pleural effusion

Summary

Summary: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.

Top Publications

  1. Basu S, Bhadani S, Shukla V. A dangerous pleural effusion. Ann R Coll Surg Engl. 2010;92:W53-4 pubmed publisher
    ..A chest X-ray and a diagnostic pleural tap can confirm the diagnosis. Once detected, an aggressive management should be instituted to prevent organ failure and death...
  2. Kim D, Goh H, Kim S, Cho B, Kim D. Long-term pattern of pleural effusion from chronic myeloid leukemia patients in second-line dasatinib therapy. Int J Hematol. 2011;94:361-371 pubmed publisher
    ..However, some patients treated with dasatinib experience pleural effusions (PEs). The determinants of pleural effusion in long-term dasatinib treatment (median 35 months, range 1-55) were investigated in single-center data of ..
  3. Lin T, Hwang K, Liu C, Tang R, Lin C, Gilbert G, et al. Etiology of empyema thoracis and parapneumonic pleural effusion in Taiwanese children and adolescents younger than 18 years of age. Pediatr Infect Dis J. 2013;32:419-21 pubmed publisher
    We analyzed blood and pleural fluid samples from 89 Taiwanese children with empyema thoracis and parapneumonic pleural effusion. Streptococcus pneumoniae was the major pathogen, identified in 12 children by bacterial culture and 53 ..
  4. Sharma S, Solanki R, Mohan A, Jain N, Chauhan L. Outcomes of Category III DOTS treatment in immunocompetent patients with tuberculosis pleural effusion. Int J Tuberc Lung Dis. 2012;16:1505-9 pubmed publisher
    ..RMP], isoniazid [INH] and pyrazinamide for 2 months, followed by RMP and INH for 4 months) under India's Revised National Tuberculosis Control Programme in patients with uncomplicated small unilateral pleural effusion (<1500 ml).
  5. Sánchez Otero N, Blanco Prieto S, Paez de la Cadena M, Vazquez Iglesias L, Fernandez Villar A, Botana Rial M, et al. Calprotectin: a novel biomarker for the diagnosis of pleural effusion. Br J Cancer. 2012;107:1876-82 pubmed publisher
    Novel non-invasive biomarkers for the precise diagnosis of malignancy in pleural effusion (PE) are needed...
  6. Ghosh I, Dey S, Das A, Bhattacharjee D, Gangopadhyay S. Cell block cytology in pleural effusion. J Indian Med Assoc. 2012;110:390-2, 396 pubmed
    ..In this study among a total of 60 cases of suspected malignant pleural effusion, 56 were confirmed to be of malignant aetiology by all modalities...
  7. Sellares J, López Giraldo A, Lucena C, Cillóniz C, Amaro R, Polverino E, et al. Influence of previous use of inhaled corticoids on the development of pleural effusion in community-acquired pneumonia. Am J Respir Crit Care Med. 2013;187:1241-8 pubmed publisher
    ..However, ICS have been associated with fewer pneumonia complications and decreased risk of pneumonia-related mortality...
  8. Chiumello D, Marino A, Cressoni M, Mietto C, Berto V, Gallazzi E, et al. Pleural effusion in patients with acute lung injury: a CT scan study. Crit Care Med. 2013;41:935-44 pubmed publisher
    b>Pleural effusion is a frequent finding in patients with acute respiratory distress syndrome...
  9. Ferro P, Canessa P, Battolla E, Dessanti P, Franceschini M, Chiaffi L, et al. Mesothelin is more useful in pleural effusion than in serum in the diagnosis of pleural mesothelioma. Anticancer Res. 2013;33:2707-13 pubmed
    Soluble mesothelin-related peptide (SMRP) is regarded as a biomarker of malignant pleural mesothelioma (MPM). Herein, we compared the diagnostic performances of SMRP in matched pleural effusion (PE-SMRP) and serum (S-SMRP).

More Information

Publications91

  1. Li X, Zhou Q, Yang W, Xiong X, Du R, Zhang J. Pleural mesothelial cells promote expansion of IL-17-producing CD8+ T cells in tuberculous pleural effusion. J Clin Immunol. 2013;33:775-87 pubmed publisher
    ..However, the possible implication of Tc17 cells in tuberculous pleural effusion remains unclarified...
  2. Xiao Y, Yong X, Fan Y, Lü M, Yang S, Hu C. microRNA detection in feces, sputum, pleural effusion and urine: novel tools for cancer screening (Review). Oncol Rep. 2013;30:535-44 pubmed publisher
    ..In the present review, we focused mainly on the application of detecting miRNAs in stool, sputum, pleural effusion and urine, to detect colon, lung and urological cancers, highlighting the role of miRNAs in early diagnosis ..
