delayed graft function

Summary

Summary: General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.

Top Publications

  1. Schroppel B, Krüger B, Walsh L, Yeung M, Harris S, Garrison K, et al. Tubular expression of KIM-1 does not predict delayed function after transplantation. J Am Soc Nephrol. 2010;21:536-42 pubmed publisher
    ..It is unknown whether KIM-1 expression changes in kidney allografts with delayed graft function (DGF), which often follows ischemia-reperfusion injury...
  2. Hall I, Doshi M, Poggio E, Parikh C. A comparison of alternative serum biomarkers with creatinine for predicting allograft function after kidney transplantation. Transplantation. 2011;91:48-56 pubmed publisher
    ..Among 78 recipients with serum biomarker measurements, 26 had delayed graft function (DGF; hemodialysis within 1 week of transplant)...
  3. van der Vliet J, Warlé M, Cheung C, Teerenstra S, Hoitsma A. Influence of prolonged cold ischemia in renal transplantation. Clin Transplant. 2011;25:E612-6 pubmed publisher
    ..Mean CIT was 24.0 ± 7.9 h in HBD and 21.6 ± 6.7 h in DCD. The percentage delayed graft function (DGF) was 12.3 and 50.4, respectively (p < 0.001)...
  4. Cavaille Coll M, Bala S, Velidedeoglu E, Hernandez A, Archdeacon P, Gonzalez G, et al. Summary of FDA workshop on ischemia reperfusion injury in kidney transplantation. Am J Transplant. 2013;13:1134-48 pubmed publisher
    ..Topics included the development of IRI and delayed graft function (DGF), histology and biomarkers, donor factors, recipient factors, organ quality and organ preservation by ..
  5. van Gelder T, Silva H, de Fijter H, Budde K, Kuypers D, Mamelok R, et al. How delayed graft function impacts exposure to mycophenolic acid in patients after renal transplantation. Ther Drug Monit. 2011;33:155-64 pubmed publisher
    ..Patients with delayed graft function (DGF) after renal transplantation are exposed to low total MPA concentrations, when risk of rejection is ..
  6. Doshi M, Garg N, REESE P, Parikh C. Recipient risk factors associated with delayed graft function: a paired kidney analysis. Transplantation. 2011;91:666-71 pubmed publisher
    b>Delayed graft function (DGF) is a common complication of deceased donor kidney transplantation that occurs because of a complex interplay between donor organ quality and the biologic milieu of the recipient...
  7. Vilar E, Varagunam M, Yaqoob M, Raftery M, Thuraisingham R. Creatinine reduction ratio: a useful marker to identify medium and high-risk renal transplants. Transplantation. 2010;89:97-103 pubmed publisher
    b>Delayed graft function (DGF) has a major impact on long-term renal transplant survival. However, it is a diagnosis made retrospectively with little opportunity to modify treatment protocols...
  8. Dikow R, Becker L, Schaier M, Waldherr R, Gross M, Zeier M. In renal transplants with delayed graft function chemokines and chemokine receptor expression predict long-term allograft function. Transplantation. 2010;90:771-6 pubmed publisher
    ..We studied the role of chemokines in kidney allografts with delayed graft function and the subsequent long-term outcome of renal function and fibrosis...
  9. Hall I, Yarlagadda S, Coca S, Wang Z, Doshi M, Devarajan P, et al. IL-18 and urinary NGAL predict dialysis and graft recovery after kidney transplantation. J Am Soc Nephrol. 2010;21:189-97 pubmed publisher
    ..We classified graft recovery as delayed graft function (DGF), slow graft function (SGF), or immediate graft function (IGF)...

More Information

Publications62

  1. Li C, Yang C. The pathogenesis and treatment of chronic allograft nephropathy. Nat Rev Nephrol. 2009;5:513-9 pubmed publisher
    ..The prevention and treatment of CAN needs multidisciplinary strategies. Early detection by means of protocol biopsy and calculation of glomerular filtration rate is the first step, followed by management of modifiable risk factors. ..
