chylothorax

Summary

Summary: The presence of chyle in the thoracic cavity. (Dorland, 27th ed)

Top Publications

  1. Akin H, Olcmen A, Isgorucu O, Denizkiran I, Dincer I. Approach to patients with chylothorax complicating pulmonary resection. Thorac Cardiovasc Surg. 2012;60:135-9 pubmed publisher
    ..node dissection, an important part of surgery for non-small cell lung cancer, is associated with a risk of chylothorax. Although mortality has significantly decreased in recent years, it still worries thoracic surgeons...
  2. Nygaard U, Sundberg K, Nielsen H, Hertel S, Jørgensen C. New treatment of early fetal chylothorax. Obstet Gynecol. 2007;109:1088-92 pubmed
    To evaluate OK-432, a preparation of Streptococcus pyogenes, in the treatment of early fetal chylothorax. A prospective study of all fetuses (n=7) with persistent early chylothorax (gestational ages 16-21 weeks) referred to the tertiary ..
  3. Chen C, Chen T, Kuo S, Chen C, Lee D, Ke Y, et al. Genetic evaluation and management of fetal chylothorax: review and insights from a case of Noonan syndrome. Lymphology. 2009;42:134-8 pubmed
    Fetal chylothorax is one of a very few syndromes that can be treated in utero with thoracoamniotic shunting or pleurodesis by OK-432 as two major therapeutic modalities. We report on a fetus with Noonan syndrome and a missense mutation c...
  4. Talwar A, Lee H. A contemporary review of chylothorax. Indian J Chest Dis Allied Sci. 2008;50:343-51 pubmed
    This review will focus on anatomical and aetiologic factors as well as the conservative and operative therapy of chylothorax. A Pubmed search for studies pertaining to the aetiology and/or treatment published in the English language from ..
  5. Cleveland K, Zook D, Harvey K, Woods R. Massive chylothorax in small babies. J Pediatr Surg. 2009;44:546-50 pubmed publisher
    Perceptions on the role and timing of surgical intervention for high-output or massive chylothorax in small and premature babies remain varied...
  6. Chen M, Hsieh C, Shih J, Chou C, Ma G, Chen T, et al. Proinflammatory macrophage migratory inhibition factor and interleukin-6 are concentrated in pleural effusion of human fetuses with prenatal chylothorax. Prenat Diagn. 2007;27:435-41 pubmed
    ..To study the role of selected cytokines and growth factors involved in the pathogenesis of fetal chylous pleural effusion...
  7. Ma G, Liu C, Chang S, Yeh K, Ke Y, Chen T, et al. A recurrent ITGA9 missense mutation in human fetuses with severe chylothorax: possible correlation with poor response to fetal therapy. Prenat Diagn. 2008;28:1057-63 pubmed publisher
    To assess the possible correlations between the reported candidate genes (VEGFR3, FOXC2, ITGA9 and ITGB1) and the clinical response in fetuses with severe congenital chylothorax (CC) treated by prenatal OK-432 pleurodesis.
  8. McCulloch M, Conaway M, Haizlip J, Buck M, Bovbjerg V, Hoke T. Postoperative chylothorax development is associated with increased incidence and risk profile for central venous thromboses. Pediatr Cardiol. 2008;29:556-61 pubmed
    This study tested the hypothesis that pediatric patients who develop chylothorax (CTX) after surgery for congenital heart disease (CHD) have an elevated incidence and risk profile for central venous thrombosis (CVT)...
  9. Huggins J. Chylothorax and cholesterol pleural effusion. Semin Respir Crit Care Med. 2010;31:743-50 pubmed publisher
    A chylothorax and a cholesterol pleural effusion represent the two forms of lipid effusions encountered. Traditionally, a lipid pleural effusion is characterized by the presence of milky fluid...

More Information

Publications66

  1. Cho H, Kim D, Lee G, Sim H, Choi S, Kim H, et al. Chylothorax complicating pulmonary resection for lung cancer: effective management and pleurodesis. Ann Thorac Surg. 2014;97:408-13 pubmed publisher
    b>Chylothorax associated with pulmonary resection for lung cancer, although rare, must be considered as a potential complication during thoracic surgery...
