splenomegaly

Summary

Summary: Enlargement of the spleen.

Top Publications

  1. Foretz M, Hebrard S, Guihard S, Leclerc J, Do Cruzeiro M, Hamard G, et al. The AMPK?1 subunit plays an essential role in erythrocyte membrane elasticity, and its genetic inactivation induces splenomegaly and anemia. FASEB J. 2011;25:337-47 pubmed publisher
    ..Prkag1(-/-) mice displayed splenomegaly and iron accumulation due to compensatory splenic erythropoiesis and erythrophagocytosis...
  2. Lavrenkov K, Krepel Volsky S, Levi I, Ariad S. Low dose palliative radiotherapy for splenomegaly in hematologic disorders. Leuk Lymphoma. 2012;53:430-4 pubmed publisher
    b>Splenomegaly (SM) is a common complication in hematologic disorders often associated with hypersplenism, and may cause pain, epigastric discomfort and variable systemic effects due to cytopenias...
  3. Cen O, Longnecker R. Rapamycin reverses splenomegaly and inhibits tumor development in a transgenic model of Epstein-Barr virus-related Burkitt's lymphoma. Mol Cancer Ther. 2011;10:679-86 pubmed publisher
    ..the PI3K/Akt/mTOR pathway, we tested the therapeutic efficacy of mTOR inhibitor rapamycin on the tumors and splenomegaly in these double transgenic mice (Tg6/?-MYC)...
  4. Chaves L, Taleo G, Kalkoa M, Kaneko A. Spleen rates in children: an old and new surveillance tool for malaria elimination initiatives in island settings. Trans R Soc Trop Med Hyg. 2011;105:226-31 pubmed publisher
    ..Finally, results highlight the value of measuring spleen sizes to rapidly assess the impact of intervention packages aimed at malaria elimination or control...
  5. Harrison C, Kiladjian J, Al Ali H, Gisslinger H, Waltzman R, Stalbovskaya V, et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med. 2012;366:787-98 pubmed publisher
    ..Treatment options for myelofibrosis are limited. We evaluated the efficacy and safety of ruxolitinib, a potent and selective Janus kinase (JAK) 1 and 2 inhibitor, as compared with the best available therapy, in patients with myelofibrosis...
  6. Hiramoto K, Kuroki M, Nakano E, Kanno N, Matsumura Y, Miura A, et al. [Successful management with partial splenic embolization (PSE) of splenomegaly and thrombocytopenia caused by oxaliplatin-based chemotherapy for advanced colorectal cancer]. Gan To Kagaku Ryoho. 2011;38:835-9 pubmed
    ..which received chemotherapy, in which partial splenic embolization (PSE) had been effective for controlling splenomegaly and thrombocytopenia. Case 1: A 50-year-old man presented with bloody urine and bloody stool...
  7. Kriz J, Micke O, Bruns F, Haverkamp U, Mücke R, Schäfer U, et al. Radiotherapy of splenomegaly : a palliative treatment option for a benign phenomenon in malignant diseases. Strahlenther Onkol. 2011;187:221-4 pubmed publisher
    Since the 20(th) century, radiotherapy (RT) has been used for treatment of symptomatic splenomegaly (SM). SM occurs in association with hematologic disorders...
  8. Verstovsek S, Mesa R, Gotlib J, Levy R, Gupta V, DiPersio J, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med. 2012;366:799-807 pubmed publisher
    ..Ruxolitinib, a selective inhibitor of Janus kinase (JAK) 1 and 2, has clinically significant activity in myelofibrosis...
  9. Randhawa J, Ostojic A, Vrhovac R, Atallah E, Verstovsek S. Splenomegaly in myelofibrosis--new options for therapy and the therapeutic potential of Janus kinase 2 inhibitors. J Hematol Oncol. 2012;5:43 pubmed publisher
    b>Splenomegaly is a common sign of primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (post-PV MF), and post-essential thrombocythemia myelofibrosis (post-ET MF) that is associated with bothersome symptoms, which have a ..

Scientific Experts

More Information

Publications62

  1. Dargart J, Fish K, Gordon L, Longnecker R, Cen O. Dasatinib therapy results in decreased B cell proliferation, splenomegaly, and tumor growth in a murine model of lymphoma expressing Myc and Epstein-Barr virus LMP2A. Antiviral Res. 2012;95:49-56 pubmed publisher
    ..LMP2A/?-MYC double transgenic mice develop splenomegaly and cervical lymphomas starting at 8 weeks of age...