  3. Kruger D. Evaluating the adult with new-onset pleural effusion. JAAPA. 2013;26:20-7 pubmed
    PAs play an essential role in recognizing new-onset pleural effusion in adults. This article reviews risk factors, patient assessment, diagnostic testing, initial management, and treatment.
  4. Wu Y, Ye Z, Qin S, Wu C, Chen Y, Shi H. Combined detections of interleukin 27, interferon-?, and adenosine deaminase in pleural effusion for diagnosis of tuberculous pleurisy. Chin Med J (Engl). 2013;126:3215-21 pubmed
    ..interferon-? (IFN-?), or adenosine deaminase (ADA) alone plays a helpful role in diagnosing tuberculous pleural effusion (TPE)...
  5. Yang W, Liang Q, Ye Z, Niu C, Ma W, Xiong X, et al. Cell origins and diagnostic accuracy of interleukin 27 in pleural effusions. PLoS ONE. 2012;7:e40450 pubmed publisher
    ..The concentrations of IL-27 were determined in pleural fluids and sera from 68 patients with tuberculous pleural effusion, 63 malignant pleural effusion, 22 infectious pleural effusion, and 21 transudative pleural effusion...
  6. Creaney J, Dick I, Segal A, Musk A, Robinson B. Pleural effusion hyaluronic acid as a prognostic marker in pleural malignant mesothelioma. Lung Cancer. 2013;82:491-8 pubmed publisher
    ..Tumour biomarkers are being intensely investigated in MM as aids to diagnosis and prognosis. Hyaluronic acid (HA) is produced in MM but its role in prognostication remains uncertain...
  7. Lee S, Tsai C, Lee B. Chryseobacterium meningosepticum sepsis complicated with retroperitoneal hematoma and pleural effusion in a diabetic patient. J Chin Med Assoc. 2008;71:473-6 pubmed publisher
    Intra-abdominal infection due to Chryseobacterium meningosepticum is rare, and bacteremia complicated with pleural effusion and retroperitoneal hematoma caused by C. meningosepticum has not been reported previously...
  8. Seyhan E, Altin S, Cetinkaya E, Sokucu S, Gunluoglu M, Demir A, et al. The importance of pleural fluid and serum NT-proBNP levels in differentiating pleural effusion due to heart failure from other causes of effusion. Intern Med. 2009;48:287-93 pubmed
    b>Pleural effusion due to congestive heart failure (CHF) typically are transudates. Light's criteria may be insufficient in determining if the pleural effusion is transudative or exudative in patients with CHF...
  9. Goligher E, Leis J, Fowler R, Pinto R, Adhikari N, Ferguson N. Utility and safety of draining pleural effusions in mechanically ventilated patients: a systematic review and meta-analysis. Crit Care. 2011;15:R46 pubmed publisher
    ..We found no data to either support or refute claims of beneficial effects on clinically important outcomes such as duration of ventilation or length of stay. ..
  10. Wu G, Zhang S, Fang C, Liu S, Wang E. Immunocytochemical panel for distinguishing carcinoma cells from reactive mesothelial cells in pleural effusions. Cytopathology. 2008;19:212-7 pubmed publisher
    ..The aim of this study was to evaluate the individual and combined diagnostic utility of carcinoembryonic antigen (CEA), cytokeratin 19 fragments (CK19) and HBME-1 in pleural effusions of patients with lung cancer...
  11. Dikensoy O, Celik N, Kul S, Gogebakan B, Bayram H, Light R. Ischemia modified albumin in the differential diagnosis of pleural effusions. Respir Med. 2011;105:1712-7 pubmed publisher
    The differential diagnosis of pleural effusion often requires invasive procedures. Up to 25 percent of pleural effusions can remain undiagnosed with an unclear pathogenesis...
  12. Ruano R, Ramalho A, Cardoso A, Moise K, Zugaib M. Prenatal diagnosis and natural history of fetuses presenting with pleural effusion. Prenat Diagn. 2011;31:496-9 pubmed publisher
    To describe the natural history of fetuses presenting with pleural effusion. Between January 2005 and December 2009 all fetuses diagnosed with pleural effusion were followed up...
  13. Ye Z, Yuan M, Zhou Q, Du R, Yang W, Xiong X, et al. Differentiation and recruitment of Th9 cells stimulated by pleural mesothelial cells in human Mycobacterium tuberculosis infection. PLoS ONE. 2012;7:e31710 pubmed publisher
    ..showed that increased Th9 cells with the phenotype of effector memory cells were found to be in tuberculous pleural effusion as compared with blood...
  14. Long A, O Neal H, Peng S, Lane K, Light R. Comparison of pleural fluid N-terminal pro-brain natriuretic peptide and brain natriuretic-32 peptide levels. Chest. 2010;137:1369-74 pubmed publisher
    ..Furthermore, when compared with BNP, NT-proBNP is a more accurate diagnostic aid in the evaluation of pleural effusions of cardiac origin. ..
