hyperventilation

Summary

Summary: A pulmonary ventilation rate faster than is metabolically necessary for the exchange of gases. It is the result of an increased frequency of breathing, an increased tidal volume, or a combination of both. It causes an excess intake of oxygen and the blowing off of carbon dioxide.

Top Publications

  1. Schlünzen L, Vafaee M, Juul N, Cold G. Regional cerebral blood flow responses to hyperventilation during sevoflurane anaesthesia studied with PET. Acta Anaesthesiol Scand. 2010;54:610-5 pubmed publisher
    ..We evaluated the effects of hyperventilation on regional cerebral blood flow (rCBF) in healthy volunteers during sevoflurane anaesthesia measured with ..
  2. van Balkom I, Vuijk P, Franssens M, Hoek H, Hennekam R. Development, cognition, and behaviour in Pitt-Hopkins syndrome. Dev Med Child Neurol. 2012;54:925-31 pubmed publisher
    ..The aim of the study was to collect detailed data on behavioural, adaptive, and psychological functioning in 10 individuals with Pitt-Hopkins syndrome (PTHS), with specific attention to manifestations of autism spectrum disorder (ASD)...
  3. Freed A, Wang Y, McCulloch S, Myers T, Suzuki R. Mucosal injury and eicosanoid kinetics during hyperventilation-induced bronchoconstriction. J Appl Physiol (1985). 1999;87:1724-33 pubmed
    Bronchoalveolar lavage (BAL) of canine peripheral airways was performed at various times after hyperventilation, and BAL fluid (BALF) cell and mediator data were used to evaluate two hypotheses: 1) hyperventilation-induced mucosal injury ..
  4. Stavropoulos D, MacGregor D, Yoon G. Mosaic microdeletion 18q21 as a cause of mental retardation. Eur J Med Genet. 2010;53:396-9 pubmed publisher
  5. CISSE B, Caton M, Lehner M, Maeda T, Scheu S, Locksley R, et al. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell. 2008;135:37-48 pubmed publisher
    ..These results identify E2-2 as a specific transcriptional regulator of the PDC lineage in mice and humans and reveal a key function of E proteins in the innate immune system. ..
  6. de Pontual L, Mathieu Y, Golzio C, Rio M, Malan V, Boddaert N, et al. Mutational, functional, and expression studies of the TCF4 gene in Pitt-Hopkins syndrome. Hum Mutat. 2009;30:669-76 pubmed publisher
    ..In summary, we further delineate an underdiagnosed mental retardation syndrome, highlighting TCF4 function during development and facilitating diagnosis within the first year of life. ..
  7. van de Borne P, Mezzetti S, Montano N, Narkiewicz K, Degaute J, Somers V. Hyperventilation alters arterial baroreflex control of heart rate and muscle sympathetic nerve activity. Am J Physiol Heart Circ Physiol. 2000;279:H536-41 pubmed
    ..We studied in 11 resting normal subjects the effects of sustained isocapnic hyperventilation on arterial baroreceptor sensitivity, determined as the alpha index between oscillations in systolic BP (SBP) ..
  8. Brummel N, Mastronarde J, Rittinger D, Philips G, Parsons J. The clinical utility of eucapnic voluntary hyperventilation testing for the diagnosis of exercise-induced bronchospasm. J Asthma. 2009;46:683-6 pubmed publisher
    ..Eucapnic voluntary hyperventilation (EVH) has been used to diagnose EIB in elite athletes and in research settings...
  9. Kippelen P, Larsson J, Anderson S, Brannan J, Delin I, Dahlen B, et al. Acute effects of beclomethasone on hyperpnea-induced bronchoconstriction. Med Sci Sports Exerc. 2010;42:273-80 pubmed publisher
    ..This effect was associated with decreased excretion of urinary mediators, suggesting that BDP blunted the mast cell activation. ..

More Information

Publications74

  1. Ghosh P, Friedman N, Ghosh D. Pitt-Hopkins syndrome in a boy with Charcot Marie Tooth disease type 1A: a rare co-occurrence of 2 genetic disorders. J Child Neurol. 2012;27:1602-6 pubmed publisher
    Pitt-Hopkins syndrome is characterized by marked intellectual impairment, hyperventilation episodes, and dysmorphic facial features...
