sudden infant death

Summary

Summary: The abrupt and unexplained death of an apparently healthy infant under one year of age, remaining unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of the clinical history. (Pediatr Pathol 1991 Sep-Oct;11(5):677-84)

Top Publications

  1. Highet A, Berry A, Bettelheim K, Goldwater P. The frequency of molecular detection of virulence genes encoding cytolysin A, high-pathogenicity island and cytolethal distending toxin of Escherichia coli in cases of sudden infant death syndrome does not differ from that in other infant deaths and . J Med Microbiol. 2009;58:285-9 pubmed publisher
    Consistent pathological findings in sudden infant death syndrome (SIDS) are seen which display similarities to the pathogenesis of toxaemic shock and/or sepsis...
  2. Kim S, Shapiro Mendoza C, Chu S, Camperlengo L, Anderson R. Differentiating cause-of-death terminology for deaths coded as sudden infant death syndrome, accidental suffocation, and unknown cause: an investigation using US death certificates, 2003-2004. J Forensic Sci. 2012;57:364-9 pubmed publisher
    We compared written text on infant death certificates for deaths coded as sudden infant death syndrome (R95), unknown cause (R99), and accidental suffocation (W75)...
  3. Chiu M, Elder D, Zuccollo J. Gliosis in neonatal SUDI cases. Acta Paediatr. 2012;101:30-3 pubmed publisher
    ..To review sudden unexpected infant deaths (SUDI) in the first 28 days of life referred to a Coronial Perinatal Forensic Pathology Service over a 10-year period from 2000 to 2009...
  4. Leow J, Platt M. Sudden, unexpected and unexplained early neonatal deaths in the North of England. Arch Dis Child Fetal Neonatal Ed. 2011;96:F440-2 pubmed publisher
    ..The authors conclude that unexplained ENSUD is even more rare than has been appreciated and its incidence has not been altered by the considerable changes in maternity care over the last 25 years...
  5. Hanssen T, Jørgensen L. Obstruction of the lung capillaries by blood platelet aggregates and leucocytes in sudden infant death syndrome. APMIS. 2010;118:958-67 pubmed publisher
    Altogether 34 cases of sudden infant death were studied postmortem with particular emphasis on the pathological changes in the lungs...
  6. Tan B, Pundi K, Van Norstrand D, Valdivia C, Tester D, Medeiros Domingo A, et al. Sudden infant death syndrome-associated mutations in the sodium channel beta subunits. Heart Rhythm. 2010;7:771-8 pubmed publisher
    Approximately 10% of sudden infant death syndrome (SIDS) cases may stem from potentially lethal cardiac channelopathies, with approximately half of channelopathic SIDS involving the Na(V)1.5 cardiac sodium channel...
  7. Ostfeld B, Esposito L, Perl H, Hegyi T. Concurrent risks in sudden infant death syndrome. Pediatrics. 2010;125:447-53 pubmed publisher
    Despite improved education on safe sleep, infants are still exposed to multiple risks for sudden infant death syndrome (SIDS)...
  8. Pearce J, Bettelheim K, Luke R, Goldwater P. Serotypes of Escherichia coli in sudden infant death syndrome. J Appl Microbiol. 2010;108:731-5 pubmed publisher
    To examine the diversity of Escherichia coli serotypes found in the intestinal contents of infants who died of Sudden Infant Death Syndrome (SIDS) compared with that in comparison infants.
  9. McIntosh C, Tonkin S, Gunn A. What is the mechanism of sudden infant deaths associated with co-sleeping?. N Z Med J. 2009;122:69-75 pubmed
    The risk of Sudden Infant Death Syndrome (SIDS) has fallen dramatically in the "Back to Sleep" era; however, half the cases now occur when the infant has been sleeping in bed with another person...

More Information

Publications62

  1. Wood A, Pasupathy D, Pell J, Fleming M, Smith G. Trends in socioeconomic inequalities in risk of sudden infant death syndrome, other causes of infant mortality, and stillbirth in Scotland: population based study. BMJ. 2012;344:e1552 pubmed publisher
    To compare changes in inequalities in sudden infant death syndrome with other causes of infant mortality and stillbirth in Scotland, 1985-2008.
