intestinal polyps

Summary

Summary: Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.

Top Publications

  1. Katsinelos P, Kountouras J, Chatzimavroudis G, Zavos C, Pilpilidis I, Fasoulas K, et al. Wireless capsule endoscopy in detecting small-intestinal polyps in familial adenomatous polyposis. World J Gastroenterol. 2009;15:6075-9 pubmed
    ..To detect the prevalence of small bowel polyps by wireless capsule endoscopy (WCE) in patients with familial adenomatous polyposis (FAP)...
  2. Nnadi S, Watson R, Innocent J, Gonye G, Buchberg A, Siracusa L. Identification of five novel modifier loci of Apc(Min) harbored in the BXH14 recombinant inbred strain. Carcinogenesis. 2012;33:1589-97 pubmed publisher
    ..Thus, the significance of this work resides not only with the modifier loci we identified but also with the combinations of loci needed to get maximal protection against polyposis and the impact of this finding on human disease studies...
  3. Carr N, Mahajan H, Tan K, Hawkins N, Ward R. Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma. J Clin Pathol. 2009;62:516-8 pubmed publisher
    ..To determine the prevalence of colorectal polyps of different types in an unselected population, and to correlate the morphological diagnoses with BRAF mutation analysis...
  4. Gaspar C, Cardoso J, Franken P, Molenaar L, Morreau H, Möslein G, et al. Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis. Am J Pathol. 2008;172:1363-80 pubmed publisher
    ..Here, we applied a cross-species comparison of expression profiles of intestinal polyps derived from hereditary colorectal cancer patients carrying APC germline mutations and from mice carrying a ..
  5. Schulmann K, Pox C, Tannapfel A, Schmiegel W. The patient with multiple intestinal polyps. Best Pract Res Clin Gastroenterol. 2007;21:409-26 pubmed
    The management of patients with multiple intestinal polyps may be difficult and greatly depends on the correct classification. Polyposis syndromes account for less than 1% of newly diagnosed colorectal cancers...
  6. Lee S, Hu L, Gonzalez Navajas J, Seo G, Shen C, Brick J, et al. ERK activation drives intestinal tumorigenesis in Apc(min/+) mice. Nat Med. 2010;16:665-70 pubmed publisher
    ..Our data reveal a new facet of oncogene-environment interaction, in which microflora-induced TLR activation regulates oncogene expression and related IEC tumor growth in a susceptible host...
  7. Lash R, Genta R, Schuler C. Sessile serrated adenomas: prevalence of dysplasia and carcinoma in 2139 patients. J Clin Pathol. 2010;63:681-6 pubmed publisher
    ..This study attempts to estimate the progression rate of SSAs based upon the epidemiology of a large cohort as well as identify relationships to other colorectal polyps...
  8. Mbengue M, Dia D, Diouf M, Bassène M, Fall S, Diallo S, et al. [Contribution of coloscopy to diagnosis of rectal bleeding in Dakar (Senegal)]. Med Trop (Mars). 2009;69:286-8 pubmed
    ..The purpose of this report is to describe lesions discovered by coloscopy in patients assessed for rectal bleeding in Dakar, Senegal...
  9. Torlakovic E, Gomez J, Driman D, Parfitt J, Wang C, Benerjee T, et al. Sessile serrated adenoma (SSA) vs. traditional serrated adenoma (TSA). Am J Surg Pathol. 2008;32:21-9 pubmed

More Information

Publications62

  1. Farris A, Misdraji J, Srivastava A, Muzikansky A, Deshpande V, Lauwers G, et al. Sessile serrated adenoma: challenging discrimination from other serrated colonic polyps. Am J Surg Pathol. 2008;32:30-5 pubmed
    ..However, this level of variability is acceptable because the presence of SSA indicates increased risk of developing additional serrated polyps and carcinoma, and surveillance is appropriate...
  2. Kim K, Lee E, Ha S, Kang S, Jang K, Park C, et al. Molecular features of colorectal hyperplastic polyps and sessile serrated adenoma/polyps from Korea. Am J Surg Pathol. 2011;35:1274-86 pubmed publisher
    ..left) may be a more significant risk factor of progression than the histologic type of polyp. Our data also support the theory that right-sided MVHPs may be a precursor to SSA/P...
  3. Yamaguchi K, Cekanova M, McEntee M, Yoon J, Fischer S, Renes I, et al. Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways. Mol Cancer Ther. 2008;7:2779-87 pubmed publisher
    ..Subsequently, treatment with MCC-555 (30 mg/kg/d) for 4 weeks reduced the number of small intestinal polyps to 54.8% of that in control mice...