  2. Brockschmidt A, Todt U, Ryu S, Hoischen A, Landwehr C, Birnbaum S, et al. Severe mental retardation with breathing abnormalities (Pitt-Hopkins syndrome) is caused by haploinsufficiency of the neuronal bHLH transcription factor TCF4. Hum Mol Genet. 2007;16:1488-94 pubmed
    ..and mental retardation including absent language development, a characteristic facial gestalt and episodes of hyperventilation. We report on a female patient with PHS showing severe mental retardation with absent speech, pronounced ..
  3. Whalen S, Heron D, Gaillon T, Moldovan O, Rossi M, Devillard F, et al. Novel comprehensive diagnostic strategy in Pitt-Hopkins syndrome: clinical score and further delineation of the TCF4 mutational spectrum. Hum Mutat. 2012;33:64-72 pubmed publisher
    ..In this study, we have summarized the current knowledge of TCF4 molecular pathology, reported all the mutations in the TCF4 database (http://www.LOVD.nl/TCF4), and present a novel and comprehensive diagnostic strategy for PTHS...
  4. Forrest M, Chapman R, Doyle A, Tinsley C, Waite A, Blake D. Functional analysis of TCF4 missense mutations that cause Pitt-Hopkins syndrome. Hum Mutat. 2012;33:1676-86 pubmed publisher
    ..rare developmental disorder associated with severe mental retardation, facial abnormalities, and intermittent hyperventilation. Autosomal dominant PTHS is caused by mutations in the transcription factor 4 (TCF4) gene, whereas NRXN1 and ..
  5. Adachi Y, Sano H, Doi M, Sato S. Central neurogenic hyperventilation treated with intravenous fentanyl followed by transdermal application. J Anesth. 2007;21:417-9 pubmed
    Central neurogenic hyperventilation (CNH) is a rare clinical condition that is sometimes difficult to treat. We report a 51-year-old female patient who was successfully treated with intravenous fentanyl followed by transdermal fentanyl...
  6. Yilmaz A, Mahrholdt H, Athanasiadis A, Sechtem U. Non-invasive evaluation of coronary vasospasm using a combined hyperventilation and cold-pressure-test perfusion CMR protocol. J Cardiovasc Magn Reson. 2007;9:759-64 pubmed
    ..We report the case of a patient with coronary vasospasm in whom we succeeded to non-invasively provoke and subsequently non-invasively demonstrate myocardial ischemia by perfusion cardiovascular magnetic resonance (CMR)...
  7. Gelb A, Craen R, Rao G, Reddy K, Megyesi J, Mohanty B, et al. Does hyperventilation improve operating condition during supratentorial craniotomy? A multicenter randomized crossover trial. Anesth Analg. 2008;106:585-94, table of contents pubmed publisher
    b>Hyperventilation has been an integral, but poorly validated part of neuroanesthetic practice...
  8. Lehalle D, Williams C, Siu V, Clayton Smith J. Fetal pads as a clue to the diagnosis of Pitt-Hopkins syndrome. Am J Med Genet A. 2011;155A:1685-9 pubmed publisher
  9. Mizuno J, Morita S, Itou Y, Honda M, Momoeda K, Hanaoka K. [Hyperventilation syndrome before induction of and after awakening from general anesthesia]. Masui. 2009;58:768-71 pubmed
    b>Hyperventilation syndrome has often occurred as a reaction to anxiety and stress. We experienced hyperventilation syndrome before induction of and after awakening from general anesthesia...
  10. Meng L, Mantulin W, Alexander B, Cerussi A, Tromberg B, Yu Z, et al. Head-up tilt and hyperventilation produce similar changes in cerebral oxygenation and blood volume: an observational comparison study using frequency-domain near-infrared spectroscopy. Can J Anaesth. 2012;59:357-65 pubmed publisher
    ..Both head-up tilt (HUT) and hyperventilation are used to decrease brain bulk, and both may be associated with decreases in cerebral oxygenation...
  11. Taddeucci G, Bonuccelli A, Mantellassi I, Orsini A, Tarantino E. Pitt-Hopkins syndrome: report of a case with a TCF4 gene mutation. Ital J Pediatr. 2010;36:12 pubmed publisher
    ..We will discuss the clinical and genetic diagnosis of a child with severe psychomotor delay, who at 3 years of age presented with paroxysms of hyperpnea-apnea and seizures unrelated to breathing anomalies...