  2. Ferrante L, Opdal S, Vege A, Rognum T. IL-1 gene cluster polymorphisms and sudden infant death syndrome. Hum Immunol. 2010;71:402-6 pubmed publisher
    Several studies indicate that interleukin gene polymorphisms are of importance to sudden infant death syndrome (SIDS), and so far it has been reported that associations between SIDS and polymorphism in the genes encoding tumor necrosis ..
  3. Becher J, Bhushan S, Lyon A. Unexpected collapse in apparently healthy newborns--a prospective national study of a missing cohort of neonatal deaths and near-death events. Arch Dis Child Fetal Neonatal Ed. 2012;97:F30-4 pubmed publisher
    ..The authors undertook a prospective study to ascertain the population incidence of SUPC in the UK...
  4. Tfelt Hansen J, Winkel B, Grunnet M, Jespersen T. Cardiac channelopathies and sudden infant death syndrome. Cardiology. 2011;119:21-33 pubmed publisher
    b>Sudden infant death syndrome (SIDS) is always a devastating and unexpected occurrence. SIDS is the leading cause of death in the first 6 months after birth in the industrialized world...
  5. Winkel B, Holst A, Theilade J, Kristensen I, Thomsen J, Hansen S, et al. Sudden unexpected death in infancy in Denmark. Scand Cardiovasc J. 2011;45:14-20 pubmed publisher
    Incidence of sudden unexpected death in infancy (SUDI) and sudden infant death syndrome (SIDS) differs among studies and non-autopsied cases are difficult to assess.
  6. Duncan J, Garland M, Myers M, Fifer W, Yang M, Kinney H, et al. Prenatal nicotine-exposure alters fetal autonomic activity and medullary neurotransmitter receptors: implications for sudden infant death syndrome. J Appl Physiol (1985). 2009;107:1579-90 pubmed publisher
    During pregnancy, exposure to nicotine and other compounds in cigarette smoke increases the risk of the sudden infant death syndrome (SIDS) two- to fivefold...
  7. Dettmeyer R, Baasner A, Haag C, Bruch S, Schlamann M. Immunohistochemical and molecular-pathological diagnosis of myocarditis in cases of suspected sudden infant death syndrome (SIDS)--a multicenter study. Leg Med (Tokyo). 2009;11 Suppl 1:S124-7 pubmed publisher
    ..Preliminary criteria for cellular immunohistochemical diagnosis of viral myocardial affections derived from these findings were suggested...
  8. Kinney H, Thach B. The sudden infant death syndrome. N Engl J Med. 2009;361:795-805 pubmed publisher
  9. Dwyer T, Ponsonby A. Sudden infant death syndrome and prone sleeping position. Ann Epidemiol. 2009;19:245-9 pubmed publisher
    ..review, we describe the epidemiological work conducted by ourselves and others on prone sleep position and sudden infant death. What we have learned since 1990 is that the prone sleep position was a major component of a casual pathway ..
  10. Escott A, Elder D, Zuccollo J. Sudden unexpected infant death and bedsharing: referrals to the Wellington Coroner 1997-2006. N Z Med J. 2009;122:59-68 pubmed
    ..To describe the factors associated with sudden unexpected infant deaths, for which there was no clear medical diagnosis, referred to the Wellington-based coronial paediatric pathology service over the decade from 1997 to 2006...
  11. Paterson D, Hilaire G, Weese Mayer D. Medullary serotonin defects and respiratory dysfunction in sudden infant death syndrome. Respir Physiol Neurobiol. 2009;168:133-43 pubmed publisher
    b>Sudden infant death syndrome (SIDS) is defined as the sudden and unexpected death of an infant less than 12 months of age that occurs during sleep and remains unexplained after a complete autopsy, death scene investigation, and review of ..
