Summary: Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.

Top Publications

  1. Sauzeau V, Jerkic M, Lopez Novoa J, Bustelo X. Loss of Vav2 proto-oncogene causes tachycardia and cardiovascular disease in mice. Mol Biol Cell. 2007;18:943-52 pubmed
    ..Here, we report that this is the case for Vav2, because the disruption of its locus in mice causes tachycardia, hypertension, and defects in the heart, arterial walls, and kidneys...
  2. Surges R, Scott C, Walker M. Enhanced QT shortening and persistent tachycardia after generalized seizures. Neurology. 2010;74:421-6 pubmed publisher
    ..Secondarily GTCS led to higher ictal HR, persistent postictal tachycardia, and decreased postictal HR variability...
  3. Ellis E, Josephson M. Heart failure and tachycardia-induced cardiomyopathy. Curr Heart Fail Rep. 2013;10:296-306 pubmed publisher
    ..Long-standing tachycardia is a well-recognized cause of heart failure and left ventricular dysfunction and has led to the nomenclature, ..
  4. Nagamoto Y, Inage T, Yoshida T, Takeuchi T, Gondo T, Fukuda Y, et al. Atrioventricular nodal ablation versus antiarrhythmic drugs after permanent pacemaker implantation for bradycardia-tachycardia syndrome. Heart Vessels. 2012;27:174-8 pubmed publisher
    Patients often require antiarrhythmic drugs to control tachycardia after permanent pacemaker implantation (PMI) for bradycardia-tachycardia syndrome...
  5. Duhme N, Schweizer P, Thomas D, Becker R, Schröter J, Barends T, et al. Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillation. Eur Heart J. 2013;34:2768-75 pubmed publisher
    ..The index patient developed tachycardia-bradycardia syndrome and persistent atrial fibrillation (AF) in an age-dependent fashion...
  6. Nakatani Y, Nishida K, Sakabe M, Kataoka N, Sakamoto T, Yamaguchi Y, et al. Tranilast prevents atrial remodeling and development of atrial fibrillation in a canine model of atrial tachycardia and left ventricular dysfunction. J Am Coll Cardiol. 2013;61:582-8 pubmed publisher
    ..28 ± 0.20, p < 0.05 vs. control). Tranilast prevented atrial remodeling and suppressed AF development in a canine model. Its inhibition of TGF-?1 and Rac1 overexpression may contribute to its antiremodeling effects. ..
  7. Kozłowska H, Baranowska Kuczko M, Schlicker E, Kozłowski M, Zakrzeska A, Grzęda E, et al. EP₃ receptor-mediated contraction of human pulmonary arteries and inhibition of neurogenic tachycardia in pithed rats. Pharmacol Rep. 2012;64:1526-36 pubmed
    ..and (2) the examination of the potential involvement of these receptors in the regulation of neurogenic tachycardia in pithed rats. L-826266 served as the EP(3) receptor antagonist...
  8. Kiczak L, Tomaszek A, Bania J, Paslawska U, Zacharski M, Noszczyk Nowak A, et al. Expression and complex formation of MMP9, MMP2, NGAL, and TIMP1 in porcine myocardium but not in skeletal muscles in male pigs with tachycardia-induced systolic heart failure. Biomed Res Int. 2013;2013:283856 pubmed publisher
    ..In skeletal muscles from both diseased and healthy animals, in nonreducing and nondenaturing conditions, we found no HMW complexes, and proteolytic activity was associated with the presence of 72 and 68?kDa bands (proMMP2 and MMP2)...
  9. Díez J, Hernándiz A, Cosin Aguilar J, Aguilar A, Portolés M. Sum of effects of myocardial ischemia followed by electrically induced tachycardia on myocardial function. Med Sci Monit Basic Res. 2013;19:153-62 pubmed publisher
    ..resulted in worse impairment of overall cardiac and regional function that continued to be altered 1 h after tachycardia ceased. There was significant reduction of stroke volume (26.9 ± 5.3 basal vs. 16 ± 6.2 ml; p<0...

More Information


  1. Arevalo H, Plank G, Helm P, Halperin H, Trayanova N. Tachycardia in post-infarction hearts: insights from 3D image-based ventricular models. PLoS ONE. 2013;8:e68872 pubmed publisher
    Ventricular tachycardia, a life-threatening regular and repetitive fast heart rhythm, frequently occurs in the setting of myocardial infarction...