  2. Kim J, Lee E, Jeon K, Choi H, Lim H, Kim S, et al. Role of BI-1 (TEGT)-mediated ERK1/2 activation in mitochondria-mediated apoptosis and splenomegaly in BI-1 transgenic mice. Biochim Biophys Acta. 2012;1823:876-88 pubmed publisher
    ..Interestingly, we found that BI-1 TG mice showed splenomegaly and abnormal megakaryopoiesis...
  3. A Elgayoum S, El Rayah E, Giha H. Validation of PCR for detection and characterization of parasitaemia in massive splenomegaly attributed clinically to malaria infection. Diagn Microbiol Infect Dis. 2011;70:207-12 pubmed publisher
    In this study, 101 patients with massive splenomegaly (MS) and 41 with moderate splenomegaly (MoS) from Kassala, Eastern Sudan, were included...
  4. Choi S, Kang C, Hwang H, Lee W. Reappraisal of anterior approach to laparoscopic splenectomy: technical feasibility and its clinical application. Surg Laparosc Endosc Percutan Tech. 2011;21:353-7 pubmed publisher
    ..The presented technique of modified laparoscopic splenectomy seems to be a feasible, easy, and safe procedure. It is also thought that surgical indication could be extended even to the splenomegaly by this technique.
  5. Logan L, Jacobs N, McAuley J, Weinstein R, Anderson E. A multicenter retrospective study of childhood brucellosis in Chicago, Illinois from 1986 to 2008. Int J Infect Dis. 2011;15:e812-7 pubmed publisher
    ..To determine risk factors in children for the acquisition of Brucella, clinical presentation, treatment, and disease outcomes...
  6. Zhou J, Wu Z, Cai Y, Wang Y, Peng B. The feasibility and safety of laparoscopic splenectomy for massive splenomegaly: a comparative study. J Surg Res. 2011;171:e55-60 pubmed publisher
    Laparoscopic splenectomy used for massive splenomegaly is still controversial. The purpose of our current study was to identify the feasibility and safety of laparoscopic splenectomy for massive splenomegaly.
  7. Jackson A, Nanton M, O Donnell H, Akue A, McSorley S. Innate immune activation during Salmonella infection initiates extramedullary erythropoiesis and splenomegaly. J Immunol. 2010;185:6198-204 pubmed publisher
    Systemic Salmonella infection commonly induces prolonged splenomegaly in murine or human hosts...
  8. Swanson T, Meneghetti A, Sampath S, Connors J, Panton O. Hand-assisted laparoscopic splenectomy versus open splenectomy for massive splenomegaly: 20-year experience at a Canadian centre. Can J Surg. 2011;54:189-93 pubmed publisher
    ..Concerns regarding a purely laparoscopic splenectomy for massive splenomegaly (> 20 cm) arise from potentially longer operative times, higher conversion rates and increased blood loss...
  9. Jaroensuk J, Stoesser N, Leimanis M, Jittamala P, White N, Nosten F, et al. Treatment of suspected hyper-reactive malarial splenomegaly (HMS) in pregnancy with mefloquine. Am J Trop Med Hyg. 2014;90:609-11 pubmed publisher
    ..There are few data on hyper-reactive malarial splenomegaly, an aberrant immunological response to chronic or recurrent malaria in pregnancy...
  10. Miura K, Nakano H, Sakurai J, Kobayashi S, Koizumi S, Arai T, et al. Splenomegaly in FOLFOX-naïve stage IV or recurrent colorectal cancer patients due to chemotherapy-associated hepatotoxicity can be predicted by the aspartate aminotransferase to platelet ratio before chemotherapy. Int J Clin Oncol. 2011;16:257-63 pubmed publisher
    Chemotherapy-associated hepatotoxicity is a common cause of postoperative complications after major hepatectomy. Splenomegaly may indicate portal hypertension due to chemotherapy...
  11. Garchow B, Bartulos Encinas O, Leung Y, Tsao P, Eisenberg R, Caricchio R, et al. Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice. EMBO Mol Med. 2011;3:605-15 pubmed publisher
    ..B and T cells is up-regulated and that in vivo silencing of miR-21 using a tiny seed-targeting LNA reversed splenomegaly, one of the cardinal manifestations of autoimmunity in B6...