  2. Cowie R, Stone P, Parry E, Jensen E, Gunn A, Bennet L. Acute behavioral effects of intrapleural OK-432 (Picibanil) administration in preterm fetal sheep. Fetal Diagn Ther. 2009;25:304-13 pubmed publisher
    ..To develop a model to study the fetal effects of intrapleural infusion of OK-432 (Picibanil), a pleurodesis agent derived from killed Gram-positive streptococci...
  3. Cigarral C, Montero A, Salas C, Rodríguez G, De la Torre A. Chylothorax due to metastatic prostate carcinoma: an unusual complication. Clin Transl Oncol. 2009;11:767-9 pubmed
    b>Chylothorax, the abnormal accumulation of lymphatic fluid within the pleural space, is an infrequent complication of tumours affecting the mediastinum...
  4. Maldonado F, Cartin Ceba R, Hawkins F, Ryu J. Medical and surgical management of chylothorax and associated outcomes. Am J Med Sci. 2010;339:314-8 pubmed publisher
    b>Chylothorax is an uncommon form of pleural effusion that can be associated with traumatic and nontraumatic causes. Optimal management and outcome for patients with chylothorax remain unclear...
  5. Zabeck H, Muley T, Dienemann H, Hoffmann H. Management of chylothorax in adults: when is surgery indicated?. Thorac Cardiovasc Surg. 2011;59:243-6 pubmed publisher
    The aim of this retrospective study was to analyze the etiology, management and outcome of patients with chylothorax and identify clinical parameters for appropriate treatment decisions.
  6. Chalret Du Rieu M, Baulieux J, Rode A, Mabrut J. Management of postoperative chylothorax. J Visc Surg. 2011;148:e346-52 pubmed publisher
    b>Chylothorax is a rare but severe complication of thoracic and esophageal surgery...
  7. Boffa D, Sands M, Rice T, Murthy S, Mason D, Geisinger M, et al. A critical evaluation of a percutaneous diagnostic and treatment strategy for chylothorax after thoracic surgery. Eur J Cardiothorac Surg. 2008;33:435-9 pubmed publisher
    Because chylothorax complicating thoracic surgery is difficult to diagnose and failure of nonoperative management necessitates further surgery, we critically evaluated an evolving percutaneous strategy for diagnosing and treating ..
  8. Agrawal V, Doelken P, Sahn S. Seat belt-induced chylothorax: a cause of idiopathic chylothorax?. Chest. 2007;132:690-2 pubmed
    ..Idiopathic chylothoraces may account for up to 15% of all chylothoraces. When a thorough evaluation finding is negative, further history to identify possible blunt, nonpenetrating trauma to the chest is warranted...
  9. Kushwaha R, Verma S, Sanjay -, Mahajan V, Prasad R. Bilateral chylothorax in a child after mild trauma. Indian J Chest Dis Allied Sci. 2008;50:355-7 pubmed
    b>Chylothorax is a life-threatening form of pleural effusion with a varied aetiology. In this report, we describe the case of a child who developed bilateral chylothorax following minor trauma which responded well to conservative management.
  10. Panthongviriyakul C, Bines J. Post-operative chylothorax in children: an evidence-based management algorithm. J Paediatr Child Health. 2008;44:716-21 pubmed publisher
    To develop an evidence-based algorithm for the therapeutic approach to the management of post-operative chylothorax.
  11. Maldonado F, Hawkins F, Daniels C, Doerr C, Decker P, Ryu J. Pleural fluid characteristics of chylothorax. Mayo Clin Proc. 2009;84:129-33 pubmed publisher
    To determine the biochemical parameters of chylous pleural fluids and better inform current clinical practice in the diagnosis of chylothorax.
  12. Matsukuma E, Aoki Y, Sakai M, Kawamoto N, Watanabe H, Iwagaki S, et al. Treatment with OK-432 for persistent congenital chylothorax in newborn infants resistant to octreotide. J Pediatr Surg. 2009;44:e37-9 pubmed publisher
    b>Chylothorax is a relatively uncommon condition defined as an abnormal collection of lymphatic fluid within the pleural space...