  12. Lavezzi A, Weese Mayer D, Yu M, Jennings L, Corna M, Casale V, et al. Developmental alterations of the respiratory human retrotrapezoid nucleus in sudden unexplained fetal and infant death. Auton Neurosci. 2012;170:12-9 pubmed publisher
    ..in victims of sudden perinatal and infant death (sudden intrauterine unexplained death/SIUD - and sudden infant death syndrome/SIDS)...
  13. Vennemann M, Bajanowski T, Brinkmann B, Jorch G, Yücesan K, Sauerland C, et al. Does breastfeeding reduce the risk of sudden infant death syndrome?. Pediatrics. 2009;123:e406-10 pubmed publisher
    In the last 20 years, the prevention campaigns to reduce the risk of sudden infant death syndrome were very successful. In some countries the advice to breastfeed is included in the campaigns' messages, but in other countries it is not.
  14. Hauck F, Thompson J, Tanabe K, Moon R, Vennemann M. Breastfeeding and reduced risk of sudden infant death syndrome: a meta-analysis. Pediatrics. 2011;128:103-10 pubmed publisher
    Benefits of breastfeeding include lower risk of postneonatal mortality. However, it is unclear whether breastfeeding specifically lowers sudden infant death syndrome (SIDS) risk, because study results have been conflicting.
  15. Millat G, Kugener B, Chevalier P, Chahine M, Huang H, Malicier D, et al. Contribution of long-QT syndrome genetic variants in sudden infant death syndrome. Pediatr Cardiol. 2009;30:502-9 pubmed publisher
    ..to better quantify the contribution of long-QT syndrome (LQTS) genetic variants in French cases of sudden infant death syndrome (SIDS)...
  16. Slotkin T, Seidler F, Spindel E. Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant death syndrome: amelioration by vitamin C. Neurotoxicol Teratol. 2011;33:431-4 pubmed publisher
    ..smoking during pregnancy greatly enhances perinatal morbidity/mortality and is the major risk factor for Sudden Infant Death Syndrome (SIDS)...
  17. Tang S, Machaalani R, Waters K. Expression of brain-derived neurotrophic factor and TrkB receptor in the sudden infant death syndrome brainstem. Respir Physiol Neurobiol. 2012;180:25-33 pubmed publisher
    ..study compared the expression of BDNF (proBDNF and rhBDNF forms) and its receptor TrkB, in the medulla of sudden infant death syndrome (SIDS) infants and infants who died from known causes (non-SIDS)...
  18. Vennemann M, Loddenkötter B, Fracasso T, Mitchell E, Debertin A, Larsch K, et al. Cytokines and sudden infant death. Int J Legal Med. 2012;126:279-84 pubmed publisher
    ..It has been hypothesised that inflammatory reactions could play an important role in the pathway(s) leading to sudden and unexpected death in infancy. On a molecular level, these reactions are regulated by various cytokines...
  19. Chu C, Zhou W, Gui Y, Kan H. Diurnal temperature range as a novel risk factor for sudden infant death. Biomed Environ Sci. 2011;24:518-22 pubmed publisher
    To assess the relationship between diurnal temperature range (DTR) and sudden infant death (SID) between 2001 and 2004 in Shanghai, China.
  20. Senter L, Sackoff J, Landi K, Boyd L. Studying sudden and unexpected infant deaths in a time of changing death certification and investigation practices: evaluating sleep-related risk factors for infant death in New York City. Matern Child Health J. 2011;15:242-8 pubmed publisher
    ..This will help jurisdictions interpret their infant mortality statistics, which in turn will improve education and prevention efforts...
  21. Duncan J, Paterson D, Hoffman J, Mokler D, Borenstein N, Belliveau R, et al. Brainstem serotonergic deficiency in sudden infant death syndrome. JAMA. 2010;303:430-7 pubmed publisher
    b>Sudden infant death syndrome (SIDS) is postulated to result from abnormalities in brainstem control of autonomic function and breathing during a critical developmental period...
