heterotopic ossification

Summary

Summary: The development of bony substance in normally soft structures.

Top Publications

  1. Aizawa T, Sato T, Sasaki H, Kusakabe T, Morozumi N, Kokubun S. Thoracic myelopathy caused by ossification of the ligamentum flavum: clinical features and surgical results in the Japanese population. J Neurosurg Spine. 2006;5:514-9 pubmed
    ..Data obtained in patients with thoracic myelopathy caused by ossification of the ligamentum flavum (OLF) were retrospectively reviewed to clarify clinical features and surgical outcomes in the Japanese population...
  2. Wysocki R, Cohen M. Radioulnar heterotopic ossification after distal biceps tendon repair: results following surgical resection. J Hand Surg Am. 2007;32:1230-6 pubmed
    The purpose of this study is to evaluate the clinical outcome of patients who had excision of a radioulnar heterotopic ossification (HO) as a complication of a distal biceps tendon repair...
  3. Shah R, Moncayo V, Smitson R, Pierre Jerome C, Terk M. Recombinant human bone morphogenetic protein 2-induced heterotopic ossification of the retroperitoneum, psoas muscle, pelvis and abdominal wall following lumbar spinal fusion. Skeletal Radiol. 2010;39:501-4 pubmed publisher
    ..Subsequent computed tomography (CT) scans and X-rays revealed heterotopic ossification of the left psoas muscle, pelvis, and anterior abdominal wall...
  4. Namazi H, Mozaffarian K. Levothyroxin inhibits heterotopic ossification: an experimental study in rabbits. J Trauma. 2008;65:849-51 pubmed publisher
    b>Heterotopic ossification is a common complication of surgery or trauma.
  5. Genet F, Marmorat J, Lautridou C, Schnitzler A, Mailhan L, Denormandie P. Impact of late surgical intervention on heterotopic ossification of the hip after traumatic neurological injury. J Bone Joint Surg Br. 2009;91:1493-8 pubmed publisher
    b>Heterotopic ossification (HO) of the hip after injury to the central nervous system can lead to joint ankylosis. Surgery is usually delayed to avoid recurrence, even if the functional status is affected...
  6. Pantazis G, Tsitsopoulos P, Bibis A, Mihas C, Chatzistamou I, Kouzelis C. Symptomatic ossification of the ligamentum flavum at the lumbar spine: a retrospective study. Spine (Phila Pa 1976). 2008;33:306-11 pubmed publisher
    ..A retrospective study on 9 patients treated for ossification of the ligamentum flavum (OLF) at the lumbar spine...
  7. Shimono K, Morrison T, Tung W, Chandraratna R, Williams J, Iwamoto M, et al. Inhibition of ectopic bone formation by a selective retinoic acid receptor alpha-agonist: a new therapy for heterotopic ossification?. J Orthop Res. 2010;28:271-7 pubmed publisher
    b>Heterotopic ossification (HO) consists of formation of ectopic cartilage followed by endochondral bone and is triggered by major surgeries, large wounds, and other conditions...
  8. Jackson W, Aragon A, Bulken Hoover J, Nesti L, Tuan R. Putative heterotopic ossification progenitor cells derived from traumatized muscle. J Orthop Res. 2009;27:1645-51 pubmed publisher
    b>Heterotopic ossification (HO) is a frequent complication following combat-related trauma, but the pathogenesis of traumatic HO is poorly understood...
  9. Xu J, Wu T, Wu G, Zhong Z, Tang Y, Chen J. Leptin expression by heterotopic ossification-isolated tissue in rats with Achilles' tenotomy. Saudi Med J. 2009;30:605-10 pubmed
    To set up heterotopic ossification (HO) models according to McClure and determine whether leptin messenger ribonucleic acid (mRNA) and protein are expressed in HO-isolated tissue.