  15. Ribeiro S, Vargas F, Antonangelo L, Marchi E, Genofre E, Acencio M, et al. Monoclonal anti-vascular endothelial growth factor antibody reduces fluid volume in an experimental model of inflammatory pleural effusion. Respirology. 2009;14:1188-93 pubmed publisher
    ..The results also suggest that bevacizumab should probably be avoided in patients requiring pleurodesis. ..
  16. Liao H, Na M, Dikensoy O, Lane K, Randal B, Light R. Diagnostic value of pleural fluid N-terminal pro-brain natriuretic peptide levels in patients with cardiovascular diseases. Respirology. 2008;13:53-7 pubmed publisher
    ..Measurement of the NT-proBNP level in pleural fluid is accurate in diagnosing the etiology of the effusion as CHF. Pleural fluid levels above 2220 pg/mL are essentially diagnostic that the pleural effusion is due to CHF.
  17. Yun T, Im Y, Jung S, Jhang W, Park J, Seo D, et al. Pulmonary vascular compliance and pleural effusion duration after the Fontan procedure. Int J Cardiol. 2009;133:55-61 pubmed publisher
    ..We hypothesized that low pulmonary vascular compliance (PVC) is a risk factor for persistent pleural effusion after the Fontan operation...
  18. Sahn S. Getting the most from pleural fluid analysis. Respirology. 2012;17:270-7 pubmed publisher
    Virtually, every pulmonary disease and most non-pulmonary diseases may be associated with a pleural effusion. The presence of a pleural effusion allows the clinician to 'diagnose' or narrow the differential diagnosis and aetiology of the ..
  19. Determann R, Achouiti A, El Solh A, Bresser P, Vijfhuizen J, Spronk P, et al. Infectious pleural effusions can be identified by sTREM-1 levels. Respir Med. 2010;104:310-5 pubmed publisher
    ..5microg/ml C-reactive protein, and 60% and 64% respectively for a cut-off value of 0.15 ng/ml procalcitonin. sTREM-1 is superior to C-reactive protein and procalcitonin in detecting infection. ..
  20. Lin M, Wang J, Yu C, Lee L, Yang P. Mycobacterium tuberculosis and polymorphonuclear pleural effusion: incidence and clinical pointers. Respir Med. 2009;103:820-6 pubmed publisher
    Delayed diagnosis and treatment of a polymorphonuclear cell (PMN)-predominant pleural effusion due to Mycobacterium tuberculosis (MTB) are associated with poor outcome and the risk of tuberculosis transmission...
  21. McGrath E, Warriner D, Anderson P. Pleural fluid characteristics of tuberculous pleural effusions. Heart Lung. 2010;39:540-3 pubmed publisher
    Mycobacterium tuberculosis (TB) infection of the pleural space is an important cause of pleural effusion in areas of high TB prevalence. Microbiological analyses of pleural fluid in the acute setting may be negative...
  22. Kamiya H, Ishikawa R, Moriya A, Arai A, Morimoto K, Ando T, et al. Disseminated cryptococcosis complicated with bilateral pleural effusion and ascites during corticosteroid therapy for organizing pneumonia with myelodysplastic syndrome. Intern Med. 2008;47:1981-6 pubmed
    ..Both bilateral pleural effusion with or without ipsilateral pulmonary lesions and ascites ensued, and it was assumed that both direct ..
  23. Porcel J. Tuberculous pleural effusion. Lung. 2009;187:263-70 pubmed publisher
    Tuberculous pleural effusion is one of the most common forms of extrapulmonary tuberculosis (TB). The immediate cause of the effusion is a delayed hypersensitivity response to mycobacterial antigens in the pleural space...
  24. Heffner J, Klein J, Hampson C. Interventional management of pleural infections. Chest. 2009;136:1148-1159 pubmed publisher
    ..The present review provides an update on the pathogenesis and interventional therapy of pleural infections with an emphasis on the unique role of image-guided drainage with small-bore catheters. ..
  25. Sahn S. The value of pleural fluid analysis. Am J Med Sci. 2008;335:7-15 pubmed publisher
    ..With this approach, a definitive or confident clinical diagnosis can be expected in up to 95% of patients. The information in this report should allow the clinician to achieve this goal. ..
  26. Moschos C, Porfiridis I, Psallidas I, Kollintza A, Stathopoulos G, Papiris S, et al. Osteopontin is upregulated in malignant and inflammatory pleural effusions. Respirology. 2009;14:716-22 pubmed publisher
    ..While PF and PF/serum OPN were higher in patients with malignancies, the diagnostic accuracy of the tests was not sufficient to permit routine use in clinical practice. ..
