Summary: Changes in quantitative and qualitative composition of MICROBIOTA. The changes may lead to altered host microbial interaction or homeostatic imbalance that can contribute to a disease state often with inflammation.

Top Publications

  1. Hickman D, Jones M, Zhu S, Kirkpatrick E, Ostrov D, Wang X, et al. The effect of malnutrition on norovirus infection. MBio. 2014;5:e01032-13 pubmed publisher
    ..Finally, both norovirus infection and malnutrition independently alter the composition of the intestinal microbiota in substantial and overlapping ways. ..
  2. Shi J, Wang Y, He J, Li P, Jin R, Wang K, et al. Intestinal microbiota contributes to colonic epithelial changes in simulated microgravity mouse model. FASEB J. 2017;31:3695-3709 pubmed publisher
    ..We further demonstrate that alteration in gastrointestinal motility may contribute to HU-associated dysbiosis. These animal results emphasize the necessity of evaluating astronauts' intestinal homeostasis during distant ..
  3. Espín J, Gonzalez Sarrias A, Tomas Barberan F. The gut microbiota: A key factor in the therapeutic effects of (poly)phenols. Biochem Pharmacol. 2017;139:82-93 pubmed publisher
    ..The review will focus in those PPs that are known to be metabolized by gut microbiota resulting in bioactive metabolites. ..
  4. Zhu A, Chen J, Wu P, Luo M, Zeng Y, Liu Y, et al. Cationic Polystyrene Resolves Nonalcoholic Steatohepatitis, Obesity, and Metabolic Disorders by Promoting Eubiosis of Gut Microbiota and Decreasing Endotoxemia. Diabetes. 2017;66:2137-2143 pubmed publisher
    ..Gut dysbiosis, characterized as an increase of the phylum Firmicutes and a decrease of Bacteroidetes and Akkermansia ..
  5. Singh S, Wilson M, Ritz N, Lin H. Autophagy Genes of Host Responds to Disruption of Gut Microbial Community by Antibiotics. Dig Dis Sci. 2017;62:1486-1497 pubmed publisher
    ..Here, we investigated the effect of antibiotic-induced disruption of the gut microbiome (dysbiosis) on autophagy gene expression and the expression of antimicrobial peptides/protein (AMP) over time...
  6. Jena P, Sheng L, Liu H, Kalanetra K, Mirsoian A, Murphy W, et al. Western Diet-Induced Dysbiosis in Farnesoid X Receptor Knockout Mice Causes Persistent Hepatic Inflammation after Antibiotic Treatment. Am J Pathol. 2017;187:1800-1813 pubmed publisher
    ..Our data revealed that Lactococcus, Lactobacillus, and Coprococcus protect the liver from inflammation. ..
  7. Wang W, Zhu Y, Chen X. Selective Imaging of Gram-Negative and Gram-Positive Microbiotas in the Mouse Gut. Biochemistry. 2017;56:3889-3893 pubmed publisher
    ..This chemical method should be broadly applicable to different gut microbiota research fields and other bacterial communities studied in microbiology...
  8. Mima K, Nakagawa S, Sawayama H, Ishimoto T, Imai K, Iwatsuki M, et al. The microbiome and hepatobiliary-pancreatic cancers. Cancer Lett. 2017;402:9-15 pubmed publisher
    ..Accumulating evidence from animal models suggests that specific microbes and microbial dysbiosis can potentiate hepatobiliary-pancreatic tumor development by damaging DNA, activating oncogenic signaling ..
  9. Ho K, Varga J. Early-Life Gut Dysbiosis: A Driver of Later-Life Fibrosis?. J Invest Dermatol. 2017;137:2253-2255 pubmed publisher

More Information


  1. Borgo F, Riva A, Benetti A, Casiraghi M, Bertelli S, Garbossa S, et al. Microbiota in anorexia nervosa: The triangle between bacterial species, metabolites and psychological tests. PLoS ONE. 2017;12:e0179739 pubmed publisher
    ..BMI represented the best predictive value for gut dysbiosis and metabolic alterations, showing a negative correlation with Bacteroides uniformis (microbiota), with alanine ..