  13. Rabie H, Lomp A, Goussard P, Nel E, Cotton M. Paradoxical tuberculosis associated immune reconstitution inflammatory syndrome presenting with chylous ascites and chylothorax in a HIV-1 infected child. J Trop Pediatr. 2010;56:355-8 pubmed publisher
    ..TB) paradoxical immune reconstitution inflammatory syndrome (IRIS) complicated by chylous ascites and chylothorax in a HIV-infected child. There are few descriptions of TB IRIS in children...
  14. Litherland B, Given M, Lyon S. Percutaneous radiological management of high-output chylothorax with CT-guided needle disruption. J Med Imaging Radiat Oncol. 2008;52:164-7 pubmed publisher
    We present the study of a 58-year-old man who underwent percutaneous management of a high-output chylothorax following cardiac bypass graft surgery...
  15. Tian W, Li Z, Wang P, Lin X. Chylothorax after neck dissection for thyroid carcinomas: report of three cases. Surg Today. 2012;42:89-92 pubmed publisher
    b>Chylothorax is a rare complication of neck dissection. We report three cases of chylothorax after neck dissections for thyroid carcinoma and attribute this relatively high incidence to the assumption that most patients are asymptomatic...
  16. McGrath E, Blades Z, Anderson P. Chylothorax: aetiology, diagnosis and therapeutic options. Respir Med. 2010;104:1-8 pubmed publisher
    b>Chylothorax is a rare condition that results from thoracic duct damage with chyle leakage from the lymphatic system into the pleural space, usually on the right side...
  17. Chachaj A, Drozdz K, Chabowski M, Dziegiel P, Grzegorek I, Wojnar A, et al. Chyloperitoneum, chylothorax and lower extremity lymphedema in woman with sporadic lymphangioleiomyomatosis successfully treated with sirolimus: a case report. Lymphology. 2012;45:53-7 pubmed
    ..The most typical presenting symptoms include dyspnea, spontaneous pneumothorax, cough and chylothorax. Abdominal findings represent less common initial manifestations of the disease and may pose diagnostic ..
  18. Carobbi B, White R, Romanelli G. Treatment of idiopathic chylothorax in 14 dogs by ligation of the thoracic duct and partial pericardiectomy. Vet Rec. 2008;163:743-5 pubmed
    ..associated with thoracic duct ligation combined with partial pericardiectomy in 14 dogs with idiopathic chylothorax were investigated retrospectively. Nine of the dogs were treated in the uk and five in Italy...
  19. Schoellnast H, Maybody M, Getrajdman G, Bains M, Finley D, Solomon S. Computed tomography-guided access to the cisterna chyli: introduction of a technique for direct lymphangiography to evaluate and treat chylothorax. Cardiovasc Intervent Radiol. 2011;34 Suppl 2:S240-4 pubmed publisher
    The purpose of this report is to introduce a technique of direct lymphangiography to enable chylothorax treatment...
  20. Helin R, Angeles S, Bhat R. Octreotide therapy for chylothorax in infants and children: A brief review. Pediatr Crit Care Med. 2006;7:576-9 pubmed
    We review physiology and pharmacology relating to the use of octreotide for chylothorax in infants and children. We review the published experience of octreotide dosing in this context.
  21. Khurana H, Mishra S, Jain R, Goyal G, Bhatnagar S. Management of postoperative chylothorax in a patient with carcinoma of thyroid and lymphadenopathy--a case report. Middle East J Anaesthesiol. 2009;20:121-3 pubmed
    b>Chylothorax is a rare but serious complication following neck dissection with an incidence of 0.5%-2%...
  22. Vavilis D, Papadopoulos N, Agorastos T, Efstratiou I, Kommoss F, Bontis I. Primary ovarian angiosarcoma--review of the literature and report of a case with coexisting chylothorax. Eur J Gynaecol Oncol. 2007;28:287-9 pubmed
    ..Its exact diagnosis is challenging for surgeons and difficult for pathologists. There are only a few cases reported in the international literature...
  23. Cakir E, Gocmen B, Uyan Z, Oktem S, Kiyan G, Karakoc F, et al. An unusual case of chylothorax complicating childhood tuberculosis. Pediatr Pulmonol. 2008;43:611-4 pubmed publisher
    Endobronchial tuberculosis (EBTB) and chylothorax are rare clinical disorders. The concurrence of these two disorders as manifestations of childhood pulmonary tuberculosis has not been reported...