  12. Wu Z, Zhou J, Pankaj P, Peng B. Laparoscopic and open splenectomy for splenomegaly secondary to liver cirrhosis: an evaluation of immunity. Surg Endosc. 2012;26:3557-64 pubmed publisher
    We sought to investigate the perioperative inflammatory response and immunological function of patients with portal hypertension-induced splenomegaly who underwent laparoscopic (LS) or open splenectomy (OS).
  13. Wilson S, Vennervald B, Kadzo H, Ireri E, Amaganga C, Booth M, et al. Hepatosplenomegaly in Kenyan schoolchildren: exacerbation by concurrent chronic exposure to malaria and Schistosoma mansoni infection. Trop Med Int Health. 2007;12:1442-9 pubmed
    ..We investigated the role of chronic malaria in childhood hepatosplenomegaly in the presence and absence of concurrent S. mansoni infection...
  14. Halfdanarson T, Walker J, Litzow M, Hanson C. Severe vitamin B12 deficiency resulting in pancytopenia, splenomegaly and leukoerythroblastosis. Eur J Haematol. 2008;80:448-51 pubmed publisher
    Deficiency of vitamin B12 is a well known cause of megaloblastic anemia and pancytopenia. Splenomegaly and leukoerythroblastosis are much less well known manifestations of B12 deficiency...
  15. Hutcheson J, Scatizzi J, Siddiqui A, Haines G, Wu T, Li Q, et al. Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity. Immunity. 2008;28:206-17 pubmed publisher
    ..These data demonstrate that dysregulation of the Bcl-2 or Fas pathways can alter the function of APCs, thereby leading to SLE pathogenesis...
  16. Osorio J, Watkins J, Strange C, Jenrette J. Radiation therapy for palliation of Eisenmenger's syndrome-associated painful splenomegaly. Radiat Med. 2008;26:84-7 pubmed publisher
    Painful splenomegaly has a clinical presentation that is often associated with myeloproliferative disorders, such as acute or chronic lymphoblastic or myelogenous leukemia...
  17. Foller M, Feil S, Ghoreschi K, Koka S, Gerling A, Thunemann M, et al. Anemia and splenomegaly in cGKI-deficient mice. Proc Natl Acad Sci U S A. 2008;105:6771-6 pubmed publisher
    ..By the age of 10 weeks, cGKI-deficient mice exhibited pronounced anemia and splenomegaly. Compared with control mice, the cGKI mutants had significantly lower red blood cell count, packed cell volume, ..
  18. Buchanan G. Thrombocytopenia during childhood: what the pediatrician needs to know. Pediatr Rev. 2005;26:401-9 pubmed
  19. Angitapalli R, Litwin A, Kumar P, Nasser E, Lombardo J, Mashtare T, et al. Adjuvant FOLFOX chemotherapy and splenomegaly in patients with stages II-III colorectal cancer. Oncology. 2009;76:363-8 pubmed publisher
    ..We conducted a retrospective study to assess the effects of adjuvant FOLFOX chemotherapy on the splenic index (SI) as a surrogate marker for portal hypertension...
  20. Mesa R. How I treat symptomatic splenomegaly in patients with myelofibrosis. Blood. 2009;113:5394-400 pubmed publisher
    ..MF patients have a range of debilitating disease manifestations (eg, massive splenomegaly, cytopenias, constitutional symptoms, and transformation to a treatment-refractory blast phase)...
  21. Ruzagira E, Abaasa A, Levin J, Bahemuka U, Bwanika A, Amornkul P, et al. Haematological and biochemistry laboratory abnormalities associated with splenomegaly in asymptomatic adults in Masaka, Uganda: implications for HIV biomedical prevention trials. Trop Med Int Health. 2010;15:105-12 pubmed publisher
    To assess the degree of haematological and biochemistry abnormalities associated with splenomegaly in asymptomatic adults in order to determine whether they may be eligible for inclusion in HIV biomedical prevention trials.