  2. Stedtfeld R, Stedtfeld T, Fader K, Williams M, Bhaduri P, Quensen J, et al. TCDD influences reservoir of antibiotic resistance genes in murine gut microbiome. FEMS Microbiol Ecol. 2017;93: pubmed publisher
    b>Dysbiosis of the gut microbiome via antibiotics, changes in diet and infection can select for bacterial groups that more frequently harbor antimicrobial resistance genes (ARGs) and mobile genetic elements (MGEs)...
  3. Chitrala K, Guan H, Singh N, Busbee B, Gandy A, Mehrpouya Bahrami P, et al. CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice. Eur J Immunol. 2017;47:1188-1199 pubmed publisher
    b>Dysbiosis in gut microbiome has been shown to be associated with inflammatory and autoimmune diseases...
  4. Floudas A, Saunders S, Moran T, Schwartz C, Hams E, Fitzgerald D, et al. IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation. J Immunol. 2017;199:707-717 pubmed publisher
    ..Skin microbiome dysbiosis developed in the absence of IL-17RA, with antibiotic intervention resulting in significant amelioration of skin ..
  5. Breban M, Tap J, Leboime A, Said Nahal R, Langella P, Chiocchia G, et al. Faecal microbiota study reveals specific dysbiosis in spondyloarthritis. Ann Rheum Dis. 2017;76:1614-1622 pubmed publisher
    Altered microbiota composition or dysbiosis is suspected to be implicated in the pathogenesis of chronic inflammatory diseases, such as spondyloarthritis (SpA) and rheumatoid arthritis (RA)...
  6. Botschuijver S, Roeselers G, Levin E, Jonkers D, Welting O, Heinsbroek S, et al. Intestinal Fungal Dysbiosis Is Associated With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats. Gastroenterology. 2017;153:1026-1039 pubmed publisher
    Visceral hypersensitivity is one feature of irritable bowel syndrome (IBS). Bacterial dysbiosis might be involved in the activation of nociceptive sensory pathways, but there have been few studies of the role of the mycobiome (the fungal ..
  7. Thursby E, Juge N. Introduction to the human gut microbiota. Biochem J. 2017;474:1823-1836 pubmed publisher
    ..Altered gut bacterial composition (dysbiosis) has been associated with the pathogenesis of many inflammatory diseases and infections...
  8. Chen J, Huang C, Wang J, Zhou H, Lu Y, Lou L, et al. Dysbiosis of intestinal microbiota and decrease in paneth cell antimicrobial peptide level during acute necrotizing pancreatitis in rats. PLoS ONE. 2017;12:e0176583 pubmed publisher
    ..barrier dysfunction plays an important role in acute necrotizing pancreatitis (ANP) and intestinal microbiota dysbiosis was involved in intestinal barrier failure...
  9. Thevaranjan N, Puchta A, Schulz C, Naidoo A, Szamosi J, Verschoor C, et al. Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction. Cell Host Microbe. 2017;21:455-466.e4 pubmed publisher
    ..These data suggest that aging-associated microbiota promote inflammation and that reversing these age-related microbiota changes represents a potential strategy for reducing age-associated inflammation and the accompanying morbidity. ..
  10. Chung K. Airway microbial dysbiosis in asthmatic patients: A target for prevention and treatment?. J Allergy Clin Immunol. 2017;139:1071-1081 pubmed publisher
    ..A better understanding of the regulation of both the lung and gut microbiota to derive appropriate targets for prevention or treatment of asthma is needed. ..
  11. Zhang S, Cao X, Huang H. Sampling Strategies for Three-Dimensional Spatial Community Structures in IBD Microbiota Research. Front Cell Infect Microbiol. 2017;7:51 pubmed publisher
    ..On the basis of this spatial model, this article also summarizes various sampling and processing strategies prior to and after DNA extraction and recommends guidelines for practical application in future research. ..
  12. Liu R, Hong J, Xu X, Feng Q, Zhang D, Gu Y, et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nat Med. 2017;23:859-868 pubmed publisher
    ..Our findings identify previously unknown links between intestinal microbiota alterations, circulating amino acids and obesity, suggesting that it may be possible to intervene in obesity by targeting the gut microbiota. ..