  12. Zavorsky G, Kim D, Christou N. Compensatory exercise hyperventilation is restored in the morbidly obese after bariatric surgery. Obes Surg. 2008;18:549-59 pubmed publisher
    Morbidly obese individuals may have poor compensatory hyperventilation during exercise...
  13. Zhuang J, Xu F, Frazier D. Hyperventilation evoked by activation of the vicinity of the caudal inferior olivary nucleus depends on the fastigial nucleus in anesthetized rats. J Appl Physiol (1985). 2008;104:1351-8 pubmed publisher
    ..These findings strongly suggest that vIOc neurons play a significant role in modulation of respiratory activity, largely depending on their projections to the FNr...
  14. Jensen D, Duffin J, Lam Y, Webb K, Simpson J, Davies G, et al. Physiological mechanisms of hyperventilation during human pregnancy. Respir Physiol Neurobiol. 2008;161:76-86 pubmed publisher
    ..non-chemoreflex) and central chemoreflex drives to breathe, acid-base balance and female sex hormones in the hyperventilation of human pregnancy. Thirty-five healthy women were studied in the third trimester (TM(3); 36.3+/-1...
  15. Shu B, Chang Y, Lee F, Tzeng D, Lin H, Lung F. Parental attachment, premorbid personality, and mental health in young males with hyperventilation syndrome. Psychiatry Res. 2007;153:163-70 pubmed
    The aim of the study was to examine the predisposing and precipitating factors in the development of hyperventilation syndrome in males during military training in Taiwan...
  16. Fujii N, Honda Y, Delliaux S, Tsuji B, Watanabe K, Sugihara A, et al. Effect of voluntary hypocapnic hyperventilation on cutaneous circulation in resting heated humans. Am J Physiol Regul Integr Comp Physiol. 2012;303:R975-83 pubmed publisher
    ..In the present study, we investigated whether hypocapnia induced by voluntary hyperventilation affects the blood flow response to heat stress in the nonglabrous skin of resting humans...
  17. Rangel Castilla L, Lara L, Gopinath S, Swank P, Valadka A, Robertson C. Cerebral hemodynamic effects of acute hyperoxia and hyperventilation after severe traumatic brain injury. J Neurotrauma. 2010;27:1853-63 pubmed publisher
    The purpose of this study was to examine the effects of hyperventilation or hyperoxia on cerebral hemodynamic parameters over time in patients with severe traumatic brain injury (TBI). We prospectively studied 186 patients with severe TBI...
  18. Hirano Y, Uehara H, Nakamura H, Ikuta S, Nakano M, Akiyama S, et al. Diagnosis of vasospastic angina: comparison of hyperventilation and cold-pressor stress echocardiography, hyperventilation and cold-pressor stress coronary angiography, and coronary angiography with intracoronary injection of acetylcholine. Int J Cardiol. 2007;116:331-7 pubmed
  19. Bluher S, Schulz M, Bierbach U, Meixensberger J, Tröbs R, Hirsch W, et al. Central lactic acidosis, hyperventilation, and respiratory alkalosis: leading clinical features in a 3-year-old boy with malignant meningeal melanoma. Eur J Pediatr. 2008;167:483-5 pubmed
    ..A 3-year-old boy was referred to our hospital with symptoms of hyperventilation, dyspnoea, tachycardia, respiratory alkalosis, inarticulate speech, and fatigue...
  20. Pittig A, Arch J, Lam C, Craske M. Heart rate and heart rate variability in panic, social anxiety, obsessive-compulsive, and generalized anxiety disorders at baseline and in response to relaxation and hyperventilation. Int J Psychophysiol. 2013;87:19-27 pubmed publisher
    ..Baseline HRV differences were maintained throughout relaxation. For hyperventilation, PD and GAD demonstrated greater HR than controls...