  22. Grgic I, Kaistha B, Paschen S, Kaistha A, Busch C, Si H, et al. Disruption of the Gardos channel (KCa3.1) in mice causes subtle erythrocyte macrocytosis and progressive splenomegaly. Pflugers Arch. 2009;458:291-302 pubmed publisher
    ..Deformability to increasing shear stress was unchanged. Strikingly, K(Ca)3.1(-/-)-mice developed progressive splenomegaly which was considerable ( approximately 200% of controls) in the >6-month-old mice and was paralleled by ..
  23. Baffert F, Regnier C, De Pover A, Pissot Soldermann C, Tavares G, Blasco F, et al. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther. 2010;9:1945-55 pubmed publisher
    ..The inhibitor was efficacious in suppressing leukemic cell spreading and splenomegaly in a Ba/F3 JAK2(V617F) cell-driven mouse mechanistic model...
  24. Booker C, White K. Benzo(a)pyrene-induced anemia and splenomegaly in NZB/WF1 mice. Food Chem Toxicol. 2005;43:1423-31 pubmed
    ..possibly caused by BaP exposure, or chemical-induced hemolysis, perhaps contributed to by erythrocyte fragility inherited from a parent strain, NZB, which spontaneously develops autoimmune hemolytic anemia and subsequent splenomegaly.
  25. Poala S, Bisogno G, Colombatti R. Thrombocytopenia and splenomegaly: an unusual presentation of congenital hepatic fibrosis. Orphanet J Rare Dis. 2010;5:4 pubmed publisher
    ..We describe the first case of CHF presenting in an otherwise healthy child, with thrombocytopenia and splenomegaly as the only manifestations of the disease.
  26. Singh R. Tinospora cordifolia as an adjuvant drug in the treatment of hyper-reactive malarious splenomegaly--case reports. J Vector Borne Dis. 2005;42:36-8 pubmed
    ..activity along with chloroquine was studied in the treatment of three cases of hyper-reactive malarious splenomegaly in District Hospital, Daltonganj town, Jharkhand, India...
  27. Arumugakani G, Wood P, Carter C. Frequency of Treg cells is reduced in CVID patients with autoimmunity and splenomegaly and is associated with expanded CD21lo B lymphocytes. J Clin Immunol. 2010;30:292-300 pubmed publisher
    ..The study was designed to evaluate the role of T regulatory (Treg) cells in common variable immunodeficiency (CVID) patients with autoimmunity...
  28. Allam M, Alkadarou T, Ahmed B, Elkhair I, Alansary E, Ibrahim M, et al. Hyper-reactive Malarial Splenomegaly (HMS) in malaria endemic area in Eastern Sudan. Acta Trop. 2008;105:196-9 pubmed
    Hyper-reactive Malarial Splenomegaly (HMS) is massive enlargement of the spleen resulting from abnormal immune response to repeated attacks of malaria...
  29. Ohta M, Nishizaki T, Matsumoto T, Shimabukuro R, Sasaki A, Shibata K, et al. Analysis of risk factors for massive intraoperative bleeding during laparoscopic splenectomy. J Hepatobiliary Pancreat Surg. 2005;12:433-7 pubmed
    ..Laparoscopic splenectomy is occasionally converted to open surgery due to massive intraoperative bleeding. The aim of this study was to identify the risk factors for massive bleeding during laparoscopic splenectomy...
  30. Ziegler J. Hyper-reactive malarial splenomegaly. Am J Trop Med Hyg. 2008;78:186-7 pubmed
  31. Mothe B, Lopez Contreras J, Torres O, Munoz C, Domingo P, Gurgui M. A case of hyper-reactive malarial splenomegaly. The role of rapid antigen-detecting and PCR-based tests. Infection. 2008;36:167-9 pubmed
    Hyper-reactive malarial splenomegaly (HMS) - originally referred to as tropical splenomegaly syndrome - is characterized by a massive splenomegaly, high titres of anti-malarial antibodies and polyclonal IgM hypergammaglobulinemia...
  32. Fagundes E, Ferreira A, Roquete M, Penna F, Goulart E, Figueiredo Filho P, et al. Clinical and laboratory predictors of esophageal varices in children and adolescents with portal hypertension syndrome. J Pediatr Gastroenterol Nutr. 2008;46:178-83 pubmed publisher
    ..To determine the clinical and laboratory parameters that may predict the presence of esophageal varices in children and adolescents with portal hypertension...
