altitude sickness

Summary

Summary: Multiple symptoms associated with reduced oxygen at high ALTITUDE.

Top Publications

  1. Bosch M, Barthelmes D, Merz T, Truffer F, Knecht P, Petrig B, et al. Intraocular pressure during a very high altitude climb. Invest Ophthalmol Vis Sci. 2010;51:1609-13 pubmed publisher
    ..Reports on intraocular pressure (IOP) changes at high altitudes have provided inconsistent and even conflicting..
  2. Macinnis M, Wang P, Koehle M, Rupert J. The genetics of altitude tolerance: the evidence for inherited susceptibility to acute mountain sickness. J Occup Environ Med. 2011;53:159-68 pubmed publisher
    ..Whether there is a genetic contribution to AMS susceptibility is a central question in high-altitude medicine. This article provides a systematic review of the evidence supporting such an innate predisposition...
  3. Luks A, McIntosh S, Grissom C, Auerbach P, Rodway G, Schoene R, et al. Wilderness Medical Society consensus guidelines for the prevention and treatment of acute altitude illness. Wilderness Environ Med. 2010;21:146-55 pubmed publisher
    ..The guidelines also provide suggested approaches to the prevention and management of each disorder that incorporate these recommendations...
  4. Grocott M, Martin D, Wilson M, Mitchell K, Dhillon S, Mythen M, et al. Caudwell xtreme Everest expedition. High Alt Med Biol. 2010;11:133-7 pubmed publisher
    ..Unique arterial blood gas values were obtained from 4 subjects at 8400 m during descent from the summit of Everest. Arterial blood gas and microcirculatory blood flow data are discussed in detail...
  5. Subudhi A, Dimmen A, Julian C, Wilson M, Panerai R, Roach R. Effects of acetazolamide and dexamethasone on cerebral hemodynamics in hypoxia. J Appl Physiol (1985). 2011;110:1219-25 pubmed publisher
    ..Dexamethasone had no measureable cerebral hemodynamic effects in hypoxia. In conclusion, global cerebral hemodynamic changes resulting from hypoxia may not explain the development of AMS...
  6. Pasha M, Newman J. High-altitude disorders: pulmonary hypertension: pulmonary vascular disease: the global perspective. Chest. 2010;137:13S-19S pubmed publisher
    ..Genetic understanding of these disorders is in its infancy...
  7. Mairer K, Wille M, Burtscher M. The prevalence of and risk factors for acute mountain sickness in the Eastern and Western Alps. High Alt Med Biol. 2010;11:343-8 pubmed publisher
    ..Thus, expert advice by mountain guides or experienced colleagues could help to reduce the AMS risk in these subjects...
  8. Luo Y, Zou Y, Gao Y. Gene polymorphisms and high-altitude pulmonary edema susceptibility: a 2011 update. Respiration. 2012;84:155-62 pubmed publisher
    ..The goal of this review article is to summarize the current literature and to define the outstanding areas of research that need to be explored to advance our ability to predict when HAPE will occur...
  9. Beall C, Laskowski D, Erzurum S. Nitric oxide in adaptation to altitude. Free Radic Biol Med. 2012;52:1123-34 pubmed publisher
    ..Gains in understanding will require integrating appropriate methods and measurement techniques with indicators of adaptive function under hypoxic stress...

More Information

Publications62

  1. Mishra A, Ali Z, Vibhuti A, Kumar R, Alam P, Ram R, et al. CYBA and GSTP1 variants associate with oxidative stress under hypobaric hypoxia as observed in high-altitude pulmonary oedema. Clin Sci (Lond). 2012;122:299-309 pubmed publisher
    ..In conclusion, the risk alleles of CYBA and GSTP1, their haplotypes and gene-gene interactions are associated with imbalanced oxidative stress and, thereby, with high-altitude adaptation and mal-adaptation...
  2. Julian C, Subudhi A, Wilson M, Dimmen A, Pecha T, Roach R. Acute mountain sickness, inflammation, and permeability: new insights from a blood biomarker study. J Appl Physiol (1985). 2011;111:392-9 pubmed publisher
    ..Conversely, AMS susceptibility does not appear to be related to an exaggerated inflammatory response...
  3. Wilson M, Levett D, Dhillon S, Mitchell K, Morgan J, Grocott M, et al. Stroke at high altitude diagnosed in the field using portable ultrasound. Wilderness Environ Med. 2011;22:54-7 pubmed publisher
    ..The patient was then evacuated to a hospital in Kathmandu over the next 48 hours. This case report suggests that portable ultrasound could be used in the prehospital arena to enable early diagnosis of thrombotic stroke...