  13. Bhatt A, Redinbo M, Bultman S. The role of the microbiome in cancer development and therapy. CA Cancer J Clin. 2017;67:326-344 pubmed publisher
    ..Even larger numbers of malignancies are associated with an altered composition of commensal microbiota (dysbiosis) based on microbiome studies using metagenomic sequencing...
  14. Mizock B. Probiotics. Dis Mon. 2015;61:259-90 pubmed publisher
  15. Ni J, Wu G, Albenberg L, Tomov V. Gut microbiota and IBD: causation or correlation?. Nat Rev Gastroenterol Hepatol. 2017;14:573-584 pubmed publisher
    ..consensus exists that IBD is associated with compositional and metabolic changes in the intestinal microbiota (dysbiosis)...
  16. Brown R, Marchesi J, Lee Y, Smith A, Lehne B, Kindinger L, et al. Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin. BMC Med. 2018;16:9 pubmed publisher
    ..In contrast to pregnancies delivering at term, vaginal dysbiosis characterised by Lactobacillus spp...
  17. Hall A, Tolonen A, Xavier R. Human genetic variation and the gut microbiome in disease. Nat Rev Genet. 2017;18:690-699 pubmed publisher
    ..findings support the hypothesis that certain host genetic variants predispose an individual towards microbiome dysbiosis. This condition, in which the normal microbiome population structure is disturbed, is a key feature in disorders ..
  18. Fawley J, Koehler S, Cabrera S, Lam V, Fredrich K, Hessner M, et al. Intestinal alkaline phosphatase deficiency leads to dysbiosis and bacterial translocation in the newborn intestine. J Surg Res. 2017;218:35-42 pubmed publisher
    ..We hypothesize that the absence of IAP leads to dysbiosis, with increased inflammation and permeability of the newborn intestine.
  19. Wu S, Cao Z, Chang K, Juang J. Intestinal microbial dysbiosis aggravates the progression of Alzheimer's disease in Drosophila. Nat Commun. 2017;8:24 pubmed publisher
    ..However, inflammation in the brain is not always a response to local primary insults. Gut microbiota dysbiosis, which is recently emerging as a risk factor for psychiatric disorders, can also initiate a brain inflammatory ..
  20. Wu B, Segal L. Lung Microbiota and Its Impact on the Mucosal Immune Phenotype. Microbiol Spectr. 2017;5: pubmed publisher
    ..on the possible inflammatory pathways that are up- and downregulated when the immune system is challenged by dysbiosis. Identification of potential markers and microbial targets to address the modulation of inflammation in early ..
  21. Van Raay T, Allen Vercoe E. Microbial Interactions and Interventions in Colorectal Cancer. Microbiol Spectr. 2017;5: pubmed publisher
    ..In this review, we discuss several leading theories that connect gut microbial dysbiosis with CRC and set this against a backdrop of what is known about proximal-distal gut physiology and the pathways ..
  22. Shen P, Whelan F, Schenck L, McGrath J, Vanderstocken G, Bowdish D, et al. Streptococcus pneumoniae Colonization Is Required To Alter the Nasal Microbiota in Cigarette Smoke-Exposed Mice. Infect Immun. 2017;85: pubmed publisher
    Smokers have nasal microbiota dysbiosis, with an increased frequency of colonizing bacterial pathogens...
  23. Richards E, Pepine C, Raizada M, Kim S. The Gut, Its Microbiome, and Hypertension. Curr Hypertens Rep. 2017;19:36 pubmed publisher
    Evidence is rapidly accumulating implicating gut dysbiosis in hypertension (HTN)...
  24. Barash N, Maloney J, Singer S, Dawson S. Giardia Alters Commensal Microbial Diversity throughout the Murine Gut. Infect Immun. 2017;85: pubmed publisher
    ..with Giardia We discovered that Giardia's colonization of the small intestine causes a systemic dysbiosis of aerobic and anaerobic commensal bacteria...
  25. Venema K. Foreword--there is still tremendous interest in probiotics and prebiotics. Benef Microbes. 2015;6:1-2 pubmed publisher
  26. Glendinning L, Free A. Supra-organismal interactions in the human intestine. Front Cell Infect Microbiol. 2014;4:47 pubmed publisher
  27. Mariño E, Richards J, McLeod K, Stanley D, Yap Y, Knight J, et al. Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nat Immunol. 2017;18:552-562 pubmed publisher
    Gut dysbiosis might underlie the pathogenesis of type 1 diabetes...