  4. Mutoh M, Komiya M, Teraoka N, Ueno T, Takahashi M, Kitahashi T, et al. Overexpression of low-density lipoprotein receptor and lipid accumulation in intestinal polyps in Min mice. Int J Cancer. 2009;125:2505-10 pubmed publisher
    ..lipase (LPL), high concentration of serum triglyceride (TG), fatty change of the liver and large numbers of intestinal polyps. We have reported that induction of LPL expression reduces serum lipid, especially TG, improves fatty change ..
  5. Fuseler J, Bedenbaugh A, Yekkala K, Baudino T. Fractal and image analysis of the microvasculature in normal intestinal submucosa and intestinal polyps in Apc(Min/+) mice. Microsc Microanal. 2010;16:73-9 pubmed publisher
    ..analysis to quantify differences in the complexity of the vasculature in normal intestinal submucosa and intestinal polyps. Apc(Min/+) mice and wild-type mice were perfused with a curable latex compound, intestines sectioned, and ..
  6. Rajamanickam S, Velmurugan B, Kaur M, Singh R, Agarwal R. Chemoprevention of intestinal tumorigenesis in APCmin/+ mice by silibinin. Cancer Res. 2010;70:2368-78 pubmed publisher
    ..o. silibinin feeding against spontaneous intestinal tumorigenesis in the APC(min/+) mice model, suggesting its chemopreventive potential against intestinal cancers including CRC...
  7. Consolo P, Luigiano C, Strangio G, Scaffidi M, Giacobbe G, Di Giuseppe G, et al. Efficacy, risk factors and complications of endoscopic polypectomy: ten year experience at a single center. World J Gastroenterol. 2008;14:2364-9 pubmed
    ..To examine the efficacy and complications of colonoscopic resection of colorectal polypoid lesions...
  8. West N, Clark S, Phillips R, Hutchinson J, Leicester R, Belluzzi A, et al. Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis. Gut. 2010;59:918-25 pubmed publisher
  9. Arebi N, Swain D, Suzuki N, Fraser C, Price A, Saunders B. Endoscopic mucosal resection of 161 cases of large sessile or flat colorectal polyps. Scand J Gastroenterol. 2007;42:859-66 pubmed
    ..The aim of this study was to identify the factors that may be predictive of the risk of polyp recurrence...
  10. Chai N, Zhang W, Wang Y, Zhou Z, Zhang Y, Liu H, et al. [Lgr5 and CD44 expressions in different types of intestinal polyps and colorectal cancer]. Nan Fang Yi Ke Da Xue Xue Bao. 2013;33:972-6 pubmed
    To study the expression of tumorigenesis-related stem cell markers Lgr5 and CD44 in different pathological types of intestinal polyps and their clinical significance in predicting tumorigenesis.
  11. Fini L, Piazzi G, Daoud Y, Selgrad M, Maegawa S, Garcia M, et al. Chemoprevention of intestinal polyps in ApcMin/+ mice fed with western or balanced diets by drinking annurca apple polyphenol extract. Cancer Prev Res (Phila). 2011;4:907-15 pubmed publisher
  12. Bongers G, Muniz L, Pacer M, Iuga A, Thirunarayanan N, Slinger E, et al. A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans. Gastroenterology. 2012;143:730-740 pubmed publisher
    ..Tumors that arise from these polyps frequently contain activating mutations in BRAF or KRAS, but little is known about the role of EGFR activation in their development...
  13. Kohonen Corish M, Sigglekow N, Susanto J, Chapuis P, Bokey E, Dent O, et al. Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer. Oncogene. 2007;26:4435-41 pubmed
    ..Furthermore, MCC methylation is significantly associated with a distinct spectrum of precursor lesions, which are suggested to give rise to cancers via the serrated neoplasia pathway...
  14. van Gelder R, Venema H, Serlie I, Nio C, Determann R, Tipker C, et al. CT colonography at different radiation dose levels: feasibility of dose reduction. Radiology. 2002;224:25-33 pubmed
    ..To investigate the sensitivity and specificity of polyp detection and the image quality of computed tomographic (CT) colonography at different radiation dose levels and to study effective doses reported in literature on CT colonography...