  21. Friedman S, Jensen J, Frederick B, Artru A, Renshaw P, Dager S. Brain changes to hypocapnia using rapidly interleaved phosphorus-proton magnetic resonance spectroscopy at 4 T. J Cereb Blood Flow Metab. 2007;27:646-53 pubmed
    ..25 U), phosphocreatine (PCr) decreases (>30%), and adenosine triphosphate (ATP) decreases (>10%) after hyperventilation (HV) (20 mm Hg PaCO(2))...
  22. Gibson D, Bruton A, Lewith G, Mullee M. Effects of acupuncture as a treatment for hyperventilation syndrome: a pilot, randomized crossover trial. J Altern Complement Med. 2007;13:39-46 pubmed
    Sustained and subtle hyperventilation can result in a wide variety of symptoms, leading to a chronic condition that has been termed hyperventilation syndrome (HVS)...
  23. Thijs R, van Dijk J. Hyperventilation in autonomic failure. Int J Clin Pract. 2007;61:695; author reply 695-6 pubmed
  24. Leen Feldner E, Reardon L, Zvolensky M. Pubertal status and emotional reactivity to a voluntary hyperventilation challenge predicting panic symptoms and somatic complaints: a laboratory-based multi-informant test. Behav Modif. 2007;31:8-31 pubmed
    ..interactive effects of pubertal status and emotional reactivity to bodily sensations elicited by a voluntary hyperventilation challenge were examined in relation to panic symptoms and self- and parent-reported somatic complaints among ..
  25. Hasi M, Soileau B, Sebold C, Hill A, Hale D, O Donnell L, et al. The role of the TCF4 gene in the phenotype of individuals with 18q segmental deletions. Hum Genet. 2011;130:777-87 pubmed publisher
  26. Pedersen L, Winther S, Backer V, Anderson S, Larsen K. Airway responses to eucapnic hyperpnea, exercise, and methacholine in elite swimmers. Med Sci Sports Exerc. 2008;40:1567-72 pubmed publisher
  27. Choi K, Kim J, Kim H, Koo J, Kim J, Kim C, et al. Hyperventilation-induced nystagmus in peripheral vestibulopathy and cerebellopontine angle tumor. Neurology. 2007;69:1050-9 pubmed
    To determine the incidence and characteristics of hyperventilation-induced nystagmus (HIN) in cerebellopontine angle (CPA) tumors and unilateral peripheral vestibulopathy (UPV), and to elucidate differential contribution of ..
  28. Chin L, Heigenhauser G, Paterson D, Kowalchuk J. Pulmonary O2 uptake and leg blood flow kinetics during moderate exercise are slowed by hyperventilation-induced hypocapnic alkalosis. J Appl Physiol (1985). 2010;108:1641-50 pubmed publisher
    The effect of hyperventilation-induced hypocapnic alkalosis (Hypo) on the adjustment of pulmonary O2 uptake (VO2p) and leg femoral conduit artery ("bulk") blood flow (LBF) during moderate-intensity exercise (Mod) was examined in ..
  29. Studer R, Danuser B, Hildebrandt H, Arial M, Gomez P. Hyperventilation complaints in music performance anxiety among classical music students. J Psychosom Res. 2011;70:557-64 pubmed publisher
    Despite the importance of respiration and hyperventilation in anxiety disorders, research on breathing disturbances associated with hyperventilation is rare in the field of music performance anxiety (MPA, also known as stage fright)...
  30. Brockschmidt A, Filippi A, Charbel Issa P, Nelles M, Urbach H, Eter N, et al. Neurologic and ocular phenotype in Pitt-Hopkins syndrome and a zebrafish model. Hum Genet. 2011;130:645-55 pubmed publisher
    ..We provide evidence for a role of TCF4/E2-2 in ocular growth control in PTHS-patients and the zebrafish model...
  31. Marangi G, Ricciardi S, Orteschi D, Tenconi R, Monica M, Scarano G, et al. Proposal of a clinical score for the molecular test for Pitt-Hopkins syndrome. Am J Med Genet A. 2012;158A:1604-11 pubmed publisher
    ..This scoring system is also proposed for a clinically based diagnosis of PTHS in absence of a proven TCF4 mutation...
  32. Burykh E. Interaction of hypocapnia, hypoxia, brain blood flow, and brain electrical activity in voluntary hyperventilation in humans. Neurosci Behav Physiol. 2008;38:647-59 pubmed publisher
    Changes in various physiological measures in voluntary hyperventilation lasting three minutes or more in humans were studied and compared...