More Information

Publications62

  1. Safaz I, Alaca R, Bozlar U, Yasar E. Bilateral sciatic nerve entrapment due to heterotopic ossification in a traumatic brain-injured patient. Am J Phys Med Rehabil. 2008;87:65-7 pubmed
    ..He was also diagnosed to have bilateral sciatic nerve entrapment attributable to hip heterotopic ossification (HO)...
  2. Strauss J, Chen S, Shah A, Coon A, Dickler A. Cost of radiotherapy versus NSAID administration for prevention of heterotopic ossification after total hip arthroplasty. Int J Radiat Oncol Biol Phys. 2008;71:1460-4 pubmed publisher
    b>Heterotopic ossification (HO), or abnormal bone formation, is a common sequela of total hip arthroplasty. This abnormal bone can impair joint function and must be surgically removed to restore mobility...
  3. Vanden Bossche L, Van Maele G, Wojtowicz I, Bru I, Decorte T, De Muynck M, et al. Free radical scavengers versus methylprednisolone in the prevention of experimentally induced heterotopic ossification. J Orthop Res. 2009;27:748-51 pubmed publisher
    The etiology of heterotopic ossification (HO) is still obscure, it is difficult to devise an effective preventive or therapeutic approach. The options for the prevention of HO are still limited...
  4. Adegbite N, Xu M, Kaplan F, Shore E, Pignolo R. Diagnostic and mutational spectrum of progressive osseous heteroplasia (POH) and other forms of GNAS-based heterotopic ossification. Am J Med Genet A. 2008;146A:1788-96 pubmed publisher
    Progressive osseous heteroplasia (POH) is a rare, disabling disease of heterotopic ossification (HO) that progresses from skin and subcutaneous tissues into deep skeletal muscle...
  5. Forsberg J, Pepek J, Wagner S, Wilson K, Flint J, Andersen R, et al. Heterotopic ossification in high-energy wartime extremity injuries: prevalence and risk factors. J Bone Joint Surg Am. 2009;91:1084-91 pubmed publisher
    b>Heterotopic ossification in the extremities remains a common complication in the setting of high-energy wartime trauma, particularly in blast-injured amputees and in those in whom the definitive amputation was performed within the zone of ..
  6. Guo J, Tang N, Yang H, Qin L, Leung K. Impact of surgical approach on postoperative heterotopic ossification and avascular necrosis in femoral head fractures: a systematic review. Int Orthop. 2010;34:319-22 pubmed publisher
    b>Heterotopic ossification (HO) and avascular necrosis (AVN) have been identified as post-traumatic complications of femoral head fractures and may lead to a restriction in hip function and permanent disability...
  7. Cipriano C, Pill S, Keenan M. Heterotopic ossification following traumatic brain injury and spinal cord injury. J Am Acad Orthop Surg. 2009;17:689-97 pubmed
    b>Heterotopic ossification associated with neurologic injury, or neurogenic heterotopic ossification, tends to form at major synovial joints surrounded by spastic muscles...
  8. Forsberg J, Potter B. Heterotopic ossification in wartime wounds. J Surg Orthop Adv. 2010;19:54-61 pubmed
    b>Heterotopic ossification (HO) refers to the formation of mature lamellar bone in nonosseous tissue...
  9. Oertel S, Schneider U, Keel M, Lütolf U, Bosshard G. Prophylaxis of heterotopic ossification in patients sedated after polytrauma : medical and ethical considerations. Strahlenther Onkol. 2008;184:212-7 pubmed publisher
    b>Heterotopic ossification (HO) often follows acetabular fractures after multitrauma. Irradiation is a mean for prophylaxis...
  10. Lin L, Shen Q, Xue T, Yu C. Heterotopic ossification induced by Achilles tenotomy via endochondral bone formation: expression of bone and cartilage related genes. Bone. 2010;46:425-31 pubmed publisher
    Animal model for heterotopic ossification (HO) induced by Achilles tenotomy in rats has been used in the literature. However, the molecular mechanism remains unclear...