  2. Robert R, Guilhot J, Pinsard M, Longeard P, Jacob J, Gissot V, et al. A pair analysis of the delayed graft function in kidney recipient: the critical role of the donor. J Crit Care. 2010;25:582-90 pubmed publisher
    ..the importance of donor factors and especially the potential role of hemodynamic management in regard to delayed graft function in paired kidney recipient patients after renal transplantation and to analyze the urine of organ donors ..
  3. Abboud I, Antoine C, Gaudez F, Fieux F, Lefaucheur C, Pillebout E, et al. Pulsatile perfusion preservation for expanded-criteria donors kidneys: Impact on delayed graft function rate. Int J Artif Organs. 2011;34:513-8 pubmed publisher
    Expanded criteria donors (ECD) kidneys are a potential solution to organ shortage, but exhibit more delayed graft function (DGF)...
  4. Mas V, Scian M, Archer K, Suh J, David K, Ren Q, et al. Pretransplant transcriptome profiles identify among kidneys with delayed graft function those with poorer quality and outcome. Mol Med. 2011;17:1311-22 pubmed publisher
    ..The occurrence of delayed graft function (DGF) is most often used as a clinical outcome marker to capture poor kidney quality...
  5. Siedlecki A, Irish W, Brennan D. Delayed graft function in the kidney transplant. Am J Transplant. 2011;11:2279-96 pubmed publisher
    ..injury occurs with kidney transplantation and too frequently progresses to the clinical diagnosis of delayed graft function (DGF)...
  6. Nagaraja P, Roberts G, Stephens M, Horváth S, Fialova J, Chavez R, et al. Influence of delayed graft function and acute rejection on outcomes after kidney transplantation from donors after cardiac death. Transplantation. 2012;94:1218-23 pubmed publisher
    b>Delayed graft function (DGF) and acute rejection (AR) exert an adverse impact on graft outcomes after kidney transplantation using organs from donation after brain-stem death (DBD) donors...
  7. Hanto D, Maki T, Yoon M, Csizmadia E, Chin B, Gallo D, et al. Intraoperative administration of inhaled carbon monoxide reduces delayed graft function in kidney allografts in Swine. Am J Transplant. 2010;10:2421-30 pubmed publisher
    Ischemia/reperfusion injury and delayed graft function (DGF) following organ transplantation adversely affect graft function and survival. A large animal model has not been characterized...
  8. Elens L, Bouamar R, Hesselink D, Haufroid V, van Gelder T, van Schaik R. The new CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with an increased risk of delayed graft function and worse renal function in cyclosporine-treated kidney transplant patients. Pharmacogenet Genomics. 2012;22:373-80 pubmed publisher
    ..Plasma creatinine concentrations, delayed graft function (DGF), and biopsy-proven acute rejection were recorded...
  9. Dołęgowska B, Błogowski W, Domanski L. Dynamics of thromboxane level changes during early phase of allograft reperfusion. Clin Transplant. 2009;23:716-22 pubmed publisher
    ..Sixty-nine transplant recipients were divided into early, slow and delayed graft function group...
  10. Garonzik Wang J, Govindan P, Grinnan J, Liu M, Ali H, Chakraborty A, et al. Frailty and delayed graft function in kidney transplant recipients. Arch Surg. 2012;147:190-3 pubmed publisher
    ..We hypothesized that frailty would be associated with delayed graft function, based on putative associations between inflammatory cytokines and graft dysfunction...
  11. Loverre A, Divella C, Castellano G, Tataranni T, Zaza G, Rossini M, et al. T helper 1, 2 and 17 cell subsets in renal transplant patients with delayed graft function. Transpl Int. 2011;24:233-42 pubmed publisher
    Ischemia-reperfusion injury (IRI) in kidney transplantation is the major cause of delayed graft function (DGF), an event associated with an increased risk of acute rejection...
  12. Welberry Smith M, Zougman A, Cairns D, Wilson M, Wind T, Wood S, et al. Serum aminoacylase-1 is a novel biomarker with potential prognostic utility for long-term outcome in patients with delayed graft function following renal transplantation. Kidney Int. 2013;84:1214-25 pubmed publisher
    Early identification and prognostic stratification of delayed graft function following renal transplantation has significant potential to improve outcome...