  4. Wang B, Zhang Y, Zhang F, Lin H, Wang X, Wan N, et al. On the origin of Tibetans and their genetic basis in adapting high-altitude environments. PLoS ONE. 2011;6:e17002 pubmed publisher
    ..Most of these genes were highly correlated with population-specific and beneficial phenotypes, such as high infant survival rate and the absence of chronic mountain sickness...
  5. Modesti P, Rapi S, Paniccia R, Bilo G, Revera M, Agostoni P, et al. Index measured at an intermediate altitude to predict impending acute mountain sickness. Med Sci Sports Exerc. 2011;43:1811-8 pubmed publisher
    ..The aim of the present study was to develop a predictive index, measured at an intermediate altitude, to predict the onset of AMS at a higher altitude...
  6. Ho T, Kao W, Lee S, Lin P, Chen J, Liu J. High-altitude retinopathy after climbing Mount Aconcagua in a group of experienced climbers. Retina. 2011;31:1650-5 pubmed publisher
    ..Visual disturbances after high-altitude exposure were first reported in 1969. Manifestations may include retinal hemorrhage, papilledema, and vitreous hemorrhage...
  7. Beall C, Cavalleri G, Deng L, Elston R, Gao Y, Knight J, et al. Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci U S A. 2010;107:11459-64 pubmed publisher
    ..Whichever of these explanations is correct, the evidence for genetic selection at the EPAS1 locus from the GWADS study is supported by the replicated studies associating function with the allelic variants...
  8. Fulco C, Muza S, Beidleman B, Demes R, Staab J, Jones J, et al. Effect of repeated normobaric hypoxia exposures during sleep on acute mountain sickness, exercise performance, and sleep during exposure to terrestrial altitude. Am J Physiol Regul Integr Comp Physiol. 2011;300:R428-36 pubmed publisher
    ..Under HH conditions, the higher sleep Sa(O(2)) may have contributed to a lessening of AMS upon awakening but had no impact on AMS or exercise performance for the remainder of each day...
  9. Maggiorini M. Prevention and treatment of high-altitude pulmonary edema. Prog Cardiovasc Dis. 2010;52:500-6 pubmed publisher
    ..If progressive high altitude acclimatization would not be possible, prophylaxis with nifedipine or tadalafil for long sojourns at high altitude or dexamethasone for a short stay of less then 5 days should be recommended...
  10. Scherrer U, Rexhaj E, Jayet P, Allemann Y, Sartori C. New insights in the pathogenesis of high-altitude pulmonary edema. Prog Cardiovasc Dis. 2010;52:485-92 pubmed publisher
  11. Wang S, Chen Y, Kao W, Lin Y, Chen J, Chiu T, et al. Epidemiology of acute mountain sickness on Jade Mountain, Taiwan: an annual prospective observational study. High Alt Med Biol. 2010;11:43-9 pubmed publisher
    ..The overall presentation of AMS was similar to that on other major world mountains...
  12. Arora R, Jha K, Sathian B. Retinal changes in various altitude illnesses. Singapore Med J. 2011;52:685-8 pubmed
    ..This study aimed to evaluate the retinal changes associated with altitude illness in young soldiers...
  13. Siques P, Brito J, Banegas J, Leon Velarde F, de la Cruz Troca J, Lopez V, et al. Blood pressure responses in young adults first exposed to high altitude for 12 months at 3550 m. High Alt Med Biol. 2009;10:329-35 pubmed publisher
    ..Further, a sustained high DBP should be a matter of epidemiological concern and emphasizes the need for BP monitoring among young lowlanders exposed to high altitude...
  14. Dehnert C, Luks A, Schendler G, Menold E, Berger M, Mairbaurl H, et al. No evidence for interstitial lung oedema by extensive pulmonary function testing at 4,559 m. Eur Respir J. 2010;35:812-20 pubmed publisher
    ..Data obtained in mountaineers with early mild HAPE suggest that these methods may not be sensitive enough for the detection of interstitial pulmonary fluid accumulation...
  15. You H, Li X, Pei T, Huang Q, Liu F, Gao Y. Predictive value of basal exhaled nitric oxide and carbon monoxide for acute mountain sickness. Wilderness Environ Med. 2012;23:316-24 pubmed publisher
  16. Alkorta Aranburu G, Beall C, Witonsky D, Gebremedhin A, Pritchard J, Di Rienzo A. The genetic architecture of adaptations to high altitude in Ethiopia. PLoS Genet. 2012;8:e1003110 pubmed publisher
    ..Finally, a comparison of CpG methylation levels between high- and lowlanders found several significant signals at individual genes in the Oromo...