  27. Seiscento M, Vargas F, Acencio M, Teixeira L, Capelozzi V, Sales R, et al. Pleural fluid cytokines correlate with tissue inflammatory expression in tuberculosis. Int J Tuberc Lung Dis. 2010;14:1153-8 pubmed
    ..A tertiary care research centre in São Paolo, Brazil...
  28. Jian G, Songwen Z, Ling Z, Qinfang D, Jie Z, Liang T, et al. Prediction of epidermal growth factor receptor mutations in the plasma/pleural effusion to efficacy of gefitinib treatment in advanced non-small cell lung cancer. J Cancer Res Clin Oncol. 2010;136:1341-7 pubmed publisher
    ..In this study, we attempted to detect EGFR mutations in plasma and pleural effusion samples and to make clear its correlations with gefitinib response and survival in NSCLC patients...
  29. Uto T, Bando M, Yamauchi H, Nakayama M, Ohata M, Mato N, et al. Primary cardiac angiosarcoma of the right auricle with difficult-to-treat bilateral pleural effusion. Intern Med. 2011;50:2371-4 pubmed
    ..The pleural effusion was drained continuously; however, she died of circulatory insufficiency at day 45 from admission...
  30. Grimberg A, Shigueoka D, Atallah A, Ajzen S, Iared W. Diagnostic accuracy of sonography for pleural effusion: systematic review. Sao Paulo Med J. 2010;128:90-5 pubmed
    The initial method for evaluating the presence of pleural effusion was chest radiography...
  31. Rahman N, Singanayagam A, Davies H, Wrightson J, Mishra E, Lee Y, et al. Diagnostic accuracy, safety and utilisation of respiratory physician-delivered thoracic ultrasound. Thorax. 2010;65:449-53 pubmed publisher
    ..pleural procedures are associated with fewer adverse events than 'blind' procedures for patients with pleural effusion. Ultrasound is increasingly practised by respiratory physicians but there has been no prospective assessment ..
  32. Liang S, Tu C, Chen H, Chen C, Chen W, Shih C, et al. Application of ultrasound-guided pigtail catheter for drainage of pleural effusions in the ICU. Intensive Care Med. 2009;35:350-4 pubmed publisher
    ..follows: thoracic empyema (n = 59, 44%), massive transudative pleural effusions (n = 33, 25%), postoperative pleural effusion (n = 29, 15%), malignant pleural effusion (n = 18, 14%) and traumatic hemothorax (n = 3, 2%)...
  33. Baba K, Hoosen A, Langeland N, Dyrhol Riise A. Adenosine deaminase activity is a sensitive marker for the diagnosis of tuberculous pleuritis in patients with very low CD4 counts. PLoS ONE. 2008;3:e2788 pubmed publisher
    Adenosine Deaminase Activity (ADA) is a commonly used marker for the diagnosis of tuberculous pleural effusion. There has been concern about its usefulness in immunocompromised patients, especially HIV positive patients with very low CD4 ..
  34. Chalmers J, Singanayagam A, Murray M, Scally C, Fawzi A, Hill A. Risk factors for complicated parapneumonic effusion and empyema on presentation to hospital with community-acquired pneumonia. Thorax. 2009;64:592-7 pubmed publisher
    ..84 (95% CI 0.81 to 0.86, p < 0.0001). This study has identified seven clinical factors predicting the development of complicated parapneumonic effusion or empyema. Independent validation is needed. ..
  35. Hernandez Bou S, Garcia Garcia J, Esteva C, Gene A, Luaces C, Munoz Almagro C. Pediatric parapneumonic pleural effusion: epidemiology, clinical characteristics, and microbiological diagnosis. Pediatr Pulmonol. 2009;44:1192-200 pubmed publisher
    In recent years an increase in the incidence and severity of parapneumonic pleural effusion (PPE) in pediatric populations has been observed. Streptococcus pneumoniae remains the main causal agent...
  36. Katanyuwong P, Dearani J, Driscoll D. The role of pleurodesis in the management of chylous pleural effusion after surgery for congenital heart disease. Pediatr Cardiol. 2009;30:1112-6 pubmed publisher
    This study aimed to determine the incidence and outcome of postoperative chylous pleural effusion as well as the efficacy of pleurodesis for its management after surgery for congenital heart disease...
  37. Falguera M, Carratala J, Bielsa S, Garcia Vidal C, Ruiz Gonzalez A, Chica I, et al. Predictive factors, microbiology and outcome of patients with parapneumonic effusion. Eur Respir J. 2011;38:1173-9 pubmed publisher
    ..to determine the incidence, clinical consequences and microbiological findings related to the presence of pleural effusion in community-acquired pneumonia, and to identify predictive factors for empyema/complicated parapneumonic ..