  2. Liu N, Ruan Y, Denegri M, Bachetti T, Li Y, Colombi B, et al. Calmodulin kinase II inhibition prevents arrhythmias in RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia. J Mol Cell Cardiol. 2011;50:214-22 pubmed publisher
    Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmogenic disease characterized by life-threatening arrhythmias elicited by adrenergic activation...
  3. Kanjwal K, Karabin B, Kanjwal Y, Grubb B. Autonomic dysfunction presenting as postural orthostatic tachycardia syndrome in patients with multiple sclerosis. Int J Med Sci. 2010;7:62-7 pubmed
    ..However, there have been no reports on postural orthostatic tachycardia syndrome (POTS) in patients suffering from MS...
  4. Raj S, Black B, Biaggioni I, Paranjape S, Ramirez M, Dupont W, et al. Propranolol decreases tachycardia and improves symptoms in the postural tachycardia syndrome: less is more. Circulation. 2009;120:725-34 pubmed publisher
    Postural tachycardia syndrome (POTS) induces disabling chronic orthostatic intolerance with an excessive increase in heart rate on standing...
  5. Apipan B, Rummasak D. Efficacy and safety of oral propranolol premedication to reduce reflex tachycardia during hypotensive anesthesia with sodium nitroprusside in orthognathic surgery: a double-blind randomized clinical trial. J Oral Maxillofac Surg. 2010;68:120-4 pubmed publisher
    ..with oral propranolol 10 mg before hypotensive anesthesia with sodium nitroprusside could reduce reflex tachycardia, the amount of sodium nitroprusside used, and blood loss during hypotensive anesthesia for orthognathic surgery.
  6. Jolly K, Gammage M, Cheng K, Bradburn P, Banting M, Langman M. Sudden death in patients receiving drugs tending to prolong the QT interval. Br J Clin Pharmacol. 2009;68:743-51 pubmed publisher
    ..Tricyclic antidepressants were not associated with raised risks. The Arizona classification of risk of TdP was a poor predictor of likelihood of noncardiac drug-associated sudden death. ..
  7. Liu E, Xu Z, Li J, Yang S, Yang W, Li G. Enalapril, irbesartan, and angiotensin-(1-7) prevent atrial tachycardia-induced ionic remodeling. Int J Cardiol. 2011;146:364-70 pubmed publisher
    ..01 vs. control). Irbesartan had no effect on I(TO) and I(CaL) densities or mRNA expression. These results suggest that enalapril, irbesartan, and Ang-(1-7) have differing influences on atrial tachycardia-induced atrial ionic remodeling.
  8. Piccirillo G, Magrì D, Ogawa M, Song J, Chong V, Han S, et al. Autonomic nervous system activity measured directly and QT interval variability in normal and pacing-induced tachycardia heart failure dogs. J Am Coll Cardiol. 2009;54:840-50 pubmed publisher
    ..between sympathetic and vagal nerve activity and the cardiac repolarization in a canine model of pacing-induced tachycardia congestive heart failure (CHF)...
  9. Passariello M, Perkins R. Unexpected postoperative tachycardia in a patient with 22q11 deletion syndrome after multiple dental extractions. Paediatr Anaesth. 2005;15:1145-6 pubmed
  10. Pizzale S, Lemery R, Green M, Gollob M, Tang A, Birnie D. Frequency and predictors of tachycardia-induced cardiomyopathy in patients with persistent atrial flutter. Can J Cardiol. 2009;25:469-72 pubmed
    There are few data on the frequency and predictors of tachycardia-induced cardiomyopathy (TICM) in patients with persistent atrial flutter...
  11. Palatini P. Elevated heart rate in cardiovascular diseases: a target for treatment?. Prog Cardiovasc Dis. 2009;52:46-60 pubmed publisher
    ..Treatment of high heart rate in healthy subjects appears to be premature, but in clinical conditions such as hypertension or diabetes, the reduction of elevated heart rate appears a desirable additional goal of therapy. ..