  33. Chan C, Abe M, Hashimoto N, Hao C, Williams I, Liu X, et al. Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome. Proc Natl Acad Sci U S A. 2009;106:468-73 pubmed publisher
    ..Further, AEP-null mice display lower natural killer cell activity, but none of the major cytokines is substantially abnormal. These results indicate that AEP might be a previously unrecognized component in HLH pathophysiology...
  34. Martínez Trillos A, Gaya A, Maffioli M, Arellano Rodrigo E, Calvo X, Díaz Beyá M, et al. Efficacy and tolerability of hydroxyurea in the treatment of the hyperproliferative manifestations of myelofibrosis: results in 40 patients. Ann Hematol. 2010;89:1233-7 pubmed publisher
    ..2 months (range 0-141.7). Reasons for treatment were constitutional symptoms (55%), symptomatic splenomegaly (45%), thrombocytosis (40%), leukocytosis (28%), pruritus (10%), and bone pain (8%)...
  35. Oliveira J, Valbuena C, Baldaia Moreira A, Fonseca E, Soares C, Leao Teles E, et al. Splenomegaly, hypersplenism and peripheral blood cytopaenias in patients with classical Anderson-Fabry disease. Virchows Arch. 2008;453:291-300 pubmed publisher
    A 39-year-old male with classical Anderson-Fabry disease (AFD) and long-standing idiopathic splenomegaly, who had been on haemodialysis since the age of 24, was splenectomised for symptomatic pancytopaenia...
  36. Vivas L, O Dea K, Noya O, Pabon R, Magris M, Botto C, et al. Hyperreactive malarial splenomegaly is associated with low levels of antibodies against red blood cell and Plasmodium falciparum derived glycolipids in Yanomami Amerindians from Venezuela. Acta Trop. 2008;105:207-14 pubmed publisher
    The immunological basis of the aberrant immune response in hyperreactive malarial splenomegaly (HMS) is poorly understood, but believed to be associated with polyclonal B cell activation by an unidentified malaria mitogen, leading to ..
  37. Trizzino A, Farruggia P, Russo D, D Angelo P, Tropia S, Benigno V, et al. Congenital hepatic fibrosis: a very uncommon cause of pancytopenia in children. J Pediatr Hematol Oncol. 2005;27:567-8 pubmed
    ..The authors report an unusual case of ARPKD presenting with hepatosplenomegaly and cytopenia mimicking acute leukemia...
  38. Dupré S, Hunter K. Murine mammary carcinoma 4T1 induces a leukemoid reaction with splenomegaly: association with tumor-derived growth factors. Exp Mol Pathol. 2007;82:12-24 pubmed
    A leukemoid reaction with granulocytosis and splenomegaly has been observed in animals and humans with a variety of tumors...
  39. Mejias M, Garcia Pras E, Gallego J, Mendez R, Bosch J, Fernandez M. Relevance of the mTOR signaling pathway in the pathophysiology of splenomegaly in rats with chronic portal hypertension. J Hepatol. 2010;52:529-39 pubmed publisher
    b>Splenomegaly is a frequent hallmark of portal hypertension that, in some cases, can be very prominent and cause symptoms like abdominal pain, splenic infarction, and cytopenia...
  40. Abdel Aziz I, Oster N, Stich A, Coulibaly B, Guigemdé W, Wickert H, et al. Association of Plasmodium falciparum isolates encoding the p. Falciparum chloroquine resistance transporter gene K76T polymorphism with anemia and splenomegaly, but not with multiple infections. Am J Trop Med Hyg. 2005;72:252-5 pubmed
    ..regression analysis showed that pfcrt K76T-carrying isolates are significantly more likely to cause anemia and splenomegaly. Furthermore, we found that infections with P...
  41. Barosi G, Bergamaschi G, Marchetti M, Vannucchi A, Guglielmelli P, Antonioli E, et al. JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis. Blood. 2007;110:4030-6 pubmed
    ..Adjusting for conventional risk factors, V617F mutation independently predicted the evolution toward large splenomegaly, need of splenectomy, and leukemic transformation...
  42. Eremeeva M, Gerns H, Lydy S, Goo J, Ryan E, Mathew S, et al. Bacteremia, fever, and splenomegaly caused by a newly recognized bartonella species. N Engl J Med. 2007;356:2381-7 pubmed
    ..We describe a patient who had fever and splenomegaly after traveling to Peru and also had bacteremia from an organism that resembled Bartonella bacilliformis, the ..