  33. Gridina I, Bidat E, Chevallier B, Stheneur C. [Prevalence of chronic hyperventilation syndrome in children and teenagers]. Arch Pediatr. 2013;20:265-8 pubmed publisher
    The aim of this study was to investigate the prevalence of hyperventilation syndrome in the general population of children and teenagers from the Île-de-France region (France).
  34. Sakata D, Gopalakrishnan N, Orr J, White J, Westenskow D. Hypercapnic hyperventilation shortens emergence time from isoflurane anesthesia. Anesth Analg. 2007;104:587-91 pubmed
    ..emergence time after a procedure using volatile anesthesia, 78% of anesthesiologists recently surveyed used hyperventilation to rapidly clear the anesthetic from the lungs...
  35. Forster H, Haouzi P, Dempsey J. Control of breathing during exercise. Compr Physiol. 2012;2:743-77 pubmed publisher
    ..Fifth, the hyperventilation during heavy exercise is not primarily due to lactacidosis stimulation of carotid chemoreceptors...
  36. Niebauer J, White M, Zinkan J, Youngblood A, Tofil N. Hyperventilation in pediatric resuscitation: performance in simulated pediatric medical emergencies. Pediatrics. 2011;128:e1195-200 pubmed publisher
  37. Armani R, Archer H, Clarke A, Vasudevan P, Zweier C, Ho G, et al. Transcription factor 4 and myocyte enhancer factor 2C mutations are not common causes of Rett syndrome. Am J Med Genet A. 2012;158A:713-9 pubmed publisher
  38. Sepp M, Pruunsild P, Timmusk T. Pitt-Hopkins syndrome-associated mutations in TCF4 lead to variable impairment of the transcription factor function ranging from hypomorphic to dominant-negative effects. Hum Mol Genet. 2012;21:2873-88 pubmed publisher
    ..We conclude that different PTHS-associated mutations impair the functions of TCF4 by diverse mechanisms and to a varying extent, possibly contributing to the phenotypic variability of PTHS patients...
  39. Cavaliere F, Volpe C, Gargaruti R, Poscia A, Di Donato M, Grieco G, et al. Effects of acute hypoventilation and hyperventilation on exhaled carbon monoxide measurement in healthy volunteers. BMC Pulm Med. 2009;9:51 pubmed publisher
    High levels of exhaled carbon monoxide (eCO) are a marker of airway or lung inflammation. We investigated whether hypo- or hyperventilation can affect measured values.
  40. Meuret A, Ritz T. Hyperventilation in panic disorder and asthma: empirical evidence and clinical strategies. Int J Psychophysiol. 2010;78:68-79 pubmed publisher
    Sustained or spontaneous hyperventilation has been associated with a variety of physical symptoms and has been linked to a number of organic illnesses and mental disorders...
  41. Zweier C, Peippo M, Hoyer J, Sousa S, Bottani A, Clayton Smith J, et al. Haploinsufficiency of TCF4 causes syndromal mental retardation with intermittent hyperventilation (Pitt-Hopkins syndrome). Am J Hum Genet. 2007;80:994-1001 pubmed
    ..syndrome of so-far-unknown etiology characterized by mental retardation, wide mouth, and intermittent hyperventilation. By molecular karyotyping with GeneChip Human Mapping 100K SNP arrays, we detected a 1.2-Mb deletion on 18q21...
  42. Coppola G, Curra A, Sava S, Alibardi A, Parisi V, Pierelli F, et al. Changes in visual-evoked potential habituation induced by hyperventilation in migraine. J Headache Pain. 2010;11:497-503 pubmed publisher
    b>Hyperventilation is often associated with stress, an established trigger factor for migraine. Between attacks, migraine is associated with a deficit in habituation to visual-evoked potentials (VEP) that worsens just before the attack...
  43. Umeda A, Kawasaki K, Abe T, Watanabe M, Ishizaka A, Okada Y. Hyperventilation and finger exercise increase venous-arterial Pco2 and pH differences. Am J Emerg Med. 2008;26:975-80 pubmed publisher
    ..However, it has not been generally agreed that the application of VBGA is practically meaningful in routine clinical situations such as in an ED...