  13. Mühlberger I, Perco P, Fechete R, Mayer B, Oberbauer R. Biomarkers in renal transplantation ischemia reperfusion injury. Transplantation. 2009;88:S14-9 pubmed publisher
    Ischemia reperfusion injury (IRI) is a choreographed process leading to delayed graft function (DGF) and reduced long-term patency of the transplanted organ...
  14. Cheung C, Chan H, Chan Y, Chau K, Li C. Impact of delayed graft function on renal function and graft survival in deceased kidney transplantation. Hong Kong Med J. 2010;16:378-82 pubmed
    To define the risk factors for delayed graft function and study the impact of such delays on renal function and long-term allograft survival in renal transplant recipients. Single-centre retrospective study. Regional hospital, Hong Kong...
  15. Shah A, Milgrom D, Mangus R, Powelson J, Goggins W, Milgrom M. Comparison of pulsatile perfusion and cold storage for paired kidney allografts. Transplantation. 2008;86:1006-9 pubmed publisher
    ..Study outcomes included 1-year graft and patient survival, delayed graft function, and need for posttransplant dialysis. Recipients had similar demographic and disease characteristics...
  16. Treckmann J, Moers C, Smits J, Gallinat A, Maathuis M, van Kasterop Kutz M, et al. Machine perfusion versus cold storage for preservation of kidneys from expanded criteria donors after brain death. Transpl Int. 2011;24:548-54 pubmed publisher
    ..of this study was to analyze the possible effects of machine perfusion (MP) versus cold storage (CS) on delayed graft function (DGF) and early graft survival in expanded criteria donor kidneys (ECD)...
  17. Kotsch K, Kunert K, Merk V, Reutzel Selke A, Pascher A, Fritzsche F, et al. Novel markers in zero-hour kidney biopsies indicate graft quality and clinical outcome. Transplantation. 2010;90:958-65 pubmed publisher
    ..tested for posttransplantation clinical outcomes showing the potential to predict the development of delayed graft function, acute rejection, and renal function after 6 months...
  18. Mallon D, Summers D, Bradley J, Pettigrew G. Defining delayed graft function after renal transplantation: simplest is best. Transplantation. 2013;96:885-9 pubmed publisher
    b>Delayed graft function (DGF) after renal transplantation can be diagnosed according to several different definitions, complicating comparison between studies that use DGF as an endpoint...
  19. Tedesco Silva H, Lorber M, Foster C, Sollinger H, Mendez R, Carvalho D, et al. FTY720 and everolimus in de novo renal transplant patients at risk for delayed graft function: results of an exploratory one-yr multicenter study. Clin Transplant. 2009;23:589-99 pubmed publisher
    ..in combination with everolimus and steroids in de novo renal transplant recipients at increased risk of delayed graft function (DGF). Patients received FTY720 (5 mg) and everolimus (4 mg) 2-12 h pre-transplantation, followed by 2...
  20. Akkina S, Connaire J, Israni A, Snyder J, Matas A, Kasiske B. Similar outcomes with different rates of delayed graft function may reflect center practice, not center performance. Am J Transplant. 2009;9:1460-6 pubmed publisher
    To better understand the implications for considering delayed graft function (DGF) as a performance measure, we compared outcomes associated with a 2- to 3-fold difference in the incidence of DGF at two transplant centers...
  21. Jayaram D, Kommareddi M, Sung R, Luan F. Delayed graft function requiring more than one-time dialysis treatment is associated with inferior clinical outcomes. Clin Transplant. 2012;26:E536-43 pubmed publisher
    b>Delayed graft function (DGF) is a common complication of deceased donor kidney transplantation with negative impact on clinical outcomes...
  22. Dołęgowska B, Błogowski W, Domanski L. Clinical evidence of the association between serum perioperative changes in xanthine metabolizing enzymes activity and early post-transplant kidney allograft function. J Am Coll Surg. 2010;211:587-95 pubmed publisher
    ..enzymes (XME) activity in kidney transplant recipients divided into early (EGF), slow (SGF), and delayed graft function (DGF) groups...