  11. Dilling C, Wada A, Lazard Z, Salisbury E, Gannon F, Vadakkan T, et al. Vessel formation is induced prior to the appearance of cartilage in BMP-2-mediated heterotopic ossification. J Bone Miner Res. 2010;25:1147-56 pubmed publisher
    b>Heterotopic ossification (HO), or endochondral bone formation at nonskeletal sites, often results from traumatic injury and can lead to devastating consequences...
  12. Patel H, Silverman C, Carrascosa L, Malkani A, Yashar C. Evaluation of scrotal and testicular radiation doses for heterotopic ossification prophylaxis. Am J Orthop (Belle Mead NJ). 2008;37:E163-6 pubmed
    The majority of patients with heterotopic ossification are males with traumatic injuries in the hip/femur region...
  13. Kerr E, Jawahar A, Kay S, Cavanaugh D, Nunley P. Implant design may influence delayed heterotopic ossification after total disk arthroplasty in lumbar spine. Surg Neurol. 2009;72:747-51; discussion 751 pubmed publisher
    ..The purpose of the present submission is to report a case of delayed heterotopic ossification (HO) after TDA that suggests that the keel-based design of the implant might have contributed to the ..
  14. Kong Q, Ma X, Li F, Guo Z, Qi Q, Li W, et al. COL6A1 polymorphisms associated with ossification of the ligamentum flavum and ossification of the posterior longitudinal ligament. Spine (Phila Pa 1976). 2007;32:2834-8 pubmed publisher
    ..A case-control association study was conducted to investigate the genetic etiology for ossification of the ligamentum flavum (OLF) and ossification of the posterior longitudinal ligament of the spine (OPLL)...
  15. Mitsionis G, Lykissas M, Kalos N, Paschos N, Beris A, Georgoulis A, et al. Functional outcome after excision of heterotopic ossification about the knee in ICU patients. Int Orthop. 2009;33:1619-25 pubmed publisher
    ..in the range of movement in the knee joint, sitting ability, and overall ambulation in patients with heterotopic ossification of the knee joint who underwent surgical excision of ectopic bone...
  16. Chalidis B, Stengel D, Giannoudis P. Early excision and late excision of heterotopic ossification after traumatic brain injury are equivalent: a systematic review of the literature. J Neurotrauma. 2007;24:1675-86 pubmed
    b>Heterotopic ossification (HO) is a common complication in patients with coma after brain injury...
  17. Chandrasenan J, Dias R, Lunn P. Heterotopic ossification after the Outerbridge-Kashiwagi procedure in the elbow. J Shoulder Elbow Surg. 2008;17:e15-7 pubmed publisher
  18. Rama K, Vendittoli P, Ganapathi M, Borgmann R, Roy A, Lavigne M. Heterotopic ossification after surface replacement arthroplasty and total hip arthroplasty: a randomized study. J Arthroplasty. 2009;24:256-62 pubmed publisher
    With a randomized clinical trial, we compared the incidence and severity of heterotopic ossification in cohorts of patients who have undergone either surface replacement arthroplasty or total hip arthroplasty at a minimum follow-up of 1 ..
  19. Macfarlane R, Ng B, Gamie Z, El Masry M, Velonis S, Schizas C, et al. Pharmacological treatment of heterotopic ossification following hip and acetabular surgery. Expert Opin Pharmacother. 2008;9:767-86 pubmed publisher
    b>Heterotopic ossification is a common complication following total hip arthroplasty and surgery following acetabular trauma. It is associated with pain and a decreased range of movement...
  20. Devnani A. Management of heterotopic ossification affecting both hips and knees. Singapore Med J. 2008;49:501-4 pubmed
    The management of heterotopic ossification is controversial. This is a rare case affecting both hips and knees of a 22-year-old woman that prevented her from walking...