  44. Lu C, Lin T, Yu M, Chen T, Lin C, CHIANG J, et al. Effects of changes in alveolar ventilation on isoflurane arterial blood concentration and its uptake into the human body. Pharmacology. 2009;83:150-6 pubmed publisher
    ..e. hyperventilation, normal ventilation and hypoventilation...
  45. Sakata D, Gopalakrishnan N, Orr J, White J, Westenskow D. Rapid recovery from sevoflurane and desflurane with hypercapnia and hyperventilation. Anesth Analg. 2007;105:79-82 pubmed
    Hypercapnia with hyperventilation shortens the time between turning off the vaporizer (1 MAC) and when patients open their eyes after isoflurane anesthesia by 62%.
  46. Kanamaru M, Homma I. Dorsomedial medullary 5-HT2 receptors mediate immediate onset of initial hyperventilation, airway dilation, and ventilatory decline during hypoxia in mice. Am J Physiol Regul Integr Comp Physiol. 2009;297:R34-41 pubmed publisher
    ..The interaction may elicit cycles between hyperventilation with airway dilation and hypoventilation with airway narrowing...
  47. Wollburg E, Roth W, Kim S. Effects of breathing training on voluntary hypo- and hyperventilation in patients with panic disorder and episodic anxiety. Appl Psychophysiol Biofeedback. 2011;36:81-91 pubmed publisher
    ..patients, 39 Episodic Anxiety patients, and 20 non-anxious controls underwent voluntary hypoventilation and hyperventilation tests twice while psychophysiological measures were recorded...
  48. Ouvrier R. Hyperventilation and the Pitt-Hopkins syndrome. Dev Med Child Neurol. 2008;50:481 pubmed publisher
  49. Giurgea I, Missirian C, Cacciagli P, Whalen S, Fredriksen T, Gaillon T, et al. TCF4 deletions in Pitt-Hopkins Syndrome. Hum Mutat. 2008;29:E242-51 pubmed publisher
    Pitt-Hopkins syndrome (PHS) is a probably underdiagnosed, syndromic mental retardation disorder, marked by hyperventilation episodes and characteristic dysmorphism (large beaked nose, wide mouth, fleshy lips, and clubbed fingertips)...
  50. Holley A, Cohee B, Walter R, Shah A, King C, Roop S. Eucapnic voluntary hyperventilation is superior to methacholine challenge testing for detecting airway hyperreactivity in nonathletes. J Asthma. 2012;49:614-9 pubmed publisher
    Response to eucapnic voluntary hyperventilation (EVH) has not been compared with methacholine challenge testing (MCCT) in nonathletes being evaluated for dyspnea on exertion.
  51. Chin L, Leigh R, Heigenhauser G, Rossiter H, Paterson D, Kowalchuk J. Hyperventilation-induced hypocapnic alkalosis slows the adaptation of pulmonary O2 uptake during the transition to moderate-intensity exercise. J Physiol. 2007;583:351-64 pubmed
    The effect of voluntary hyperventilation-induced hypocapnic alkalosis (RALK) on pulmonary O2 uptake (VO2) kinetics and muscle deoxygenation was examined in young male adults (n=8) during moderate-intensity exercise...
  52. Califano L, Melillo M, Vassallo A, Mazzone S. Hyperventilation-induced nystagmus in a large series of vestibular patients. Acta Otorhinolaryngol Ital. 2011;31:17-26 pubmed
    The Hyperventilation Test is widely used in the "bed-side examination" of vestibular patients...
  53. Marangi G, Ricciardi S, Orteschi D, Lattante S, Murdolo M, Dallapiccola B, et al. The Pitt-Hopkins syndrome: report of 16 new patients and clinical diagnostic criteria. Am J Med Genet A. 2011;155A:1536-45 pubmed publisher
    ..Based on striking clinical criteria, a diagnosis of PTHS was made clinically in two patients who had normal TCF4. This report deals with the first series of PTHS patients of Italian origin...
  54. Abbiss C, Nosaka K, Laursen P. Hyperthermic-induced hyperventilation and associated respiratory alkalosis in humans. Eur J Appl Physiol. 2007;100:63-9 pubmed
    ..This study has shown that prolonged self-paced cycling is associated with a hyperthermic-induced hyperventilation, causing a decrease in arterialized carbon dioxide tension and consequential respiratory alkalosis.