  28. Meyle J, Chapple I. Molecular aspects of the pathogenesis of periodontitis. Periodontol 2000. 2015;69:7-17 pubmed publisher
    ..in the local environment, which may include inflammatory response mediators or viruses, conspire to drive dysbiosis and create a biofilm that supports pathogenic species capable of propagating disease...
  29. Brooks J, Watson A. The Enteric Virome in Inflammatory Bowel Disease. Gastroenterology. 2015;149:1120-1 pubmed publisher
  30. Hill Burns E, Debelius J, Morton J, Wissemann W, Lewis M, Wallen Z, et al. Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome. Mov Disord. 2017;32:739-749 pubmed publisher
    There is mounting evidence for a connection between the gut and Parkinson's disease (PD). Dysbiosis of gut microbiota could explain several features of PD...
  31. Perez H, Menezes M, D Acampora A. [Intestinal microbiota]. Acta Gastroenterol Latinoam. 2014;44:265-72 pubmed
    ..There are few studies on the spatial distribution of the microflora in the gut. Unravelling the topography of the microflora in mammals is a way to validate new animal models for the study of microflora. ..
  32. Sommer F, Anderson J, Bharti R, Raes J, Rosenstiel P. The resilience of the intestinal microbiota influences health and disease. Nat Rev Microbiol. 2017;15:630-638 pubmed publisher
    ..The resilience of the healthy microbiota protects us from dysbiosis-related diseases, such as inflammatory bowel disease (IBD) or metabolic disorder...
  33. Chong Nguyen C, Duboc H, Sokol H. [The gut microbiota, a new cardiovascular risk factor?]. Presse Med. 2017;46:708-713 pubmed publisher
    ..The disturbance in the metabolism and the composition of the gut microbiota is called "dysbiosis"...
  34. Salzman N. The role of the microbiome in immune cell development. Ann Allergy Asthma Immunol. 2014;113:593-8 pubmed publisher
  35. Barve S, Kirpich I, McClain C. Tumor necrosis factor alpha-induced receptor 1 signaling in alcoholic liver disease: A gut reaction?. Hepatology. 2015;61:754-6 pubmed publisher
  36. Mamantopoulos M, Ronchi F, Van Hauwermeiren F, Vieira Silva S, Yilmaz B, Martens L, et al. Nlrp6- and ASC-Dependent Inflammasomes Do Not Shape the Commensal Gut Microbiota Composition. Immunity. 2017;47:339-348.e4 pubmed publisher
    ..This notion stems from studies reporting dysbiosis in mice lacking these inflammasome components when compared with non-littermate wild-type animals...
  37. Brandl K, Schnabl B. Intestinal microbiota and nonalcoholic steatohepatitis. Curr Opin Gastroenterol. 2017;33:128-133 pubmed publisher
    ..NASH pathogenesis is multifactorial including genetic and environmental factors. The gut microbiota is involved in disease progression and its role is complex...
  38. Jorth P, Turner K, Gumus P, Nizam N, Buduneli N, Whiteley M. Metatranscriptomics of the human oral microbiome during health and disease. MBio. 2014;5:e01012-14 pubmed publisher
    ..Furthermore, disease-associated communities exhibit conserved changes in metabolic and virulence gene expression. ..
  39. Goulas T, Ksiazek M, Garcia Ferrer I, Sochaj Gregorczyk A, Waligorska I, Wasylewski M, et al. A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome. J Biol Chem. 2017;292:10883-10898 pubmed publisher
    ..This finding suggests that miropin was acquired from the host through horizontal gene transfer, perhaps facilitated by the long and intimate association of T. forsythia with the human gingiva. ..
  40. Gao B, Vorwerk H, Huber C, Lara Tejero M, Mohr J, Goodman A, et al. Metabolic and fitness determinants for in vitro growth and intestinal colonization of the bacterial pathogen Campylobacter jejuni. PLoS Biol. 2017;15:e2001390 pubmed publisher
    ..This comprehensive analysis has identified metabolic pathways that could provide the basis for the development of novel strategies to prevent C. jejuni colonization of food-producing animals or to treat human infections. ..