  22. Neary M, Mohun T, Breckenridge R. A mouse model to study the link between hypoxia, long QT interval and sudden infant death syndrome. Dis Model Mech. 2013;6:503-7 pubmed publisher
    The pathology of sudden infant death syndrome (SIDS) is poorly understood. Many risk factors, including hypoxia, have been identified...
  23. Weber M, Ashworth M, Risdon R, Brooke I, Malone M, Sebire N. Sudden unexpected neonatal death in the first week of life: autopsy findings from a specialist centre. J Matern Fetal Neonatal Med. 2009;22:398-404 pubmed publisher
    ..The aim of this study was to review SUEND autopsies performed in a single specialist centre over a 10-year period, (1996-2005)...
  24. Haas C, Braun J, Bär W, Bartsch C. No association of serotonin transporter gene variation with sudden infant death syndrome (SIDS) in Caucasians. Leg Med (Tokyo). 2009;11 Suppl 1:S210-2 pubmed publisher
  25. Fracasso T, Vennemann M, Pfeiffer H, Bajanowski T. Organ weights in cases of sudden infant death syndrome: a German study. Am J Forensic Med Pathol. 2009;30:231-4 pubmed publisher
    Despite its decreasing incidence, sudden infant death syndrome (SIDS) still remains an important cause of death in infancy. Since Felix Platter described the case of a child suffocated because of a massive goiter (Platter E...
  26. Andres V, Garcia P, Rimet Y, Nicaise C, Simeoni U. Apparent life-threatening events in presumably healthy newborns during early skin-to-skin contact. Pediatrics. 2011;127:e1073-6 pubmed publisher
    ..Although many ALTEs are apparently caused by obstruction, we suggest that a standardized investigational workup be performed after an ALTE...
  27. McDonnell Naughton M, McGarvey C, O REGAN M, Matthews T. Maternal smoking and alcohol consumption during pregnancy as risk factors for sudden infant death. Ir Med J. 2012;105:105-8 pubmed
    ..The adjusted odds ratio for those consuming alcohol in all three trimesters was 3.59 (CI:1.40-9.20). Both of these risk factors are modifiable and need to be incorporated into antenatal education from a SIDS point of view...
  28. Trachtenberg F, Haas E, Kinney H, Stanley C, Krous H. Risk factor changes for sudden infant death syndrome after initiation of Back-to-Sleep campaign. Pediatrics. 2012;129:630-8 pubmed publisher
    To test the hypothesis that the profile of sudden infant death syndrome (SIDS) changed after the Back-to-Sleep (BTS) campaign initiation, document prevalence and patterns of multiple risks, and determine the age profile of risk factors.
  29. Sinclair G, Collins S, Popescu O, McFadden D, Arbour L, Vallance H. Carnitine palmitoyltransferase I and sudden unexpected infant death in British Columbia First Nations. Pediatrics. 2012;130:e1162-9 pubmed publisher
    ..This work was initiated to determine the performance of acylcarnitine profiling for detecting this variant, to determine its frequency in BC, and to determine if it is associated with sudden infant deaths in this population...
  30. Toruner G, Kurvathi R, Sugalski R, Shulman L, Twersky S, Pearson P, et al. Copy number variations in three children with sudden infant death. Clin Genet. 2009;76:63-8 pubmed publisher
    ..When an explanation cannot be found, the case is labeled as sudden infant death syndrome or unclassified sudden infant death...
  31. Ottaviani G. Sudden infant and perinatal unexplained death: are we moving forward yet?. Cardiovasc Pathol. 2011;20:302-6 pubmed publisher
    ..system and cardiac conducting system dysfunctions have been proposed to be implied in the pathogenesis of sudden infant death syndrome (SIDS)...
  32. Livolsi A, Niederhoffer N, Dali Youcef N, Rambaud C, Olexa C, Mokni W, et al. Cardiac muscarinic receptor overexpression in sudden infant death syndrome. PLoS ONE. 2010;5:e9464 pubmed publisher
    b>Sudden infant death syndrome (SIDS) remains the leading cause of death among infants less than 1 year of age...