  21. Berndt C, Ganko A, Whitehouse S, Crawford R. Heterotopic ossification within an arthroscopic portal after uneventful partial meniscectomy. Knee. 2008;15:416-8 pubmed publisher
    ..medial meniscectomy for a meniscal tear whose postoperative course was complicated by the development of heterotopic ossification (HO) within the medial arthroscopic portal...
  22. Blokhuis T, Frölke J. Is radiation superior to indomethacin to prevent heterotopic ossification in acetabular fractures?: a systematic review. Clin Orthop Relat Res. 2009;467:526-30 pubmed publisher
    b>Heterotopic ossification is a well-known complication after fixation of an acetabular fracture. Indomethacin and radiation therapy are used as prophylaxis to prevent heterotopic ossification...
  23. Citak M, Kendoff D, O Loughlin P, Pearle A. Heterotopic ossification post navigated high tibial osteotomy. Knee Surg Sports Traumatol Arthrosc. 2009;17:352-5 pubmed publisher
    The authors present a case of heterotopic ossification (HO) following a navigated high tibial osteotomy which necessitated a second surgical procedure...
  24. Axelrad T, Steen B, Lowenberg D, Creevy W, Einhorn T. Heterotopic ossification after the use of commercially available recombinant human bone morphogenetic proteins in four patients. J Bone Joint Surg Br. 2008;90:1617-22 pubmed publisher
    b>Heterotopic ossification occurring after the use of commercially available bone morphogenetic proteins has not been widely reported...
  25. Lee J, Jung T, Kim H, Jang J, Lee S. Analysis of the incidence and clinical effect of the heterotopic ossification in a single-level cervical artificial disc replacement. Spine J. 2010;10:676-82 pubmed publisher
    b>Heterotopic ossification (HO) is a well-known phenomenon occurring after joint arthroplasty. However, its incidence and clinical effects have not yet been clearly identified with cervical disc replacement.
  26. Romanini E, Magaletti M, D Aviera L, Antonelli S. Severe heterotopic ossification after total hip arthroplasty in Schnitzler syndrome. Hip Int. 2010;20:284-6 pubmed
    ..We present the case of a patient affected by Schnitzler syndrome who developed Della Valle type C heterotopic ossification after total hip arthroplasty...
  27. Yayama T, Uchida K, Kobayashi S, Kokubo Y, Sato R, Nakajima H, et al. Thoracic ossification of the human ligamentum flavum: histopathological and immunohistochemical findings around the ossified lesion. J Neurosurg Spine. 2007;7:184-93 pubmed
  28. Carfrae M, Foyt D. Auricular ossification resulting in external auditory canal stenosis. Ear Nose Throat J. 2008;87:148-9 pubmed
    ..The patient was successfully treated with meatoplasty. Pathologic examination of the removed specimen revealed osseous metaplasia...
  29. Suchomel P, Jurák L, Benes V, Brabec R, Bradác O, Elgawhary S. Clinical results and development of heterotopic ossification in total cervical disc replacement during a 4-year follow-up. Eur Spine J. 2010;19:307-15 pubmed publisher
    ..Ongoing data collection and increasing number of studies describing heterotopic ossification (HO) resulting in decreased mobility of implants, forced us to carefully evaluate our long-term clinical ..
  30. Kircher J, Martinek V, Mittelmeier W. Heterotopic ossification after minimally invasive rotator cuff repair. Arthroscopy. 2007;23:1359.e1-3 pubmed
    b>Heterotopic ossification is a common phenomenon after spinal cord injury, head injury, neurologic disorders, burns and other trauma, and joint arthroplasty...
  31. Sterneberg Vos H, Winnepenninckx V, Frank J, Kelleners Smeets N. Ossification of the auricle. Int J Dermatol. 2007;46 Suppl 3:42-4 pubmed
    ..Such unphysiological replacement has been reported in association with local trauma, inflammation, systemic diseases, and hypothermia. Here, we report a patient with unilateral ossification of the auricle secondary to frostbite...