  15. Sandmeier D, Seelentag W, Bouzourene H. Serrated polyps of the colorectum: is sessile serrated adenoma distinguishable from hyperplastic polyp in a daily practice?. Virchows Arch. 2007;450:613-8 pubmed
    ..One SSA of our series showed low-grade dysplasia supporting the concept that this lesion might be a precursor of serrated adenocarcinoma...
  16. Hu R, Khor T, Shen G, Jeong W, Hebbar V, Chen C, et al. Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable. Carcinogenesis. 2006;27:2038-46 pubmed
  17. MacCarty R, Johnson C, Fletcher J, Wilson L. Occult colorectal polyps on CT colonography: implications for surveillance. AJR Am J Roentgenol. 2006;186:1380-3 pubmed
    ..Differences in the prevalence of occult polyps in various populations might help explain the discordant reported sensitivities for polyp detection in published reports of CTC...
  18. Snover D, Jass J, Fenoglio Preiser C, Batts K. Serrated polyps of the large intestine: a morphologic and molecular review of an evolving concept. Am J Clin Pathol. 2005;124:380-91 pubmed
  19. Sonoshita M, Takaku K, Oshima M, Sugihara K, Taketo M. Cyclooxygenase-2 expression in fibroblasts and endothelial cells of intestinal polyps. Cancer Res. 2002;62:6846-9 pubmed
    ..By immunohistochemical analysis, here we show that the majority of COX-2-expressing cells in the intestinal polyps of Apc(Delta716) mice are fibroblasts and endothelial cells...
  20. Phillips R, Wallace M, Lynch P, Hawk E, Gordon G, Saunders B, et al. A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis. Gut. 2002;50:857-60 pubmed
    ..Their role in the duodenum of these patients is less certain. The disease modifying activity of specific COX-2 inhibitors has not been explored in humans...
  21. Lal G, Ash C, Hay K, Redston M, Kwong E, Hancock B, et al. Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor. Cancer Res. 2001;61:6131-6 pubmed
    ..overexpressed in adenomas and colorectal cancers, and COX-2-specific inhibitors have been shown to inhibit intestinal polyps in Apc(Delta716) mice more effectively than dual COX-1/COX-2 inhibitors such as sulindac...
  22. Mutanen M, Pajari A, Oikarinen S. Beef induces and rye bran prevents the formation of intestinal polyps in Apc(Min) mice: relation to beta-catenin and PKC isozymes. Carcinogenesis. 2000;21:1167-73 pubmed
    ..different grain fibers as well as inulin, polydisperse beta(2-->1) fructan, could affect the formation of intestinal polyps in Apc(Min) mice...
  23. Paulsen J, Elvsaas I, Steffensen I, Alexander J. A fish oil derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl ester suppresses the formation and growth of intestinal polyps in the Min mouse. Carcinogenesis. 1997;18:1905-10 pubmed
    ..8 +/- 0.9) and the crypt multiplicity (1.49 +/- 0.28) in females were reduced by 73% (P = 0.03) and 60% (P = 0.048) with 2.5% of K85, respectively, whereas no significant effect could be observed in the males...
  24. Oshima M, Oshima H, Kitagawa K, Kobayashi M, Itakura C, Taketo M. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc Natl Acad Sci U S A. 1995;92:4482-6 pubmed
    ..It is therefore unlikely that the truncated product interacts directly with the wild-type protein and causes the microadenomas by a dominant negative mechanism...
  25. Song J, Sohn K, Medline A, Ash C, Gallinger S, Kim Y. Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- mice. Cancer Res. 2000;60:3191-9 pubmed
  26. Oshima M, Murai N, Kargman S, Arguello M, Luk P, Kwong E, et al. Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. Cancer Res. 2001;61:1733-40 pubmed
    ..Although homozygote Apc-/- mice are embryonically lethal, the heterozygotes are viable but develop numerous intestinal polyps with loss of Apc heterozygosity within the polyps (M. Oshima et al., Proc. Natl. Acad. Sci...
  27. Huang C, O Brien M, Yang S, Farraye F. Hyperplastic polyps, serrated adenomas, and the serrated polyp neoplasia pathway. Am J Gastroenterol. 2004;99:2242-55 pubmed
  28. Khor T, Hu R, Shen G, Jeong W, Hebbar V, Chen C, et al. Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice. Biopharm Drug Dispos. 2006;27:407-20 pubmed
    ..Recently it was found that SFN could also suppress the growth of intestinal polyps in the ApcMin/+ mouse...