  24. Barili F, Polvani G, Topkara V, Dainese L, Roberto M, Aljaber E, et al. Administration of octreotide for management of postoperative high-flow chylothorax. Ann Vasc Surg. 2007;21:90-2 pubmed
    b>Chylothorax is a rare complication of adult cardiothoracic surgery that can affect the postoperative course as it can lead to respiratory insufficiency, protein loss, fluid imbalance, and immunodeficiency...
  25. Chen J, Li W, Hsu C, Tsai H, Tsai W, Tsai L, et al. Chylous ascites and chylothorax: an unusual manifestation of cardiac amyloidosis. Intern Med. 2010;49:1763-6 pubmed
    Restrictive cardiomyopathy is an extremely rare cause of massive chylous ascites and chylothorax. We report a 56-year-old man patient who presented with chylous ascites and bilateral chylothorax; 12-lead electrocardiography and ..
  26. Yang Y, Ma G, Shih J, Chen C, Chou C, Yeh K, et al. Experimental treatment of bilateral fetal chylothorax using in-utero pleurodesis. Ultrasound Obstet Gynecol. 2012;39:56-62 pubmed publisher
    To assess the use and efficacy of in-utero pleurodesis for experimental treatment of bilateral fetal chylothorax.
  27. Inayama M, Shinohara T, Hino H, Yoshida M, Ogushi F. Chylothorax caused by acupuncture. Intern Med. 2011;50:2375-7 pubmed
    b>Chylothorax, the accumulation of fatty fluid within the chest cavity, is associated with multiple etiologies including surgical injuries...
  28. Miura K, Ono H, Endou H, Nagata T, Kougo M, Oono M, et al. [Treatment of a persistent postoperative chylothorax with octreotide]. Kyobu Geka. 2009;62:885-7 pubmed
    b>Chylothorax is a serious postoperative complication in the field of thoracic surgery. To treat refractory chylothorax, various methods including surgery are employed...
  29. Ergaz Z, Bar Oz B, Yatsiv I, Arad I. Congenital chylothorax: clinical course and prognostic significance. Pediatr Pulmonol. 2009;44:806-11 pubmed publisher
    To determine the underlying etiology, associated malformations, clinical course, and prognostic significance of congenital chylothorax.
  30. Gerstein J, Kofahl Krause D, Frühauf J, Bremer M. Complete remission of a lymphoma-associated chylothorax by radiotherapy of the celiac trunk and thoracic duct. Strahlenther Onkol. 2008;184:484-7 pubmed publisher
    A chylothorax is a rare complication of mostly advanced malignant lymphomas. A case of a refractory chylothorax unresponsive to chemotherapy and successfully treated with radiotherapy is reported.
  31. Prabhu V, Passant C. Left-sided neck dissection and chylothorax: a rare complication and its management. J Laryngol Otol. 2012;126:648-50 pubmed publisher
    We present a case of bilateral chylothorax, a rare but life-threatening complication, which developed following a left-sided neck dissection.
  32. Han C, Guo L, Wang K, Zhao J. Bilateral chylothorax following neck dissection for thyroid cancer. Int J Oral Maxillofac Surg. 2009;38:1119-22 pubmed publisher
    Bilateral chylothorax is mainly encountered following certain thoracic procedures. It is a rare complication following neck dissection, but can be serious and life threatening...
  33. Schumacher G, Weidemann H, Langrehr J, Jonas S, Mittler J, Jacob D, et al. Transabdominal ligation of the thoracic duct as treatment of choice for postoperative chylothorax after esophagectomy. Dis Esophagus. 2007;20:19-23 pubmed
    Postoperative chylothorax after injury of the thoracic duct during esophagectomy is a rare but severe complication which may lead to serious problems such as loss of fat and proteins, and immunodeficiency...
  34. Jianjun Q, Song Z, Yin L, Jia Z, Donglei L. Treatment of chylothorax with elemene. Thorac Cardiovasc Surg. 2008;56:103-5 pubmed publisher
    b>Chylothorax is a disorder with a variety of causes and is often difficult and complex to manage. There are two treatment options for chylothorax: conservative management or surgical intervention...