  32. Handschin A, Trentz O, Hemmi S, Wedler V, Trentz O, Giovanoli P, et al. Leptin increases extracellular matrix mineralization of human osteoblasts from heterotopic ossification and normal bone. Ann Plast Surg. 2007;59:329-33 pubmed
    b>Heterotopic ossification (HO) is the pathologic formation of bone in soft tissue. The exact pathomechanism is unknown but probably involves a disturbed osteoblast differentiation...
  33. Kan L, Liu Y, McGuire T, Berger D, Awatramani R, Dymecki S, et al. Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification. Stem Cells. 2009;27:150-6 pubmed publisher
    b>Heterotopic ossification (HO), the abnormal formation of true marrow-containing bone within extraskeletal soft tissues, is a serious bony disorder that may be either acquired or hereditary...
  34. Jensen A, Viozzi C, Foote R. Long-term results of radiation prophylaxis for heterotopic ossification in the temporomandibular joint. J Oral Maxillofac Surg. 2010;68:1100-5 pubmed publisher
    To assess the long-term efficacy and toxicity of radiation therapy (RT) for postoperative prophylaxis of recurrent heterotopic ossification (HO) in the temporomandibular joint (TMJ).
  35. McAfee P, Cunningham B, Devine J, Williams E, Yu Yahiro J. Classification of heterotopic ossification (HO) in artificial disk replacement. J Spinal Disord Tech. 2003;16:384-9 pubmed
    ..8949 (P = 0.01). This classification of heterotopic ossification, periannular calcification, and ectopic bone formation associated with total disk arthroplasty proved to ..
  36. Sugita A, Hashimoto J, Maeda A, Kobayashi J, Hirao M, Masuhara K, et al. Heterotopic ossification in bilateral knee and hip joints after long-term sedation. J Bone Miner Metab. 2005;23:329-32 pubmed
  37. Valencia H, Gavín C. Infrapatellar heterotopic ossification after anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 2007;15:39-42 pubmed
    ..report a case of ACL reconstruction using an autologous patellar tendon graft, where great infrapatellar heterotopic ossification occurred post-operatively. We found no similar cases in the literature...
  38. Back D, Smith J, Dalziel R, Young D, Shimmin A. Incidence of heterotopic ossification after hip resurfacing. ANZ J Surg. 2007;77:642-7 pubmed
    b>Heterotopic ossification has been noted around total hip arthoplasty in numerous studies. With hip resurfacing growing in popularity, we have prospectively evaluated the incidence in a cohort undergoing hip resurfacing.
  39. Cullen N, Bayley M, Bayona N, Hilditch M, Aubut J. Management of heterotopic ossification and venous thromboembolism following acquired brain injury. Brain Inj. 2007;21:215-30 pubmed
    To evaluate the effectiveness of interventional strategies for the common complications of heterotopic ossification (HO) and venous thromboembolism (VTE) following acquired brain injury (ABI).
  40. Mehren C, Suchomel P, Grochulla F, Barsa P, Sourkova P, Hradil J, et al. Heterotopic ossification in total cervical artificial disc replacement. Spine (Phila Pa 1976). 2006;31:2802-6 pubmed
    ..Prospective clinical study enrolled in 2 centers (Munich and Liberec) as part of a prospective European multicenter study with ProDisc C (Synthes Inc., Paoli, PA)...
  41. Ince A, Sauer U, Wollmerstedt N, Hendrich C. No migration of acetabular cups after prophylaxis for heterotopic ossification. Clin Orthop Relat Res. 2007;461:125-9 pubmed
    The possibility of migration of cementless cups in total joints after prophylaxis of heterotopic ossification with irradiation or nonsteroidal antiinflammatory drugs is a concern...