  38. Sun Y, Wu G, Fang C, Liu S. Diagnostic utility of MOC-31, HBME-1 and MOC-31 mRNA in distinguishing between carcinoma cells and reactive mesothelial cells in pleural effusions. Acta Cytol. 2009;53:619-24 pubmed
    ..2%, respectively. The detection of MOC-31, HBME-1 and MOC-31-mRNA is helpful in distinguishing between cancer and reactive mesothelial cells in pleural effusions. MOC-31mRNA could be useful to the diagnosis of pleural micrometastasis. ..
  39. Kohmo S, Kijima T, Mori M, Minami T, Namba Y, Yano Y, et al. CXCL12 as a biological marker for the diagnosis of tuberculous pleurisy. Tuberculosis (Edinb). 2012;92:248-52 pubmed publisher
    ..Increased CXCL12 level in pleural fluid could be an informative diagnostic marker for differentiating TB pleurisy from other etiologies...
  40. Yu J, Salamon D, Marcon M, Nahm M. Pneumococcal serotypes causing pneumonia with pleural effusion in pediatric patients. J Clin Microbiol. 2011;49:534-8 pubmed publisher
    To determine the prevalence of serotypes of Streptococcus pneumoniae responsible for pneumonia with pleural effusion, we determined the capsular polysaccharide (PS) type directly on 49 pleural fluid specimens collected from pediatric ..
  41. Masago K, Togashi Y, Fukudo M, Terada T, Irisa K, Sakamori Y, et al. Plasma and pleural fluid pharmacokinetics of erlotinib and its active metabolite OSI-420 in patients with non-small-cell lung cancer with pleural effusion. Clin Lung Cancer. 2011;12:307-12 pubmed publisher
    ..Thus, we investigated the pharmacokinetics (PK) of erlotinib and its active metabolite OSI-420 in non-small-cell lung cancer (NSCLC) of malignant pleural effusion (MPE).
  42. Porcel J. Pleural fluid tests to identify complicated parapneumonic effusions. Curr Opin Pulm Med. 2010;16:357-61 pubmed publisher
    ..In about 30% of these patients, the condition progresses to complicated parapneumonic effusion (CPPE) or to empyema. Pleural fluid analysis may aid decision-making for drainage in nonpurulent pleural fluids...
  43. Light R. Pleural effusions. Med Clin North Am. 2011;95:1055-70 pubmed publisher
    There are many diseases that cause pleural effusions. When a patient with a pleural effusion is first evaluated, one should determine if the patient has a transudate or an exudate...
  44. Abramowitz Y, Simanovsky N, Goldstein M, Hiller N. Pleural effusion: characterization with CT attenuation values and CT appearance. AJR Am J Roentgenol. 2009;192:618-23 pubmed publisher
    ..The purpose of this study was to assess the utility of CT in characterizing pleural effusions on the basis of attenuation values and CT appearance...
  45. Kalantri Y, Hemvani N, Chitnis D. Evaluation of real-time polymerase chain reaction, interferon-gamma, adenosine deaminase, and immunoglobulin A for the efficient diagnosis of pleural tuberculosis. Int J Infect Dis. 2011;15:e226-31 pubmed publisher
    ..Conventional diagnosis methods have limitations. We evaluated the real-time polymerase chain reaction (PCR), interferon-gamma (IFN-?), adenosine deaminase (ADA), and immunoglobulin A (IgA)...
  46. Peris A, Tutino L, Zagli G, Batacchi S, Cianchi G, Spina R, et al. The use of point-of-care bedside lung ultrasound significantly reduces the number of radiographs and computed tomography scans in critically ill patients. Anesth Analg. 2010;111:687-92 pubmed publisher
    ..In this study we assessed the efficacy of routine bedside lung ultrasound (LUS) in the evaluation of pleural effusions (PE) in the ICU...
  47. Wong C, Holroyd Leduc J, Straus S. Does this patient have a pleural effusion?. JAMA. 2009;301:309-17 pubmed publisher
    b>Pleural effusion is a common finding among patients presenting with respiratory symptoms. The value of the bedside examination to detect pleural effusion is unclear.
  48. Haass C, Sorrentino E, Tempera A, Consigli C, De Paola D, Calcagni G, et al. Cardiac tamponade and bilateral pleural effusion in a very low birth weight infant. J Matern Fetal Neonatal Med. 2009;22:137-9 pubmed publisher
    ..Besides tensive pericardial effusion a bilateral pleural effusion also developed...
  49. Karabinis A, Saranteas T, Karakitsos D, Lichtenstein D, Poularas J, Yang C, et al. The 'cardiac-lung mass' artifact: an echocardiographic sign of lung atelectasis and/or pleural effusion. Crit Care. 2008;12:R122 pubmed publisher
    ..We conducted an ultrasound study to investigate echocardiographic artifacts in mechanically ventilated patients with lung pathology...