  33. Poets A, Urschitz M, Steinfeldt R, Poets C. Risk factors for early sudden deaths and severe apparent life-threatening events. Arch Dis Child Fetal Neonatal Ed. 2012;97:F395-7 pubmed publisher
    ..To identify potential risk factors for unexpected sudden infant deaths (SID) and severe apparent life-threatening events (S-ALTE) within 24 h of birth...
  34. Van Nguyen J, Abenhaim H. Sudden infant death syndrome: review for the obstetric care provider. Am J Perinatol. 2013;30:703-14 pubmed publisher
    b>Sudden infant death syndrome (SIDS) is the leading cause of death among infants aged 1 to 12 months. In this article, we review risk factors that may predispose infants to increased vulnerability...
  35. Schnitzer P, Covington T, Dykstra H. Sudden unexpected infant deaths: sleep environment and circumstances. Am J Public Health. 2012;102:1204-12 pubmed publisher
    ..infants who die suddenly and unexpectedly and to examine similarities and differences in risk factors among infants whose deaths are classified as resulting from sudden infant death syndrome (SIDS), suffocation, or undetermined causes.
  36. Tsao P, Chang F, Chen S, Soong W, Jeng M, Lee Y, et al. Sudden and unexpected and near death during the early neonatal period: a multicenter study. J Chin Med Assoc. 2012;75:65-9 pubmed publisher
    ..To investigate the incidence, clinical presentation and possible etiologies or risk factors of early onset of sudden and unexpected death or near-miss...
  37. Klaver E, Versluijs G, Wilders R. Cardiac ion channel mutations in the sudden infant death syndrome. Int J Cardiol. 2011;152:162-70 pubmed publisher
    b>Sudden infant death syndrome (SIDS) is characterized by the sudden death of an infant that occurs during sleep and remains unexplained despite thorough examination...
  38. Waters K. Serotonin in the sudden infant death syndrome. Drug News Perspect. 2010;23:537-48 pubmed publisher
    It seems likely that some infants who die from sudden infant death syndrome (SIDS) have a brainstem abnormality of the serotonergic system...
  39. Highet A, Berry A, Goldwater P. Novel hypothesis for unexplained sudden unexpected death in infancy (SUDI). Arch Dis Child. 2009;94:841-3 pubmed publisher
    ..The objective was to assess these observations in the context of the pathology and epidemiology of sudden infant death syndrome (SIDS) in relation to the role of infection and inflammation as triggers of these deaths.
  40. Peters C, Becher J, Lyon A, Midgley P. Who is blaming the baby?. Arch Dis Child Fetal Neonatal Ed. 2009;94:F377-8 pubmed publisher
    ..It is postulated that some infants with an underlying vulnerability may maladapt to extrauterine life following an hypoxic stressor possibly caused by positional airway obstruction...
  41. Kadhim H, Deltenre P, De Prez C, Sebire G. Interleukin-2 as a neuromodulator possibly implicated in the physiopathology of sudden infant death syndrome. Neurosci Lett. 2010;480:122-6 pubmed publisher
    ..centers, including those controlling cardiorespiratory- and sleep/arousal pathophysiology, is reported in sudden infant death syndrome (SIDS). Biological mechanisms underlying SIDS, however, remain unclear...
  42. Shapiro Mendoza C, Kim S, Chu S, Kahn E, Anderson R. Using death certificates to characterize sudden infant death syndrome (SIDS): opportunities and limitations. J Pediatr. 2010;156:38-43 pubmed publisher
    To examine cause-of-death terminology written on death certificates for sudden infant death syndrome (SIDS) and to determine the adequacy of this text data in more fully describing circumstances potentially contributing to SIDS deaths.
  43. Krous H, Haas E, Chadwick A, Masoumi H, Stanley C. Intrathoracic petechiae in SIDS: a retrospective population-based 15-year study. Forensic Sci Med Pathol. 2008;4:234-9 pubmed publisher
    Intrathoracic petechiae (IP), the most common gross finding in sudden infant death syndrome (SIDS) cases at autopsy, suggest upper airway obstruction (UAO) occurs during the terminal event...