  17. Burtscher M, Mairer K, Wille M, Gatterer H, Ruedl G, Faulhaber M, et al. Short-term exposure to hypoxia for work and leisure activities in health and disease: which level of hypoxia is safe?. Sleep Breath. 2012;16:435-42 pubmed publisher
    ..g., with fire control systems, there is no clear consensus on the level of hypoxia which is generally well tolerated by human beings when acutely exposed for short durations (hours to several days)...
  18. Li X, Tao F, Pei T, You H, Liu Y, Gao Y. Population level determinants of acute mountain sickness among young men: a retrospective study. BMC Public Health. 2011;11:740 pubmed publisher
    ..The aim of this study was to evaluate the population level risk factors and build a multivariate model, which might be applicable to reduce the effects of AMS on Chinese young men traveling to this region...
  19. Seupaul R, Welch J, Malka S, Emmett T. Pharmacologic prophylaxis for acute mountain sickness: a systematic shortcut review. Ann Emerg Med. 2012;59:307-317.e1 pubmed publisher
    ..Since 2000, a number of other agents have been reported to be beneficial. This EBEM review evaluates the most current evidence on this topic...
  20. Burtscher M, Mairer K, Wille M, Broessner G. Risk factors for high-altitude headache in mountaineers. Cephalalgia. 2011;31:706-11 pubmed publisher
    ..The aim was to identify most relevant risk factors of high-altitude headache within a broad mountaineering population through a prospective, observational, rater-blinded study...
  21. Shen G, Xie K, Yan Y, Jing D, Tang C, Wu X, et al. The role of oxygen-increased respirator in humans ascending to high altitude. Biomed Eng Online. 2012;11:49 pubmed publisher
    ..Many instruments have been developed to treat mild cases of AMS. However, long-lasting and portable anti-hypoxia equipment for individual is not yet available...
  22. Ge R, Wood H, Yang H, Liu Y, Wang X, BABB T. The body weight loss during acute exposure to high-altitude hypoxia in sea level residents. Sheng Li Xue Bao. 2010;62:541-6 pubmed
  23. Tannheimer M, Fusch C, Böning D, Thomas A, Engelhardt M, Schmidt R. Changes of hematocrit and hemoglobin concentration in the cold Himalayan environment in dependence on total body fluid. Sleep Breath. 2010;14:193-9 pubmed publisher
    ..Therefore, the influence of water distribution on hemoglobin (Hb) and hematocrit (Hct) values during a long-term exposure at high altitude was investigated...
  24. Schommer K, Wiesegart N, Menold E, Haas U, Lahr K, Buhl H, et al. Training in normobaric hypoxia and its effects on acute mountain sickness after rapid ascent to 4559 m. High Alt Med Biol. 2010;11:19-25 pubmed publisher
    ..Whether such a program would prevent AMS at higher altitudes, but with slower ascent, remains to be tested...
  25. Palmer B. Physiology and pathophysiology with ascent to altitude. Am J Med Sci. 2010;340:69-77 pubmed publisher
    ..The most common clinical manifestations of altitude illness are acute mountain sickness, high altitude pulmonary edema, and high altitude cerebral edema...
  26. Xu S, Li S, Yang Y, Tan J, Lou H, Jin W, et al. A genome-wide search for signals of high-altitude adaptation in Tibetans. Mol Biol Evol. 2011;28:1003-11 pubmed publisher
    ..Our results also suggest limitations of extended haplotype homozygosity-based method due to its compromised power in case the natural selection initiated long time ago and particularly in genomic regions with recombination hotspots...
  27. Willmann G, Fischer M, Schatz A, Schommer K, Messias A, Zrenner E, et al. Quantification of optic disc edema during exposure to high altitude shows no correlation to acute mountain sickness. PLoS ONE. 2011;6:e27022 pubmed publisher
    ..This work is related to the Tuebingen High Altitude Ophthalmology (THAO) study...
  28. She J, Goolaerts A, Shen J, Bi J, Tong L, Gao L, et al. KGF-2 targets alveolar epithelia and capillary endothelia to reduce high altitude pulmonary oedema in rats. J Cell Mol Med. 2012;16:3074-84 pubmed publisher
    ..Thus, KGF-2 may represent a potential drug candidate for the prevention of HAPE...