  50. Doelken P. Management of pleural effusion in the cancer patient. Semin Respir Crit Care Med. 2010;31:734-42 pubmed publisher
    The differential diagnosis of a pleural effusion is expanded in the cancer patient...
  51. Grigoriu B, Chahine B, Zerimech F, Gregoire M, Balduyck M, Copin M, et al. Serum mesothelin has a higher diagnostic utility than hyaluronic acid in malignant mesothelioma. Clin Biochem. 2009;42:1046-50 pubmed publisher
    ..We assessed comparatively the diagnostic value of two potential malignant pleural mesothelioma (MPM) markers: hyaluronic acid (HA) and soluble mesothelin...
  52. Toossi Z, Hirsch C, Wu M, Mayanja Kizza H, Baseke J, Thiel B. Distinct cytokine and regulatory T cell profile at pleural sites of dual HIV/tuberculosis infection compared to that in the systemic circulation. Clin Exp Immunol. 2011;163:333-8 pubmed publisher
    ..A correlation in expansion of T(reg) with proinflammatory cytokines (IL-6 and IL-8) in pleural fluid was shown. T(reg) themselves may promote the inflammatory cytokine milieu through IL-8...
  53. Economidou F, Antoniou K, Tzanakis N, Sfiridaki K, Siafakas N, Schiza S. Angiogenic molecule Tie-2 and VEGF in the pathogenesis of pleural effusions. Respir Med. 2008;102:774-9 pubmed publisher
    The role of angiogenesis in the pathogenesis of pleural effusion (PE) has not been determined. The expression of angiogenic factors may represent useful markers for the diagnosis and prediction of disease outcome...
  54. Economidou F, Antoniou K, Soufla G, Lasithiotaki I, Karagiannis K, Lymbouridou R, et al. Role of VEGF-stromal cell-derived factor-1alpha/CXCL12 axis in pleural effusion of lung cancer. J Recept Signal Transduct Res. 2010;30:154-60 pubmed publisher
    ..We have investigated the role of vascular endothelial growth factor (VEGF), angiopoietins (Ang-1 and Ang-2) and the biological axis of CXCL12-CXCR4, in patients with malignant pleural effusions (PEs)...
  55. Ye Z, Zhou Q, Du R, Li X, Huang B, Shi H. Imbalance of Th17 cells and regulatory T cells in tuberculous pleural effusion. Clin Vaccine Immunol. 2011;18:1608-15 pubmed publisher
    ..cells (Th17 cells) and regulatory T cells (Tregs) have been found to be increased in human tuberculous pleural effusion (TPE); however, the possible interaction between Th17 cells and Tregs in TPE remains to be elucidated...
  56. Wu Y, Lin Y, Hsu C, Chu S, Tsai S. Massive ipsilateral pleural effusion caused by transdiaphragmatic intercostal hernia. Am J Emerg Med. 2008;26:252.e3-4 pubmed publisher
    ..left-sided upper abdominal blunt injury 2 months before admission presented with a newly developed, massive pleural effusion and clinical manifestations of intestinal obstruction...
  57. Teshigawara K, Kakizaki S, Horiya M, Kikuchi Y, Hashida T, Tomizawa Y, et al. Primary Sjogren's syndrome complicated by bilateral pleural effusion. Respirology. 2008;13:155-8 pubmed publisher
    ..There was no evidence of infection, malignancy or other collagen diseases which cause pleuritis. We conclude that this case adds to the eight previously published reports of primary Sjogren's syndrome complicated by pleural effusion.
  58. Yamada S, Tabata C, Tabata R, Fukuoka K, Nakano T. Clinical significance of pleural effusion mesothelin in malignant pleural mesothelioma. Clin Chem Lab Med. 2011;49:1721-6 pubmed publisher
    ..This study investigated the pleural effusion mesothelin levels in patients with MPM and compared them to those of a population with a non-malignant ..
  59. Botana Rial M, Casado Rey P, Leiro Fernández V, Andrade Olivié M, Represas Represas C, Fernandez Villar A. Validity of procalcitonin and C-reactive protein measurement when differentiating between benign and malignant pleural effusion. Clin Lab. 2011;57:373-8 pubmed
    ..CRP) measurements in pleural fluid and plasma have been proposed to facilitate differential diagnosis of pleural effusion (PE)...
  60. Ono S, Iwai N, Chiba F, Furukawa T, Fumino S. OK-432 therapy for chylous pleural effusion or ascites associated with lymphatic malformations. J Pediatr Surg. 2010;45:e7-10 pubmed publisher
    ..injection of OK-432 for 2 patients with diffuse microcystic LMs accompanied by refractory chylous pleural effusion or chylous ascites...