  23. Tapiawala S, Tinckam K, Cardella C, Schiff J, Cattran D, Cole E, et al. Delayed graft function and the risk for death with a functioning graft. J Am Soc Nephrol. 2010;21:153-61 pubmed publisher
    b>Delayed graft function (DGF) associates with an increased risk for graft failure, but its link with death with graft function (DWGF) is unknown...
  24. Narayanan R, Cardella C, Cattran D, Cole E, Tinckam K, Schiff J, et al. Delayed graft function and the risk of death with graft function in living donor kidney transplant recipients. Am J Kidney Dis. 2010;56:961-70 pubmed publisher
    The link between delayed graft function (DGF) and death with graft function (DWGF) in living donor kidney transplant recipients presently is unknown. Retrospective cohort study...
  25. Requião Moura L, Ferraz E, Matos A, Tonato E, Ozaki K, Durao M, et al. Comparison of long-term effect of thymoglobulin treatment in patients with a high risk of delayed graft function. Transplant Proc. 2012;44:2428-33 pubmed publisher
    ..injury (IRI) in progression to chronic allograft dysfunction, especially among patients at high risk for delayed graft function (DGF)...
  26. Grzelak P, Szymczyk K, Strzelczyk J, Kurnatowska I, Sapieha M, Nowicki M, et al. Perfusion of kidney graft pyramids and cortex in contrast-enhanced ultrasonography in the determination of the cause of delayed graft function. Ann Transplant. 2011;16:48-53 pubmed
    ..good early graft function (EGF) and acute rejection (AR) or acute tubular necrosis (ATN) as a cause of delayed graft function (DGF)...
  27. Martinez F, Kamar N, Pallet N, Lang P, Durrbach A, Lebranchu Y, et al. High dose epoetin beta in the first weeks following renal transplantation and delayed graft function: Results of the Neo-PDGF Study. Am J Transplant. 2010;10:1695-700 pubmed publisher
    ..Neorecormon and Prevention of Delayed Graft Function (Neo-PDGF) is a French open-label multicenter randomized study to evaluate the effect of high doses of ..
  28. Chapal M, Néel M, Le Borgne F, Meffray E, Carceles O, Hourmant M, et al. Increased soluble Flt-1 correlates with delayed graft function and early loss of peritubular capillaries in the kidney graft. Transplantation. 2013;96:739-44 pubmed publisher
    Ischemia-reperfusion induces tubular and endothelial damage in the renal graft and leads to delayed graft function (DGF) and to an early loss of peritubular capillaries (PTC)...
  29. Moers C, Smits J, Maathuis M, Treckmann J, Van Gelder F, Napieralski B, et al. Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med. 2009;360:7-19 pubmed publisher
    ..All 672 recipients were followed for 1 year. The primary end point was delayed graft function (requiring dialysis in the first week after transplantation)...
  30. Lee E, Kim M, Park Y, Kim H. Serum neutrophil gelatinase-associated lipocalin and interleukin-18 as predictive biomarkers for delayed graft function after kidney transplantation. J Clin Lab Anal. 2012;26:295-301 pubmed publisher
    Early biomarkers for acute kidney injury after kidney transplantation have been studied because delayed graft function (DGF) is associated with increased risk of acute rejection and graft loss...
  31. Halawa A. The early diagnosis of acute renal graft dysfunction: a challenge we face. The role of novel biomarkers. Ann Transplant. 2011;16:90-8 pubmed
    ..Most of these biomarkers were developed in non-transplant AKI, yet their role in clinical transplantation has to be identified. ..
  32. Zhao H, Watts H, Chong M, Huang H, Tralau Stewart C, Maxwell P, et al. Xenon treatment protects against cold ischemia associated delayed graft function and prolongs graft survival in rats. Am J Transplant. 2013;13:2006-18 pubmed publisher
    ..injury (IRI) in the renal graft, which is considered to contribute to the occurrence of the delayed graft function (DGF) and chronic graft failure...