  29. Seno H, Oshima M, Ishikawa T, Oshima H, Takaku K, Chiba T, et al. Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. Cancer Res. 2002;62:506-11 pubmed
  30. Sunayama K, Konno H, Nakamura T, Kashiwabara H, Shoji T, Tsuneyoshi T, et al. The role of cyclooxygenase-2 (COX-2) in two different morphological stages of intestinal polyps in APC(Delta474) knockout mice. Carcinogenesis. 2002;23:1351-9 pubmed
  31. Vernillo R, Lorenzi B, Banducci T, Minacci C, Vindigni C, Lucenti Fei A, et al. Immunohistochemical expression of p53 and Ki67 in colorectal adenomas and prediction of malignancy and development of new polyps. Int J Biol Markers. 2008;23:89-95 pubmed
    ..The expression of biological markers may be in future added to the currently examined features of polyps; however, further studies are needed to better define their predictive value...
  32. Shahid M, Buchner A, Gomez V, Krishna M, Woodward T, Raimondo M, et al. Diagnostic accuracy of probe-based confocal laser endomicroscopy and narrow band imaging in detection of dysplasia in duodenal polyps. J Clin Gastroenterol. 2012;46:382-9 pubmed publisher
    ..To estimate the accuracy of probe-based confocal laser endomicroscopy (pCLE) and narrow band imaging (NBI), individually and in combination, for classification of duodenal polyps...
  33. Barut F, Kandemir N, Karakaya K, Kökten N, Ozdamar S. Primary intestinal diffuse large B-cell lymphoma forming multiple lymphomatous polyposis. Turk J Gastroenterol. 2011;22:324-8 pubmed
    ..The diagnosis of the case was diffuse large B-cell lymphoma.The possibility of the presence of this disorder, although rare, is emphasized here for patients applying to the hospital with the signs and symptoms of Crohn's disease...
  34. Abbass R, Rigaux J, Al Kawas F. Nonampullary duodenal polyps: characteristics and endoscopic management. Gastrointest Endosc. 2010;71:754-9 pubmed publisher
    ..Guidelines for endoscopic resection and surveillance of nonampullary duodenal (NAD) polyps are still not well-defined...
  35. Buchanan F, Holla V, Katkuri S, Matta P, DuBois R. Targeting cyclooxygenase-2 and the epidermal growth factor receptor for the prevention and treatment of intestinal cancer. Cancer Res. 2007;67:9380-8 pubmed
    ..COX-2) and the epidermal growth factor receptor (EGFR) in the development and progression of intestinal polyps and cancers...
  36. Plum N, May A, Manner H, Ell C. [Peutz-Jeghers syndrome: endoscopic detection and treatment of small bowel polyps by double-balloon enteroscopy]. Z Gastroenterol. 2007;45:1049-55 pubmed
    ..With the introduction of double-balloon enteroscopy (DBE), we now have not only an improved diagnostic tool but also a non-surgical treatment option...
  37. Baudendistel T, Haase A, Fitzgerald F. Clinical problem-solving. The leading diagnosis--a 23-year-old black woman presented to the emergency department with diffuse, colicky abdominal pain of 1 hour's duration. N Engl J Med. 2007;357:2389-93 pubmed
  38. Long Y, Sánchez Espiridión B, Lin M, White L, Mishra L, Raju G, et al. Global and targeted serum metabolic profiling of colorectal cancer progression. Cancer. 2017;123:4066-4074 pubmed publisher
    ..The aim of this study was to identify biomarkers of progression to CRC through metabolomic profiling of human serum samples with a multistage approach...
  39. Matsushita M, Shimatani M, Uchida K, Okazaki K. Safe endoscopic polypectomy of jejunal polyps with a detachable snare during double balloon enteroscopy. Gut. 2007;56:1324; author reply 1324-5 pubmed
  40. Zaman S, Mistry P, Hendrickse C, Bowley D. Cloacogenic polyps in an adolescent: a rare cause of rectal bleeding. J Pediatr Surg. 2013;48:e5-7 pubmed publisher
    ..They should be given diagnostic consideration in patients presenting with symptoms of rectal bleeding, tenesmus, and altered bowel habits. ..
  41. Kovács M, Pak P, Pak G, Feher J. [Screening and surveillance for hereditary polyposis and non-polyposis syndromes with capsule endoscopy]. Orv Hetil. 2008;149:639-44 pubmed publisher
    ..Nevertheless, determination of size and location of polyps has become more problematic when evaluating the test results...