  61. Rodríguez Piñeiro A, Blanco Prieto S, Sánchez Otero N, Rodriguez Berrocal F, de la Cadena M. On the identification of biomarkers for non-small cell lung cancer in serum and pleural effusion. J Proteomics. 2010;73:1511-22 pubmed publisher
    ..for new biomarkers of non-small cell lung cancer (NSCLC) prompted us to compare the proteome of serum and pleural effusion samples from cancer patients with those with benign lung diseases as pneumonia or tuberculosis...
  62. Ciledag A, Kaya A, Erol S, Sen E, Celik G, Cesur S, et al. The comparison of pleural fluid TNF-alpha and IL-10 levels with ADA in tuberculous pleural effusion. Curr Med Chem. 2010;17:2096-100 pubmed
    Our aim was to evaluate the diagnostic value of pleural fluid TNF-alpha and IL-10 levels in tuberculous pleural effusion (TPE) and compare with that of ADA.
  63. Hampson C, Lemos J, Klein J. Diagnosis and management of parapneumonic effusions. Semin Respir Crit Care Med. 2008;29:414-26 pubmed publisher
    ..We propose an algorithmic approach to patients with parapneumonic effusions and advocate image-guided drainage and management in patients likely to benefit from this treatment...
  64. Kwon J, Cha S, Jeon K, Kim Y, Kim E, Kim C, et al. Factors influencing residual pleural opacity in tuberculous pleural effusion. J Korean Med Sci. 2008;23:616-20 pubmed publisher
    Tuberculous pleural effusion (TPE) leads to residual pleural opacity (RPO) in a significant proportion of cases. The aim of this study was to investigate which TPE patients would have RPO following the treatment...
  65. Pefura Yone E, Kuaban C, Simo L. [Tuberculous pleural effusion in Yaounde, Cameroon: The influence of HIV infection]. Rev Mal Respir. 2011;28:1138-45 pubmed publisher
    The objective of this study was to investigate the current impact of HIV infection on the clinical presentation, laboratory features and outcome of tuberculous pleural effusion in adult patients in Yaounde.
  66. Masson A, Menetrey C, Garnier F, Bahans C, Fargeot A, Layadi M, et al. [Parapneumonic pleural effusion incidence in a French region before and during the antipneumococcal vaccine era]. Arch Pediatr. 2011;18:846-9 pubmed publisher
    The aim of the study was to compare the incidence of parapneumonic pleural effusion in the Limousin region of France, based on the comparison of pre- and postvaccination periods.
  67. Nasser H, Kuntzman T. Pleural effusion in women with a known adenocarcinoma: the role of immunostains in uncovering another hidden primary tumor. Acta Cytol. 2011;55:438-44 pubmed publisher
    ..We aim to identify the percentage of adenocarcinomas metastatic to pleural effusion in women and the frequency of another primary tumor being the origin of the effusion using morphology and ..
  68. Tarrago D, Fenoll A, Sanchez Tatay D, Arroyo L, Munoz Almagro C, Esteva C, et al. Identification of pneumococcal serotypes from culture-negative clinical specimens by novel real-time PCR. Clin Microbiol Infect. 2008;14:828-34 pubmed publisher
    ..Such molecular methods are critical for the diagnosis of invasive pneumococcal disease and continued epidemiological surveillance in order to monitor serotype vaccine effectiveness...
  69. Oikonomidi S, Kostikas K, Tsilioni I, Tanou K, Gourgoulianis K, Kiropoulos T. Matrix metalloproteinases in respiratory diseases: from pathogenesis to potential clinical implications. Curr Med Chem. 2009;16:1214-28 pubmed
  70. Porkka K, Khoury H, Paquette R, Matloub Y, Sinha R, Cortes J. Dasatinib 100 mg once daily minimizes the occurrence of pleural effusion in patients with chronic myeloid leukemia in chronic phase and efficacy is unaffected in patients who develop pleural effusion. Cancer. 2010;116:377-86 pubmed publisher
    ..In a phase 3 dose optimization trial in patients with CML CP (CA180-034), the occurrence of pleural effusion was significantly minimized with dasatinib 100 mg once daily (QD) compared with other treatment arms (70 mg ..
  71. Mironov O, Ishill N, Mironov S, Vargas H, Zheng J, Moskowitz C, et al. Pleural effusion detected at CT prior to primary cytoreduction for stage III or IV ovarian carcinoma: effect on survival. Radiology. 2011;258:776-84 pubmed publisher
    ..To determine the prognostic importance of pleural effusions on preoperative computed tomographic (CT) images in patients with advanced epithelial ovarian cancer...