  29. Huang H, Tseng C, Fan J, Yen D, Kao W, Chang S, et al. Alternations of heart rate variability at lower altitude in the predication of trekkers with acute mountain sickness at high altitude. Clin J Sport Med. 2010;20:58-63 pubmed publisher
    ..To determine the change and relationship of spectral components of heart rate variability (HRV) measurements in subjects with or without acute mountain sickness (AMS) at both low and high altitude...
  30. Naeije R. Physiological adaptation of the cardiovascular system to high altitude. Prog Cardiovasc Dis. 2010;52:456-66 pubmed publisher
    ..Altitude exposure carries no identified risk of myocardial ischemia in healthy subjects but has to be considered as a potential stress in patients with previous cardiovascular conditions...
  31. Gertsch J, Lipman G, Holck P, Merritt A, Mulcahy A, Fisher R, et al. Prospective, double-blind, randomized, placebo-controlled comparison of acetazolamide versus ibuprofen for prophylaxis against high altitude headache: the Headache Evaluation at Altitude Trial (HEAT). Wilderness Environ Med. 2010;21:236-43 pubmed publisher
    ..Toward this end, we initiated a prospective, double-blind, randomized, placebo-controlled trial in the Nepal Himalaya designed to compare the effectiveness of ibuprofen and acetazolamide for the prevention of HAH...
  32. Aggarwal S, Negi S, Jha P, Singh P, Stobdan T, Pasha M, et al. EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda. Proc Natl Acad Sci U S A. 2010;107:18961-6 pubmed publisher
  33. Seth R, Adelman R. High-altitude retinopathy and optical coherence tomography findings. Semin Ophthalmol. 2010;25:13-5 pubmed publisher
    ..To report the case and OCT findings of a case of high altitude retinopathy (HAR)...
  34. Wu T, Ding S, Liu J, Jia J, Chai Z, Dai R, et al. Smoking, acute mountain sickness and altitude acclimatisation: a cohort study. Thorax. 2012;67:914-9 pubmed publisher
    ..The relationship between cigarette smoking and acute mountain sickness (AMS) is not clear...
  35. Gertsch J, Corbett B, Holck P, Mulcahy A, Watts M, Stillwagon N, et al. Altitude Sickness in Climbers and Efficacy of NSAIDs Trial (ASCENT): randomized, controlled trial of ibuprofen versus placebo for prevention of altitude illness. Wilderness Environ Med. 2012;23:307-15 pubmed publisher
    ..To study the effectiveness of ibuprofen versus placebo in preventing acute mountain sickness (AMS) and high altitude headache (HAH)...
  36. Subudhi A, Panerai R, Roach R. Effects of hypobaric hypoxia on cerebral autoregulation. Stroke. 2010;41:641-6 pubmed publisher
    ..This investigation evaluated relationship between CA and AMS over 9 hours of hypobaric hypoxia...
  37. Wu T, Ding S, Liu J, Jia J, Chai Z, Dai R. Who are more at risk for acute mountain sickness: a prospective study in Qinghai-Tibet railroad construction workers on Mt. Tanggula. Chin Med J (Engl). 2012;125:1393-400 pubmed
    ..Tanggula during the construction of the Qinghai-Tibet railroad. This study explored the risk factors predisposing workers to developing AMS and attempted to develop more effective ways of preventing and treating AMS...
  38. Peng Y, Yang Z, Zhang H, Cui C, Qi X, Luo X, et al. Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas. Mol Biol Evol. 2011;28:1075-81 pubmed publisher
  39. Castellani J, Muza S, Cheuvront S, Sils I, Fulco C, Kenefick R, et al. Effect of hypohydration and altitude exposure on aerobic exercise performance and acute mountain sickness. J Appl Physiol (1985). 2010;109:1792-800 pubmed publisher
    ..07). In conclusion, hypohydration at 3,048 m 1) degrades aerobic performance in an additive manner with that induced by ALT; and 2) did not appear to increase the prevalence/severity of AMS symptoms...
  40. Karinen H, Peltonen J, Kahonen M, Tikkanen H. Prediction of acute mountain sickness by monitoring arterial oxygen saturation during ascent. High Alt Med Biol. 2010;11:325-32 pubmed publisher
    ..The results suggest that daily evaluation of Spo? during ascent both at rest and during exercise can help to identify a population that does well at altitude...
  41. Kayser B, Dumont L, Lysakowski C, Combescure C, Haller G, Tramer M. Reappraisal of acetazolamide for the prevention of acute mountain sickness: a systematic review and meta-analysis. High Alt Med Biol. 2012;13:82-92 pubmed publisher
    ..The degree of efficacy of acetazolamide for the prevention of AMS is limited when the baseline risk is low, and there is some evidence of dose-responsiveness...