  42. Chauveau C, Devedjian J, Blary M, Delecourt C, Hardouin P, Jeanfils J, et al. Gene expression in human osteoblastic cells from normal and heterotopic ossification. Exp Mol Pathol. 2004;76:37-43 pubmed
    b>Heterotopic ossification (HO), a possible complication of head injury, develops in sites where it is not normally present like at the vicinity of joints...
  43. Zehetgruber H, Grübl A, Goll A, Schwameis E, Wurnig C, Giurea A. [Prevention of heterotopic ossification after THA with indomethacin: analysis of risk factors]. Z Orthop Ihre Grenzgeb. 2005;143:631-7 pubmed
    ..The aim of this prospective study was to reveal risk factors for the development of postoperative ossifications in patients who underwent a 7-day course of indomethacin therapy...
  44. Pape H, Marsh S, Morley J, Krettek C, Giannoudis P. Current concepts in the development of heterotopic ossification. J Bone Joint Surg Br. 2004;86:783-7 pubmed
  45. Dudkiewicz I, Cohen I, Horowitz S, Regev S, Perelman M, Chechik A, et al. Colchicine inhibits heterotopic ossification: experimental study in rabbits. Isr Med Assoc J. 2005;7:31-4 pubmed
    b>Heterotopic ossification is a common complication of hip surgery and musculoskeletal or brain trauma.
  46. Fijn R, Koorevaar R, Brouwers J. Prevention of heterotopic ossification after total hip replacement with NSAIDs. Pharm World Sci. 2003;25:138-45 pubmed
    ..Non steroidal anti-inflammatory drugs (NSAIDs) and prophylactic radiotherapy can prevent ectopic bone formation around the hip after total hip arthroplasty...
  47. Bartlett C, Rapuano B, Lorich D, Wu T, Anderson R, Tomin E, et al. Early changes in prostaglandins precede bone formation in a rabbit model of heterotopic ossification. Bone. 2006;38:322-32 pubmed
    We have tested the hypothesis that the formation of heterotopic ossification (HO) in a rabbit model is correlated with a local increase in specific prostaglandins that may modulate mechanisms of ossification...
  48. Persson P, Nilsson O, Berggren A. Do non-steroidal anti-inflammatory drugs cause endoprosthetic loosening? A 10-year follow-up of a randomized trial on ibuprofen for prevention of heterotopic ossification after hip arthroplasty. Acta Orthop. 2005;76:735-40 pubmed
    ..Non-steroidal anti-inflammatory drugs (NSAIDs) are known to be potent inhibitors of new bone formation. We investigated whether NSAIDs given at surgery influence the long-term results after total hip arthroplasty (THA)...
  49. Tokala D, Lam K, Prince H. Ossification of the proximal thoracic ligamenta flava causing acute myelopathy in a Caucasian: case report and literature review. Spinal Cord. 2007;45:310-3 pubmed
    ..Case report and literature review...
  50. McCulloch P, Bush Joseph C. Massive heterotopic ossification complicating iliopsoas tendon lengthening: a case report. Am J Sports Med. 2006;34:2022-5 pubmed
  51. Lynch J, Jenkins M, Smith D, Bellabarba C. Bilateral exercise-induced compartment syndrome of the thigh and leg associated with massive heterotopic ossification. A case report. J Bone Joint Surg Am. 2006;88:2265-9 pubmed
  52. Board T, Karva A, Board R, Gambhir A, Porter M. The prophylaxis and treatment of heterotopic ossification following lower limb arthroplasty. J Bone Joint Surg Br. 2007;89:434-40 pubmed
    b>Heterotopic ossification following joint replacement in the lower limb occurs in 3% to 90% of cases...
  53. Hendricks H, Geurts A, van Ginneken B, Heeren A, Vos P. Brain injury severity and autonomic dysregulation accurately predict heterotopic ossification in patients with traumatic brain injury. Clin Rehabil. 2007;21:545-53 pubmed
    To assess brain injury severity, autonomic dysregulation and systemic infection as risk factors for the occurrence of heterotopic ossification in patients with severe traumatic brain injury.