  72. Duysinx B, Corhay J, Hubin L, Nguyen D, Henket M, Louis R. Diagnostic value of interleukine-6, transforming growth factor-beta 1 and vascular endothelial growth factor in malignant pleural effusions. Respir Med. 2008;102:1708-14 pubmed publisher
    ..We evaluate the accuracy of pleural interleukine-6 (IL-6), transforming growth factor-beta 1 (TGF-beta1), and vascular endothelial growth factor (VEGF) levels for differentiating benign from malignant pleural exudates...
  73. Papaioannou A, Kostikas K, Tsopa P, Kiropoulos T, Tsilioni I, Oikonomidi S, et al. Residual pleural thickening is related to vascular endothelial growth factor levels in parapneumonic pleural effusions. Respiration. 2010;80:472-9 pubmed publisher
    ..Pleural fluid vascular endothelial growth factor (VEGF) levels are known to be elevated in complicated parapneumonic effusion and seem to play a major role in the fibrotic process in the pleura...
  74. Ødegaard E, Davidson B, Engh V, Onsrud M, Staff A. Assessment of endoglin and calprotectin as potential biomarkers in ovarian carcinoma and borderline tumors of the ovary. Am J Obstet Gynecol. 2008;199:533.e1-8 pubmed publisher
    ..The objective of the study was to analyze circulating endoglin concentration in ovarian carcinoma and evaluate a prognostic role for calprotectin and endoglin in effusions in advanced-stage disease...
  75. Koegelenberg C, Diacon A, Bolliger C. Parapneumonic pleural effusion and empyema. Respiration. 2008;75:241-50 pubmed publisher
    At least 40% of all patients with pneumonia will have an associated pleural effusion, although a minority will require an intervention for a complicated parapneumonic effusion or empyema...
  76. Li H, Hua F, Zhao C, Liu G, Zhou Q. [Diagnotic value of the combined determination of telomerase activity in induced sputum, pleural effusion and fiberobronchoscopic biopsy samples in lung cancer]. Zhongguo Fei Ai Za Zhi. 2010;13:128-31 pubmed publisher
    ..The aim of this study is to investigate the diagnostic value of the combined determination of telomerase activity in induced sputum, pleural effusion and fiberobronchoscopic biopsy in lung cancer patients.
  77. Marchi E, Vargas F, Acencio M, Sigrist R, Biscaro M, Antonangelo L, et al. Proinflammatory and antiinflammatory cytokine levels in complicated and noncomplicated parapneumonic pleural effusions. Chest. 2012;141:183-189 pubmed publisher
    ..This study aimed to evaluate a panel of proinflammatory and antiinflammatory cytokines in noncomplicated and complicated parapneumonic pleural effusions and to correlate their levels with pleural fluid biochemical parameters...
  78. Dheda K, van Zyl Smit R, Sechi L, Badri M, Meldau R, Symons G, et al. Clinical diagnostic utility of IP-10 and LAM antigen levels for the diagnosis of tuberculous pleural effusions in a high burden setting. PLoS ONE. 2009;4:e4689 pubmed publisher
    ..Detection of LAM antigen has not previously been evaluated in pleural fluid...
  79. Rahman N, Maskell N, West A, Teoh R, Arnold A, Mackinlay C, et al. Intrapleural use of tissue plasminogen activator and DNase in pleural infection. N Engl J Med. 2011;365:518-26 pubmed publisher
    ..Drainage of infected fluid is key to successful treatment, but intrapleural fibrinolytic therapy did not improve outcomes in an earlier, large, randomized trial...
  80. Liang Q, Shi H, Wang K, Qin S, Qin X. Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: a meta-analysis. Respir Med. 2008;102:744-54 pubmed publisher
    ..We conducted a meta-analysis to determine the accuracy of ADA measurements in the diagnosis of tuberculous pleurisy...
  81. Schneider T, Reimer P, Storz K, Klopp M, Pfannschmidt J, Dienemann H, et al. Recurrent pleural effusion: who benefits from a tunneled pleural catheter?. Thorac Cardiovasc Surg. 2009;57:42-6 pubmed publisher
    Recurrent malignant pleural effusion (MPE) is a common concomitant phenomenon of malignant disease, which can worsen the patient's quality of life and lead to significant morbidity...
  82. Supriya P, Chandrasekaran P, Das S. Diagnostic utility of interferon-gamma-induced protein of 10 kDa (IP-10) in tuberculous pleurisy. Diagn Microbiol Infect Dis. 2008;62:186-92 pubmed publisher
    ..930). The better sensitivity (84.2% for IFN-gamma and 89.2% for IP-10) and equal specificity (95.7%) of IP-10 assay compared with IFN-gamma suggest that IP-10 is a potential diagnostic marker for evaluating TP...