Halsall D. Genetic testing for Gilbert's syndrome: how useful is it in determining the cause of jaundice?. Clin Chem. 1998;44:1604-9 pubmed
    ..Until these values for prevalence and penetrance are known, genetic testing for Gilbert's syndrome cannot be recommended on a routine basis...
  41. Roche S, Kobos R. Jaundice in the adult patient. Am Fam Physician. 2004;69:299-304 pubmed
    b>Jaundice in an adult patient can be caused by a wide variety of benign or life-threatening disorders. Organizing the differential diagnosis by prehepatic, intrahepatic, and posthepatic causes may help make the work-up more manageable...
  42. Prakash M, Poreddy V, Tiyyagura L, Bonacini M. Jaundice and hepatocellular damage associated with nevirapine therapy. Am J Gastroenterol. 2001;96:1571-4 pubmed
    ..Nevirapine has been associated with a skin rash in 32 to 48% of patients. Recent reports indicate that hepatic toxicity also occurs...
  43. Chung C, Buchman A. Postoperative jaundice and total parenteral nutrition-associated hepatic dysfunction. Clin Liver Dis. 2002;6:1067-84 pubmed
    Postoperative jaundice and TPN-induced hepatic abnormalities represent clinical situations that stem from multiple and frequently overlapping insults to the liver...
  44. Chan H, Tsang S, Hui Y, Leung N, Chan F, Sung J. The role of lamivudine and predictors of mortality in severe flare-up of chronic hepatitis B with jaundice. J Viral Hepat. 2002;9:424-8 pubmed
    Patients with chronic hepatitis B (CHB) may develop severe disease exacerbations (flare) with jaundice, and some may progress to fulminant hepatic failure...
  45. Pan G, French D, Mao W, Maruoka M, Risser P, Lee J, et al. Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice. J Immunol. 2001;167:6559-67 pubmed
    ..Taken together, these findings suggest that IL-17E is a unique pleiotropic cytokine and may be an important mediator of inflammatory and immune responses...
  46. Vaiphei K, Suri V, Bhalla A. Fever, jaundice, altered sensorium, with multiple systemic manifestations. Indian J Gastroenterol. 2007;26:82-6 pubmed
  47. O Donohue J, Oien K, Donaldson P, Underhill J, Clare M, MacSween R, et al. Co-amoxiclav jaundice: clinical and histological features and HLA class II association. Gut. 2000;47:717-20 pubmed
    b>Jaundice associated with co-amoxiclav has been increasingly recognised. We aimed to characterise its clinical and histological features and to investigate linkage with human leucocyte antigen class II haplotypes.
  48. de Filippis A, Nogueira R, Schatzmayr H, Tavares D, Jabor A, Diniz S, et al. Outbreak of jaundice and hemorrhagic fever in the Southeast of Brazil in 2001: detection and molecular characterization of yellow fever virus. J Med Virol. 2002;68:620-7 pubmed
    Between January and March 2001, an outbreak of jaundice and hemorrhagic fever occurred in the state of Minas Gerais, Southeast region of Brazil, in which a mortality rate of 53% was reported...
  49. Mazumder R, Mishra R, Mazumder H, Mukherjee P. Jaundice in falciparum malaria--some prospective observations. J Indian Med Assoc. 2002;100:312-4 pubmed
    ..The present prospective study of slide positive Plasmodium falciparum patients revealed a higher (17%) incidence of jaundice. This is much higher than reported earlier...
  50. Smith P, Larenas J, Contreras J, Cassigoli J, Venegas C, Rojas M, et al. Infectious haemolytic anaemia causes jaundice outbreaks in seawater-cultured coho salmon, Oncorhynchus kisutch (Walbaum), in Chile. J Fish Dis. 2006;29:709-15 pubmed
    ..At necropsy, fish from field cases exhibited signs of jaundice accompanied by pale light-brown livers and dark spleens...
  51. Davenport M, Betalli P, D Antiga L, Cheeseman P, Mieli Vergani G, Howard E. The spectrum of surgical jaundice in infancy. J Pediatr Surg. 2003;38:1471-9 pubmed
    Conjugated jaundice arising during infancy may be caused by a number of different surgical conditions...
  52. Suzuki A, Kumashiro R, Shirachi M, Kuroki M, Suzuki H, Tanikawa K, et al. Markedly prolonged jaundice from simultaneous infection with hepatitis E virus and leptospira. Kurume Med J. 2003;50:155-9 pubmed
    ..Leptospirosis appeared to have altered the course of hepatitis E virus infection in this patient, even though infection with Leptospira was cleared with antibiotics by 50 days after the onset of the hepatitis symptoms...
  53. Bansal V, Schuchert V. Jaundice in the intensive care unit. Surg Clin North Am. 2006;86:1495-502 pubmed
    Hyperbilirubinemia, or jaundice, is common in the ICU, with incidence up to 40% among critically ill patients. Unfortunately, it is poorly understood in the critically ill, and too often presents a diagnostic dilemma to the ICU physician...