  33. Sharif A, Borrows R. Delayed graft function after kidney transplantation: the clinical perspective. Am J Kidney Dis. 2013;62:150-8 pubmed publisher
    b>Delayed graft function continues to pose a significant challenge to clinicians in the context of kidney transplantation...
  34. Keller A, Jørgensen T, Vittrup D, Kjerkegaard U, Jespersen B, Krag S, et al. Fast detection of renal ischemia in transplanted kidneys with delayed graft function-an experimental study. Transplantation. 2013;95:275-9 pubmed publisher
    ..kidney is difficult to monitor with regard to postoperative vascular thrombosis, especially when there is delayed graft function. We evaluated microdialysis as a tool for early ischemia detection in porcine kidneys with delayed graft ..
  35. Hollmen M, Kyllönen L, Inkinen K, Lalla M, Salmela K. Urine neutrophil gelatinase-associated lipocalin is a marker of graft recovery after kidney transplantation. Kidney Int. 2011;79:89-98 pubmed publisher
    b>Delayed graft function (DGF), especially long-lasting DGF, complicates kidney transplant outcome...
  36. Jochmans I, Moers C, Smits J, Leuvenink H, Treckmann J, Paul A, et al. Machine perfusion versus cold storage for the preservation of kidneys donated after cardiac death: a multicenter, randomized, controlled trial. Ann Surg. 2010;252:756-64 pubmed publisher
    ..Primary endpoint was delayed graft function (DGF), defined as dialysis requirement in the first week after transplantation...
  37. Irish W, Ilsley J, Schnitzler M, Feng S, Brennan D. A risk prediction model for delayed graft function in the current era of deceased donor renal transplantation. Am J Transplant. 2010;10:2279-86 pubmed publisher
    b>Delayed graft function (DGF) impacts short- and long-term outcomes. We present a model for predicting DGF after renal transplantation...
  38. Singh R, Farney A, Rogers J, Zuckerman J, Reeves Daniel A, Hartmann E, et al. Kidney transplantation from donation after cardiac death donors: lack of impact of delayed graft function on post-transplant outcomes. Clin Transplant. 2011;25:255-64 pubmed publisher
    b>Delayed graft function (DGF) is more common in recipients of kidney transplants from donation after cardiac death (DCD) donors compared to donation after brain death (DBD) donors...
  39. Parekh J, Bostrom A, Feng S. Diabetes mellitus: a risk factor for delayed graft function after deceased donor kidney transplantation. Am J Transplant. 2010;10:298-303 pubmed publisher
    ..elevated peak panel reactive antibody and increased cold ischemia time were independent risk factors for delayed graft function. Specifically, diabetic recipients had increased risk of DGF on univariate analysis (odds ratio [OR] 1...
  40. Dołęgowska B, Błogowski W, Domanski L. Is it possible to predict the early post-transplant allograft function using 20-HETE measurements? A preliminary report. Transpl Int. 2009;22:546-53 pubmed publisher
    ..Sixty-nine renal transplant recipients were divided, according to their outcome, into early, slow and delayed graft function (EGF, SGF, DGF) group...
  41. Yarlagadda S, Coca S, Formica R, Poggio E, Parikh C. Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis. Nephrol Dial Transplant. 2009;24:1039-47 pubmed publisher
    b>Delayed graft function (DGF) is a common complication of renal transplantation...
  42. Hollmen M, Kyllönen L, Inkinen K, Lalla M, Merenmies J, Salmela K. Deceased donor neutrophil gelatinase-associated lipocalin and delayed graft function after kidney transplantation: a prospective study. Crit Care. 2011;15:R121 pubmed publisher
    Expanding the criteria for deceased organ donors increases the risk of delayed graft function (DGF) and complicates kidney transplant outcome...
  43. Nogueira J, Haririan A, Jacobs S, Weir M, Hurley H, Al Qudah H, et al. The detrimental effect of poor early graft function after laparoscopic live donor nephrectomy on graft outcomes. Am J Transplant. 2009;9:337-47 pubmed publisher
    ..Poor EGF was defined as receiving hemodialysis on postoperative day (POD) 1 through POD 7 (delayed graft function [DGF]) or serum creatinine >/= 3...