  12. Piccirillo G, Ogawa M, Song J, Chong V, Joung B, Han S, et al. Power spectral analysis of heart rate variability and autonomic nervous system activity measured directly in healthy dogs and dogs with tachycardia-induced heart failure. Heart Rhythm. 2009;6:546-52 pubmed publisher
  13. Zhang L, Cheng J, Liu X, Wang S, Liu Y, Lu H, et al. Cardiovascular changes of conscious rats after simulated microgravity with and without daily -Gx gravitation. J Appl Physiol (1985). 2008;105:1134-45 pubmed publisher
    ..Nonlinear measures, but not spectral analysis, might provide promising data to estimate the overall changes in cardiovascular autonomic regulation due to microgravity exposure. ..
  14. Groh W, Groh M, Saha C, Kincaid J, Simmons Z, Ciafaloni E, et al. Electrocardiographic abnormalities and sudden death in myotonic dystrophy type 1. N Engl J Med. 2008;358:2688-97 pubmed publisher
    ..A severe abnormality on the ECG and a diagnosis of an atrial tachyarrhythmia predict sudden death. (ClinicalTrials.gov number, NCT00622453.) ..
  15. Grubb B. Postural tachycardia syndrome. Circulation. 2008;117:2814-7 pubmed publisher
  16. Zweng A, Schuster R, Hawlicek R, Weber H. Life-threatening pacemaker dysfunction associated with therapeutic radiation: a case report. Angiology. 2009;60:509-12 pubmed publisher
    ..It could be concluded that the PM dysfunction was most likely induced by EMI during radiotherapy. The real reason of the device's software failure remains unclear. ..
  17. Voigt N, Maguy A, Yeh Y, Qi X, Ravens U, Dobrev D, et al. Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes. Cardiovasc Res. 2008;77:35-43 pubmed
    Although atrial tachycardia (AT) remodelling promotes agonist-independent, constitutively active, acetylcholine-regulated K+-current (I K,ACh) that increases susceptibility to atrial fibrillation (AF), the underlying changes in I K,Ach ..
  18. Agarwal A, Garg R, Ritch A, Sarkar P. Postural orthostatic tachycardia syndrome. Postgrad Med J. 2007;83:478-80 pubmed
    Postural orthostatic tachycardia syndrome (POTS) is an autonomic disturbance which has become better understood in recent years...
  19. Mazzanti G, Di Sotto A, Daniele C, Battinelli L, Brambilla G, Fiori M, et al. A pharmacodynamic study on clenbuterol-induced toxicity: beta1- and beta2-adrenoceptors involvement in guinea-pig tachycardia in an in vitro model. Food Chem Toxicol. 2007;45:1694-9 pubmed
    ..Following consumption of meat or liver, intoxication cases were described, and cardiovascular toxic effects (tachycardia, hypertension) were of clinical relevance...
  20. Vinik A, Ziegler D. Diabetic cardiovascular autonomic neuropathy. Circulation. 2007;115:387-97 pubmed
  21. Corbett W, Reiter C, Schultz J, Kanter R, Habib A. Anaesthetic management of a parturient with the postural orthostatic tachycardia syndrome: a case report. Br J Anaesth. 2006;97:196-9 pubmed
    Postural orthostatic tachycardia syndrome encompasses a group of disorders characterized by orthostatic intolerance...
  22. Matsumoto K, Ishikawa T, Sumita S, Matsushita K, Inoue N, Kobayashi T, et al. Assessment of atrial regional wall motion using strain Doppler imaging during biatrial pacing in the bradycardia-tachycardia syndrome. Pacing Clin Electrophysiol. 2006;29:220-5 pubmed
    ..9 +/- 24.1 vs 129.9 +/- 30.6 ms, P = 0.0086) and LLA (102.2 +/- 37.9 vs 166.1 +/- 13.4 ms, P = 0.0028). BiA pacing improved the synchronicity of regional wall motion of both atrium. ..
  23. Stewart J, Medow M, Cherniack N, Natelson B. Postural hypocapnic hyperventilation is associated with enhanced peripheral vasoconstriction in postural tachycardia syndrome with normal supine blood flow. Am J Physiol Heart Circ Physiol. 2006;291:H904-13 pubmed
    Previous investigations have demonstrated a subset of postural tachycardia syndrome (POTS) patients characterized by normal peripheral resistance and blood volume while supine but thoracic hypovolemia and splanchnic blood pooling while ..