  35. Smets K. X-linked myotubular myopathy and chylothorax. Neuromuscul Disord. 2008;18:183-4 pubmed
    ..In the second week of life, he developed a clinically relevant chylothorax, needing drainage and treatment with octreotide acetate...
  36. Stewart K, Padgett S. Chylothorax treated via thoracic duct ligation and omentalization. J Am Anim Hosp Assoc. 2010;46:312-7 pubmed
    b>Chylothorax is an uncommon, potentially life-threatening disease of dogs and cats. Medical records of 12 animals (five dogs and seven cats) undergoing surgical management of chylothorax from 2001 to 2005 were reviewed...
  37. Nair S, Petko M, Hayward M. Aetiology and management of chylothorax in adults. Eur J Cardiothorac Surg. 2007;32:362-9 pubmed
    Though rare in incidence, chylothorax can lead to significant morbidity and mortality. Its occurrence corresponds to increased mortality following esophagectomy...
  38. Kuan Y, How S, Ng T, Abdul Rani M. Intrapleural streptokinase for the treatment of chylothorax. Respir Care. 2011;56:1953-5 pubmed publisher
    b>Chylothorax is suspected when milky white turbid fluid is obtained from thoracocentesis. Conservative management usually involves intercostal tube drainage, dietary restriction, and total parenteral nutrition...
  39. Kawasaki R, Sugimoto K, Fujii M, Miyamoto N, Okada T, Yamaguchi M, et al. Therapeutic effectiveness of diagnostic lymphangiography for refractory postoperative chylothorax and chylous ascites: correlation with radiologic findings and preceding medical treatment. AJR Am J Roentgenol. 2013;201:659-66 pubmed publisher
    The purpose of this study was to assess the therapeutic effect of lymphangiography for refractory postoperative chylothorax and chylous ascites and analyze the relation between the clinical outcomes and radiologic findings or response to ..
  40. Ono S, Iwai N, Chiba F, Furukawa T, Fumino S. OK-432 therapy for chylous pleural effusion or ascites associated with lymphatic malformations. J Pediatr Surg. 2010;45:e7-10 pubmed publisher
    ..We recommend the use of OK-432 therapy as a promising treatment for microcystic LMs with functionally significant lymphatic fluid collections...
  41. Skouras V, Kalomenidis I. Chylothorax: diagnostic approach. Curr Opin Pulm Med. 2010;16:387-93 pubmed publisher
    This review evaluates recent research findings and proposes an up-to-date diagnostic approach for patients with suspected chylothorax.
  42. Thompson K, Kernstine K, Grannis F, Mojica P, Falabella A. Treatment of chylothorax by robotic thoracic duct ligation. Ann Thorac Surg. 2008;85:334-6 pubmed
    This is the first report describing the use of robotic technology for the treatment of chylothorax. We present a 22-year-old with mixed embryonal cell and seminoma germ cell cancer refractory to medical and surgical treatment...
  43. Allman D, Radlinsky M, Ralph A, Rawlings C. Thoracoscopic thoracic duct ligation and thoracoscopic pericardectomy for treatment of chylothorax in dogs. Vet Surg. 2010;39:21-7 pubmed publisher
    To report the use of thoracoscopic thoracic duct ligation (TDL) and pericardectomy for treatment of chylothorax.
  44. Momose M, Kawakami S, Koizumi T, Yoshida K, Kanda S, Kondo R, et al. Lymphoscintigraphy using technetium-99m HSA-DTPA with SPECT/CT in chylothorax after childbirth. Radiat Med. 2008;26:508-11 pubmed publisher
    ..computed tomography combined with integrated low-dose computed tomography (SPECT/CT) is useful for evaluating chylothorax. We report a case of chylothorax that occurred 2 months after childbirth in a 24-year-old woman...
  45. Shigemura N, Kawamura T, Minami M, Sawabata N, Inoue M, Utsumi T, et al. Successful factor XIII administration for persistent chylothorax after lung transplantation for lymphangioleiomyomatosis. Ann Thorac Surg. 2009;88:1003-6 pubmed publisher
    ..However, persisting chylothorax after transplantation for LAM remains a challenging problem, and the optimal management has not been decided...