  43. Singh R. Hyperreactive malarial splenomegaly in expatriates. Travel Med Infect Dis. 2007;5:24-9 pubmed
    Hyperreactive malarial splenomegaly, one of the major causes of splenomegaly in tropics, has been often reported in expatriates of non-tropical settings...
  44. Putz G, Rosner A, Nuesslein I, Schmitz N, Buchholz F. AML1 deletion in adult mice causes splenomegaly and lymphomas. Oncogene. 2006;25:929-39 pubmed
    ..Metastatic lymphomas to the liver and the meninges were observed. Mice also developed splenomegaly with an expansion of the myeloid compartment. Increased Howell-Jolly body counts indicated splenic hypofunction...
  45. Aessopos A, Farmakis D, Deftereos S, Tsironi M, Polonifi A, Moyssakis I, et al. Cardiovascular effects of splenomegaly and splenectomy in beta-thalassemia. Ann Hematol. 2005;84:353-7 pubmed
    b>Splenomegaly is common in beta-thalassemia, bearing some particular hemodynamic features, while splenectomy is an established therapeutic intervention in these patients...
  46. Ziari M, Sonpavde G, Shen S, Zhai J, Teh B, Lerner S. Patients with unusual bladder malignancies and a rare cause of splenomegaly. Case 2. Rhabdomyosarcoma of the urinary bladder in an adult. J Clin Oncol. 2005;23:4459-60 pubmed
  47. De Franceschi L, Sada S, Andreoli A, Angheben A, Marocco S, Bisoffi Z. Sickle cell disease and hyperreactive malarial splenomegaly (HMS) in young immigrants from Africa. Blood. 2005;106:4415-7 pubmed
  48. Tefferi A, Cortes J, Verstovsek S, Mesa R, Thomas D, Lasho T, et al. Lenalidomide therapy in myelofibrosis with myeloid metaplasia. Blood. 2006;108:1158-64 pubmed
    ..Overall response rates were 22% for anemia, 33% for splenomegaly, and 50% for thrombocytopenia...
  49. Subhasis R, Rajiv C, Kumar S, Kumar A, Kumar P. Surgical treatment of massive splenomegaly and severe hypersplenism secondary to extrahepatic portal venous obstruction in children. Surg Today. 2007;37:19-23 pubmed
    Massive splenomegaly with severe hypersplenism can occur as a late complication of portal hypertension (PH) caused by extrahepatic portal venous obstruction (EHPVO) in children...
  50. Wilson S, Jones F, Mwatha J, Kimani G, Booth M, Kariuki H, et al. Hepatosplenomegaly is associated with low regulatory and Th2 responses to schistosome antigens in childhood schistosomiasis and malaria coinfection. Infect Immun. 2008;76:2212-8 pubmed publisher
  51. Vennervald B, Booth M, Butterworth A, Kariuki H, Kadzo H, Ireri E, et al. Regression of hepatosplenomegaly in Kenyan school-aged children after praziquantel treatment and three years of greatly reduced exposure to Schistosoma mansoni. Trans R Soc Trop Med Hyg. 2005;99:150-60 pubmed
    ..The prevalence of hard spleens, and the magnitude of clinically assessed splenomegaly along the mid-axillary and mid-clavicular lines decreased monotonically over time, independently of age, ..
  52. Dalton J, Maroof A, Owens B, Narang P, Johnson K, Brown N, et al. Inhibition of receptor tyrosine kinases restores immunocompetence and improves immune-dependent chemotherapy against experimental leishmaniasis in mice. J Clin Invest. 2010;120:1204-16 pubmed publisher
    ..of the broad-spectrum RTKI sunitinib maleate (Sm) blocked the vascular remodeling and progressive splenomegaly associated with experimental visceral leishmaniasis...
  53. Chang Y, Kim Y, Min K, Kim Y, Seong Y, Cho S. Conjugation of 3' hexameric deoxyriboguanosine run to phosphodiester CpG oligodeoxynucleotides can inhibit allergen-specific IgE synthesis with less risk of splenomegaly. J Allergy Clin Immunol. 2005;116:1388-90 pubmed