  42. Wu L, Han T, Fan X, Pan W, Wang C, Zhong H, et al. Serum C-reactive protein as a possible marker to predict delayed hemorrhage after colonoscopic polypectomy. Med Sci Monit. 2012;18:CR480-485 pubmed
    ..This research aimed to study risk prediction of delayed post-polypectomy hemorrhage using serum C-reactive protein (CRP) level as a marker...
  43. Mandir N, Goodlad R. Conjugated linoleic acids differentially alter polyp number and diameter in the Apc(min/+) mouse model of intestinal cancer. Cell Prolif. 2008;41:279-91 pubmed publisher
    ..Dietary conjugated linoleic acids (CLA) have had many health benefits claimed for them, including antineoplastic actions...
  44. El Demellawy D, Shokry P, Ing A, Khalifa M. Polypoid gastrointestinal stromal tumor of small bowel metastasizing to mesenteric lymph nodes: a case report. Pathol Res Pract. 2008;204:197-201 pubmed
    ..The presented case has three unusual features, as the tumor was grossly pedunculated, microscopically pleomorphic, and featured mesenteric lymph node metastasis at the time of diagnosis...
  45. Rodriguez Jurado R, Morales S. Polypoid arteriovenous malformation in the jejunum of a child that mimics intussusception. J Pediatr Surg. 2010;45:E9-12 pubmed publisher
    ..A retrospective computed tomographic scan 3-dimensional angiographic reconstruction demonstrated that this may be a diagnostic characteristic. Clinical and morphologic comparisons with previously reported cases were discussed...
  46. Kunz A, Riera D, Hickey P. Case of Clostridium perfringens bacteremia after routine colonoscopy and polypectomy. Anaerobe. 2009;15:195-6 pubmed publisher
    ..Therefore, for patients with a history of polypectomy and new onset fever, anaerobic infections should be considered and empiric antibiotic therapy should include coverage for these organisms...
  47. D Costa G, Agale S, Pandya B, Surase S. Peutz-Jegher's syndrome with ovarian serous cystadenoma: an unusual association. Indian J Pathol Microbiol. 2007;50:768-70 pubmed
    ..There was an associated unilateral ovarian cystadenoma which is a rare association and which highlights the importance of a gynaecologic examination in female patients with Peutz-Jegher's syndrome...
  48. Niv Y. Gender medicine in gastroenterology. Isr Med Assoc J. 2011;13:244-6 pubmed
    ..In this review I will describe some of the evidence for gender differences in gastrointestinal diseases. Gender medicine and its application for gastroenterology is a new field and one warranting research...
  49. Haji A, Ryan S, Bjarnason I, Papagrigoriadis S. High-frequency mini-probe ultrasound as a useful adjunct in the management of patients with malignant colorectal polyps. Colorectal Dis. 2013;15:304-8 pubmed publisher
    ..This study assessed 12- and 20-MHz colonoscopic ultrasound to evaluate the presence of residual disease and local lymph nodes...
  50. Weigt J, Zimmermann L, Monkemuller K, Malfertheiner P. Acute pancreatitis after argon plasma coagulation of duodenal polyps in a patient with familial adenomatous polyposis. Endoscopy. 2007;39 Suppl 1:E278 pubmed
  51. Kuiper R, de Jong J, Kneepkens C. [There is something coming out of the anus of my child]. Ned Tijdschr Geneeskd. 2011;155:A2735 pubmed
    ..The first patient recovered after laxative therapy, the second after polypectomy, and in the third patient, the haemorrhoid persisted, despite laxative therapy and physiotherapy...
  52. Hashimoto T, Yamashita S, Yoshida H, Taniguchi H, Ushijima T, Yamada T, et al. WNT Pathway Gene Mutations Are Associated With the Presence of Dysplasia in Colorectal Sessile Serrated Adenoma/Polyps. Am J Surg Pathol. 2017;41:1188-1197 pubmed publisher
    ..These results suggest that WNT pathway gene mutations are involved in the development of dysplasia in SSA/Ps and that MLH1-deficient and MLH1-retained SSA/Ps with dysplasia exhibit distinct mutation profiles of WNT pathway genes...
  53. Shaheen I, Fitzpatrick M, Brownlee K, Bhuskute N, Elliott M, Powis M, et al. Bilateral progressive cystic nephroma in a 9-month-old male infant requiring renal replacement therapy. Pediatr Nephrol. 2010;25:1755-8 pubmed publisher
    ..and was found to have a triad of bilateral cystic nephroma, pleuropulmonary blastoma (PPB) and juvenile intestinal polyps. There have been three previous reported cases of patients with the same associated diagnoses...