  44. Johnston O, O Kelly P, Spencer S, Donohoe J, Walshe J, Little D, et al. Reduced graft function (with or without dialysis) vs immediate graft function--a comparison of long-term renal allograft survival. Nephrol Dial Transplant. 2006;21:2270-4 pubmed
    b>Delayed graft function (DGF) is a common complication in cadaveric kidney transplants affecting graft outcome. However, the incidence of DGF differs widely between centres as its definition is very variable...
  45. Parikh C, Jani A, Mishra J, Ma Q, Kelly C, Barasch J, et al. Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation. Am J Transplant. 2006;6:1639-45 pubmed
    b>Delayed graft function (DGF) due to tubule cell injury frequently complicates deceased donor kidney transplants...
  46. Loverre A, Capobianco C, Ditonno P, Battaglia M, Grandaliano G, Schena F. Increase of proliferating renal progenitor cells in acute tubular necrosis underlying delayed graft function. Transplantation. 2008;85:1112-9 pubmed publisher
    b>Delayed graft function (DGF) is associated with acute tubular necrosis. In this setting, surviving tubular cells may proliferate and replace injured cells. CD133Pax-2cells may play a role in the regeneration of tubular damage...
  47. Ogliari A, Caldara R, Socci C, Sordi V, Cagni N, Moretti M, et al. High levels of donor CCL2/MCP-1 predict graft-related complications and poor graft survival after kidney-pancreas transplantation. Am J Transplant. 2008;8:1303-11 pubmed publisher
    ..This suggests that the severity of the inflammatory response induced by brain death influences the posttransplant inflammatory response, independent of subsequent ischemia and reperfusion...
  48. Lauzurica R, Pastor M, Bayes B, Hernandez J, Bonet J, Doladé M, et al. Pretransplant inflammation: a risk factor for delayed graft function?. J Nephrol. 2008;21:221-8 pubmed
    ..that transplant recipients with pretransplant inflammation may have a greater chance of developing delayed graft function (DGF), an example of IAKI...
  49. Patel S, DUHART B, Krauss A, Moore L, Egidi M, Amiri H, et al. Risk factors and consequences of delayed graft function in deceased donor renal transplant patients receiving antithymocyte globulin induction. Transplantation. 2008;86:313-20 pubmed publisher
    Induction rabbit antithymocyte globulin (rATG) is largely used in renal allograft recipients at risk for delayed graft function (DGF) and immunologic rejection...
  50. Kusaka M, Kuroyanagi Y, Mori T, Nagaoka K, Sasaki H, Maruyama T, et al. Serum neutrophil gelatinase-associated lipocalin as a predictor of organ recovery from delayed graft function after kidney transplantation from donors after cardiac death. Cell Transplant. 2008;17:129-34 pubmed
    ..However, DCD kidneys often have complications with delayed graft function (DGF) and recipients require hemodialysis (HD) in the early period after kidney transplantation (KTx)...
  51. Pratschke J, Weiss S, Neuhaus P, Pascher A. Review of nonimmunological causes for deteriorated graft function and graft loss after transplantation. Transpl Int. 2008;21:512-22 pubmed publisher
    ..We review nonimmunological causes for deteriorated graft function and graft loss after solid organ transplantation. ..
  52. Aquino Dias E, Joelsons G, Da Silva D, Berdichevski R, Berdichewski R, Ribeiro A, et al. Non-invasive diagnosis of acute rejection in kidney transplants with delayed graft function. Kidney Int. 2008;73:877-84 pubmed publisher
    b>Delayed graft function (DGF) often occurs in kidney transplants from deceased donors. We wanted to provide studies giving more accurate non-invasive tests for acute rejection (AR)...
  53. Grossberg J, Reinert S, Monaco A, Gohh R, Morrissey P. Utility of a mathematical nomogram to predict delayed graft function: a single-center experience. Transplantation. 2006;81:155-9 pubmed
    In 2003, Irish and colleagues published a weighted nomogram designed to predict the risk of delayed graft function (DGF) in a given transplant...