  42. Bosch M, Barthelmes D, Merz T, Knecht P, Truffer F, Bloch K, et al. New insights into changes in corneal thickness in healthy mountaineers during a very-high-altitude climb to Mount Muztagh Ata. Arch Ophthalmol. 2010;128:184-9 pubmed publisher
    ..To investigate the effect of very high altitude and different ascent profiles on central corneal thickness (CCT)...
  43. Nussbaumer Ochsner Y, Schuepfer N, Siebenmann C, Maggiorini M, Bloch K. High altitude sleep disturbances monitored by actigraphy and polysomnography. High Alt Med Biol. 2011;12:229-36 pubmed publisher
    ..Data on sleep at altitude are scant due to the limited availability of polysomnography. Therefore, we investigated whether actigraphy might serve as a simple tool for monitoring sleep during altitude field studies...
  44. Ma H, Fan P, Jing L, Yao J, He X, Yang Y, et al. Anti-hypoxic activity at simulated high altitude was isolated in petroleum ether extract of Saussurea involucrata. J Ethnopharmacol. 2011;137:1510-5 pubmed publisher
    ..Rhodiola algida, Saussurea involucrata, and other herbs grown in Qinghai-Tibetan plateau have long been used to prevent and treat acute mountain sickness...
  45. Leon Velarde F, Villafuerte F, Richalet J. Chronic mountain sickness and the heart. Prog Cardiovasc Dis. 2010;52:540-9 pubmed publisher
  46. Bloch K, Latshang T, Turk A, Hess T, Hefti U, Merz T, et al. Nocturnal periodic breathing during acclimatization at very high altitude at Mount Muztagh Ata (7,546 m). Am J Respir Crit Care Med. 2010;182:562-8 pubmed publisher
    ..Quantitative data on ventilation during acclimatization at very high altitude are scant. Therefore, we monitored nocturnal ventilation and oxygen saturation in mountaineers ascending Mt. Muztagh Ata (7,546 m)...
  47. Basnyat B, Holck P, Pun M, Halverson S, Szawarski P, Gertsch J, et al. Spironolactone does not prevent acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial by SPACE Trial Group (spironolactone and acetazolamide trial in the prevention of acute mountain sickness group). Wilderness Environ Med. 2011;22:15-22 pubmed publisher
    ..Hence, a prospective, double-blind, randomized, placebo-controlled trial was conducted to evaluate the efficacy of spironolactone in the prevention of AMS...
  48. Koehle M, Guenette J, Warburton D. Oximetry, heart rate variability, and the diagnosis of mild-to-moderate acute mountain sickness. Eur J Emerg Med. 2010;17:119-22 pubmed publisher
    ..In conclusion, in patients with SpO2 of 86% or more at 4380?m or higher, the likelihood of AMS is low. Diastolic blood pressure correlated with AMS severity, whereas heart rate variability was not useful in the diagnosis of AMS...
  49. Kallenberg K, Bailey D, Christ S, Mohr A, Roukens R, Menold E, et al. Magnetic resonance imaging evidence of cytotoxic cerebral edema in acute mountain sickness. J Cereb Blood Flow Metab. 2007;27:1064-71 pubmed
    ..5% of total brain volume...
  50. Pesce C, Leal C, Pinto H, Gonzalez G, Maggiorini M, Schneider M, et al. Determinants of acute mountain sickness and success on Mount Aconcagua (6962 m). High Alt Med Biol. 2005;6:158-66 pubmed
    ..Those who are often in the mountains and who have already climbed to altitudes above 6000 m and are not susceptible for AMS have the best options for summiting Aconcagua...
  51. Bailey D. Ascorbate, blood-brain barrier function and acute mountain sickness: a radical hypothesis. Wilderness Environ Med. 2004;15:231-3 pubmed
  52. Hotta J, Hanaoka M, Droma Y, Katsuyama Y, Ota M, Kobayashi T. Polymorphisms of renin-angiotensin system genes with high-altitude pulmonary edema in Japanese subjects. Chest. 2004;126:825-30 pubmed
    ..Investigating the associations of the polymorphisms in the genes of RAS with HAPE is to elucidate the genetic background underlying this disease...
  53. Anand I, Wu T. Syndromes of subacute mountain sickness. High Alt Med Biol. 2004;5:156-70 pubmed
    ..Thus, it appears that both these syndromes are human counterparts of brisket disease in cattle...