  41. Poulsen A, de Jonge N, Sugiharto S, Nielsen J, Lauridsen C, Canibe N. The microbial community of the gut differs between piglets fed sow milk, milk replacer or bovine colostrum. Br J Nutr. 2017;117:964-978 pubmed publisher
    ..The results indicate that BC may be a useful substitute for regular milk replacers, and as a feeding supplement in the immediate post-weaning period...
  42. Mezzelani A, Landini M, Facchiano F, Raggi M, Villa L, Molteni M, et al. Environment, dysbiosis, immunity and sex-specific susceptibility: a translational hypothesis for regressive autism pathogenesis. Nutr Neurosci. 2015;18:145-61 pubmed publisher
    ..an immune vulnerability to infection diseases that, especially if treated with antibiotics, could facilitate dysbiosis and GI disorders...
  43. Seekatz A, Young V. Clostridium difficile and the microbiota. J Clin Invest. 2014;124:4182-9 pubmed publisher
    ..These findings will improve current biotherapeutics for patients with CDI, particularly those with recurrent disease. ..
  44. Dalal S, Chang E. The microbial basis of inflammatory bowel diseases. J Clin Invest. 2014;124:4190-6 pubmed publisher
  45. Mehta H, Goulet P, Mashiko S, Desjardins J, Perez G, Koenig M, et al. Early-Life Antibiotic Exposure Causes Intestinal Dysbiosis and Exacerbates Skin and Lung Pathology in Experimental Systemic Sclerosis. J Invest Dermatol. 2017;137:2316-2325 pubmed publisher
    ..Patients with systemic sclerosis (SSc) display altered intestinal microbiota. However, the influence of intestinal dysbiosis on the development of experimental SSc remains unknown...
  46. Bednarska O, Walter S, Casado Bedmar M, Ström M, Salvo Romero E, Vicario M, et al. Vasoactive Intestinal Polypeptide and Mast Cells Regulate Increased Passage of Colonic Bacteria in Patients With Irritable Bowel Syndrome. Gastroenterology. 2017;153:948-960.e3 pubmed publisher
    Irritable bowel syndrome (IBS) is associated with intestinal dysbiosis and symptoms of IBS develop following gastroenteritis...
  47. Zhang C, Yin A, Li H, Wang R, Wu G, Shen J, et al. Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children. EBioMedicine. 2015;2:968-84 pubmed publisher
    ..We found that children genetically obese with Prader-Willi syndrome shared a similar dysbiosis in their gut microbiota with those having diet-related obesity...
  48. Nicolas S, Blasco Baque V, Fournel A, Gilleron J, Klopp P, Waget A, et al. Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism. Mol Syst Biol. 2017;13:921 pubmed publisher
    Gut microbiota dysbiosis has been implicated in a variety of systemic disorders, notably metabolic diseases including obesity and impaired liver function, but the underlying mechanisms are uncertain...
  49. Iliev I, Leonardi I. Fungal dysbiosis: immunity and interactions at mucosal barriers. Nat Rev Immunol. 2017;17:635-646 pubmed publisher
    ..Studies focused on commensal bacteria suggest that pathological changes in the microbiota, historically known as dysbiosis, are at the root of many inflammatory diseases of non-infectious origin...
  50. Hardy L, Jespers V, De Baetselier I, Buyze J, Mwambarangwe L, Musengamana V, et al. Association of vaginal dysbiosis and biofilm with contraceptive vaginal ring biomass in African women. PLoS ONE. 2017;12:e0178324 pubmed publisher
    ..We found a correlation between vaginal dysbiosis and the density and composition of the ring biomass, and further research is needed to determine if these ..
  51. de Oliveira G, Leite A, Higuchi B, Gonzaga M, Mariano V. Intestinal dysbiosis and probiotic applications in autoimmune diseases. Immunology. 2017;152:1-12 pubmed publisher
    ..However, the exact mechanisms involved in the dysbiosis and breakdown of the gut epithelial barrier are currently unknown...