  44. Hutchison B, Rea C, Stewart A, Koelmeyer T, Tipene Leach D, Mitchell E. Sudden unexpected infant death in Auckland: a retrospective case review. Acta Paediatr. 2011;100:1108-12 pubmed publisher
    ..To review autopsy reports of all SUDI deaths in the Auckland region, New Zealand, from October 2000 to December 2009...
  45. Highet A, Goldwater P. Staphylococcal enterotoxin genes are common in Staphylococcus aureus intestinal flora in Sudden Infant Death Syndrome (SIDS) and live comparison infants. FEMS Immunol Med Microbiol. 2009;57:151-5 pubmed publisher
    Pathological and epidemiological findings in sudden infant death syndrome (SIDS) suggest an infectious aetiology with indications of involvement of staphylococcal enterotoxins (SEs)...
  46. Blair P, Sidebotham P, Evason Coombe C, Edmonds M, Heckstall Smith E, Fleming P. Hazardous cosleeping environments and risk factors amenable to change: case-control study of SIDS in south west England. BMJ. 2009;339:b3666 pubmed publisher
    To investigate the factors associated with sudden infant death syndrome (SIDS) from birth to age 2 years, whether recent advice has been followed, whether any new risk factors have emerged, and the specific circumstances in which SIDS ..
  47. Webb R, Wicks S, Dalman C, Pickles A, Appleby L, Mortensen P, et al. Influence of environmental factors in higher risk of sudden infant death syndrome linked with parental mental illness. Arch Gen Psychiatry. 2010;67:69-77 pubmed publisher
    Since national risk reduction campaigns have been conducted, sudden infant death syndrome (SIDS) has become increasingly concentrated among disadvantaged families, including those affected by mental illness...
  48. Brion M, Allegue C, Santori M, Gil R, Blanco Verea A, Haas C, et al. Sarcomeric gene mutations in sudden infant death syndrome (SIDS). Forensic Sci Int. 2012;219:278-81 pubmed publisher
    In developed countries, sudden infant death syndrome (SIDS) represents the most prevalent cause of death in children between 1 month and 1 year of age...
  49. Opdal S, Rognum T. Gene variants predisposing to SIDS: current knowledge. Forensic Sci Med Pathol. 2011;7:26-36 pubmed publisher
    ..A dehydrogenase deficiency and cardiac arrest due to long QT syndrome, or as predisposing factors for sudden infant death syndrome (SIDS)...
  50. Ferrante L, Opdal S, Vege A, Rognum T. Cytokine gene polymorphisms and sudden infant death syndrome. Acta Paediatr. 2010;99:384-8 pubmed publisher
    Several studies indicate that the mucosal immune system is stimulated in cases of sudden infant death syndrome (SIDS), and our hypothesis is that this immune reaction is because of an unfavourable combination of functional polymorphisms ..
  51. Van Norstrand D, Asimaki A, Rubinos C, Dolmatova E, Srinivas M, Tester D, et al. Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death. Circulation. 2012;125:474-81 pubmed publisher
    An estimated 10% to 15% of sudden infant death syndrome (SIDS) cases may stem from channelopathy-mediated lethal arrhythmias...
  52. Lavezzi A, Corna M, Matturri L. Ependymal alterations in sudden intrauterine unexplained death and sudden infant death syndrome: possible primary consequence of prenatal exposure to cigarette smoking. Neural Dev. 2010;5:17 pubmed publisher
    ..Additionally, we investigated a possible link between alterations of this structure, sudden unexplained fetal and infant death and maternal smoking...
  53. Gessner B, Gillingham M, BIRCH S, Wood T, Koeller D. Evidence for an association between infant mortality and a carnitine palmitoyltransferase 1A genetic variant. Pediatrics. 2010;126:945-51 pubmed publisher
    ..1436C?T) in the gene coding for carnitine palmitoyltransferase type 1A (CPT1A). We sought to determine whether these 2 findings were related...