  46. Paul S, Altorki N, Port J, Stiles B, Lee P. Surgical management of chylothorax. Thorac Cardiovasc Surg. 2009;57:226-8 pubmed publisher
    b>Chylothorax remains an uncommon but challenging clinical problem. Thoracic duct ligation is the treatment of choice for postsurgical patients. However, the optimal treatment for traumatic patients is unclear...
  47. Nath D, Savla J, Khemani R, Nussbaum D, Greene C, Wells W. Thoracic duct ligation for persistent chylothorax after pediatric cardiothoracic surgery. Ann Thorac Surg. 2009;88:246-51; discussion 251-2 pubmed publisher
    There is considerable literature on incidence and medical management of postsurgical chylothorax in children but little is known about outcomes of thoracic duct ligation (TDL) for patients refractory to medical therapy.
  48. Ohara T, Oto T, Miyoshi K, Tao H, Yamane M, Toyooka S, et al. Sirolimus ameliorated post lung transplant chylothorax in lymphangioleiomyomatosis. Ann Thorac Surg. 2008;86:e7-8 pubmed publisher
    ..However, sirolimus treatment reduced the amount of chylous drainage and improved both chylous pleural and peritoneal effusions...
  49. Caserio S, Gallego C, Martin P, Moral M, Pallás C, Galindo A. Congenital chylothorax: from foetal life to adolescence. Acta Paediatr. 2010;99:1571-7 pubmed publisher
    To analyse the main prenatal and postnatal features of congenital chylothorax (CC), and the outcome including mid-term follow-up.
  50. Apostolakis E, Akinosoglou K, Koletsis E, Dougenis D. Traumatic chylothorax following blunt thoracic trauma: two conservatively treated cases. J Card Surg. 2009;24:220-2 pubmed publisher
    b>Chylothorax is rare following blunt thoracic trauma; its diagnosis is usually delayed until the puncture or drainage of posttraumatic pleural effusion and its cause is not clear...
  51. Grobbelaar M, Andronikou S, Goussard P, Theron S, Mapukata A, George R. Chylothorax as a complication of pulmonary tuberculosis in children. Pediatr Radiol. 2008;38:224-6 pubmed
    b>Chylothorax is a rare clinical entity characterized by a milky white aspirate with increased triglyceride levels. The commonest aetiology is malignancy and trauma. Pulmonary tuberculosis is an extremely rare cause of chylothorax...
  52. Kanady J, Dellinger M, Munger S, Witte M, Simon A. Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax. Dev Biol. 2011;354:253-66 pubmed publisher
    ..alone or in combination result in defective valve formation in lymphatic collecting vessels, lymphedema, and chylothorax. We also show that Cx37 regulates jugular lymph sac size and that both Cx37 and Cx43 are required for normal ..
  53. Epaud R, Dubern B, Larroquet M, Tamalet A, Guillemot N, Maurage C, et al. Therapeutic strategies for idiopathic chylothorax. J Pediatr Surg. 2008;43:461-5 pubmed publisher
    The objectives of the study were to present our institutional experience of idiopathic chylothorax in children and to propose therapeutic strategies.
  54. Limsukon A, Yick D, Kamangar N. Chylothorax: a rare complication of tube thoracostomy. J Emerg Med. 2011;40:280-2 pubmed publisher
    b>Chylothorax resulting from chest tube injury to the thoracic duct is very rare and underreported.
  55. Guo W, Zhao Y, Jiang Y, Niu H, Liu X, Ma Z, et al. Prevention of postoperative chylothorax with thoracic duct ligation during video-assisted thoracoscopic esophagectomy for cancer. Surg Endosc. 2012;26:1332-6 pubmed publisher
    ..b>Chylothorax remains a challenging and potentially life-threatening postoperative complication of MIE...
  56. Kose M, Pekcan S, Dogru D, Akyuz C, Ozcelik U, Ozsurekci Y, et al. Gorham-Stout Syndrome with chylothorax: successful remission by interferon alpha-2b. Pediatr Pulmonol. 2009;44:613-5 pubmed publisher
    Gorham-Stout syndrome is a rare disease and most often recognized in children and young adults. Chylothorax is a serious complication of Gorham-Stout syndrome...
  57. Talwar S, Choudhary S, Airan B. Diaphragmatic fenestration for resistant chylothorax. Ann Thorac Surg. 2006;82:767-8 pubmed