  55. Marsden K, Haykowsky M, Smirl J, Jones H, Nelson M, Altamirano Diaz L, et al. Aging blunts hyperventilation-induced hypocapnia and reduction in cerebral blood flow velocity during maximal exercise. Age (Dordr). 2012;34:725-35 pubmed publisher
    ..from rest to ?60% of peak oxygen uptake (VO(2peak)) and thereafter decreases towards baseline due to hyperventilation-induced hypocapnia and subsequent cerebral vasoconstriction...
  56. Lu C, Lin T, Hsu C, Yu M, Chen T, Chen R, et al. Hyperventilation accelerates the rise of arterial blood concentrations of desflurane in gynecologic patients. Clinics (Sao Paulo). 2012;67:1029-34 pubmed
    ..We investigated whether ventilation volume affects the rate of desflurane uptake by examining arterial blood concentrations...
  57. Davis D, Douglas D, Koenig W, Carrison D, Buono C, Dunford J. Hyperventilation following aero-medical rapid sequence intubation may be a deliberate response to hypoxemia. Resuscitation. 2007;73:354-61 pubmed
    Recent studies document a high incidence of hyperventilation by prehospital providers, with a potentially detrimental effect on outcome in traumatic brain injury (TBI).
  58. Freire R, Lopes F, Valenca A, Nascimento I, Veras A, Mezzasalma M, et al. Panic disorder respiratory subtype: a comparison between responses to hyperventilation and CO2 challenge tests. Psychiatry Res. 2008;157:307-10 pubmed
    ..The respiratory subtype patients were observed to be more sensitive to the 35% CO(2) inhalation challenge test and the hyperventilation test than the non-respiratory subtype patients.
  59. Ikarashi F, Tsuchiya A. Middle ear gas exchange via the mucosa: estimation by hyperventilation. Acta Otolaryngol. 2008;128:9-12 pubmed
    ..It was verified that gas exchange via the mucosa is less likely to be impaired than gas exchange via the eustachian tube...
  60. Coles J, Fryer T, Coleman M, Smielewski P, Gupta A, Minhas P, et al. Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism. Crit Care Med. 2007;35:568-78 pubmed
    To determine whether hyperventilation exacerbates cerebral ischemia and compromises oxygen metabolism (CMRO2) following closed head injury.
  61. Steinbusch C, van Roozendaal K, Tserpelis D, Smeets E, Kranenburg de Koning T, de Waal K, et al. Somatic mosaicism in a mother of two children with Pitt-Hopkins syndrome. Clin Genet. 2013;83:73-7 pubmed publisher
    ..We suggest careful studies in parents of other patients with PTHS to determine the frequency of germline and somatic mosaicism for TCF4 mutations...
  62. Sparing R, Dafotakis M, Buelte D, Meister I, Noth J. Excitability of human motor and visual cortex before, during, and after hyperventilation. J Appl Physiol (1985). 2007;102:406-11 pubmed
    In humans, hyperventilation (HV) has various effects on systemic physiology and, in particular, on neuronal excitability and synaptic transmission. However, it is far from clear how the effects of HV are mediated at the cortical level...
  63. Gregor A, Albrecht B, Bader I, Bijlsma E, Ekici A, Engels H, et al. Expanding the clinical spectrum associated with defects in CNTNAP2 and NRXN1. BMC Med Genet. 2011;12:106 pubmed publisher
    ..Recently, homozygous or compound heterozygous defects in either gene were reported as causative for severe intellectual disability...
  64. Garcia G. [Hyperventilation syndrome]. Rev Prat. 2011;61:456-9 pubmed
    b>Hyperventilation syndrome is a disorder affecting children and adults, mostly women. It is frequently associated with anxiety disorders, and greatly affects quality of life...
  65. Duff J, Joffe A, Sevcik W, Decaen A. Autoresuscitation after pediatric cardiac arrest: is hyperventilation a cause?. Pediatr Emerg Care. 2011;27:208-9 pubmed publisher
    ..There are no published reports of this phenomenon in children. We report 2 pediatric cases of the Lazarus phenomenon, likely caused by unintentional hyperventilation during resuscitation.